KR850003725A - 메틸-피페라진 유도체의 제조방법 - Google Patents
메틸-피페라진 유도체의 제조방법 Download PDFInfo
- Publication number
- KR850003725A KR850003725A KR1019840007162A KR840007162A KR850003725A KR 850003725 A KR850003725 A KR 850003725A KR 1019840007162 A KR1019840007162 A KR 1019840007162A KR 840007162 A KR840007162 A KR 840007162A KR 850003725 A KR850003725 A KR 850003725A
- Authority
- KR
- South Korea
- Prior art keywords
- methyl
- piperazine
- piperazine derivative
- preparing methyl
- reacted
- Prior art date
Links
- PVOAHINGSUIXLS-UHFFFAOYSA-N 1-Methylpiperazine Chemical class CN1CCNCC1 PVOAHINGSUIXLS-UHFFFAOYSA-N 0.000 title 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- IFNWESYYDINUHV-UHFFFAOYSA-N 2,6-dimethylpiperazine Chemical compound CC1CNCC(C)N1 IFNWESYYDINUHV-UHFFFAOYSA-N 0.000 claims 1
- JOMNTHCQHJPVAZ-UHFFFAOYSA-N 2-methylpiperazine Chemical compound CC1CNCCN1 JOMNTHCQHJPVAZ-UHFFFAOYSA-N 0.000 claims 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- DVECBJCOGJRVPX-UHFFFAOYSA-N butyryl chloride Chemical compound CCCC(Cl)=O DVECBJCOGJRVPX-UHFFFAOYSA-N 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 239000012442 inert solvent Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000003960 organic solvent Substances 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pain & Pain Management (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (1)
- 2-메틸-피페라진 또는 2,6-디메틸-피페라진 각각을 불활성 유기 용매중에서 신나밀 클로라이드와 반응시키고; 이와 같이 수득된 신나밀-피페라진 중간체를 10내지 100℃에서 염산수용액체 존재하에 무수환경중, 불활성 용매중에서 부티릴 클로라이드와 반응시킴을 특징으로 하여, 일반식(Ⅰ)의 화합물 또는 약리학적으로 허용가능한 그의 산부가염을 제조하는 방법.상기식에서, R은 수소 또는 메틸이고, 이때 적어도 하나의 R은 메틸이다.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT???23720A/83 | 1983-11-15 | ||
| IT8323720A IT1207990B (it) | 1983-11-15 | 1983-11-15 | Attivita' analgesica, processo per derivati metil-piperazinici edla loro preparazione e composizioni terapeutiche che li contengono. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR850003725A true KR850003725A (ko) | 1985-06-26 |
Family
ID=11209419
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019840007162A KR850003725A (ko) | 1983-11-15 | 1984-11-15 | 메틸-피페라진 유도체의 제조방법 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US4562191A (ko) |
| EP (1) | EP0142756A3 (ko) |
| JP (1) | JPS60116671A (ko) |
| KR (1) | KR850003725A (ko) |
| IT (1) | IT1207990B (ko) |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2882271A (en) * | 1959-04-14 | Xcixcxh | ||
| US3318876A (en) * | 1962-12-11 | 1967-05-09 | Lepetit Spa | Substituted piperazines and process for preparing same |
| FR1397193A (fr) * | 1963-12-06 | 1965-04-30 | Lepetit Spa | Procédé de préparation de nouveaux dérivés de la pipérazine |
| FR7170M (ko) * | 1966-12-28 | 1969-08-11 | ||
| JPS4986382A (ko) * | 1972-12-26 | 1974-08-19 | ||
| JPS52286A (en) * | 1975-05-27 | 1977-01-05 | Kyorin Pharmaceut Co Ltd | Method of preparing 1-(3-phenylpropyl)-4-acylpiperazine derivatives |
| SE411347B (sv) * | 1975-05-27 | 1979-12-17 | Kyorin Seiyaku Kk | Forfarande for framstellning av 1-(3-fenylpropyl)-4-(beta-alkoxiakryloyl)-piperazinderivat |
| FR2387971A1 (fr) * | 1977-04-19 | 1978-11-17 | Delalande Sa | Nouvelles trimethoxy cinnamoyles piperazines, leur procede de preparation et leur application en therapeutique |
| US4368199A (en) * | 1980-01-21 | 1983-01-11 | Delalande S.A. | Novel derivatives of 3,4,5-trimethoxy cinnamoyl piperazine, their salts, the process for preparing the same and their application in therapeutics |
| US4492698A (en) * | 1980-06-16 | 1985-01-08 | Bjoerk Anders K | Diphenylbutyl-1-acylpiperazines |
-
1983
- 1983-11-15 IT IT8323720A patent/IT1207990B/it active
-
1984
- 1984-11-02 US US06/667,714 patent/US4562191A/en not_active Expired - Fee Related
- 1984-11-02 EP EP84113225A patent/EP0142756A3/en not_active Withdrawn
- 1984-11-15 JP JP59239579A patent/JPS60116671A/ja active Pending
- 1984-11-15 KR KR1019840007162A patent/KR850003725A/ko not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| US4562191A (en) | 1985-12-31 |
| IT1207990B (it) | 1989-06-01 |
| IT8323720A0 (it) | 1983-11-15 |
| JPS60116671A (ja) | 1985-06-24 |
| EP0142756A2 (en) | 1985-05-29 |
| EP0142756A3 (en) | 1986-02-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| WITN | Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid |