KR20200014320A

KR20200014320A - Apcs의 발현을 억제하는 핵산

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Publication number: KR20200014320A
Application number: KR1020197036566A
Authority: KR
Inventors: 히로유키 아리야마; 다쿠야 무라카미; 다카시 이마에다; 다츠야 미야자와
Original assignee: 쿄와 기린 가부시키가이샤
Priority date: 2017-05-31
Filing date: 2018-05-31
Publication date: 2020-02-10
Also published as: EP3633037A1; TW201903149A; EP3633037A4; AU2018277476A1; CN110832078A; CA3065149A1; WO2018221649A1; US20200190514A1; US11466272B2; JPWO2018221649A1

Abstract

본 발명은, 센스쇄 핵산 및 안티센스쇄 핵산으로 이루어지고, 적어도 11개의 염기쌍의 이중쇄 영역을 포함하는 이중쇄 핵산이며, 상기 안티센스쇄 핵산 중의, 적어도 17개의 뉴클레오티드이며 많아도 30개의 뉴클레오티드의 쇄길이의 올리고 뉴클레오티드쇄에 있어서, 서열 번호 1288∼1930 중 어느 것으로 표시되는 염기 서열을 포함하는 표적 APCS mRNA 서열과 상보적인 APCS 유전자의 발현을 억제시키는 이중쇄 핵산을 제공한다.

Description

APCS의 발현을 억제하는 핵산

본 발명은, APCS의 발현을 억제하는 핵산 또는 상기 핵산을 포함하는 의약 조성물에 관한 것이다.

APCS(amyloid P component, serum)(별명 Serum amyloid P, SAP 혹은 펜트락신-2(Pentraxin-2)라고도 함)은 223 아미노산으로 구성되는 당단백질의 오량체 구조를 갖는다. APCS는 간에서 생성되는 단백질이며, 혈액 중에 30∼50 μg/mL라는 비교적 고농도로 존재한다.

또한, APCS는 칼슘 의존적으로 모든 종류의 아밀로이드 섬유에 결합하는 생화학적 특성을 가지며, 아밀로이드를 갖는 환자의 아밀로이드 중에도 20,000 mg이나 되는 다량의 APCS가 포함되어 있는 것이 알려져 있다(비특허문헌 1).

APCS는 모든 아밀로이드 관련 질환 환자의 아밀로이드 중에 존재하기 때문에, 아밀로이드 관련 질환 환자의 진단 마커로서 이용되고 있다(비특허문헌 2).

아밀로이드 관련 질환은, 아밀로이드 섬유로서 알려져 있는 비정상 불용성 단백질 섬유가 조직에 침착하여 장기 장해가 야기되는 질환이다.

프로테아제에 의한 분해나 면역 세포에 의한 탐식에 대한 APCS의 내성에 의해, APCS가 결합한 아밀로이드를 안정화할 수 있는 것이 분명해졌고, 또한, APCS의 아밀로이드에 대한 결합을 저해함으로써 장기에 아밀로이드가 침착하는 것 및 그것에 수반되는 조직 장해를 경감할 수 있는 것이 동물 모델을 이용한 연구 및 임상 연구에서 강하게 시사되어 있다(비특허문헌 3, 4). APCS의 발현을 특이적으로 억제하는 것에 의해, 아밀로이드 관련 질환을 예방 또는 치료할 수 있다고 기대할 수 있지만, APCS의 발현을 특이적으로 억제하는 의약품은 지금까지 보고되지 않았다.

유전자의 발현 자체를 억제하는 방법으로는, 예컨대 RNA 간섭(RNA interference, RNAi라고도 함)을 이용한 방법 등이 알려져 있다. 구체적으로는, 표적으로 하는 유전자와 동일한 서열을 갖는 이중쇄 RNA를 도입하는 것에 의해, 상기 표적 유전자의 발현이 특이적으로 억제되는 것이 발견되어, 짧은 간섭 RNA(short interfering RNA; siRNA)로 이름 붙여졌다(특허문헌 1). 또한, RNA 간섭 이외의 유전자의 발현을 억제하는 방법으로서 안티센스법이 알려져 있다(특허문헌 2).

인간의 APCS mRNA를 표적으로 하는 siRNA 서열의 일부는 개시되어 있지만, 상기 siRNA 서열이 인간의 APCS의 발현을 억제하는 것은 알려져 있지 않다(특허문헌 3, 4).

특허문헌 1 : 국제 공개 제2001/75164호 특허문헌 2 : 국제 공개 제98/56905호 특허문헌 3 : 국제 공개 제2005/116204호 특허문헌 4 : 국제 공개 제2008/043561호

비특허문헌 1 : 아밀로이드, 4 : 4, 274-295(1997) 비특허문헌 2 : N Engl J Med. 1990 ; 323 : 508-13 비특허문헌 3 : Nature 468 : 93-97.(2010) 비특허문헌 4 : N. Engl. J. Med. 373 : 1106-14.(2015)

본 발명은, APCS의 발현을 억제하는 것이 가능한 핵산을 제공하는 것을 목적으로 한다.

본 발명은, 이하의 (1)∼(13)에 관한 것이다.

(1) 센스쇄 핵산 및 안티센스쇄 핵산으로 이루어지고, 적어도 11개의 염기쌍의 이중쇄 영역을 포함하는 이중쇄 핵산으로서, 상기 안티센스쇄 핵산 중의, 적어도 17개의 뉴클레오티드이며 많아도 30개의 뉴클레오티드의 쇄길이의 올리고뉴클레오티드쇄에 있어서, 서열 번호 1288∼1930 중 어느 것으로 표시되는 염기 서열을 포함하는 표적 APCS mRNA 서열과 상보적인 APCS 유전자의 발현을 억제하는 이중쇄 핵산.

(2) 상기 이중쇄 영역이 11∼27개의 염기쌍이며, 상기 안티센스쇄 핵산의 5' 말단으로부터 2번째의 뉴클레오티드가, 상기 표적 APCS mRNA 서열의 3' 말단으로부터 2번째의 뉴클레오티드와 상보하는 (1)에 기재된 이중쇄 핵산.

(3) 상기 센스쇄 핵산의 3' 말단 및 상기 안티센스쇄 핵산의 5' 말단, 및/또는, 상기 센스쇄 핵산의 5' 말단 및 상기 안티센스쇄 핵산의 3' 말단이, 평활 말단을 형성하는 (1) 또는 (2)에 기재된 이중쇄 핵산.

(4) 상기 센스쇄 핵산은, 21개의 뉴클레오티드의 쇄길이를 가지며, 또한 상기 안티센스쇄 핵산은, 21개의 뉴클레오티드의 쇄길이를 갖는 (1)∼(3)의 어느 하나에 기재된 이중쇄 핵산.

(5) 19개의 염기쌍의 이중쇄 영역을 포함하고, 상기 이중쇄 영역 내의 40∼65%의 뉴클레오티드가 2'-O-메틸 수식 뉴클레오티드인 (4)에 기재된 이중쇄 핵산.

(6) 상기 안티센스쇄 핵산은, 서열 번호 645∼1287 및 1975∼2018 중 어느 것으로 표시되는 염기 서열을 포함하는 (1)∼(5)의 어느 하나에 기재된 이중쇄 핵산.

(7) 상기 센스쇄 핵산은, 서열 번호 2∼644 및 1931∼1974 중 어느 것으로 표시되는 염기 서열을 포함하는 (1)∼(6)의 어느 하나에 기재된 이중쇄 핵산.

(8) 상기 센스쇄 핵산은, 서열 번호 2∼644 및 1931∼1974 중 어느 것으로 표시되는 염기 서열을 포함하고, 그것에 대응하여, 상기 안티센스쇄 핵산은, 서열 번호 645∼1287 및 1975∼2018 중 어느 것으로 표시되는 염기 서열을 포함하는 (1)∼(7)의 어느 하나에 기재된 이중쇄 핵산.

(9) 리간드를 포함하는 (1)∼(8)의 어느 하나에 기재된 이중쇄 핵산.

(10) (1)∼(9)의 어느 하나에 기재된 이중쇄 핵산의 안티센스쇄 핵산만으로 이루어진 단일쇄 핵산.

(11) (1)∼(10)의 어느 하나에 기재된 핵산을 포함하는 의약 조성물.

(12) APCS를 포함한 아밀로이드 섬유에 의해 매개되는 장해를 치료하는 방법으로서, 치료상 유효량의 (1)∼(10)의 어느 하나에 기재된 핵산 또는 (11)에 기재된 의약 조성물을, 그와 같은 치료를 필요로 하는 인간에게 투여하는 단계를 포함하는 방법.

(13) 상기 장해가 아밀로이드 관련 질환인 (12)에 기재된 방법.

본 발명에 의하면, APCS의 발현을 억제하는 것이 가능한 핵산을 제공할 수 있다.

본 발명에 있어서, 핵산의 표적으로 하는 APCS mRNA는, Genbank 수탁 번호 NM_001639.3으로서 등록되어 있는 서열 번호 1에 상동이며, 서열 번호 1에서의 T가 U로 갱신된 염기 서열을 갖는 APCS의 완전 길이 mRNA이다. mRNA의 상보 DNA를 1st 스트랜드 cDNA, 그것으로부터 이중쇄로 할 때에 합성되는 DNA를 2nd 스트랜드 cDNA로 정의하는 경우에, 서열 번호 1은, APCS 2nd 스트랜드 cDNA의 염기 서열을 나타낸다. 여기서, APCS mRNA의 염기 서열과, APCS 2nd 스트랜드 cDNA의 염기 서열은, 상동인 관계에 있다.

1. 본 발명의 핵산

본 발명에 있어서, APCS mRNA 서열에 대하여 상보적인 염기 서열을 포함하는 핵산을 안티센스쇄 핵산으로 칭하고, 안티센스쇄 핵산의 염기 서열에 대하여 상보적인 염기 서열을 포함하는 핵산을 센스쇄 핵산으로 칭한다. 본 명세서에서 「본 발명의 핵산」이라고 하는 경우, 특별히 언급하지 않는 한, 안티센스쇄 핵산 또는 센스쇄 핵산의 단일쇄 핵산, 및 안티센스쇄 핵산 및 센스쇄 핵산이 쌍을 형성한 이중쇄 핵산을 포함하는 의미로 이용된다.

본 발명의 핵산으로는, 뉴클레오티드 또는 상기 뉴클레오티드와 동등한 기능을 갖는 분자가 중합한 분자라면 어떠한 분자이어도 좋으며, 예컨대 리보뉴클레오티드의 중합체인 RNA, 데옥시리보뉴클레오티드의 중합체인 DNA, 리보뉴클레오티드와 데옥시리보뉴클레오티드의 중합체인 키메라 핵산, 및 이들의 핵산(RNA, DNA 및 키메라 핵산)의 적어도 하나의 뉴클레오티드가 상기 뉴클레오티드와 동등한 기능을 갖는 분자로 치환된 뉴클레오티드 중합체를 들 수 있다. RNA 중의 우라실(U)은, DNA에서는 티민(T)으로 일의적으로 갱신된다.

뉴클레오티드와 동등한 기능을 갖는 분자로는, 예컨대 뉴클레오티드에 수식을 실시한 뉴클레오티드 유도체 등을 들 수 있다.

뉴클레오티드 유도체를 이용함으로써, 특별히 한정되는 것이 아니지만, 예컨대 RNA 혹은 DNA와 비교하여, 뉴클레아제 내성을 향상 혹은 안정화시킬 수 있고, 상보쇄 핵산과의 어피니티를 향상시킬 수 있고, 세포 투과성을 향상시킬 수 있고, 및/또는 가시화할 수 있는 등의 이점이 있다.

뉴클레오티드 유도체로는, 예컨대 당부 수식 뉴클레오티드, 인산디에스테르 결합 수식 뉴클레오티드, 염기 수식 뉴클레오티드, 및 당부, 인산디에스테르 결합, 및 염기의 2개 이상이 동시에 수식된 뉴클레오티드 등을 들 수 있다.

당부 수식 뉴클레오티드로는, 뉴클레오티드의 당의 화학 구조의 일부 또는 전부에 대하여, 임의의 치환기로 수식 혹은 치환한 것 또는 임의의 원자로 치환한 것이라면 어떠한 것이어도 좋지만, 2'-수식 뉴클레오티드가 바람직하게 이용된다.

2'-수식 뉴클레오티드로는, 예컨대 리보스의 2'-OH기가 OR, R, R'OR, SH, SR, NH₂, NHR, NR₂, N₃, CN, F, Cl, Br 및 I로 이루어진 군(R은 알킬 또는 아릴이고, 바람직하게는 탄소수 1∼6의 알킬이고, R'는 알킬렌이고, 바람직하게는 탄소수 1∼6의 알킬렌이고, NR₂의 2개의 R은 동일해도 좋고 상이해도 좋다)에서 선택되는 치환기로 치환된 2'-수식 뉴클레오티드를 들 수 있다.

2'-수식 뉴클레오티드로는, 리보스의 2'-OH기가 F 또는 메톡시기로 치환된 2'-수식 뉴클레오티드(각각, 2'-F 수식 뉴클레오티드 또는 2'-O-메틸 수식 뉴클레오티드라고도 함)가 바람직하게 이용된다.

2'-수식 뉴클레오티드로는, 리보스의 2'-OH기가 2-(메톡시)에톡시기, 3-아미노프로폭시기, 2-[(N,N-디메틸아미노)옥시]에톡시기, 3-(N,N-디메틸아미노)프로폭시기, 2-[2-(N,N-디메틸아미노)에톡시]에톡시기, 2-(메틸아미노)-2-옥소에톡시기, 2-(N-메틸카바모일)에톡시기 및 2-시아노에톡시기로 이루어진 군에서 선택되는 치환기로 치환된 2'-수식 뉴클레오티드 등도 들 수 있다.

당부 수식 뉴클레오티드로는, 당부에 가교 구조를 도입하는 것에 의해 2개의 고리형 구조를 갖는 가교 구조형 인공 핵산(Bridged Nucleic Acid)(BNA)을 들 수 있고, 구체적으로는, 2' 위의 산소 원자와 4' 위의 탄소 원자가 메틸렌을 통해 가교한 록트 인공 핵산(Locked Nucleic Acid)(LNA)[Tetrahedron Letters, 38, 8735, (1997) 및 Tetrahedron, 54, 3607, (1998)], 에틸렌 가교 구조형 인공 핵산(Ethylene bridged nucleic acid)(ENA)[Nucleic Acid Research, 32, e175(2004)], 구속형 에틸(Constrained Ethyl)(cEt)[The Journal of Organic Chemistry 75, 1569 (2010)], 아미도 가교구조형 핵산(Amido-Bridged Nucleic Acid)(AmNA)[Chem Bio Chem 13, 2513(2012)], 및 2'-0,4'-c-스피로시클로프로필렌 가교구조형 핵산(2'-0,4'-c-Spirocyclopropylene bridged nucleic acid)(scpBNA)[Chem. Commun., 51, 9737(2015)] 등을 들 수 있다.

