KR20230052800A - Health functional food composition for improvement of bowel function and relief of contipation comprising psyllium husk and complex extract, and manufacturing method thereof - Google Patents
Health functional food composition for improvement of bowel function and relief of contipation comprising psyllium husk and complex extract, and manufacturing method thereof Download PDFInfo
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Classifications
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- A—HUMAN NECESSITIES
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- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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- A23L3/00—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs
- A23L3/36—Freezing; Subsequent thawing; Cooling
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- A—HUMAN NECESSITIES
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- A23V2200/00—Function of food ingredients
- A23V2200/30—Foods, ingredients or supplements having a functional effect on health
- A23V2200/32—Foods, ingredients or supplements having a functional effect on health having an effect on the health of the digestive tract
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2250/00—Food ingredients
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- A23V2250/202—Algae extracts
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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- A23V2250/00—Food ingredients
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- A23V2250/21—Plant extracts
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- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
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- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
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- A—HUMAN NECESSITIES
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Abstract
Description
본 발명은 차전자피 및 복합추출물을 포함하는 장 기능 개선 및 배변 촉진용 건강기능식품 조성물 및 이의 제조방법에 관한 것이다.The present invention relates to a health functional food composition for improving bowel function and promoting defecation, including psyllium husks and complex extracts, and a method for preparing the same.
현대인들은 길어진 노동시간, 발달된 교통수단, 생활수준의 향상 등으로 인해 신체활동량은 낮아진 반면, 식생활은 서구화 및 인스턴트화되어 열량의 섭취가 늘어나고 섬유소의 섭취는 줄어들고 있다. 이로 인해 종래 서양에서 많이 발생하던 대사성 질환이 국내에서도 점차 증가하고 있으며, 특히, 임상에서도 잘 알려져 있는 변비를 가진 사람이 많아지고 있다.Modern people's physical activity has decreased due to longer working hours, developed means of transportation, and improved living standards, while their dietary life has become westernized and instantized, increasing their calorie intake and decreasing their fiber intake. Due to this, metabolic diseases that have occurred frequently in the West are gradually increasing in Korea, and in particular, people with constipation, which are well known clinically, are increasing.
일반적으로 음식 섭취 후 12-72시간 후 음식에서 영양성분이 빠진 찌꺼기가 외부로 배설되는 것이 정상적인 상태이다. 그러나, 어떠한 이유로 인해 인체 외부로 배출되지 못하고, 장내에 오랫동안 머물러 있게 되는 경우가 있는데 이를 변비라고 한다.In general, it is a normal state that wastes missing nutrients from food are excreted 12-72 hours after eating. However, for some reason, it cannot be discharged to the outside of the human body and stays in the intestine for a long time, which is called constipation.
변비는 질병이라기보다는 증상에 가까우며, 여러 증상과 병들로 나타난다. 가장 일반적인 증상으로는 배변 횟수의 감소(예를 들면, 1주일에 3회 미만), 불규칙적인 배변, 고통스럽고 힘겨운 배변, 딱딱하고 마른 배변, 잔변감과 비정상적으로 적은 양의 배변(예를 들면, 하루 50 g 이하)등이 일반적이다. Constipation is more like a symptom than a disease, and it appears as a variety of symptoms and diseases. The most common symptoms are decreased frequency of bowel movements (e.g. less than 3 times per week), irregular bowel movements, painful or difficult bowel movements, hard or dry bowel movements, feeling of residual stool and abnormally small amounts of stool (e.g. per day). 50 g or less), etc. are common.
의학적으로 변비는 배변 횟수가 적거나 배변이 힘든 경우를 강조하여 배변이 3-4일에 한번 미만인 경우로 정의하고 있으며, 남자보다는 여자, 젊은 사람 보다는 나이든 환자들에게서 변비가 더 흔하다고 알려져 있다.Medically, constipation is defined as a case in which defecation is less than once every 3-4 days, emphasizing the case of low or difficult defecation, and it is known that constipation is more common in women than men and in older patients than young people.
변비는 장폐색 또는 유동 방해, 항문과 골반의 이상, 신경성 질환, 대사성 또는 호르몬계의 이상으로부터 유래되거나, 약물 부작용으로부터, 그리고 탈수 또는 고정(immobilization)으로부터 유래할 수 있다. 변비는 특정 이유가 없이 발생할 수 있으며(만성 변비), 운동 부족, 배변 활동 무시, 낮은 섬유 섭취, 불규칙한 생활습관(예를 들면, 장거리 여행이나 병원 입원) 또는 개인적 요소로부터도 발생할 수 있다(Bosaeus, 2004).Constipation can result from intestinal obstruction or obstruction of flow, anorectal and pelvic disorders, neurological disorders, metabolic or hormonal disorders, drug side effects, and dehydration or immobilization. Constipation can occur for no specific reason (chronic constipation), lack of exercise, neglect of bowel movements, low fiber intake, irregular lifestyle (e.g., long-distance travel or hospitalization), or personal factors (Bosaeus, 2004).
종래 변비의 개선 또는 치료를 위해 다양한 배변 촉진 의약품, 기능성 식품 등이 사용되고 있으나, 그 효과가 미미하거나 일시적인 경우가 대부분이므로, 변비를 근본적으로 치료할 수 있다고 보기 어렵다.Conventionally, various defecation-promoting drugs, functional foods, etc. are used to improve or treat constipation, but in most cases, the effect is insignificant or temporary, so it is difficult to see that constipation can be fundamentally treated.
따라서, 인체에 무해한 천연물 재료를 이용한 장 기능 개선 및 배변 촉진용 기능성 식품 조성물의 개발이 필요하다.Therefore, it is necessary to develop a functional food composition for improving bowel function and promoting defecation using natural materials harmless to the human body.
본 발명자들은 상기 종래 기술의 문제점을 인지하고, 특정 추출물을 포함하는 건강기능식품 조성물이 복용 시 배변빈도, 배변경도, 배변통증, 가스발생, 잔변감, 복부팽만 등 장 기능 및 배변과 관련된 현상들을 개선시키는 효과를 나타내어 장 기능 개선 및 배변 촉진 용도로 유용하게 사용될 수 있다는 점을 입증하고 본 발명을 완성하기에 이르렀다.The present inventors have recognized the problems of the prior art, and when a health functional food composition containing a specific extract is taken, bowel function and bowel movement-related phenomena such as bowel movement frequency, bowel change degree, bowel pain, gas generation, residual stool sensation, and abdominal distension, By demonstrating the effect of improving bowel function and proving that it can be usefully used for promoting bowel movements, the present invention has been completed.
본 발명은 차전자피; 및 다시마, 어성초, 퉁퉁마디, 산수유, 감초 및 길경의 복합추출물;을 포함하는 장 기능 개선 및 배변 촉진용 식품 조성물에 관한 것이다.The present invention is psyllium husk; It relates to a food composition for improving bowel function and promoting defecation, including; and complex extracts of kelp, eoseongcho, tungtungmadi, cornus oil, licorice, and cilantro.
본 발명은 상기 장 기능 개선 및 배변 촉진용 건강기능식품 조성물을 제조하는 방법에 관한 것이다.The present invention relates to a method for preparing a health functional food composition for improving intestinal function and promoting bowel movement.
이하 이를 구체적으로 설명한다. 본 발명에서 개시된 다양한 요소들의 모든 조합은 본 발명의 범주에 속한다. 또한, 하기의 구체적인 서술에 의해 본 발명 범주가 제한된다고 볼 수 없다.Hereinafter, this will be described in detail. All combinations of the various elements disclosed herein fall within the scope of the present invention. In addition, it cannot be seen that the scope of the present invention is limited by the specific description below.
본 발명은 차전자피; 및 다시마, 어성초, 퉁퉁마디, 산수유, 감초 및 길경의 복합추출물;을 포함하는 장 기능 개선 및 배변 촉진용 식품 조성물을 제공한다.The present invention is psyllium husk; It provides a food composition for improving bowel function and promoting bowel movement, including; and complex extracts of kelp, eoseongcho, tungtungmadi, cornus oil, licorice, and gilgyeong.
