KR20200104706A - Multilayer Coating Soft Capsule - Google Patents
Multilayer Coating Soft Capsule Download PDFInfo
- Publication number
- KR20200104706A KR20200104706A KR1020190023388A KR20190023388A KR20200104706A KR 20200104706 A KR20200104706 A KR 20200104706A KR 1020190023388 A KR1020190023388 A KR 1020190023388A KR 20190023388 A KR20190023388 A KR 20190023388A KR 20200104706 A KR20200104706 A KR 20200104706A
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- KR
- South Korea
- Prior art keywords
- soft capsule
- coated
- weight
- red ginseng
- parts
- Prior art date
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- 238000002137 ultrasound extraction Methods 0.000 description 1
- 229960005486 vaccine Drugs 0.000 description 1
- 239000008371 vanilla flavor Substances 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- 235000019166 vitamin D Nutrition 0.000 description 1
- 239000011710 vitamin D Substances 0.000 description 1
- 150000003710 vitamin D derivatives Chemical class 0.000 description 1
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Images
Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/30—Encapsulation of particles, e.g. foodstuff additives
- A23P10/35—Encapsulation of particles, e.g. foodstuff additives with oils, lipids, monoglycerides or diglycerides
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P20/00—Coating of foodstuffs; Coatings therefor; Making laminated, multi-layered, stuffed or hollow foodstuffs
- A23P20/10—Coating with edible coatings, e.g. with oils or fats
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P20/00—Coating of foodstuffs; Coatings therefor; Making laminated, multi-layered, stuffed or hollow foodstuffs
- A23P20/10—Coating with edible coatings, e.g. with oils or fats
- A23P20/15—Apparatus or processes for coating with liquid or semi-liquid products
- A23P20/18—Apparatus or processes for coating with liquid or semi-liquid products by spray-coating, fluidised-bed coating or coating by casting
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2250/00—Food ingredients
- A23V2250/20—Natural extracts
- A23V2250/21—Plant extracts
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2250/00—Food ingredients
- A23V2250/20—Natural extracts
- A23V2250/21—Plant extracts
- A23V2250/2124—Ginseng
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- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
Description
본 발명은 다중 코팅된 연질 캡슐에 관한 것이다.The present invention relates to a multi-coated soft capsule.
캡슐화란 내부 물질을 고분자막으로 감싸거나 코팅하는 것을 말한다. 캡슐의 외막은 캡슐 내에 포함된 내부 물질이 산소에 노출되는 것을 차단하여 내부 물질을 보호함으로써 내부 물질을 안정하게 유지시키고, 방출 제어하는 역할을 한다. 내부 물질은 액체, 고체가 적용될 수 있고, 기체도 적용 가능하다. 내부 물질이 액상일 경우에는 다른 활성 성분이 용해 또는 분산될 수 있다. 내부 물질로는 화장품, 약품, 백신, 효소, 미생물, 세포, 향, 오일, 살충제, 색소 등이 적용될 수 있고, 희석제와 같은 첨가제 또는 안정제가 추가로 첨가될 수 있다. Encapsulation refers to wrapping or coating the inner material with a polymer film. The outer film of the capsule protects the inner material by blocking exposure of the inner material contained in the capsule to oxygen, thereby stably maintaining the inner material and controlling its release. Liquid and solid can be applied to the inner material, and gas can be applied. When the inner material is liquid, other active ingredients may be dissolved or dispersed. Cosmetics, drugs, vaccines, enzymes, microorganisms, cells, flavors, oils, insecticides, pigments, and the like may be applied as internal substances, and additives such as diluents or stabilizers may be additionally added.
캡슐의 외막을 구성하는 성분은 원하는 두께로 내부 물질을 포매하였을 때에 안정적인 물질이 주로 사용되고 있다. 외막 성분에는 주로 비활성 고분자, 유연제, 보습제, 색소, 방출 속도 조절제가 포함된다. 예를 들면, 알지네이트, 젤라틴, 카라기난, 셀룰로오스 설페이트, 키토산이 이용되고 있다.As a component constituting the outer film of the capsule, a stable material is mainly used when the inner material is embedded in a desired thickness. Outer membrane components mainly include inert polymers, softeners, moisturizers, pigments, and release rate modifiers. For example, alginate, gelatin, carrageenan, cellulose sulfate, and chitosan are used.
캡슐은 사용처에 따라서 정확성, 적시성, 안전성, 편리성, 기능성, 시각적 효과의 기능을 갖는다. 특히 식품 분야에서 캡슐 제형이 이용될 때에는 기능성, 편리성 효과가 중요하다. 식품의 경우에는 캡슐 내에 포함되는 유효 성분의 생리 활성이 유지되어야 하며, 캡슐끼리 접착하여 덩어리지지 않으면 섭취가 편하고, 이에 따라 상품성도 높아지므로, 기능성과, 섭취 편의성을 충족시킬 수 있는 캡슐 제형에 대한 연구가 필요한 실정이다. Capsules have functions of accuracy, timeliness, safety, convenience, functionality, and visual effects depending on the application. In particular, when the capsule formulation is used in the food field, the functionality and convenience are important. In the case of food, the physiological activity of the active ingredient contained in the capsule must be maintained, and if the capsules are adhered to each other and are not lumped, it is convenient to intake, and accordingly, the marketability is increased, so that the capsule formulation that can satisfy the functionality and convenience of intake Research is needed.
캡슐의 종류로서는 심리스 캡슐(seamless capsule)과 심타입 캡슐(seam type capsule)이 있다. 심리스 캡슐은 적하 방식으로 제조되며, 내부 물질과 외막을 구성하는 성분을 포함하는 용액이 노즐을 통해 방출되면서 구형의 캡슐이 형성되며, 외막을 구성하는 성분으로는 젤라틴, 아가, 천연 겔화 물질 등이 사용되고, 외막은 열, 산, 저온에 내성이 있다. 심타입 캡슐의 경우에는 수상과 유상의 반발력을 이용하여 펌핑 방식으로 제조된다. 구체적으로 내부 물질(유상)을 밀어내고, 내부 물질이 노즐을 통해 나오는 순간 수상 물질에 노출되면서 유상의 반발력에 의해 겔화 피막 물질이 유상을 구형으로 감싸면서 제조된다. 외막을 구성하는 성분으로 젤라틴, 글리세린 등이 사용되며, 외막은 기능이 없는 것으로 알려져 있다.Types of capsules include a seamless capsule and a seam type capsule. Seamless capsules are manufactured by dropping method, and a spherical capsule is formed as a solution containing the components constituting the inner material and the outer film is discharged through the nozzle, and as the ingredients constituting the outer film, gelatin, agar, natural gelling material, etc. Used, and the outer film is resistant to heat, acid, and low temperatures. In the case of a shim type capsule, it is manufactured in a pumping method using the repulsive force of the water phase and oil phase. Specifically, the inner material (oil phase) is pushed out and the inner material is exposed to the water phase material as soon as it comes out through the nozzle, and the gelling film material surrounds the oil phase in a spherical shape by the repulsive force of the oil phase. Gelatin, glycerin, etc. are used as components of the outer membrane, and the outer membrane is known to have no function.
심리스 캡슐은 심타입 캡슐에 비해서, 투명하고 광택이 있는 구형의 캡슐이 제조되고, 지용성 성분을 직접적으로 캡슐화할 수 있으며, 캡슐 자체의 크기를 감소/증가시켜서 내부 물질의 용량을 조절할 수 있다. 또한, 내부 물질의 산화를 막기 때문에 방습벽(vapor barrier) 기능도 한다. 외막을 구성하는 성분을 포함하는 용액에 다양한 색소를 첨가함으로써 색상을 다양하게 하여 캡슐의 외관을 미려하게 할 수 있다. 또한, 직경을 1mm 내지 8mm 사이의 범위 내에서 자유롭게 조절이 가능하여 캡슐의 쓰임에 맞도록 직경을 조절할 수 있다. Compared to the shim type capsule, the seamless capsule is a transparent and glossy spherical capsule, and can directly encapsulate the fat-soluble component, and the capacity of the internal material can be adjusted by reducing/increasing the size of the capsule itself. It also functions as a vapor barrier because it prevents oxidation of internal materials. By adding various pigments to the solution containing the components constituting the outer film, the appearance of the capsule can be made beautiful by varying the color. In addition, the diameter can be freely adjusted within the range of 1mm to 8mm, so that the diameter can be adjusted to suit the use of the capsule.
