KR20220063388A - Cosmetic composition comprising glutathione, Maqui Berry extract and Mulberry root extract - Google Patents
Cosmetic composition comprising glutathione, Maqui Berry extract and Mulberry root extract Download PDFInfo
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- KR20220063388A KR20220063388A KR1020200149171A KR20200149171A KR20220063388A KR 20220063388 A KR20220063388 A KR 20220063388A KR 1020200149171 A KR1020200149171 A KR 1020200149171A KR 20200149171 A KR20200149171 A KR 20200149171A KR 20220063388 A KR20220063388 A KR 20220063388A
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- A23V2200/318—Foods, ingredients or supplements having a functional effect on health having an effect on skin health and hair or coat
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- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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- A23V2250/00—Food ingredients
- A23V2250/30—Other Organic compounds
- A23V2250/31—Glutathione
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Abstract
Description
본 발명은 글루타치온, 마키베리 추출물 및 상백피 추출물을 유효성분으로 포함하는 화장료 조성물, 의약외품 조성물, 식품 조성물, 이너뷰티 조성물에 관한 것이다. 구체적으로, 본 발명은 글루타치온, 마키베리 추출물 및 상백피 추출물을 유효성분으로 포함하는 피부 미백용, 피부 트러블 개선용, 피부 보습용, 피부 주름 개선용 조성물에 관한 것이다.The present invention relates to a cosmetic composition, a quasi-drug composition, a food composition, and an inner beauty composition comprising glutathione, a macchiberry extract, and an extract of sagebrush as an active ingredient. Specifically, the present invention relates to a composition for skin whitening, skin trouble improvement, skin moisturizing, and skin wrinkle improvement comprising glutathione, macchiberry extract, and sangbaek skin extract as active ingredients.
인간의 피부색을 결정하는 요인에는 여러가지가 존재하는데, 멜라닌 색소를 생성하는 멜라노사이트(melanocyte)의 활성, 혈관의 분포와 피부의 두께 기타 유전적인 요인들이 중요하게 작용한다. 이 중 특히 티로시나제 등 여러 효소의 작용에 의해 인체 내 멜라노사이트가 멜라닌 색소를 생성하는 활성이 특히 가장 중요한 요인으로 알려져 있다. There are various factors that determine the color of human skin, and the activity of melanocytes that produce melanin pigment, the distribution of blood vessels and the thickness of the skin and other genetic factors play an important role. Among them, it is known that the activity of melanocytes in the human body to generate melanin pigment by the action of various enzymes such as tyrosinase is the most important factor.
한편, 멜라닌(melanin)은 페놀 화합물의 산화중합에 의하여 생성되는 흑갈색의 색소로, 인간의 피부색을 결정할 뿐 아니라 자외선을 흡수하거나 Free Radical Scavenger로서 항산화 효과를 나타내어 피부의 보호 작용을 하는 등 피부 내에서 중요한 역할을 담당하고 있다. 그러나, 피부가 자외선에 과도하게 노출되거나, 호르몬 변화나 스트레스 등 요인으로 인해 멜라닌이 과잉 생산될 경우, 피부에 색소 침착을 가져와 피부색이 어둡고 탁해지거나 기미나 주근깨 등을 유발하여 피부 미용에는 부정적으로 작용할 수 있다. On the other hand, melanin is a blackish-brown pigment produced by oxidative polymerization of phenolic compounds, which not only determines the color of human skin, but also absorbs ultraviolet rays or exhibits antioxidant effects as a free radical scavenger to protect the skin. plays an important role. However, if the skin is excessively exposed to UV rays or excessive production of melanin is caused by factors such as hormonal changes or stress, it may cause pigmentation in the skin and cause dark and cloudy skin color, spots or freckles, etc. can
일반적으로 알려진 미백 성분으로, 코지산(kojic acid) 또는 알부틴 (arbutin) 등과 같은 티로시나제 효소활성을 억제하는 물질, 하이드로퀴논 (Hydroquinone), 비타민 C 또는 이들의 유도체와 각종 식물 추출물 등이 있다. 이들은 멜라닌 색소의 합성을 저해함으로써 피부 톤을 밝게 하고 피부 미백을 달성하거나, 자외선, 호르몬 또는 유전적 요소에 기인한 기미나 주근깨 등 피부의 과색소 침착증을 개선할 수 있다. 그러나, 이들은 피부 적용 시 자극과 발적 등 안전성의 문제로 사용량의 제한이 있거나, 효과가 미미하여 실질적인 효과를 기대할 수 없는 문제점이 있었다.Commonly known whitening ingredients include substances that inhibit tyrosinase enzyme activity, such as kojic acid or arbutin, hydroquinone, vitamin C or derivatives thereof, and various plant extracts. They can brighten the skin tone and achieve skin whitening by inhibiting the synthesis of melanin, or improve skin hyperpigmentation such as spots and freckles caused by UV rays, hormones, or genetic factors. However, they have a problem in that the amount of use is limited due to safety issues such as irritation and redness when applied to the skin, or the actual effect cannot be expected because the effect is insignificant.
이에, 본 발명의 발명자들은 천연원료를 사용하여 인체에 부작용과 독성이 없으면서도, 피부 미백용 화장품 또는 의약외품 조성물 등으로 활용 가치가 높은 물질을 개발하고자 예의 노력한 결과, 상백피 추출물을 베이스로 글루타치온 및 마키베리 추출물을 유효성분으로 포함하는 조성물이 피부 미백뿐만 아니라 피부 트러블 개선, 보습 및 주름 개선에도 우수한 효과가 있음을 발견하여 본 발명을 완성하였다.Accordingly, the inventors of the present invention made diligent efforts to develop a substance with high utility value as a skin whitening cosmetic or quasi-drug composition, while having no side effects and toxicity to the human body using natural raw materials. The present invention was completed by discovering that a composition containing a berry extract as an active ingredient has excellent effects not only on skin whitening, but also on improving skin troubles, moisturizing and wrinkle improvement.
본 발명의 하나의 목적은 글루타치온, 마키베리 추출물 및 상백피 추출물을 유효성분으로 포함하는, 피부 미백용, 피부 트러블 개선용, 피부 보습용, 피부 주름 개선용 화장료 조성물을 제공하는 것이다.One object of the present invention is to provide a cosmetic composition for skin whitening, skin trouble improvement, skin moisturizing, and skin wrinkle improvement, comprising glutathione, macchiberry extract, and sangbaek skin extract as active ingredients.
본 발명의 다른 하나의 목적은 글루타치온, 마키베리 추출물 및 상백피 추출물을 유효성분으로 포함하는, 피부 미백용, 피부 트러블 개선용, 피부 보습용, 피부 주름 개선용 의약외품 조성물을 제공하는 것이다.Another object of the present invention is to provide a quasi-drug composition for skin whitening, skin trouble improvement, skin moisturizing, and skin wrinkle improvement, comprising glutathione, macchiberry extract and sangbaek skin extract as active ingredients.
이를 구체적으로 설명하면 다음과 같다. 한편, 본 출원에서 개시된 각각의 설명 및 실시형태는 각각의 다른 설명 및 실시 형태에도 적용될 수 있다. 즉, 본 출원에서 개시된 다양한 요소들의 모든 조합이 본 출원의 범주에 속한다. 또한, 하기 기술된 구체적인 서술에 의하여 본 출원의 범주가 제한된다고 볼 수 없다.This will be described in detail as follows. Meanwhile, each description and embodiment disclosed in the present application may be applied to each other description and embodiment. That is, all combinations of the various elements disclosed in the present application fall within the scope of the present application. In addition, it cannot be seen that the scope of the present application is limited by the detailed description described below.
상기 목적을 달성하기 위한 본 발명의 하나의 양태는 글루타치온, 마키베리 추출물 및 상백피 추출물을 유효성분으로 포함하는, 화장료 조성물을 제공한다. One aspect of the present invention for achieving the above object provides a cosmetic composition comprising glutathione, maquiberry extract and sangbaekpi extract as active ingredients.
본 발명의 상기 조성물은 피부 미백뿐 아니라 피부 트러블 개선, 피부 보습 또는 피부 주름 개선 효능이 우수하여 화장품으로서의 활용도가 높으며, 특히 피부 미백용 화장품으로서 현저히 우수한 효과를 나타낼 수 있다. The composition of the present invention is excellent in skin whitening as well as skin trouble improvement, skin moisturizing or skin wrinkle improvement effects, so it has high utility as a cosmetic, and in particular, it can exhibit a remarkably excellent effect as a skin whitening cosmetic.