본 발명에서 "차전자피(Psyllium husk)"는 질경이과(Plantaginaceae)에 속하는 다년생 초본 질경이(Plantago asiatica)의 성숙한 종자인 차전자의 껍질을 당해 업계에 널리 공지된 추출, 분리, 정제방법에 의해 수득한 것 또는 시판되는 분말형태의 시약을 말한다. 차전자(Psyllium)는 전세계 생산량의 약 80 %를 차지하는 인도가 주산지이며, 1,000 개 차전자의 무게가 2 g 보다 작은 차전자 씨앗의 껍질을 차전자피라고 한다. 한방에서 차전자는 강력한 이뇨제로 신장염, 방광염 및 요도염 등에 널리 사용되어 왔으며, 무기질, 단백질, 비타민류 및 다당류 등이 많이 함유되어 있어, 상기 차전자에 포함된 성분들은 항염증 작용에 관여하는 것으로 알려져 있다.In the present invention, "Psyllium husk" is obtained from the husk of psyllium, a mature seed of Plantago asiatica, a perennial herb belonging to the Plantaginaceae, by extraction, separation, and purification methods well known in the art. or a reagent in the form of a commercially available powder. Psyllium is the main producer in India, which accounts for about 80% of world production, and the shell of psyllium seeds weighing less than 2 g of 1,000 psyllium is called psyllium husk. In oriental medicine, psyllium has been widely used in nephritis, cystitis, and urethritis as a powerful diuretic, and contains a lot of minerals, proteins, vitamins, and polysaccharides, and the components included in psyllium are known to be involved in anti-inflammatory action. there is.
본 발명에서 "다시마(Laminaria japonica)"는 갈조강(Phaeophyceae) 참다시마, 해대 또는 해곤포라고도 지칭되는 다시마목(Laminariales) 다시마과(Laminariaceae)에 속하는 다년생 대형 갈조류를 의미한다. 외관상 엽상부, 줄기, 뿌리로 구분된다. 한대, 아한대의 연안에 분포하는 한행성 해조류로서, 대한민국에서는 동해안 북부, 원산 이북의 함경북도에서 자생하며, 동해안 남부와 남해완의 완도 등지에서 양식을 한다. 상기 다시마는 예로부터 우리나라를 비롯한 일본, 중국에서 식용 또는 약용으로 널리 사용되어 왔다.In the present invention, "Laminaria japonica" refers to a perennial large brown algae belonging to the Laminariales kelp family (Laminariaceae), also referred to as Phaeophyceae kelp, seaweed, or seaweed. It is divided into leaf, stem, and root in appearance. It is a cold planetary algae distributed in the cold and subarctic regions. In Korea, it grows wild in the northern part of the East Sea and North Hamgyong Province, north of Wonsan, and is cultivated in the southern part of the East Sea and Wando in the South Sea. The kelp has been widely used for food or medicine in Korea, Japan, and China since ancient times.
본 발명에서 "어성초(Houttuynia cortata)"는 옛날부터 물고기의 냄새가 나는 풀이라고 하여 어성초라고 명명되고 있다. 어성초는 피부질환에 효과가 좋고 바이러스에 대한 억제 효능이 있으며 항산화 효과가 우수하여 항염증 작용, 항 치매효과, 파킨슨에도 효과가 있는 것으로 알려져 있다. 또한 여드름 개선용 화장품으로도 개발되고 있다. 이러한 어성초에는 플라보노이드(Flavonoid) 성분을 풍부하게 함유하고 있다는 점이 보고되어 있다.In the present invention, "Houttuynia cortata" has been named Houttuynia cortata because it is a grass that smells of fish since ancient times. Houttuynia cordata is known to be effective in skin diseases, has an inhibitory effect on viruses, and has excellent antioxidant effects, so it is effective in anti-inflammatory, anti-dementia, and Parkinson's diseases. It is also being developed as a cosmetic for improving acne. It has been reported that these Eoseongchos are rich in flavonoids.
본 발명에서 "퉁퉁마디"는 명아주과에 속하는 1년생 초본 식물로서 염생식물 중 염저항성이 강하며, 생육을 위하여 염류를 절대적으로 필요로 하는 절대염생식물이다. 퉁퉁마디는 체내 다량의 식물성 염분 (NaCl, KCl 등)과 칼슘, 마그네슘, 칼륨 등을 함유하고 있으며, 다량의 식이섬유, 필수아미노산 등의 영양소와 클로로필, 폴리페놀, 플라보노이드의 식물 생리활성 물질도 풍부하여 몸 안에 쌓인 독소와 숙변을 없애고, 암, 고혈압, 당뇨병, 간염, 피부병, 관절염 등을 치료하기 위한 민간요법으로 활용되어 왔다.In the present invention, "tungtungmadi" is an annual herbaceous plant belonging to the Goat family, which has strong salt resistance among salt plants and is an absolute salt plant that absolutely requires salt for growth. It contains a large amount of vegetable salt (NaCl, KCl, etc.), calcium, magnesium, and potassium in the body, and is rich in nutrients such as a large amount of dietary fiber and essential amino acids, as well as plant physiologically active substances such as chlorophyll, polyphenols, and flavonoids. It has been used as a folk remedy to eliminate toxins and stools accumulated in the body, and to treat cancer, high blood pressure, diabetes, hepatitis, skin disease, and arthritis.
본 발명에서 "산수유(Cornus officinalis)"는 한국 및 기타 열대에서 온대 지역에 걸쳐 재배되는 층층나무과에 속하는 낙엽성 소교목을 의미하며, 다양한 변종, 아종을 포함한다. 산수유의 과육에는 부교감 신경을 흥분시키는 코르닌(cornin), 모로니사이드(Morroniside), 약간의 중추신경 흥분작용이 있는 로가닌(Loganin), 탄닌(tannin), 사포닌(Saponin) 등의 배당체와 수렴성분인 탄닌(tannin)과 비타민 A가 다량 함유되어 자양강정과 수렴작용에 효과가 있고, 암을 예방할 수 있는 셀레늄 등의 기능성분을 가지고 있으며, 그밖에 비타민 A와 다량의 당도 포함되어 있다.In the present invention, "Cornus officinalis" refers to a deciduous small tree belonging to the dogwood family cultivated throughout Korea and other tropical to temperate regions, and includes various varieties and subspecies. The flesh of Cornus officinalis contains glycosides such as cornin and Morroniside, which excite the parasympathetic nerves, and loganin, tannin, and saponin, which have a slight central nervous stimulation effect. It contains a large amount of tannin and vitamin A, which are astringent components, so it is effective for nourishment and astringent action, and has functional components such as selenium that can prevent cancer. In addition, it also contains vitamin A and a large amount of sugar.
본 발명에서 산수유는 과육, 잎, 줄기, 종자 및/또는 뿌리가 사용될 수 있으며, 본 발명의 실시예들에 따르면, 바람직하게는 열매를 사용할 수 있다.In the present invention, Cornus officinalis may use fruit flesh, leaves, stems, seeds and / or roots, and according to embodiments of the present invention, fruits may be preferably used.
본 발명에서 "감초(Licorice)"는 중국 북동부와 시베리아, 몽골, 중국 북부 등지에 분포하는 콩과에 속하는 여러해살이풀을 의미한다. 감초는 뿌리와 줄기 밑 부분을 감미제와 위궤양, 십이지장 궤양의 치료제로 사용할 수 있으며, 다른 약의 작용을 순하게 하므로, 한방에서 다양한 용도로 쓰이기도 한다. 일반적으로 감초는 글리시리진, 글라브릭산, 슈크로즈, 글루코즈, 리퀴리틴, 리코리시딘 등을 함유하고 있고, 글리시리진은 디프테리아 독소와 뱀독, 복어독 해독 효과가 있어 파상풍의 치료약으로 사용되기도 한다.In the present invention, "licorice" refers to a perennial plant belonging to the leguminous family distributed in northeastern China, Siberia, Mongolia, and northern China. Licorice root and lower part of the stem can be used as a sweetener and as a treatment for stomach ulcers and duodenal ulcers. In general, licorice contains glycyrrhizin, glavric acid, sucrose, glucose, liquiritin, licoricedin, etc., and glycyrrhizin has diphtheria toxin, snake venom, and blowfish poison detoxification effects, so it is also used as a treatment for tetanus.
