KR830005114A - Lrf 길항 물질 제조방법 - Google Patents
Lrf 길항 물질 제조방법 Download PDFInfo
- Publication number
- KR830005114A KR830005114A KR1019810001129A KR810001129A KR830005114A KR 830005114 A KR830005114 A KR 830005114A KR 1019810001129 A KR1019810001129 A KR 1019810001129A KR 810001129 A KR810001129 A KR 810001129A KR 830005114 A KR830005114 A KR 830005114A
- Authority
- KR
- South Korea
- Prior art keywords
- phe
- gly
- trp
- pro
- protecting group
- Prior art date
Links
- 239000002474 gonadorelin antagonist Substances 0.000 title 1
- 125000006239 protecting group Chemical group 0.000 claims 3
- 239000011347 resin Substances 0.000 claims 3
- 229920005989 resin Polymers 0.000 claims 3
- COLNVLDHVKWLRT-MRVPVSSYSA-N D-phenylalanine Chemical compound OC(=O)[C@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-MRVPVSSYSA-N 0.000 claims 2
- QIVBCDIJIAJPQS-SECBINFHSA-N D-tryptophane Chemical compound C1=CC=C2C(C[C@@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-SECBINFHSA-N 0.000 claims 2
- 125000000510 L-tryptophano group Chemical group [H]C1=C([H])C([H])=C2N([H])C([H])=C(C([H])([H])[C@@]([H])(C(O[H])=O)N([H])[*])C2=C1[H] 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- ONIBWKKTOPOVIA-SCSAIBSYSA-N D-Proline Chemical compound OC(=O)[C@H]1CCCN1 ONIBWKKTOPOVIA-SCSAIBSYSA-N 0.000 claims 1
- HNDVDQJCIGZPNO-RXMQYKEDSA-N D-histidine Chemical compound OC(=O)[C@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-RXMQYKEDSA-N 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 125000002252 acyl group Chemical group 0.000 claims 1
- 230000001476 alcoholic effect Effects 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 231100000252 nontoxic Toxicity 0.000 claims 1
- 230000003000 nontoxic effect Effects 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/16—Oxytocins; Vasopressins; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/13—Luteinizing hormone-releasing hormone; related peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Endocrinology (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Urology & Nephrology (AREA)
- Reproductive Health (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (1)
- (가) 다음의 구조식을 가지는 중간 화합물을 제조하여X1-R1-R2-R3-Ser(X2)-Tyr-(X3)-R4-R5-Arg(X4)-Pro-X5단, 위의식에서X1: α-아미노 보호기X2: Ser의 알코올성 히드록시기의 보호기X3: Tyr의 페놀성 히드록시기의 보호기X4: Arg의 질소원자의 보호기X5: Gly-O-HC2[수지 지지체], O-CH2-[수지지지체], Gly-NH-[수지지지체], Gly-NH3또는 NHCH2CH3(나) X1에서부터 X5까지의 여러기중에서 한가지 이상을 분할하고 필요에 따라서는 생성된 펩티드를 무독성 염으로 전환시킴을 특징으로 하는 다음과 같은 구조식을 가진 화합물 제조방법.X-R1-R2-R3-Ser-Tyr-R4-R5-Arg-Pro-R6단, 위의식에서X : 수소 또는 탄소원자수가 7이하인 아실기R1: 디히드로(dehydro) Pro, 디히드로(dehydro) D-Pro, Thz 또는 D-Thz,R2: D-Phe, D-His, D-Trp, Trp, Cl-D-Phe, 디클로로-D-Phe, CF3-D-Phe, F-D-Phe, 디클루오로-D-Phe, ACNH-D-Phe, NO2-D-Phe, 디니트로-D-Phe, Br-D-Phe, 디브로모-D-Phe, CH3S-D-Phe, OCH3-D-Phe 또는 CH3-D-Phe,R3: D-Trp, Trp, D-Phe 또는 D-HiS,R4: Gly 또는 D-이성질체아미노산,R5: Leu 또는 NaMe-Leu,R6: Gly-NH2또는 NHCH2CH3※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US140487 | 1980-04-15 | ||
US140.487 | 1980-04-15 | ||
US06/140,487 US4292313A (en) | 1980-04-15 | 1980-04-15 | LRF Antagonists |
US147.555 | 1980-05-08 | ||
US06/147,555 US4307083A (en) | 1978-10-16 | 1980-05-08 | LRF Antagonists |
US147555 | 1980-05-08 | ||
US18259480A | 1980-08-29 | 1980-08-29 | |
US182594 | 1980-08-29 | ||
US182.594 | 1980-08-29 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR830005114A true KR830005114A (ko) | 1983-07-23 |