본 발명에서 용어 "상백피(桑白皮)"는 뽕나무과의 뽕나무(Morus alba L.) 또는 동속 식물의 뿌리껍질로 만든 약재를 의미하는 것으로, 한방에서는 천식과 혈압 강하에 효과가 있으며, 이뇨 작용이 있는 것으로 알려져 있다.In the present invention, the term "sangbaekpi (桑白皮)" refers to a drug made from the root bark of Morus alba L. or a plant belonging to the Morus family. It is known that there is
본 발명에서 용어 "마키베리(Maqui berry, Aristotelia chilensis)"는 칠레 남부 다우림 지역을 원산지로 하는 괭이밥목 담팔수과 상록활엽수, 또는 그 열매를 의미하는 것으로, 항산화 물질인 안토시아닌과 폴리페놀 성분이 풍부하다. 전통적으로는 관절염, 고지혈증, 당뇨 및 심장질환 등에 효능이 있는 것으로 알려져 있다. 본 발명에서 마키베리는 상업적으로 판매되는 것을 구입하거나, 자연에서 채취 또는 재배된 것을 제한없이 사용할 수 있으며, 꽃, 잎, 열매, 씨앗, 뿌리 또는 줄기 등 부위에 제한없이 사용될 수 있다.In the present invention, the term "Maqui berry ( Aristotelia chilensis )" refers to an evergreen broadleaf tree of the Oxae family, or its fruit, native to the rain forest region of southern Chile, and is rich in antioxidants anthocyanins and polyphenols. Traditionally, it is known to be effective in arthritis, hyperlipidemia, diabetes and heart disease. In the present invention, maki berry can be purchased commercially, or harvested or cultivated in nature without limitation, and can be used without limitation in parts such as flowers, leaves, fruits, seeds, roots or stems.
본 발명에서 용어 "추출물"은 상기 상백피, 마키베리 등의 추출처리에 의하여 얻어지는 추출액, 상기 추출액의 희석액이나 농축액, 상기 추출액을 건조하여 얻어지는 건조물, 상기 추출액의 조정제물이나 정제물, 또는 이들의 혼합물 등, 추출액 자체 및 추출액을 이용하여 형성 가능한 모든 제형의 추출물을 포함한다. 본 발명의 상기 추출물은 천연, 잡종, 변종 식물로부터 제한없이 추출될 수 있고, 식물 조직 배양물로부터도 추출이 가능하다. In the present invention, the term "extract" refers to an extract obtained by extraction treatment of the sagebrush, maquiberry, etc., a diluted or concentrated solution of the extract, a dried product obtained by drying the extract, a prepared or purified product of the extract, or a mixture thereof and the like, including extracts of all formulations that can be formed using the extract itself and the extract. The extract of the present invention may be extracted without limitation from natural, hybrid, or variegated plants, and may also be extracted from plant tissue culture.
본 발명에 있어서 상기 추출물을 추출하는 방법은 특별히 제한되지 아니하며, 당해 기술분야에서 통상적으로 사용하는 방법에 따라 추출할 수 있다. 상기 추출 방법의 비제한적인 예로는, 열수추출법, 초음파 추출법, 여과법, 환류 추출법 등을 들 수 있으며, 이들은 단독으로 수행되거나 2 종 이상의 방법을 병용하여 수행될 수 있다.The method of extracting the extract in the present invention is not particularly limited, and may be extracted according to a method commonly used in the art. Non-limiting examples of the extraction method include hot water extraction, ultrasonic extraction, filtration, reflux extraction, and the like, and these may be performed alone or in combination of two or more methods.
본 발명에서 마키베리, 상백피 등을 추출하는데 사용되는 추출용매의 종류는 특별히 제한되지 아니하며, 당해 기술 분야에서 공지된 임의의 용매를 사용할 수 있다. 상기 추출 용매의 비제한적인 예로는 물; 메탄올, 에탄올, 프로필알코올, 부틸알코올 등의 C1 내지 C4의 저급 알코올; 글리세린, 부틸렌글리콜, 프로필렌글리콜 등의 다가 알코올; 및 메틸아세테이트, 에틸아세테이트, 아세톤, 벤젠, 헥산, 디에틸에테르, 디클로로메탄 등의 탄화수소계 용매; 또는 이들의 혼합물을 사용할 수 있으며, 바람직하게, 물, 저급알코올, 1,3-부틸렌글리콜, 에틸아세테이트를 단독으로 사용하거나 2종 이상 혼합하여 사용할 수 있다.In the present invention, the type of the extraction solvent used for extracting maquiberry, sangbaekpi, etc. is not particularly limited, and any solvent known in the art may be used. Non-limiting examples of the extraction solvent include water; C1-C4 lower alcohols, such as methanol, ethanol, propyl alcohol, and butyl alcohol; polyhydric alcohols such as glycerin, butylene glycol and propylene glycol; and hydrocarbon solvents such as methyl acetate, ethyl acetate, acetone, benzene, hexane, diethyl ether, and dichloromethane; Alternatively, a mixture thereof may be used, and preferably, water, lower alcohol, 1,3-butylene glycol, and ethyl acetate may be used alone or in a mixture of two or more.
본 발명에서 상백피, 마키베리 등을 추출하는 용매로 바람직하게는 물 또는 에탄올을 사용할 수 있다. 상기 용매를 사용하여 상백피, 마키베리 등을 1회 이상 추출하여 용매 추출물을 제조할 수 있으며, 상기 용매 추출물을 감압 증류한 후 동결건조 또는 분무 건조하여 얻은 건조 추출물을 제조할 수 있다. In the present invention, preferably water or ethanol may be used as a solvent for extracting sangbaekpi, maquiberry, and the like. A solvent extract may be prepared by extracting sangbaekpi, maquiberry, etc. one or more times using the solvent, and a dry extract obtained by distilling the solvent extract under reduced pressure and then freeze-drying or spray-drying may be prepared.
본 발명에서 열수 추출 또는 냉침 추출한 추출물은 부유하는 고체 입자를 제거하기 위해 여과, 예를 들어 나일론 등을 이용해 입자를 걸러내거나 냉동여과법 등을 이용해 여과한 후, 그대로 사용하거나 이를 동결건조, 열풍건조, 분무건조 등을 이용해 건조시켜 사용할 수 있다. In the present invention, the extract extracted with hot water or chilled extract is filtered to remove floating solid particles, for example, using nylon or the like to filter the particles, or after filtration using a freeze filtration method, etc. It can be used by drying it using spray drying or the like.
본 발명에서 용어 "분획물"은 다양한 구성 성분들을 포함하는 혼합물로부터 특정 성분 또는 특정 성분 그룹을 분리하기 위하여 분획을 수행하여 얻어진 결과물을 의미한다. 본 발명에서 상기 분획물을 얻는 분획 방법은 특별히 제한되지 아니하며, 당해 기술 분야에서 통상적으로 사용하는 방법에 따라 수행될 수 있다. 상기 분획 방법의 비제한적인 예로는 상백피, 마키베리 등을 추출하여 얻은 추출물에 소정의 용매를 처리하여 상기 추출물로부터 분획물을 얻는 방법을 들 수 있다.In the present invention, the term "fraction" refers to a result obtained by performing fractionation in order to separate a specific component or a specific component group from a mixture containing various components. The fractionation method for obtaining the fraction in the present invention is not particularly limited, and may be performed according to a method commonly used in the art. Non-limiting examples of the fractionation method include a method of obtaining a fraction from the extract by treating an extract obtained by extracting sangbaekpi, macchiberry, etc. with a predetermined solvent.
본 발명에서 상기 분획물을 얻는 데에 사용되는 용매의 종류는 특별히 제한되지 아니하며, 당해 기술 분야에서 공지된 임의의 용매를 사용할 수 있다. 상기 분획 용매의 비제한적인 예로는 물, 알코올 등의 극성 용매; 헥산(Hexane), 에틸아세테이트(Ethyl acetate), 클로로포름(Chloroform), 디클로로메탄(Dichloromethane) 등의 비극성 용매 등을 들 수 있다. 이들은 단독으로 사용되거나 2 종 이상 혼합하여 사용될 수 있다. 상기 분획 용매 중 알코올을 사용하는 경우에는 구체적으로는 C1 내지 C4의 저급 알코올을 사용할 수 있다.The kind of solvent used to obtain the fraction in the present invention is not particularly limited, and any solvent known in the art may be used. Non-limiting examples of the fractionation solvent include polar solvents such as water and alcohol; and non-polar solvents such as hexane, ethyl acetate, chloroform, and dichloromethane. These may be used alone or in combination of two or more. In the case of using alcohol among the fractionation solvents, specifically C1 to C4 lower alcohols may be used.
