KR860000065A - 국부적이고 계통적인 약물의 경피 및 전위막 침투를 증강시키는 조성물 및 방법 - Google Patents

국부적이고 계통적인 약물의 경피 및 전위막 침투를 증강시키는 조성물 및 방법 Download PDF

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KR860000065A
KR860000065A KR1019850004121A KR850004121A KR860000065A KR 860000065 A KR860000065 A KR 860000065A KR 1019850004121 A KR1019850004121 A KR 1019850004121A KR 850004121 A KR850004121 A KR 850004121A KR 860000065 A KR860000065 A KR 860000065A
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composition
active substance
compound
carbon atoms
alkyl group
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KR1019850004121A
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미레조브스키 도라 (외 1)
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스튜어트 알. 슈터
알레르겐 파머슈티칼, 인크
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Publication of KR860000065A publication Critical patent/KR860000065A/ko

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

내용 없음

Description

국부적이고 계통적인 약물의 경피 및 전위막 침투를 증강시키는 조성물 및 방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (16)

  1. m이 4 내지 9이고; R1이 수소이거나 1 내지 8개의 탄소원자를 갖는 알킬그룹이고; R은 1 내지 20개의 탄소원자를 갖는 직쇄 또는 측쇄 알킬그룹인 구조식,
    을 갖는 화합물의 비독성 침투량과 약리학적 활성물질의 효과적인 양으로 구성되는 약리학적 활성물질의 경피 및 전위막 침투를 증강시키는 극소적 조성물.
  2. 활성물질이 항생제인 청구범위 제1항의 조성물.
  3. m이 4 내지 6이고, R1이 수소이고, R이 1 내지 20인 청구범위 제2항의 화합물.
  4. m이 6이고, R1이 수소이고, R은 운데실이며, 그 화합물이 헥사메틸렌라우르 아미드인 청구범위 제3항의 조성물.
  5. 항생물질이 에리트로마이신 및 린크 마이신으로 구성되는 그룹으로부터 선택되는 청구범위 제2항의 조성물.
  6. 활성물질이 항진균제인 청구범위 제1항의 조성물.
  7. 활성물질이 스테로이드인 청구범위 제1항의 조성물.
  8. m이 4 내지 9이고; R1이 수소이거나 1 내지 8개의 탄소원자를 갖는 알킬그룹이며; R은 1 내지 20개의 탄소원자를 갖는 직쇄 또는 측쇄 알킬그룹인 구조식,
    을 갖는 화합물의 침투량과 약리학적 활성물질의 유효량으로 구성되는 조성물을 인간이나 동물에 극부적으로 투여하는 것으로 구성되는 약리학적 활성물질의 경피 및 전위막 침투를 증강시키는 방법.
  9. 활성물질의 항생제인 청구범위 제8항의 방법.
  10. 활성물질의 항진균제인 청구범위 제8항의 방법.
  11. 활성물질이 스테로이드인 청구범위 제8항의 방법.
  12. m이 6이고, R1이 운데실이며, 그 화합물이 헥사메틸렌라우르 아미드인 청구범위 제8항의 방법.
  13. m이 4 내지 9이고, R1이 수소이거나, 1 내지 8개의 탄소원자를 갖는 알킬그룹이고, R은 1 내지 20개의 탄소원자를 갖는 직쇄 또는 측쇄알킬 그룹인 구조식,
    을 갖는 화합물의 비독성 침투량을 비독성 제약상 담체와 혼합하는 것으로 구성되는 약리학적 활성물질의 경피 및 전위막 침투를 증강시키는 극소적 조성물을 제조하는 방법.
  14. 상기 조성물이 용액인 청구범위 제13항의 방법.
  15. 상기 조성물이 크림인 청구범위 제13항의 방법.
  16. 상기 조성물이 연고인 청구범위 제13항의 방법.
    ※ 참고사항 : 최초출원내용에 의하여 공개하는 것임.
KR1019850004121A 1984-06-13 1985-06-12 국부적이고 계통적인 약물의 경피 및 전위막 침투를 증강시키는 조성물 및 방법 KR860000065A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/620,229 US4743588A (en) 1984-06-13 1984-06-13 Compositions and methods of enhancing transdermal and transmembrane penetration systemic agents
US620229 1996-03-22

Publications (1)

Publication Number Publication Date
KR860000065A true KR860000065A (ko) 1986-01-25

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ID=24485099

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Application Number Title Priority Date Filing Date
KR1019850004121A KR860000065A (ko) 1984-06-13 1985-06-12 국부적이고 계통적인 약물의 경피 및 전위막 침투를 증강시키는 조성물 및 방법

Country Status (16)