심리스 캡슐 제조시에는 특허문헌 1에 개시된 캡슐 제조 장치를 사용할 수 있다. 상기 제조 장치는 향액(내부 물질)이 배출되는 경로와, 막재(외막을 구성하는 성분이 포함된 용액)가 배출되는 경로가 각각 있는 이중 배출 구조를 갖는다. 또한 막재가 향액을 감싸는 형태로 배출되어 향 캡슐의 초기 형태를 형성하는 노즐을 가지며, 노즐의 하단에 냉각재가 투입되면서, 막재가 향액을 감싼 형태가 냉각되어 캡슐이 제조된다. 그러나, 특허문헌 1에서는 담배의 향을 적재하기 위한 캡슐 제조에 대해서만 개시되어 있을 뿐, 식품 분야에 적용가능한 캡슐의 제조에 대해서는 개시되어 있지 않다. 또한, 캡슐의 사용처에 따라 각각의 기능성 요소들을 충족해야 하므로, 특허문헌 1에 개시된 캡슐 제조 장치를 이용하여 화장품에 적용가능한 캡슐을 제조하고자 할 때에는 외막에 포함되는 성분, 또는 내부 물질에 대한 검토가 추가적으로 필요하다. 또한, 특허문헌 1에서 사용되는 캡슐은 건조 공정과 추가 경화 과정을 포함하고 있어 외막이 단단한 하드 캡슐이므로 식품에 적용하기에는 어려움이 있었다.When manufacturing a seamless capsule, the capsule manufacturing apparatus disclosed in patent document 1 can be used. The manufacturing apparatus has a dual discharge structure in which there are a path through which a fragrance (internal substance) is discharged, and a path through which makjae (a solution containing a component constituting the outer film) is discharged. In addition, the makjae has a nozzle that forms the initial shape of the scent capsule by being discharged in a form surrounding the scented liquid, and as the coolant is introduced into the lower end of the nozzle, the makjae wrapped around the scented liquid is cooled to produce a capsule. However, Patent Literature 1 discloses only the manufacture of capsules for loading the flavor of tobacco, and the manufacture of capsules applicable to the food field is not disclosed. In addition, since each functional element must be satisfied according to the usage of the capsule, in order to manufacture a capsule applicable to cosmetics using the capsule manufacturing apparatus disclosed in Patent Document 1, it is necessary to review the ingredients included in the outer membrane or the inner material. Additionally needed. In addition, since the capsule used in Patent Document 1 includes a drying process and an additional curing process, it is difficult to apply it to food because the outer film is hard capsule.
유동층 코팅 기술은 건조된 고형 원료를 단순히 혼합하고 결합하는 분무 건조 방식으로, 유동층 코팅 기술로 미세한 과립, 과립, 구슬 모양의 비드(bead) 타입의 제형이 제조된다. 이와 같이 종래의 유동층 코팅 기술은 고형 원료를 대상으로 하였기 때문에 오일류 또는 착향료 고유의 특징을 유지한 상태로 액상 원료의 사용이 어려워서 차나, 건강 식품 등의 다양한 제품 개발에 한계가 있었고, 소비자 요구에 부응하기 어려웠다. 또한, 입자 크기가 큰 비드 타입 제조시에는 유동층 기기를 장시간 운용함으로써 임가공비가 증가되어 생산성이 떨어지고 제품 가격이 상승되는 요인이 되어 왔다. The fluidized bed coating technology is a spray drying method that simply mixes and combines dried solid raw materials. The fluidized bed coating technology produces fine granules, granules, and bead-type formulations. As described above, since the conventional fluidized bed coating technology targets solid raw materials, it is difficult to use liquid raw materials while maintaining the characteristic characteristics of oils or flavoring agents, so there has been a limit to the development of various products such as tea and health foods, and meets consumer needs. It was difficult to do. In addition, when manufacturing a bead type having a large particle size, the processing cost is increased by operating the fluidized bed device for a long time, resulting in a decrease in productivity and an increase in product price.
본 발명의 목적은 오일류 또는 착향료와 같은 액상 원료의 고유 특성을 유지하면서도, 최종 제조된 가공물간에 접착이 없는 캡슐을 제공하는 것이다.An object of the present invention is to provide a capsule without adhesion between the final manufactured processed products while maintaining the intrinsic properties of liquid raw materials such as oils or flavoring agents.
상기 과제를 해결하기 위하여, 본 발명은 액상 원료를 포함하는 연질 캡슐; 연질 캡슐의 표면에 코팅되는 홍삼 추출물로 이루어진 1차 코팅물; 및 1차 코팅물의 표면에 코팅되는 홍삼 분말로 이루어진 2차 코팅물;로 이루어진 다중 코팅된 연질 캡슐을 제공한다.In order to solve the above problems, the present invention is a soft capsule containing a liquid raw material; Primary coating consisting of red ginseng extract coated on the surface of the soft capsule; It provides a multi-coated soft capsule consisting of; and a secondary coating consisting of red ginseng powder coated on the surface of the primary coating.
본 발명의 다중 코팅된 소형 연질 캡슐은 연질 캡슐 내에 충전된 오일류, 착향류 등의 액상 원료의 고유 특성을 유지하면서도 다중 코팅된 소형 연질 캡슐끼리간에 접착이 없어서 섭취가 용이하다. 또한, 코팅시 사용된 홍삼 성분으로 홍삼의 생리활성 효과도 얻을 수 있다.The multi-coated small soft capsule of the present invention maintains the intrinsic properties of liquid raw materials such as oils and flavors filled in the soft capsule, but is easy to ingest because there is no adhesion between the multi-coated small soft capsules. In addition, it is possible to obtain the physiologically active effect of red ginseng with the red ginseng component used during coating.
도 1은 소형 연질 캡슐을 나타낸다.
도 2는 1차 코팅만 수행한 소형 연질 캡슐(대조군), 및 1차 및 2차 코팅 모두 수행한 소형 연질 캡슐(시험군)의 노출 시간에 따른 10메쉬 체 통과 비율을 나타낸다.
도 3은 1차 코팅만 수행한 소형 연질 캡슐(대조군), 및 1차 및 2차 코팅 모두 수행한 소형 연질 캡슐(시험군)의 노출 시간에 따른 캡슐간 접착 정도를 나타낸다. 1 shows a small soft capsule.
FIG. 2 shows the 10 mesh sieve rate according to the exposure time of the small soft capsule (control group) in which only the first coating was performed, and the small soft capsule (test group) in which both the first and second coating were performed.
3 shows the degree of adhesion between capsules according to exposure time of the small soft capsules (control group) in which only the first coating was performed, and the small soft capsules (test group) in which both the first and second coatings were performed.
이하, 본 발명을 상세하게 설명한다.Hereinafter, the present invention will be described in detail.
본 발명은 액상 원료를 포함하는 연질 캡슐; 연질 캡슐의 표면에 코팅되는 홍삼 추출물로 이루어진 1차 코팅물; 및 1차 코팅물의 표면에 코팅되는 홍삼 분말로 이루어진 2차 코팅물;로 이루어진 다중 코팅된 연질 캡슐을 제공한다.The present invention is a soft capsule containing a liquid raw material; Primary coating consisting of red ginseng extract coated on the surface of the soft capsule; It provides a multi-coated soft capsule consisting of; and a secondary coating consisting of red ginseng powder coated on the surface of the primary coating.
상기 액상 원료는 오일일 수 있고, 오일 베이스의 액상 원료라면 제한없이 적용할 수 있다. 상기 오일은 식품에 사용되는 오일 성분일 수 있다. 천연 식물성 오일 또는 식물성 공급원으로부터 얻어지는 가공 오일일 수 있다. 또는 천연 동물성 오일 또는 동물성 공급원으로부터 얻어지는 가공 오일일 수 있다. 예를 들면, 상기 오일은 식품 및 건강기능식품으로 사용되는 착향료 또는 식용오일류일 수 있다. 예를 들면, 코코넛유, 채종유, 땅콩유, 올리브유, 동백유, 피마자유, 팜핵유, 대두유, 평지씨유, 해바라기유, 고-올레산 해바라기유, 옥수수유, 팜올레인유, 팜유, 홍화유, 고-올레산 홍화유, MCT 오일, 달맞이꽃 종자유, 들기름, 참기름, 아마인유, 미강유, 스쿠알렌, 정제어유, 미네랄오일, 홍삼 오일 및 이의 조합으로 이루어진 군으로부터 선택되는 어느 하나일 수 있다. The liquid raw material may be oil, and if it is an oil-based liquid raw material, it can be applied without limitation. The oil may be an oil component used in food. It may be a natural vegetable oil or a processed oil obtained from a vegetable source. Or natural animal oils or processed oils obtained from animal sources. For example, the oil may be flavoring or edible oils used as foods and health functional foods. For example, coconut oil, rapeseed oil, peanut oil, olive oil, camellia oil, castor oil, palm kernel oil, soybean oil, rapeseed oil, sunflower oil, high-oleic sunflower oil, corn oil, palm olein oil, palm oil, safflower oil, high- It may be any one selected from the group consisting of oleic safflower oil, MCT oil, evening primrose oil, perilla oil, sesame oil, linseed oil, rice bran oil, squalene, refined fish oil, mineral oil, red ginseng oil, and combinations thereof.
상기 액상 원료에 착향료 및 지용성 비타민 중 적어도 하나를 추가로 포함할 수 있으며, 오일류에 쉽게 용해되고, 기능성이 있는 원료라면 제한없이 포함될 수 있다. The liquid raw material may further include at least one of a flavoring agent and a fat-soluble vitamin, and any raw material that is easily soluble in oils and has functionality may be included without limitation.
상기 착향료는 식품의 향을 살려주는 역할을 한다. 본 발명에 적용될 수 있는 착향료는 식품 조성물에 포함되는 것이라면 제한없이 사용할 수 있다. 천연착향료 또는 합성 착향료가 사용될 수 있다. 예를 들면, 딸기향, 바나나향, 페퍼민트향, 계피향, 레몬향, 라즈베리향, 블루베리향, 커피향, 애플민트향, 매실향, 믹스후르츠향, 애플향, 멘톨향 및 바닐라향으로 이루어진 군으로부터 선택되는 하나일 수 있다.The flavoring agent serves to save the flavor of food. Flavoring agents that can be applied to the present invention can be used without limitation as long as they are included in the food composition. Natural flavors or synthetic flavors can be used. For example, strawberry flavor, banana flavor, peppermint flavor, cinnamon flavor, lemon flavor, raspberry flavor, blueberry flavor, coffee flavor, apple mint flavor, plum flavor, mixed fruit flavor, apple flavor, menthol flavor and vanilla flavor It may be one selected from the group.
