KR20200124020A - Composition for skin whitening comprising Tradescantia pallida extract - Google Patents
Composition for skin whitening comprising Tradescantia pallida extract Download PDFInfo
- Publication number
- KR20200124020A KR20200124020A KR1020190047350A KR20190047350A KR20200124020A KR 20200124020 A KR20200124020 A KR 20200124020A KR 1020190047350 A KR1020190047350 A KR 1020190047350A KR 20190047350 A KR20190047350 A KR 20190047350A KR 20200124020 A KR20200124020 A KR 20200124020A
- Authority
- KR
- South Korea
- Prior art keywords
- extract
- skin whitening
- composition
- tradescantia
- chicken
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 46
- 239000000284 extract Substances 0.000 title claims abstract description 41
- 230000002087 whitening effect Effects 0.000 title claims abstract description 30
- 241000605550 Tradescantia pallida Species 0.000 title claims abstract description 16
- 102000003425 Tyrosinase Human genes 0.000 claims abstract description 17
- 108060008724 Tyrosinase Proteins 0.000 claims abstract description 17
- 239000004480 active ingredient Substances 0.000 claims abstract description 17
- 239000002537 cosmetic Substances 0.000 claims abstract description 14
- 230000002401 inhibitory effect Effects 0.000 claims abstract description 11
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 9
- 241000287828 Gallus gallus Species 0.000 claims description 28
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 22
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims description 18
- 230000000694 effects Effects 0.000 claims description 17
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 12
- 235000013402 health food Nutrition 0.000 claims description 9
- 239000003153 chemical reaction reagent Substances 0.000 claims description 8
- 239000002904 solvent Substances 0.000 claims description 5
- 230000003078 antioxidant effect Effects 0.000 abstract description 5
- 210000003491 skin Anatomy 0.000 description 29
- -1 foundation Substances 0.000 description 11
- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 description 10
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 9
- 238000002360 preparation method Methods 0.000 description 9
- 238000009472 formulation Methods 0.000 description 8
- BJRNKVDFDLYUGJ-RMPHRYRLSA-N hydroquinone O-beta-D-glucopyranoside Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC=C(O)C=C1 BJRNKVDFDLYUGJ-RMPHRYRLSA-N 0.000 description 8
- 239000000049 pigment Substances 0.000 description 8
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 6
- MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 description 6
- 238000000034 method Methods 0.000 description 6
- 239000000546 pharmaceutical excipient Substances 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- 239000000843 powder Substances 0.000 description 5
- 235000001674 Agaricus brunnescens Nutrition 0.000 description 4
- 102000008186 Collagen Human genes 0.000 description 4
- 108010035532 Collagen Proteins 0.000 description 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerol Natural products OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 4
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 4
- 244000236151 Tabebuia pallida Species 0.000 description 4
- 238000002835 absorbance Methods 0.000 description 4
- 229960000271 arbutin Drugs 0.000 description 4
- 229920001436 collagen Polymers 0.000 description 4
- 239000003085 diluting agent Substances 0.000 description 4
- 239000000839 emulsion Substances 0.000 description 4
- 229930003935 flavonoid Natural products 0.000 description 4
- 150000002215 flavonoids Chemical class 0.000 description 4
- 235000017173 flavonoids Nutrition 0.000 description 4
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 4
- BJRNKVDFDLYUGJ-UHFFFAOYSA-N p-hydroxyphenyl beta-D-alloside Natural products OC1C(O)C(O)C(CO)OC1OC1=CC=C(O)C=C1 BJRNKVDFDLYUGJ-UHFFFAOYSA-N 0.000 description 4
- 150000008442 polyphenolic compounds Chemical class 0.000 description 4
- 235000013824 polyphenols Nutrition 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- 239000000454 talc Substances 0.000 description 4
- 229910052623 talc Inorganic materials 0.000 description 4
- 235000012222 talc Nutrition 0.000 description 4
- TUSDEZXZIZRFGC-UHFFFAOYSA-N 1-O-galloyl-3,6-(R)-HHDP-beta-D-glucose Natural products OC1C(O2)COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC1C(O)C2OC(=O)C1=CC(O)=C(O)C(O)=C1 TUSDEZXZIZRFGC-UHFFFAOYSA-N 0.000 description 3
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 description 3
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 description 3
- 239000001263 FEMA 3042 Substances 0.000 description 3
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 3
- LRBQNJMCXXYXIU-PPKXGCFTSA-N Penta-digallate-beta-D-glucose Natural products OC1=C(O)C(O)=CC(C(=O)OC=2C(=C(O)C=C(C=2)C(=O)OC[C@@H]2[C@H]([C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)O2)OC(=O)C=2C=C(OC(=O)C=3C=C(O)C(O)=C(O)C=3)C(O)=C(O)C=2)O)=C1 LRBQNJMCXXYXIU-PPKXGCFTSA-N 0.000 description 3
- 239000002202 Polyethylene glycol Substances 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 229920002472 Starch Polymers 0.000 description 3
- 244000299461 Theobroma cacao Species 0.000 description 3
- 239000001913 cellulose Substances 0.000 description 3
- 235000010980 cellulose Nutrition 0.000 description 3
- 229920002678 cellulose Polymers 0.000 description 3
- 210000004207 dermis Anatomy 0.000 description 3
- 210000002744 extracellular matrix Anatomy 0.000 description 3
- 239000000796 flavoring agent Substances 0.000 description 3
- 235000013373 food additive Nutrition 0.000 description 3
- 239000002778 food additive Substances 0.000 description 3
- 235000013355 food flavoring agent Nutrition 0.000 description 3
- 239000008101 lactose Substances 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 229920001223 polyethylene glycol Polymers 0.000 description 3
- 239000013641 positive control Substances 0.000 description 3
- 239000003755 preservative agent Substances 0.000 description 3
- 239000007921 spray Substances 0.000 description 3
- 239000008107 starch Substances 0.000 description 3
- 235000019698 starch Nutrition 0.000 description 3
- 239000000725 suspension Substances 0.000 description 3
- LRBQNJMCXXYXIU-NRMVVENXSA-N tannic acid Chemical compound OC1=C(O)C(O)=CC(C(=O)OC=2C(=C(O)C=C(C=2)C(=O)OC[C@@H]2[C@H]([C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)O2)OC(=O)C=2C=C(OC(=O)C=3C=C(O)C(O)=C(O)C=3)C(O)=C(O)C=2)O)=C1 LRBQNJMCXXYXIU-NRMVVENXSA-N 0.000 description 3
- 235000015523 tannic acid Nutrition 0.000 description 3
- 229920002258 tannic acid Polymers 0.000 description 3
- 229940033123 tannic acid Drugs 0.000 description 3
- 210000001519 tissue Anatomy 0.000 description 3
- 239000011782 vitamin Substances 0.000 description 3
- 235000013343 vitamin Nutrition 0.000 description 3
- 229940088594 vitamin Drugs 0.000 description 3
- 229930003231 vitamin Natural products 0.000 description 3
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 2
- JMGZEFIQIZZSBH-UHFFFAOYSA-N Bioquercetin Natural products CC1OC(OCC(O)C2OC(OC3=C(Oc4cc(O)cc(O)c4C3=O)c5ccc(O)c(O)c5)C(O)C2O)C(O)C(O)C1O JMGZEFIQIZZSBH-UHFFFAOYSA-N 0.000 description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 2
- LCGLNKUTAGEVQW-UHFFFAOYSA-N Dimethyl ether Chemical compound COC LCGLNKUTAGEVQW-UHFFFAOYSA-N 0.000 description 2
- 102000016942 Elastin Human genes 0.000 description 2
- 108010014258 Elastin Proteins 0.000 description 2
- 108010010803 Gelatin Proteins 0.000 description 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 2
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 2
- 229920000168 Microcrystalline cellulose Polymers 0.000 description 2
- 102000013760 Microphthalmia-Associated Transcription Factor Human genes 0.000 description 2
- 108010050345 Microphthalmia-Associated Transcription Factor Proteins 0.000 description 2
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 description 2
- 208000012641 Pigmentation disease Diseases 0.000 description 2
- ATUOYWHBWRKTHZ-UHFFFAOYSA-N Propane Chemical compound CCC ATUOYWHBWRKTHZ-UHFFFAOYSA-N 0.000 description 2
- 208000000453 Skin Neoplasms Diseases 0.000 description 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 2
- 229930006000 Sucrose Natural products 0.000 description 2
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 description 2
- 235000010443 alginic acid Nutrition 0.000 description 2
- 229920000615 alginic acid Polymers 0.000 description 2
- 239000003125 aqueous solvent Substances 0.000 description 2
