KR840006205A - 클로로 아세트 아미드류의 제조방법 - Google Patents
클로로 아세트 아미드류의 제조방법 Download PDFInfo
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- KR840006205A KR840006205A KR1019830004281A KR830004281A KR840006205A KR 840006205 A KR840006205 A KR 840006205A KR 1019830004281 A KR1019830004281 A KR 1019830004281A KR 830004281 A KR830004281 A KR 830004281A KR 840006205 A KR840006205 A KR 840006205A
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- alkyl
- substituted
- group
- unsubstituted
- cycloalkyl
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/50—Three nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/56—One oxygen atom and one sulfur atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/58—Two sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (1)
- 하기식(Ⅱ)의 화합물에서 N-히드록시아세틸기의 HO기를 Cl로 치환한뒤 하기식(Ⅲ)의 화합물을 하기식(Ⅳ)의 화합물로 N-알킬화하고 하기식(Ⅴ)의 화합물을 클로로아세틸클로라이드로 N-아실화하는 것으로 구성된 하기식(Ⅰ) 화합물이 제조방법.상기식에서, Ar은 치환되었거나 되지않은 5-피리미디닐 Y는 F, Cl 또는 Br로 부터 선택된 할로겐으로 치환되었거나 되지않은 C1-8알킬, C3-8알케닐, C3-8알키닐, C3-8시클로알킬, C5-8시클로알케닐, C3-8시클로알킬-C1-5알킬, CH(R1)-COY1(R1은 H 또는 C1-5알킬; Y1은 CO기와 함께 에스테르 또는 아미드기를 형성); R2-Az (R2는 C1-5알킬로 치환되었거나 치환되지 않은 CH2-CH3또는 CH2, Az는 그것의 질소원자중 1개에 의하여 R2에 연결된 디-또는 트리아졸 또는 고리내의 탄소원자 하나에 의해 R2에 연결된5-원소의 방향족 헤테로고리로 O,S 또는N으로 부터 선택된 1,2 또는 3개의 헤테로원자를 함유하거나 또는 피리미디닐기 또는 -O-R3인데, R3은 H 또는 치환되거나 치환되지 않은 C1-8알킬, C3-8, 알케닐,C3-8알키닐, C3-8시클로알킬, C5-8시클로알케닐, 또는 C3-8시클로알킬-C1-5알킬 또는 페닐; 또는인데R4는 C1-5알킬, C3-5알케닐, C3-5알키닐, C3-8시클로알킬 C5-8시클로알케닐, C3-8시클로 알킬-C1-5알킬로 부터 선택된 탄수화수소로서 본 탄화수소는 F,Cl 또는 Br로 부터 선택된 할로겐에 의하여 치환되거나 치환되지 않는다; 또는 알렌, R4`는 H 또는 R4로 정의되어진 것중의 1개, A는R3에 연결되어 헤테로원자로서 1 또는 2개의 산소로 구성된 포화된 산소를 함유하는 헤테로시클릭고리를 형성하는데 N과 O원자는 3의 탄소원자로 분리된다.또는는 상기 R4로 정의되어진 것중 1개 R4와 R5'는 독자적으로 H 또는 CH3또는 R5와 R5'는 함께 (CH2)3또는 (CH2)4를 형성, 또는 알렌 또는 CH2-CH=C=CH2또는R6는 H 또는 C1-3B는 N(CH3)COCH3또는 N-원자가 CHR6에 연결 5-원소의 락탐. L은 N-알킬화반응조건하에서 분리될 수 있는 이탈기.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB8226004 | 1982-09-13 | ||
GB8226004 | 1982-09-13 |
Publications (1)
Publication Number | Publication Date |
---|---|
KR840006205A true KR840006205A (ko) | 1984-11-22 |
Family
ID=10532865
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019830004281A KR840006205A (ko) | 1982-09-13 | 1983-09-12 | 클로로 아세트 아미드류의 제조방법 |
Country Status (21)
Country | Link |
---|---|
JP (1) | JPS601167A (ko) |
KR (1) | KR840006205A (ko) |
AT (1) | ATA324183A (ko) |
AU (1) | AU570413B2 (ko) |
BE (1) | BE897705A (ko) |
BR (1) | BR8304942A (ko) |
CH (1) | CH655717A5 (ko) |
DE (1) | DE3331873A1 (ko) |
DK (1) | DK413083A (ko) |
EG (1) | EG16726A (ko) |
ES (1) | ES525576A0 (ko) |
FR (1) | FR2532935B1 (ko) |
HU (1) | HU190852B (ko) |
IE (1) | IE56002B1 (ko) |
IL (1) | IL69692A (ko) |
IT (1) | IT1169813B (ko) |
NL (1) | NL8303127A (ko) |
PL (1) | PL142275B1 (ko) |
SU (1) | SU1272966A3 (ko) |
TR (1) | TR21905A (ko) |
ZA (1) | ZA836789B (ko) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4657579A (en) * | 1982-09-13 | 1987-04-14 | Sandoz Ltd. | Novel N-(5-pyrimidinyl)-chloroacetamides |