본 발명에서 용어 "글루타치온(glutathione)"은 화학식 C10H17N3O6S의 화학식을 갖는 분자량 약 307.3235 g/mol의 수용성·결정성의 펩티드 화합물로, 글루탐산(glutamate), 시스테인(cysteine) 및 글라이신(glycine) 세 개의 펩타이드로 구성되어 있으며, 생체 내의 산화환원반응에 중요한 역할을 하는 것으로 알려져 있다. In the present invention, the term "glutathione" is a water-soluble and crystalline peptide compound having a molecular weight of about 307.3235 g/mol having a formula of the formula C 10 H 17 N 3 O 6 S, glutamate, cysteine, and It is composed of three peptides of glycine and is known to play an important role in redox reactions in vivo.
상기 글루타치온은 생체 내에 존재하는 항산화제로서 아스코르빈산(비타민 C), 토코페롤(비타민 E) 등과 같은 생체 내 항산화제와 가역적으로 반응하여 생체 내 라디칼을 효과적으로 제거할 수 있다.The glutathione as an antioxidant present in the living body can effectively remove radicals in the living body by reversibly reacting with the in vivo antioxidants such as ascorbic acid (vitamin C) and tocopherol (vitamin E).
상기 글루타치온은 상기 라디칼 제거와 관련된 생체 시스템에서 최종 라디칼 수용체로서 매우 중요한 역할을 수행할 수 있다.The glutathione may play a very important role as a final radical receptor in a biological system related to the radical removal.
본 발명의 다른 하나의 양태는 글루타치온, 마키베리 추출물 및 상백피 추출물을 유효성분으로 포함하는 피부 미백용 화장료 조성물을 제공한다.Another aspect of the present invention provides a cosmetic composition for skin whitening comprising glutathione, maquiberry extract, and sangbaekpi extract as active ingredients.
본 발명에서 용어 "피부 미백"은 멜라닌 색소의 합성을 저해함으로써 피부 톤을 밝게 할 뿐만 아니라, 자외선, 호르몬, 스트레스 또는 유전적 요인 등에 기인한 기미나 주근깨 등 피부 과색소 침착을 개선하는 것을 모두 의미한다.In the present invention, the term "skin whitening" means not only to brighten skin tone by inhibiting the synthesis of melanin pigment, but also to improve skin hyperpigmentation such as spots or freckles caused by UV rays, hormones, stress, or genetic factors. do.
본 발명의 또 다른 하나의 양태는 글루타치온, 마키베리 추출물 및 상백피 추출물을 유효성분으로 포함하는 피부 트러블 개선용 화장료 조성물을 제공한다.Another aspect of the present invention provides a cosmetic composition for improving skin troubles comprising glutathione, maquiberry extract, and sangbaekpi extract as active ingredients.
본 발명에서 용어 "피부 트러블"은 대식세포에서의 과도한 일산화질소(NO) 생성으로 유발된 염증에 의해 발생할 수 있는 피부질환 또는 증상을 의미한다. 상기 피부 트러블은 염증과 관련된 피부질환이면 그 종류에 관계없이 모두 포함되며, 상기 염증과 관련된 피부질환 또는 증상의 비제한적인 예로는 피부발진, 여드름, 뾰루지, 아토피 피부염, 건선, 홍반성 질환, 피부 소양증, 지루성 습진 등이 있으나 이에 제한되는 것은 아니다. 이에, 본 발명의 용어 "트러블 개선"은 피부에 상기 트러블이 생성되는 것을 억제 또는 저해하거나, 이미 생성된 트러블을 완화시키는 것을 의미하며, 보다 구체적으로는 피부 상의 염증을 생성을 억제하거나 이미 생성된 염증을 완화, 개선시키는 "항염증" 활성을 의미할 수 있다.As used herein, the term “skin trouble” refers to a skin disease or symptom that may be caused by inflammation caused by excessive nitric oxide (NO) production in macrophages. The skin trouble is included regardless of the type of skin disease related to inflammation, non-limiting examples of skin diseases or symptoms related to inflammation include skin rash, acne, pimples, atopic dermatitis, psoriasis, erythematosus, skin Pruritus, seborrheic eczema, etc., but are not limited thereto. Accordingly, the term "trouble improvement" of the present invention means to inhibit or inhibit the generation of the trouble on the skin, or to alleviate the trouble already generated, and more specifically, inhibit the generation of inflammation on the skin, or It may refer to “anti-inflammatory” activity to relieve, ameliorate inflammation.
본 발명의 또 다른 하나의 양태는 글루타치온, 마키베리 추출물 및 상백피 추출물을 유효성분으로 포함하는 피부 보습용 화장료 조성물을 제공한다.Another aspect of the present invention provides a cosmetic composition for moisturizing the skin comprising glutathione, maquiberry extract, and sangbaekpi extract as active ingredients.
본 발명에서 용어 "피부 보습"은 피부에 수분감을 증가시켜주고, 촉촉한 상태를 유지시키는 것을 의미한다.In the present invention, the term "skin moisturizing" means to increase the feeling of moisture in the skin and to maintain a moist state.
본 발명의 또 다른 하나의 양태는 글루타치온, 마키베리 추출물 및 상백피 추출물을 유효성분으로 포함하는 피부 주름 개선용 화장료 조성물을 제공한다.Another aspect of the present invention provides a cosmetic composition for skin wrinkle improvement comprising glutathione, a macchiberry extract, and an epiphyllum extract as active ingredients.
본 발명에서 용어 "주름 개선"은 피부에 주름이 생성되는 것을 억제 또는 저해하거나, 이미 생성된 주름을 완화시키는 것을 의미하는 것으로, 엘라스틴(elastin)과 콜라겐(collagen)이 피부층에 충분히 존재하는 상태를 유지하여 피부 탄력을 증진시키는 것 또한 본 발명의 주름 개선에 포함될 수 있다.In the present invention, the term "wrinkle improvement" refers to inhibiting or inhibiting the generation of wrinkles on the skin, or alleviating the already generated wrinkles, in which elastin and collagen are sufficiently present in the skin layer. Maintaining and enhancing skin elasticity may also be included in the wrinkle improvement of the present invention.
본 발명에 따른 화장료 조성물은 상백피 추출물을 베이스로 하여 글루타치온 및 마키베리 추출물을 주요성분으로 포함할 수 있으며, 상기 상백피 추출물 및 주요성분은 화장료 조성물 전체 중량 대비 0.0001 내지 50 중량% 포함될 수 있으며, 바람직하게는 0.001 내지 10 중량%, 더욱 바람직하게는 0.01 내지 5 중량% 포함될 수 있다.The cosmetic composition according to the present invention may include glutathione and macchiberry extract as main components based on the epiphyllum extract, and the extract and the main component may include 0.0001 to 50% by weight based on the total weight of the cosmetic composition, preferably 0.001 to 10% by weight, more preferably 0.01 to 5% by weight may be included.
상기 추출물 및 주요성분의 함량이 0.0001 중량% 미만일 경우, 피부 미백, 피부 트러블 개선, 피부 보습 및/또는 피부 주름 개선 효과를 기대하기 어렵고, 50 중량%를 초과하는 경우, 증가하는 함유량만큼 뚜렷한 효과가 기대되지 않는다.When the content of the extract and the main component is less than 0.0001% by weight, it is difficult to expect skin whitening, skin trouble improvement, skin moisturizing and/or skin wrinkle improvement effects, and when it exceeds 50% by weight, a distinct effect as much as the increasing content is obtained not expected
바람직한 실시예에서 상기 화장료 조성물에 포함되는 글루타치온, 마키베리 추출물 및 상백피 추출물의 혼합비율은 중량비(w/w) 기준으로 1:1~3: 1~3으로 혼합될 수 있으며, 1:1:3의 중량비로 혼합되는 것이 가장 바람직하다.In a preferred embodiment, the mixing ratio of glutathione, maquiberry extract, and sagebrush extract included in the cosmetic composition is 1:1 to 3: 1 to 3 based on weight ratio (w/w), and 1:1:3 It is most preferable to mix in a weight ratio of
상기 성분들은 상기 함량 범위일 때, 피부 자극이 적으면서도 피부 미백, 피부 트러블 개선, 피부 보습 및/또는 피부 주름 개선 효과를 가져올 수 있으며, 특히, 글루타치온, 마키베리 추출물 및 상백피 추출물이 1:1:3의 비율로 혼합된 화장료 조성물이 가장 우수한 조합임을 확인할 수 있었다.When the above ingredients are within the above content range, skin whitening, skin trouble improvement, skin moisturizing and/or skin wrinkle improvement effects can be brought about with little skin irritation. It was confirmed that the cosmetic composition mixed in a ratio of 3 was the most excellent combination.