상기 지용성 비타민은 지방 또는 지방을 녹이는 유기용매에 녹는 비타민으로서 본 발명에서 특별히 제한되지 않으며, 구체적으로 비타민 A, 비타민 D, 비타민 E, 비타민 F, 비타민 K, 비타민 U 및 이의 조합으로 이루어지는 군으로부터 선택되는 하나일 수 있다. The fat-soluble vitamin is a vitamin that is soluble in fat or an organic solvent that dissolves fat, and is not particularly limited in the present invention, and is specifically selected from the group consisting of vitamin A, vitamin D, vitamin E, vitamin F, vitamin K, vitamin U, and combinations thereof. It can be one that becomes.
상기 연질 캡슐의 직경은 1 mm 내지 10 mm, 1 mm 내지 9 mm, 1 mm 내지 8 mm, 1 mm 내지 7 mm, 1 mm 내지 6 mm일 수 있으나, 이에 한정하지 않는다. 연질 캡슐의 직경이 하한값 미만일 경우에는 캡슐의 크기가 너무 작아서 다중 코팅시, 섭취시에 손실되는 양이 많아진다. 연질 캡슐의 직경이 상한값을 초과할 경우에는 유동층 기기로 코팅이 어려울 수 있다. The diameter of the soft capsule may be 1 mm to 10 mm, 1 mm to 9 mm, 1 mm to 8 mm, 1 mm to 7 mm, 1 mm to 6 mm, but is not limited thereto. When the diameter of the soft capsule is less than the lower limit, the size of the capsule is too small, and the amount lost during multiple coating and ingestion increases. If the diameter of the soft capsule exceeds the upper limit, it may be difficult to coat with a fluid bed device.
상기 연질 캡슐의 피막은 글리세린, 한천, 펙틴, 스테비올 배당체 및 알긴산나트륨을 포함하는 피막제가 경화된 것일 수 있다. 피막제는 피막이 굳기 전에 피막을 이루는 성분의 혼합물을 나타내며, 위 성분 외에 정제수가 포함될 수 있다. 피막제 100중량부 기준으로 글리세린은 1 중량부 내지 10 중량부, 한천은 1 중량부 내지 10 중량부, 펙틴은 1 중량부 내지 10 중량부, 스테비올 배당체는 0.1 중량부 내지 5 중량부, 알긴산나트륨은 0.1 중량부 내지 5중량부로 포함될 수 있으나, 이에 한정하지 않는다. The film of the soft capsule may be cured with a film containing glycerin, agar, pectin, steviol glycoside, and sodium alginate. The coating agent refers to a mixture of components that form the coating before the coating is hardened, and purified water may be included in addition to the above components. Based on 100 parts by weight of the coating agent, glycerin is 1 to 10 parts by weight, agar is 1 to 10 parts by weight, pectin is 1 to 10 parts by weight, steviol glycoside is 0.1 to 5 parts by weight, sodium alginate May be included in an amount of 0.1 to 5 parts by weight, but is not limited thereto.
피막제 100 중량부 기준으로 상기 글리세린은 2 중량부 내지 9 중량부, 3 중량부 내지 8 중량부, 4 중량부 내지 7 중량부, 4 중량부 내지 6 중량부로 포함될 수 있다. 피막제 100 중량부 기준으로 한천은 2 중량부 내지 9 중량부, 2 중량부 내지 8 중량부, 2 중량부 내지 7 중량부, 2 중량부 내지 6 중량부, 2 중량부 내지 5 중량부, 2 중량부 내지 4 중량부로 포함될 수 있다. 피막제 100 중량부 기준으로 펙틴은 1 중량부 내지 8 중량부, 1 중량부 내지 7 중량부, 1 중량부 내지 5 중량부, 1 중량부 내지 4 중량부, 1 중량부 내지 3 중량부로 포함될 수 있다. 피막제 100 중량부 기준으로 스테비올 배당체는 0.5 중량부 내지 5 중량부, 0.5 중량부 내지 4 중량부, 0.5 중량부 내지 3 중량부, 0.7 중량부 내지 2 중량부, 0.7 중량부 내지 1 중량부로 포함될 수 있다. 피막제 100 중량부 기준으로 알긴산나트륨은 0.1 중량부 내지 4중량부, 0.1 중량부 내지 3중량부, 0.1 중량부 내지 2중량부, 0.1 중량부 내지 1중량부로 포함될 수 있으나, 이에 한정하지 않는다. 아울러, 피막제에는 상기 성분 외에 물을 첨가할 수 있다. 상기 피막제에 포함되는 성분의 함량이 상기 범위를 만족하지 않는 경우에는 피막제의 점도가 피막을 형성하기에 적합하지 않고, 이에 따라 연질 캡슐을 제조하여도 피막이 완전히 굳지 않게 된다. 피막이 굳지 않으면 피막 내의 액상 원료가 누출될 수 있고, 1차, 2차 코팅을 할 수 없다. Based on 100 parts by weight of the coating agent, the glycerin may be included in an amount of 2 to 9 parts by weight, 3 to 8 parts by weight, 4 to 7 parts by weight, and 4 to 6 parts by weight. Based on 100 parts by weight of the coating agent, agar is 2 parts by weight to 9 parts by weight, 2 parts by weight to 8 parts by weight, 2 parts by weight to 7 parts by weight, 2 parts by weight to 6 parts by weight, 2 parts by weight to 5 parts by weight, 2 parts by weight It may be included in parts to 4 parts by weight. Pectin may be included in 1 to 8 parts by weight, 1 to 7 parts by weight, 1 to 5 parts by weight, 1 to 4 parts by weight, 1 to 3 parts by weight based on 100 parts by weight of the coating agent. . Based on 100 parts by weight of the coating agent, the steviol glycoside is included in 0.5 parts by weight to 5 parts by weight, 0.5 parts by weight to 4 parts by weight, 0.5 parts by weight to 3 parts by weight, 0.7 parts by weight to 2 parts by weight, 0.7 parts by weight to 1 part by weight. I can. Sodium alginate may be included in an amount of 0.1 to 4 parts by weight, 0.1 to 3 parts by weight, 0.1 to 2 parts by weight, and 0.1 to 1 part by weight based on 100 parts by weight of the coating agent, but is not limited thereto. In addition, water may be added to the coating agent in addition to the above components. When the content of the component contained in the coating agent does not satisfy the above range, the viscosity of the coating agent is not suitable for forming a coating, and thus, the coating is not completely hardened even when a soft capsule is manufactured. If the film is not hardened, the liquid raw material in the film may leak, and the primary and secondary coating cannot be performed.
상기 피막제의 점도는 300cps 내지 850cps, 350cps 내지 800cps, 400cps 내지 750cps, 450cps 내지 700cps, 500cps 내지 650cps일 수 있고, 이에 한정하지 않는다. 점도가 하한값 미만일 경우에는 캡슐 성형이 어렵다. 점도가 상한값을 초과할 경우에는 캡슐 제조시, 캡슐 제조 장치 내의 피막제가 배출되는 노즐에서 피막제의 배출이 용이하지 않아 캡슐의 제조가 어려워진다. 또한, 피막제는 45℃ 내지 80℃, 예컨대 50℃ 내지 75℃, 55℃ 내지 70℃, 60℃ 내지 65℃에서 보관될 수 있다. 피막제 보관 온도가 상기 범위를 벗어나는 경우에는 피막제가 굳거나, 피막제가 변질될 수 있다. The viscosity of the coating agent may be 300cps to 850cps, 350cps to 800cps, 400cps to 750cps, 450cps to 700cps, 500cps to 650cps, but is not limited thereto. When the viscosity is less than the lower limit, it is difficult to mold the capsule. When the viscosity exceeds the upper limit, it is difficult to discharge the coating agent from the nozzle through which the coating agent is discharged in the capsule manufacturing apparatus during capsule manufacturing, making it difficult to manufacture the capsule. In addition, the coating agent may be stored at 45 ℃ to 80 ℃, such as 50 ℃ to 75 ℃, 55 ℃ to 70 ℃, 60 ℃ to 65 ℃. When the storage temperature of the coating agent is outside the above range, the coating agent may be hardened or the coating agent may be deteriorated.
인삼(Panax ginseng)은 식물 분류학상으로 오갈피나무과(Araliaceae)의 인삼속(Panax)에 속하는 다년생 음지성 초본식물로서 오래 전부터 한방에서 중요한 약재로 사용되었다. 인삼은 일반적으로 가공 방법에 따라 백삼과 홍삼으로 구분되며, 백삼은 밭에서 채굴한 가공되지 아니한 인삼 즉, 수삼을 그대로 건조한 것을 지칭하며 홍삼은 수삼을 증숙하여 건조 가공한 것으로 제조 과정에서 사포닌 변형과 아미노산 변화 등 여러 화학적인 변화가 수반된다. 홍삼은 제조 과정에서 가해지는 열에 의해 인삼에 존재하지 않는 진세노사이드 Rg2, Rg3, Rh1, Rh2 등의 사포닌 성분이 생성되며, 홍삼 특유의 유효 성분은 암 예방 작용, 암세포 성장 억제 작용, 혈압 강하 작용, 뇌신경세포 보호 및 학습 능력 개선 작용, 항혈전 작용, 항산화 작용 등이 우수하다. Panax ginseng is a perennial dark herbaceous plant belonging to the genus Panax of the Araliaceae family, and has been used as an important medicinal material in oriental medicine for a long time. Ginseng is generally classified into white ginseng and red ginseng according to the processing method, and white ginseng refers to unprocessed ginseng mined in the field, that is, fresh ginseng as it is dried, and red ginseng is dried and processed by steaming fresh ginseng. Several chemical changes are involved, including amino acid changes. Red ginseng produces saponin components such as ginsenosides Rg2, Rg3, Rh1, and Rh2, which are not present in ginseng by the heat applied during the manufacturing process, and the unique active ingredient of red ginseng has cancer prevention, cancer cell growth, and blood pressure reduction. , It is excellent in protecting brain nerve cells and improving learning ability, antithrombotic action, and antioxidant action.