본 발명에서 "길경(Platycodon root)"은 도라지로도 지칭되며, 초롱꽃과의 여러해살이풀로 산이나 들에서 흔히 자라고, 높이는 40 내지 100 센티미터이며, 뿌리가 굵으며 줄기는 하나로 나는 식물을 의미한다. 길경은 신경통과 편도 선염 등의 약재로 사용되어 왔으며, 거담, 진해, 진통, 진정, 해열 작용이 있어 소염진통, 진해거담제로도 사용되기도 한다.In the present invention, "Platycodon root" is also referred to as bellflower, and it is a perennial plant of the bellflower family that commonly grows in mountains or fields, has a height of 40 to 100 cm, has a thick root, and refers to a plant with a single stem. . Gilgyeong has been used as a medicine for neuralgia and tonsillitis, and is also used as an anti-inflammatory analgesic and antitussive expectorant because it has expectorant, antitussive, analgesic, sedative, and antipyretic effects.
본 발명에서 원재료로 사용된 차전자피, 다시마, 어성초, 퉁퉁마디, 산수유, 감초 및 길경은 자연에서 채취하거나 직접 재배한 것 또는 시판 중인 것(가공된 것을 포함)을 제한없이 사용할 수 있다.Psyllium husk, kelp, eoseongcho, tungtungmadi, cornus oil, licorice, and gilgyeong used as raw materials in the present invention can be used without limitation whether they are collected from nature, grown directly, or commercially available (including processed ones).
본 발명에서 "추출물"은 적절한 추출용매 및 추출방법을 사용하여 추출한 결과물을 의미하며, 상기 추출물은 추출로 인해 수득되는 추출액, 추출액의 희석액 또는 농축액, 추출액을 건조하여 얻어지는 건조물, 이들의 조정제물 또는 정제물, 또는 분획물을 포함한다.In the present invention, "extract" refers to a product extracted using an appropriate extraction solvent and extraction method, and the extract is an extract obtained by extraction, a diluted or concentrated solution of the extract, a dried product obtained by drying the extract, a crude product thereof, or Purified products or fractions are included.
본 발명에서 "복합추출물"은 각각의 추출물의 원재료를 동시에 혼합한 혼합물 상태에서 일정한 제조공정을 통해 추출한 추출물을 의미한다.In the present invention, "complex extract" refers to an extract extracted through a certain manufacturing process in a mixture state in which the raw materials of each extract are simultaneously mixed.
본 발명의 실시예들에 따르면, 상기 복합 추출물을 제조하기 위한 원재료는 다시마, 어성초, 퉁퉁마디, 산수유, 감초 및 길경이 분쇄되어 고르게 혼합되어 있는 상태일 수 있다.According to embodiments of the present invention, the raw material for preparing the composite extract may be in a state in which kelp, houttuynia cordata, tungtungmadi, cornus officinalis, licorice, and cilantro are pulverized and evenly mixed.
본 발명의 실시예들에 따르면, 상기 복합추출물은 다시마, 어성초, 퉁퉁마디, 산수유, 감초 및 길경을 1:1:1:1:1:1의 중량비로 혼합한 원재료 혼합물로부터 추출된 것일 수 있으며, 상기 중량비는 복합추출물의 활성성분에 의한 우수한 효과를 나타내기 위한 것일 수 있다.According to embodiments of the present invention, the composite extract may be extracted from a mixture of raw materials mixed with kelp, houttuynia cordata, cornelian cornus, licorice, and cilantro in a weight ratio of 1: 1: 1: 1: 1: 1, , The weight ratio may be to exhibit an excellent effect by the active ingredient of the composite extract.
본 발명의 실시예들에 따르면, 상기 건강기능식품 조성물은 상기 차전자피 및 복합추출물은 1:1의 중량비로 포함하는 것일 수 있으며, 상기 중량비는 건강기능식품 조성물의 활성성분에 의한 우수한 효과를 나타내기 위한 것일 수 있다.According to embodiments of the present invention, the health functional food composition may include the psyllium hull and the composite extract in a weight ratio of 1: 1, and the weight ratio exhibits excellent effects by the active ingredient of the health functional food composition may be for
본 발명에서 "활성성분"은 단독으로 목적하는 활성(효과)를 나타내거나 그 자체로서 활성이 없는 담체와 함께 활성을 나타낼 수 있는 성분을 의미하며, 본 명세서에서 유효성분과 상호교환적으로 사용될 수 있다.In the present invention, "active ingredient" means a component that can exhibit the desired activity (effect) alone or exhibit activity together with a carrier that is not active by itself, and can be used interchangeably with the active ingredient herein. .
본 발명의 건강기능식품 조성물에 포함되는 다시마, 어성초, 퉁퉁마디, 산수유, 감초 및 길경의 복합추출물은 특정한 제조방법으로 추출되어 혼합됨으로써 장 기능 개선 및 배변 촉진 효과가 증진된 것일 수 있다.The complex extracts of kelp, eoseongcho, tungtungmadi, cornus oil, licorice, and gilgyeong contained in the health functional food composition of the present invention may be extracted and mixed by a specific manufacturing method to improve intestinal function and promote bowel movement.
본 발명에서 복합추출물은 하기 단계를 포함하는 방법으로 추출된 것일 수 있다:In the present invention, the composite extract may be extracted by a method comprising the following steps:
S1) 다시마, 어성초, 퉁퉁마디, 산수유, 감초 및 길경의 원재료 혼합물을 분쇄하고, 상기 분쇄된 원재료 혼합물에 80%(w/v) 에탄올을 투입한 후, 교반하여 균질화하는 단계;S1) pulverizing a raw material mixture of kelp, eoseongcho, cornelian cornus, licorice, and gilgyeong, adding 80% (w / v) ethanol to the pulverized raw material mixture, and homogenizing by stirring;
S2) 상기 균질화된 원재료 혼합물 용액을 60 내지 80℃에서 2 내지 4시간 동안 초음파 처리하여 초음파추출하는 단계;S2) ultrasonically extracting the homogenized raw material mixture solution by ultrasonic treatment at 60 to 80 ° C. for 2 to 4 hours;
S3) 상기 초음파 처리된 용액을 여과하여 여과액 및 잔사물로 분리하는 단계;S3) filtering the sonicated solution to separate into a filtrate and a residue;
S4) 상기 분리된 잔사물에 정제수를 투입한 후, 교반하여 균질화하는 단계;S4) adding purified water to the separated residue and homogenizing it by stirring;
S5) 상기 균질화된 용액을 130 내지 150℃에서 2 내지 4시간 동안 열처리하여 열수추출하는 단계;S5) heat-treating the homogenized solution at 130 to 150° C. for 2 to 4 hours to perform hot water extraction;
S6) 상기 열처리된 용액을 여과하여 여과액 및 잔사물로 분리하는 단계; 및S6) separating the heat-treated solution into a filtrate and a residue by filtering; and
S7) 상기 S3 및 S6 단계에서 분리된 여과액을 혼합하는 단계.S7) mixing the filtrate separated in steps S3 and S6.
이하 복합추출물 제조방법의 각 단계를 구체적으로 설명한다.Hereinafter, each step of the composite extract manufacturing method will be described in detail.
본 발명의 복합추출물 제조방법에서 상기 S1 단계는 원재료 혼합물을 분쇄하고, 용매를 투입한 후, 교반 및 균질화하여 원재료 혼합물 용액을 제조하는 단계이다.In the composite extract manufacturing method of the present invention, the step S1 is a step of preparing a raw material mixture solution by pulverizing the raw material mixture, adding a solvent, and then stirring and homogenizing.
상기 S1 단계에서, 용매는 S1 단계에 이어 수행될 초음파 추출을 위해 80%(w/v) 에탄올인 것이 바람직하며, 정제수를 사용하는 경우, 추출하고자 하는 활성성분의 수율이 낮아질 수 있다.In step S1, the solvent is preferably 80% (w/v) ethanol for ultrasonic extraction to be performed following step S1, and when purified water is used, the yield of the active ingredient to be extracted may be lowered.
상기 S1 단계에서 원재료 혼합물은 동결 상태일 수 있다. 즉, 본 발명의 S1 단계에서는 원재료 혼합물은 동결된 상태에서 준비되어 분쇄기를 통해 분쇄되는 것일 수 있다.In the step S1, the raw material mixture may be in a frozen state. That is, in step S1 of the present invention, the raw material mixture may be prepared in a frozen state and then pulverized through a grinder.
상기 S1 단계의 분쇄는 10 내지 500 ㎛ 크기가 되도록 수행되는 것일 수 있으며, 바람직하게는 400 내지 500 ㎛ 크기가 되도록 수행되는 것일 수 있다.The grinding of step S1 may be performed to a size of 10 to 500 μm, preferably 400 to 500 μm.