KR850001159B1 KR850001159B1 (ko) | 1985-08-16 |
Family
ID=27385503
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019810001129A KR850001159B1 (ko) | 1980-04-15 | 1981-04-04 | 펩타이드의 제조방법 |
Country Status (12)
Country | Link |
---|---|
EP (1) | EP0038135B1 (ko) |
KR (1) | KR850001159B1 (ko) |
AU (1) | AU543921B2 (ko) |
DD (1) | DD160534A5 (ko) |
DE (1) | DE3164661D1 (ko) |
DK (1) | DK150206C (ko) |
ES (1) | ES501321A0 (ko) |
GR (1) | GR74501B (ko) |
IE (1) | IE51068B1 (ko) |
IL (1) | IL62449A (ko) |
NZ (1) | NZ196558A (ko) |
YU (1) | YU98981A (ko) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4409208A (en) * | 1980-04-15 | 1983-10-11 | The Salk Institute For Biological Studies | GnRH antagonists |
IL70888A0 (en) * | 1983-03-10 | 1984-05-31 | Salk Inst For Biological Studi | Gn rh antagonist peptides and pharmaceutical compositions containing them |
US4547370A (en) * | 1983-11-29 | 1985-10-15 | The Salk Institute For Biological Studies | GnRH Antagonists |
IL74827A (en) * | 1984-05-21 | 1989-06-30 | Salk Inst For Biological Studi | Peptides active as gnrh antagonists and pharmaceutical compositions containing them |
ZA862570B (en) * | 1985-04-09 | 1986-12-30 | Univ Tulane | Therapeutic decapeptides |
US4866160A (en) * | 1985-04-09 | 1989-09-12 | The Administrators Of The Tulane Educational Fund | Therapeutic decapeptides |
US5084443A (en) * | 1989-12-04 | 1992-01-28 | Biomeasure, Inc. | Promoting expression of acetylcholine receptors with lhrh antagonist |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1532211A (en) * | 1974-10-25 | 1978-11-15 | Wellcome Found | Lh-rh peptide analogues |
US4087416A (en) * | 1976-11-05 | 1978-05-02 | Parke, Davis & Company | New heptapeptides and methods for their production |
NZ188987A (en) * | 1977-11-30 | 1982-02-23 | Salk Inst For Biological Studi | Peptide analogues of luteinizing hormone releasing factor |
-
1981
- 1981-03-18 NZ NZ196558A patent/NZ196558A/xx unknown
- 1981-03-20 IL IL62449A patent/IL62449A/xx unknown
- 1981-03-26 AU AU68814/81A patent/AU543921B2/en not_active Ceased
- 1981-03-27 EP EP81301357A patent/EP0038135B1/en not_active Expired
- 1981-03-27 IE IE703/81A patent/IE51068B1/en unknown
- 1981-03-27 DE DE8181301357T patent/DE3164661D1/de not_active Expired
- 1981-04-04 KR KR1019810001129A patent/KR850001159B1/ko active
- 1981-04-13 GR GR64669A patent/GR74501B/el unknown
- 1981-04-13 DK DK166581A patent/DK150206C/da not_active IP Right Cessation
- 1981-04-14 ES ES501321A patent/ES501321A0/es active Granted
- 1981-04-15 DD DD81229265A patent/DD160534A5/de unknown
- 1981-04-15 YU YU00989/81A patent/YU98981A/xx unknown
Also Published As
Publication number | Publication date |
---|---|
DE3164661D1 (de) | 1984-08-16 |
IE51068B1 (en) | 1986-09-17 |
DK166581A (da) | 1981-10-16 |
IL62449A0 (en) | 1981-05-20 |
YU98981A (en) | 1984-04-30 |
NZ196558A (en) | 1984-10-19 |
EP0038135B1 (en) | 1984-07-11 |
DK150206B (da) | 1987-01-05 |
IL62449A (en) | 1984-03-30 |
AU6881481A (en) | 1981-10-22 |
DK150206C (da) | 1987-07-06 |
ES8207510A1 (es) | 1982-09-16 |
EP0038135A2 (en) | 1981-10-21 |
DD160534A5 (de) | 1983-09-07 |
KR850001159B1 (ko) | 1985-08-16 |
AU543921B2 (en) | 1985-05-09 |
GR74501B (ko) | 1984-06-28 |
IE810703L (en) | 1981-10-15 |
EP0038135A3 (en) | 1982-01-06 |
ES501321A0 (es) | 1982-09-16 |
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