당부 수식 뉴클레오티드로는, 펩티드 핵산(PNA)[Acc. Chem. Res., 32, 624(1999)], 옥시펩티드핵산(OPNA)[J. Am. Chem. Soc., 123, 4653 (2001)], 및 펩티드 리보핵산(PRNA)[J. Am. Chem. Soc., 122, 6900(2000)] 등도 들 수 있다.

인산디에스테르 결합 수식 뉴클레오티드로는, 뉴클레오티드의 인산디에스테르 결합의 화학 구조의 일부 또는 전부에 대하여, 임의의 치환기로 수식 혹은 치환한 것 또는 임의의 원자로 치환한 것이라면 어떠한 것이어도 좋다.

인산디에스테르 결합 수식 뉴클레오티드로는, 예컨대 인산디에스테르 결합이 포스포로티오에이트 결합에 치환된 뉴클레오티드, 인산디에스테르 결합이 포스포로디티오에이트 결합에 치환된 뉴클레오티드, 인산디에스테르 결합이 알킬포스포네이트 결합에 치환된 뉴클레오티드, 및 인산디에스테르 결합이 포스포로아미데이트 결합에 치환된 뉴클레오티드 등을 들 수 있다.

염기 수식 뉴클레오티드로는, 뉴클레오티드의 염기의 화학 구조의 일부 또는 전부에 대하여, 임의의 치환기로 수식 혹은 치환한 것 또는 임의의 원자로 치환한 것이라면 어떠한 것이어도 좋다.

염기 수식 뉴클레오티드로는, 예컨대 염기 내의 산소 원자가 황원자로 치환된 뉴클레오티드, 염기 내의 수소 원자가 탄소수 1∼6의 알킬기, 할로겐 등으로 치환된 것, 메틸기가 수소, 히드록시메틸, 탄소수 2∼6의 알킬기 등으로 치환된 것, 아미노기가 탄소수 1∼6의 알킬기, 탄소수 1∼6의 알카노일기, 옥소기, 히드록시기 등으로 치환된 것을 들 수 있다. 또, 사이토신(C) 대신에 5-메틸사이토신(5-mC)을 염기 수식 뉴클레오티드로서 이용하는 것도, 본 발명의 바람직한 형태의 하나이다.

또 다른 뉴클레오티드 유도체로는, 뉴클레오티드 또는 상기 뉴클레오티드 유도체에, 리간드, 콜레스테롤, 지방산, 토코페롤, 레티노이드 등의 지질류, N-아세틸갈락토사민(GalNAc), 갈락토스(Gal), 만노스(Man) 등의 당류, 완전 항체, Fab, scFv, VHH 등의 프래그먼트 항체, 저밀도 리포단백질(LDL), 인간 혈청 알부민 등의 단백질, RGD, NGR, R9, CPP 등의 펩티드류, 페나진, 페난트리딘, 안트라퀴논, 엽산 등의 저분자, 합성 폴리아미노산 등의 합성 폴리머, 핵산 압타머, 아크리딘, 플루오레세인, 로다민, 쿠마린 등의 색소, Cy3 시리즈, Alexa 시리즈(등록상표), 블랙홀 켄처 등의 형광단 등의 별도의 화학 물질을, 직접 또는 링커를 통해 부가한 것도 들 수 있다. 구체적으로는 폴리아민 부가 뉴클레오티드 유도체, 콜레스테롤 부가 뉴클레오티드 유도체, 스테로이드 부가 뉴클레오티드 유도체, GalNAc 부가 뉴클레오티드 유도체, 담즙산 부가 뉴클레오티드 유도체, 지방산 부가 뉴클레오티드 유도체, 비타민 부가 뉴클레오티드 유도체, Cy5 부가 뉴클레오티드 유도체, Cy3 부가 뉴클레오티드 유도체, 6-FAM 부가 뉴클레오티드 유도체 및 비오틴 부가 뉴클레오티드 유도체 등을 들 수 있고, 바람직하게는 GalNAc 부가 뉴클레오티드 유도체를 들 수 있다. 이들은, 고상 상에서의 신장 반응시에, 고상 상에서 반응 가능한 수식제를 반응시킴으로써 5' 말단 및/혹은 3' 말단, 및/또는 서열 내부에 수식을 실시할 수 있다. 또한, 아미노기, 머캅토기, 아지드기 또는 3중 결합 등의 작용기를 도입한 핵산을 미리 합성 및 정제해 두고, 이들에 수식제를 작용시킴으로써 얻을 수도 있다.

뉴클레오티드 유도체는, 핵산 내의 다른 뉴클레오티드 또는 뉴클레오티드 유도체와 알킬렌 구조, 펩티드 구조, 뉴클레오티드 구조, 에테르 구조 및 에스테르 구조, 및 이들의 적어도 2개를 조합한 구조 등의 가교 구조를 형성해도 좋다.

본 발명의 핵산은, 핵산의 분자 중의 일부 또는 전부의 원자가 질량수가 상이한 원자(동위체)로 치환된 것도 포함한다.

본 명세서에서 「상보」란, 2개의 염기 사이에서 염기쌍합을 할 수 있는 관계를 의미하며, 예컨대, 아데닌과 티민 또는 우라실의 관계, 및 구아닌과 사이토신의 관계와 같이 느슨한 수소 결합을 통해, 이중쇄 영역 전체적으로 이중 나선 구조를 취하는 것을 말한다. 아데닌과 티민 또는 우라실의 관계, 및 구아닌과 사이토신의 관계에 있어서, A, T(U), G, C의 각 염기는, 한쪽 혹은 쌍방이 수식된 염기인 경우에도, 2개의 염기 사이에서 느슨한 수소 결합을 통해 염기쌍합을 할 수 있는 경우에는, 이들 염기끼리의 관계도 상보라고 할 수 있다.

본 명세서에서 「상보적」이란, 2개의 뉴클레오티드 서열이 완전히 상보하는 경우뿐만 아니라, 상기 2개의 뉴클레오티드 서열 사이에서 0∼30%, 바람직하게는 0∼20%, 보다 바람직하게는 0∼10%의 미스매치 염기를 가질 수 있고, 예컨대, APCS mRNA 서열에 대하여 상보적인 안티센스쇄 핵산은, 상기 mRNA의 부분 염기 서열과 완전히 상보하는 염기 서열을 포함하거나, 완전히 상보하는 염기 서열에 있어서 하나 또는 복수의 염기의 치환을 포함해도 좋은 염기 서열을 포함하는 것을 의미한다. 안티센스쇄 핵산은, 표적 유전자의 표적 서열에 대하여 1∼8개, 바람직하게는 1∼6개, 보다 바람직하게는 1∼4개, 더욱 바람직하게는 1∼3개, 특히 바람직하게는 1∼2개, 특히 더 바람직하게는 1개의 미스매치 염기를 갖고 있어도 좋다.

구체적으로는, 안티센스쇄 핵산이 21개의 뉴클레오티드의 쇄길이(21 염기 길이)인 경우에는, 표적 유전자의 표적 뉴클레오티드 서열에 대하여 1∼6개, 바람직하게는 1∼5개, 보다 바람직하게는 1∼4개, 더욱 바람직하게는 1∼3개, 특히 바람직하게는 1∼2개, 특히 더 바람직하게는 1개의 미스매치 염기를 가져도 좋으며, 그 미스매치의 위치는, 각각의 안티센스쇄에서의 뉴클레오티드 서열의 5' 말단 또는 3' 말단이어도 좋다.

본 명세서에서 「상보적」이란, 한쪽의 뉴클레오티드 서열이 다른쪽 뉴클레오티드 서열과 완전히 상보하는 염기 서열에 있어서, 하나 혹은 복수의 염기가 부가 및/또는 결실된 서열인 경우를 포함한다. 예컨대, 본 발명에서의 안티센스쇄 핵산은, APCS mRNA 서열에 대하여 완전히 상보하는 염기 서열에서의 염기의 부가에 의해, 표적 APCS mRNA 서열에 1개 또는 2개의 벌지 염기를 가져도 좋다.

본 발명에서는, 안티센스쇄 핵산 혹은 센스쇄 핵산에 있어서, 1개 또는 2개의 벌지 염기를 가져도 좋다.

본 발명에 있어서, 「벌지 염기」란, 다른쪽 뉴클레오티드 서열과 상보적인 염기쌍을 형성하지 않는 염기를 가리킨다.

본 발명의 안티센스쇄 핵산으로는, 표적 APCS mRNA 서열에 대하여 완전히 상보적인 염기 서열을 포함하는 핵산이 이용되지만, 상기 핵산 중 1∼3 염기, 바람직하게는 1∼2 염기, 보다 바람직하게는 1 염기가 결실, 치환 또는 부가된 것을 이용해도 좋다.

APCS의 발현을 억제하는 핵산으로는, 표적 APCS mRNA 서열에 대하여 상보적인 염기 서열을 포함하는 핵산(안티센스쇄 핵산)인 단일쇄 핵산 또는 표적 APCS mRNA 서열에 대하여 상보적인 염기 서열을 포함하는 핵산(안티센스쇄 핵산)과, 상기 핵산의 염기 서열에 대하여 상보적인 염기 서열을 포함하는 핵산(센스쇄 핵산)으로 이루어진 이중쇄 핵산이 적합하게 이용된다.

본 발명에서는, 안티센스쇄 핵산에 의해 APCS 유전자의 발현을 억제할 수 있다.

본 발명의 이중쇄 핵산은, 센스쇄 핵산 및 안티센스쇄 핵산으로 이루어지고, 적어도 11개의 염기쌍의 이중쇄 영역을 포함하는 이중쇄 핵산으로서, 상기 안티센스쇄 핵산 중의, 적어도 17개의 뉴클레오티드이며 많아도 30개의 뉴클레오티드의 쇄길이의 올리고뉴클레오티드쇄에 있어서, 서열 번호 1288∼1930 중 어느 것으로 표시되는 염기 서열을 포함하는 표적 APCS mRNA 서열과 상보적인 APCS 유전자의 발현을 억제하는 이중쇄 핵산이다.

서열 번호 1288∼1930 중 어느 것으로 표시되는 염기 서열은, 표 1에 기재된다.

본 발명의 이중쇄 핵산에 있어서, 센스쇄 핵산 및 안티센스쇄 핵산은, 어느 뉴클레오티드 또는 뉴클레오티드 유도체로 구성되어도 좋다.

본 발명의 이중쇄 핵산에서의 안티센스쇄 핵산으로는, 표적 APCS mRNA 서열에 대하여 상보적인 염기 서열을 포함하는 뉴클레오티드쇄가 이용된다.

표적 APCS mRNA 서열은, 서열 번호 1에 상동이며, 서열 번호 1에서의 T가 U로 갱신된 APCS mRNA의 염기 서열 중, 서열 번호 1288∼1930 중 어느 것으로 표시되는 염기 서열을 포함한다. 바람직하게는, 표적 APCS mRNA 서열은, 서열 번호 1에 상동이며, 서열 번호 1에서의 T가 U로 갱신된 APCS mRNA의 염기 서열 중, 서열 번호 1288∼1930 중 어느 것으로 표시되는 염기 서열이다.

본 발명의 이중쇄 핵산에서의 안티센스쇄 핵산을 구성하는 뉴클레오티드 중, 적어도 17개의 뉴클레오티드이며 많아도 30개의 뉴클레오티드의 쇄길이의 올리고뉴클레오티드쇄가, 표적 APCS mRNA 서열과 상보적이다.

본 발명에서 안티센스쇄 핵산을 구성하는 뉴클레오티드 중, 바람직하게는 11∼27개의 뉴클레오티드, 보다 바람직하게는 15∼25개의 뉴클레오티드, 더욱 바람직하게는 15∼23개의 뉴클레오티드, 특히 바람직하게는 17∼21개의 뉴클레오티드, 특히 더 바람직하게는 17∼19개의 뉴클레오티드, 특히 더 바람직하게는 19개의 뉴클레오티드의 쇄길이의 올리고뉴클레오티드쇄에 있어서, 표적 APCS mRNA 서열과 상보적이다.

본 발명에 있어서 안티센스쇄 핵산과 센스쇄 핵산은, 적어도 11개의 염기쌍의 이중쇄 영역을 포함하고, 이중쇄 영역은, 통상 11∼30개의 뉴클레오티드, 바람직하게는 11∼27 염기쌍이며, 보다 바람직하게는 15∼25 염기쌍, 더욱 바람직하게는 15∼23 염기쌍, 특히 바람직하게는 17∼21 염기쌍, 특히 더 바람직하게는 17∼19 염기쌍, 특히 더 바람직하게는 19 염기쌍이다.

본 발명에 있어서, 이중쇄 영역 내의 뉴클레오티드에 대하여, 2'-수식 뉴클레오티드를 포함하는 것이 바람직하고, 어느 부위에 포함하는 것이어도 좋다. 또한, 적합한 2'-수식 뉴클레오티드의 함유량으로서, 뉴클레오티드의 총량(100%)에 대하여, 10∼20%이어도 좋고, 20∼40%이어도 좋고, 40∼65%이어도 좋다.

2'-수식 뉴클레오티드를 포함하는 이중쇄 핵산으로서 구체적으로는, 예컨대, 표 3에 기재된 센스쇄/안티센스쇄로 이루어진 군에서 선택되는 1쌍의 센스쇄/안티센스쇄의 서열로 이루어진 이중쇄 핵산을 들 수 있다.

본 발명에 있어서, 센스쇄 핵산의 뉴클레오티드에 대하여, 적합한 2'-수식 뉴클레오티드의 함유량으로서, 20∼40%이어도 좋고, 40∼60%이어도 좋고, 60%∼100%이어도 좋다.

본 발명에 있어서, 안티센스쇄 핵산의 뉴클레오티드에 대하여, 적합한 2'-수식 뉴클레오티드의 함유량으로서, 0∼40%인 것이 바람직하고, 10∼20%이어도 좋고, 20∼40%이어도 좋다.

이중쇄 핵산을 구성하는 단일쇄의 안티센스쇄 핵산 및 센스쇄 핵산은, 각각, 통상 17∼30 염기로 이루어지지만, 17∼27 염기로 이루어진 것이 바람직하고, 17∼25 염기로 이루어진 것이 보다 바람직하고, 17∼25 염기로 이루어진 것이 더욱 바람직하고, 19∼25 염기로 이루어진 것이 특히 바람직하다. 안티센스쇄 핵산과 센스쇄 핵산의 염기 길이는, 동일해도 좋고 상이해도 좋다.

본 발명에서는, 안티센스쇄 핵산은, 서열 번호 645∼1287 및 1975∼2018 중 어느 것으로 표시되는 염기 서열을 포함하는 것이 바람직하고, 센스쇄 핵산은, 서열 번호 2∼644 및 1931∼1974 중 어느 것으로 표시되는 염기 서열을 포함하는 것이 바람직하다.

본 발명에서는, 안티센스쇄 핵산은, 서열 번호 645∼1287 및 1975∼2018 중 어느 것으로 표시되는 염기 서열을 갖는 뉴클레오티드쇄인 것이 보다 바람직하고, 센스쇄 핵산은, 서열 번호 2∼644 및 1931∼1974 중 어느 것으로 표시되는 염기 서열을 갖는 뉴클레오티드쇄인 것이 보다 바람직하다.