- 239000002585 base Substances 0.000 description 2
- 239000000440 bentonite Substances 0.000 description 2
- 229910000278 bentonite Inorganic materials 0.000 description 2
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 2
- SESFRYSPDFLNCH-UHFFFAOYSA-N benzyl benzoate Chemical compound C=1C=CC=CC=1C(=O)OCC1=CC=CC=C1 SESFRYSPDFLNCH-UHFFFAOYSA-N 0.000 description 2
- 235000013361 beverage Nutrition 0.000 description 2
- 239000000378 calcium silicate Substances 0.000 description 2
- 229910052918 calcium silicate Inorganic materials 0.000 description 2
- 235000012241 calcium silicate Nutrition 0.000 description 2
- OYACROKNLOSFPA-UHFFFAOYSA-N calcium;dioxido(oxo)silane Chemical compound [Ca+2].[O-][Si]([O-])=O OYACROKNLOSFPA-UHFFFAOYSA-N 0.000 description 2
- 238000011088 calibration curve Methods 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 235000019219 chocolate Nutrition 0.000 description 2
- 235000009508 confectionery Nutrition 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 239000006071 cream Substances 0.000 description 2
- 230000001419 dependent effect Effects 0.000 description 2
- 231100000673 dose–response relationship Toxicity 0.000 description 2
- HHEAADYXPMHMCT-UHFFFAOYSA-N dpph Chemical compound [O-][N+](=O)C1=CC([N+](=O)[O-])=CC([N+]([O-])=O)=C1[N]N(C=1C=CC=CC=1)C1=CC=CC=C1 HHEAADYXPMHMCT-UHFFFAOYSA-N 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 229920002549 elastin Polymers 0.000 description 2
- IVTMALDHFAHOGL-UHFFFAOYSA-N eriodictyol 7-O-rutinoside Natural products OC1C(O)C(O)C(C)OC1OCC1C(O)C(O)C(O)C(OC=2C=C3C(C(C(O)=C(O3)C=3C=C(O)C(O)=CC=3)=O)=C(O)C=2)O1 IVTMALDHFAHOGL-UHFFFAOYSA-N 0.000 description 2
- 239000010200 folin Substances 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 239000003205 fragrance Substances 0.000 description 2
- 235000015203 fruit juice Nutrition 0.000 description 2
- 239000000499 gel Substances 0.000 description 2
- 239000008273 gelatin Substances 0.000 description 2
- 229920000159 gelatin Polymers 0.000 description 2
- 235000019322 gelatine Nutrition 0.000 description 2
- 235000011852 gelatine desserts Nutrition 0.000 description 2
- 235000011187 glycerol Nutrition 0.000 description 2
- 239000008187 granular material Substances 0.000 description 2
- 230000005764 inhibitory process Effects 0.000 description 2
- 210000002510 keratinocyte Anatomy 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000006210 lotion Substances 0.000 description 2
- 235000019359 magnesium stearate Nutrition 0.000 description 2
- 210000002752 melanocyte Anatomy 0.000 description 2
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 2
- 239000008108 microcrystalline cellulose Substances 0.000 description 2
- 229940016286 microcrystalline cellulose Drugs 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 229920000136 polysorbate Polymers 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- FDRQPMVGJOQVTL-UHFFFAOYSA-N quercetin rutinoside Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 FDRQPMVGJOQVTL-UHFFFAOYSA-N 0.000 description 2
- 235000005493 rutin Nutrition 0.000 description 2
- IKGXIBQEEMLURG-BKUODXTLSA-N rutin Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@@H]1OC[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 IKGXIBQEEMLURG-BKUODXTLSA-N 0.000 description 2
- ALABRVAAKCSLSC-UHFFFAOYSA-N rutin Natural products CC1OC(OCC2OC(O)C(O)C(O)C2O)C(O)C(O)C1OC3=C(Oc4cc(O)cc(O)c4C3=O)c5ccc(O)c(O)c5 ALABRVAAKCSLSC-UHFFFAOYSA-N 0.000 description 2
- 229960004555 rutoside Drugs 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 239000000377 silicon dioxide Substances 0.000 description 2
- 201000000849 skin cancer Diseases 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 239000000600 sorbitol Substances 0.000 description 2
- 235000010356 sorbitol Nutrition 0.000 description 2
- 239000003381 stabilizer Substances 0.000 description 2
- 239000005720 sucrose Substances 0.000 description 2
- 239000000829 suppository Substances 0.000 description 2
- 239000000375 suspending agent Substances 0.000 description 2
- 239000003826 tablet Substances 0.000 description 2
- 239000002562 thickening agent Substances 0.000 description 2
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 2
- 235000015112 vegetable and seed oil Nutrition 0.000 description 2
- 239000008158 vegetable oil Substances 0.000 description 2
- 239000000080 wetting agent Substances 0.000 description 2
- JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical compound OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 description 1
- WBYWAXJHAXSJNI-VOTSOKGWSA-M .beta-Phenylacrylic acid Natural products [O-]C(=O)\C=C\C1=CC=CC=C1 WBYWAXJHAXSJNI-VOTSOKGWSA-M 0.000 description 1
- WNWHHMBRJJOGFJ-UHFFFAOYSA-N 16-methylheptadecan-1-ol Chemical class CC(C)CCCCCCCCCCCCCCCO WNWHHMBRJJOGFJ-UHFFFAOYSA-N 0.000 description 1
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 description 1
- 244000215068 Acacia senegal Species 0.000 description 1
- 235000006491 Acacia senegal Nutrition 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- PTHCMJGKKRQCBF-UHFFFAOYSA-N Cellulose, microcrystalline Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC)C(CO)O1 PTHCMJGKKRQCBF-UHFFFAOYSA-N 0.000 description 1
- WBYWAXJHAXSJNI-SREVYHEPSA-N Cinnamic acid Chemical compound OC(=O)\C=C/C1=CC=CC=C1 WBYWAXJHAXSJNI-SREVYHEPSA-N 0.000 description 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- LVGKNOAMLMIIKO-UHFFFAOYSA-N Elaidinsaeure-aethylester Natural products CCCCCCCCC=CCCCCCCCC(=O)OCC LVGKNOAMLMIIKO-UHFFFAOYSA-N 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 206010014970 Ephelides Diseases 0.000 description 1
- 206010015150 Erythema Diseases 0.000 description 1
- 239000004386 Erythritol Substances 0.000 description 1
- UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 239000004471 Glycine Substances 0.000 description 1
- 229920002907 Guar gum Polymers 0.000 description 1
- 229920000084 Gum arabic Polymers 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- 208000003351 Melanosis Diseases 0.000 description 1
- CBENFWSGALASAD-UHFFFAOYSA-N Ozone Chemical compound [O-][O+]=O CBENFWSGALASAD-UHFFFAOYSA-N 0.000 description 1
- 229920002230 Pectic acid Polymers 0.000 description 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
- 239000004952 Polyamide Substances 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- 230000002292 Radical scavenging effect Effects 0.000 description 1
- 244000269722 Thea sinensis Species 0.000 description 1
- 235000005764 Theobroma cacao ssp. cacao Nutrition 0.000 description 1
- 235000005767 Theobroma cacao ssp. sphaerocarpum Nutrition 0.000 description 1
- 102000040945 Transcription factor Human genes 0.000 description 1
- 108091023040 Transcription factor Proteins 0.000 description 1
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 1
- 230000005856 abnormality Effects 0.000 description 1
- 239000003655 absorption accelerator Substances 0.000 description 1
- 235000010489 acacia gum Nutrition 0.000 description 1
- 239000000443 aerosol Substances 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 229940072056 alginate Drugs 0.000 description 1
- 239000000783 alginic acid Substances 0.000 description 1
- 229960001126 alginic acid Drugs 0.000 description 1
- 150000004781 alginic acids Chemical class 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 description 1
- 239000010775 animal oil Substances 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 239000012752 auxiliary agent Substances 0.000 description 1
- 229960002903 benzyl benzoate Drugs 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 235000008429 bread Nutrition 0.000 description 1
- 239000001273 butane Substances 0.000 description 1
- 235000014121 butter Nutrition 0.000 description 1
- 235000001046 cacaotero Nutrition 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- 239000001506 calcium phosphate Substances 0.000 description 1
- 229910000389 calcium phosphate Inorganic materials 0.000 description 1
- 235000011010 calcium phosphates Nutrition 0.000 description 1
- 235000014171 carbonated beverage Nutrition 0.000 description 1
- 150000004649 carbonic acid derivatives Chemical class 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 230000021164 cell adhesion Effects 0.000 description 1
- 230000024245 cell differentiation Effects 0.000 description 1
- 230000032823 cell division Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 235000013351 cheese Nutrition 0.000 description 1
- 150000005827 chlorofluoro hydrocarbons Chemical class 0.000 description 1