본 발명에 있어서, 추출물은 인삼의 잎, 어린 새싹, 본체, 본체 껍질, 줄기, 줄기 껍질, 뿌리, 뿌리 껍질, 뿌리줄기, 종자, 열매, 미숙과, 완숙과, 과육, 과피, 꽃, 수술군(androecium), 암술군(gynoecium), 꽃받침, 수술, 꽃잎, 꽃받침 조각, 심피 및 이들의 조합으로 이루어진 군으로부터 선택되는 어느 하나로부터 수득될 수 있다. 상기 뿌리줄기는 근경이라고도 하며, 줄기가 지하로 자라나 뿌리와 같은 역할을 하는 것을 나타낸다. 상기 수술군은 하나의 꽃에 있는 수술 전체를 나타내며, 상기 암술군은 하나의 꽃에 있는 암술 전체를 나타낸다. 상기 심피는 꽃의 암술을 만드는 구성요소로 일반적으로 화엽이라고 총칭되는 잎의 변형 형태를 나타낸다. 상기 인삼은 뿌리일 수 있으나, 이에 한정되지 아니하며, 인삼의 다른 부위에서 얻어진 추출물을 혼합하여 사용할 수 있다. In the present invention, the extract is ginseng leaves, young shoots, body, body bark, stem, stem bark, root, root bark, rhizome, seed, fruit, immature fruit, ripe fruit, pulp, pericarp, flower, stamen group (androecium), pistil group (gynoecium), it can be obtained from any one selected from the group consisting of calyx, stamen, petal, calyx piece, carpel, and combinations thereof. The rhizome is also referred to as rhizome, and indicates that the stem grows underground and acts like a root. The stamen group represents all stamens in one flower, and the pistil group represents all pistils in one flower. The carpel is a component that makes pistils of flowers, and generally represents a modified form of leaves, which are collectively referred to as flower leaves. The ginseng may be a root, but is not limited thereto, and extracts obtained from different parts of ginseng may be mixed and used.
본 발명에서 일컫는 "추출물"은 원료로부터 임의의 방법으로 추출된 물질을 의미하며, 이렇게 추출된 추출액, 이로부터 얻을 수 있는 농축액, 상기 농축액의 건조물 및 분말을 제한 없이 모두 포함하는 의미로 사용된다.The term "extract" as referred to in the present invention refers to a material extracted from a raw material by any method, and is used to include all of the extracted extract, the concentrate obtainable therefrom, the dried product and powder of the concentrate without limitation.
상기 추출물은 원료 또는 이의 건조물로부터 추출하여 얻을 수 있으며, 상기 추출물의 원료는 재배한 것 또는 시판되는 것 등 제한 없이 사용할 수 있다.The extract may be obtained by extracting from a raw material or a dried product thereof, and the raw material of the extract may be used without limitation, such as cultivated or commercially available ones.
상기 추출물을 원료로부터 추출하여 수득할 때, 추출 방법으로는 용매 추출법, 초음파 추출법, 여과법 및 환류 추출법 등 종래 알려진 통상적인 추출 방법을 모두 사용할 수 있으며, 바람직하게는 용매 추출법이나 환류 추출법을 이용함으로써 제조할 수 있다. 상기 추출 과정은 수회 반복할 수 있으며, 이후에 농축 또는 동결건조 등의 단계를 추가적으로 거칠 수 있다. 구체적으로, 수득한 추출물을 감압 농축하여 농축액을 얻고, 상기 농축액을 동결건조시킨 후 분쇄기를 이용하여 고농도의 추출 분말을 제조할 수 있다. 추출물은 추출물을 추가적으로 분획하여 얻은 분획물도 포함한다. When the extract is obtained by extracting from the raw material, all conventionally known extraction methods such as solvent extraction method, ultrasonic extraction method, filtration method and reflux extraction method can be used as the extraction method, and it is preferably prepared by using a solvent extraction method or a reflux extraction method. can do. The extraction process may be repeated several times, and thereafter may be additionally subjected to steps such as concentration or freeze-drying. Specifically, the obtained extract is concentrated under reduced pressure to obtain a concentrate, the concentrate is freeze-dried, and then a high-concentration extract powder can be prepared using a grinder. The extract also includes a fraction obtained by further fractionating the extract.
상기 추출물은 물, 유기용매 또는 이들의 혼합물을 추출용매로 하여 추출될 수 있다. 상기 유기용매는 알코올, 바람직하게는 C1-C4의 저급 알코올, 헥산(n-헥산), 에테르, 글리세롤, 프로필렌글리콜, 부틸렌글리콜, 에틸아세테이트, 메틸아세테이트, 디클로로메탄, 클로로포름, 에틸아세테이트, 벤젠 및 이들의 혼합용매로 이루어지는 군으로부터 선택되는 어느 하나일 수 있다. 물 및 유기용매의 혼합물을 추출 용매로 사용하는 경우, 물 및 유기용매의 혼합물은 바람직하게는 물 및 C1-C4의 저급 알코올의 혼합물일 수 있고, 더욱 바람직하게는 물일 수 있다.The extract may be extracted using water, an organic solvent, or a mixture thereof as an extraction solvent. The organic solvent is an alcohol, preferably a C 1 -C 4 lower alcohol, hexane (n-hexane), ether, glycerol, propylene glycol, butylene glycol, ethyl acetate, methyl acetate, dichloromethane, chloroform, ethyl acetate, It may be any one selected from the group consisting of benzene and a mixed solvent thereof. When a mixture of water and an organic solvent is used as the extraction solvent, the mixture of water and an organic solvent may preferably be a mixture of water and a lower alcohol of C 1 -C 4 , and more preferably water.
상기 홍삼 추출물은 20 Brix 내지 70 Brix, 25 Brix 내지 65 Brix, 30 Brix 내지 60 Brix, 35 Brix 내지 55 Brix, 40 Brix 내지 50 Brix일 수 있으나, 이에 한정하지 않는다. 홍삼 추출물의 당도가 하한값 미만이면 홍삼 추출물로 1차 코팅 후, 홍삼 분말로 2차 코팅할 때에 홍삼 분말이 연질 캡슐 표면에 코팅되지 않게 되어 다중 코팅된 연질 캡슐이라 하더라도 캡슐간의 접착이 여전히 남아있게 된다. 홍삼 추출물의 당도가 상한값을 초과하면 홍삼 추출물의 점도가 높아지기 때문에 유동층 기기로 분무시에 분무가 어려울 수 있다.The red ginseng extract may be 20 Brix to 70 Brix, 25 Brix to 65 Brix, 30 Brix to 60 Brix, 35 Brix to 55 Brix, 40 Brix to 50 Brix, but is not limited thereto. If the sugar content of the red ginseng extract is less than the lower limit, the red ginseng powder is not coated on the surface of the soft capsule when the red ginseng extract is first coated and then the red ginseng powder is second coated, so that even in the case of a multi-coated soft capsule, the adhesion between the capsules still remains. . If the sugar content of the red ginseng extract exceeds the upper limit, the viscosity of the red ginseng extract increases, so it may be difficult to spray when spraying with a fluid bed device.
상기 홍삼 추출물의 진세노사이드 Rg1, Rb1, Rg3의 합은 1 mg/g 이상, 예컨대 1 mg/g 내지 15 mg/g, 1 mg/g 내지 10 mg/g, 1 mg/g 내지 7 mg/g, 3 mg/g 내지 6 mg/g일 수 있으나, 이에 한정하지 않는다. 진세노사이드 Rg1, Rb1, Rg3의 합이 하한값 미만일 경우에는 생리활성이 낮아질 수 있다.The sum of ginsenosides Rg1, Rb1, and Rg3 of the red ginseng extract is 1 mg/g or more, such as 1 mg/g to 15 mg/g, 1 mg/g to 10 mg/g, 1 mg/g to 7 mg/ g, 3 mg/g to 6 mg/g, but is not limited thereto. When the sum of ginsenosides Rg1, Rb1, and Rg3 is less than the lower limit, physiological activity may be lowered.
상기 홍삼 분말의 입도는 120 메쉬를 통과하는 분말이 60% 이상, 65% 이상, 70% 이상, 75% 이상, 80% 이상, 85% 이상, 90% 이상, 95% 이상일 수 있으나, 이에 한정하지 않는다. 상기 홍삼 분말의 입도가 하한값 미만일 경우에는 입도가 큰 홍삼 분말이 포함될 수 있고, 2차 코팅시에 캡슐 표면에 홍삼 분말이 균일하게 코팅되지 않을 수 있다. The particle size of the red ginseng powder may be 60% or more, 65% or more, 70% or more, 75% or more, 80% or more, 85% or more, 90% or more, 95% or more of the powder passing through 120 mesh, but is not limited thereto. Does not. When the particle size of the red ginseng powder is less than the lower limit, red ginseng powder with a large particle size may be included, and the red ginseng powder may not be uniformly coated on the capsule surface during the secondary coating.