본 발명의 이중쇄 핵산은, 센스쇄 핵산은, 서열 번호 2∼644 및 1931∼1974 중 어느 것으로 표시되는 염기 서열을 포함하고, 그것에 대응하여, 안티센스쇄 핵산은, 서열 번호 645∼1287 및 1975∼2018 중 어느 것으로 표시되는 염기 서열을 포함하는 것이 바람직하다.

본 명세서에 있어서, 그것에 대응하여란, 표 1 또는 표 3에서 이중쇄 핵산 번호로서 기재되는 가로 1열의 컬럼에서의 센스쇄 핵산과 안티센스쇄 핵산의 조합인 것을 의미하며, 서열 번호 n(n=2∼644)에 대응하는 서열 번호는 n+643이 된다. 구체적으로 예시하여 설명하면, 서열 번호 2에 대응하는 서열 번호는 645이다.

본 발명의 이중쇄 핵산은, 센스쇄 핵산은, 서열 번호 2∼644 및 1931∼1974 중 어느 것으로 표시되는 염기 서열을 갖는 뉴클레오티드쇄이며, 그것에 대응하여, 안티센스쇄 핵산은, 서열 번호 645∼1287 및 1975∼2018 중 어느 것으로 표시되는 염기 서열을 갖는 뉴클레오티드쇄인 것이 보다 바람직하다.

본 발명의 이중쇄 핵산에 있어서, 이중쇄 영역에 계속되는 3' 말단측 또는 5' 말단측에 이중쇄를 형성하지 않는 추가의 뉴클레오티드 또는 뉴클레오티드 유도체를 갖는 경우에는, 이 이중쇄를 형성하지 않는 뉴클레오티드 또는 뉴클레오티드 유도체를 돌출부(오버행)라고 부른다. 돌출부를 갖는 경우에는, 돌출부를 구성하는 뉴클레오티드는 리보뉴클레오티드, 데옥시리보뉴클레오티드 또는 이들의 유도체이어도 좋다.

돌출부를 갖는 이중쇄 핵산으로는, 센스쇄 핵산 및 안티센스쇄 핵산의 적어도 한쪽의 핵산의 3' 말단 또는 5' 말단에, 통상 1∼6 염기, 바람직하게는 1∼3 염기로 이루어진 돌출부를 갖는 것이 이용되지만, 2 염기로 이루어진 돌출부를 갖는 것이 보다 바람직하게 이용되며, 예컨대 dTdT(dT는 티미딘을 나타냄) 또는 UU로 이루어진 돌출부를 갖는 것을 들 수 있다. 돌출부는, 안티센스쇄 핵산에만, 센스쇄 핵산에만, 및 안티센스쇄 핵산과 센스쇄 핵산의 모두에 가질 수 있다. 또한, 돌출부가, 안티센스쇄 핵산에만 갖는 경우, 센스쇄 핵산에만 갖는 경우, 및 안티센스쇄 핵산과 센스쇄 핵산의 모두에 갖는 경우의 어느 경우에 관해서도, 핵산의 3' 말단 및/또는 5' 말단에 돌출부를 갖고 있어도 좋다.

본 발명에서 이용되는 안티센스쇄 핵산은, 바람직하게는, 센스쇄 핵산과의 이중쇄 영역과 그것에 계속되는 돌출부를 포함하는, 적어도 17개의 뉴클레오티드이며 많아도 30개의 뉴클레오티드로 이루어진 올리고뉴클레오티드쇄에 있어서 서열 번호 1288∼1930 중 어느 것으로 표시되는 염기 서열을 포함하는 표적 APCS mRNA 서열과 충분히 상보적이다.

본 발명의 이중쇄 핵산으로는, 예컨대 Dicer 등의 리보뉴클레아제의 작용에 의해 상기 이중쇄 핵산을 생성하는 핵산 분자(WO2005/089287)나, 3' 말단이나 5' 말단의 돌출부를 갖지 않고 평활 말단을 형성하는 이중쇄 핵산, 센스쇄 핵산만이 돌출된 이중쇄 핵산(US2012/0040459) 등을 이용할 수도 있다. 본 발명에서 「평활 말단」이란, 이중쇄 핵산의 말단에 돌출부를 갖지 않는 것을 가리킨다. 평활 말단으로서, 예컨대, 센스쇄 핵산의 3' 말단 및 안티센스쇄 핵산의 5' 말단의 모두, 및/또는, 센스쇄 핵산의 5' 말단 및 안티센스쇄 핵산의 3' 말단의 모두에 돌출부를 갖지 않는 이중쇄 핵산이 있다.

본 발명에서는, 센스쇄 핵산의 3' 말단 및 안티센스쇄 핵산의 5' 말단, 및/또는, 센스쇄 핵산의 5' 말단 및 안티센스쇄 핵산의 3' 말단이, 평활 말단을 형성하는 것이 바람직하다. 특히, 센스쇄 핵산의 3' 말단 및 안티센스쇄 핵산의 5' 말단, 또는, 센스쇄 핵산의 5' 말단 및 안티센스쇄 핵산의 3' 말단이, 평활 말단을 형성하는 것이 보다 바람직하다. 센스쇄 핵산의 3' 말단 및 안티센스쇄 핵산의 5' 말단, 및/또는, 센스쇄 핵산의 5' 말단 및 안티센스쇄 핵산의 3' 말단이 평활 말단을 형성하는 경우에는, 센스쇄 핵산은 21개의 뉴클레오티드의 쇄길이를 가지며, 또한 안티센스쇄 핵산은 23개의 뉴클레오티드의 쇄길이를 갖는 것이 바람직하다.

본 발명에서는, 안티센스쇄 핵산과 센스쇄 핵산의 모두에 돌출부를 갖는 이중쇄 핵산도 바람직하다. 센스쇄 핵산의 3' 말단 및 안티센스쇄 핵산의 3' 말단, 또는, 센스쇄 핵산의 5' 말단 및 안티센스쇄 핵산의 5' 말단이, 돌출부를 갖는 것이 바람직하다. 안티센스쇄 핵산과 센스쇄 핵산의 모두에 돌출부를 갖는 경우, 센스쇄 핵산은 21개의 뉴클레오티드의 쇄길이를 가지며, 또한 안티센스쇄 핵산은 21개의 뉴클레오티드의 쇄길이를 갖는 것이 바람직하다.

본 발명에서는, 센스쇄 핵산의 3' 말단 및 5' 말단의 모두, 또는, 상기 안티센스쇄 핵산의 3' 말단 및 5' 말단의 모두가, 돌출부를 갖는 것도 보다 바람직하다.

본 발명의 안티센스쇄 핵산의 5' 말단으로부터 2번째의 뉴클레오티드는, 표적 APCS mRNA 서열의 3' 말단으로부터 2번째의 리보뉴클레오티드와 완전히 상보인 것이 바람직하고, 안티센스쇄 핵산의 5' 말단으로부터 2∼7번째의 리보뉴클레오티드가, 각각 표적 APCS mRNA 서열의 3' 말단으로부터 2∼7번째의 리보뉴클레오티드와 완전히 상보인 것이 보다 바람직하고, 안티센스쇄 핵산의 5' 말단으로부터 2∼11번째의 리보뉴클레오티드가, 각각 표적 APCS mRNA 서열의 3' 말단으로부터 2∼11번째의 리보뉴클레오티드와 완전히 상보인 것이 더욱 바람직하다.

본 발명에서의 안티센스쇄 핵산의 5' 말단으로부터 11번째의 뉴클레오티드가, 표적 APCS mRNA 서열의 3' 말단으로부터 11번째의 리보뉴클레오티드와 완전히 상보인 것이 바람직하고, 안티센스쇄 핵산의 5' 말단으로부터 9∼13번째의 리보뉴클레오티드가, 각각 표적 APCS mRNA 서열의 3' 말단으로부터 9∼13번째의 리보뉴클레오티드와 완전히 상보인 것이 보다 바람직하고, 안티센스쇄 핵산의 5' 말단으로부터 7∼15번째의 리보뉴클레오티드가, 각각 표적 APCS mRNA 서열의 3' 말단으로부터 7∼15번째의 리보뉴클레오티드와 완전히 상보인 것이 더욱 바람직하다.

본 발명의 핵산을 제조하는 방법으로는, 특별히 한정되지 않고, 공지의 화학 합성을 이용하는 방법 또는 효소적 전사법 등을 들 수 있다.

공지의 화학 합성을 이용하는 방법으로서, 포스포로아미다이트법, 포스포로티오에이트법, 포스포트리에스테르법 및 CEM법[Nucleic Acid Research, 35, 3287(2007)] 등을 들 수 있고, 예컨대, ABI3900 하이스루풋 핵산 합성기(어플라이드 바이오 시스템즈사 제조)에 의해 본 발명의 핵산을 합성할 수 있다. 합성이 종료한 후에는, 고상으로부터의 이탈, 보호기의 탈보호 및 목적물의 정제 등을 행한다. 정제에 의해, 순도 90% 이상, 바람직하게는 95% 이상의 핵산을 얻는 것이 바람직하다.

이중쇄 핵산의 경우에는, 합성 및 정제한 센스쇄 핵산 및 안티센스쇄 핵산을 적당한 비율, 예컨대, 안티센스쇄 핵산 1 당량에 대하여, 센스쇄 핵산 0.1∼10 당량, 바람직하게는 0.5∼2 당량, 보다 바람직하게는 0.9∼1.1 당량, 더욱 바람직하게는 등몰량으로 혼합한 후, 통상 혼합한 것을 어닐링하지만, 어닐링하는 공정을 생략하고 혼합한 것을 직접 이용해도 좋다.

어닐링은, 이중쇄 핵산을 형성할 수 있는 조건이라면 어떠한 조건으로 행해도 좋지만, 통상, 안티센스쇄 핵산 및 센스쇄 핵산을 거의 등몰량으로 혼합한 후, 94℃ 정도에서 5분 정도 가열한 후, 실온까지 서냉하는 것에 의해 행해진다.

효소적 전사법으로는, 목적으로 하는 염기 서열을 갖는 플라스미드 또는 DNA를 주형으로 하여 퍼지 RNA 폴리머라제, 예컨대, T7, T3 또는 SP6RNA 폴리머라제를 이용한 전사에 의한 방법을 들 수 있다.

본 발명의 핵산은, 트랜스펙션용의 담체, 바람직하게는 양이온성 리포좀 등의 양이온성 담체를 이용하여 세포 내에 도입할 수 있다. 또한, 인산칼슘법, 일렉트로포레이션법, 또는 마이크로인젝션법 등에 의해, 직접 세포 내에 도입할 수도 있다.

본 발명의 핵산은 리간드를 포함해도 좋다. 본 발명의 핵산은, 5' 말단 및/혹은 3' 말단으로부터, 및/또는 서열 내부에서 하나 또는 복수의 리간드나 형광단에 의해 수식되어 있어도 좋으며, 리간드나 형광단에 의해 수식된 핵산을 콘쥬게이트 핵산이라고도 한다. 고상 상에서의 신장 반응시에, 고상 상에서 반응 가능한 수식제를 반응시킴으로써, 5' 말단 및/혹은 3' 말단, 및/또는 서열 내부에 수식을 할 수 있다. 또한, 아미노기, 머캅토기, 아지드기 또는 삼중 결합 등의 작용기를 도입한 핵산을 미리 합성 및 정제해 두고, 이들 작용기로 수식화제를 작용시킴으로써 콘쥬게이트 핵산을 얻을 수도 있다. 리간드로는, 생체 분자와 친화성이 있는 분자이면 되지만, 예컨대 콜레스테롤, 지방산, 토코페롤 및 레티노이드 등의 지질류, N-아세틸갈락토사민(GalNAc), 갈락토스(Gal) 및 만노스(Man) 등의 당류, 완전 항체, scFV, Fab 및 VHH 등의 프래그먼트 항체, 저밀도 리포단백질(LDL) 및 인간 혈청 알부민 등의 단백질, RGD, NGR, R9 및 CPP 등의 펩티드류, 엽산 등의 저분자, 합성 폴리아미노산 등의 합성 폴리머, 및 핵산 압타머 등을 들 수 있고, 이들을 조합하여 이용할 수도 있다. 형광단으로는 Cy3 시리즈, Alexa(등록상표) 시리즈 및 블랙홀 켄처(등록상표) 등을 들 수 있다. 본 발명의 핵산에 리간드를 부가하는 방법으로는, 예컨대, 고상 상에서의 신장 반응시에, 고상 상에서 반응 가능한 수식제를 반응시킴으로써, 5' 말단, 3' 말단 및/또는 서열 내부에 수식을 할 수 있지만, 이것에 한정되지 않는다. 또한, 아미노기, 머캅토기, 아지드기 또는 3중 결합 등의 작용기를 도입한 핵산을 미리 합성 및 정제해 두고, 이들에 수식제를 작용시킴으로써 얻을 수도 있다.

본 발명의 핵산 대신에, 세포 내에 도입하여 이들이 발현되는 벡터를 이용해도 좋다. 구체적으로는, 본 발명의 핵산을 코드하는 서열을 발현 벡터 내의 프로모터 하류에 삽입하여 발현 벡터를 구축하고, 세포에 도입하는 것에 의해 상기 핵산 등을 발현시킬 수 있다. 발현 벡터로는, pcDNA6.2-GW/miR(Invitrogen사 제조), pSilencer 4.1-CMV(Ambion사 제조), pSINsi-hH1 DNA(다카라바이오사 제조), pSINsi-hU6 DNA(다카라바이오사 제조) 및 pENTR/U6(Invitrogen사 제조) 등을 들 수 있다.

세포 내에서 본 발명의 핵산이 발현된다는 점에서, 상기 벡터를 이용하는 것은 본 발명의 핵산의 기술적 범위에 포함된다.

본 발명의 핵산을 코드하는 서열을 바이러스 벡터 내의 프로모터 하류에 삽입하고, 상기 벡터를 패키징 세포에 도입하여 생성한 재조합 바이러스 벡터를 이용할 수도 있다. 바이러스 벡터로는, 레트로바이러스 벡터, 렌치바이러스 벡터, 아데노바이러스 벡터 및 아데노 수반 바이러스 벡터 등을 들 수 있다.

2. APCS의 발현 억제 활성을 갖는 핵산

본 발명에서의 안티센스쇄 핵산 및 센스쇄 핵산은, 예컨대, Genbank 수탁 번호 NM_001639.3으로서 등록되어 있는 인간 APCS의 완전 길이 mRNA의 APCS 2nd 스트랜드 cDNA의 염기 서열(서열 번호 1)에 기초하여 설계할 수 있다. 또, 인간의 APCS의 완전 길이 mRNA의 cDNA의 염기 서열과 인간 이외의 생물종의 APCS의 완전 길이 mRNA의 cDNA의 염기 서열을 비교하는 것에 의해, 인간 이외의 생물종에서 APCS mRNA의 발현을 억제하는 안티센스쇄 핵산 및 센스쇄 핵산을 설계할 수도 있다.

