KR830002799A - 신규한 복소환식 안트라싸이클린 화합물의 제조방법 - Google Patents
신규한 복소환식 안트라싸이클린 화합물의 제조방법 Download PDFInfo
- Publication number
- KR830002799A KR830002799A KR1019800001362A KR800001362A KR830002799A KR 830002799 A KR830002799 A KR 830002799A KR 1019800001362 A KR1019800001362 A KR 1019800001362A KR 800001362 A KR800001362 A KR 800001362A KR 830002799 A KR830002799 A KR 830002799A
- Authority
- KR
- South Korea
- Prior art keywords
- sulfur
- novel heterocyclic
- preparing novel
- structural formula
- anthracycline compound
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H9/00—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
- C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D333/64—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/74—Naphthothiophenes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (7)
- 다음 구조식 (X II)인 시스-디올의 클로로포름용액을 시안화수은, 브롬화수은 및 3A분자체로 처리하고 4-0-p-니트로벤조일-3-N-트리플루오로 아세틸다우노스 이미닐클로라이드로 처리하여 다음 구조식(XI V)인 보호된 배상체를 얻은 다음 0.1N-NaOH로 처리한 후 염산으로 처리하여 다음구조식(I)의 화합물을 제조하는 방법.
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- 상기 식에서 R은 수소 또는 하이드록시이고, X,Y 또는 Z는 황일 수 있는데, 다만 X가 황일 때는 Y와 Z는 모두 CH이고 Y가 황일때 X와 Z는 모두 CH이고 Z가 황일때 X와 Y는 모두 CH이다.
- ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/026,392 US4259476A (en) | 1979-04-02 | 1979-04-02 | Novel heterocyclic anthracycline compounds |
| US26392 | 1979-04-02 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR830002799A true KR830002799A (ko) | 1983-05-30 |
| KR840000009B1 KR840000009B1 (ko) | 1984-01-25 |
Family
ID=21831579
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019800001362A KR840000009B1 (ko) | 1979-04-02 | 1980-04-01 | 신규한 복소환식 안트라싸이클린 화합물의 제조방법 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US4259476A (ko) |
| EP (1) | EP0017469A1 (ko) |
| JP (1) | JPS56500299A (ko) |
| KR (1) | KR840000009B1 (ko) |
| AU (1) | AU5602080A (ko) |
| WO (1) | WO1980002112A1 (ko) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4585760A (en) * | 1981-07-16 | 1986-04-29 | American Cyanamid Company | Dimethylfurano heterocyclic analogs of daunomycin |
| JPS5815995A (ja) * | 1981-07-22 | 1983-01-29 | Kyowa Hakko Kogyo Co Ltd | Ｄｃ−４５−ａ↓１およびｄｃ−４５−ａ↓２ならびにそれらの製造法 |
| IT1215287B (it) * | 1985-07-09 | 1990-01-31 | Consiglio Nazionale Ricerche | Processo per la produzione di para-chinoni. |
| CN108017625B (zh) * | 2017-11-23 | 2019-05-21 | 浙江大学 | 萘并噻吩二酮类化合物及其制备方法和应用 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4020270A (en) * | 1974-05-02 | 1977-04-26 | Societa' Farmaceutici Italia S.P.A. | L-lyxohex-1-enopyranose derivative |
| GB1500421A (en) * | 1975-01-22 | 1978-02-08 | Farmaceutici Italia | Optically active anthracyclinones |
| US4039663A (en) * | 1975-03-19 | 1977-08-02 | Societa' Farmaceutici Italia S.P.A. | Daunomycins, process for their uses and intermediates |
| GB1511559A (en) * | 1975-09-26 | 1978-05-24 | Farmaceutici Italia | Anthracycline glycosides |
-
1979
- 1979-04-02 US US06/026,392 patent/US4259476A/en not_active Expired - Lifetime
-
1980
- 1980-02-29 AU AU56020/80A patent/AU5602080A/en not_active Abandoned
- 1980-03-25 JP JP50082280A patent/JPS56500299A/ja active Pending
- 1980-03-25 WO PCT/US1980/000312 patent/WO1980002112A1/en unknown
- 1980-04-01 EP EP80301033A patent/EP0017469A1/en not_active Ceased
- 1980-04-01 KR KR1019800001362A patent/KR840000009B1/ko active
Also Published As
| Publication number | Publication date |
|---|---|
| WO1980002112A1 (en) | 1980-10-16 |
| AU5602080A (en) | 1980-10-09 |
| JPS56500299A (ko) | 1981-03-12 |
| US4259476A (en) | 1981-03-31 |
| EP0017469A1 (en) | 1980-10-15 |
| KR840000009B1 (ko) | 1984-01-25 |
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