상기 코팅은 유동층 기기를 이용하여 수행될 수 있다. 1, 2차 코팅시 분사량은 1ml/분 내지 20ml/분, 1ml/분 내지 15ml/분, 1ml/분 내지 10ml/분, 1ml/분 내지 8ml/분, 1ml/분 내지 6ml/분일 수 있다. 상기 분사량이 하한값 미만일 경우에는 코팅에 걸리는 시간이 길어질 수 있다. 상기 분사량이 상한값을 초과할 경우에는 분사된 코팅액이 건조되지 않고 젖은 상태로 존재하여 캡슐간 접착이 많아지고 접착된 상태로 고결되어 캡슐 자체의 무게가 증가하게 되므로 부양되지 않아 작은 구슬 타입으로 제형화되지 않는 문제점이 있다.The coating can be performed using a fluid bed device. In the first and second coating, the spraying amount may be 1ml/min to 20ml/min, 1ml/min to 15ml/min, 1ml/min to 10ml/min, 1ml/min to 8ml/min, 1ml/min to 6ml/min. When the injection amount is less than the lower limit, the time required for coating may be lengthened. If the amount of spraying exceeds the upper limit, the sprayed coating liquid is not dried but is present in a wet state, increasing adhesion between capsules, and solidifying the adhesive state, increasing the weight of the capsule itself, so it is not buoyed and formulated into a small bead type. There is a problem that does not work.
상기 연질 캡슐 50중량부에 대해서, 홍삼 추출물은 20 중량부 내지 60 중량부, 홍삼 분말 1 내지 20중량부로 포함될 수 있으나, 이에 한정하지 않는다. 상기 연질 캡슐 50중량부에 대해서, 홍삼 추출물은 25 중량부 내지 55 중량부, 30 중량부 내지 50 중량부, 35 중량부 내지 45 중량부로 포함될 수 있다. 상기 연질 캡슐 50중량부에 대해서, 홍삼 분말은 1 중량부 내지 15 중량부, 2 중량부 내지 13 중량부, 3 중량부 내지 11 중량부, 4 중량부 내지 9 중량부로 포함될 수 있다. 홍삼 추출물, 홍삼 분말의 첨가량이 상기 범위를 만족하지 않으면 다중 코팅된 연질 캡슐의 생리활성이 감소할 수 있고, 다중 코팅된 연질 캡슐의 경도가 낮아 외부 충격에 의해 액상 원료가 누출될 수 있다. With respect to 50 parts by weight of the soft capsule, the red ginseng extract may be included in an amount of 20 parts by weight to 60 parts by weight and 1 to 20 parts by weight of red ginseng powder, but is not limited thereto. With respect to 50 parts by weight of the soft capsule, the red ginseng extract may be included in an amount of 25 parts by weight to 55 parts by weight, 30 parts by weight to 50 parts by weight, and 35 parts by weight to 45 parts by weight. With respect to 50 parts by weight of the soft capsule, the red ginseng powder may be included in an amount of 1 to 15 parts by weight, 2 to 13 parts by weight, 3 to 11 parts by weight, and 4 to 9 parts by weight. If the amount of red ginseng extract and red ginseng powder added does not satisfy the above range, the physiological activity of the multi-coated soft capsule may decrease, and the hardness of the multi-coated soft capsule may be low, so that the liquid raw material may leak due to external impact.
1차 코팅물에 식물 추출물이 추가로 코팅될 수 있다. 식물 추출물이 추가로 코팅되는 경우 연질 캡슐 50중량부에 대해서, 식물 추출물은 1 중량부 내지 20 중량부, 예컨대 1 중량부 내지 15 중량부, 2 중량부 내지 13 중량부, 3 중량부 내지 11 중량부, 4 중량부 내지 9 중량부로 포함될 수 있다. Plant extracts may be further coated on the primary coating. When the plant extract is additionally coated, with respect to 50 parts by weight of the soft capsule, the plant extract is 1 part by weight to 20 parts by weight, such as 1 part by weight to 15 parts by weight, 2 parts by weight to 13 parts by weight, 3 parts by weight to 11 parts by weight It may be included in parts, 4 parts by weight to 9 parts by weight.
상기 식물 추출물은 감초, 당귀, 황기, 백작약, 백출, 숙지황, 천궁, 진피, 갈근, 맥문동, 두충, 산약, 우슬, 결명자, 원지, 생강, 대추, 구기자, 복분자, 천마, 오미자, 산수유 및 이의 조합으로 이루어진 군으로부터 선택되는 하나의 원료로부터 추출된 것일 수 있다. 상기의 식물 추출물은 예시한 것일 뿐이며, 식품 조성물에 사용되는 식물 추출물이라면 본 발명에 제한없이 적용할 수 있다. 추출시 사용되는 원료의 부위, 추출물의 정의, 추출 방법, 추출 용매는 상기에 기재한 바와 같으므로 설명을 생략한다. The plant extracts are Licorice, Angelica, Astragalus, Baekchul, Sukjihwang, Cheongung, Dermis, Galgeun, Maekmundong, Duchung, Sanyak, Useul, Cassia tora, Wonji, Ginger, Jujube, Gugija, Bokbunja, Cheonma, Schisandra, Cornus and a combination thereof It may be extracted from one raw material selected from the group consisting of. The above plant extracts are only illustrative, and any plant extracts used in food compositions can be applied without limitation to the present invention. The part of the raw material used for extraction, the definition of the extract, the extraction method, and the extraction solvent are the same as described above, so the description is omitted.
상기 식물 추출물은 식물 추출물을 동결건조하여 수득한 분말 형태일 수 있다.The plant extract may be in the form of a powder obtained by lyophilizing the plant extract.
상기 다중 코팅된 연질 캡슐의 경도는 0.5KP 내지 5KP, 예컨대 0.7KP 내지 4.5KP, 0.9KP 내지 4KP, 1.2KP 내지 3.5KP, 1.5KP 내지 3.5KP일 수 있으나, 이에 한정되지 않는다. 상기 경도가 하한값 미만일 경우에는 연질 캡슐 내의 액상 원료가 누출될 수 있다. 상기 경도가 상한값을 초과할 경우에는 저작하기에 어려워 식품으로 섭취하기 어려울 수 있다.The hardness of the multi-coated soft capsule may be 0.5KP to 5KP, such as 0.7KP to 4.5KP, 0.9KP to 4KP, 1.2KP to 3.5KP, 1.5KP to 3.5KP, but is not limited thereto. When the hardness is less than the lower limit, the liquid raw material in the soft capsule may leak. If the hardness exceeds the upper limit, it may be difficult to chew and ingest as food.
본 발명의 한 실시예에서는 MCT 오일, 페퍼민트향, 비타민E를 포함하는 충전물과, 글리세린, 한천, 펙틴, 스테비올 배당체, 알긴산 나트륨 및 정제수를 포함하는 피막제를 이용하여 연질 캡슐을 제조하였다. 제조된 연질 캡슐의 표면에 45 Brix인 홍삼 추출물을 유동층 기기를 사용하여, 분사량을 2ml/분으로 분사하여 1차 코팅물을 생성하였다. 그 후, 1차 코팅된 연질 캡슐에 120메쉬 체를 통과하는 분말이 85% 이상인 입도를 가지는 홍삼 분말을 유동층 기기를 사용하여 분사량 5ml/분으로 분사하여 2차 코팅물을 생성하였다. 제조된 다중 코팅된 연질 캡슐은 홈, 주름, 무늬, 갈라짐이 없고, 고유의 색택과 향미를 가지며, 경도가 2KP 이상이었고, 캡슐 내부의 액상 원료의 누출이 없었으며, 장시간 보관하여도 캡슐간 접착이 없었다.In one embodiment of the present invention, a soft capsule was prepared using a filler containing MCT oil, peppermint flavor, and vitamin E, and a coating agent containing glycerin, agar, pectin, steviol glycoside, sodium alginate, and purified water. A first coating was produced by spraying a 45 Brix red ginseng extract on the surface of the prepared soft capsule using a fluidized bed device, and spraying the spray amount at 2 ml/min. Thereafter, red ginseng powder having a particle size of 85% or more of the powder passing through the 120 mesh sieve in the first coated soft capsule was sprayed at a spraying amount of 5 ml/min using a fluidized bed device to create a second coating. The manufactured multi-coated soft capsule has no grooves, wrinkles, patterns, cracks, has a unique color and flavor, has a hardness of 2 KP or more, and there is no leakage of liquid raw materials inside the capsule, and adhesion between capsules even when stored for a long time There was no.
본 발명의 한 실시예에서는 MCT 오일, 페퍼민트향, 비타민E를 포함하는 충전물과, 글리세린, 한천, 펙틴, 스테비올 배당체, 알긴산 나트륨 및 정제수를 포함하는 피막제를 이용하여 연질 캡슐을 제조하였다. 제조된 연질 캡슐의 표면에 45 Brix인 홍삼 추출물에 식물 추출물 분말을 첨가하여 제조한 코팅액을 유동층 기기로 2ml/분으로 분사하여 1차 코팅물을 생성하였다. 그 후, 1차 코팅된 연질 캡슐에 120메쉬 체를 통과하는 분말이 85% 이상인 입도를 가지는 홍삼 분말을 유동층 기기를 사용하여 분사량 5ml/분으로 분사하여 2차 코팅물을 생성하였다. 제조된 다중 코팅된 연질 캡슐은 홈, 주름, 무늬, 갈라짐이 없고, 고유의 색택과 향미를 가지며, 경도가 2KP 이상이었고, 캡슐 내부의 액상 원료의 누출이 없었으며, 장시간 보관하여도 캡슐간 접착이 없었다.In one embodiment of the present invention, a soft capsule was prepared using a filler containing MCT oil, peppermint flavor, and vitamin E, and a coating agent containing glycerin, agar, pectin, steviol glycoside, sodium alginate, and purified water. A coating solution prepared by adding plant extract powder to a 45 Brix red ginseng extract on the surface of the prepared soft capsule was sprayed with a fluidized bed device at 2 ml/min to produce a first coating. Thereafter, red ginseng powder having a particle size of 85% or more of the powder passing through the 120 mesh sieve in the first coated soft capsule was sprayed at a spraying amount of 5 ml/min using a fluidized bed device to create a second coating. The manufactured multi-coated soft capsule has no grooves, wrinkles, patterns, cracks, has a unique color and flavor, has a hardness of 2 KP or more, and there is no leakage of liquid raw materials inside the capsule, and adhesion between capsules even when stored for a long time There was no.