상기 범위보다 작은 크기로 분쇄될 경우, 동결된 상태의 원재료 혼합물을 분쇄하는 과정에서 시간 및 에너지 효율이 저하될 수 있고, 상기 범위보다 크게 분쇄되는 경우 원재료 혼합물에 포함된 활성성분의 추출이 충분히 이루어지지 않아 본 발명에서 의도하고 있는 효과를 충분히 나타내지 못할 수 있다.When pulverized to a size smaller than the above range, time and energy efficiency may be reduced in the process of pulverizing the raw material mixture in a frozen state, and when pulverized to a size larger than the above range, the active ingredient contained in the raw material mixture is sufficiently extracted. If not, the effect intended in the present invention may not be sufficiently exhibited.
또한, 상기 S1 단계에서 원재료 혼합물은 분쇄 전 하기 단계를 포함하는 전처리 단계를 거치는 것일 수 있다:In addition, in the step S1, the raw material mixture may be subjected to a pretreatment step including the following steps before grinding:
a) 다시마, 어성초, 퉁퉁마디, 산수유, 감초 및 길경을 세철 후 혼합하고, 정제수를 투입하여 10 내지 20분간 방치한 후, 물기를 제거하는 단계;a) washing kelp, eoseongcho, cornelian cornus, cornus officinalis, licorice, and gilgyeong, mixing them, adding purified water, leaving them for 10 to 20 minutes, and then removing water;
b) 상기 물기가 제거된 혼합물을 -40 내지 -50℃로 동결시킨 후, 상온에서 3 내지 4시간 동안 방치하는 단계; 및b) freezing the dried mixture at -40 to -50 ° C and leaving it at room temperature for 3 to 4 hours; and
c) 상기 방치된 혼합물을 건조 후 -40 내지 -50℃로 동결시키는 단계.c) freezing the left mixture at -40 to -50 ° C after drying.
상기 a) 단계에서 세절은 원재료의 크기가 0.1 내지 1.0 cm가 되도록 수행되는 것일 수 있으며, 바람직하게는 0.3 내지 0.7 cm가 되도록 수행되는 것일 수 있다. 본 발명의 실시예들에 따르면, 세절은 약 0.5 cm가 되도록 수행되는 것일 수 있으나, 이에 제한되지 않는다.In step a), the cutting may be performed so that the size of the raw material is 0.1 to 1.0 cm, preferably 0.3 to 0.7 cm. According to embodiments of the present invention, the cutting may be performed to be about 0.5 cm, but is not limited thereto.
상기 a) 단계는 정제수를 각 원재료에 침지(침투)시키기 위한 것으로, 정제수가 원재료 혼합물에 충분히 흡수될 수 있는 시간 동안 방치하는 것으로 충분하나, 제조효율상 10 내지 20분 동안 방치하는 것이 바람직할 수 있다.The step a) is for immersing (permeating) the purified water into each raw material, and it is sufficient to leave the purified water for a sufficient time to be absorbed into the raw material mixture, but it may be preferable to leave it for 10 to 20 minutes for manufacturing efficiency. there is.
상기 a) 단계에서 "물기를 제거"는 혼합물 외부에 존재하는 정제수를 제거함을 의미하는 것으로, 예를 들어, 필터를 통과시켜 혼합물과 혼합물 외부에 존재하는 정제수를 제거하는 것일 수 있으나, 이에 제한되는 것은 아니다. 또한, 혼합물 외부에 존재하는 정제수를 90% 내지 99.9%, 바람직하게는 95% 내지 99.9% 제거하는 것을 의미할 수 있으나, 이에 제한되는 것은 아니다.In the step a), "removing water" means removing the purified water present outside the mixture, for example, passing through a filter to remove the mixture and the purified water present outside the mixture, but is limited thereto It is not. In addition, it may mean removing 90% to 99.9%, preferably 95% to 99.9%, of purified water present outside the mixture, but is not limited thereto.
상기 b) 단계는 정제수가 침지된 원재료 혼합물에 대해 동결 및 해동을 수행하는 단계로, 본 발명의 실시예들에 따르면, b) 단계는 3번 이상 반복적이며, 연속적으로 수행되는 것이 바람직할 수 있고, 더욱 바람직하게는 3 내지 5번, 더욱 바람직하게는 4번 또는 5번 반복적이며, 연속적으로 수행되는 것일 수 있으나, 이에 제한되지 않는다.Step b) is a step of freezing and thawing the raw material mixture immersed in purified water, and according to embodiments of the present invention, step b) is repeated three or more times, and may be preferably performed continuously , More preferably 3 to 5 times, more preferably 4 or 5 times, and may be performed continuously, but is not limited thereto.
상기 범위보다 적은 횟수로 수행되는 경우, 전처리로 인한 활성성분의 추출증가 효과가 미미할 수 있으며, 상기 범위보다 많은 횟수로 수행되는 경우, 시간 및 에너지 소비 대비 활성성분의 추출증가 효과가 크지 않을 수 있어 제조효율상 적절하지 않다.When performed less than the above range, the effect of increasing the extraction of active ingredients due to pretreatment may be insignificant, and when performed more times than the above range, the effect of increasing the extraction of active ingredients compared to time and energy consumption may not be large Not suitable for manufacturing efficiency.
후술하는 실험예에서는 b) 단계를 3번 이상 반복적으로 수행하는 경우, 장 기능 개선 및 배변 촉진 효과가 크게 향상될 수 있음을 구체적으로 입증하여, 복합추출물 제조에 있어 전처리 단계를 거치는 경우, 활성성분의 추출수율이 높아질 수 있다는 점을 확인하였다.In the experimental example described later, when step b) is repeatedly performed three or more times, it is specifically demonstrated that the improvement of bowel function and the effect of promoting defecation can be greatly improved, It was confirmed that the extraction yield of can be increased.
본 발명의 복합추출물 제조방법에서 상기 S2 단계는 균질화된 원재료 혼합물 용액을 초음파 추출하는 단계이다.In the composite extract manufacturing method of the present invention, step S2 is a step of ultrasonically extracting the homogenized raw material mixture solution.
상기 S2 단계는 60 내지 80℃에서 수행되며, 상기 온도 범위 미만에서는 원재료 혼합물에 포함된 성분의 추출이 충분히 일어나지 않을 수 있고, 상기 범위를 초과하는 경우, 추출 수율 증가 및 추출 시간 단축될 수는 있으나, 원재료 혼합물에 포함된 활성성분이 열에 의해 변성될 수 있다는 문제가 있다. 따라서, 활성성분의 추출수율 및 온전성 측면을 모두 고려하면 상기 범위의 온도가 매우 유리하다.The S2 step is performed at 60 to 80 ° C., and extraction of components included in the raw material mixture may not sufficiently occur below the above temperature range, and when the above range is exceeded, the extraction yield may increase and the extraction time may be shortened. However, there is a problem that the active ingredients included in the raw material mixture may be denatured by heat. Therefore, considering both the extraction yield and integrity of the active ingredient, the temperature in the above range is very advantageous.
상기 S2 단계는 2시간 내지 4시간 동안 수행될 수 있으며, 본 발명의 실시예들에 따르면, 약 3시간 동안 수행되는 것일 수 있으나, 이에 제한되지 않는다.The step S2 may be performed for 2 to 4 hours, and according to embodiments of the present invention, it may be performed for about 3 hours, but is not limited thereto.
상기 시간 범위 미만으로 추출되는 경우, 원재료 혼합물에 포함된 활성성분의 추출이 충분히 일어나지 않을 수 있고, 상기 범위를 초과하는 경우, 시간 대비 활성성분의 추출수율이 낮아져 제조효율상 적절하지 않을 수 있다.If the extraction time is less than the above range, the extraction of the active ingredient contained in the raw material mixture may not sufficiently occur, and if the above range is exceeded, the extraction yield of the active ingredient relative to the time may be lowered, which may not be appropriate in terms of manufacturing efficiency.