Country Link
US (1) US4743588A (ko)
EP (1) EP0164998A3 (ko)
JP (1) JPS611623A (ko)
KR (1) KR860000065A (ko)
AU (1) AU582364B2 (ko)
CA (1) CA1255594A (ko)
DK (1) DK259485A (ko)
EG (1) EG17345A (ko)
FI (1) FI852331L (ko)
GR (1) GR851421B (ko)
HU (1) HU193774B (ko)
IL (1) IL75488A (ko)
NZ (1) NZ212368A (ko)
PT (1) PT80625B (ko)
ZA (1) ZA854365B (ko)
ZW (1) ZW9985A1 (ko)

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WO1987004594A1 (en) * 1986-01-31 1987-08-13 Nelson Research And Development Company Compositions comprising 1-substituted azacycloalkanes and their uses
CA1298557C (en) * 1986-01-31 1992-04-07 Whitby Research Incorporated Compositions comprising 1-substituted azacyclo-alkanes
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CA1308352C (en) * 1986-08-15 1992-10-06 James V. Peck Compositions comprising 1-oxohydrocarbyl-substituted azacyclohexanes
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EP0268219A1 (en) * 1986-11-19 1988-05-25 Whitby Research Incorporated Penetration enhancers for transdermal delivery of systemic agents
US5112804A (en) * 1987-04-01 1992-05-12 Temple University Of The Commonwealth System Of Higher Education Pharmaceutical composition and method of intranasal administration
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CA1334646C (en) * 1988-04-08 1995-03-07 James Vanolden Peck Transdermal penetration enhancers
EP0425505B1 (en) * 1988-06-30 1993-03-17 The Upjohn Company Transdermal antisecretory agents for gastrointestinal disease
US5059603A (en) * 1989-06-12 1991-10-22 Centuries Laboratories, Inc. Method and composition for treating impotence
US5981591A (en) * 1992-12-04 1999-11-09 Mayor Pharmaceutical Laboratories, Inc. Sprayable analgesic composition and method of use
US6767925B1 (en) 1996-10-31 2004-07-27 Joseph A. Deihl Sprayable analgesic composition and method of use
US6797276B1 (en) * 1996-11-14 2004-09-28 The United States Of America As Represented By The Secretary Of The Army Use of penetration enhancers and barrier disruption agents to enhance the transcutaneous immune response
US20060002949A1 (en) * 1996-11-14 2006-01-05 Army Govt. Of The Usa, As Rep. By Secretary Of The Office Of The Command Judge Advocate, Hq Usamrmc. Transcutaneous immunization without heterologous adjuvant
US20060002959A1 (en) * 1996-11-14 2006-01-05 Government Of The United States Skin-sctive adjuvants for transcutaneous immuization
US5980898A (en) * 1996-11-14 1999-11-09 The United States Of America As Represented By The U.S. Army Medical Research & Material Command Adjuvant for transcutaneous immunization
IL136042A (en) 1997-11-10 2005-12-18 Cellegy Pharma Inc Alcohol-containing composition for topical application
US20040258703A1 (en) * 1997-11-14 2004-12-23 The Government Of The Us, As Represented By The Secretary Of The Army Skin-active adjuvants for transcutaneous immunization
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JP4932086B2 (ja) * 1999-04-08 2012-05-16 インターセル ユーエスエイ、インコーポレイテッド 経皮的免疫のための乾燥製剤
AU2002250071B2 (en) * 2001-02-13 2008-02-14 Government Of The United States, As Represented By The Secretary Of The Army Vaccine for transcutaneous immunization
US6521613B2 (en) 2001-04-10 2003-02-18 Allergan, Inc. Lactam compounds for penetration enhancement
US20030175329A1 (en) * 2001-10-04 2003-09-18 Cellegy Pharmaceuticals, Inc. Semisolid topical hormonal compositions and methods for treatment
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ZA854365B (en) 1986-05-28
US4743588A (en) 1988-05-10
JPS611623A (ja) 1986-01-07
EG17345A (en) 1991-03-30
GR851421B (ko) 1985-11-25
AU4345285A (en) 1985-12-19
FI852331L (fi) 1985-12-14
HU193774B (en) 1987-11-30
PT80625B (en) 1987-03-26
EP0164998A3 (en) 1987-06-16
FI852331A0 (fi) 1985-06-12
IL75488A (en) 1989-07-31
DK259485D0 (da) 1985-06-10
PT80625A (en) 1985-07-01
DK259485A (da) 1985-12-14
CA1255594A (en) 1989-06-13
ZW9985A1 (en) 1985-09-04
EP0164998A2 (en) 1985-12-18
AU582364B2 (en) 1989-03-23
HUT38543A (en) 1986-06-30
NZ212368A (en) 1988-03-30

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