또한, 상기 화장료 조성물은 유연화장수, 수렴화장수, 영양화장수, 영양크림, 마사지크림, 에센스, 팩, 피부접착용 패치, 피부접착용 겔, 파우더, 연고, 페이스트, 젤, 서스펜션, 에멀젼, 스프레이, 미용액 또는 캡슐로 제형화되는 것일 수 있으며, 이에 특별히 제한되지 않는다.In addition, the cosmetic composition is a softening lotion, astringent lotion, nourishing lotion, nourishing cream, massage cream, essence, pack, skin adhesive patch, skin adhesive gel, powder, ointment, paste, gel, suspension, emulsion, spray, serum Or it may be formulated as a capsule, but is not particularly limited thereto.
본 발명의 화장료 조성물은 일반 피부 화장료에 배합되는 화장품학적으로 허용 가능한 담체를 1종 이상 추가로 포함할 수 있으며, 통상의 성분으로 예를 들면 유분, 물, 계면활성제, 보습제, 저급 알콜, 증점제, 킬레이트제, 색소, 방부제, 향료 등을 적절히 배합할 수 있으며, 이에 특별히 제한되는 것은 아니다. 본 발명의 화장료 조성물에 포함되는 화장품학적으로 허용 가능한 담체는 제형에 따라 다양하다. The cosmetic composition of the present invention may further include one or more cosmetically acceptable carriers to be formulated in general skin cosmetics, and conventional ingredients include, for example, oil, water, surfactant, humectant, lower alcohol, thickener, A chelating agent, a colorant, a preservative, a fragrance, etc. may be appropriately blended, but is not particularly limited thereto. The cosmetically acceptable carrier included in the cosmetic composition of the present invention varies depending on the formulation.
본 발명의 제형이 용액 또는 유탁액인 경우에는 담체 성분으로서 용매, 용해화제 또는 유탁화제가 이용되고, 예컨대 물, 에탄올, 이소프로판올, 에틸 카보네이트, 에틸 아세테이트, 벤질 알코올, 벤질 벤조에이트, 프로필렌글리콜, 1,3-부틸글리콜 오일, 글리세롤 지방족 에스테르, 폴리에틸렌 글리콜 또는 소르비탄의 지방산에스테르가 있다.When the formulation of the present invention is a solution or emulsion, a solvent, solubilizer or emulsifier is used as a carrier component, for example, water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene glycol, 1 ,3-butylglycol oil, glycerol fatty ester, polyethylene glycol or fatty acid ester of sorbitan.
본 발명의 제형이 현탁액인 경우에는 담체 성분으로서 물, 에탄올 또는 프로필렌 글리콜과 같은 액상의 희석제, 에톡실화 이소스테아릴 알코올, 폴리옥시에틸렌 소르비톨 에스테르 및 폴리옥시에틸렌 소르비탄 에스테르와 같은 현탁제, 미소결정성 셀룰로오스, 알루미늄 메타히드록시드, 벤토나이트, 또는 트라칸트 등이 이용될 수 있다.When the formulation of the present invention is a suspension, as a carrier component, a liquid diluent such as water, ethanol or propylene glycol, a suspending agent such as ethoxylated isostearyl alcohol, polyoxyethylene sorbitol ester and polyoxyethylene sorbitan ester, microcrystals Adult cellulose, aluminum metahydroxide, bentonite, or tracanth may be used.
본 발명의 제형이 연고, 페이스트, 크림 또는 겔인 경우에는 담체 성분으로서 동물성유, 식물성유, 왁스, 파라핀, 전분, 트라칸트, 셀룰로오스 유도체, 폴리에틸렌 글리콜, 실리콘, 벤토나이트, 실리카, 탈크 또는 산화아연 등이 이용될 수 있다.When the formulation of the present invention is an ointment, paste, cream or gel, animal oil, vegetable oil, wax, paraffin, starch, tracanth, cellulose derivative, polyethylene glycol, silicone, bentonite, silica, talc or zinc oxide as a carrier component can be used
본 발명의 제형이 파우더 또는 스프레이인 경우에는 담체 성분으로서 락토스, 탈크, 실리카, 알루미늄 히드록시드, 칼슘 실리케이트 또는 폴리아미드 파우더가 이용될 수 있고, 특히 스프레이인 경우에는 추가적으로 클로로플루오로히드로카본, 프로판/부탄 또는 디메틸 에테르와 같은 추진체를 포함할 수 있다.When the formulation of the present invention is a powder or a spray, lactose, talc, silica, aluminum hydroxide, calcium silicate or polyamide powder may be used as a carrier component. In particular, in the case of a spray, additional chlorofluorohydrocarbon, propane /may contain propellants such as butane or dimethyl ether.
본 발명의 제형이 계면-활성제 함유 클린징인 경우에는 담체 성분으로서 지방족 알코올 설페이트, 지방족 알코올 에테르 설페이트, 설포숙신산 모노에스테르, 이세티오네이트, 이미다졸리늄 유도체, 메틸타우레이트, 사르코시네이트, 지방산 아미드 에테르 설페이트, 알킬아미도베타인, 지방족 알코올, 지방산 글리세리드, 지방산 디에탄올아미드, 식물성유, 라놀린 유도체 또는 에톡실화 글리세롤 지방산에스테르 등이 이용될 수 있다. 또한, 상기 화장료 조성물에 포함되는 성분들은 피부 과학 분야에서 일반적으로 사용되는 양으로 포함될 수 있다.When the formulation of the present invention is a surfactant-containing cleansing agent, aliphatic alcohol sulfate, aliphatic alcohol ether sulfate, sulfosuccinic acid monoester, isethionate, imidazolinium derivative, methyl taurate, sarcosinate, fatty acid amide as carrier components Ether sulfate, alkylamidobetaine, fatty alcohol, fatty acid glyceride, fatty acid diethanolamide, vegetable oil, lanolin derivative or ethoxylated glycerol fatty acid ester may be used. In addition, the ingredients included in the cosmetic composition may be included in an amount generally used in the field of dermatology.
또한, 본 발명의 화장료 조성물은 상기 상백피 추출물 및 주요성분 이외에 통상적으로 이용되는 보조제, 예컨대 친수성 또는 친지성 겔화제, 친수성 또는 친지성 활성제, 보존제, 항산화제, 용매, 방향제, 충전제, 차단제, 안료, 흡취제 및 염료 등을 포함할 수 있다.In addition, the cosmetic composition of the present invention may contain, in addition to the above extract and main ingredients, commonly used auxiliary agents, such as hydrophilic or lipophilic gelling agents, hydrophilic or lipophilic active agents, preservatives, antioxidants, solvents, fragrances, fillers, blockers, pigments, It may include odorants and dyes, and the like.
상기 목적을 달성하기 위한 본 발명의 또 다른 하나의 양태는 글루타치온, 마키베리 추출물 및 상백피 추출물을 유효성분으로 포함하는, 의약외품 조성물을 제공한다. 상기 글루타치온, 마키베리, 상백피, 추출물, 분획물, 피부 미백, 피부 트러블, 트러블 개선, 항염증, 피부 보습 및 주름 개선 등 용어는 전술한 바와 같다.Another aspect of the present invention for achieving the above object provides a quasi-drug composition comprising glutathione, maquiberry extract and sangbaekpi extract as active ingredients. The terms such as glutathione, maquiberry, sagebrush, extract, fraction, skin whitening, skin trouble, trouble improvement, anti-inflammatory, skin moisturizing and wrinkle improvement are the same as described above.
본 발명에 따른 의약외품 조성물은 상백피 추출물을 베이스로 하여 글루타치온 및 마키베리 추출물을 주요성분으로 포함할 수 있으며, 상기 상백피 추출물 및 주요성분은 의약외품 조성물 전체 중량 대비 0.0001 내지 50 중량% 포함될 수 있으며, 바람직하게는 0.001 내지 10 중량%, 더욱 바람직하게는 0.01 내지 5 중량% 포함될 수 있다.The quasi-drug composition according to the present invention may include glutathione and macchiberry extract as main components based on the quasi-drug extract, and the quasi-drug extract and the main component may be included in an amount of 0.0001 to 50% by weight based on the total weight of the quasi-drug composition, preferably 0.001 to 10% by weight, more preferably 0.01 to 5% by weight may be included.