- 229930016911 cinnamic acid Natural products 0.000 description 1
- 235000013985 cinnamic acid Nutrition 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 210000002808 connective tissue Anatomy 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000007123 defense Effects 0.000 description 1
- 210000001787 dendrite Anatomy 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 239000008121 dextrose Substances 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- MGJZITXUQXWAKY-UHFFFAOYSA-N diphenyl-(2,4,6-trinitrophenyl)iminoazanium Chemical compound [O-][N+](=O)C1=CC([N+](=O)[O-])=CC([N+]([O-])=O)=C1N=[N+](C=1C=CC=CC=1)C1=CC=CC=C1 MGJZITXUQXWAKY-UHFFFAOYSA-N 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000007884 disintegrant Substances 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 239000003792 electrolyte Substances 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 238000003912 environmental pollution Methods 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 231100000321 erythema Toxicity 0.000 description 1
- 235000019414 erythritol Nutrition 0.000 description 1
- UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 description 1
- 229940009714 erythritol Drugs 0.000 description 1
- 239000000686 essence Substances 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 239000000469 ethanolic extract Substances 0.000 description 1
- 239000002024 ethyl acetate extract Substances 0.000 description 1
- LVGKNOAMLMIIKO-QXMHVHEDSA-N ethyl oleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC LVGKNOAMLMIIKO-QXMHVHEDSA-N 0.000 description 1
- 229940093471 ethyl oleate Drugs 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 210000002950 fibroblast Anatomy 0.000 description 1
- 102000034240 fibrous proteins Human genes 0.000 description 1
- 108091005899 fibrous proteins Proteins 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- 230000007760 free radical scavenging Effects 0.000 description 1
- 238000012812 general test Methods 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 229960002989 glutamic acid Drugs 0.000 description 1
- 229960002449 glycine Drugs 0.000 description 1
- 239000000665 guar gum Substances 0.000 description 1
- 235000010417 guar gum Nutrition 0.000 description 1
- 229960002154 guar gum Drugs 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 235000015243 ice cream Nutrition 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- VMPHSYLJUKZBJJ-UHFFFAOYSA-N lauric acid triglyceride Natural products CCCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCC)COC(=O)CCCCCCCCCCC VMPHSYLJUKZBJJ-UHFFFAOYSA-N 0.000 description 1
- 229940069445 licorice extract Drugs 0.000 description 1
- 229940057995 liquid paraffin Drugs 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 239000000845 maltitol Substances 0.000 description 1
- 235000010449 maltitol Nutrition 0.000 description 1
- VQHSOMBJVWLPSR-WUJBLJFYSA-N maltitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-WUJBLJFYSA-N 0.000 description 1
- 229940035436 maltitol Drugs 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 230000008099 melanin synthesis Effects 0.000 description 1
- 230000003061 melanogenesis Effects 0.000 description 1
- 210000002780 melanosome Anatomy 0.000 description 1
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 1
- 239000000401 methanolic extract Substances 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- WBYWAXJHAXSJNI-UHFFFAOYSA-N methyl p-hydroxycinnamate Natural products OC(=O)C=CC1=CC=CC=C1 WBYWAXJHAXSJNI-UHFFFAOYSA-N 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 235000010981 methylcellulose Nutrition 0.000 description 1
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
- 239000002480 mineral oil Substances 0.000 description 1
- CQDGTJPVBWZJAZ-UHFFFAOYSA-N monoethyl carbonate Chemical compound CCOC(O)=O CQDGTJPVBWZJAZ-UHFFFAOYSA-N 0.000 description 1
- IJDNQMDRQITEOD-UHFFFAOYSA-N n-butane Chemical compound CCCC IJDNQMDRQITEOD-UHFFFAOYSA-N 0.000 description 1
- OFBQJSOFQDEBGM-UHFFFAOYSA-N n-pentane Natural products CCCCC OFBQJSOFQDEBGM-UHFFFAOYSA-N 0.000 description 1
- 235000019462 natural additive Nutrition 0.000 description 1
- 239000011664 nicotinic acid Substances 0.000 description 1
- 229960003512 nicotinic acid Drugs 0.000 description 1
- 235000001968 nicotinic acid Nutrition 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 235000019198 oils Nutrition 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 235000008390 olive oil Nutrition 0.000 description 1
- 239000004006 olive oil Substances 0.000 description 1
- 239000006186 oral dosage form Substances 0.000 description 1
- 210000003463 organelle Anatomy 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 239000006072 paste Substances 0.000 description 1
- LCLHHZYHLXDRQG-ZNKJPWOQSA-N pectic acid Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)O[C@H](C(O)=O)[C@@H]1OC1[C@H](O)[C@@H](O)[C@@H](OC2[C@@H]([C@@H](O)[C@@H](O)[C@H](O2)C(O)=O)O)[C@@H](C(O)=O)O1 LCLHHZYHLXDRQG-ZNKJPWOQSA-N 0.000 description 1
- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
- 230000019612 pigmentation Effects 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 235000013550 pizza Nutrition 0.000 description 1
- 229920002647 polyamide Polymers 0.000 description 1
- 239000010318 polygalacturonic acid Substances 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229960003975 potassium Drugs 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000001508 potassium citrate Substances 0.000 description 1
- 229960002635 potassium citrate Drugs 0.000 description 1
- QEEAPRPFLLJWCF-UHFFFAOYSA-K potassium citrate (anhydrous) Chemical compound [K+].[K+].[K+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O QEEAPRPFLLJWCF-UHFFFAOYSA-K 0.000 description 1
- 235000011082 potassium citrates Nutrition 0.000 description 1
- USHAGKDGDHPEEY-UHFFFAOYSA-L potassium persulfate Chemical compound [K+].[K+].[O-]S(=O)(=O)OOS([O-])(=O)=O USHAGKDGDHPEEY-UHFFFAOYSA-L 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 230000000644 propagated effect Effects 0.000 description 1
- 239000001294 propane Substances 0.000 description 1
- 239000003380 propellant Substances 0.000 description 1
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 1
- 229960003415 propylparaben Drugs 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 235000013580 sausages Nutrition 0.000 description 1
- 230000002000 scavenging effect Effects 0.000 description 1
- 239000002453 shampoo Substances 0.000 description 1
- 230000037384 skin absorption Effects 0.000 description 1
- 231100000274 skin absorption Toxicity 0.000 description 1
- 230000009759 skin aging Effects 0.000 description 1
- 210000004927 skin cell Anatomy 0.000 description 1
- 235000011888 snacks Nutrition 0.000 description 1
- 239000012064 sodium phosphate buffer Substances 0.000 description 1
- 235000014347 soups Nutrition 0.000 description 1
- 210000000434 stratum corneum Anatomy 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000000475 sunscreen effect Effects 0.000 description 1
- 239000000516 sunscreening agent Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 235000013616 tea Nutrition 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 229960004441 tyrosine Drugs 0.000 description 1
- 235000002374 tyrosine Nutrition 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
- 230000037373 wrinkle formation Effects 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
- 239000011787 zinc oxide Substances 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2200/00—Function of food ingredients
- A23V2200/30—Foods, ingredients or supplements having a functional effect on health
- A23V2200/318—Foods, ingredients or supplements having a functional effect on health having an effect on skin health and hair or coat
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Botany (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Mycology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Dermatology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biotechnology (AREA)
- Epidemiology (AREA)
- Medical Informatics (AREA)
- Polymers & Plastics (AREA)
- Alternative & Traditional Medicine (AREA)
- Food Science & Technology (AREA)
- Birds (AREA)
- Nutrition Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Cosmetics (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
Description
본 발명은 팔리다자주닭개비 추출물을 유효성분으로 포함하는 피부 미백용 조성물에 관한 것이다.The present invention relates to a composition for skin whitening comprising an extract of Palidajaju chicken gaebi as an active ingredient.
