KR840009059A - Manufacturing method of 1,8-dihydroxy-10-acyl-9-anthrones - Google Patents

Manufacturing method of 1,8-dihydroxy-10-acyl-9-anthrones Download PDF

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Publication number
KR840009059A
KR840009059A KR1019840002278A KR840002278A KR840009059A KR 840009059 A KR840009059 A KR 840009059A KR 1019840002278 A KR1019840002278 A KR 1019840002278A KR 840002278 A KR840002278 A KR 840002278A KR 840009059 A KR840009059 A KR 840009059A
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KR
South Korea
Prior art keywords
dihydroxy
anthrones
acyl
acid chloride
manufacturing
Prior art date
Application number
KR1019840002278A
Other languages
Korean (ko)
Inventor
주하니 카이리살로(외 2) 페카
Original Assignee
안티케레넨 파시 살로캉가스
오리온 위티머 오위
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Application filed by 안티케레넨 파시 살로캉가스, 오리온 위티머 오위 filed Critical 안티케레넨 파시 살로캉가스
Publication of KR840009059A publication Critical patent/KR840009059A/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
    • C07C49/723—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups polycyclic
    • C07C49/727—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups polycyclic a keto group being part of a condensed ring system
    • C07C49/737—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups polycyclic a keto group being part of a condensed ring system having three rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
    • C07C49/747—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups containing six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Dermatology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Cosmetics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Compositions Of Macromolecular Compounds (AREA)

Abstract

내용 없음No content

Description

1,8-디하이드록시-10-아실-9-안트론류의 제조방법Manufacturing method of 1,8-dihydroxy-10-acyl-9-anthrones

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

Claims (4)

다음구조식의 1,8-디하이드록시-9-안트론1,8-dihydroxy-9-anthrone of the formula 을 구조식 RCOCI (여기에서 R은 탄소수 2-4의 알킬기이다)의 산클로라이드와 반응시켜서 다음구조식의 1,8-디하이드록시-10-아실-9-안트론류1,8-dihydroxy-10-acyl-9-anthrones of the following structure by reacting with an acid chloride of the formula RCOCI, wherein R is an alkyl group having 2-4 carbon atoms. 상기식에서 R은 전술한 바와 같다.In which R is as described above. 를 제조함에 있어서, 반응을 2,4-디메틸피리딘의 존재하여 행함을 특징으로 하는 건선치료에 사용되는 1,8-디하이드록시-10-아실-9-안트론류를 제조하는 방법.A method for preparing 1,8-dihydroxy-10-acyl-9-anthrones for use in treating psoriasis, characterized in that the reaction is carried out in the presence of 2,4-dimethylpyridine. 제1항에서, 용매로 톨루엔, 키실렌 또는 디클로로메탄이나 테트라클로로 에탄과 같은 염소화 탄화수소를 사용하는 것을 특징으로 하는 방법.A process according to claim 1, wherein toluene, xylene or chlorinated hydrocarbons such as dichloromethane or tetrachloroethane are used as the solvent. 제1항에서, 산클로라이드를 100％의 초과량을 사용하는 것을 특징으로 하는 방법.A process according to claim 1, wherein an excess of 100% of acid chloride is used. 제1항에서, 반응온도를 -10℃내지 +20℃를 사용하고, 산클로라이드를 2시간정도에 결쳐서 가하고 교반을 2시간 이상 더 행함을 특징으로 하는 방법.The method according to claim 1, wherein the reaction temperature is -10 ° C to + 20 ° C, acid chloride is added in about 2 hours, and stirring is further performed for 2 hours or more. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019840002278A 1983-05-18 1984-04-27 Manufacturing method of 1,8-dihydroxy-10-acyl-9-anthrones KR840009059A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FI831739A FI66585C (en) 1983-05-18 1983-05-18 FOERFARANDE FOER FRAMSTAELLNING AV SAERSKILT VID BEHANDLING AVSORIASIS ANVAENDBARA 1,8-DIHYDROXI-10-ACYL-9-ANTRONER
FI831739 1983-05-18

Publications (1)

Publication Number Publication Date
KR840009059A true KR840009059A (en) 1984-12-24

Family

ID=8517222

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019840002278A KR840009059A (en) 1983-05-18 1984-04-27 Manufacturing method of 1,8-dihydroxy-10-acyl-9-anthrones

Country Status (31)

