KR860003248A - 피록시캄 염의 제조방법 - Google Patents

피록시캄 염의 제조방법

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Publication number
KR860003248A
KR860003248A KR1019850007443A KR850007443A KR860003248A KR 860003248 A KR860003248 A KR 860003248A KR 1019850007443 A KR1019850007443 A KR 1019850007443A KR 850007443 A KR850007443 A KR 850007443A KR 860003248 A KR860003248 A KR 860003248A
Authority
KR
South Korea
Prior art keywords
salt
molar ratio
inert solvent
contacting
producing
Prior art date
Application number
KR1019850007443A
Other languages
English (en)
Other versions
KR870000277B1 (ko
Inventor
죠지 롬바르디노 조세프
Original Assignee
윌리암 데이비스 헌
화이자 인코포레이티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 윌리암 데이비스 헌, 화이자 인코포레이티드 filed Critical 윌리암 데이비스 헌
Publication of KR860003248A publication Critical patent/KR860003248A/ko
Application granted granted Critical
Publication of KR870000277B1 publication Critical patent/KR870000277B1/ko

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/65—One oxygen atom attached in position 3 or 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/65—One oxygen atom attached in position 3 or 5
    • C07D213/66—One oxygen atom attached in position 3 or 5 having in position 3 an oxygen atom and in each of the positions 4 and 5 a carbon atom bound to an oxygen, sulphur, or nitrogen atom, e.g. pyridoxal
    • C07D213/67—2-Methyl-3-hydroxy-4,5-bis(hydroxy-methyl)pyridine, i.e. pyridoxine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • C07D313/02—Seven-membered rings
    • C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C07D313/10—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C07D313/12—[b,e]-condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrane Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

내용 없음

Description

피록시캄염의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (6)

  1. 독세핀과 피록시캄을 반응불활성 용매 중에서 1 : 1 몰비율로 접촉시킴을 특징으르 하는 피록시캄의 독세핀과의 1 : 1염의 제조방법.
  2. 피리독신과 피록시캄을 반응 불활성 용매중에서 1 : 1 몰비율로 접촉시킴을 특징으로 하는 피록시캄의 피리독신과의 1 : 1염의 제조방법.
  3. 2-구아니디노-4-(2-메틸-4-아미다졸릴)-티아졸과 피록시캄을 반응불활성 용매중에서 1 : 1몰비율로 접촉시킴을 특징으로하는 피록시캄의 2-구아니디노-4-(2-메틸-4-아미다졸릴)-티아졸과의 1 : 1염의 제조방법.
  4. 피르부테롤과 피록시캄을 반응불활성 용매중에서 1 : 1 몰비율로 접촉시킴을 특징으로 하는 피록시캄의 피르부테롤과의 1 : 1염의 제조방법.
  5. 이소프로테레놀과 피록시캄을 반응불활성 용매중에서 1 : 1 몰비율로 접촉시킴을 특징으로하는 피록시캄의 이소프로테레놀과의 1 : 1염의 제조방법.
  6. 트리마조신과 피록시캄을 반응불활성 용매중에서 1 : 1 몰비율로 접촉시킴을 특징으로 하는 피록시캄의 트리마조신과의 1 : 1염의 제조방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019850007443A 1984-10-11 1985-10-10 피록시캄염의 제조방법 KR870000277B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/659,733 US4567179A (en) 1984-10-11 1984-10-11 Antiinflammatory salts of piroxicam
US659,733 1984-10-11

Publications (2)

Publication Number Publication Date
KR860003248A true KR860003248A (ko) 1986-05-21
KR870000277B1 KR870000277B1 (ko) 1987-02-23

Family

ID=24646598

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019850007443A KR870000277B1 (ko) 1984-10-11 1985-10-10 피록시캄염의 제조방법

Country Status (25)