피부는 인체의 물리적·생화학적 방어 기능을 수행하는 주요 조직 중의 하나로, 표피(epidermis), 진피(dermis) 및 피하층(hypodermis)으로 구성되어 있으며, 이중 진피에는 섬유아세포(fibroblast)로부터 생성되는 콜라겐(collagen)과 엘라스틴(elastin) 등으로 구성된 세포외기질(extracellular matrix; ECM)이 존재하여 피부의 탄력을 조절하고 주름 생성에 관여한다. 진피의 90% 이상을 차지하고 있는 콜라겐은 피부의 기계적 견고성, 결합조직의 저항력과 조직의 결합력, 세포 접착의 지탱, 세포 분할과 분화 유도 등의 기능을 수행하며, 진피층의 2-4% 정도를 차지하고 있는 엘라스틴은 불용성 섬유단백질로서 콜라겐 다발을 감싸는 기능을 수행한다.Skin is one of the major tissues that perform physical and biochemical defense functions of the human body, and is composed of epidermis, dermis, and hypodermis, and collagen produced from fibroblasts in the dermis ( There is an extracellular matrix (ECM) composed of collagen) and elastin, which regulates the elasticity of the skin and is involved in wrinkle formation. Collagen, which occupies more than 90% of the dermis, performs functions such as mechanical firmness of the skin, resistance of connective tissue and binding force of tissues, support of cell adhesion, induction of cell division and differentiation, and occupies about 2-4% of the dermal layer. The present elastin is an insoluble fibrous protein and performs the function of wrapping collagen bundles.
한편, 현대사회는 평균 수명의 연장, 레저 활동의 증가로 인한 UV 노출 기회 증가, 환경오염에 의한 오존층 파괴 및 이에 따른 UV의 절대량 증가 등으로 인해 홍반반응, 색소반응, 피부노화, 피부암 등의 피부 변화가 증가하고 있다. 특히 UV에 장기간 노출되면 피부 각질층이 두꺼워지고 피부의 구성요소들인 세포 외 기질들이 변성되어 피부의 탄력성이 감소하고 피부 색소에 이상현상을 일으켜 멜라닌 과다 생성 등이 초래된다. On the other hand, in modern society, skin such as erythema reactions, pigment reactions, skin aging, skin cancer, etc., due to the increase of the average life span, increased opportunities for UV exposure due to the increase in leisure activities, the destruction of the ozone layer due to environmental pollution, and the increase in the absolute amount of UV. Change is increasing. In particular, when exposed to UV for a long period of time, the stratum corneum of the skin becomes thick and the extracellular matrix, which is a component of the skin, is denatured, reducing the elasticity of the skin and causing abnormalities in the skin pigment, resulting in excessive production of melanin.
피부색의 결정요인으로 작용하는 멜라닌(melanin)은 적갈색(phomelanin) 또는 흑갈색(eumelanin)의 고분자 화합물로서 멜라닌세포(melanocyte) 내 멜라닌소체(melanosome)라는 소기관에서 합성된다. 합성된 멜라닌 색소는 멜라닌세포의 수지상돌기(dendrite)를 통하여 인접세포인 각질형성세포(keratinocyte)로 전달되며, 전달된 멜라닌 색소는 각질형성세포를 통해 피부 내 여러 부위에 분포하게 된다. 멜라닌 합성에 있어 가장 중요한 세포 내 인자는 microphthalmia-associated transcription factor(MITF)라 불리는 전사인자이며, 이 전사인자는 최종적인 멜라닌 생성과정을 촉매하는 티로시나아제(tyrosinase)의 발현을 증가시키는 역할을 담당한다. 자외선, 호르몬, 염증 등의 원인에 의해 과도하게 생성된 멜라닌은 피부에 색소를 침착시켜 기미, 주근깨를 형성하며, 피부암의 원인이 되기도 한다. 따라서 젊고 아름다운 피부를 유지하기 위해서는 피부세포 및 조직을 보호할 수 있는 항산화제 개발과 함께 새로운 미백제 개발이 필요하다.Melanin, which acts as a determinant of skin color, is a polymer compound of phomelanin or eumelanin, which is synthesized in organelles called melanosomes in melanocytes. The synthesized melanin pigment is delivered to adjacent cells, keratinocytes, through dendrites of melanocytes, and the delivered melanin pigments are distributed in various parts of the skin through the keratinocytes. The most important intracellular factor in melanin synthesis is a transcription factor called microphthalmia-associated transcription factor (MITF), which is responsible for increasing the expression of tyrosinase, which catalyzes the final melanogenesis process. do. Melanin, which is excessively produced by causes such as ultraviolet rays, hormones, and inflammation, deposits pigment on the skin to form spots and freckles, and may also cause skin cancer. Therefore, in order to maintain young and beautiful skin, it is necessary to develop a new whitening agent along with the development of antioxidants that can protect skin cells and tissues.
한편, 팔리다자주닭개비(Tradescantia pallida)는 닭의장풀과에 속하는 다육질의 상록성 숙근초로 멕시코 북동부가 원산지이다. 꽃은 3개의 분홍색 꽃잎과 노란색 수술을 가지고 있으며, 잎줄기는 보라색을 띤다. 꺾꽂이를 통해 쉽게 번식이 가능하며, 관상용으로 재배가 되고 있다. 팔리다자주닭개비의 생리활성 연구는 최근 말레이시아에서 채취한 잎에서 항산화능과 항균활성 연구가 보고되었을 뿐 국내에 도입된 이후 현재까지 관련 연구가 전무한 실정이다.Meanwhile, Tradescantia pallida is a fleshy, evergreen sukkeun herb belonging to the family Chicken Epiaceae and is native to northeastern Mexico. The flower has 3 pink petals and yellow stamens, and the leaf stem is purple. It can be easily propagated through cuttings and is cultivated for ornamental purposes. As for the physiological activity of Palidajaju chicken gaebi, studies on the antioxidant activity and antibacterial activity of leaves collected in Malaysia have recently been reported, but there have been no related studies since it was introduced in Korea.
본 발명의 목적은 피부 미백용 화장료 조성물, 피부 미백용 약학 조성물, 또는 피부 미백용 건강식품 조성물을 제공하는 데에 있다.An object of the present invention is to provide a cosmetic composition for skin whitening, a pharmaceutical composition for skin whitening, or a health food composition for skin whitening.
본 발명의 다른 목적은 티로시나아제 활성 억제용 시약 조성물을 제공하는 데에 있다.Another object of the present invention is to provide a reagent composition for inhibiting tyrosinase activity.
상기 목적을 달성하기 위하여, 본 발명은 팔리다자주닭개비(Tradescantia pallida) 추출물을 유효성분으로 포함하는 피부 미백용 화장료 조성물을 제공한다.In order to achieve the above object, the present invention provides a cosmetic composition for skin whitening comprising an extract of Palidajaju chicken ( Tradescantia pallida ) as an active ingredient.
또한, 본 발명은 팔리다자주닭개비(Tradescantia pallida) 추출물을 유효성분으로 포함하는 피부 미백용 약학 조성물을 제공한다.In addition, the present invention provides a pharmaceutical composition for skin whitening comprising an extract of Palidajaju chicken ( Tradescantia pallida ) as an active ingredient.
또한, 본 발명은 팔리다자주닭개비(Tradescantia pallida) 추출물을 유효성분으로 포함하는 피부 미백용 건강식품 조성물을 제공한다.In addition, the present invention provides a health food composition for skin whitening comprising an extract of Palidajaju chicken ( Tradescantia pallida ) as an active ingredient.
또한, 본 발명은 팔리다자주닭개비(Tradescantia pallida) 추출물을 유효성분으로 포함하는 티로시나아제 활성 억제용 시약 조성물을 제공한다.In addition, the present invention provides a reagent composition for inhibiting tyrosinase activity comprising an extract of Tradescantia pallida as an active ingredient.
본 발명에 따르면, 팔리다자주닭개비 추출물은 항산화능, 티로시나아제 활성 저해능을 나타내어 피부 미백 효과가 우수한 바, 피부 미백용 화장료 조성물, 피부 미백용 약학 조성물, 피부 미백용 건강식품 조성물 등으로 유용하게 활용될 수 있다.According to the present invention, the Palidajaju chicken gaebi extract exhibits antioxidant activity and tyrosinase activity inhibitory activity, so it has excellent skin whitening effect, and is useful as a cosmetic composition for skin whitening, a pharmaceutical composition for skin whitening, a health food composition for skin whitening, etc. Can be utilized.
도 1은 팔리다자주닭개비 추출물의 총 폴리페놀 함량을 확인한 것이다.
도 2는 팔리다자주닭개비 추출물의 총 플라보노이드 함량을 확인한 것이다.
도 3은 팔리다자주닭개비 추출물의 전자공여능을 확인한 것이다.
도 4는 팔리다자주닭개비 추출물의 티로시나아제 활성 저해능을 확인한 것이다.Figure 1 is a check of the total polyphenol content of the Palidajaju chicken gaebi extract.
Figure 2 is to confirm the total flavonoid content of the extract of Palidajaju chicken gaebi.
Figure 3 is to confirm the electron donating ability of Palidajaju chicken gaebi extract.
Figure 4 is to confirm the tyrosinase activity inhibitory ability of the extract of Pali dajaju chicken gaebi.