또한, 초음파 추출기가 특정 위치에 초점을 갖고 조사될 경우, 매질의 온도가 상승하여 원재료에 포함된 활성성분이 파괴되거나 변성될 수 있으므로 상기 S2 단계는 초음파 추출은 지속적으로 교반을 수반하며 수행되는 것일 수 있으며, 상기 교반은 초음파 조사 기기에 구비된 교반 장치에 의해 수행될 수 있고, 별도로 구비된 교반 장치를 통해 수행될 수 있다.In addition, when the ultrasonic extractor is irradiated with a focus on a specific location, the temperature of the medium rises and the active ingredient contained in the raw material may be destroyed or denatured. The stirring may be performed by a stirring device provided in the ultrasonic irradiation device, or may be performed by a separately provided stirring device.
본 발명의 복합추출물 제조방법에서 상기 S3 및 S6 단계는 잔사물과 초음파 추출에 의해 활성물질이 포함되어 있는 여과액을 분리하는 단계이며, 상기 분리는 공지되어 있는 방법을 통해 수행될 수 있다.In the composite extract manufacturing method of the present invention, the steps S3 and S6 are steps of separating the residue and the filtrate containing the active material by ultrasonic extraction, and the separation may be performed through a known method.
본 발명의 복합추출물 제조방법에서 상기 S4 및 S5 단계는 S3 단계에서 분리되고 남은 잔사물을 열수추출하는 단계이다.In the composite extract manufacturing method of the present invention, the steps S4 and S5 are steps of hot water extraction of the residue remaining after being separated in step S3.
상기 S5 단계에서, 용매는 정제수인 것이 바람직하며, 유기용매 사용 시 잔사물에 남은 추출하고자 하는 활성성분의 수율이 낮아질 수 있다.In the step S5, the solvent is preferably purified water, and when an organic solvent is used, the yield of the active ingredient to be extracted remaining in the residue may be lowered.
상기 S5 단계는 130 내지 150℃에서 수행되는 것일 수 있으며, 2 내지 4시간 동안 수행되는 것일 수 있다.The step S5 may be performed at 130 to 150 ° C, and may be performed for 2 to 4 hours.
상기 온도 범위 미만에서는 잔사물에 포함된 성분의 추출이 충분히 일어나지 않을 수 있고, 상기 범위를 초과하는 경우, 추출 수율 증가 및 추출 시간 단축될 수는 있으나, 잔사물에 포함된 활성성분이 열에 의해 변성될 수 있다는 문제가 있다. 따라서, 활성성분의 추출수율 및 온전성 측면을 모두 고려하면 상기 범위의 온도가 매우 유리하다.Below the above temperature range, extraction of components contained in the residue may not sufficiently occur, and when it exceeds the above range, the extraction yield may increase and the extraction time may be shortened, but the active ingredient contained in the residue may be denatured by heat. There is a problem with what could be. Therefore, considering both the extraction yield and integrity of the active ingredient, the temperature in the above range is very advantageous.
또한, 상기 시간 범위 미만으로 추출되는 경우, 잔사물에 포함된 활성성분의 추출이 충분히 일어나지 않을 수 있고, 상기 범위를 초과하는 경우, 시간 대비 활성성분의 추출수율이 낮아져 제조효율상 적절하지 않을 수 있다.In addition, when the extraction time is less than the above range, extraction of the active ingredient contained in the residue may not sufficiently occur, and when the above range is exceeded, the extraction yield of the active ingredient relative to the time is lowered, which may not be appropriate in terms of manufacturing efficiency. there is.
본 발명의 복합추출물 제조방법에서 상기 S2 및 S3 단계 사이; 및 S5 및 S6 단계 사이에 수득된 추출물을 2 내지 6℃로 냉각시키고, 4 내지 6시간 동안 방치(숙성)시키는 단계를 더 포함할 수 있으며, 이로 인해 추출된 활성성분이 가진 장 기능 개선 및 배변 촉진 효과가 증대되는 효과를 나타낼 수 있다.Between the steps S2 and S3 in the composite extract manufacturing method of the present invention; And cooling the extract obtained between steps S5 and S6 at 2 to 6 ° C and leaving (aging) for 4 to 6 hours, thereby improving intestinal function and bowel movement with the extracted active ingredient. It can show the effect of increasing the promotion effect.
본 발명의 복합추출물 제조방법에서 S7 단계는 상기 S3 및 상기 S6 단계에서 분리된 여과액을 혼합하는 단계로, 각각의 다른 추출법을 연속적이고 순차적으로 수행한 제조방법에 의해 원재료로부터 최대로 추출된 성분을 혼합하는 단계이다.In the composite extract manufacturing method of the present invention, step S7 is a step of mixing the filtrate separated in the step S3 and step S6, and the component extracted from the raw material by the manufacturing method in which each different extraction method is continuously and sequentially performed This is the mixing step.
본 발명의 복합추출물 제조방법에서 상기 S1 내지 S7 단계는 연속적이고 순차적으로 수행하는 것이 원재료로부터 최대로 활성성분을 추출하는데 유리할 수 있으며, 후술하는 실험예에서는 S1 내지 S7 단계는 연속적이고 순차적으로 수행될 경우 장 기능 개선 및 배변 촉진 효과가 증대될 수 있음을 구체적으로 입증하였다.In the composite extract manufacturing method of the present invention, it may be advantageous to perform the steps S1 to S7 continuously and sequentially to extract the active ingredient from the raw material to the maximum, and in the experimental example to be described later, the steps S1 to S7 will be performed continuously and sequentially. In this case, it was specifically demonstrated that the effect of improving bowel function and promoting defecation can be increased.
본 발명에서 상기 조성물은 혼합유산균을 더 포함하는 것일 수 있다. In the present invention, the composition may further include mixed lactic acid bacteria.
상기 혼합유산균은 락토바실러스 애시도필러스(Lactobacillus acidophilus), 락토바실러스 비피더스(Lactobacillus bifidus), 락토바실러스 애시더필로스(lactobacilus acidophilus), 스트렙토코커스 패칼리스(Streptococcus faecalis), 스트렙토코커스 패시움(Streptococcus faecium), 바실러스 서브틸리스(Bacillus subtilis), 바실러스 리케니포미스(Bacillus licheniformis), 바실러스 폴리퍼멘티커스(Bacillus polyfermenticus), 바실러스 메센테리커스(Bacillus mesentericus), 사카로마이세스 세레비제(Saccharomyces cerevisiae), 클로스트리디움 부티리컴(Clostridium butyricum), 피디오코커스 펜토사세우스(Pediococcus pentosaceus), 엔터로코커스 패시움(Enterococcus faecium) 및 비피도 박테리움 롱검(Bifidobacterium longum)으로 구성된 군으로부터 선택되는 하나 이상일 수 있으나, 이에 제한되는 것은 아니며, 장 기능 개선 및 배변 촉진 효과를 가지는 것으로 알려진 유산균은 어느것이든 사용될 수 있다.The mixed lactic acid bacteria are Lactobacillus acidophilus, Lactobacillus bifidus, Lactobacilus acidophilus, Streptococcus faecalis, Streptococcus faecium , Bacillus subtilis, Bacillus licheniformis, Bacillus polyfermenticus, Bacillus mesentericus, Saccharomyces cerevisiae, It may be one or more selected from the group consisting of Clostridium butyricum, Pediococcus pentosaceus, Enterococcus faecium and Bifidobacterium longum. However, it is not limited thereto, and any lactic acid bacteria known to have an effect of improving bowel function and promoting bowel movement may be used.
본 발명에서 "건강기능식품"은 일상 식사에서 결핍되기 쉬운 영양소나 인체에 유용한 기능을 가진 원료나 성분을 사용하여 제조한 식품으로, 인체의 건강을 유지하는데 도움을 주는 식품을 의미하나, 이에 제한되는 것은 아니며 통상적인 의미의 건강식품을 모두 포함한다.In the present invention, "health functional food" is a food prepared using raw materials or components having useful functions for the human body or nutrients that are likely to be deficient in daily meals, and refers to foods that help maintain the health of the human body, but are limited thereto. It does not mean that it includes all health foods in the usual sense.
본 발명에서 상기 건강기능식품은 정제, 캡슐, 환, 과립, 액상, 분말, 편상, 시럽, 겔, 젤리, 바, 필름 등의 제형으로 식품 첨가물과 혼합되어 건강기능식품으로 제품화 될 수 있다.In the present invention, the health functional food may be mixed with food additives in the form of tablets, capsules, pills, granules, liquids, powders, flakes, syrups, gels, jellies, bars, films, etc. to be commercialized as health functional foods.