본 발명에 따른 다중 코팅된 연질 캡슐은 연질 캡슐 내에 포함되는 액상 원료를 목적에 따라 변경함으로써 다양하게 응용할 수 있다. 예를 들면, 액상 원료로서 페퍼민트향, 레몬향을 넣음으로써 식사 또는 흡연 후에 구취를 방지할 수 있고, 액상 원료로 멘톨향을 넣음으로써 운전시에 졸음을 방지할 수 있다. The multi-coated soft capsule according to the present invention can be applied in various ways by changing the liquid raw material contained in the soft capsule according to the purpose. For example, by adding peppermint flavor and lemon flavor as a liquid raw material, bad breath can be prevented after eating or smoking, and drowsiness during driving can be prevented by adding menthol flavor as a liquid raw material.
이하, 본 발명을 제조예 및 실험예에 의해 상세히 설명한다.Hereinafter, the present invention will be described in detail with reference to Preparation Examples and Experimental Examples.
단, 하기 제조예 및 실험예는 본 발명을 예시하기 위한 것일 뿐, 본 발명의 내용이 하기 제조예 및 실험예에 의해 한정되는 것은 아니다.However, the following Preparation Examples and Experimental Examples are for illustrative purposes only, and the contents of the present invention are not limited by the following Preparation Examples and Experimental Examples.
제조예 1. 홍삼 분말의 제조Preparation Example 1. Preparation of red ginseng powder
건조된 홍삼(P. ginseng C.A. Meyer, 뿌리 70%, 잔미 30%)의 상태 및 이물 오염 여부를 점검하고, 세척수를 분사하여 세척하였다. 세척이 완료된 원료는 전용 선반에 적재하였다. 세척 완료된 원료를 습열기에 투입하고 다음의 원료별 조건으로 습열하였다. 홍삼근은 121±2℃에서 5분간 습열하고, 홍미삼은 121±1℃에서 1분간 습열하였다. 습열이 완료된 원료를 열풍건조실에 투입하고, 다음의 원료별 조건으로 건조하였다. 홍삼근은 60±3℃에서 72시간 동안 건조하고, 홍미삼은 60±3℃에서 48시간 동안 건조하였다. 건조 완료된 원료는 12시간 이상 방냉하였다. 건조 완료된 원료를 인수하고, 홍삼분쇄기를 체망 120메쉬로 설정하여 가동시킨 후 홍삼근 및 홍미삼을 적량씩 홍삼분쇄기에 투입하여 분쇄하였다. The dried red ginseng ( P. ginseng CA Meyer, root 70%, residual rice 30%) was checked for contamination and foreign matter contamination, and washed by spraying washing water. The raw materials that had been washed were loaded on a dedicated shelf. The washed raw material was put into a humidifier and wet-heated under the following conditions for each raw material. Red ginseng root was moist-heated at 121±2℃ for 5 minutes, and red ginseng was moist-heated at 121±1℃ for 1 minute. The moist-heated raw material was put into a hot air drying chamber, and dried under the following raw material conditions. Red ginseng root was dried at 60±3℃ for 72 hours, and red ginseng was dried at 60±3℃ for 48 hours. The dried raw material was allowed to cool for 12 hours or more. The dried raw materials were taken, and the red ginseng grinder was set to 120 mesh and operated, and then red ginseng roots and red rice ginseng were added in appropriate amounts to the red ginseng grinder and pulverized.
제조된 홍삼 분말은 연황색의 분말상으로 홍삼의 향미를 가지며, 이미, 이취가 없었다. 홍삼 성분(총 사포닌) 함량은 35 mg/g 이상이었고, 홍삼 분말의 입도는 120메쉬를 통과하는 분말이 85% 이상인 분말이었다. 수분은 4.3±1.0%이었으며 이물은 불검출되었다. The prepared red ginseng powder was a light yellow powder, and had the flavor of red ginseng, and had no off-flavor. The red ginseng component (total saponin) content was 35 mg/g or more, and the red ginseng powder had a particle size of 85% or more of the powder passing through 120 mesh. The moisture content was 4.3±1.0%, and no foreign matter was detected.
제조예 2. 홍삼 추출물의 제조Preparation Example 2. Preparation of red ginseng extract
건조된 홍삼(P. ginseng C.A. Meyer, 뿌리 75%, 잔미 25%) 500g에 6배의 증류수를 가해 85℃에서 10시간 추출하고 추출액을 여과하여 0~10℃로 냉각하였다. 잔사에 대해서는 6배의 증류수를 가해 10시간 추출을 1~4회 추가로 실시하여 추출액을 여과 후 모두 합하여 0~10℃로 냉각하였다. 냉각이 완료된 추출액을 4℃에서 10~20분 동안 6,000rpm으로 원심분리((주)한일사이메드, Supra 22K)하여 침전물을 제거하고 회전감압농축기(BUCHI, R-220)를 이용하여 50~60℃에서 71°Brix가 되도록 농축하여 홍삼 농축액을 제조하였다. 홍삼 농축액의 고형분 함량은 64%였다.To 500 g of dried red ginseng ( P. ginseng CA Meyer, root 75%, residue 25%), 6 times of distilled water was added and extracted at 85°C for 10 hours, and the extract was filtered and cooled to 0-10°C. Regarding the residue, 6 times of distilled water was added and extraction was further performed 1 to 4 times for 10 hours. The extract was filtered and then combined and cooled to 0 to 10°C. The cooled extract is centrifuged at 6,000 rpm for 10 to 20 minutes at 4℃ (Hanil Cymed Co., Ltd., Supra 22K) to remove the sediment, and 50 to 60 using a rotary vacuum concentrator (BUCHI, R-220). It was concentrated to 71 ° Brix at ℃ to prepare a red ginseng concentrate. The solid content of the red ginseng concentrate was 64%.
제조된 홍삼 농축액에 포함된 홍삼 성분의 함량은 수분 함량 40% 기준으로 환산시에 70.0 mg/g 이상이었고, 진세노사이드 Rg1, Rb1, Rg3의 합은 수분 함량 40% 기준으로 환산시에 5.5 mg/g 이상이었다. 홍삼 농축액은 암갈색이었으며, 이미, 이취가 없었다. The content of red ginseng components contained in the prepared red ginseng concentrate was 70.0 mg/g or more when converted based on a water content of 40%, and the sum of ginsenosides Rg1, Rb1, and Rg3 was 5.5 mg based on a water content of 40%. /g or more. The red ginseng concentrate was dark brown and had no off-flavor.
제조예 3. 감초 추출물 및, 이의 분말의 제조Preparation Example 3. Preparation of licorice extract and powder thereof
감초(Glycyrrhiza uralensis Fischer, Glycyrrhiza glabra Linne, 뿌리와 뿌리줄기) 1.0 kg에 중량 대비 13배수의 물을 가하고, 80℃에서 8시간 2회 추출하고 추출액을 5㎛ 필터를 이용하여 여과하였다. 여액은 회전감압농축기(BUCHI, R-220)를 이용하여 50~60℃에서 70°Brix가 되도록 농축하여 감초 농축액을 제조하였다. 감초 농축액을 동결건조(OPERON, FDT-12012)하여 감초 추출물 분말을 수득하였다. 13 times the weight of water was added to 1.0 kg of licorice ( Glycyrrhiza uralensis Fischer, Glycyrrhiza glabra Linne, roots and rhizomes), extracted twice at 80° C. for 8 hours, and the extract was filtered using a 5 μm filter. The filtrate was concentrated to 70° Brix at 50-60° C. using a rotary vacuum concentrator (BUCHI, R-220) to prepare a licorice concentrate. Licorice concentrate was freeze-dried (OPERON, FDT-12012) to obtain a licorice extract powder.
제조된 감초 추출물 분말의 성상은 밝은 노란색이었다.The properties of the prepared licorice extract powder were light yellow.
제조예 4. 소형 연질캡슐의 제조Preparation Example 4. Preparation of small soft capsule
건강기능식품공전, 식품공전, 식품첨가물공전에 정하는 적합한 원료를 구입하여서 기준 및 규격을 검사한 후 적합품만 사용하였다. 충전물과 피막은 하기 원료를 용해하여 배합하였다. After purchasing suitable raw materials specified in the Health Functional Food Code, Food Code, and Food Additive Code, only suitable products were used after checking the standards and specifications. The filling and the coating were mixed by dissolving the following raw materials.
표 1의 배합비로 배합된 피막은 점도가 600cps이었으며, 60℃에서 보관하였다. 캡슐의 제조는 한국 공개특허 제2016-0116827호에 개시된 캡슐 제조 장치를 이용하였다. 위 특허출원에는 캡슐에 포함되는 코어로서 향액이 개시되어 있고, 캡슐막으로는 막재가 개시되어 있으나, 본 발명에서는 상기 표 1 및 표 2의 성분을 이용하였다. 또한, 위 특허출원에는 노즐을 구비한 캡슐 제조 장치로 캡슐을 제조하여 건조하고, 추가로 경화함으로써 하드 캡슐을 제조하였으나, 본 발명에서는 건조 단계나, 추가 경화 단계를 제외함으로써 소프트 캡슐로 제조하였다. 제조된 소프트 캡슐은 하드 캡슐을 식용으로 하기에는 외막이 단단했던 것에 비해서 외막이 부드럽기 때문에 식용하기에 적절하였다. The film blended in the blending ratio of Table 1 had a viscosity of 600 cps, and was stored at 60°C. The capsule was manufactured using the capsule manufacturing apparatus disclosed in Korean Patent Application Publication No. 2016-0116827. In the above patent application, a fragrance is disclosed as a core contained in a capsule, and a makjae is disclosed as a capsule film, but the ingredients of Tables 1 and 2 are used in the present invention. In addition, in the above patent application, a capsule was manufactured by a capsule manufacturing apparatus equipped with a nozzle, dried, and further cured to prepare a hard capsule, but in the present invention, a soft capsule was manufactured by excluding a drying step or an additional curing step. The prepared soft capsule was suitable for edible use because the outer film was soft compared to the hard capsule having a hard outer film for edible use.