본 발명의 발명자들은 에탄올, 메탄올 또는 에틸아세테이트를 이용하여 팔리다자주닭개비 추출물을 제조하였으며, 상기 추출물의 항산화능, 티로시나아제 활성 저해능으로부터 피부 미백 효과를 확인하며 본 발명의 완성하였다.The inventors of the present invention prepared an extract of Palidajaju chicken gaebi using ethanol, methanol or ethyl acetate, and confirmed the skin whitening effect from the antioxidant activity and tyrosinase activity inhibition activity of the extract, and completed the present invention.
이에, 본 본 발명은 팔리다자주닭개비(Tradescantia pallida) 추출물을 유효성분으로 포함하는 피부 미백용 화장료 조성물을 제공한다.Accordingly, the present invention provides a cosmetic composition for skin whitening comprising an extract of Palidajaju chicken ( Tradescantia pallida ) as an active ingredient.
상기 추출물은 에탄올, 메탄올 및 에틸아세테이트로 이루어진 군에서 선택된 어느 하나 이상의 용매로 추출될 수 있으나, 이에 제한되는 것은 아님을 명시한다.The extract may be extracted with any one or more solvents selected from the group consisting of ethanol, methanol, and ethyl acetate, but it is specified that the extract is not limited thereto.
상기 추출물은 총 조성물 100 중량부에 대하여 0.001 내지 50 중량부로 포함될 수 있으나, 이에 제한되는 것은 아님을 명시한다.It should be noted that the extract may be included in an amount of 0.001 to 50 parts by weight based on 100 parts by weight of the total composition, but is not limited thereto.
상기 추출물은 티로시나아제의 활성을 저해하여 색소 침착을 개선하고 피부 미백 효과를 나타낼 수 있다.The extract may improve pigmentation by inhibiting the activity of tyrosinase and exhibit a skin whitening effect.
본 발명의 조성물이 화장료 조성물인 경우, 상기 화장료 조성물은 상기 유효성분 외에 안정화제, 용해화제, 비타민, 안료 및 향료와 같은 통상적인 보조제, 그리고 담체를 포함할 수 있다. 또한, 상기 화장료 조성물은 그 효과를 증진시키기 위해 피부 흡수 촉진제를 추가로 포함할 수 있다.When the composition of the present invention is a cosmetic composition, the cosmetic composition may include conventional auxiliary agents such as stabilizers, solubilizers, vitamins, pigments and fragrances, and a carrier in addition to the active ingredients. In addition, the cosmetic composition may further include a skin absorption accelerator to enhance its effect.
상기 화장료 조성물의 제형은 당업계에서 통상적으로 제조되는 어떠한 제형으로도 제조될 수 있으며, 예를 들어, 화장료 조성물은 화장수, 유액, 스킨, 토너, 로션, 에센스, 선 스크린, 크림, 메이크업 베이스, 파운데이션, 파우더, 팩, 젤, 연고, 패치, 스틱, 샴푸, 린스, 스프레이, 메이크업 제거제 및 세정제 등으로 제형화 될 수 있으나, 이에 한정되는 것은 아님을 명시한다.The formulation of the cosmetic composition may be prepared in any formulation conventionally prepared in the art, for example, the cosmetic composition is a lotion, emulsion, skin, toner, lotion, essence, sunscreen, cream, makeup base, foundation , Powder, pack, gel, ointment, patch, stick, shampoo, rinse, spray, makeup remover and detergent, etc. may be formulated, but is not limited thereto.
상기 제형이 페이스트, 크림 또는 겔인 경우에는 담체 성분으로서 동물성유, 식물성유, 왁스, 파라핀, 전분, 트라칸트, 셀룰로오스 유도체, 폴리에틸렌 글리콜, 실리콘, 벤토나이트, 실리카, 탈크 또는 산화아연 등이 이용될 수 있다.When the formulation is a paste, cream or gel, animal oil, vegetable oil, wax, paraffin, starch, tracant, cellulose derivatives, polyethylene glycol, silicone, bentonite, silica, talc, or zinc oxide may be used as a carrier component. .
상기 제형이 파우더 또는 스프레이인 경우에는 담체 성분으로서 락토스, 탈크, 실리카, 알루미늄 히드록시드, 칼슘 실리케이트 또는 폴리아미드 파우더가 이용될 수 있고, 특히 스프레이인 경우에는 추가적으로 클로로플루오로히드로카본, 프로판/부탄 또는 디메틸 에테르와 같은 추진체를 포함할 수 있다.When the formulation is a powder or spray, lactose, talc, silica, aluminum hydroxide, calcium silicate or polyamide powder may be used as a carrier component, and in particular, in the case of a spray, additional chlorofluorohydrocarbon, propane/butane Or a propellant such as dimethyl ether.
상기 제형이 용액 또는 유탁액인 경우에는 담체 성분으로서 용매, 용해화제 또는 유탁화제가 이용되고, 예컨대 물, 에탄올, 이소프로판올, 에틸 카보네이트, 에틸 아세테이트, 벤질 알코올, 벤질 벤조에이트, 프로필렌 글리콜, 1,3-부틸글리콜 오일, 글리세롤 지방족 에스테르, 폴리에틸렌 글리콜 또는 소르비탄의 지방산 에스테르가 있다.When the formulation is a solution or emulsion, a solvent, a solubilizing agent or an emulsifying agent is used as a carrier component, such as water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene glycol, 1,3 -Butyl glycol oil, glycerol aliphatic ester, polyethylene glycol or fatty acid ester of sorbitan.
상기 제형이 현탁액인 경우에는 담체 성분으로서 물, 에탄올 또는 프로필렌 글리콜과 같은 액상의 희석제, 에톡실화 이소스테아릴 알코올, 폴리옥시에틸렌 소르비톨 에스테르 및 폴리옥시에틸렌 소르비탄 에스테르와 같은 현탁제, 미소결정성 셀룰로오스, 알루미늄 메타히드록시드, 벤토나이트, 아가 또는 트라칸트 등이 이용될 수 있다.When the above formulation is a suspension, a liquid diluent such as water, ethanol or propylene glycol as a carrier component, an ethoxylated isostearyl alcohol, a suspending agent such as polyoxyethylene sorbitol ester and polyoxyethylene sorbitan ester, microcrystalline cellulose , Aluminum metahydroxide, bentonite, agar or tracant, and the like may be used.
또한, 본 발명은 팔리다자주닭개비(Tradescantia pallida) 추출물을 유효성분으로 포함하는 피부 미백용 약학 조성물을 제공한다.In addition, the present invention provides a pharmaceutical composition for skin whitening comprising an extract of Palidajaju chicken ( Tradescantia pallida ) as an active ingredient.
본 발명의 조성물이 약학 조성물인 경우, 투여를 위하여, 상기 기재한 유효성분 이외에 약학적으로 허용 가능한 담체, 부형제 또는 희석제를 포함할 수 있다. 상기 담체, 부형제 및 희석제로는 락토오스, 덱스트로오스, 수크로오스, 소르비톨, 만니톨, 자일리톨, 에리스리톨, 말티톨, 전분, 아카시아 고무, 알지네이트, 젤라틴, 칼슘 포스페이트, 칼슘 실리케이트, 셀룰로오스, 메틸 셀룰로오스, 미정질 셀룰로오스, 폴리비닐피롤리돈, 물, 메틸히드록시벤조에이트, 프로필히드록시벤조에이트, 탈크, 마그네슘 스테아레이트 및 광물유를 들 수 있다.When the composition of the present invention is a pharmaceutical composition, for administration, it may include a pharmaceutically acceptable carrier, excipient, or diluent in addition to the above-described active ingredients. Examples of the carrier, excipient and diluent include lactose, dextrose, sucrose, sorbitol, mannitol, xylitol, erythritol, maltitol, starch, gum acacia, alginate, gelatin, calcium phosphate, calcium silicate, cellulose, methyl cellulose, microcrystalline cellulose, Polyvinylpyrrolidone, water, methylhydroxybenzoate, propylhydroxybenzoate, talc, magnesium stearate, and mineral oils.
