KR850003412A - Improved Condensation Method of Amino Acids and 5beta-Cholic Acid - Google Patents

Improved Condensation Method of Amino Acids and 5beta-Cholic Acid Download PDF

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Publication number
KR850003412A
KR850003412A KR1019830004733A KR830004733A KR850003412A KR 850003412 A KR850003412 A KR 850003412A KR 1019830004733 A KR1019830004733 A KR 1019830004733A KR 830004733 A KR830004733 A KR 830004733A KR 850003412 A KR850003412 A KR 850003412A
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South Korea
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beta
alpha
acid
amino acids
collanoic
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KR1019830004733A
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Korean (ko)
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KR860000346B1 (en
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지영수
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지영수
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Publication of KR860000346B1 publication Critical patent/KR860000346B1/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Steroid Compounds (AREA)

Abstract

내용 없음No content

Description

아미노산과 5베타-콜라닉 산의 개량된 축합방법Improved Condensation Method of Amino Acids and 5beta-Cholic Acid

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음As this is a public information case, the full text was not included.

Claims (5)

펩티드커플링시약 존재하에서 아미노산의 염(III)과 3알파, 7베타-디하이드록시-5베타-콜라노익산(IV)을 반응시켜 불순물을 함유하는 아미노산이 축합된 3알파, 7베타-디하이록시-5베타-콜라노익산의 염(VIII)을 제조한 후, 정제하여 3알파, 7베타-디하이드록시-5베타-콜라노익산의 아미노산 축합물(V)을 제조하는 방법.In the presence of a peptide coupling reagent, salts of amino acids (III) and 3 alpha, 7 beta-dihydroxy-5 beta-collanoic acid (IV) are reacted to form 3 alpha, 7 beta-di condensed amino acids containing impurities. A method for preparing an amino acid condensate (V) of 3 alpha, 7 beta-dihydroxy-5 beta-collanoic acid by preparing a salt of hydroxy-5 beta-collanoic acid (VIII), followed by purification. 제1항에 있어서, 펩티드커플링시약으로는 EEDQ(VI)를 사용하는 방법.The method of claim 1, wherein EEDQ (VI) is used as the peptide coupling reagent. 제1항에 있어서, 아미노산염으로 TEA를 사용하여 아미노산의 TEA염(III)으로 하는 방법.The method according to claim 1, wherein TEA is used as the amino acid salt to form TEA salt (III). 제1항에 있어서, 아미노산염과 3알파, 7베타-디하이드록시-5베타-콜라노익산(IV)의 반응시에 어프로틱용매인 DMF 용매내에서 반응시키는 방법.The method according to claim 1, wherein the reaction of the amino acid salt with 3 alpha and 7 beta-dihydroxy-5 beta-collanoic acid (IV) is carried out in a DMF solvent which is an aprotic solvent. 제1항에 있어서, 정제방법은 불순물을 함유한 아미노산이 축합된 3알파, 7베타-디하이드록시-5베타-콜라노익산의 염(VIII)을 CH2Cl2이 용해시킨 후, 건조염화수소 가스를 통과시켜 아미노산이 축합된 3알파, 7베타-L하이드록시-5베타-콜라노익산 베이스(V)로 정제하는 방법.The method of claim 1, wherein the purification method comprises drying hydrogen chloride after CH 2 Cl 2 dissolves a salt (VIII) of 3 alpha, 7 beta-dihydroxy-5 beta-collanoic acid condensed with an amino acid containing impurities. Purifying with 3 alpha, 7 beta-L hydroxy-5 beta-collanoic acid base (V) in which amino acids are condensed through a gas. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019830004733A 1983-10-06 1983-10-06 3alpha.7beta-dihydroxy-5beta-cholanoic acid KR860000346B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019830004733A KR860000346B1 (en) 1983-10-06 1983-10-06 3alpha.7beta-dihydroxy-5beta-cholanoic acid

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019830004733A KR860000346B1 (en) 1983-10-06 1983-10-06 3alpha.7beta-dihydroxy-5beta-cholanoic acid

Publications (2)

Publication Number Publication Date
KR850003412A true KR850003412A (en) 1985-06-17
KR860000346B1 KR860000346B1 (en) 1986-04-12

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KR1019830004733A KR860000346B1 (en) 1983-10-06 1983-10-06 3alpha.7beta-dihydroxy-5beta-cholanoic acid

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KR860000346B1 (en) 1986-04-12

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