제조된 캡슐은 이음새가 없는 심리스(seamless) 형태의 캡슐이었으며, 투명하였다(도 1 참조). 제조된 캡슐의 크기는 현미경(Olympus SZ Luna) 및 ToupView(version x86) 프로그램을 이용하여 측정하였으며, 캡슐의 크기는 4 mm였다.The prepared capsule was a seamless capsule in the form of a seamless (seamless), and was transparent (see Fig. 1). The size of the prepared capsule was measured using a microscope (Olympus SZ Luna) and ToupView (version x86) program, and the size of the capsule was 4 mm.
제조예 5. 다중 코팅된 소형 연질 캡슐 제조Preparation Example 5. Preparation of multiple coated small soft capsules
소형 연질 캡슐 코팅시 사용된 원료의 배합비는 하기와 같다. The blending ratio of the raw materials used for coating small soft capsules is as follows.
5-1. 소형 연질 캡슐 1차 코팅5-1. Small soft capsule primary coating
1차 코팅은 코팅액을 사용하고, 유동층 코팅 방법으로 수행하였다. 코팅액으로는 제조예 2, 3에서 제조한 홍삼 농축액, 감초 추출물 분말을 사용하였다. 홍삼 농축액에 감초 추출물 분말을 녹여서 사용하였다. 씨드로는 제조예 4에서 제조한 소형 연질 캡슐을 사용하였다. 건조된 소형 연질 캡슐, 홍삼 농축액, 감초 추출물 분말의 비율은 5:4:0.5로 하였다. 제조예 2의 홍삼 농축액은 정제수를 넣어 당도를 45 Brix로 조정하였고, 교반기로 속도 55±5 RPM, 온도 40±5℃ 조건으로 교반하여 코팅액을 준비하였다. 코팅액이 준비되면, 캡슐을 유동층 기기(EG1 Lab-1, EG1 Co.,Ltd)에 시드로 투입 후 코팅기 온도를 40℃ 이하로 조절하였다. 코팅액을 2ml/분 양으로 분사하였다. 분사 완료한 후 40℃ 이하에서 20분 이상 건조하였다. The first coating was performed using a coating solution and a fluidized bed coating method. As a coating liquid, the red ginseng concentrate and licorice extract powder prepared in Preparation Examples 2 and 3 were used. Licorice extract powder was dissolved in red ginseng concentrate and used. As a seed, a small soft capsule prepared in Preparation Example 4 was used. The ratio of dried small soft capsules, red ginseng concentrate, and licorice extract powder was 5:4:0.5. In the red ginseng concentrate of Preparation Example 2, purified water was added to adjust the sugar content to 45 Brix, and a coating solution was prepared by stirring with a stirrer at a speed of 55±5 RPM and a temperature of 40±5°C. When the coating solution was prepared, the capsule was put into a fluidized bed device (EG1 Lab-1, EG1 Co., Ltd) as a seed, and then the temperature of the coating machine was adjusted to 40°C or less. The coating solution was sprayed at an amount of 2 ml/min. After spraying was completed, it was dried at 40° C. or less for 20 minutes or more.
5-2. 소형 연질 캡슐 2차 코팅5-2. Small soft capsule secondary coating
2차 코팅은 코팅물로 사용하고 유동층 코팅 방법으로 수행하였다. 코팅물로는 제조예 1에서 제조한 홍삼 분말을 사용하였고, 씨드로는 제조예 5에서 제조한 1차 코팅된 소형 연질 캡슐을 사용하였다. 1차 코팅된 소형 연질 캡슐과 홍삼 분말의 중량 대비 비율은 95:5로 하였다. 홍삼 분말과 정제수 중량을 2:8의 비율로 녹여서 상부 구동 방식 혼합기로 균질화한 뒤 미량 연속 펌프를 이용하여 유동층 코팅기 내부로 노즐 분사하였다.The secondary coating was used as a coating and was performed by a fluidized bed coating method. Red ginseng powder prepared in Preparation Example 1 was used as a coating material, and a first coated small soft capsule prepared in Preparation Example 5 was used as a seed. The weight ratio of the first coated small soft capsule and red ginseng powder was 95:5. After dissolving the weight of red ginseng powder and purified water in a ratio of 2:8, homogenized with an upper drive type mixer, nozzle sprayed into the fluidized bed coater using a micro-continuous pump.
1차 코팅된 소형 연질 캡슐을 유동층 기기에 시드로 투입 후 코팅기 온도를 40℃ 이하로 조절하였다. 코팅액을 5ml/분 양으로 분사하였다. 분사 완료한 후 40℃ 이하에서 20분 이상 건조하였다. After the first coated small soft capsule was added to the fluidized bed device as a seed, the temperature of the coating machine was adjusted to 40°C or less. The coating solution was sprayed at an amount of 5 ml/min. After spraying was completed, it was dried at 40° C. or less for 20 minutes or more.
1차, 2차 코팅하여 제조된 다중 코팅된 소형 연질 캡슐은 갈색의 환 제형으로 홈, 주름, 무늬, 갈라짐이 없었고, 고유의 색택과 향미를 가지며, 이미, 이취가 없었다. 또한 다중 코팅된 소형 연질 캡슐의 경도는 2KP 이상이었고, 대장균군은 음성으로 확인되었다. 육안으로 확인된 다중 코팅된 소형 연질 캡슐을 스틱 포장하여 밀봉하였다. 각 스틱의 중량 편차(%)를 확인하였다. 중량편차가 5~10%인 것이 2개 이하였다.The multi-coated small soft capsules prepared by the first and second coatings are brown pill formulations, have no grooves, wrinkles, patterns, and cracks, have a unique color and flavor, and have no odor. In addition, the hardness of the multi-coated small soft capsule was 2KP or more, and the coliform group was confirmed as negative. The multi-coated small soft capsules confirmed by the naked eye were sealed by stick packaging. The weight deviation (%) of each stick was checked. Two or less had a weight deviation of 5-10%.
실험예 1. 다중 코팅된 소형 연질 캡슐의 물성 평가Experimental Example 1. Evaluation of physical properties of multi-coated small soft capsules
1-1. 다중 코팅된 소형 연질 캡슐 내 액상 원료의 형태 유지 여부 확인1-1. Check whether the shape of the liquid raw material is maintained in the multi-coated small soft capsule
소형 연질 캡슐은 하드 캡슐에 비해서 외막이 외부 충격에 의해서 쉽게 파괴될 수 있어 대기 중에 노출시 보관이나, 유통에 어려움이 있었다. 따라서, 소형 연질 캡슐 내에 포함된 오일류, 착향료와 같은 액상 원료의 형태를 유지하면서도, 외부 충격을 상쇄할 수 있는 코팅이 필요하였다. 따라서, 본 발명에서는 1차, 2차 코팅하여 소형 연질 캡슐 내부의 원료의 형태를 유지할 수 있는지 확인하였다. 1차 코팅, 2차 코팅된 캡슐의 내구성은 경도를 측정하여 확인하였다. 경도는 경도측정기(TBH425, ERWEKA GmbH)로 측정하였다. 1차 코팅된 캡슐의 경도 측정 결과를 표 4에 나타내고, 2차 코팅된 캡슐(다중 코팅된 캡슐)의 경도 측정 결과를 표 5에 나타낸다.Compared to hard capsules, small soft capsules have difficulty in storage or distribution when exposed to air because the outer membrane can be easily destroyed by external impact. Accordingly, there is a need for a coating capable of offsetting external impact while maintaining the shape of liquid raw materials such as oils and flavorings contained in a small soft capsule. Therefore, in the present invention, it was confirmed whether the shape of the raw material inside the small soft capsule can be maintained by the first and second coating. The durability of the first and second coated capsules was confirmed by measuring the hardness. The hardness was measured with a hardness tester (TBH425, ERWEKA GmbH). Table 4 shows the hardness measurement results of the primary coated capsule, and Table 5 shows the hardness measurement results of the secondary coated capsule (multi-coated capsule).
1차 코팅된 캡슐은 해당 직경에서 사람이 저작할 수 있는 일반적인 경도인 1KP 내지 5KP의 이내 결과값인 2.4KP로 확인되었고, 다중 코팅된 캡슐은 코팅하지 않은 소형 연질 캡슐 또는 1차 코팅된 캡슐에 비해서, 경도가 높아져 외부 충격에도 깨지는 캡슐의 비율이 낮았고, 이에 따라 오일류, 착향료와 같은 액상 원료의 형태가 유지되었다.The primary coated capsule was confirmed to be 2.4 KP, which is a result within the range of 1 KP to 5 KP, which is a general hardness that can be masticated by humans at the corresponding diameter, and the multi-coated capsule is applied to an uncoated small soft capsule or a primary coated capsule. In contrast, the hardness of the capsules was increased and the proportion of the capsules that were broken even by external impact was low, and accordingly, the shape of liquid raw materials such as oils and flavoring agents was maintained.