본 발명의 약학 조성물은 각각 통상의 방법에 따라 산제, 과립제, 정제, 캡슐제, 현탁액, 에멀젼, 시럽, 에어로졸 등의 경구형 제형, 외용제, 좌제 또는 멸균 주사용액의 형태로 제형화하여 사용할 수 있다. 상세하게는 제형화할 경우 통상 사용하는 충진제, 중량제, 결합제, 습윤제, 붕해제, 계면활성제 등의 희석제 또는 부형제를 사용하여 조제될 수 있다. 경구투여를 위한 고형 제제로는 정제, 환제, 산제, 과립제, 캡슐제 등을 포함하나, 이에 한정되는 것은 아니다. 이러한 고형 제제는 상기 유효성분 외에 적어도 하나 이상의 부형제, 예를 들면, 전분, 칼슘 카보네이트, 수크로오스, 락토오스, 젤라틴 등을 섞어 조제될 수 있다. 또한, 단순한 부형제 이외에 마그네슘 스테아레이트, 탈크 같은 윤활제들도 사용될 수 있다. 경구를 위한 액상물, 리퀴드 파라핀 이외에 여러 가지 부형제, 예를 들면 습윤제, 감미제, 방향제, 보존제 등을 첨가하여 조제될 수 있다. 비경구 투여를 위한 제제는 멸균된 수용액, 비수성 용제, 현탁제, 유제, 동결건조 제제 및 과제를 포함한다. 비수성 용제 및 현탁제로는 프로필렌글리콜, 폴리에틸렌글리콜, 올리브 오일과 같은 식물성 오일, 에틸올레이트와 같은 주사 가능한 에스테르 등이 사용될 수 있다. 좌제의 기제로는 위텝솔, 마크로솔, 트윈 61, 카카오지, 라우린지, 글리세로젤라틴 등이 사용될 수 있다.The pharmaceutical compositions of the present invention can be formulated and used in the form of oral dosage forms such as powders, granules, tablets, capsules, suspensions, emulsions, syrups, aerosols, etc., external preparations, suppositories, or sterile injectable solutions according to a conventional method. . Specifically, when formulated, it may be prepared using diluents or excipients such as fillers, weight agents, binders, wetting agents, disintegrants, and surfactants that are commonly used. Solid preparations for oral administration include, but are not limited to, tablets, pills, powders, granules, capsules, and the like. Such a solid preparation may be prepared by mixing at least one excipient, for example, starch, calcium carbonate, sucrose, lactose, gelatin, etc. in addition to the active ingredient. Further, in addition to simple excipients, lubricants such as magnesium stearate and talc may also be used. It can be prepared by adding various excipients, such as wetting agents, sweetening agents, fragrances, preservatives, and the like, in addition to oral liquids and liquid paraffin. Formulations for parenteral administration include sterilized aqueous solutions, non-aqueous solvents, suspensions, emulsions, lyophilized formulations, and tasks. As the non-aqueous solvent and suspending agent, propylene glycol, polyethylene glycol, vegetable oils such as olive oil, injectable esters such as ethyloleate, and the like may be used. As a base for suppositories, witepsol, macrosol, Tween 61, cacao butter, laurin, glycerogelatin, and the like can be used.
본 발명의 약학 조성물의 적합한 투여량은 환자의 상태 및 체중, 질병의 정도, 약물형태, 시간에 따라 다르지만, 당 업자에 의해 적절하게 선택될 수 있는 바, 상기 조성물의 일일 투여량은 바람직하게는 0.001 mg/kg 내지 50 mg/kg이며, 필요에 따라 일일 1회 내지 수회로 나누어 투여할 수 있다.A suitable dosage of the pharmaceutical composition of the present invention varies depending on the condition and weight of the patient, the severity of the disease, the form of the drug, and the time, but may be appropriately selected by a person skilled in the art, and the daily dosage of the composition is preferably It is 0.001 mg/kg to 50 mg/kg, and it can be administered once to several times a day as needed.
또한, 본 발명은 팔리다자주닭개비(Tradescantia pallida) 추출물을 유효성분으로 포함하는 피부 미백용 건강식품 조성물을 제공한다.In addition, the present invention provides a health food composition for skin whitening comprising an extract of Palidajaju chicken ( Tradescantia pallida ) as an active ingredient.
본 발명의 조성물이 건강식품 조성물인 경우, 여러 가지 영양제, 비타민, 광물(전해질), 합성 풍미제 및 천연 풍미제 등의 풍미제, 착색제 및 중진제(치즈, 초콜릿 등), 펙트산 및 그의 염, 알긴산 및 그의 염, 유기산, 보호성 콜로이드 증점제, pH 조절제, 안정화제, 방부제, 글리세린, 알코올, 탄산음료에 사용되는 탄산화제 등을 함유할 수 있다. 그 밖에 천연 과일 주스, 합성 과일 주스 및 야채 음료의 제조를 위한 과육을 함유할 수 있다. 이러한 성분은 독립적으로 또는 조합하여 사용할 수 있다. 또한, 건강식품 조성물은 육류, 소세지, 빵, 초콜릿, 캔디류, 스넥류, 과자류, 피자, 라면, 껌류, 아이스크림류, 스프, 음료수, 차, 기능수, 드링크제, 알코올 및 비타민 복합제 중 어느 하나의 형태일 수 있다.When the composition of the present invention is a health food composition, various nutrients, vitamins, minerals (electrolytes), flavoring agents such as synthetic flavoring agents and natural flavoring agents, coloring agents and thickening agents (cheese, chocolate, etc.), pectic acid and salts thereof , Alginic acid and salts thereof, organic acids, protective colloidal thickeners, pH adjusters, stabilizers, preservatives, glycerin, alcohols, carbonates used in carbonated beverages, and the like. In addition, it may contain pulp for the manufacture of natural fruit juices, synthetic fruit juices and vegetable beverages. These components may be used independently or in combination. In addition, the health food composition may be in the form of any one of meat, sausage, bread, chocolate, candy, snacks, confectionery, pizza, ramen, gum, ice cream, soup, beverage, tea, functional water, drink, alcohol and vitamin complex. I can.
또한, 상기 건강식품 조성물은 식품첨가물을 추가로 포함할 수 있으며, 식품첨가물로서의 적합 여부는 다른 규정이 없는 한 식품의약품안전처에 승인된 식품첨가물공전의 총칙 및 일반 시험법 등에 따라 해당 품목에 관한 규격 및 기준에 의하여 판정한다.In addition, the health food composition may additionally contain food additives, and the suitability as a food additive is determined according to the general rules and general test methods of the Food Additive Code approved by the Ministry of Food and Drug Safety, unless otherwise specified. It is judged according to standards and standards.
상기 식품첨가물공전에 수재된 품목으로 예를 들어, 케톤류, 글리신, 구연산 칼륨, 니코틴산, 계피산 등의 화학적 합성품, 감색소, 감초추출물, 결정셀룰로오스, 고랭색소, 구아검 등의 천연첨가물, L-글루타민산나트륨 제제, 면류 첨가 알칼리제, 보존료제제, 타르색소 제제 등의 혼합 제제류 등을 들 수 있다.For example, ketones, glycine, potassium citrate, nicotinic acid, chemical synthetic products such as cinnamic acid, dark pigment, licorice extract, crystalline cellulose, high cooling pigment, natural additives such as guar gum, L-glutamic acid And mixed preparations such as sodium preparations, noodle-added alkali preparations, preservative preparations, and tar color preparations.
이때, 건강식품 조성물을 제조하는 과정에서 식품에 첨가되는 본 발명에 따른 조성물은 필요에 따라 그 함량을 적절히 가감할 수 있다.At this time, the composition according to the present invention added to the food in the process of manufacturing the health food composition can be appropriately added or subtracted, if necessary.
또한, 본 발명은 팔리다자주닭개비(Tradescantia pallida) 추출물을 유효성분으로 포함하는 티로시나아제 활성 억제용 시약 조성물을 제공한다.In addition, the present invention provides a reagent composition for inhibiting tyrosinase activity comprising an extract of Tradescantia pallida as an active ingredient.
이하에서는 실시예를 통하여 본 발명을 더욱 상세히 설명하고자 한다. 이들 실시예는 오로지 본 발명을 보다 구체적으로 설명하기 위한 것으로, 본 발명의 요지에 따라 본 발명의 범위가 이들 실시예에 의해 제한되지 않는다는 것은 당업계에서 통상의 지식을 가진 자에 있어서 자명할 것이다.Hereinafter, the present invention will be described in more detail through examples. These examples are only for describing the present invention in more detail, and it will be apparent to those of ordinary skill in the art that the scope of the present invention is not limited by these examples according to the gist of the present invention. .
