KR840006626A - 케토화합물의 제조방법 - Google Patents

케토화합물의 제조방법 Download PDF

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Publication number
KR840006626A
KR840006626A KR1019830003504A KR830003504A KR840006626A KR 840006626 A KR840006626 A KR 840006626A KR 1019830003504 A KR1019830003504 A KR 1019830003504A KR 830003504 A KR830003504 A KR 830003504A KR 840006626 A KR840006626 A KR 840006626A
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KR
South Korea
Prior art keywords
propyl
oxodecahydroquinoline
solvent
optically active
trans
Prior art date
Application number
KR1019830003504A
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English (en)
Other versions
KR860001506B1 (ko
Inventor
메너트 샤우스 존 (외 1)
Original Assignee
아더 알. 웨일
일라이 릴리 앤드 캄파니
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by 아더 알. 웨일, 일라이 릴리 앤드 캄파니 filed Critical 아더 알. 웨일
Publication of KR840006626A publication Critical patent/KR840006626A/ko
Application granted granted Critical
Publication of KR860001506B1 publication Critical patent/KR860001506B1/ko

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

내용 없음.

Description

케토화합물의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (7)

  1. (a) 트랜스-dI-I/n-프로필-6-옥소데카하이드로퀴놀린 라세미체 용액을 적어도 0.5당량의 광학 적 활성 디-p-톨루오일타타르산을 함유하는 용액과 접촉 반응시키고; (b)생성된 광학적 활성 트랜스-1-n-프로필-6-옥소데카히이드로퀴놀린 이성체와 광학적 활성 dI-n-톨루오일타타르산과의 염을 분리 하며; (e) 생성된 염을 염기로 처리하고; (d) 이로부터 광학적 활성트랜스-1-n-프로필-6-옥소데카이드로퀴놀린 이성체를 분리하고; (e) 임의로는 이와같이 수득한 유지염기를 염으로 전환시킴을 특징으로 하여, 트랜스-dI-1-n-프로필-6-옥소데카하이드로퀴놀린으로부터 구조식(IIIa) 또는 (IIIb)의 광학적 이성체 및 그의 산부가염을 제조하는 방법.
  2. 제1항에 있어서 메탄올을 용매로 사용하는 방법.
  3. 제1항에 있어서 용매가 메탄을 /사세토니트릴 혼합물인 방법.
  4. 제1항에 있어서 용매가 메탄을/메틸이소부틸케톤 혼합물인 방법.
  5. 제1 또는 3항에 있어서 용매가 1:4 내지 1:10의 메탄올 : 아세토니트릴 용매 혼합물인 방법.
  6. 제1항에 있어서 4aR,8aR-I-n-프로필-6-옥소데카하이드로퀴놀린의 염이(-)-디-p-톨루오일 타타르산에 의해 생성된 방법.
  7. 제1항에 있어서 4aS, 8aS-1-n-프로필-6-옥소데카하이드로 퀴놀린의 염이(+)-디-p-톨루오일타타르산에 의해 생성된 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019830003504A 1982-11-03 1983-07-27 트랜스-dl-1-n-프로필-6-옥소데카하이드로 퀴놀린으로부터 그의 광학 이성체로의 분할방법 KR860001506B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US439107 1982-11-03
US06/439,107 US4471121A (en) 1982-11-03 1982-11-03 Method of resolving trans-d alpha-1-n-propyl-6-oxodecahydroquinoline and di-p-toluoyltartaric acid salts thereof

Publications (2)

Publication Number Publication Date
KR840006626A true KR840006626A (ko) 1984-12-01
KR860001506B1 KR860001506B1 (ko) 1986-09-30

Family

ID=23743321

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019830003504A KR860001506B1 (ko) 1982-11-03 1983-07-27 트랜스-dl-1-n-프로필-6-옥소데카하이드로 퀴놀린으로부터 그의 광학 이성체로의 분할방법

Country Status (22)

Country Link
US (1) US4471121A (ko)
EP (1) EP0112604A1 (ko)
JP (1) JPS5982365A (ko)
KR (1) KR860001506B1 (ko)
AU (1) AU557306B2 (ko)
CA (1) CA1198115A (ko)
CS (1) CS234050B2 (ko)
DD (1) DD210045A5 (ko)
DK (1) DK343183A (ko)
ES (1) ES8502092A1 (ko)
FI (1) FI832720A (ko)
GB (1) GB2129422B (ko)
GR (1) GR79600B (ko)
HU (1) HU189311B (ko)
IL (1) IL69360A (ko)
NZ (1) NZ205030A (ko)
PH (1) PH20193A (ko)
PL (1) PL243198A1 (ko)
PT (1) PT77113B (ko)
RO (1) RO86512B (ko)
SU (1) SU1282815A3 (ko)
ZA (1) ZA835502B (ko)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL73001A0 (en) * 1983-09-26 1984-12-31 Lilly Co Eli Improvements in and relating to 6-oxodecahydroquinolines
US4778894A (en) * 1983-09-26 1988-10-18 Eli Lilly And Company 6 oxo-decahydroquinolines
US4764609A (en) * 1986-03-31 1988-08-16 Eli Lilly And Company Synthesis of 2-aminopyrimido[4,5-g]quinolines
US4826986A (en) * 1986-06-16 1989-05-02 Eli Lilly And Company 6-Oxo-trans-octa- and decahydroquinolines
US4977160A (en) * 1986-06-16 1990-12-11 Eli Lilly And Company BCD tricyclic ergoline part-structure analogues
US5134143A (en) * 1986-06-16 1992-07-28 Eli Lilly And Company BCD tricyclic ergoline part-structure analogues
FR2600649B1 (fr) * 1986-06-26 1989-02-24 Rhone Poulenc Sante Procede de preparation du maleate acide de levomepromazine

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4230861A (en) * 1979-01-22 1980-10-28 Eli Lilly And Company 1-And/or 7-substituted-6-hydroxy (or oxo)-3-decahydroquinoline carboxylic acids
US4198415A (en) * 1979-01-22 1980-04-15 Eli Lilly And Company Prolactin inhibiting octahydro pyrazolo[3,4-g]quinolines

Also Published As

Publication number Publication date
FI832720A (fi) 1984-05-04
HU189311B (en) 1986-06-30
GB8320249D0 (en) 1983-09-01
GB2129422B (en) 1986-08-20
PH20193A (en) 1986-10-16
EP0112604A1 (en) 1984-07-04
DK343183D0 (da) 1983-07-27
AU1734083A (en) 1984-05-10
CA1198115A (en) 1985-12-17
AU557306B2 (en) 1986-12-18
RO86512B (ro) 1985-03-31
FI832720A0 (fi) 1983-07-27
ES524454A0 (es) 1984-12-16
US4471121A (en) 1984-09-11
SU1282815A3 (ru) 1987-01-07
GR79600B (ko) 1984-10-31
KR860001506B1 (ko) 1986-09-30
PL243198A1 (en) 1984-08-13
ES8502092A1 (es) 1984-12-16
CS234050B2 (en) 1985-03-14
NZ205030A (en) 1986-03-14
PT77113A (en) 1983-08-01
RO86512A (ro) 1985-03-15
PT77113B (en) 1986-04-11
JPS5982365A (ja) 1984-05-12
ZA835502B (en) 1985-03-27
GB2129422A (en) 1984-05-16
DK343183A (da) 1984-05-04
DD210045A5 (de) 1984-05-30
IL69360A (en) 1986-10-31

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