KR850000973A - 아클라루비신 또는 이의 염산염의 유성 조성물의 제조방법 - Google Patents

아클라루비신 또는 이의 염산염의 유성 조성물의 제조방법 Download PDF

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Publication number
KR850000973A
KR850000973A KR1019840004123A KR840004123A KR850000973A KR 850000973 A KR850000973 A KR 850000973A KR 1019840004123 A KR1019840004123 A KR 1019840004123A KR 840004123 A KR840004123 A KR 840004123A KR 850000973 A KR850000973 A KR 850000973A
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KR
South Korea
Prior art keywords
aclarubicin
fatty acids
hydrochloride salt
oily composition
hydrochloride
Prior art date
Application number
KR1019840004123A
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English (en)
Other versions
KR910002638B1 (ko
Inventor
히로이쓰 가와다 (외 6)
Original Assignee
모리오까 시게오
야마도우찌 세이야꾸 가부시끼 가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by 모리오까 시게오, 야마도우찌 세이야꾸 가부시끼 가이샤 filed Critical 모리오까 시게오
Publication of KR850000973A publication Critical patent/KR850000973A/ko
Application granted granted Critical
Publication of KR910002638B1 publication Critical patent/KR910002638B1/ko

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12Carboxylic acids; Salts or anhydrides thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cosmetics (AREA)

Abstract

내용 없음

Description

아클라루비신 또는 이의 염산염의 유성 조성물의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
본 도표는 Ⅰ군 내지 Ⅴ군에 대한 암성포의 크기변화 및 괴사율을 나타낸 것이다.

Claims (2)

  1. 아클라루비신 또는 아클라루비신 염산염을, 포화중쇄지방산, 불포화 중쇄 지방산 및 불포화 장쇄 지방산 중에서 선택된 하나 이상의 지방산 및 요오드화유 및 식물성유 중에서 선택된 하나 이상의 지방 및 오일에 용해시킴을 특징으로 하는, 아클라루비신 또는 이의 염산염의 유성 조성물의 제조방법.
  2. 제1항에 있어서, 지방산의 배합비가 아클라-루비신 염산염 1중량부당 10 내지 1,000 중량부 이거나, 아클라루비신 1중량부당 1 내지 1,000 중량부인 방법.
    ※참고사항 : 최초출원 내요에 의하여 공개하는 것임.
KR1019840004123A 1983-07-13 1984-07-13 아클라루비신 또는 이의 염산염의 유성 조성물의 제조방법 KR910002638B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP58127092A JPS6028916A (ja) 1983-07-13 1983-07-13 アクラルビシンまたはその塩酸塩の油性組成物
JP127092/83 1983-07-13
JP58-127092 1983-07-13

Publications (2)

Publication Number Publication Date
KR850000973A true KR850000973A (ko) 1985-03-14
KR910002638B1 KR910002638B1 (ko) 1991-04-27

Family

ID=14951379

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019840004123A KR910002638B1 (ko) 1983-07-13 1984-07-13 아클라루비신 또는 이의 염산염의 유성 조성물의 제조방법

Country Status (6)

Country Link
US (1) US4772590A (ko)
EP (1) EP0132105B1 (ko)
JP (1) JPS6028916A (ko)
KR (1) KR910002638B1 (ko)
DE (1) DE3483500D1 (ko)
ES (1) ES8602410A1 (ko)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61189215A (ja) * 1985-02-18 1986-08-22 Teijin Ltd 5−フルオロ−2′−デオキシウリジンエステル類の油状医薬組成物
WO1993005774A1 (en) * 1991-09-25 1993-04-01 Wisconsin Alumni Research Foundation Complexes of anthracycline antibiotics with polyunsaturated fatty acids in lipid emulsions
US6426367B1 (en) * 1999-09-09 2002-07-30 Efa Sciences Llc Methods for selectively occluding blood supplies to neoplasias
US20060034878A1 (en) * 2004-08-16 2006-02-16 Satterfield Artus L Iodized oil

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH229981A (de) * 1939-02-08 1943-11-30 Knoll Ag Verfahren zur Herstellung einer strychninoxydhaltigen Lösung.
JPS5134915B2 (ko) * 1974-07-27 1976-09-29
FR2498075B2 (fr) * 1980-01-25 1985-07-12 Oreal Solution stable a l'oxydation d'un acide gras essentiel ou d'un melange de ces acides et compositions cosmetiques la contenant
DE3105483A1 (de) * 1981-02-14 1982-09-09 Behringwerke Ag, 3550 Marburg "verwendung von aclacinomycin als immunsuppressivum"
US4578391A (en) * 1982-01-20 1986-03-25 Yamanouchi Pharmaceutical Co., Ltd. Oily compositions of antitumor drugs

Also Published As

Publication number Publication date
JPH0463048B2 (ko) 1992-10-08
JPS6028916A (ja) 1985-02-14
DE3483500D1 (de) 1990-12-06
ES534261A0 (es) 1985-11-16
US4772590A (en) 1988-09-20
KR910002638B1 (ko) 1991-04-27
ES8602410A1 (es) 1985-11-16
EP0132105A2 (en) 1985-01-23
EP0132105B1 (en) 1990-10-31
EP0132105A3 (en) 1986-08-27

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