실시예 1: 시약 및 기기Example 1: Reagents and instruments
페놀(Folin & Ciocalteu's phenol reagent), 디메틸 설폭사이드(dimethyl sulfoxide; DMSO), 다이에틸렌 글라이콜(diethylene glycol), 과황산칼륨(potassium potroxodisulfate), 1,1-디페닐-2-피크릴하이드라질(1,1-diphenyl-2-picrylhydrazyl; DPPH), 탄닌산(tannic acid), 루틴(rutin), 티로신(tyrosine), 티로시나아제(from mushroom)는 Sigma 사(St. Louis, MO, USA)의 제품을 사용하였으며, 그 외 일반시약들은 특급품을 사용하였다. Phenol (Folin & Ciocalteu's phenol reagent), dimethyl sulfoxide (DMSO), diethylene glycol, potassium persulfate (potassium potroxodisulfate), 1,1-diphenyl-2-picrylhydrazyl (1,1-diphenyl-2-picrylhydrazyl; DPPH), tannic acid, rutin, tyrosine, and tyrosinase from mushroom are manufactured by Sigma (St. Louis, MO, USA). The product was used, and other general reagents used a special product.
실시예 2: 팔리다자주닭개비 추출물 제조Example 2: Palidajaju chicken gaebi extract preparation
팔리다자주닭개비(T. pallida) 추출물을 제조하기 위해, 제주대학교 생명자원과학대학 유리온실 내에 생육 중인 팔리다자주닭개비의 지상부를 채취하여 건조기에서 건조하였다. 건조시킨 팔리다자주닭개비를 믹서기로 분쇄하고 500 μm 체로 거른 다음 10 g당 100 mL의 에탄올, 메탄올 또는 에틸아세테이트로 24시간씩 2회 반복추출 후 감압농축기로 농축하였다. 완전농축이 안된 시료는 동결건조기로 건조하여 각각 팔리다자주닭개비 에탄올추출물(T. pallida ethanol extract; TPEE), 팔리다자주닭개비 메탄올추출물(T. pallida methanol extract; TPME), 팔리다자주닭개비 에틸아세테이트추출물(T. pallida ethyl acetate extract; TPAE) 시료를 제조하였다. 이후 시료는 DMSO에 녹인 다음 증류수로 1000 μg/mL에서 62.5 μg/mL까지 희석한 후 실험에 사용하였다.To prepare the extract of Palidajaju chicken ( T. pallida ), the above-ground part of Palidajaju chicken gaebi growing in the glass greenhouse of the College of Life Science and Resources at Cheju National University was collected and dried in a dryer. The dried Palidajaju chicken gaebi was pulverized with a blender, filtered through a 500 μm sieve, extracted twice for 24 hours with 100 mL of ethanol, methanol or ethyl acetate per 10 g, and then concentrated with a reduced pressure concentrator. Samples that have not been completely concentrated are dried with a freeze dryer and sold separately by T. pallida ethanol extract (TPEE), T. pallida methanol extract (TPME), and ethyl acetate. An extract ( T. pallida ethyl acetate extract; TPAE) sample was prepared. Thereafter, the sample was dissolved in DMSO, diluted from 1000 μg/mL to 62.5 μg/mL with distilled water, and used in the experiment.
실시예 3: 항산화능 분석Example 3: Analysis of antioxidant activity
1) 총 폴리페놀 함량 분석1) Analysis of total polyphenol content
총 폴리페놀 함량은 Folin-Denis법(Folin & Denis, 1912)으로 측정하였다. 200 μg/mL 농도로 희석한 시료 1 mL에 folin-reagent 1 mL를 가하고 실온에서 3분간 반응시킨 후 10% Na2CO3 1 mL를 가하고 실온에서 1시간 방치하였다. 이후 725 nm에서 흡광도를 측정하였다. 검량곡선은 탄닌산을 이용하여 작성하였다.Total polyphenol content was measured by the Folin-Denis method (Folin & Denis, 1912). 1 mL of folin-reagent was added to 1 mL of the sample diluted to a concentration of 200 μg/mL, reacted at room temperature for 3 minutes, 1 mL of 10% Na 2 CO 3 was added, and left at room temperature for 1 hour. Then, the absorbance was measured at 725 nm. The calibration curve was prepared using tannic acid.
그 결과, 도 1과 같이 총 폴리페놀 함량은 TPEE의 경우 298.7 tannic acid equivalent(TAE) mg/g, TPME의 경우 418.4 TAE mg/g, TPAE의 경우 430.1 TAE mg/g임을 확인하였다. As a result, as shown in FIG. 1, the total polyphenol content was 298.7 tannic acid equivalent (TAE) mg/g for TPEE, 418.4 TAE mg/g for TPME, and 430.1 TAE mg/g for TPAE.
2) 총 플라보노이드 함량2) Total flavonoid content
총 플라보노이드 함량은 Davies et al.(1980)의 변법으로 측정하였다. 200 μg/mL 농도로 희석한 시료 100 μL에 다이에틸렌 글라이콜 1 mL를 가하고 실온에서 5분간 반응시킨 후 1 N NaOH 용액 100 μL를 가하고 37℃에서 1시간 방치하였다. 이후 420 nm에서 흡광도를 측정하였다. 검량곡선은 루틴을 사용하여 작성하였다.The total flavonoid content was measured by a variant of Davies et al. (1980). 1 mL of diethylene glycol was added to 100 μL of a sample diluted to a concentration of 200 μg/mL, reacted for 5 minutes at room temperature, and then 100 μL of a 1 N NaOH solution was added and left at 37°C for 1 hour. Then, the absorbance was measured at 420 nm. The calibration curve was prepared using a routine.
그 결과, 도 2와 같이 총 플라보노이드의 함량은 TPEE의 경우 180.5 rutin equivalent(RE) mg/g, TPME의 경우 247.1 RE mg/g, TPAE의 경우 359.1 RE mg/g임을 확인하였다. As a result, as shown in FIG. 2, it was confirmed that the total flavonoid content was 180.5 rutin equivalent (RE) mg/g for TPEE, 247.1 RE mg/g for TPME, and 359.1 RE mg/g for TPAE.
3) 전자공여능(DPPH 라디칼 소거능)3) Electron donating ability (DPPH radical scavenging ability)
전자공여능은 Blois(1958)의 방법으로 측정하였다. 96-웰 플레이트에 에탄올에 녹인 0.2 mM DPPH 용액 50 μL와 팔리다자주닭개비 추출물을 62.5, 125, 250, 500, 1000 μg/mL 농도로 각각 100 μL씩 가하고 차광 상태에서 30분 동안 방치한 후 517 nm에서 흡광도를 측정하였다. GraphPrism 소프트웨어 Ver. 7(Graphpad Software, lnc., La Jolla, CA, USA)을 사용하여 SC50(50% scavenging concentration, 자유라디칼을 50% 소거하는 농도)을 산출하였다.The electron donating ability was measured by the method of Blois (1958). To a 96-well plate, 50 μL of 0.2 mM DPPH solution dissolved in ethanol and 100 μL of Palidajaju chicken gaebi extract at 62.5, 125, 250, 500, and 1000 μg/mL concentrations were added each, and allowed to stand for 30 minutes in a light-shielded state. The absorbance was measured at nm. GraphPrism software Ver. 7 (Graphpad Software, lnc., La Jolla, CA, USA) was used to calculate SC 50 (50% scavenging concentration, 50% free radical scavenging concentration).
그 결과, 도 3과 같이 팔리다자주닭개비 추출물은 농도 의존적으로 정적(+)인 용량-반응 상관관계를 나타내었으며, 양성대조군인 아스코르브산(ascorbic acid; AA)과 TPEE, TPME, TPAE 추출물에 대한 전자공여능은 1000 μg/mL에서 각각 97.5, 70.4, 66.7, 91.9%임을 확인하였다. SC50을 산출한 결과, TPEE, TPME, TPAE 추출물에 대한 SC50은 664.8, 660.8, 277.3 μg/mL이었다. AA의 SC50은 산출되지 않았으나 125 μg/mL 보다 작은 것으로 확인되었다.As a result, as shown in Fig. 3, the Palidajaju chicken gaebi extract showed a positive (+) dose-response correlation in a concentration-dependent manner. It was confirmed that the electron donating ability was 97.5, 70.4, 66.7, and 91.9% at 1000 μg/mL, respectively. After calculating the SC 50, TPEE, TPME, SC 50 for TPAE extract was 664.8, 660.8, was 277.3 μg / mL. The SC 50 of AA was not calculated, but was found to be smaller than 125 μg/mL.