상기 추출물 및 주요성분의 함량이 0.0001 중량% 미만일 경우, 피부 미백, 피부 트러블 개선, 피부 보습 및/또는 피부 주름 개선 효과를 기대하기 어렵고, 50 중량%를 초과하는 경우, 증가하는 함유량만큼 뚜렷한 효과가 기대되지 않는다.When the content of the extract and the main component is less than 0.0001% by weight, it is difficult to expect skin whitening, skin trouble improvement, skin moisturizing and/or skin wrinkle improvement effects, and when it exceeds 50% by weight, a distinct effect as much as the increasing content is obtained not expected
바람직한 실시예에서 상기 의약외품 조성물에 포함되는 글루타치온, 마키베리 추출물 및 상백피 추출물의 혼합비율은 중량비(w/w) 기준으로 1:1~3: 1~3으로 혼합될 수 있으며, 1:1:3의 중량비로 혼합되는 것이 가장 바람직하다.In a preferred embodiment, the mixing ratio of glutathione, macchiberry extract, and sagebrush extract included in the quasi-drug composition is 1:1 to 3: 1 to 3 based on weight ratio (w/w), 1:1:3 It is most preferable to mix in a weight ratio of
상기 성분들은 상기 함량 범위일 때, 피부 자극이 적으면서도 피부 미백, 피부 트러블 개선, 피부 보습 및/또는 피부 주름 개선 효과를 가져올 수 있으며, 특히, 글루타치온, 마키베리 추출물 및 상백피 추출물이 1:1:3의 비율로 혼합된 의약외품 조성물이 가장 우수한 조합임을 확인할 수 있었다.When the above ingredients are within the above content range, skin whitening, skin trouble improvement, skin moisturizing and/or skin wrinkle improvement effects can be brought about with little skin irritation. It was confirmed that the quasi-drug composition mixed in a ratio of 3 was the best combination.
본 발명의 의약외품 조성물에는 상기 성분 외에 필요에 따라 약학적으로 허용 가능한 담체, 부형제 또는 희석제를 더욱 포함할 수 있다. 상기 약학적으로 허용 가능한 담체, 부형제 또는 희석제는 본 발명의 효과를 해하지 않는 한 제한되지 않으며, 예를 들어 충진제, 증량제, 결합제, 습윤제, 붕해제, 계면활성제, 윤활제, 감미제, 방향제, 보존제 등을 포함할 수 있다.The quasi-drug composition of the present invention may further include a pharmaceutically acceptable carrier, excipient or diluent if necessary in addition to the above components. The pharmaceutically acceptable carrier, excipient or diluent is not limited as long as it does not impair the effects of the present invention, and includes, for example, fillers, extenders, binders, wetting agents, disintegrants, surfactants, lubricants, sweeteners, fragrances, preservatives, etc. may include
본 발명의 약학적으로 허용 가능한 담체, 부형제 또는 희석제의 대표적인 예로는, 락토즈, 덱스트로스, 슈크로스, 솔비톨, 만니톨, 자일리톨, 말티톨, 전분, 젤라틴, 글리세린, 아카시아 고무, 알지네이트, 칼슘포스페이트, 칼슘카보네이트, 칼슘실리케이트, 셀룰로즈, 메틸 셀룰로즈, 미정질 셀룰로즈, 폴리비닐 피롤리돈, 물, 메틸히드록시벤조에이트, 프로필히드록시벤조에이트, 탈크, 마그네슘 스테아레이트, 광물유, 프로필렌글리콜, 폴리에틸렌글리콜, 식물성 오일, 주사가능한 에스테르, 위텝솔, 마크로골, 트윈 61, 카카오지, 라우리지 등을 들 수 있다.Representative examples of the pharmaceutically acceptable carrier, excipient or diluent of the present invention include lactose, dextrose, sucrose, sorbitol, mannitol, xylitol, maltitol, starch, gelatin, glycerin, acacia gum, alginate, calcium phosphate, calcium Carbonate, calcium silicate, cellulose, methyl cellulose, microcrystalline cellulose, polyvinyl pyrrolidone, water, methylhydroxybenzoate, propylhydroxybenzoate, talc, magnesium stearate, mineral oil, propylene glycol, polyethylene glycol, vegetable oil , injectable esters, Witepsol, Macrogol, Tween 61, cacao butter, laurage, and the like.
또한, 본 발명의 조성물을 의약외품으로 사용하는 경우, 추가로 동일 또는 유사한 기능을 나타내는 유효성분을 1종 이상 함유할 수 있다. 예컨대, 공지의 탄력 증진, 주름 개선, 보습, 또는 항염증 성분을 포함할 수 있다. 추가적인 탄력 증진, 주름 개선, 보습, 또는 항염증 성분을 포함하게 되면 본 발명의 조성물의 탄력 증진, 주름 개선, 보습, 또는 피부 트러블 개선 효과는 더욱 증가될 수 있을 것이다. 상기 성분 추가 시에는 복합 사용에 따른 피부 안전성, 제형화의 용이성, 유효성분들의 안정성을 고려할 수 있다. 상기 의약외품 조성물은 당업계에 공지된 당업계에 공지된 피부 탄력, 주름 개선 또는 보습 성분으로서, 레티노산, TGF, 동물 태반 유래의 단백질, 베툴린산 및 클로렐라 추출물; 당업계에 공지된 항염증 성분으로서, 비스테로이드계로 플루페남산, 이부프로펜, 벤지다민, 인도메타신, 프레드니솔론, 덱사메타손, 알란토인, 아즈엔, 하이드로코티손; 및 이들의 유도체와 각종 식물 추출물로 구성되는 군으로부터 선택되는 1종 이상의 성분을 추가로 포함할 수 있다. 추가 성분은 전체 조성물 중량에 대하여 0.0001 내지 10 중량%(w/w)로 포함될 수 있을 것이며, 상기 함량 범위는 피부 안전성 및 제형화 시의 용이성 등에 따라 조절될 수 있다.In addition, when the composition of the present invention is used as a quasi-drug, it may further contain one or more active ingredients exhibiting the same or similar function. For example, it may include known elasticity enhancement, wrinkle improvement, moisturizing, or anti-inflammatory ingredients. When an additional elasticity enhancement, wrinkle improvement, moisturizing, or anti-inflammatory component is included, the elasticity enhancement, wrinkle improvement, moisturizing, or skin trouble improvement effect of the composition of the present invention may be further increased. When adding the above ingredients, skin safety according to combined use, ease of formulation, and stability of active ingredients can be considered. The quasi-drug composition is known in the art as a skin elasticity, wrinkle improvement or moisturizing component known in the art, retinoic acid, TGF, animal placenta-derived protein, betulinic acid and chlorella extract; As anti-inflammatory ingredients known in the art, non-steroidal flufenamic acid, ibuprofen, benzidamine, indomethacin, prednisolone, dexamethasone, allantoin, azene, hydrocortisone; and one or more components selected from the group consisting of derivatives thereof and various plant extracts. Additional components may be included in an amount of 0.0001 to 10% by weight (w/w) based on the total weight of the composition, and the content range may be adjusted according to skin safety and ease of formulation.
본 발명의 의약외품 조성물은 소독 청결제, 샤워폼, 연고액, 물티슈, 코팅제 등을 예시할 수 있으나 이에 특별히 제한되는 것이 아니며, 의약외품의 제제화 방법, 용량, 이용방법, 구성성분 등은 기술분야에 공지된 통상의 기술로부터 적절히 선택될 수 있다.The quasi-drug composition of the present invention may be exemplified by a disinfectant cleaner, shower foam, ointment, wet tissue, coating agent, and the like, but is not particularly limited thereto. It may be appropriately selected from conventional techniques.
또한, 상백피 추출물을 베이스로 하여 글루타치온 및 마키베리 추출물을 주요성분으로 포함하는 본 발명의 조성물은 이를 개체의 피부에 도포하는 단계를 포함하는, 피부 미백, 트러블 개선, 피부 보습, 및/또는 주름 개선 방법 등에 사용될 수 있다. 상기 개체는 쥐, 가축, 인간 등을 포함하는 포유동물을 제한없이 포함한다.In addition, the composition of the present invention comprising glutathione and macchiberry extract as a main component based on the epiphyllum extract, skin whitening, trouble improvement, skin moisturizing, and/or wrinkle improvement, including the step of applying it to the skin of an individual method and the like. The subject includes, without limitation, mammals including rats, livestock, humans, and the like.
상기 목적을 달성하기 위한 본 발명의 또 다른 하나의 양태는 글루타치온, 마키베리 추출물 및 상백피 추출물을 유효성분으로 포함하는, 식품 조성물을 제공한다. Another aspect of the present invention for achieving the above object provides a food composition comprising glutathione, maquiberry extract and sangbaekpi extract as active ingredients.
본 발명의 상기 조성물은, 피부 미백뿐 아니라 피부 트러블 개선, 피부 보습 또는 피부 주름 개선 효능이 우수하여 건강 기능성 식품 조성물로서의 활용도가 높으며, 특히 이너뷰티 푸드로서 현저히 우수한 효과를 나타낼 수 있다. The composition of the present invention is excellent in skin whitening as well as skin trouble improvement, skin moisturizing or skin wrinkle improvement effects, so it has high utility as a health functional food composition, and can exhibit a remarkably excellent effect as an inner beauty food.