APCS의 발현 억제 활성을 갖는 핵산으로는, APCS mRNA 서열에 대하여 상보적인 염기 서열을 포함하는 본 발명의 안티센스쇄 핵산과, 상기 안티센스쇄 핵산의 염기 서열에 대하여 상보적인 염기 서열을 포함하는 본 발명의 센스쇄 핵산으로 이루어지고, 또한 APCS의 발현 억제 활성을 갖는 이중쇄 핵산을 들 수 있다.

본 발명의 이중쇄 핵산을 세포에 도입하는 것에 의해, APCS의 발현을 억제할 수 있다. 예컨대 본 발명의 이중쇄 핵산은, 수 pM∼수 nM의 농도로 세포에 도입한 후, 24시간 이상, 예컨대 48시간 배양한 단계에서 APCS의 mRNA의 발현을 억제할 수 있다.

본 발명의 이중쇄 핵산의 APCS의 mRNA의 발현 억제 활성의 평가는, 상기 핵산 등을 인간 세포주 등에 양이온성 리포좀 등을 이용하여 트랜스펙션하여 일정 시간 배양한 후, 상기 인간 세포주에서의 APCS의 mRNA의 발현량을 정량하는 것에 의해 행할 수 있다.

본 발명의 이중쇄 핵산의 APCS mRNA의 발현 억제 활성의 평가는, 상기 핵산 등을 인간 세포주 등에 양이온성 리포좀 등을 이용하여 트랜스펙션하여 일정 시간 배양한 후, 상기 인간 세포주에서의 APCS의 mRNA의 발현량을 정량하는 것에 의해 행할 수 있다.

APCS의 발현 억제 활성을 갖는 핵산으로는, 상기 이중쇄 핵산 이외에도, APCS mRNA의 일부의 염기 서열에 대하여 상보적인 염기 서열을 포함하는 핵산이자, APCS의 발현을 억제하는 단일쇄 핵산을 들 수 있다. 상기 단일쇄 핵산은, 통상 8∼30 염기로 이루어지지만, 12∼30 염기로 이루어진 것이 바람직하고, 12∼20 염기로 이루어진 것이 보다 바람직하다.

또한, 상기 단일쇄 핵산으로는, 예컨대, 본 발명의 이중쇄 핵산에서의 안티센스쇄 핵산인 단일쇄 핵산을 들 수 있다.

단일쇄 핵산인 본 발명에서의 안티센스쇄 핵산도 세포에 도입하는 것에 의해, APCS의 발현을 억제할 수 있다. 예컨대 본 발명의 단일쇄 핵산은, 수 pM∼수 μM의 농도로 세포에 도입한 후, 24시간 이상, 예컨대 48시간 배양한 단계에서 APCS의 mRNA의 발현을 억제할 수 있다.

본 발명의 안티센스쇄 핵산의 APCS의 mRNA의 발현 억제 활성의 평가는, 상기 핵산 등을 인간 세포주 등에 양이온성 리포좀 등을 이용하여 트랜스펙션하여 일정 시간 배양한 후, 상기 인간 세포주에서의 APCS의 mRNA의 발현량을 정량하는 것에 의해 행할 수 있다.

3. 본 발명의 의약 조성물

본 발명은, 본 발명의 이중쇄 핵산 및 단일쇄 핵산 등의 핵산을 유효 성분으로서 함유하는 의약 조성물에 관한 것이기도 하다. 본 발명의 의약 조성물은, 아밀로이드 관련 질환의 치료제 또는 예방제로서 이용할 수 있다.

또한, 본 발명에서는, APCS를 포함한 아밀로이드 섬유에 의해 매개되는 장해를 치료하는 방법도 제공한다. 상기 치료 방법에서는, 본 발명의 핵산 또는 본 발명의 의약 조성물을, 그와 같은 치료를 필요로 하는 인간에게 투여하는 것에 의해, APCS를 포함한 아밀로이드 섬유에 의해 매개되는 장해를 치료할 수 있다.

APCS를 포함한 아밀로이드 섬유에 의해 매개되는 장해로는, 예컨대, 아밀로이드 관련 질환을 들 수 있다. 본 발명의 이중쇄 핵산은, 단독으로 치료 방법에 이용할 수도 있지만, 이하에 나타내는 바와 같이, 본 발명의 의약 조성물에서의 유효 성분으로서 인간에게 투여하는 것에 의해 약효를 발휘시킬 수 있다.

본 발명의 의약 조성물은, 본 발명의 핵산을 세포 내로 이행시키는 데 유효한 담체를 더 포함할 수 있다. 핵산을 세포 내로 이행시키는 데 유효한 담체로는, 예컨대 양이온성 담체를 들 수 있다. 양이온성 담체로는, 양이온성 리포좀 및 양이온성 폴리머 등을 들 수 있다. 또한, 핵산을 세포 내로 이행시키는 데 유효한 담체로서, 바이러스 엔벨로프를 이용한 담체를 이용해도 좋다. 양이온성 폴리머로는, 예컨대 JetSI(Qbiogene사) 및 Jet-PEI(폴리에틸렌이민; Qbiogene사) 등을 들 수 있다. 바이러스 엔벨로프를 이용한 담체로는, 예컨대 GenomeOne(HVJ-E 리포좀; 이시하라 산업사) 등을 들 수 있다.

본 발명의 핵산과 상기 담체를 포함하는 의약 조성물은, 당업자에게 이미 알려진 방법에 의해 조제할 수 있다. 예컨대, 적당한 농도의 담체 분산액과 핵산 용액을 혼합하여 본 발명의 의약 조성물을 조제할 수 있다. 양이온성 담체를 이용하는 경우, 핵산은 통상 수용액 중에서 부전하를 띠고 있기 때문에, 통상의 방법으로 수용액 중에서 혼합함으로써 용이하게 본 발명의 의약 조성물을 조제할 수 있다. 의약 조성물을 조제하기 위해 이용하는 수성 용매로는, 주사용수, 주사용 증류수, 생리 식염수 등의 전해질액, 및 포도당액 및 말토스액 등의 당액 등을 들 수 있다. 또한, 본 발명의 의약 조성물을 조제할 때의 pH 및 온도 등의 조건은 당업자가 적절하게 선택할 수 있다. 의약 조성물은, 필요하다면 초음파 분산 장치나 고압 유화 장치 등을 이용하여 분산 처리를 행하는 것에 의해, 균일한 조성물로 할 수도 있다. 본 발명의 핵산과 담체를 포함하는 의약 조성물의 조제에 최적인 방법 및 조건은, 이용하는 담체에 의존하기 때문에, 상기 방법에 구애되지 않으며, 당업자라면 이용하는 담체에 최적인 방법을 선택할 수 있다.

또한, 본 발명의 의약 조성물로는, 예컨대 핵산과 리드 입자를 구성 성분으로 하는 복합 입자 및 복합 입자와 필요에 따라 상기 복합 입자를 피복하는 지질막으로 구성되는 조성물도 적합하게 이용된다. 리드 입자로는, 예컨대 지질 집합체, 리포좀, 에멀젼 입자, 고분자, 금속 콜로이드 및 미립자 제제 등을 들 수 있고, 바람직하게는 리포좀이 이용되고, 보다 바람직하게는 양이온성 리포좀이 이용된다. 본 발명에서의 리드 입자는, 지질 집합체, 리포좀, 에멀젼 입자, 고분자, 금속 콜로이드 및 미립자 제제 등을 2개 이상 조합한 복합체를 구성 성분으로 하고 있어도 좋고, 지질 집합체, 리포좀, 에멀젼 입자, 고분자, 금속 콜로이드 및/또는 미립자 제제 등과 다른 화합물(예컨대 당, 지질 및 무기 화합물 등)을 조합한 복합체를 구성 성분으로 하고 있어도 좋다.

상기 복합 입자를 피복하는 지질막으로는, 예컨대 비양이온성 지질, 입자의 응집을 저지하는 지질 및 양이온성 지질 등을 구성 성분으로 하는 것을 들 수 있다.

본 발명의 의약 조성물은, 예컨대 국제 공개 제2006/080118호 등에 기재된 방법에 따라서 조제할 수 있다.

본 발명의 의약 조성물에 포함되는 핵산과 담체의 배합비는, 통상, 핵산 1 질량부에 대하여 담체 1∼200 중량부가 적당하다. 상기 배합비는, 핵산 1 질량부에 대하여, 바람직하게는 담체 2.5∼100 질량부이고, 보다 바람직하게는 담체 7∼25 질량부이다.

본 발명의 의약 조성물을 구성하는 입자의 크기는, 평균 입자 직경이 약 10 nm∼300 nm인 것이 바람직하고, 약 30 nm∼200 nm인 것이 보다 바람직하고, 약 50 nm∼150 nm인 것이 더욱 바람직하다.

본 발명의 의약 조성물에는, 상기 담체 외에, 의약적으로 허용할 수 있는 캐리어 또는 희석제 등을 포함하고 있어도 좋다. 의약적으로 허용할 수 있는 캐리어 또는 희석제 등은, 본질적으로 화학적으로 불활성 및 무해한 화합물(조성물인 경우를 포함)이며, 본 발명의 의약 조성물의 생물학적 활성에 영향을 미치지 않는 것이다. 의약적으로 허용할 수 있는 캐리어 또는 희석제로는, 예컨대 염용액, 당용액, 글리세롤 용액 및 에탄올 등이 있지만, 이들에 한정되지 않는다.

본 발명의 의약 조성물은, 질환의 치료 또는 예방에 유효한 양의 핵산을 포함하고, 또한, 환자에게 적절히 투여할 수 있는 형태로 제공된다. 본 발명의 의약 조성물의 제제 형태는, 예컨대 주사제, 점안제 및 흡입용 등의 액제 및 예컨대 연고 및 로션제 등의 외용제 등이어도 좋다.

액제의 경우, 본 발명의 의약 조성물 중의 유효 성분인 본 발명의 핵산의 농도 범위는 통상 0.001∼25%(w/v)이며, 바람직하게는 0.1∼10%(w/v)이고, 보다 바람직하게는 0.5∼5%(w/v)이다. 본 발명의 의약 조성물은 의약적으로 허용되는 임의의 첨가제, 예컨대, 유화 보조제, 안정화제, 등장화제 및/또는 pH 조정제 등을 적당량 함유하고 있어도 좋다. 의약적으로 허용되는 임의의 첨가제는, 상기 복합체의 분산전에도, 분산후에라도 적당한 공정에서 첨가할 수 있다.

액제의 pH는, 통상 약 5.0∼약 8.5, 바람직하게는 약 6.0∼약 8.0으로 조정된다.

액제는, 바람직하게는 멤브레인 필터 등을 이용한 여과 멸균 등의 멸균 처리를 행한다.

본 발명의 의약 조성물은, 동결 건조 제제로서 조제할 수도 있다. 동결 건조 제제는, 핵산과 담체를 분산 처리한 후 동결 건조 처리하는 것에 의해 조제할 수 있다. 동결 건조 처리는 통상의 방법으로 행할 수 있다. 예컨대, 상기 분산 처리후의 복합체 용액을 무균 상태로 소정량을 바이알병에 분주(分注)하여, 약 -40∼-20℃의 조건으로 예비 건조를 약 2시간 정도 행하고, 약 0∼10℃에서 감압하에 1차 건조를 행하고, 이어서, 약 15∼25℃에서 감압하에 2차 건조하여 동결 건조할 수 있다. 그리고, 예컨대 바이알 내부를 질소 가스로 치환하고, 마개로 막는 것에 의해, 본 발명의 의약 조성물의 동결 건조 제제를 얻을 수 있다.

동결 건조 제제는, 임의의 적당한 용액의 첨가에 의해 재용해하여 사용할 수 있다. 이러한 용액으로는, 예컨대 주사용수, 생리식염수 등의 전해질액, 포도당액 및 기타 일반 수액 등을 들 수 있다. 이용되는 용액의 액량은 용도 등에 따라 다르며, 특별히 제한되지 않지만, 동결 건조전의 액량의 0.5∼2배량, 또는 500 mL 이하가 바람직하다.

본 발명의 의약 조성물은, 인간을 포함하는 동물에 대하여, 예컨대 정맥내 투여, 동맥내 투여, 경구 투여, 조직내 투여, 경피 투여, 경점막 투여 또는 경직장 투여할 수 있지만, 환자의 증상에 맞춘 적절한 방법에 의해 투여하는 것이 바람직하다. 특히 정맥내 투여, 경피 투여 및 경점막 투여가 바람직하게 이용된다. 또한, 암내 국소 투여 등 국소 투여를 할 수도 있다. 이러한 투여 방법에 적합한 제형으로는, 예컨대 각종 주사제, 경구제, 점적제, 흡수제, 점안제, 연고제, 로션제 및 좌제 등을 들 수 있다.

본 발명의 의약 조성물의 용량은, 약물, 제형, 연령 및 체중 등의 환자의 상태, 투여 경로 및 질환의 성질과 정도 등을 고려한 뒤에 결정하는 것이 바람직하지만, 통상은 핵산의 질량으로서, 성인에 대하여 1일당 통상 0.1 mg∼10 g/일, 바람직하게는 1 mg∼500 mg/일이다. 경우에 따라서는, 그 이하이어도 충분하고, 또한 반대로 그 이상의 용량을 필요로 할 수도 있다. 또한 하루 1회∼수회 투여할 수도 있고, 하루∼수일의 간격을 두고 투여할 수도 있다.

실시예

이하에, 본 발명을 실시예에 의해 설명한다. 다만, 본 발명은 이들 실시예에 한정되는 것이 아니다.

실시예 1 이중쇄 핵산의 합성

시그마 알드리치사에 의뢰하여, 서열 번호 2∼644에 나타내는 리보뉴클레오티드로 이루어진 센스쇄 핵산, 서열 번호 645∼1287에 나타내는 리보뉴클레오티드로 이루어진 안티센스쇄 핵산, 및 이들을 어닐링시킨 이중쇄 핵산(서열 번호 n(n=2∼644)에 나타내는 센스쇄 핵산과 서열 번호[n+643]에 나타내는 안티센스쇄 핵산이 쌍을 이루는)을 합성했다.

