KR860000293A - 함암작용을 갖는 푸란유도체의 제조방법 - Google Patents

함암작용을 갖는 푸란유도체의 제조방법 Download PDF

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KR860000293A
KR860000293A KR1019850003938A KR850003938A KR860000293A KR 860000293 A KR860000293 A KR 860000293A KR 1019850003938 A KR1019850003938 A KR 1019850003938A KR 850003938 A KR850003938 A KR 850003938A KR 860000293 A KR860000293 A KR 860000293A
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빈센티이스 레오나르도데
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아메테오데 빈센티이스
아우소니아 파르마세우티시 에스. 알. 엘
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Abstract

내용 없음

Description

항암작용을 갖는 푸란유도체의 제조방법.
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (4)

  1. 하기 반응공정에 의하여, 2-(디메틸아미노메틸)-5-(메틸-X)푸란(Ⅱ)을 화합물(Ⅲ)과 반응시킴을 특징으로 하는 하기 일반식(Ⅰ)의 화합물 제조방법.
    [상기 식중, A는 CH-NO2기 또는 N-CN기이고, B는 CH2기, 산소 또는 황원자, 또는 단일 결합이고, R는 완전히 방향족이거나 부분적으로 또는 전체적으로 수소화 될 수 있는 비시플릭 또는 플리시클릭잔기이고, 이 잔기는 탄소원자 대신에 1개이상의 질소, 산소 또는 황 원자를 임으로 함유하고, 다음과 같은 치환체들을 1개이상 가지며, 즉 -작쇄 또는 측쇄를 갖는 C1-C4알킬기, C2-C4알케닐 또는 알케닐기(여기에서, 사슬은 산소, 질소 또는 황 원자에 의해서 임의로 단속되고, OH,SH,NH2,NO2기 또는 할로겐 원자들과 같은 치환체를 가짐). -C1-C4아미노, 모노아미노 또는 디알킬 아미노기, 피롤리디노, 피페리디노, 피페리지노 또는 모르폴리노기, C1-C4알콕시 또는 알킬메르캅토기, CN, NO2,COOH기, 할로겐원자들, -1개 이상의 R3ODH2CH|2O-기(여기에서, R3는 C1-C4즉쇄 또는 측쇄알킬기임)를 갖는 페닐기, R1과 R2는 서로 동일하거나 또는 상이한 것으로서 수소 또는 C1-C4알킬이고, n과 m은 서로 동일하거나 또는 상이한 것으로서 0,1,2,3 또는 4이고, 단 B가 CH2,A가 CH-NO2, m과 n가 0인 경우에 R은 3,4-메틸렌디옥시페닐과는 잔기이고, X는 OH,N(CH3)3기 또는 할로겐 원자와 같은 이탈기임]
  2. 하기 화합물(Ⅱ)를 처음에 하기 일반식의 우레아 또는 티오우레아와 반응시키고, 이어서 니트로메틴 또는 시안아미드와 반응시킴을 특징으로 하는 일반식(Ⅰ)의 화합물의 제조방법.
    [상기 식중, A,B,R,R1,R2,m,n 및 x는 상기의 의미를 갖고, M은 산소 또는 황임]
  3. 하기화합물(ⅩⅦ)를 아민(Ⅴ)과 반응시킴을 특징으로 하는 일반식(Ⅰ)의 화합물의 제조방법.
    [상기 식중, A,B,R,R1,R2,m,n 및 x는 상기의 의미를 가짐]
  4. 하기 일반식의 화합물(ⅩⅧ)을 화합물(Ⅶ)과 반응시킴을 특징으로 하는 일반식(Ⅰ)의 화합물의 제조방법
    [상기 식중, Y는 히드록시 또는 토실옥시기임]
    [상기식중 A,B,R,R1,R2,m,n 및 x는 상기의 의미를 가짐]
    ※ 참고사항 : 최초출원내용에 의하여 공개하는 것임.
KR1019850003938A 1984-06-06 1985-06-05 함암작용을 갖는 푸란유도체의 제조방법 KR860000293A (ko)

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IT21273/84A IT1196133B (it) 1984-06-06 1984-06-06 Derivati furanici con attivita' antiulcera
IT21273A/84 1984-06-06

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KR860000293A true KR860000293A (ko) 1986-01-27

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EP (1) EP0164040A3 (ko)
JP (1) JPS6117578A (ko)
KR (1) KR860000293A (ko)
AU (1) AU4318585A (ko)
ES (1) ES8705412A1 (ko)
IT (1) IT1196133B (ko)
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JP2002529503A (ja) * 1998-11-17 2002-09-10 ニトロメッド，インク． ニトロソ化及びニトロシル化ｈ２リセプターアンタゴニスト化合物及び組成物並びにその利用方法
CN101133036B (zh) * 2004-09-30 2010-10-13 詹森药业有限公司 可用作选择性雄激素受体调节剂(sarms)的新苯并咪唑衍生物
EP1893612B1 (en) * 2005-06-22 2011-08-03 Plexxikon, Inc. Pyrrolo [2, 3-b]pyridine derivatives as protein kinase inhibitors
WO2008063888A2 (en) 2006-11-22 2008-05-29 Plexxikon, Inc. Compounds modulating c-fms and/or c-kit activity and uses therefor
PE20081581A1 (es) * 2006-12-21 2008-11-12 Plexxikon Inc COMPUESTOS PIRROLO[2,3-b]PIRIDINAS COMO MODULADORES DE QUINASA
WO2008079909A1 (en) * 2006-12-21 2008-07-03 Plexxikon, Inc. Pyrrolo [2,3-b] pyridines as kinase modulators
WO2009012283A1 (en) 2007-07-17 2009-01-22 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
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EA028821B9 (ru) 2011-02-07 2018-10-31 Плексксикон, Инк. Соединения и способы для модуляции киназ, а также показания к их применению
TWI558702B (zh) 2011-02-21 2016-11-21 普雷辛肯公司 醫藥活性物質的固態形式
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EP0164040A3 (en) 1987-07-01
ES8705412A1 (es) 1987-05-01
IT8421273A1 (it) 1985-12-06
IT8421273A0 (it) 1984-06-06
ZA854301B (en) 1986-01-29
ES543448A0 (es) 1987-05-01
JPS6117578A (ja) 1986-01-25
IT1196133B (it) 1988-11-10
EP0164040A2 (en) 1985-12-11
AU4318585A (en) 1985-12-12
US4634701A (en) 1987-01-06

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