본 발명에 따른 식품 조성물은 상백피 추출물을 베이스로 하여 글루타치온 및 마키베리 추출물을 주요성분으로 포함할 수 있으며, 상기 상백피 추출물 및 주요성분은 식품 조성물 전체 중량 대비 0.0001 내지 50 중량% 포함될 수 있으며, 바람직하게는 0.001 내지 10 중량%, 더욱 바람직하게는 0.01 내지 5 중량% 포함될 수 있다.The food composition according to the present invention may include glutathione and macchiberry extract as main components based on the sagebrush extract and the main component may include 0.0001 to 50% by weight based on the total weight of the food composition, preferably 0.001 to 10% by weight, more preferably 0.01 to 5% by weight may be included.
상기 추출물 및 주요성분의 함량이 0.0001 중량% 미만일 경우, 피부 미백, 피부 트러블 개선, 피부 보습 및/또는 피부 주름 개선 효과를 기대하기 어렵고, 50 중량%를 초과하는 경우, 증가하는 함유량만큼 뚜렷한 효과가 기대되지 않는다.When the content of the extract and the main component is less than 0.0001% by weight, it is difficult to expect skin whitening, skin trouble improvement, skin moisturizing and/or skin wrinkle improvement effects, and when it exceeds 50% by weight, a distinct effect as much as the increasing content is obtained not expected
바람직한 실시예에서 상기 식품 조성물에 포함되는 글루타치온, 마키베리 추출물 및 상백피 추출물의 혼합비율은 중량비(w/w) 기준으로 1:1~3:1~3으로 혼합될 수 있으며, 1:1:3의 중량비로 혼합되는 것이 가장 바람직하다.In a preferred embodiment, the mixing ratio of glutathione, maquiberry extract, and sagebrush extract included in the food composition may be 1:1 to 3:1 to 3 based on weight ratio (w/w), 1:1:3 It is most preferable to mix in a weight ratio of
상기 성분들은 상기 함량 범위일 때, 피부 자극이 적으면서도 피부 미백, 피부 트러블 개선, 피부 보습 및/또는 피부 주름 개선 효과를 가져올 수 있으며, 특히, 글루타치온, 마키베리 추출물 및 상백피 추출물이 1:1:3의 비율로 혼합된 식품 조성물이 가장 우수한 조합임을 확인할 수 있었다.When the above ingredients are within the above content range, skin whitening, skin trouble improvement, skin moisturizing and/or skin wrinkle improvement effects can be brought about with little skin irritation. It was confirmed that the food composition mixed in a ratio of 3 was the best combination.
본 발명의 식품 조성물은 상기 상백피 추출물 및 주요성분 외에 식품학적으로 허용 가능한 식품보조첨가제를 포함할 수 있다. 상기 "식품보조첨가제"란 식품에 보조적으로 첨가될 수 있는 구성 요소를 의미하며, 각 제형의 건강 기능성 식품을 제조하는데 첨가되는 것으로서 당업자가 적절히 선택하여 사용할 수 있다. 식품보조첨가제의 예로는 영양제, 비타민, 전해질, 합성 풍미제 및 천연 풍미제 등의 풍미제, 착색제 및 충진제, 펙트산 및 그의 염, 알긴산 및 그의 염, 유기산, 보호성 콜로이드 증점제, pH 조절제, 안정화제, 방부제, 글리세린, 알콜, 탄산음료에 사용되는 탄산화제 등이 포함되며, 이에 특별히 제한되는 것은 아니다.The food composition of the present invention may include a food-logically acceptable food supplement in addition to the extract and main ingredients of the sangbaekpi extract. The "food supplementary additive" refers to a component that can be supplementally added to food, and is added to prepare a health functional food of each formulation, and those skilled in the art can appropriately select and use it. Examples of food supplement additives include nutrients, vitamins, electrolytes, flavoring agents such as synthetic and natural flavoring agents, coloring agents and fillers, pectic acid and salts thereof, alginic acid and salts thereof, organic acids, protective colloidal thickeners, pH adjusting agents, stability It includes, but is not particularly limited to, an agent, a preservative, glycerin, alcohol, a carbonation agent used in carbonated beverages, and the like.
또한, 본 발명의 식품 조성물에는 건강 기능성 식품이 포함될 수 있다. 본 발명에서 용어 "건강기능식품"이란, 인체에 유용한 기능성을 가진 원료나 성분을 사용하여 정제, 캅셀, 분말, 과립, 액상 및 환 등의 형태로 제조 및 가공한 식품을 말한다. 여기서 "기능성"이라 함은 인체의 구조 및 기능에 대하여 영양소를 조절하거나 생리학적 작용 등과 같은 보건용도에 유용한 효과를 얻는 것을 의미한다. 본 발명의 건강기능식품은 당업계에서 통상적으로 사용되는 방법에 의하여 제조 가능하며, 상기 제조시에는 당업계에서 통상적으로 첨가하는 원료 및 성분을 첨가하여 제조할 수 있다. 또한 상기 건강기능식품의 제형 또한 건강기능식품으로 인정되는 제형이면 제한 없이 제조될 수 있다. 본 발명의 식품 조성물은 다양한 형태의 제형으로 제조될 수 있으며, 일반 약품과는 달리 식품을 원료로 하여 약품의 장기 복용 시 발생할 수 있는 부작용 등이 없는 장점이 있고, 휴대성이 뛰어나, 본 발명의 건강기능식품은 피부 미백, 피부 탄력 증진 또는 주름 개선, 피부 보습, 항산화 또는 피부 트러블 개선 효과를 증진시키기 위한 보조제로 섭취가 가능하다.In addition, the food composition of the present invention may include a health functional food. As used herein, the term "health functional food" refers to food manufactured and processed in the form of tablets, capsules, powders, granules, liquids, pills, etc. using raw materials or ingredients useful for the human body. Here, "functional" means to obtain useful effects for health purposes, such as regulating nutrients or physiological actions with respect to the structure and function of the human body. The health functional food of the present invention can be prepared by a method commonly used in the art, and during the manufacture, it can be prepared by adding raw materials and components commonly added in the art. In addition, the dosage form of the health functional food may be manufactured without limitation as long as it is a dosage form recognized as a health functional food. The food composition of the present invention can be prepared in various forms, and unlike general drugs, it has the advantage of not having side effects that may occur during long-term administration of the drug using food as a raw material, and has excellent portability, Health functional food can be taken as a supplement for skin whitening, skin elasticity enhancement or wrinkle improvement, skin moisturizing, antioxidant or skin trouble improvement effect.
본 발명의 건강 기능성 식품이 취할 수 있는 형태에는 제한이 없으며, 통상적인 의미의 식품을 모두 포함할 수 있고, 건강 기능 식품, 기능성 식품 등 당업계에 알려진 용어와 혼용될 수 있다. 아울러 본 발명의 건강 기능성 식품은 당업자의 선택에 따라 식품에 포함될 수 있는 적절한 기타 보조성분과 공지의 첨가제를 혼합하여 제조할 수 있다. 상기 건강 기능성 식품의 예로는 육류, 소세지, 빵, 쵸코렛, 캔디류, 스낵류, 과자류, 피자, 라면, 기타 면류, 껌류, 아이스크림류를 포함한 낙농제품, 각종 스프, 음료수, 차, 드링크제, 알콜 음료 및 비타민 복합제 등이 있으며, 본 발명에 따른 조성물을 주성분으로 하여 제조한 즙, 차, 젤리 및 주스 등을 첨가하여 제조할 수 있다.There is no limitation in the form that the health functional food of the present invention can take, and it may include any food in a conventional sense, and may be used interchangeably with terms known in the art, such as health functional food and functional food. In addition, the health functional food of the present invention can be prepared by mixing known additives with other suitable auxiliary ingredients that may be included in the food according to the selection of those skilled in the art. Examples of the health functional food include meat, sausage, bread, chocolate, candy, snacks, confectionery, pizza, ramen, other noodles, gums, dairy products including ice cream, various soups, beverages, tea, drinks, alcoholic beverages and vitamins There are complex agents, and it can be prepared by adding juice, tea, jelly and juice prepared using the composition according to the present invention as a main component.
상기 목적을 달성하기 위한 본 발명의 또 다른 하나의 양태는 상기 식품 조성물을 포함하는 건강 기능성 식품을 제공한다. 상기 글루타치온, 마키베리, 상백피, 추출물, 분획물, 피부 미백, 피부 트러블, 트러블 개선, 항염증, 피부 보습, 주름 개선 및 건강 기능성 식품 등 용어는 전술한 바와 같다.Another aspect of the present invention for achieving the above object provides a health functional food comprising the food composition. Terms such as glutathione, maquiberry, sagebrush, extract, fraction, skin whitening, skin trouble, trouble improvement, anti-inflammatory, skin moisturizing, wrinkle improvement and health functional food are the same as described above.