실시예 2 APCS mRNA의 녹다운 활성의 측정

384 웰의 배양 플레이트에, 실시예 1에서 합성한 이중쇄 핵산과 RNAiMax 트랜스펙션 시약(Thermo Fisher Scientific사 제조, 카탈로그 번호 13778150)을 Opti-MEM I Reduced Serum Medium 배지(Thermo Fisher Scientific사 제조, 카탈로그 번호 31985070)로 희석한 siRNA/RNAiMax 혼합액 20 μL을 첨가했다. 인간 난소암 유래의 세포주인 RMG-I 세포(JCRB 세포 뱅크, JCRB0172)를, 10,000 세포/40 μL/웰이 되도록 각각 384 웰의 배양 플레이트에 파종하여, 37℃, 5% CO₂조건하에 24시간 배양했다. 배지는, 10% 소태아 혈청(Thermo Fisher Scientific사 제조, 카탈로그 번호 10091-148)을 포함하는 Ham's F-12 Nutrient Mix 배지(Thermo Fisher Scientific사 제조, 카탈로그 번호 11765-047)를 이용했다. 이중쇄 핵산의 종농도는 1 nM이 되도록 했다. 그 후, 세포를 DPBS, 무칼슘, 무마그네슘(Thermo Fisher Scientific사 제조, 카탈로그 번호 14190-144)으로 세정하고, 각각의 플레이트로부터 TaqMan(등록상표) Fast Cells-to-CT(상표) 키트(Thermo Fisher Scientific사 제조, 카탈로그 번호 4399003)를 이용하여 이하의 방법으로 cDNA를 합성했다. 용해 용액(키트 내용물)과 DNase I(키트 내용물)를 100:1로 혼합한 용액을 10 μL씩 첨가하여 5분간 혼합했다. 정지 용액(키트 내용물)을 1 μL씩 첨가, 2분간 혼합하여, RNA 추출액으로 했다. 5 μL의 2×RT 버퍼(키트 내용물), 0.5 μL의 20×RT Enzyme Mix(키트 내용물), 2.5 μL의 Nuclease-free Water, 2 μL의 RNA 추출액을 혼합하고, 이것을 37℃ 60분, 95℃ 5분간 반응시켜, cDNA를 합성했다. 이 cDNA 2 μL을 MicroAmp(등록상표) EnduraPlate(상표) Optical 384-Well Clear Reaction Plates with Barcode(Thermo Fisher Scientific사 제조, 카탈로그 번호 4483285)에 가하고, 또한 5 μL의 TaqMan(등록상표) Fast Universal PCR Master Mix(Thermo Fisher Scientific사 제조, 카탈로그 번호 4352042), 2.5 μL의 DISTILLED WATER(ULTRAPURE)(Thermo Fisher Scientific사 제조, 카탈로그 번호 10977015), 0.25 μL의 인간 APCS 프로브, 0.25 μL의 인간 ACTB 프로브를 첨가했다. QuantStudio(상표) 7 Flex를 이용하여, 인간 APCS 유전자 및 인간 ACTB(액틴 베타) 유전자의 실시간 PCR을 행했다. ACTB는 구성적 발현 유전자이며 내부 대조로서 측정하여, APCS 유전자 발현량을 보정했다. siRNA를 첨가하지 않고 트랜스펙션 시약만으로 RMG-I 세포를 처리했을 때의 APCS mRNA량을 1.0으로 하여, 각 siRNA를 도입했을 때의 APCS mRNA 상대 발현량치를 산출했다. 본 실험을 2회 행하여, APCS mRNA 상대 발현량치의 최소치를 표 1에 나타냈다. 표 1은, 편의상 이하와 같이 분할하여 나타낸다.

[표 1-1]

[표 1-2]

[표 1-3]

[표 1-4]

[표 1-5]

[표 1-6]

[표 1-7]

[표 1-8]

[표 1-9]

[표 1-10]

[표 1-11]

[표 1-12]

[표 1-13]

[표 1-14]

[표 1-15]

[표 1-16]

또, APCS 2nd 스트랜드 cDNA의 전체 길이의 염기 서열을 표 2에 나타낸다.

[표 2]

실시예 3 화학 수식한 이중쇄 핵산의 녹다운 활성

진디자인사에 의뢰하여, 서열 번호 1931∼1974에 나타내는 리보뉴클레오티드로 이루어진 센스쇄 핵산, 서열 번호 1975∼2018에 나타내는 리보뉴클레오티드로 이루어진 안티센스쇄 핵산, 및 이들을 어닐링시킨 이중쇄 핵산(서열 번호 n(n=1931∼1974)에 나타내는 센스쇄와 서열 번호[n+44]에 나타내는 안티센스쇄가 쌍을 이룬다)을 합성했다.

합성한 이중쇄 핵산의 종농도는 1 nM 또는 0.1 nM이 되도록 하고, 상기 이중쇄 핵산을 RMG-1 세포에 도입하여 24시간 배양한 것 외에는, 실시예 2와 동일하게 조작하여 APCS mRNA 상대 발현량을 산출했다. 본 실험을 4회 행하여, APCS mRNA 상대 발현량치의 중앙치를 표 3에 나타냈다. 표 3에서, N(M)은 2'-O-메틸-RNA를, N(F)는 2'-F-RNA를 나타낸다. 여기서, N은 A, C, G 또는 U를 나타낸다. 표 3은, 편의상 이하와 같이 분할하여 나타낸다.

[표 3-1]

[표 3-2]

본 출원은, 일본국에서 출원된 일본 특허 출원 2017-108502(출원일 : 2017년 5월 31일)를 기초로 하고 있고, 여기서 언급하는 것에 의해 그 내용은 본 명세서에 전부 포함된다.

본 발명에 의해, APCS의 발현 억제 활성을 갖는 핵산 및 상기 핵산을 유효 성분으로 하는 의약 조성물 등이 제공된다. 본 발명의 핵산 및 의약 조성물은, APCS의 발현을 억제하여, 아밀로이드 관련 질환의 치료제 또는 예방제로서 이용할 수 있다.

서열표 프리텍스트

서열 번호 1 APCS 2nd 스트랜드 cDNA의 전체 길이의 염기 서열을 나타낸다.

서열 번호 2∼644 센스쇄 핵산의 염기 서열을 나타낸다.

서열 번호 645∼1287 안티센스쇄 핵산의 염기 서열을 나타낸다.

서열 번호 1288∼1930 표적 APCS mRNA 서열의 염기 서열을 나타낸다.

서열 번호 1931∼1974 센스쇄 핵산의 염기 서열을 나타낸다.

서열 번호 1975∼2018 안티센스쇄 핵산의 염기 서열을 나타낸다.