실시예 4: 효소활성 분석Example 4: Enzyme activity analysis
1) 머쉬룸(mushroom) 티로시나아제 활성 저해능1) Mushroom tyrosinase activity inhibition
62.5, 125, 250, 500, 1000 μg/mL 농도로 희석한 시료 5 μL와 인산나트륨(sodium phosphate) 버퍼(pH 6.8) 50 μL, 0.03% 티로신 50 μL, 머쉬룸 티로시나아제 10 μL를 혼합한 후 37℃에서 10분간 반응시켰다. 이후 얼음에서 5분간 냉각시킨 다음 475 nm에서 흡광도를 측정하였다. 양성대조군으로 알부틴(arbutin)을 사용하였다. GraphPrism 소프트웨어를 사용하여 IC50(50% inhibitory concentration, 티로시나아제 활성을 50% 저해하는 농도)을 산출하였다.After mixing 5 μL of the sample diluted to 62.5, 125, 250, 500, 1000 μg/mL, 50 μL of sodium phosphate buffer (pH 6.8), 50 μL of 0.03% tyrosine, and 10 μL of mushroom tyrosinase. It was reacted at 37°C for 10 minutes. After cooling for 5 minutes on ice, the absorbance was measured at 475 nm. Arbutin was used as a positive control. The IC 50 (50% inhibitory concentration, 50% inhibitory concentration of tyrosinase activity) was calculated using GraphPrism software.
그 결과, 도 4와 같이 팔리다자주닭개비 추출물은 농도 의존적으로 정적(+)인 용량-반응 상관관계를 나타내었으며, 양성대조군인 알부틴과 TPEE, TPME, TPAE 추출물에 대한 머쉬룸 티로시나아제 활성 저해능은 1000 μg/mL 농도에서 각각 62.7, 66.0, 68.2, 65.2%인 것을 확인하였다. 알부틴, TPEE, TPME, TPAE 추출물에 대한 IC50은 각각 437.7 287.7, 267.4, 343.2 μg/mL로 산출되었다. 즉, 팔리다자주닭개비 추출물은 양성대조군인 알부틴 보다 티로시나아제 활성 저해능이 우수한 것으로 나타났다.As a result, as shown in Fig. 4, the Palidajaju chicken gaebi extract showed a positive (+) dose-response correlation in a concentration-dependent manner, and the mushroom tyrosinase activity inhibitory ability against the positive control arbutin and TPEE, TPME, and TPAE extracts was It was confirmed that the concentrations were 62.7, 66.0, 68.2, and 65.2% at 1000 μg/mL concentration, respectively. IC 50 for arbutin, TPEE, TPME, and TPAE extracts were calculated as 437.7 287.7, 267.4 and 343.2 μg/mL, respectively. In other words, it was found that the Pali dajaju chicken gaebi extract was superior to the positive control, arbutin, to inhibit tyrosinase activity.
따라서 상기 결과들로부터 팔리다자주닭개비 추출물이 피부 착색을 효과적으로 저해하여 미백 효과를 나타낼 수 있음을 확인하였다. Therefore, from the above results, it was confirmed that the Palidajaju chicken gaebi extract can effectively inhibit skin pigmentation and exhibit a whitening effect.
이상으로 본 발명의 특정한 부분을 상세히 기술한 바, 당업계의 통상의 지식을 가진 자에게 있어서 이러한 구체적인 기술은 단지 바람직한 구현 예일 뿐이며, 이에 본 발명의 범위가 제한되는 것이 아닌 점은 명백하다. 따라서, 본 발명의 실질적인 범위는 첨부된 청구항과 그의 등가물에 의하여 정의된다고 할 것이다.As the specific parts of the present invention have been described in detail above, it is obvious that these specific techniques are only preferred embodiments, and the scope of the present invention is not limited thereto for those of ordinary skill in the art. Therefore, it will be said that the substantial scope of the present invention is defined by the appended claims and their equivalents.
본 발명의 범위는 후술하는 특허청구범위에 의하여 나타내어지며, 특허청구범위의 의미 및 범위 그리고 그 균등 개념으로부터 도출되는 모든 변경 또는 변형된 형태가 본 발명의 범위에 포함되는 것으로 해석되어야 한다.The scope of the present invention is indicated by the claims to be described later, and all changes or modified forms derived from the meaning and scope of the claims and their equivalent concepts should be interpreted as being included in the scope of the present invention.
Claims (7)
A reagent composition for inhibiting tyrosinase activity comprising an extract of Palidajaju chicken ( Tradescantia pallida ) as an active ingredient.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020190047350A KR102265918B1 (en) | 2019-04-23 | 2019-04-23 | Composition for skin whitening comprising Tradescantia pallida extract |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020190047350A KR102265918B1 (en) | 2019-04-23 | 2019-04-23 | Composition for skin whitening comprising Tradescantia pallida extract |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20200124020A true KR20200124020A (en) | 2020-11-02 |
| KR102265918B1 KR102265918B1 (en) | 2021-06-16 |
Family
ID=73397829
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020190047350A KR102265918B1 (en) | 2019-04-23 | 2019-04-23 | Composition for skin whitening comprising Tradescantia pallida extract |
Country Status (1)
| Country | Link |
|---|---|
| KR (1) | KR102265918B1 (en) |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101152326B1 (en) | 2004-10-22 | 2012-06-11 | 김원준 | A new composition for skin-whitening and wrinkle-care |
-
2019
- 2019-04-23 KR KR1020190047350A patent/KR102265918B1/en active IP Right Grant
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101152326B1 (en) | 2004-10-22 | 2012-06-11 | 김원준 | A new composition for skin-whitening and wrinkle-care |
Non-Patent Citations (1)
| Title |
|---|
| 김주성 외 1인, "팔리다자주닭개비 잎 추출물 및 분획물의 항산화 및 α-글루코시다아제 저해 활성", Korean J. Medicinal Crop Sci. 24(3) pp.222-227 (2016.)* * |
Also Published As
| Publication number | Publication date |
|---|---|
| KR102265918B1 (en) | 2021-06-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR102253376B1 (en) | Composition for improving winkle or skin whitening comprising atriplex gmelinii extract or paederia scandens extract | |
| KR102047234B1 (en) | Composition for Improving Skin Conditions with Improved Skin Whitening, Antioxidant, Moisturizing, Anti-wrinkling, and Regeneration Property Comprising Callus Extract of Hibiscus Syriacus | |
| US7189419B2 (en) | Use of active extracts to lighten skin, lips, hair, and/or nails | |
| KR101702138B1 (en) | Use of myrtle extract as depigmenting agent | |
| KR101131574B1 (en) | Composition for skin whitening | |
| KR101203504B1 (en) | Composition for Wrinkle-Care or Skin Whitening Containing Fermentation Liquor of Extract from Stewartia koreana | |
| KR101827655B1 (en) | A composition comprising banana having inhibitory effect on induction of grey hair and positive effect on induction of black hair | |
| KR102265918B1 (en) | Composition for skin whitening comprising Tradescantia pallida extract | |
| KR102236023B1 (en) | Composition for anti-wrinkle or skin whitening comprising Daphne kiusiana extract | |
| KR20090117364A (en) | Cosmetic composition for whitening of the skin comprising the extract of brucea javanica as active ingredient | |
| KR20230109286A (en) | Composition for protecting photo-damaged skin comprising extract of Kadsura coccinea | |
| KR102149223B1 (en) | Cosmetic composition for skin whitening containing the fermented complex natural extracts | |
| KR20210134589A (en) | Composition for improving skin comprising an extract of Pueraria thomsonii or a compound derived therefrom | |
| KR101551106B1 (en) | A composition comprising the extract of Paspalum thunbergii Kunth | |
| KR102277369B1 (en) | Composition for preventing or improving wrinkle comprising Tradescantia pallida extract | |
| KR20210004155A (en) | Composition for improving winkle or skin whitening comprising coreopsis lanceolate l. extract | |
| KR20170137405A (en) | Composition for improving skin condition comprising herb extracts mixture | |
| KR102214557B1 (en) | Cosmetic composition comprising dystaenia takeshimana extract | |
| KR102236021B1 (en) | Composition for skin whitening or improving winkle comprising hemiptelea davidii extract | |
| KR102236022B1 (en) | Composition for skin whitening or improving winkle comprising sonchus brachyotus extract | |
| KR102240026B1 (en) | Composition for skin whitening comprising Rhododendron schippenbachii root extract as effective component | |
| KR102412907B1 (en) | Composition for skin whitening and improving skin wrinkle comprising Codonopsis lanceolata bud extract as an active ingredient | |
| KR102246588B1 (en) | Composition for skin whitening or improving winkle comprising rhamnus davurica extract | |
| KR102459512B1 (en) | Method for preparing complex extracts of neungi, chrysanthemum, and magnolia using Cyclodextrin Glucanotransferas and cosmetic composition containing the same | |
| KR102220580B1 (en) | Cosmetic composition containing botanical extract complex |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| E902 | Notification of reason for refusal | ||
| E601 | Decision to refuse application | ||
| X091 | Application refused [patent] | ||
| AMND | Amendment | ||
| E902 | Notification of reason for refusal | ||
| AMND | Amendment | ||
| X701 | Decision to grant (after re-examination) | ||
| GRNT | Written decision to grant |