1-2. 다중 코팅된 소형 연질 캡슐간 접착 정도 평가1-2. Evaluation of adhesion between multi-coated small soft capsules
1차, 2차 코팅시에는 유동층 코팅 방법을 이용하였다. 일반적으로 유동층 과립품은 강제 열풍 건조한 상태로 대기 노출시 수분이 쉽게 흡착되며 과립간에 점성이 생기고 붙어 덩어리가 형성되어 품질이 급감하는 현상이 있다. In the first and second coating, a fluidized bed coating method was used. In general, fluidized bed granules are easily adsorbed by moisture when exposed to the atmosphere under forced hot air drying, and there is a phenomenon in which the quality of the granules is drastically reduced due to the formation of a stick and sticking between the granules.
대조군은 제조예 5에서 홍삼 농축액으로 1차 코팅한 소형 연질 캡슐을 사용하고, 시험군은 제조예 5에서 홍삼 농축액으로 1차 코팅하고, 홍삼 분말로 2차 코팅한 소형 연질 캡슐을 사용하였다. 대조군와 시험군을 3시간 동안 일반 실내 조건인 25℃, 50~60% RH에 노출시키고, 노출 시간별로 코팅된 캡슐간 접착하여 덩어리지는 정도를 10메쉬 체에 통과시켜 통과 비율로 평가하였다. 캡슐이 덩어리질 경우 체를 통과하지 못하여 통과 비율이 낮아지게 된다. 대조군와 시험군의 10메쉬 통과 비율(%)를 하기 표 6에 나타낸다.The control group used a small soft capsule first coated with red ginseng concentrate in Preparation Example 5, and the test group used a small soft capsule coated with red ginseng concentrate first and second coated with red ginseng powder in Preparation Example 5. The control group and the test group were exposed to 25° C., 50-60% RH, which is a general indoor condition for 3 hours, and the degree of adhesion between the coated capsules and lumping by exposure time was passed through a 10-mesh sieve and evaluated as a pass rate. If the capsule is lumpy, it cannot pass through the sieve and the passage rate is lowered. The 10 mesh passing ratio (%) of the control group and the test group is shown in Table 6 below.
표 6에 나타낸 바와 같이, 시험군의 경우 캡슐간 접착이 적고 3시간 후에도 10메쉬 체를 통과하는 캡슐이 100%였다(도 2 및 도 3 참조). 반면에, 대조군의 경우 시간에 비례하여 코팅된 캡슐간 접착 정도가 심해져서 3시간째에는 10메쉬 체를 통과하는 캡슐이 없었다. As shown in Table 6, in the case of the test group, the adhesion between the capsules was small and the capsules passing through the 10-mesh sieve after 3 hours were 100% (see FIGS. 2 and 3). On the other hand, in the case of the control group, the degree of adhesion between the coated capsules was increased in proportion to time, so there was no capsule passing through the 10-mesh sieve at 3 hours.
위 결과를 통해서 1차 코팅된 캡슐에 홍삼 분말 코팅시 비코팅 캡슐보다 대기 중 수분 흡착을 효과적으로 억제하여 캡슐 고유의 형태를 유지시켜 품질이 우수해지는 것을 알 수 있었다. Through the above results, it was found that when the red ginseng powder was coated on the first coated capsule, moisture absorption in the air was effectively suppressed than the non-coated capsule, and the original shape of the capsule was maintained, thereby improving the quality.
Claims (15)
상기 액상 원료는 오일인 다중 코팅된 연질 캡슐.The method according to claim 1,
The liquid raw material is an oil multi-coated soft capsule.
상기 액상 원료에 착향료 및 지용성 비타민 중 적어도 하나를 추가로 포함하는 다중 코팅된 연질 캡슐.The method according to claim 2,
Multi-coated soft capsules further comprising at least one of a flavoring agent and a fat-soluble vitamin in the liquid raw material.
상기 연질 캡슐의 직경은 1 mm 내지 10 mm인 다중 코팅된 연질 캡슐.The method according to claim 1,
The diameter of the soft capsule is 1 mm to 10 mm multi-coated soft capsule.
상기 연질 캡슐의 피막은 글리세린, 한천, 펙틴, 스테비올 배당체 및 알긴산나트륨을 포함하는 피막제가 경화된 것인 다중 코팅된 연질 캡슐.The method according to claim 1,
The coating of the soft capsule is a multi-coated soft capsule that is cured with a coating agent containing glycerin, agar, pectin, steviol glycoside and sodium alginate.
상기 피막제의 점도는 300cps 내지 850cps인 다중 코팅된 연질 캡슐.The method of claim 5,
The viscosity of the coating agent is 300cps to 850cps multi-coated soft capsule.
상기 홍삼 추출물은 20 Brix 내지 70 Brix인 다중 코팅된 연질 캡슐.The method according to claim 1,
The red ginseng extract is a multi-coated soft capsule of 20 Brix to 70 Brix.
상기 홍삼 추출물의 진세노사이드 Rg1, Rb1, Rg3의 합은 1 mg/g 내지 15 mg/g인 다중 코팅된 연질 캡슐.The method according to claim 1,
The sum of ginsenosides Rg1, Rb1, and Rg3 of the red ginseng extract is 1 mg/g to 15 mg/g of multi-coated soft capsules.
상기 홍삼 분말의 입도는 120 메쉬를 통과하는 분말이 60% 이상인 다중 코팅된 연질 캡슐.The method according to claim 1,
The particle size of the red ginseng powder is a multi-coated soft capsule having a powder passing through 120 mesh of 60% or more.
상기 코팅은 유동층 기기를 이용하여 수행되는 다중 코팅된 연질 캡슐. The method according to claim 1,
The coating is a multi-coated soft capsule performed using a fluid bed device.
상기 연질 캡슐 50중량부에 대해서, 홍삼 추출물은 20 중량부 내지 60 중량부, 홍삼 분말 1 내지 20중량부로 포함되는 다중 코팅된 연질 캡슐.The method according to claim 1,
With respect to 50 parts by weight of the soft capsule, the red ginseng extract is a multi-coated soft capsule containing 20 parts by weight to 60 parts by weight, and 1 to 20 parts by weight of red ginseng powder.
1차 코팅물에 식물 추출물이 추가로 코팅된 다중 코팅된 연질 캡슐.The method according to claim 1,
Multi-coated soft capsules coated with plant extracts in the primary coating.
연질 캡슐 50중량부에 대해서, 식물 추출물 1 내지 20중량부로 포함되는 다중 코팅된 연질 캡슐.The method of claim 12,
With respect to 50 parts by weight of soft capsules, multi-coated soft capsules containing 1 to 20 parts by weight of plant extract.
상기 식물 추출물은 감초, 당귀, 황기, 백작약, 백출, 숙지황, 천궁, 진피, 갈근, 맥문동, 두충, 산약, 우슬, 결명자, 원지, 생강, 대추, 구기자, 복분자, 천마, 오미자, 산수유 및 이의 조합으로 이루어진 군으로부터 선택되는 하나의 원료로부터 추출된 것인 다중 코팅된 연질 캡슐. The method of claim 12,
The plant extracts are Licorice, Angelica, Astragalus, Baekchul, Sukjihwang, Cheongung, Dermis, Galgeun, Maekmundong, Duchung, Sanyak, Useul, Cassia tora, Wonji, Ginger, Jujube, Gugija, Bokbunja, Cheonma, Schisandra, Cornus and a combination thereof Multi-coated soft capsules that are extracted from one raw material selected from the group consisting of.
상기 다중 코팅된 연질 캡슐의 경도는 0.5KP 내지 5KP인 다중 코팅된 연질 캡슐.
The method according to claim 1,
The hardness of the multi-coated soft capsule is 0.5KP to 5KP multi-coated soft capsule.
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| EP0116311A1 (en) * | 1983-01-17 | 1984-08-22 | Morishita Jintan Co., Ltd. | Double soft capsules and production thereof |
| JPH07196478A (en) * | 1993-12-30 | 1995-08-01 | Hajime Sugii | Soft capsule for highly safe food and medicine |
| KR20030066136A (en) * | 2002-02-04 | 2003-08-09 | (주)케비젠 | Preparation of round microcapsules comprising powders of a steamed red-ginseng or a ginseng |
| KR20140080844A (en) * | 2012-12-20 | 2014-07-01 | 주식회사 아리바이오 | Transparent Soft Capsules Containing Granules or Pellets, Methods of Preparing Thereof and Apparatus for Preparing Thereof |
| KR20160116827A (en) | 2015-03-31 | 2016-10-10 | 주식회사 케이티앤지 | Nozzle and apparatus to manufacture flavor capsule of cigarette having the same |
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| KR101269911B1 (en) * | 2010-12-06 | 2013-05-31 | 주식회사 한국인삼공사 | Soft Capsule Comprising Red Ginseng Oil As Diluent Oil |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0116311A1 (en) * | 1983-01-17 | 1984-08-22 | Morishita Jintan Co., Ltd. | Double soft capsules and production thereof |
| JPH07196478A (en) * | 1993-12-30 | 1995-08-01 | Hajime Sugii | Soft capsule for highly safe food and medicine |
| KR20030066136A (en) * | 2002-02-04 | 2003-08-09 | (주)케비젠 | Preparation of round microcapsules comprising powders of a steamed red-ginseng or a ginseng |
| KR20140080844A (en) * | 2012-12-20 | 2014-07-01 | 주식회사 아리바이오 | Transparent Soft Capsules Containing Granules or Pellets, Methods of Preparing Thereof and Apparatus for Preparing Thereof |
| KR20160116827A (en) | 2015-03-31 | 2016-10-10 | 주식회사 케이티앤지 | Nozzle and apparatus to manufacture flavor capsule of cigarette having the same |
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