본 발명의 건강 기능성 식품은 이너뷰티 푸드인 것을 특징으로 하는 것일 수 있다. 본 발명에서 용어 "이너뷰티 푸드(inner beauty food) "는 먹는 화장품 또는 뷰티 푸드로도 불리우며, 피부 미용 및 건강에 좋은 성분을 몸속으로 흡수시켜 피부 체질을 건강하게 개선시키는 식품을 지칭하는 것으로, 피부 타입에 맞는 화장품을 고르듯 피부 컨디션과 라이프 스타일 등을 고려해 개개인에게 맞는 이너뷰티 푸드를 선택하여 섭취할 수 있다. 본 발명의 상기 건강 기능성 식품은 이너뷰티 푸드 형태로 섭취함으로써 더욱 우수한 피부 미백, 피부 트러블 개선, 피부 보습 및 주름 개선 효과를 나타내는 장점을 갖는다.The health functional food of the present invention may be characterized as an inner beauty food. In the present invention, the term "inner beauty food" is also called edible cosmetics or beauty food, and refers to food that improves skin constitution by absorbing ingredients good for skin beauty and health into the body. Just like choosing a cosmetic that suits your type, you can choose and consume inner beauty food that suits you, taking into account your skin condition and lifestyle. The health functional food of the present invention has the advantage of showing more excellent skin whitening, skin trouble improvement, skin moisturizing and wrinkle improvement effects by ingesting it in the form of inner beauty food.
본 발명의 글루타치온, 마키베리 추출물 및 상백피 추출물을 유효성분으로 포함하는 조성물은 피부 미백, 피부 트러블 개선, 피부 보습 또는 피부 주름 개선 효능이 우수하여 피부 미백용, 피부 트러블 개선용, 피부 보습용 또는 피부 주름 개선용 화장품으로서의 활용도가 높다. 또한 본 발명의 조성물은 의약외품 조성물로서 사용할 수 있다.The composition comprising glutathione, macchi berry extract, and sagebrush extract of the present invention as an active ingredient is excellent in skin whitening, skin trouble improvement, skin moisturizing or skin wrinkle improvement effects, so that it is used for skin whitening, skin trouble improvement, skin moisturizing or skin It has high utility as a cosmetic for wrinkle improvement. In addition, the composition of the present invention can be used as a quasi-drug composition.
도 1은 본 발명의 조성물이 갖는 멜라닌 생성 억제 효과를 나타내는 그래프이다.
도 2는 본 발명의 조성물이 갖는 NO 생성 억제 효과를 나타내는 그래프이다.
도 3은 본 발명의 조성물의 히알루로산 합성효소(HAS3) 발현 효과를 나타내는 그래프이다.
도 4는 본 발명의 조성물이 갖는 콜라겐 생성 효과를 나타내는 그래프이다.1 is a graph showing the melanin production inhibitory effect of the composition of the present invention.
2 is a graph showing the NO production inhibitory effect of the composition of the present invention.
3 is a graph showing the hyaluronic acid synthase (HAS3) expression effect of the composition of the present invention.
4 is a graph showing the collagen production effect of the composition of the present invention.
이하, 본 발명을 하기 실시예를 통하여 보다 상세하게 설명한다. 그러나 이들 실시예는 본 발명을 예시적으로 설명하기 위한 것으로 본 발명의 범위가 이들 실시예만으로 한정되는 것은 아니다.Hereinafter, the present invention will be described in more detail through the following examples. However, these examples are for illustrative purposes only, and the scope of the present invention is not limited to these examples only.
실시예 1: 본 발명 조성물 제조Example 1: Preparation of the composition of the present invention
1-1: 상백피 추출물 등 제조1-1: Manufacture of epiphyllum extract, etc.
아래의 과정을 통해 상백피 추출물을 제조하였으며, 마키베리 추출물 또한 동일한 과정을 수행하여 제조하였다. 상백피를 세척하고 분말화한 뒤 20배 부피의 30% 에탄올 용매에서 1시간 30분 환류 냉각 열수 추출한 후, 추출된 원액을 여과하고 감압농축하였다. 농축액은 동결건조하여 건조된 파우더로 만들어 사용하였다. 또한, 글루타치온은 시중에서 구득하여 사용하였다.An epiphyllum extract was prepared through the following process, and a macchiberry extract was also prepared by performing the same process. After washing and powdering the epidermis, it was extracted with hot water under reflux for 1 hour and 30 minutes in a 20-fold volume of 30% ethanol solvent, then the extracted stock solution was filtered and concentrated under reduced pressure. The concentrate was freeze-dried and used to make a dried powder. In addition, glutathione was used commercially obtained.
1-2: 상백피 추출물 등을 포함하는 조성물 제조1-2: Preparation of a composition comprising an extract and the like
실시예 1-2에서 준비한 글루타치온, 마키베리 추출물 및 상백피 추출물을 각각 1:1:3(제조예1), 1:1:1(제조예2), 1:3:1(제조예3) 등 다양한 비율로 혼합하여 조성물을 제조하였다.Glutathione, maquiberry extract, and sagebrush extract prepared in Example 1-2 were respectively 1:1:3 (Preparation Example 1), 1:1:1 (Preparation Example 2), 1:3:1 (Preparation Example 3), etc. The composition was prepared by mixing in various ratios.
실험예 1: 피부 미백 효과 확인Experimental Example 1: Confirmation of skin whitening effect
상기 실시예 1에서 제조된 조성물의 미백 효과를 확인하기 위해, 멜라노사이트(melanocyte)내에 존재하는 멜라닌 색소의 양이 감소하는 정도를 측정하여 평가하였다. 구체적으로, 상기 조성물을 50 μg/mL농도로 B16 멜라노사이트에 처리하고 72시간 배양한 후, 최종 생성된 멜라닌을 양을 측정하여 미백 효능을 평가하였다. 멜라닌 함량은 DMSO 대조군 기준 %로 나타내었다. 양성 대조군은 Arbutin 50 μg/mL 을 사용하였다. In order to confirm the whitening effect of the composition prepared in Example 1, the degree of decrease in the amount of melanin pigment present in melanocytes was measured and evaluated. Specifically, the composition was treated with B16 melanocytes at a concentration of 50 μg/mL and cultured for 72 hours, and the amount of finally produced melanin was measured to evaluate the whitening efficacy. Melanin content was expressed as % based on DMSO control. As a positive control, Arbutin 50 μg/mL was used.
도 1을 참조하면, 멜라닌 생성 억제 실험결과, 실시예 1의 글루타치온, 마키베리, 상백피 혼합물은 대조군 대비 멜라닌 합성을 저해하여 우수한 미백 효과를 나타냄을 알 수 있다. 특히, 글루타치온, 마키베리, 상백피 1:1:3 혼합물(제조예 1)은 다른 비율의 혼합물과 대조군의 미백 효과보다 더욱 뛰어난 시너지 효과를 나타냈다. Referring to FIG. 1 , as a result of the melanin production inhibition experiment, it can be seen that the glutathione, maquiberry, and epiphyllum mixture of Example 1 inhibits melanin synthesis compared to the control, thereby exhibiting an excellent whitening effect. In particular, a 1:1:3 mixture of glutathione, maquiberry, and sangbaekpi (Preparation Example 1) showed a more excellent synergistic effect than the whitening effect of a mixture of other ratios and the control group.
실험예 2: 피부 트러블 개선 효과 확인 Experimental Example 2: Confirmation of skin trouble improvement effect
상기 실시예 1에서 제조된 조성물의 피부 트러블 개선 효과, 항염 효과를 확인하기 위해, Raw 264.7 cell을 이용하여 NO 생성 억제 효과를 측정하였다. 양성 대조군으로는 20 mg/mL L-NMMA1(NOS 억제제)를 사용하였으며, 상기 조성물을 50 μg/mL 농도로 제조하여 세포에 처리하고 30분 후 1 μg/mL LPS를 처리하여 24시간 배양한 후 NO 정량 Kit를 이용하여 NO 생성 억제능을 평가하였다.In order to confirm the skin trouble improvement effect and anti-inflammatory effect of the composition prepared in Example 1, the NO production inhibitory effect was measured using Raw 264.7 cell. As a positive control, 20 mg/mL L-NMMA1 (NOS inhibitor) was used, and the composition was prepared at a concentration of 50 μg/mL, treated with cells, and 30 minutes later treated with 1 μg/mL LPS and cultured for 24 hours. The NO production inhibitory ability was evaluated using the NO quantification kit.