SEQUENCE LISTING <110> KYOWA HAKKO KIRIN CO., LTD. <120> Nucleic Acids for inhibiting Expression of APCS <130> K1635AJP0009 <150> JP 2017-108502 <151> 2017-05-31 <160> 2018 <170> PatentIn version 3.5 <210> 1 <211> 960 <212> DNA <213> Homo sapiens <400> 1 gggcatgaat atcagacgct agggggacag ccactgtgtt gtctgctacc ctcatcctgg 60 tcactgcttc tgctataaca gccctaggcc aggaatatga acaagccgct gctttggatc 120 tctgtcctca ccagcctcct ggaagccttt gctcacacag acctcagtgg gaaggtgttt 180 gtatttccta gagaatctgt tactgatcat gtaaacttga tcacaccgct ggagaagcct 240 ctacagaact ttaccttgtg ttttcgagcc tatagtgatc tctctcgtgc ctacagcctc 300 ttctcctaca atacccaagg cagggataat gagctactag tttataaaga aagagttgga 360 gagtatagtc tatacattgg aagacacaaa gttacatcca aagttatcga aaagttcccg 420 gctccagtgc acatctgtgt gagctgggag tcctcatcag gtattgctga attttggatc 480 aatgggacac ctttggtgaa aaagggtctg cgacagggtt actttgtaga agctcagccc 540 aagattgtcc tggggcagga acaggattcc tatgggggca agtttgatag gagccagtcc 600 tttgtgggag agattgggga tttgtacatg tgggactctg tgctgccccc agaaaatatc 660 ctgtctgcct atcagggtac ccctctccct gccaatatcc tggactggca ggctctgaac 720 tatgaaatca gaggatatgt catcatcaaa cccttggtgt gggtctgagg tcttgactca 780 acgagagcac ttgaaaatga aatgactgtc taagagatct ggtcaaagca actggatact 840 agatcttaca tctgcagctc tttcttcttt gaatttccta tctgtatgtc tgcctaatta 900 aaaaaatata tattgtatta tgctacctgc aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 960 <210> 2 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 2 gcaugaauau cagacgcuag g 21 <210> 3 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 3 caugaauauc agacgcuagg g 21 <210> 4 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 4 auaucagacg cuagggggac a 21 <210> 5 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 5 cuagggggac agccacugug u 21 <210> 6 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 6 agggggacag ccacuguguu g 21 <210> 7 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 7 ggggacagcc acuguguugu c 21 <210> 8 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 8 gggacagcca cuguguuguc u 21 <210> 9 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 9 ggacagccac uguguugucu g 21 <210> 10 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 10 gacagccacu guguugucug c 21 <210> 11 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 11 gccacugugu ugucugcuac c 21 <210> 12 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 12 ccacuguguu gucugcuacc c 21 <210> 13 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 13 cacuguguug ucugcuaccc u 21 <210> 14 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 14 cuguguuguc ugcuacccuc a 21 <210> 15 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 15 uguguugucu gcuacccuca u 21 <210> 16 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 16 guguugucug cuacccucau c 21 <210> 17 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 17 uguugucugc uacccucauc c 21 <210> 18 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 18 guugucugcu acccucaucc u 21 <210> 19 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 19 gucugcuacc cucauccugg u 21 <210> 20 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 20 cugcuacccu cauccugguc a 21 <210> 21 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 21 gcuacccuca uccuggucac u 21 <210> 22 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 22 cuacccucau ccuggucacu g 21 <210> 23 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 23 uacccucauc cuggucacug c 21 <210> 24 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 24 acccucaucc uggucacugc u 21 <210> 25 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 25 cccucauccu ggucacugcu u 21 <210> 26 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 26 ccucauccug gucacugcuu c 21 <210> 27 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 27 cucauccugg ucacugcuuc u 21 <210> 28 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 28 cauccugguc acugcuucug c 21 <210> 29 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 29 auccugguca cugcuucugc u 21 <210> 30 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 30 uccuggucac ugcuucugcu a 21 <210> 31 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 31 ccuggucacu gcuucugcua u 21 <210> 32 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 32 cuggucacug cuucugcuau a 21 <210> 33 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 33 uggucacugc uucugcuaua a 21 <210> 34 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 34 ggucacugcu ucugcuauaa c 21 <210> 35 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 35 gucacugcuu cugcuauaac a 21 <210> 36 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 36 cacugcuucu gcuauaacag c 21 <210> 37 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 37 acugcuucug cuauaacagc c 21 <210> 38 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 38 cugcuucugc uauaacagcc c 21 <210> 39 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 39 gcuucugcua uaacagcccu a 21 <210> 40 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 40 cuucugcuau aacagcccua g 21 <210> 41 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 41 uucugcuaua acagcccuag g 21 <210> 42 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 42 ucugcuauaa cagcccuagg c 21 <210> 43 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 43 cugcuauaac agcccuaggc c 21 <210> 44 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 44 ugcuauaaca gcccuaggcc a 21 <210> 45 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 45 gcuauaacag cccuaggcca g 21 <210> 46 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 46 cuauaacagc ccuaggccag g 21 <210> 47 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 47 uauaacagcc cuaggccagg a 21 <210> 48 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 48 auaacagccc uaggccagga a 21 <210> 49 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 49 uaacagcccu aggccaggaa u 21 <210> 50 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 50 acagcccuag gccaggaaua u 21 <210> 51 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 51 cagcccuagg ccaggaauau g 21 <210> 52 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 52 agcccuaggc caggaauaug a 21 <210> 53 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 53 gcccuaggcc aggaauauga a 21 <210> 54 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 54 cccuaggcca ggaauaugaa c 21 <210> 55 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 55 ccuaggccag gaauaugaac a 21 <210> 56 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 56 cuaggccagg aauaugaaca a 21 <210> 57 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 57 uaggccagga auaugaacaa g 21 <210> 58 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 58 aggccaggaa uaugaacaag c 21 <210> 59 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 59 ggccaggaau augaacaagc c 21 <210> 60 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 60 gccaggaaua ugaacaagcc g 21 <210> 61 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 61 ccaggaauau gaacaagccg c 21 <210> 62 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 62 caggaauaug aacaagccgc u 21 <210> 63 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 63 aggaauauga acaagccgcu g 21 <210> 64 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 64 ggaauaugaa caagccgcug c 21 <210> 65 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 65 gaauaugaac aagccgcugc u 21 <210> 66 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 66 aauaugaaca agccgcugcu u 21 <210> 67 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 67 auaugaacaa gccgcugcuu u 21 <210> 68 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 68 uaugaacaag ccgcugcuuu g 21 <210> 69 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 69 augaacaagc cgcugcuuug g 21 <210> 70 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 70 ugaacaagcc gcugcuuugg a 21 <210> 71 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 71 gaacaagccg cugcuuugga u 21 <210> 72 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 72 aacaagccgc ugcuuuggau c 21 <210> 73 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 73 acaagccgcu gcuuuggauc u 21 <210> 74 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 74 caagccgcug cuuuggaucu c 21 <210> 75 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 75 aagccgcugc uuuggaucuc u 21 <210> 76 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 76 agccgcugcu uuggaucucu g 21 <210> 77 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 77 gccgcugcuu uggaucucug u 21 <210> 78 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 78 ccgcugcuuu ggaucucugu c 21 <210> 79 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 79 cgcugcuuug gaucucuguc c 21 <210> 80 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 80 gcugcuuugg aucucugucc u 21 <210> 81 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 81 cugcuuugga ucucuguccu c 21 <210> 82 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 82 ugcuuuggau cucuguccuc a 21 <210> 83 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 83 gcuuuggauc ucuguccuca c 21 <210> 84 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 84 cuuuggaucu cuguccucac c 21 <210> 85 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 85 uuuggaucuc uguccucacc a 21 <210> 86 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 86 ggaucucugu ccucaccagc c 21 <210> 87 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 87 gaucucuguc cucaccagcc u 21 <210> 88 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 88 cucuguccuc accagccucc u 21 <210> 89 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 89 cuguccucac cagccuccug g 21 <210> 90 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 90 uguccucacc agccuccugg a 21 <210> 91 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 91 guccucacca gccuccugga a 21 <210> 92 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 92 uccucaccag ccuccuggaa g 21 <210> 93 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 93 cucaccagcc uccuggaagc c 21 <210> 94 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 94 ucaccagccu ccuggaagcc u 21 <210> 95 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 95 accagccucc uggaagccuu u 21 <210> 96 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 96 ccagccuccu ggaagccuuu g 21 <210> 97 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 97 cagccuccug gaagccuuug c 21 <210> 98 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 98 agccuccugg aagccuuugc u 21 <210> 99 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 99 gccuccugga agccuuugcu c 21 <210> 100 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 100 ccuccuggaa gccuuugcuc a 21 <210> 101 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 101 cuccuggaag ccuuugcuca c 21 <210> 102 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 102 uccuggaagc cuuugcucac a 21 <210> 103 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 103 ccuggaagcc uuugcucaca c 21 <210> 104 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 104 cuggaagccu uugcucacac a 21 <210> 105 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 105 ggaagccuuu gcucacacag a 21 <210> 106 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 106 gaagccuuug cucacacaga c 21 <210> 107 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 107 aagccuuugc ucacacagac c 21 <210> 108 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 108 agccuuugcu cacacagacc u 21 <210> 109 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 109 gccuuugcuc acacagaccu c 21 <210> 110 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 110 ccuuugcuca cacagaccuc a 21 <210> 111 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 111 cuuugcucac acagaccuca g 21 <210> 112 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 112 uuugcucaca cagaccucag u 21 <210> 113 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 113 ugcucacaca gaccucagug g 21 <210> 114 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 114 cucacacaga ccucaguggg a 21 <210> 115 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 115 cacacagacc ucagugggaa g 21 <210> 116 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 116 acacagaccu cagugggaag g 21 <210> 117 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 117 cacagaccuc agugggaagg u 21 <210> 118 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 118 agaccucagu gggaaggugu u 21 <210> 119 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 119 gaccucagug ggaagguguu u 21 <210> 120 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 120 accucagugg gaagguguuu g 21 <210> 121 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 121 ccucaguggg aagguguuug u 21 <210> 122 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 122 cucaguggga agguguuugu a 21 <210> 123 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 123 ucagugggaa gguguuugua u 21 <210> 124 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 124 cagugggaag guguuuguau u 21 <210> 125 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 125 agugggaagg uguuuguauu u 21 <210> 126 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 126 gugggaaggu guuuguauuu c 21 <210> 127 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 127 ugggaaggug uuuguauuuc c 21 <210> 128 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 128 gggaaggugu uuguauuucc u 21 <210> 129 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 129 ggaagguguu uguauuuccu a 21 <210> 130 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 130 gaagguguuu guauuuccua g 21 <210> 131 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 131 aagguguuug uauuuccuag a 21 <210> 132 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 132 agguguuugu auuuccuaga g 21 <210> 133 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 133 gguguuugua uuuccuagag a 21 <210> 134 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 134 guguuuguau uuccuagaga a 21 <210> 135 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 135 uguuuguauu uccuagagaa u 21 <210> 136 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 136 guuuguauuu ccuagagaau c 21 <210> 137 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 137 uuuguauuuc cuagagaauc u 21 <210> 138 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 138 uuguauuucc uagagaaucu g 21 <210> 139 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 139 uguauuuccu agagaaucug u 21 <210> 140 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 140 guauuuccua gagaaucugu u 21 <210> 141 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 141 uauuuccuag agaaucuguu a 21 <210> 142 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 142 auuuccuaga gaaucuguua c 21 <210> 143 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 143 uuuccuagag aaucuguuac u 21 <210> 144 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 144 uccuagagaa ucuguuacug a 21 <210> 145 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 145 ccuagagaau cuguuacuga u 21 <210> 146 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 146 cuagagaauc uguuacugau c 21 <210> 147 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 147 uagagaaucu guuacugauc a 21 <210> 148 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 148 agagaaucug uuacugauca u 21 <210> 149 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 149 gagaaucugu uacugaucau g 21 <210> 150 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 150 agaaucuguu acugaucaug u 21 <210> 151 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 151 gaaucuguua cugaucaugu a 21 <210> 152 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 152 aaucuguuac ugaucaugua a 21 <210> 153 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 153 aucuguuacu gaucauguaa a 21 <210> 154 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 154 ucuguuacug aucauguaaa c 21 <210> 155 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 155 cuguuacuga ucauguaaac u 21 <210> 156 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 156 uguuacugau cauguaaacu u 21 <210> 157 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 157 guuacugauc auguaaacuu g 21 <210> 158 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 158 acugaucaug uaaacuugau c 21 <210> 159 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 159 cugaucaugu aaacuugauc a 21 <210> 160 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 160 ugaucaugua aacuugauca c 21 <210> 161 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 161 gaucauguaa acuugaucac a 21 <210> 162 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 162 ucauguaaac uugaucacac c 21 <210> 163 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 163 cauguaaacu ugaucacacc g 21 <210> 164 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 164 uaaacuugau cacaccgcug g 21 <210> 165 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 165 aaacuugauc acaccgcugg a 21 <210> 166 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 166 acuugaucac accgcuggag a 21 <210> 167 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 167 uugaucacac cgcuggagaa g 21 <210> 168 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 168 ugaucacacc gcuggagaag c 21 <210> 169 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 169 gaucacaccg cuggagaagc c 21 <210> 170 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 170 cacaccgcug gagaagccuc u 21 <210> 171 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 171 acaccgcugg agaagccucu a 21 <210> 172 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 172 caccgcugga gaagccucua c 21 <210> 173 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 173 accgcuggag aagccucuac a 21 <210> 174 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 174 ccgcuggaga agccucuaca g 21 <210> 175 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 175 cgcuggagaa gccucuacag a 21 <210> 176 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 176 gcuggagaag ccucuacaga a 21 <210> 177 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 177 cuggagaagc cucuacagaa c 21 <210> 178 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 178 uggagaagcc ucuacagaac u 21 <210> 179 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 179 ggagaagccu cuacagaacu u 21 <210> 180 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 180 gagaagccuc uacagaacuu u 21 <210> 181 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 181 agaagccucu acagaacuuu a 21 <210> 182 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 182 gaagccucua cagaacuuua c 21 <210> 183 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 183 aagccucuac agaacuuuac c 21 <210> 184 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 184 agccucuaca gaacuuuacc u 21 <210> 185 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 185 gccucuacag aacuuuaccu u 21 <210> 186 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 186 ccucuacaga acuuuaccuu g 21 <210> 187 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 187 cucuacagaa cuuuaccuug u 21 <210> 188 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 188 ucuacagaac uuuaccuugu g 21 <210> 189 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 189 cuacagaacu uuaccuugug u 21 <210> 190 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 190 uacagaacuu uaccuugugu u 21 <210> 191 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 191 acagaacuuu accuuguguu u 21 <210> 192 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 192 cagaacuuua ccuuguguuu u 21 <210> 193 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 193 agaacuuuac cuuguguuuu c 21 <210> 194 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 194 gaacuuuacc uuguguuuuc g 21 <210> 195 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 195 aacuuuaccu uguguuuucg a 21 <210> 196 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 196 cuuuaccuug uguuuucgag c 21 <210> 197 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 197 accuuguguu uucgagccua u 21 <210> 198 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 198 ccuuguguuu ucgagccuau a 21 <210> 199 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 199 cuuguguuuu cgagccuaua g 21 <210> 200 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 200 uuguguuuuc gagccuauag u 21 <210> 201 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 201 guguuuucga gccuauagug a 21 <210> 202 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 202 guuuucgagc cuauagugau c 21 <210> 203 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 203 uuuucgagcc uauagugauc u 21 <210> 204 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 204 cgagccuaua gugaucucuc u 21 <210> 205 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 205 gagccuauag ugaucucucu c 21 <210> 206 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 206 agccuauagu gaucucucuc g 21 <210> 207 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 207 gccuauagug aucucucucg u 21 <210> 208 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 208 ccuauaguga ucucucucgu g 21 <210> 209 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 209 cuauagugau cucucucgug c 21 <210> 210 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 210 uauagugauc ucucucgugc c 21 <210> 211 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 211 agugaucucu cucgugccua c 21 <210> 212 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 212 gugaucucuc ucgugccuac a 21 <210> 213 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 213 ugaucucucu cgugccuaca g 21 <210> 214 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 214 gaucucucuc gugccuacag c 21 <210> 215 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 215 cucucgugcc uacagccucu u 21 <210> 216 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 216 ucucgugccu acagccucuu c 21 <210> 217 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 217 cucgugccua cagccucuuc u 21 <210> 218 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 218 cgugccuaca gccucuucuc c 21 <210> 219 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 219 gugccuacag ccucuucucc u 21 <210> 220 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 220 gccuacagcc ucuucuccua c 21 <210> 221 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 221 ccuacagccu cuucuccuac a 21 <210> 222 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 222 cuacagccuc uucuccuaca a 21 <210> 223 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 223 uacagccucu ucuccuacaa u 21 <210> 224 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 224 acagccucuu cuccuacaau a 21 <210> 225 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 225 cagccucuuc uccuacaaua c 21 <210> 226 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 226 agccucuucu ccuacaauac c 21 <210> 227 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 227 gccucuucuc cuacaauacc c 21 <210> 228 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 228 ccucuucucc uacaauaccc a 21 <210> 229 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 229 ucuucuccua caauacccaa g 21 <210> 230 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 230 ucuccuacaa uacccaaggc a 21 <210> 231 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 231 cuccuacaau acccaaggca g 21 <210> 232 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 232 uccuacaaua cccaaggcag g 21 <210> 233 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 233 ccuacaauac ccaaggcagg g 21 <210> 234 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 234 cuacaauacc caaggcaggg a 21 <210> 235 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 235 caauacccaa ggcagggaua a 21 <210> 236 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 236 auacccaagg cagggauaau g 21 <210> 237 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 237 uacccaaggc agggauaaug a 21 <210> 238 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 238 ccaaggcagg gauaaugagc u 21 <210> 239 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 239 aaggcaggga uaaugagcua c 21 <210> 240 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 240 aggcagggau aaugagcuac u 21 <210> 241 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 241 gcagggauaa ugagcuacua g 21 <210> 242 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 242 cagggauaau gagcuacuag u 21 <210> 243 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 243 agggauaaug agcuacuagu u 21 <210> 244 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 244 gggauaauga gcuacuaguu u 21 <210> 245 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 245 ggauaaugag cuacuaguuu a 21 <210> 246 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 246 gauaaugagc uacuaguuua u 21 <210> 247 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 247 auaaugagcu acuaguuuau a 21 <210> 248 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 248 uaaugagcua cuaguuuaua a 21 <210> 249 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 249 augagcuacu aguuuauaaa g 21 <210> 250 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 250 ugagcuacua guuuauaaag a 21 <210> 251 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 251 gagcuacuag uuuauaaaga