KR830005114A - Lrf 길항 물질 제조방법 - Google Patents

Lrf 길항 물질 제조방법 Download PDF

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Publication number
KR830005114A
KR830005114A KR1019810001129A KR810001129A KR830005114A KR 830005114 A KR830005114 A KR 830005114A KR 1019810001129 A KR1019810001129 A KR 1019810001129A KR 810001129 A KR810001129 A KR 810001129A KR 830005114 A KR830005114 A KR 830005114A
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KR
South Korea
Prior art keywords
phe
gly
trp
pro
protecting group
Prior art date
Application number
KR1019810001129A
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English (en)
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KR850001159B1 (ko
Inventor
로오라 리비어 캐서린
에드워어드 프레드릭 리비어 지인
워어커 베일 쥬니어 윌리
Original Assignee
델버어트 어어니스트 그란쯔
더 솔크 인스티튜트 훠 바이올로지칼 스터디이즈
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Priority claimed from US06/140,487 external-priority patent/US4292313A/en
Priority claimed from US06/147,555 external-priority patent/US4307083A/en
Application filed by 델버어트 어어니스트 그란쯔, 더 솔크 인스티튜트 훠 바이올로지칼 스터디이즈 filed Critical 델버어트 어어니스트 그란쯔
Publication of KR830005114A publication Critical patent/KR830005114A/ko
Application granted granted Critical
Publication of KR850001159B1 publication Critical patent/KR850001159B1/ko

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/16—Oxytocins; Vasopressins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/13—Luteinizing hormone-releasing hormone; related peptides

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Endocrinology (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

내용 없음

Description

LRF 길항 물질 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (1)

  1. (가) 다음의 구조식을 가지는 중간 화합물을 제조하여
    X1-R1-R2-R3-Ser(X2)-Tyr-(X3)-R4-R5-Arg(X4)-Pro-X5
    단, 위의식에서
    X1: α-아미노 보호기
    X2: Ser의 알코올성 히드록시기의 보호기
    X3: Tyr의 페놀성 히드록시기의 보호기
    X4: Arg의 질소원자의 보호기
    X5: Gly-O-HC2[수지 지지체], O-CH2-[수지지지체], Gly-NH-[수지지지체], Gly-NH3또는 NHCH2CH3
    (나) X1에서부터 X5까지의 여러기중에서 한가지 이상을 분할하고 필요에 따라서는 생성된 펩티드를 무독성 염으로 전환시킴을 특징으로 하는 다음과 같은 구조식을 가진 화합물 제조방법.
    X-R1-R2-R3-Ser-Tyr-R4-R5-Arg-Pro-R6
    단, 위의식에서
    X : 수소 또는 탄소원자수가 7이하인 아실기
    R1: 디히드로(dehydro) Pro, 디히드로(dehydro) D-Pro, Thz 또는 D-Thz,
    R2: D-Phe, D-His, D-Trp, Trp, Cl-D-Phe, 디클로로-D-Phe, CF3-D-Phe, F-D-Phe, 디클루오로-D-Phe, ACNH-D-Phe, NO2-D-Phe, 디니트로-D-Phe, Br-D-Phe, 디브로모-D-Phe, CH3S-D-Phe, OCH3-D-Phe 또는 CH3-D-Phe,
    R3: D-Trp, Trp, D-Phe 또는 D-HiS,
    R4: Gly 또는 D-이성질체아미노산,
    R5: Leu 또는 NaMe-Leu,
    R6: Gly-NH2또는 NHCH2CH3
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019810001129A 1980-04-15 1981-04-04 펩타이드의 제조방법 KR850001159B1 (ko)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US140487 1980-04-15
US140.487 1980-04-15
US06/140,487 US4292313A (en) 1980-04-15 1980-04-15 LRF Antagonists
US147.555 1980-05-08
US06/147,555 US4307083A (en) 1978-10-16 1980-05-08 LRF Antagonists
US147555 1980-05-08
US18259480A 1980-08-29 1980-08-29
US182594 1980-08-29
US182.594 1980-08-29

Publications (2)

Publication Number Publication Date
KR830005114A true KR830005114A (ko) 1983-07-23
KR850001159B1 KR850001159B1 (ko) 1985-08-16

Family

ID=27385503

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019810001129A KR850001159B1 (ko) 1980-04-15 1981-04-04 펩타이드의 제조방법

Country Status (12)

Country Link
EP (1) EP0038135B1 (ko)
KR (1) KR850001159B1 (ko)
AU (1) AU543921B2 (ko)
DD (1) DD160534A5 (ko)
DE (1) DE3164661D1 (ko)
DK (1) DK150206C (ko)
ES (1) ES501321A0 (ko)
GR (1) GR74501B (ko)
IE (1) IE51068B1 (ko)
IL (1) IL62449A (ko)
NZ (1) NZ196558A (ko)
YU (1) YU98981A (ko)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4409208A (en) * 1980-04-15 1983-10-11 The Salk Institute For Biological Studies GnRH antagonists
IL70888A0 (en) * 1983-03-10 1984-05-31 Salk Inst For Biological Studi Gn rh antagonist peptides and pharmaceutical compositions containing them
US4547370A (en) * 1983-11-29 1985-10-15 The Salk Institute For Biological Studies GnRH Antagonists
IL74827A (en) * 1984-05-21 1989-06-30 Salk Inst For Biological Studi Peptides active as gnrh antagonists and pharmaceutical compositions containing them
ZA862570B (en) * 1985-04-09 1986-12-30 Univ Tulane Therapeutic decapeptides
US4866160A (en) * 1985-04-09 1989-09-12 The Administrators Of The Tulane Educational Fund Therapeutic decapeptides
US5084443A (en) * 1989-12-04 1992-01-28 Biomeasure, Inc. Promoting expression of acetylcholine receptors with lhrh antagonist

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1532211A (en) * 1974-10-25 1978-11-15 Wellcome Found Lh-rh peptide analogues
US4087416A (en) * 1976-11-05 1978-05-02 Parke, Davis & Company New heptapeptides and methods for their production
NZ188987A (en) * 1977-11-30 1982-02-23 Salk Inst For Biological Studi Peptide analogues of luteinizing hormone releasing factor

Also Published As

Publication number Publication date
DE3164661D1 (de) 1984-08-16
IE51068B1 (en) 1986-09-17
DK166581A (da) 1981-10-16
IL62449A0 (en) 1981-05-20
YU98981A (en) 1984-04-30
NZ196558A (en) 1984-10-19
EP0038135B1 (en) 1984-07-11
DK150206B (da) 1987-01-05
IL62449A (en) 1984-03-30
AU6881481A (en) 1981-10-22
DK150206C (da) 1987-07-06
ES8207510A1 (es) 1982-09-16
EP0038135A2 (en) 1981-10-21
DD160534A5 (de) 1983-09-07
KR850001159B1 (ko) 1985-08-16
AU543921B2 (en) 1985-05-09
GR74501B (ko) 1984-06-28
IE810703L (en) 1981-10-15
EP0038135A3 (en) 1982-01-06
ES501321A0 (es) 1982-09-16

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