상기 건강기능식품에 혼합될 수 있는 식품 첨가물은 예를 들어, 향미제, 감미제, 풍미제, 보전제, 천연 탄수화물, 영양제, 비타민, 전해질, 착색제, 펙스탄 및 그 의 염, 알긴산 및 그의 염, 유기산, 보호성 콜로이드 증점제, pH 조절제, 안정화제, 방부제, 글리세린, 알코올 등일 수 있으나, 이에 제한되는 것은 아니며, 식품에 첨가할 수 있는 것으로 본 발명의 건강기능식품 조성물에 유리한 효과를 나타낼 수 있는 것이라면 제한없이 포함될 수 있다.Food additives that can be mixed in the health functional food include, for example, flavoring agents, sweetening agents, flavoring agents, preservatives, natural carbohydrates, nutrients, vitamins, electrolytes, coloring agents, pectanes and salts thereof, alginic acid and salts thereof, It may be an organic acid, a protective colloidal thickener, a pH regulator, a stabilizer, a preservative, glycerin, alcohol, etc., but is not limited thereto. Can be included without limitation.
또한, 본 발명의 건강기능식품 조성물은 유효성분 이외에, 장 기능 개선 및 배변 촉진 효과의 상승·보강을 위하여, 유사활성의 부가를 통한 복용이나 섭취의 편리성을 증진시키기 위하여, 당업계에서 이미 안전성이 검증되고 해당 활성을 갖는 것으로 공지된 임의의 화합물이나 천연 추출물을 추가로 포함할 수 있다. 이러한 화합물 또는 추출물에는 각국 약전(한국에서는 "대한민국약전"), 각국 건강기능식품공전(한국에서는 식약처 고시인 "건강기능식품 기준 및 규격"임) 등의 공정서에 실려 있는 화합물 또는 추출물, 의약품의 제조·판매를 규율하는 각국의 법률(한국에서는 "약사법"임)에 따라 품목 허가를 받은 화합물 또는 추출물, 건강기능식품의 제조·판매를 규율하는 각국 법률(한국에서는 「건강기능식품에관한법률」임)에 따라 기능성이 인정된 화합물 또는 추출물이 포함된다.In addition, the health functional food composition of the present invention is already safe in the art in order to enhance the convenience of intake or intake through the addition of similar activities in order to improve intestinal function and increase or reinforce the effect of promoting defecation, in addition to the active ingredients. It can further include any compound or natural extract known to have this verified and having that activity. These compounds or extracts include compounds or extracts, pharmaceuticals listed in compendials such as pharmacopoeia of each country ("Korean Pharmacopoeia" in Korea) and health functional food codes of each country (in Korea, it is "standards and specifications for health functional foods", a notice of the Ministry of Food and Drug Safety). The laws of each country regulating the manufacture and sale of compounds or extracts and health functional foods that have been licensed under each country's laws ("Pharmaceutical Affairs Act" in Korea) governing the manufacture and sale of health functional foods ("Health Functional Foods Act" in Korea) ”), compounds or extracts whose functionality has been recognized are included.
본 발명의 다른 양태는, 차전자피; 및 다시마, 어성초, 퉁퉁마디, 산수유, 감초 및 길경의 복합추출물;을 포함하는 장 기능 개선 및 배변 촉진용 건강기능식품을 제조하는 방법을 제공한다.Another aspect of the present invention, psyllium husk; It provides a method for preparing a health functional food for improving bowel function and promoting defecation, including; and complex extracts of kelp, eoseongcho, tungtungmadi, cornus officinalis, licorice, and cilantro.
본 발명의 장 기능 개선 및 배변 촉진용 건강기능식품 제조방법에서 반대되는 언급이 없는 한 상기 장 기능 개선 및 배변 촉진용 건강기능식품 조성물에서 서술한 바와 동일하며, 명세서의 과도한 반복을 피하기 위해 설명은 생략한다.Unless otherwise stated in the manufacturing method of health functional food for improving bowel function and promoting defecation of the present invention, it is the same as described in the health functional food composition for improving bowel function and promoting defecation, and the description is to avoid excessive repetition of the specification. omit
본 발명의 건강기능식품 조성물은 배변빈도, 배변경도, 배변통증, 가스발생, 잔변감, 복부팽만 등 장 기능 및 배변과 관련된 현상들을 개선시킬 수 있으므로, 장 기능 개선 및 배변 촉진용으로 유용하게 사용될 수 있다.Since the health functional food composition of the present invention can improve bowel function and bowel function-related phenomena such as bowel movement frequency, bowel movement, bowel pain, gas generation, residual stool sensation, and abdominal distension, it can be usefully used for improving bowel function and promoting bowel movement. can
또한, 본 발명의 장 기능 개선 및 배변 촉진용 건강기능식품 조성물은 다양한 천연물 원재료로부터 추출된 활성성분을 포함하므로, 해당 원재료가 가진 유용한 효과를 함께 누릴 수 있다.In addition, since the health functional food composition for improving bowel function and promoting defecation of the present invention includes active ingredients extracted from various natural raw materials, useful effects of the raw materials can be enjoyed together.
또한, 본 발명의 장 기능 개선 및 배변 촉진용 건강기능식품 조성물은 맛, 향 등의 기호도가 높아 장기적으로 복용이 가능하므로, 장 기능 개선 및 배변 촉진을 위한 목적 달성에 용이하게 사용될 수 있다.In addition, since the health functional food composition for improving bowel function and promoting bowel movement of the present invention has high preference for taste and aroma, and can be taken for a long period of time, it can be easily used to achieve the purpose of improving bowel function and promoting bowel movement.
이하 본 발명을 실시예에 의해 보다 상세하게 설명한다. 그러나 이들 실시예는 본 발명을 예시적으로 설명하기 위한 것으로, 본 발명의 범위가 이들 실시예에 의해 제한되는 것은 아니다. 또한, 본 명세서에서 특별히 정의되지 않은 용어들에 대해서는 본 발명이 속하는 기술 분야에서 통상적으로 사용되는 의미를 갖는 것으로 이해되어야 할 것이다.Hereinafter, the present invention will be described in more detail by examples. However, these examples are intended to illustrate the present invention by way of example, and the scope of the present invention is not limited by these examples. In addition, terms not specifically defined in this specification should be understood to have meanings commonly used in the technical field to which the present invention belongs.
실시예Example
(1) 원재료 복합추출물의 제조(1) Manufacture of raw material composite extract
1) 원재료 혼합물의 전처리 단계1) Pretreatment step of raw material mixture
1-1) 다시마, 어성초, 퉁퉁마디, 산수유, 감초 및 길경(동대문구 소재 한약재시장 또는 인터넷 오픈마켓에서 구매)를 깨끗하게 세척한 후, 약 0.5 cm로 세절하고 1:1:1:1:1:1의 중량비로 고르게 혼합하였다. 그 후, 상기 혼합물 300 g에 정제수를 넣고, 약 15분간 방치하여 원재료에 정제수가 흡수될 수 있게 하였으며, 원재료 혼합물을 거름망으로 걸러내어 물기를 제거하였다.1-1) After washing kelp, eoseongcho, cornelian cornus, licorice, and gilgyeong (purchased at the oriental medicine market in Dongdaemun-gu or online open market), cut them into about 0.5 cm and cut them 1:1:1:1:1: They were evenly mixed at a weight ratio of 1. Thereafter, purified water was added to 300 g of the mixture, left for about 15 minutes to allow the purified water to be absorbed into the raw material, and the raw material mixture was filtered through a sieve to remove moisture.
1-2) 상기 수득된 원재료 혼합물을 동결기(QF-700)를 사용하여 약 -40 내지 -50℃의 초저온으로 동결시키고, 상기 동결시킨 원재료 혼합물을 상온에 꺼내어 약 3 내지 4시간 동안 방치(해동)하였으며, 상기 과정(동결 및 해동)은 3회 추가(총 4회)로 반복하였다.1-2) The obtained raw material mixture is frozen at a very low temperature of about -40 to -50 ° C using a freezer (QF-700), and the frozen raw material mixture is brought to room temperature and left for about 3 to 4 hours ( thawing), and the above process (freezing and thawing) was repeated 3 additional times (4 times in total).
1-3) 상기 동결 및 해동 단계를 거친 원재료 혼합물을 열풍건조로 건조시킨 다음, 약 -40 내지 -50℃의 초저온으로 동결시켜 원재료 혼합물 전처리 단계를 완료하였다.1-3) The raw material mixture that had undergone the freezing and thawing steps was dried by hot air drying, and then frozen at a very low temperature of about -40 to -50 ° C to complete the raw material mixture pretreatment step.