Country Link
US (1) US4567179A (ko)
EP (1) EP0178124B1 (ko)
JP (1) JPS6193182A (ko)
KR (1) KR870000277B1 (ko)
CN (1) CN1008062B (ko)
AT (1) ATE44147T1 (ko)
AU (1) AU553819B2 (ko)
CA (1) CA1240323A (ko)
DD (1) DD237658A5 (ko)
DE (1) DE3571132D1 (ko)
DK (1) DK463385A (ko)
EG (1) EG17673A (ko)
FI (1) FI82044C (ko)
GR (1) GR852457B (ko)
HU (1) HU193348B (ko)
IE (1) IE58722B1 (ko)
IL (1) IL76644A0 (ko)
NO (1) NO854033L (ko)
NZ (1) NZ213743A (ko)
PH (1) PH21594A (ko)
PL (1) PL255696A1 (ko)
PT (1) PT81279B (ko)
SU (1) SU1375136A3 (ko)
YU (1) YU44897B (ko)
ZA (1) ZA857785B (ko)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4812455A (en) * 1984-10-11 1989-03-14 Pfizer Inc. Antiinflammatory compositions and methods
US5260333A (en) * 1986-08-08 1993-11-09 Bristol Myers Squibb Company Effect of a combination of a terbutaline, diphenhydramine and ranitidine composition on gastrointestinal injury produced by nonsteroidal anti-inflammatory compositions
US6043259A (en) * 1998-07-09 2000-03-28 Medicure Inc. Treatment of cardiovascular and related pathologies
AU763464B2 (en) 1999-03-08 2003-07-24 Medicure Inc. Pyridoxal analogues for vitamin B-6 disorders
CA2376029A1 (en) * 1999-07-13 2001-01-18 Medicure Inc. Use of pyridoxin derivatives for the treatment of diabetes and related complications
CA2383252A1 (en) 1999-08-24 2001-03-01 Medicure International Inc. Treatment of cardiovascular related pathologies
US7442689B2 (en) * 2000-02-29 2008-10-28 Medicure International Inc. Cardioprotective phosphonates and malonates
JP2003525303A (ja) 2000-02-29 2003-08-26 メディキュア インターナショナル インコーポレイテッド 心臓保護ホスホン酸塩およびマロン酸塩
JP2003528146A (ja) 2000-03-28 2003-09-24 メディキュア インターナショナル インコーポレイテッド 脳血管疾患の治療
US6897228B2 (en) * 2000-07-07 2005-05-24 Medicure International Inc. Pyridoxine and pyridoxal analogues: new uses
US6548519B1 (en) 2001-07-06 2003-04-15 Medicure International Inc. Pyridoxine and pyridoxal analogues: novel uses
WO2002004421A2 (en) 2000-07-07 2002-01-17 Medicure International Inc. Pyridoxine and pyridoxal analogues: cardiovascular therapeutics
US20040121988A1 (en) * 2001-03-28 2004-06-24 Medicure International Inc. Treatment of cerebrovascular disease
US20040186077A1 (en) * 2003-03-17 2004-09-23 Medicure International Inc. Novel heteroaryl phosphonates as cardioprotective agents
WO2006002549A1 (en) * 2004-07-07 2006-01-12 Medicure International Inc. Combination therapies employing platelet aggregation drugs
US20070060549A1 (en) * 2004-08-10 2007-03-15 Friesen Albert D Combination therapies employing ace inhibitors and uses thereof for the treatment of diabetic disorders
US20060094749A1 (en) * 2004-10-28 2006-05-04 Medicure International Inc. Substituted pyridoxines as anti-platelet agents
AU2005304220A1 (en) * 2004-10-28 2006-05-18 Medicure International Inc. Dual antiplatelet/anticoagulant pyridoxine analogs
US7459468B2 (en) * 2004-10-28 2008-12-02 Medicure International, Inc. Aryl sulfonic pyridoxines as antiplatelet agents
CA2632090A1 (en) * 2005-11-28 2007-05-31 Medicure International Inc. Selected dosage for the treatment of cardiovascular and related pathologies

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4230717A (en) * 1978-12-29 1980-10-28 Lovelace Alan M Administrator Indomethacin-antihistamine combination for gastric ulceration control
US4374843A (en) * 1980-10-14 1983-02-22 Pfizer Inc. 2-Guanidino-4-heteroarylthiazoles
US4434163A (en) * 1981-06-01 1984-02-28 Pfizer Inc. Water-soluble benzothiazine dioxide salts
CY1398A (en) * 1981-09-04 1987-12-18 Glaxo Group Ltd Pharmaceutical compositions containing non-steroidal anti-inflammatory agents
BE894286A (fr) * 1981-09-04 1983-03-02 Glaxo Group Ltd Composition pharmaceutique contenant un medicament anti-inflammatoire systemique non steroidique et du 1-methyl-5-((3-(3-(1-piperidinylmethyl)phenoxy)-propyl)amino -1h-1,2,4-triazole-3-methanol ou un sel de ce compose

Also Published As

Publication number Publication date
PT81279B (pt) 1988-02-17
GR852457B (ko) 1986-02-11
FI853946L (fi) 1986-04-12
EP0178124B1 (en) 1989-06-21
FI82044C (fi) 1991-01-10
DE3571132D1 (en) 1989-07-27
AU4848485A (en) 1986-04-17
HU193348B (en) 1987-09-28
HUT38539A (en) 1986-06-30
PH21594A (en) 1987-12-11
JPH0442387B2 (ko) 1992-07-13
FI82044B (fi) 1990-09-28
IL76644A0 (en) 1986-02-28
ATE44147T1 (de) 1989-07-15
YU161685A (en) 1987-12-31
KR870000277B1 (ko) 1987-02-23
NZ213743A (en) 1988-11-29
PL255696A1 (en) 1986-07-29
CN85107498A (zh) 1986-07-02
ZA857785B (en) 1987-05-27
SU1375136A3 (ru) 1988-02-15
IE852498L (en) 1986-04-11
NO854033L (no) 1986-04-14
PT81279A (en) 1985-11-01
DK463385A (da) 1986-04-12
AU553819B2 (en) 1986-07-31
DK463385D0 (da) 1985-10-10
JPS6193182A (ja) 1986-05-12
YU44897B (en) 1991-04-30
CN1008062B (zh) 1990-05-23
CA1240323A (en) 1988-08-09
US4567179A (en) 1986-01-28
FI853946A0 (fi) 1985-10-10
IE58722B1 (en) 1993-11-03
EG17673A (en) 1990-08-30
DD237658A5 (de) 1986-07-23
EP0178124A1 (en) 1986-04-16

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