도 2를 참조하면, NO 생성 억제 실험결과, 실시예 1의 글루타치온, 마키베리, 상백피 혼합물은 대조군 대비 NO 생성을 억제하여 피부 트러블 개선에 효과가 있음을 알 수 있다. 특히, 글루타치온, 마키베리, 상백피 1:1:3 혼합물(제조예 1)은 1:1:1 혼합물(제조예 2), 1:3:1 혼합물(제조예 3)과 비교하였을 때 각각 74.88%, 81.04%, 87.06%로 유의적으로 NO 생성 억제 효과를 나타냈다. Referring to FIG. 2 , as a result of the NO production suppression experiment, it can be seen that the glutathione, macchiberry, and sangbaekpi mixture of Example 1 suppressed NO production compared to the control group, thereby improving skin troubles. In particular, glutathione, maquiberry, and sangbaekpi 1:1:3 mixture (Preparation Example 1) was 74.88%, respectively, compared to 1:1:1 mixture (Preparation Example 2) and 1:3:1 mixture (Preparation Example 3) , 81.04%, 87.06% showed a significant NO production inhibitory effect.
실험예 3: 피부 보습 효과 확인 Experimental Example 3: Confirmation of skin moisturizing effect
상기 실시예 1에서 제조된 조성물의 보습 효과를 확인하기 위해, 히알루로산 합성효소(Hyaluronan Synthases 3, HAS3)의 활성 증진 효과를 평가하였다. 구체적으로, 각질형성세포(HaCaT, Human keratinocyte)를 6 welll plate 에 5 X 105cell/well의 밀도로 3 mL의 배양액과 함께 분주한 뒤, 37℃, 5% CO2 배양기에서 24시간 배양하였다. 배양액을 제거하고, PBS로 1회 세척하였다. serum free 배양액에 실시예 1의 조성물을 50 μg/mL로 제조하여 각각 3 mL씩 처리한 후 24시간 배양하였고 RT-PCR을 수행하여 HAS3 mRNA양을 비교하였다.In order to confirm the moisturizing effect of the composition prepared in Example 1, the activity enhancing effect of hyaluronan synthase (Hyaluronan Synthases 3, HAS3) was evaluated. Specifically, keratinocytes (HaCaT, human keratinocyte) were aliquoted with 3 mL of a culture solution at a density of 5 X 10 5 cells/well in a 6 well plate, and cultured at 37° C., 5% CO 2 in an incubator for 24 hours. . The culture medium was removed and washed once with PBS. The composition of Example 1 was prepared at 50 μg/mL in a serum-free culture medium, treated with 3 mL each, and cultured for 24 hours, and RT-PCR was performed to compare HAS3 mRNA levels.
도 3을 참조하면, 글루타치온, 마키베리, 상백피 1:1:3 혼합물(제조예 1)의 경우 대조군과 비교하였을 때 Hyaluronic acid synthases 합성이 통계적으로 유의적인 차이를 나타냈다. 결과적으로 실시예 1의 글루타치온, 마키베리, 상백피 혼합물은 피부 수분손실을 억제시킴으로써, 피부 보습력에 우수한 효과를 발휘하고 있음을 알 수 있다. Referring to FIG. 3 , in the case of a 1:1:3 mixture of glutathione, maquiberry, and sangbaekpi (Preparation Example 1), the synthesis of hyaluronic acid synthases showed a statistically significant difference compared to the control group. As a result, it can be seen that the mixture of glutathione, maquiberry, and epidermis of Example 1 exerts an excellent effect on skin moisture by suppressing skin moisture loss.
실험예 4: 피부 주름 개선 효과 확인 Experimental Example 4: Confirmation of skin wrinkle improvement effect
상기 실시예 1에서 제조된 조성물의 피부 주름 개선 효과를 확인하기 위해, 키트(procollagen type-1 C-peptide EIA kit, Takara, Japan)를 사용하여 프로 콜라겐의 합성을 측정하였다. In order to confirm the skin wrinkle improvement effect of the composition prepared in Example 1, procollagen synthesis was measured using a kit (procollagen type-1 C-peptide EIA kit, Takara, Japan).
구체적으로, HDF(Human Dermal Fibroblast) 세포를 5 × 104 cell/㎖의 밀도로 24 well plate에 1 mL분주하고, 실시예 1의 조성물 50 μg/mL 농도로 처리하여 37℃, 5% CO2 배양기에서 48시간 동안 배양하였다. anti-PIP antibody 코팅된 96 well plate에 항체-POD가 결합된 용액 (antibody-POD conjugate sol'n) 100 μL를 넣고 대조군 및 상기 조성물에 표준액 20 μL를 첨가하고 알루미늄 호일로 차광시킨 후 3 시간 동안 37°C에서 배양하였다. 이후 배양액을 제거하고 PBS로 4 회 세척 후, 기질용액 100 μL를 첨가한 후 실온에서 15 분간 방치한 후, H2SO4 100 μL를 첨가하여 가볍게 흔든 후, 450 nm에서 흡광도를 측정하였다.Specifically, 1 mL of HDF (Human Dermal Fibroblast) cells were aliquoted in a 24 well plate at a density of 5 × 10 4 cell/ml, and treated with the composition of Example 1 at a concentration of 50 μg/mL at 37°C, 5% CO 2 Incubated for 48 hours in an incubator. Add 100 μL of antibody-POD conjugate sol'n to an anti-PIP antibody-coated 96 well plate, add 20 μL of standard solution to the control and the composition, and block the light with aluminum foil for 3 hours Incubated at 37 °C. After removing the culture solution and washing 4 times with PBS, after adding 100 μL of the substrate solution and leaving it at room temperature for 15 minutes, H 2 SO 4 100 μL was added and shaken lightly, and the absorbance was measured at 450 nm.
도 4를 참조하면, 글루타치온, 마키베리, 상백피 1:1:3 혼합물(제조예 1)은 대조군과 비교하였을 때 Procollagen 합성에 유의적인 상승효과를 보이고 있다. 결과적으로 실시예 1의 글루타치온, 마키베리, 상백피 혼합물은 Procollagen 합성을 증가시켜 피부 주름개선 효과를 기대할 수 있다. Referring to FIG. 4 , a 1:1:3 mixture of glutathione, maquiberry, and sangbaekpi (Preparation Example 1) showed a significant synergistic effect on procollagen synthesis compared to the control group. As a result, the mixture of glutathione, maquiberry, and epidermis of Example 1 can increase the synthesis of procollagen, so that the skin wrinkle improvement effect can be expected.
이상의 설명으로부터, 본 발명이 속하는 기술분야의 당업자는 본 발명이 그 기술적 사상이나 필수적 특징을 변경하지 않고서 다른 구체적인 형태로 실시될 수 있다는 것을 이해할 수 있을 것이다. 이와 관련하여, 이상에서 기술한 실시예들은 모든 면에서 예시적인 것이며 한정적인 것이 아닌 것으로 이해해야만 한다. 본 발명의 범위는 상기 상세한 설명보다는 후술하는 특허 청구범위의 의미 및 범위 그리고 그 등가 개념으로부터 도출되는 모든 변경 또는 변형된 형태가 본 발명의 범위에 포함되는 것으로 해석되어야 한다. From the above description, those skilled in the art to which the present invention pertains will understand that the present invention may be embodied in other specific forms without changing the technical spirit or essential characteristics thereof. In this regard, it should be understood that the embodiments described above are illustrative in all respects and not restrictive. The scope of the present invention should be construed as being included in the scope of the present invention, rather than the above detailed description, all changes or modifications derived from the meaning and scope of the following claims and their equivalents.
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| JP2006347975A (en) * | 2005-06-17 | 2006-12-28 | Bio Solutions:Kk | Oral composition for cardiovascular disease prophylaxis and amelioration |
| KR20190136512A (en) * | 2018-05-31 | 2019-12-10 | 숙명여자대학교산학협력단 | Composition for preventing or treating menopausal syndrome of women comprising Aristotelia chilensis extract, Angelica sinensis extract and Passiflora incarnata extract as an active ingredient |
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| JP2004238386A (en) * | 2002-12-11 | 2004-08-26 | Mikimoto Pharmaceut Co Ltd | Medicament, quasi-drug and cosmetic |
| JP2006347975A (en) * | 2005-06-17 | 2006-12-28 | Bio Solutions:Kk | Oral composition for cardiovascular disease prophylaxis and amelioration |
| KR20190136512A (en) * | 2018-05-31 | 2019-12-10 | 숙명여자대학교산학협력단 | Composition for preventing or treating menopausal syndrome of women comprising Aristotelia chilensis extract, Angelica sinensis extract and Passiflora incarnata extract as an active ingredient |
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