2) 원재료 복합추출물의 제조2) Manufacture of raw material composite extract
2-1) 상기 전처리된 원재료 혼합물 100 g을 동결상태에서 분쇄기를 통해 약 400 내지 500 ㎛ 크기로 분쇄하고, 약 10배 부피의 80%(w/v) 에탄올을 가한 후, 10분간 교반하여 균질화하였다.2-1) Grind 100 g of the pretreated raw material mixture in a frozen state through a grinder to a size of about 400 to 500 μm, add about 10 times the volume of 80% (w / v) ethanol, and then stir for 10 minutes to homogenize did
2-2) 상기 균질화된 원재료 혼합물을 60 내지 80℃가 되도록 유지시키면서 초음파 추출기(Power sonica, 화신테크)를 이용하여 3시간 동안 지속적으로 교반하면서 추출하였다.2-2) The homogenized raw material mixture was extracted with continuous stirring for 3 hours using an ultrasonic extractor (Power Sonica, Hwashin Tech) while maintaining the temperature at 60 to 80 ° C.
이후, 상기 수득된 추출물을 4℃로 냉각시키고, 약 5시간 동안 방치시킨 후, 필터(6 ㎛)로 여과하여 여과액 및 잔사물을 분리하고, 여과액(제1 추출물)은 따로 보관하였다.Thereafter, the obtained extract was cooled to 4° C., allowed to stand for about 5 hours, and filtered through a filter (6 μm) to separate the filtrate and residue, and the filtrate (first extract) was stored separately.
2-3) 상기 분리된 잔사물에 약 10배 부피의 정제수를 가한 후, 10분간 교반하여 균질화하고, 약 130 내지 150℃에서 3시간 동안 열수추출하고, 수득된 추출물을 4℃로 냉각시키고, 약 5시간 동안 방치시킨 후, 필터(6 ㎛)로 여과하여 여과액 및 잔사물을 분리하고, 여과액(제2 추출물)은 따로 보관하였다.2-3) After adding about 10 times the volume of purified water to the separated residue, homogenizing by stirring for 10 minutes, extracting with hot water at about 130 to 150 ° C for 3 hours, cooling the obtained extract to 4 ° C, After allowing to stand for about 5 hours, the mixture was filtered through a filter (6 μm) to separate the filtrate and residue, and the filtrate (second extract) was stored separately.
2-4) 이후, 상기 제1 및 제2 추출물을 혼합하고, 감압농축 및 동결건조(Eyela NE, Tokyo, Japan)하여 원재료 복합추출물을 제조하였다.2-4) thereafter, the first and second extracts were mixed, concentrated under reduced pressure and freeze-dried (Eyela NE, Tokyo, Japan) to prepare a raw material composite extract.
(2) (2) 차전자피Psyllium Husk 및 원재료 복합추출물을 포함하는 환의 제조 And manufacture of pills containing raw material composite extracts
차전자피(오픈마켓에서 분말상태로 구입) 및 원재료 복합추출물을 1:1의 중량비로 혼합하고, 공지된 환 제조방법을 통해 환 전체 중량 대비 차전자피 및 원재료 복합추출물의 혼합물 80 중량%, 수산화마그네슘 0.4 중량%, 황산마그네슘 0.4 중량%, 프락토올리고당 2.4 중량%, 소금 4 중량%를 포함하는 환을 제조하였다.Psyllium hull (purchased in powder form at an open market) and raw material composite extract were mixed at a weight ratio of 1:1, and 80% by weight of the mixture of psyllium hull and raw material composite extract, 0.4 weight of magnesium hydroxide, based on the total weight of the pill through a known pill manufacturing method %, a ring containing 0.4% by weight of magnesium sulfate, 2.4% by weight of fructooligosaccharide, and 4% by weight of salt was prepared.
비교예comparative example 1 One
실시예의 원재료 혼합물의 전처리 단계에 있어서, 1-2 단계의 동결 및 해동을 총 2회 반복한 것을 제외하고는 실시예와 실질적으로 동일한 방법을 통해 차전자피 및 원재료 복합추출물의 혼합물을 포함하는 환을 제조하였다.In the pretreatment step of the raw material mixture of Example, a ring containing a mixture of psyllium hull and raw material composite extract was prepared through substantially the same method as in Example, except that the freezing and thawing of steps 1-2 were repeated a total of two times. did
비교예comparative example 2 2
실시예의 원재료 복합추출물의 제조에 있어서, 하기의 방법으로 추출한 것을 제외하고는 실시예와 실질적으로 동일한 방법을 통해 차전자피 및 원재료 복합추출물의 혼합물을 포함하는 환을 제조하였다.In the preparation of the raw material composite extract of Example, a ring containing a mixture of psyllium hull and raw material composite extract was prepared through substantially the same method as in Example, except that it was extracted by the following method.
3-1) 상기 실시예의 1-1 내지 1-3 단계로 전처리된 원재료 혼합물 100 g을 동결상태에서 분쇄기를 통해 약 400 내지 500 ㎛ 크기로 분쇄하고, 약 10배 부피의 정제수를 투여한 후, 10분간 교반하여 균질화하였다.3-1) 100 g of the raw material mixture pretreated in steps 1-1 to 1-3 of the above example was pulverized in a frozen state through a grinder to a size of about 400 to 500 μm, and about 10 times the volume of purified water was administered, It was homogenized by stirring for 10 minutes.
3-2) 상기 균질화된 원재료 혼합물을 약 130 내지 150℃에서 3시간 동안 열수추출하고, 수득된 추출물을 4℃로 냉각시키고, 약 5시간 동안 방치시킨 후, 필터(6 ㎛)로 여과하여 여과액 및 잔사물을 분리하고, 여과액(제1' 추출물)은 따로 보관하였다.3-2) The homogenized raw material mixture was subjected to hot water extraction at about 130 to 150 ° C. for 3 hours, the obtained extract was cooled to 4 ° C., left for about 5 hours, and then filtered through a filter (6 μm). The liquid and residue were separated, and the filtrate (first 'extract) was stored separately.
3-3) 상기 분리된 잔사물에 약 10배 부피의 80%(w/v) 에탄올을 가한 후, 10분간 교반하여 균질화하고, 상기 균질화된 원재료 혼합물을 60 내지 80℃가 되도록 유지시키면서 초음파 추출기(Power sonica, 화신테크)를 이용하여 3시간 동안 지속적으로 교반하면서 추출하였다.3-3) After adding about 10 times the volume of 80% (w/v) ethanol to the separated residue, homogenize by stirring for 10 minutes, and maintain the homogenized raw material mixture at 60 to 80 ° C. Ultrasonic extractor (Power Sonica, Hwashin Tech) was extracted while continuously stirring for 3 hours.
이후, 상기 수득된 추출물을 4
3-4) 이후, 상기 제1' 및 제2' 추출물을 혼합하고, 감압농축 및 동결건조(Eyela NE, Tokyo, Japan)하여 원재료 복합추출물을 제조하였다.3-4), the first 'and second' extracts were mixed, concentrated under reduced pressure and freeze-dried (Eyela NE, Tokyo, Japan) to prepare a raw material composite extract.
실험예Experimental Example . 장 기능 개선 및 배변 촉진 효과 확인. Improvement of bowel function and confirmation of defecation promotion effect
본 발명의 조성물이 우수한 장 기능 개선 및 배변 촉진 효과를 가지는지 여부를 확인하기 위해 다음과 같이 실험을 수행하였다.In order to confirm whether the composition of the present invention has an excellent intestinal function improvement and defecation promoting effect, an experiment was conducted as follows.
실험 참가자는 평소에 변비가 빈번하게 발생하는 20 내지 40대 여성 40명이었으며, 4개의 군으로 분류하여 실시예, 비교예 1 및 2의 환을 2주일간 매일 아침/저녁 10 g씩 충분한 물과 함께 섭취하도록 하였으며, 되도록이면 일정한 시간에 섭취하도록 하였다.The participants in the experiment were 40 women in their 20s to 40s who had frequent constipation, and were classified into 4 groups, taking the pills of Examples and Comparative Examples 1 and 2 for 2 weeks every morning/evening for 2 weeks with sufficient water. It was intended to be consumed, and, if possible, to be consumed at a regular time.