EP0175652A3 (de) * | 1984-09-20 | 1988-07-20 | Ciba-Geigy Ag | 5-Acylaminopyrimidine |
US4722927A (en) * | 1986-04-28 | 1988-02-02 | Warner-Lambert Company | Pyrimidine amides of oleic or linoleic acid, composition containing them and their use as inhibitors of acyl-CoA cholesterol acyltransferase |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH454878A (de) * | 1961-12-14 | 1968-04-30 | Ciba Geigy | Verfahren zur Herstellung von Diazinen |
-
1983
- 1983-09-01 CH CH4800/83A patent/CH655717A5/de not_active IP Right Cessation
- 1983-09-03 DE DE19833331873 patent/DE3331873A1/de not_active Withdrawn
- 1983-09-08 BE BE1/10862A patent/BE897705A/fr not_active IP Right Cessation
- 1983-09-08 FR FR8314442A patent/FR2532935B1/fr not_active Expired
- 1983-09-09 NL NL8303127A patent/NL8303127A/nl not_active Application Discontinuation
- 1983-09-12 BR BR8304942A patent/BR8304942A/pt unknown
- 1983-09-12 AU AU19033/83A patent/AU570413B2/en not_active Ceased
- 1983-09-12 PL PL1983243722A patent/PL142275B1/pl unknown
- 1983-09-12 AT AT0324183A patent/ATA324183A/de not_active Application Discontinuation
- 1983-09-12 JP JP58169093A patent/JPS601167A/ja active Pending
- 1983-09-12 DK DK413083A patent/DK413083A/da not_active Application Discontinuation
- 1983-09-12 IT IT22850/83A patent/IT1169813B/it active
- 1983-09-12 KR KR1019830004281A patent/KR840006205A/ko not_active Application Discontinuation
- 1983-09-12 IL IL69692A patent/IL69692A/xx unknown
- 1983-09-12 TR TR21905A patent/TR21905A/xx unknown
- 1983-09-12 IE IE2125/83A patent/IE56002B1/xx unknown
- 1983-09-12 HU HU833168A patent/HU190852B/hu unknown
- 1983-09-13 ZA ZA836789A patent/ZA836789B/xx unknown
- 1983-09-13 ES ES525576A patent/ES525576A0/es active Granted
- 1983-09-13 EG EG564/83A patent/EG16726A/xx active
-
1984
- 1984-09-11 SU SU843790652A patent/SU1272966A3/ru active
Also Published As
Publication number | Publication date |
---|---|
ES8600859A1 (es) | 1985-10-16 |
FR2532935A1 (fr) | 1984-03-16 |
DK413083A (da) | 1984-03-14 |
TR21905A (tr) | 1985-10-21 |
DK413083D0 (da) | 1983-09-12 |
IL69692A0 (en) | 1983-12-30 |
FR2532935B1 (fr) | 1986-08-29 |
NL8303127A (nl) | 1984-04-02 |
ZA836789B (en) | 1985-04-24 |
AU1903383A (en) | 1984-03-22 |
ES525576A0 (es) | 1985-10-16 |
PL243722A1 (en) | 1984-12-17 |
AU570413B2 (en) | 1988-03-17 |
HU190852B (en) | 1986-11-28 |
BR8304942A (pt) | 1984-04-24 |
BE897705A (fr) | 1984-03-08 |
IT8322850A0 (it) | 1983-09-12 |
ATA324183A (de) | 1990-03-15 |
IE56002B1 (en) | 1991-03-13 |
CH655717A5 (de) | 1986-05-15 |
IL69692A (en) | 1986-10-31 |
DE3331873A1 (de) | 1984-03-15 |
JPS601167A (ja) | 1985-01-07 |
EG16726A (en) | 1990-03-30 |
IE832125L (en) | 1984-03-13 |
IT1169813B (it) | 1987-06-03 |
PL142275B1 (en) | 1987-10-31 |
SU1272966A3 (ru) | 1986-11-23 |
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