Country Link
JP (1) JPS59212443A (en)
KR (1) KR840009059A (en)
AU (1) AU560079B2 (en)
BE (1) BE899334A (en)
CA (1) CA1212943A (en)
CH (1) CH659464A5 (en)
CS (1) CS256379B2 (en)
DD (1) DD223702A5 (en)
DE (1) DE3418382A1 (en)
DK (1) DK154207C (en)
ES (1) ES8505167A1 (en)
FI (1) FI66585C (en)
FR (1) FR2546162B1 (en)
GB (1) GB2140007B (en)
GR (1) GR79971B (en)
HU (1) HUT36076A (en)
IL (1) IL71446A (en)
IN (1) IN156115B (en)
IS (1) IS2902A7 (en)
IT (1) IT1173473B (en)
LU (1) LU85292A1 (en)
NL (1) NL8401074A (en)
NO (1) NO157099C (en)
NZ (1) NZ207592A (en)
PH (1) PH20038A (en)
PL (1) PL141866B1 (en)
PT (1) PT78603B (en)
SE (1) SE453827B (en)
SU (1) SU1240351A3 (en)
YU (1) YU81784A (en)
ZA (1) ZA842223B (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2492372A1 (en) * 1980-10-21 1982-04-23 Cird 1,8-DIHYDROXY-9-ANTHRONES SUBSTITUTED IN POSITION 10 AND THEIR USE IN HUMAN OR VETERINARY MEDICINE AND IN COSMETICS
US4843097A (en) * 1984-06-13 1989-06-27 Groupement D'interet Economique Dit: Centre International De Recherches Dermatologiques C.I.R.D. 10-aryl-1,8-dihydroxy-9-anthrones and their esters, process for preparing same, and use of same in human and veterinary medicine and in cosmetics
FR2591222B1 (en) * 1985-12-11 1988-07-22 Cird MONO, DI AND TRI-ESTERS OF 1,8-DIHYDROXY PHENYL-10 ANTHRONE-9 OR ANTHRANOL-9, THEIR PREPARATION PROCESS AND THEIR USE IN HUMAN OR VETERINARY MEDICINE AND IN COSMETICS
FR2566772B1 (en) * 1984-06-29 1986-11-14 Cird DIACYLOXY-1,8 ACYL-10 ANTHRONES, THEIR PREPARATION PROCESS AND THEIR USE IN HUMAN OR VETERINARY MEDICINE AND IN COSMETICS
FR2580631B1 (en) * 1985-04-17 1987-05-29 Cird HYDROXY-1 ACYLOXY-8 ACYL-10 ANTHRONES, THEIR PREPARATION PROCESS AND THEIR USE IN HUMAN OR VETERINARY MEDICINE AND IN COSMETICS
AU660718B2 (en) * 1991-10-04 1995-07-06 Fisher & Paykel Healthcare Limited Improvements in or relating to humidifiers
DE4231636A1 (en) * 1992-09-22 1994-03-24 Beiersdorf Ag New anthrone and anthracene derivatives substituted in the 10-position, processes for their preparation, pharmaceutical or cosmetic compositions containing these compounds and their use
US5426197A (en) * 1993-07-19 1995-06-20 Teva Pharmaceutical Industries, Ltd. 10-substituted 1,8-dihydroxy-9(10H) anthracenone pharmaceuticals

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI57743C (en) * 1979-03-29 1980-10-10 Orion Yhtymae Oy FREQUENCY REQUIREMENT FOR NYA 1,8-DIHYDROXI-10-ACYL-9-ANTRONER MOT PSORIASIS

Also Published As

Publication number Publication date
IS2902A7 (en) 1984-06-07
GB8408666D0 (en) 1984-05-16
HUT36076A (en) 1985-08-28
ZA842223B (en) 1984-11-28
PL141866B1 (en) 1987-09-30
PH20038A (en) 1986-09-04
GB2140007B (en) 1986-04-09
PT78603A (en) 1984-06-01
NL8401074A (en) 1984-12-17
FI831739A0 (en) 1983-05-18
DE3418382A1 (en) 1984-11-22
GB2140007A (en) 1984-11-21
NZ207592A (en) 1986-11-12
ES531760A0 (en) 1985-05-16
IN156115B (en) 1985-05-18
CA1212943A (en) 1986-10-21
IT1173473B (en) 1987-06-24
PT78603B (en) 1986-06-26
CS291184A2 (en) 1987-08-13
SE453827B (en) 1988-03-07
SU1240351A3 (en) 1986-06-23
ES8505167A1 (en) 1985-05-16
JPS59212443A (en) 1984-12-01
DK173584A (en) 1984-11-19
BE899334A (en) 1984-07-31
IL71446A0 (en) 1984-07-31
YU81784A (en) 1986-10-31
FR2546162B1 (en) 1987-01-30
AU560079B2 (en) 1987-03-26
IL71446A (en) 1987-01-30
DD223702A5 (en) 1985-06-19
LU85292A1 (en) 1984-10-26
GR79971B (en) 1984-10-31
SE8402649L (en) 1984-11-19
DK154207B (en) 1988-10-24
FI66585B (en) 1984-07-31
CH659464A5 (en) 1987-01-30
NO157099C (en) 1988-01-20
NO841965L (en) 1984-11-19
PL247724A1 (en) 1985-06-18
AU2599884A (en) 1984-11-22
IT8420213A0 (en) 1984-03-23
SE8402649D0 (en) 1984-05-16
DK154207C (en) 1989-03-13
DK173584D0 (en) 1984-03-30
CS256379B2 (en) 1988-04-15
NO157099B (en) 1987-10-12
FI66585C (en) 1984-11-12
FR2546162A1 (en) 1984-11-23

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