또한, 실험기간 중 변비 개선을 위한 기능성 제품이나 의약품은 섭취하지 않도록 하였고, 식사는 평소와 동일하게 할 것을 권고하였다.In addition, during the experiment period, functional products or medicines for improving constipation were not consumed, and meals were recommended to be the same as usual.
평가 기준은 하기와 같으며, 결과는 평균값으로 표 1에 나타내었다.The evaluation criteria are as follows, and the results are shown in Table 1 as average values.
[평가기준][Evaluation standard]
1. 배변빈도(%) - 실험기간 동안 배변 성공한 날의 일 수로 산정1. Defecation frequency (%) - Calculated by the number of days of successful defecation during the experiment period
2. 배변경도 - 설사 1점, 묽은변 2점, 정상변 3점, 딱딱한변 4점, 작은변 5점2. Change in bowel movement - diarrhea 1 point, loose stool 2 points, normal stool 3 points, hard stool 4 points, small stool 5 points
3. 배변통증 - 전혀없음 1점, 없는편 2점, 보통 3점, 있는편 4점, 심함 5점3. Bowel pain - none at all 1 point, none 2 points, moderate 3 points, present 4 points, severe 5 points
4. 가스발생 - 전혀없음 1점, 없는편 2점, 보통 3점, 있는편 4점, 심함 5점4. Gas generation - none at all 1 point, none 2 points, moderate 3 points, present 4 points, severe 5 points
5. 잔변감 - 전혀없음 1점, 없는편 2점, 보통 3점, 있는편 4점, 심함 5점5. Sense of change - not at all 1 point, none 2 points, moderate 3 points, present 4 points, severe 5 points
6. 복부팽만 - 전혀없음 1점, 없는편 2점, 보통 3점, 있는편 4점, 심함 5점6. Abdominal distension - none at all 1 point, none 2 points, moderate 3 points, present 4 points, severe 5 points
(*차전자피 및 복합추출물이 포함되지 않은 환 제공)( * Provided pills that do not contain psyllium hulls and complex extracts)
상기 표 1에서 확인할 수 있는 바와 같이, 실시예를 투여한 실험 참가자들은 대조군 대비 배변빈도, 배변경도, 배변통증, 가스발생, 잔변감 및 복부팽만에서 모두 개선되는 효과를 나타내었다.As can be seen in Table 1, the experiment participants who administered the examples showed the effect of improving all of the defecation frequency, defecation change, defecation pain, gas generation, residual stool and abdominal distension compared to the control group.
또한, 복합추?yㅜㄹ에 있어서 제조방법상의 차이를 둔 비교예 1 및 비교예 2의 경우도 각각 배변빈도, 배변경도, 배변통증, 가스발생, 잔변감 및 복부팽만의 개선되는 효과가 있었으나, 실시예는 이와 대비해서도 유의미한 개선 효과를 나타내었다. 이는 제조방법의 차이에 의해서도 장 기능 개선 및 배변 촉진 효과를 상당부분 상승시킬 수 있음을 확인한 것이다.In addition, in the case of Comparative Example 1 and Comparative Example 2, which differed in the manufacturing method in the composite weight loss, there was an effect of improving the frequency of defecation, degree of defecation, defecation pain, gas generation, residual stool and abdominal bloating, respectively, In contrast, the examples showed a significant improvement effect. This confirms that the improvement of bowel function and the effect of promoting defecation can be significantly increased even by the difference in manufacturing method.
Claims (5)
다시마, 어성초, 퉁퉁마디, 산수유, 감초 및 길경의 복합추출물;을 포함하는 장 기능 개선 및 배변 촉진용 건강기능식품 조성물에 있어서,
상기 복합추출물은,
S1) 다시마, 어성초, 퉁퉁마디, 산수유, 감초 및 길경을 세철 후 혼합하고, 정제수를 투입하여 10 내지 20분간 방치한 후, 물기를 제거하는 단계;
S2) 상기 물기가 제거된 혼합물을 -40 내지 -50℃로 동결시킨 후, 상온에서 3 내지 4시간 동안 방치하는 단계;
S3) 상기 방치된 혼합물을 건조 후 -40 내지 -50℃로 동결시키는 단계;
S4) 상기 동결 상태의 원재료 혼합물을 분쇄하고, 상기 분쇄된 원재료 혼합물에 80%(w/v) 에탄올을 투입한 후, 교반하여 균질화하는 단계;
S5) 상기 균질화된 원재료 혼합물 용액을 60 내지 80℃에서 2 내지 4시간 동안 초음파 처리하여 초음파추출하는 단계;
S6) 상기 초음파 처리된 용액을 여과하여 여과액 및 잔사물로 분리하는 단계;
S7) 상기 분리된 잔사물에 정제수를 투입한 후, 교반하여 균질화하는 단계;
S8) 상기 균질화된 용액을 130 내지 150℃에서 2 내지 4시간 동안 열수추출하는 단계;
S9) 상기 열처리된 용액을 여과하여 여과액 및 잔사물로 분리하는 단계; 및
S10) 상기 S6 및 S9 단계에서 분리된 여과액을 혼합하는 단계;를 포함하는 방법에 의해 제조된 것이며,
상기 S2 단계는 3 내지 5회 반복되는 것이고,
상기 S5 단계는 지속적인 교반을 수반하면서 수행되는 것인 장 기능 개선 및 배변 촉진용 건강기능식품 조성물.psyllium husk; and
In the health functional food composition for improving bowel function and promoting defecation,
The composite extract,
S1) washing kelp, eoseongcho, cornelian cornus, cornus officinalis, licorice, and gilgyeong, mixing them, adding purified water, leaving them for 10 to 20 minutes, and then removing water;
S2) freezing the dried mixture at -40 to -50 ° C and leaving it at room temperature for 3 to 4 hours;
S3) freezing the left mixture at -40 to -50 ° C after drying;
S4) pulverizing the raw material mixture in a frozen state, adding 80% (w/v) ethanol to the pulverized raw material mixture, and homogenizing by stirring;
S5) ultrasonically extracting the homogenized raw material mixture solution by ultrasonic treatment at 60 to 80 ° C. for 2 to 4 hours;
S6) filtering the sonicated solution to separate into a filtrate and a residue;
S7) adding purified water to the separated residue and homogenizing it by stirring;
S8) hot water extraction of the homogenized solution at 130 to 150° C. for 2 to 4 hours;
S9) filtering the heat-treated solution to separate into a filtrate and a residue; and
It is prepared by a method comprising; S10) mixing the filtrate separated in steps S6 and S9;
Step S2 is repeated 3 to 5 times,
The S5 step is a health functional food composition for improving intestinal function and promoting defecation, which is performed while accompanied by continuous stirring.
상기 복합추출물은 다시마, 어성초, 퉁퉁마디, 산수유, 감초 및 길경을 1:1:1:1:1:1의 중량비로 혼합한 원재료 혼합물로부터 추출된 것인 장 기능 개선 및 배변 촉진용 건강기능식품 조성물.According to claim 1,
The complex extract is a health functional food for improving bowel function and promoting defecation, which is extracted from a mixture of raw materials obtained by mixing kelp, eoseongcho, cornelian cornus, licorice, and ginseng in a weight ratio of 1: 1: 1: 1: 1: 1 composition.
상기 차전자피 및 복합추출물은 1:1의 중량비로 포함되는 것인 장 기능 개선 및 배변 촉진용 건강기능식품 조성물.According to claim 1,
The psyllium husk and complex extract is a health functional food composition for improving intestinal function and promoting defecation, which is included in a weight ratio of 1: 1.
상기 S5 및 S6 단계 사이; 및 S8 및 S9 단계 사이에 수득된 추출물을 2 내지 6℃로 냉각시키고, 4 내지 6시간 동안 방치시키는 단계를 더 포함하는 장 기능 개선 및 배변 촉진용 건강기능식품 조성물.According to claim 1,
Between the steps S5 and S6; And cooling the extract obtained between steps S8 and S9 at 2 to 6 ° C., and leaving it for 4 to 6 hours. Functional food composition for improving bowel function and stimulating defecation.
상기 조성물은 혼합유산균을 더 포함하는 것인 장 기능 개선 및 배변 촉진용 건강기능식품 조성물.According to claim 1,
The composition is a health functional food composition for improving bowel function and promoting defecation, further comprising mixed lactic acid bacteria.
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