a 21 <210> 252 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 252 agcuacuagu uuauaaagaa a 21 <210> 253 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 253 gcuacuaguu uauaaagaaa g 21 <210> 254 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 254 cuacuaguuu auaaagaaag a 21 <210> 255 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 255 aguuuauaaa gaaagaguug g 21 <210> 256 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 256 aagaaagagu uggagaguau a 21 <210> 257 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 257 agaaagaguu ggagaguaua g 21 <210> 258 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 258 gaaagaguug gagaguauag u 21 <210> 259 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 259 aagaguugga gaguauaguc u 21 <210> 260 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 260 agaguuggag aguauagucu a 21 <210> 261 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 261 gaguuggaga guauagucua u 21 <210> 262 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 262 aguuggagag uauagucuau a 21 <210> 263 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 263 guuggagagu auagucuaua c 21 <210> 264 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 264 uuggagagua uagucuauac a 21 <210> 265 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 265 uggagaguau agucuauaca u 21 <210> 266 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 266 ggagaguaua gucuauacau u 21 <210> 267 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 267 gagaguauag ucuauacauu g 21 <210> 268 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 268 agaguauagu cuauacauug g 21 <210> 269 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 269 gaguauaguc uauacauugg a 21 <210> 270 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 270 aguauagucu auacauugga a 21 <210> 271 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 271 guauagucua uacauuggaa g 21 <210> 272 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 272 gucuauacau uggaagacac a 21 <210> 273 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 273 cuauacauug gaagacacaa a 21 <210> 274 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 274 uauacauugg aagacacaaa g 21 <210> 275 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 275 auacauugga agacacaaag u 21 <210> 276 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 276 acauuggaag acacaaaguu a 21 <210> 277 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 277 cauuggaaga cacaaaguua c 21 <210> 278 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 278 auuggaagac acaaaguuac a 21 <210> 279 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 279 uggaagacac aaaguuacau c 21 <210> 280 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 280 ggaagacaca aaguuacauc c 21 <210> 281 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 281 gaagacacaa aguuacaucc a 21 <210> 282 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 282 aagacacaaa guuacaucca a 21 <210> 283 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 283 agacacaaag uuacauccaa a 21 <210> 284 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 284 gacacaaagu uacauccaaa g 21 <210> 285 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 285 acacaaaguu acauccaaag u 21 <210> 286 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 286 cacaaaguua cauccaaagu u 21 <210> 287 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 287 caaaguuaca uccaaaguua u 21 <210> 288 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 288 aaaguuacau ccaaaguuau c 21 <210> 289 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 289 aaguuacauc caaaguuauc g 21 <210> 290 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 290 aguuacaucc aaaguuaucg a 21 <210> 291 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 291 guuacaucca aaguuaucga a 21 <210> 292 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 292 uuacauccaa aguuaucgaa a 21 <210> 293 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 293 uacauccaaa guuaucgaaa a 21 <210> 294 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 294 acauccaaag uuaucgaaaa g 21 <210> 295 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 295 cauccaaagu uaucgaaaag u 21 <210> 296 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 296 auccaaaguu aucgaaaagu u 21 <210> 297 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 297 uccaaaguua ucgaaaaguu c 21 <210> 298 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 298 ccaaaguuau cgaaaaguuc c 21 <210> 299 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 299 caaaguuauc gaaaaguucc c 21 <210> 300 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 300 cgaaaaguuc ccggcuccag u 21 <210> 301 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 301 aaaaguuccc ggcuccagug c 21 <210> 302 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 302 cccggcucca gugcacaucu g 21 <210> 303 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 303 cggcuccagu gcacaucugu g 21 <210> 304 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 304 ggcuccagug cacaucugug u 21 <210> 305 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 305 gcuccagugc acaucugugu g 21 <210> 306 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 306 cuccagugca caucugugug a 21 <210> 307 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 307 ccagugcaca ucugugugag c 21 <210> 308 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 308 gugcacaucu gugugagcug g 21 <210> 309 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 309 gcacaucugu gugagcuggg a 21 <210> 310 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 310 acaucugugu gagcugggag u 21 <210> 311 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 311 aucuguguga gcugggaguc c 21 <210> 312 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 312 ugugugagcu gggaguccuc a 21 <210> 313 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 313 gugugagcug ggaguccuca u 21 <210> 314 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 314 agcugggagu ccucaucagg u 21 <210> 315 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 315 gcugggaguc cucaucaggu a 21 <210> 316 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 316 cugggagucc ucaucaggua u 21 <210> 317 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 317 ugggaguccu caucagguau u 21 <210> 318 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 318 gggaguccuc aucagguauu g 21 <210> 319 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 319 ggaguccuca ucagguauug c 21 <210> 320 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 320 gaguccucau cagguauugc u 21 <210> 321 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 321 guccucauca gguauugcug a 21 <210> 322 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 322 uccucaucag guauugcuga a 21 <210> 323 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 323 ccucaucagg uauugcugaa u 21 <210> 324 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 324 cucaucaggu auugcugaau u 21 <210> 325 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 325 ucaucaggua uugcugaauu u 21 <210> 326 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 326 caucagguau ugcugaauuu u 21 <210> 327 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 327 aucagguauu gcugaauuuu g 21 <210> 328 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 328 ucagguauug cugaauuuug g 21 <210> 329 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 329 cagguauugc ugaauuuugg a 21 <210> 330 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 330 agguauugcu gaauuuugga u 21 <210> 331 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 331 gguauugcug aauuuuggau c 21 <210> 332 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 332 guauugcuga auuuuggauc a 21 <210> 333 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 333 auugcugaau uuuggaucaa u 21 <210> 334 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 334 ugcugaauuu uggaucaaug g 21 <210> 335 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 335 gcugaauuuu ggaucaaugg g 21 <210> 336 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 336 cugaauuuug gaucaauggg a 21 <210> 337 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 337 gaauuuugga ucaaugggac a 21 <210> 338 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 338 ggaucaaugg gacaccuuug g 21 <210> 339 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 339 caaugggaca ccuuugguga a 21 <210> 340 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 340 aaugggacac cuuuggugaa a 21 <210> 341 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 341 augggacacc uuuggugaaa a 21 <210> 342 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 342 ugggacaccu uuggugaaaa a 21 <210> 343 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 343 gggacaccuu uggugaaaaa g 21 <210> 344 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 344 ggacaccuuu ggugaaaaag g 21 <210> 345 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 345 accuuuggug aaaaaggguc u 21 <210> 346 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 346 ccuuugguga aaaagggucu g 21 <210> 347 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 347 cuuuggugaa aaagggucug c 21 <210> 348 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 348 ggugaaaaag ggucugcgac a 21 <210> 349 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 349 gugaaaaagg gucugcgaca g 21 <210> 350 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 350 ugaaaaaggg ucugcgacag g 21 <210> 351 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 351 gaaaaagggu cugcgacagg g 21 <210> 352 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 352 aaagggucug cgacaggguu a 21 <210> 353 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 353 aagggucugc gacaggguua c 21 <210> 354 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 354 agggucugcg acaggguuac u 21 <210> 355 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 355 gggucugcga caggguuacu u 21 <210> 356 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 356 ggucugcgac aggguuacuu u 21 <210> 357 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 357 gucugcgaca ggguuacuuu g 21 <210> 358 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 358 ucugcgacag gguuacuuug u 21 <210> 359 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 359 cugcgacagg guuacuuugu a 21 <210> 360 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 360 ugcgacaggg uuacuuugua g 21 <210> 361 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 361 gcgacagggu uacuuuguag a 21 <210> 362 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 362 cgacaggguu acuuuguaga a 21 <210> 363 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 363 gacaggguua cuuuguagaa g 21 <210> 364 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 364 acaggguuac uuuguagaag c 21 <210> 365 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 365 caggguuacu uuguagaagc u 21 <210> 366 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 366 aggguuacuu uguagaagcu c 21 <210> 367 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 367 ggguuacuuu guagaagcuc a 21 <210> 368 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 368 gguuacuuug uagaagcuca g 21 <210> 369 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 369 guuacuuugu agaagcucag c 21 <210> 370 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 370 agaagcucag cccaagauug u 21 <210> 371 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 371 gaagcucagc ccaagauugu c 21 <210> 372 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 372 aagcucagcc caagauuguc c 21 <210> 373 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 373 agcucagccc aagauugucc u 21 <210> 374 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 374 cucagcccaa gauuguccug g 21 <210> 375 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 375 agcccaagau uguccugggg c 21 <210> 376 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 376 ccaagauugu ccuggggcag g 21 <210> 377 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 377 caagauuguc cuggggcagg a 21 <210> 378 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 378 agauuguccu ggggcaggaa c 21 <210> 379 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 379 gauuguccug gggcaggaac a 21 <210> 380 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 380 uuguccuggg gcaggaacag g 21 <210> 381 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 381 uccuggggca ggaacaggau u 21 <210> 382 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 382 cuggggcagg aacaggauuc c 21 <210> 383 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 383 uggggcagga acaggauucc u 21 <210> 384 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 384 ggggcaggaa caggauuccu a 21 <210> 385 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 385 ggcaggaaca ggauuccuau g 21 <210> 386 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 386 gcaggaacag gauuccuaug g 21 <210> 387 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 387 caggaacagg auuccuaugg g 21 <210> 388 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 388 ggaacaggau uccuaugggg g 21 <210> 389 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 389 gaacaggauu ccuauggggg c 21 <210> 390 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 390 acaggauucc uaugggggca a 21 <210> 391 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 391 caggauuccu augggggcaa g 21 <210> 392 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 392 ggauuccuau gggggcaagu u 21 <210> 393 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 393 gauuccuaug ggggcaaguu u 21 <210> 394 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 394 auuccuaugg gggcaaguuu g 21 <210> 395 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 395 uuccuauggg ggcaaguuug a 21 <210> 396 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 396 uccuaugggg gcaaguuuga u 21 <210> 397 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 397 ccuauggggg caaguuugau a 21 <210> 398 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 398 cuaugggggc aaguuugaua g 21 <210> 399 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 399 uaugggggca aguuugauag g 21 <210> 400 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 400 gggggcaagu uugauaggag c 21 <210> 401 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 401 ggggcaaguu ugauaggagc c 21 <210> 402 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 402 gggcaaguuu gauaggagcc a 21 <210> 403 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 403 ggcaaguuug auaggagcca g 21 <210> 404 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 404 gcaaguuuga uaggagccag u 21 <210> 405 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 405 caaguuugau aggagccagu c 21 <210> 406 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 406 aaguuugaua ggagccaguc c 21 <210> 407 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 407 uugauaggag ccaguccuuu g 21 <210> 408 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 408 ugauaggagc caguccuuug u 21 <210> 409 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 409 gauaggagcc aguccuuugu g 21 <210> 410 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 410 auaggagcca guccuuugug g 21 <210> 411 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 411 aggagccagu ccuuuguggg a 21 <210> 412 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 412 ggagccaguc cuuuguggga g 21 <210> 413 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 413 gagccagucc uuugugggag a 21 <210> 414 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 414 agccaguccu uugugggaga g 21 <210> 415 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 415 gccaguccuu ugugggagag a 21 <210> 416 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 416 ccaguccuuu gugggagaga u 21 <210> 417 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 417 caguccuuug ugggagagau u 21 <210> 418 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 418 aguccuuugu gggagagauu g 21 <210> 419 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 419 guccuuugug ggagagauug g 21 <210> 420 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 420 uccuuugugg gagagauugg g 21 <210> 421 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 421 ccuuuguggg agagauuggg g 21 <210> 422 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 422 cuuuguggga gagauugggg a 21 <210> 423 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 423 uugugggaga gauuggggau u 21 <210> 424 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 424 ugugggagag auuggggauu u 21 <210> 425 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 425 gugggagaga uuggggauuu g 21 <210> 426 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 426 ugggagagau uggggauuug u 21 <210> 427 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 427 gggagagauu ggggauuugu a 21 <210> 428 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 428 ggagagauug gggauuugua c 21 <210> 429 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 429 gagagauugg ggauuuguac a 21 <210> 430 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 430 agagauuggg gauuuguaca u 21 <210> 431 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 431 gagauugggg auuuguacau g 21 <210> 432 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 432 agauugggga uuuguacaug u 21 <210> 433 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 433 ggggauuugu acauguggga c 21 <210> 434 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 434 gggauuugua caugugggac u 21 <210> 435 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 435 ggauuuguac augugggacu c 21 <210> 436 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 436 gauuuguaca ugugggacuc u 21 <210> 437 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 437 uguacaugug ggacucugug c 21 <210> 438 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 438 guacaugugg gacucugugc u 21 <210> 439 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 439 acauguggga cucugugcug c 21 <210> 440 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 440 gggacucugu gcugccccca g 21 <210> 441 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 441 ggacucugug cugcccccag a 21 <210> 442 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 442 acucugugcu gcccccagaa a 21 <210> 443 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 443 cucugugcug cccccagaaa a 21 <210> 444 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 444 cugugcugcc cccagaaaau a 21 <210> 445 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 445 ugugcugccc ccagaaaaua u 21 <210> 446 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 446 gugcugcccc cagaaaauau c 21 <210> 447 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 447 gcugccccca gaaaauaucc u 21 <210> 448 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 448 cccccagaaa auauccuguc u 21 <210> 449 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 449 cccagaaaau auccugucug c 21 <210> 450 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 450 ccagaaaaua uccugucugc c 21 <210> 451 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 451 cagaaaauau ccugucugcc u 21 <210> 452 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 452 gaaaauaucc ugucugccua u 21 <210> 453 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 453 aaaauauccu gucugccuau c 21 <210> 454 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 454 aaauauccug ucugccuauc a 21 <210> 455 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 455 ccugucugcc uaucagggua c 21 <210> 456 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 456 cugucugccu aucaggguac c 21 <210> 457 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 457 gucugccuau caggguaccc c 21 <210> 458 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 458 ugccuaucag gguaccccuc u 21 <210> 459 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 459 gccuaucagg guaccccucu c 21 <210> 460 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 460 ccuaucaggg uaccccucuc c 21 <210> 461 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 461 cuaucagggu accccucucc c 21 <210> 462 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 462 caggguaccc cucucccugc c 21 <210> 463 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 463 ggguaccccu cucccugcca a 21 <210> 464 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 464 gguaccccuc ucccugccaa u 21 <210> 465 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 465 guaccccucu cccugccaau a 21 <210> 466 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 466 uaccccucuc ccugccaaua u 21 <210> 467 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 467 ccccucuccc ugccaauauc c 21 <210> 468 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 468 cccucucccu gccaauaucc u 21 <210> 469 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 469 cugccaauau ccuggacugg c 21 <210> 470 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 470 ccaauauccu ggacuggcag g 21 <210> 471 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 471 caauauccug gacuggcagg c 21 <210> 472 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 472 uccuggacug gcaggcucug a 21 <210> 473 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 473 ccuggacugg caggcucuga a 21 <210> 474 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 474 cuggacuggc aggcucugaa c 21 <210> 475 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 475 uggacuggca ggcucugaac u 21 <210> 476 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 476 ggacuggcag gcucugaacu a 21 <210> 477 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 477 gacuggcagg cucugaacua u 21 <210> 478 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 478 acuggcaggc ucugaacuau g 21 <210> 479 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 479 cuggcaggcu cugaacuaug a 21 <210> 480 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 480 uggcaggcuc ugaacuauga a 21 <210> 481 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 481 ggcaggcucu gaacuaugaa a 21 <210> 482 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 482 gcaggcucug aacuaugaaa u 21 <210> 483 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 483 caggcucuga acuaugaaau c 21 <210> 484 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 484 aggcucugaa cuaugaaauc a 21 <210> 485 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 485 ggcucugaac uaugaaauca g 21 <210> 486 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 486 gcucugaacu augaaaucag a 21 <210> 487 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 487 cucugaacua ugaaaucaga g 21 <210> 488 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 488 ucugaacuau gaaaucagag g 21 <210> 489 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 489 gaacuaugaa aucagaggau a 21 <210> 490 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 490 aacuaugaaa ucagaggaua u 21 <210> 491 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 491 acuaugaaau cagaggauau g 21 <210> 492 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 492 cuaugaaauc agaggauaug u 21 <210> 493 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 493 uaugaaauca gaggauaugu c 21 <210> 494 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 494 ugaaaucaga ggauauguca u 21 <210> 495 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 495 gaaaucagag gauaugucau c 21 <210> 496 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 496 aaaucagagg auaugucauc a 21 <210> 497 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 497 aaucagagga uaugucauca u 21 <210> 498 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 498 cagaggauau gucaucauca a 21 <210> 499 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 499 agaggauaug ucaucaucaa a 21 <210> 500 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 500 gaggauaugu caucaucaaa c 21 <210> 501 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 501 aggauauguc aucaucaaac c 21 <210> 502 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 502 ggauauguca ucaucaaacc c 21 <210> 503 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 503 gauaugucau caucaaaccc u 21 <210> 504 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 504 augucaucau caaacccuug g 21 <210> 505 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 505 caucaucaaa cccuuggugu g 21 <210> 506 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 506 ucaucaaacc cuuggugugg g 21 <210> 507 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 507 acccuuggug ugggucugag g 21 <210> 508 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 508 cccuuggugu gggucugagg u 21 <210> 509 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 509 ccuuggugug ggucugaggu c 21 <210> 510 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 510 cuuggugugg gucugagguc u 21 <210> 511 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 511 uggugugggu cugaggucuu g 21 <210> 512 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 512 gguguggguc ugaggucuug a 21 <210> 513 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 513 gugugggucu gaggucuuga c 21 <210> 514 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 514 ugugggucug aggucuugac u 21 <210> 515 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 515 gugggucuga ggucuugacu c 21 <210> 516 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 516 gggucugagg ucuugacuca a 21 <210> 517 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 517 ggucugaggu cuugacucaa c 21 <210> 518 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 518 gucugagguc uugacucaac g 21 <210> 519 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 519 cugaggucuu gacucaacga g 21 <210> 520 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 520 ugaggucuug acucaacgag a 21 <210> 521 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 521 gaggucuuga cucaacgaga g 21 <210> 522 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 522 aggucuugac ucaacgagag c 21 <210> 523 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 523 ggucuugacu caacgagagc a 21 <210> 524 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 524 gucuugacuc aacgagagca c 21 <210> 525 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 525 ucuugacuca acgagagcac u 21 <210> 526 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 526 cuugacucaa cgagagcacu u 21 <210> 527 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 527 uugacucaac gagagcacuu g 21 <210> 528 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 528 ugacucaacg agagcacuug a 21 <210> 529 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 529 gacucaacga gagcacuuga a 21 <210> 530 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 530 acucaacgag agcacuugaa a 21 <210> 531 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 531 cucaacgaga gcacuugaaa a 21 <210> 532 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 532 ucaacgagag cacuugaaaa u 21 <210> 533 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 533 caacgagagc acuugaaaau g 21 <210> 534 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 534 aacgagagca cuugaaaaug a 21 <210> 535 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 535 acgagagcac uugaaaauga a 21 <210> 536 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 536 cgagagcacu ugaaaaugaa a 21 <210> 537 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 537 gagagcacuu gaaaaugaaa u 21 <210> 538 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 538 agagcacuug aaaaugaaau g 21 <210> 539 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 539 gagcacuuga aaaugaaaug a 21 <210> 540 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 540 agcacuugaa aaugaaauga c 21 <210> 541 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 541 gcacuugaaa augaaaugac u 21 <210> 542 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 542 cacuugaaaa ugaaaugacu g 21 <210> 543 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 543 acuugaaaau gaaaugacug u 21 <210> 544 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 544 cuugaaaaug aaaugacugu c 21 <210> 545 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 545 uugaaaauga aaugacuguc u 21 <210> 546 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 546 ugaaaaugaa augacugucu a 21 <210> 547 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 547 gaaaaugaaa ugacugucua a 21 <210> 548 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 548 aaaaugaaau gacugucuaa g 21 <210> 549 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 549 aaaugaaaug acugucuaag a 21 <210> 550 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 550 aaugaaauga cugucuaaga g 21 <210> 551 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 551 augaaaugac ugucuaagag a 21 <210> 552 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 552 ugaaaugacu gucuaagaga u 21 <210> 553 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 553 gaaaugacug ucuaagagau c 21 <210> 554 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 554 aaaugacugu cuaagagauc u 21 <210> 555 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 555 augacugucu aagagaucug g 21 <210> 556 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 556 ugacugucua agagaucugg u 21 <210> 557 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 557 gacugucuaa gagaucuggu c 21 <210> 558 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 558 acugucuaag agaucugguc a 21 <210> 559 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 559 cugucuaaga gaucugguca a 21 <210> 560 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 560 ugucuaagag aucuggucaa a 21 <210> 561 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 561 gucuaagaga ucuggucaaa g 21 <210> 562 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 562 ucuaagagau cuggucaaag c 21 <210> 563 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 563 cuaagagauc uggucaaagc a 21 <210> 564 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 564 uaagagaucu ggucaaagca a 21 <210> 565 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 565 aagagaucug gucaaagcaa c 21 <210> 566 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 566 agagaucugg ucaaagcaac u 21 <210> 567 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 567 gagaucuggu caaagcaacu g 21 <210> 568 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 568 agaucugguc aaagcaacug g 21 <210> 569 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 569 gaucugguca aagcaacugg a 21 <210> 570 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 570 aucuggucaa agcaacugga u 21 <210> 571 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 571 ucuggucaaa gcaacuggau a 21 <210> 572 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 572 cuggucaaag caacuggaua c 21 <210> 573 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 573 uggucaaagc aacuggauac u 21 <210> 574 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 574 ggucaaagca acuggauacu a 21 <210> 575 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 575 gucaaagcaa cuggauacua g 21 <210> 576 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 576 ucaaagcaac uggauacuag a 21 <210> 577 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 577 caaagcaacu ggauacuaga u 21 <210> 578 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 578 aaagcaacug gauacuagau c 21 <210> 579 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 579 aagcaacugg auacuagauc u 21 <210> 580 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 580 agcaacugga uacuagaucu u 21 <210> 581 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 581 gcaacuggau acuagaucuu a 21 <210> 582 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 582 caacuggaua cuagaucuua c 21 <210> 583 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 583 aacuggauac uagaucuuac a 21 <210> 584 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 584 acuggauacu agaucuuaca u 21 <210> 585 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 585 cuggauacua gaucuuacau c 21 <210> 586 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 586 uggauacuag aucuuacauc u 21 <210> 587 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 587 ggauacuaga ucuuacaucu g 21 <210> 588 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 588 gauacuagau cuuacaucug c 21 <210> 589 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 589 auacuagauc uuacaucugc a 21 <210> 590 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 590 acuagaucuu acaucugcag c 21 <210> 591 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 591 cuagaucuua caucugcagc u 21 <210> 592 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 592 agaucuuaca ucugcagcuc u 21 <210> 593 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 593 gaucuuacau cugcagcucu u 21 <210> 594 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 594 aucuuacauc ugcagcucuu u 21 <210> 595 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 595 ucuuacaucu gcagcucuuu c 21 <210> 596 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 596 cuuacaucug cagcucuuuc u 21 <210> 597 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 597 uuacaucugc agcucuuucu u 21 <210> 598 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 598 uacaucugca gcucuuucuu c 21 <210> 599 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 599 acaucugcag cucuuucuuc u 21 <210> 600 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 600 caucugcagc ucuuucuucu u 21 <210> 601 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 601 aucugcagcu cuuucuucuu u 21 <210> 602 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 602 ucugcagcuc uuucuucuuu g 21 <210> 603 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 603 cugcagcucu uucuucuuug a 21 <210> 604 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 604 ugcagcucuu ucuucuuuga a 21 <210> 605 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 605 gcagcucuuu cuucuuugaa u 21 <210> 606 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 606 cagcucuuuc uucuuugaau u 21 <210> 607 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 607 agcucuuucu ucuuugaauu u 21 <210> 608 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 608 gcucuuucuu cuuugaauuu c 21 <210> 609 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 609 cucuuucuuc uuugaauuuc c 21 <210> 610 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 610 ucuuucuucu uugaauuucc u 21 <210> 611 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 611 cuuucuucuu ugaauuuccu a 21 <210> 612 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 612 uuucuucuuu gaauuuccua u 21 <210> 613 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 613 uucuucuuug aauuuccuau c 21 <210> 614 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 614 ucuucuuuga auuuccuauc u 21 <210> 615 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 615 uucuuugaau uuccuaucug u 21 <210> 616 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 616 ucuuugaauu uccuaucugu a 21 <210> 617 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 617 cuuugaauuu ccuaucugua u 21 <210> 618 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 618 uuugaauuuc cuaucuguau g 21 <210> 619 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 619 uugaauuucc uaucuguaug u 21 <210> 620 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 620 ugaauuuccu aucuguaugu c 21 <210> 621 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 621 gaauuuccua ucuguauguc u 21 <210> 622 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 622 auuuccuauc uguaugucug c 21 <210> 623 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 623 uuuccuaucu guaugucugc c 21 <210> 624 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 624 uuccuaucug uaugucugcc u 21 <210> 625 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 625 uccuaucugu augucugccu a 21 <210> 626 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 626 ccuaucugua ugucugccua a 21 <210> 627 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 627 cuaucuguau gucugccuaa u 21 <210> 628 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 628 uaucuguaug ucugccuaau u 21 <210> 629 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 629 aucuguaugu cugccuaauu a 21 <210> 630 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 630 ucuguauguc ugccuaauua a 21 <210> 631 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 631 cuguaugucu gccuaauuaa a 21 <210> 632 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 632 uguaugucug ccuaauuaaa a 21 <210> 633 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 633 guaugucugc cuaauuaaaa a 21 <210> 634 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 634 uaugucugcc uaauuaaaaa a 21 <210> 635 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 635 augucugccu aauuaaaaaa a 21 <210> 636 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 636 ugucugccua auuaaaaaaa u 21 <210> 637 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 637 gucugccuaa uuaaaaaaau a 21 <210> 638 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 638 ucugccuaau uaaaaaaaua u 21 <210> 639 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 639 cugccuaauu aaaaaaauau a 21 <210> 640 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 640 ugccuaauua aaaaaauaua u 21 <210> 641 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 641 gccuaauuaa aaaaauauau a 21 <210> 642 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 642 ccuaauuaaa aaaauauaua u 21 <210> 643 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 643 cuaauuaaaa aaauauauau u 21 <210> 644 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <400> 644 uaaaaaaaua uauauuguau u 21 <210> 645 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 645 uagcgucuga uauucaugcc c 21 <210> 646 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 646 cuagcgucug auauucaugc c 21 <210> 647 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 647 ucccccuagc gucugauauu c 21 <210> 648 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 648 acaguggcug ucccccuagc g 21 <210> 649 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 649 acacaguggc ugucccccua g 21 <210> 650 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 650 caacacagug gcuguccccc u 21 <210> 651 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 651 acaacacagu ggcugucccc c 21 <210> 652 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 652 gacaacacag uggcuguccc c 21 <210> 653 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 653 agacaacaca guggcugucc c 21 <210> 654 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 654 uagcagacaa cacaguggcu g 21 <210> 655 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 655 guagcagaca acacaguggc u 21 <210> 656 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 656 gguagcagac aacacagugg c 21 <210> 657 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 657 aggguagcag acaacacagu g 21 <210> 658 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 658 gaggguagca gacaacacag u 21 <210> 659 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 659 ugaggguagc agacaacaca g 21 <210> 660 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 660 augaggguag cagacaacac a 21 <210> 661 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 661 gaugagggua gcagacaaca c 21 <210> 662 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 662 caggaugagg guagcagaca a 21 <210> 663 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 663 accaggauga ggguagcaga c 21 <210> 664 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 664 ugaccaggau gaggguagca g 21 <210> 665 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 665 gugaccagga ugaggguagc a 21 <210> 666 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 666 agugaccagg augaggguag c 21 <210> 667 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 667 cagugaccag gaugagggua g 21 <210> 668 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 668 gcagugacca ggaugagggu a 21 <210> 669 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 669 agcagugacc aggaugaggg u 21 <210> 670 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 670 aagcagugac caggaugagg g 21 <210> 671 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 671 agaagcagug accaggauga g 21 <210> 672 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 672 cagaagcagu gaccaggaug a 21 <210> 673 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 673 gcagaagcag ugaccaggau g 21 <210> 674 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 674 agcagaagca gugaccagga u 21 <210> 675 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 675 uagcagaagc agugaccagg a 21 <210> 676 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 676 auagcagaag cagugaccag g 21 <210> 677 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 677 uauagcagaa gcagugacca g 21 <210> 678 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 678 uuauagcaga agcagugacc a 21 <210> 679 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 679 uguuauagca gaagcaguga c 21 <210> 680 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 680 cuguuauagc agaagcagug a 21 <210> 681 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 681 gcuguuauag cagaagcagu g 21 <210> 682 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 682 gggcuguuau agcagaagca g 21 <210> 683 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 683 agggcuguua uagcagaagc a 21 <210> 684 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 684 uagggcuguu auagcagaag c 21 <210> 685 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 685 cuagggcugu uauagcagaa g 21 <210> 686 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 686 ccuagggcug uuauagcaga a 21 <210> 687 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 687 gccuagggcu guuauagcag a 21 <210> 688 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 688 ggccuagggc uguuauagca g 21 <210> 689 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 689 uggccuaggg cuguuauagc a 21 <210> 690 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 690 cuggccuagg gcuguuauag c 21 <210> 691 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 691 ccuggccuag ggcuguuaua g 21 <210> 692 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 692 uccuggccua gggcuguuau a 21 <210> 693 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 693 auuccuggcc uagggcuguu a 21 <210> 694 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 694 uauuccuggc cuagggcugu u 21 <210> 695 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 695 auauuccugg ccuagggcug u 21 <210> 696 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 696 cauauuccug gccuagggcu g 21 <210> 697 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 697 ucauauuccu ggccuagggc u 21 <210> 698 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 698 uucauauucc uggccuaggg c 21 <210> 699 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 699 guucauauuc cuggccuagg g 21 <210> 700 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 700 uguucauauu ccuggccuag g 21 <210> 701 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 701 uuguucauau uccuggccua g 21 <210> 702 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 702 cuuguucaua uuccuggccu a 21 <210> 703 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 703 gcuuguucau auuccuggcc u 21 <210> 704 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 704 ggcuuguuca uauuccuggc c 21 <210> 705 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 705 cggcuuguuc auauuccugg c 21 <210> 706 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 706 gcggcuuguu cauauuccug g 21 <210> 707 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 707 agcggcuugu ucauauuccu g 21 <210> 708 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 708 cagcggcuug uucauauucc u 21 <210> 709 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 709 gcagcggcuu guucauauuc c 21 <210> 710 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 710 agcagcggcu uguucauauu c 21 <210> 711 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 711 aagcagcggc uuguucauau u 21 <210> 712 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 712 aaagcagcgg cuuguucaua u 21 <210> 713 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 713 caaagcagcg gcuuguucau a 21 <210> 714 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 714 ccaaagcagc ggcuuguuca u 21 <210> 715 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 715 uccaaagcag cggcuuguuc a 21 <210> 716 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 716 auccaaagca gcggcuuguu c 21 <210> 717 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 717 gauccaaagc agcggcuugu u 21 <210> 718 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 718 agauccaaag cagcggcuug u 21 <210> 719 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 719 gagauccaaa gcagcggcuu g 21 <210> 720 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 720 agagauccaa agcagcggcu u 21 <210> 721 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 721 cagagaucca aagcagcggc u 21 <210> 722 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 722 acagagaucc aaagcagcgg c 21 <210> 723 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 723 gacagagauc caaagcagcg g 21 <210> 724 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 724 ggacagagau ccaaagcagc g 21 <210> 725 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 725 aggacagaga uccaaagcag c 21 <210> 726 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 726 gaggacagag auccaaagca g 21 <210> 727 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 727 ugaggacaga gauccaaagc a 21 <210> 728 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 728 gugaggacag agauccaaag c 21 <210> 729 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 729 cuggugagga cagagaucca a 21 <210> 730 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 730 gcuggugagg acagagaucc a 21 <210> 731 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 731 gaggcuggug aggacagaga u 21 <210> 732 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 732 aggaggcugg ugaggacaga g 21 <210> 733 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 733 caggaggcug gugaggacag a 21 <210> 734 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 734 ccaggaggcu ggugaggaca g 21 <210> 735 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 735 uccaggaggc uggugaggac a 21 <210> 736 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 736 cuuccaggag gcuggugagg a 21 <210> 737 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 737 gcuuccagga ggcuggugag g 21 <210> 738 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 738 aggcuuccag gaggcuggug a 21 <210> 739 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 739 aaggcuucca ggaggcuggu g 21 <210> 740 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 740 aaaggcuucc aggaggcugg u 21 <210> 741 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 741 caaaggcuuc caggaggcug g 21 <210> 742 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 742 gcaaaggcuu ccaggaggcu g 21 <210> 743 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 743 agcaaaggcu uccaggaggc u 21 <210> 744 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 744 gagcaaaggc uuccaggagg c 21 <210> 745 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 745 ugagcaaagg cuuccaggag g 21 <210> 746 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 746 gugagcaaag gcuuccagga g 21 <210> 747 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 747 ugugagcaaa ggcuuccagg a 21 <210> 748 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 748 ugugugagca aaggcuucca g 21 <210> 749 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 749 cugugugagc aaaggcuucc a 21 <210> 750 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 750 ucugugugag caaaggcuuc c 21 <210> 751 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 751 gucuguguga gcaaaggcuu c 21 <210> 752 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 752 ggucugugug agcaaaggcu u 21 <210> 753 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 753 aggucugugu gagcaaaggc u 21 <210> 754 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 754 gaggucugug ugagcaaagg c 21 <210> 755 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 755 ugaggucugu gugagcaaag g 21 <210> 756 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 756 acugaggucu gugugagcaa a 21 <210> 757 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 757 ccacugaggu cugugugagc a 21 <210> 758 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 758 ucccacugag gucuguguga g 21 <210> 759 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 759 uucccacuga ggucugugug a 21 <210> 760 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 760 cuucccacug aggucugugu g 21 <210> 761 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 761 caccuuccca cugaggucug u 21 <210> 762 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 762 acaccuuccc acugaggucu g 21 <210> 763 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 763 aacaccuucc cacugagguc u 21 <210> 764 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 764 aaacaccuuc ccacugaggu c 21 <210> 765 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 765 caaacaccuu cccacugagg u 21 <210> 766 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 766 acaaacaccu ucccacugag g 21 <210> 767 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 767 uacaaacacc uucccacuga g 21 <210> 768 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 768 auacaaacac cuucccacug a 21 <210> 769 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 769 aauacaaaca ccuucccacu g 21 <210> 770 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 770 aaauacaaac accuucccac u 21 <210> 771 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 771 gaaauacaaa caccuuccca c 21 <210> 772 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 772 ggaaauacaa acaccuuccc a 21 <210> 773 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 773 aggaaauaca aacaccuucc c 21 <210> 774 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 774 uaggaaauac aaacaccuuc c 21 <210> 775 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 775 cuaggaaaua caaacaccuu c 21 <210> 776 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 776 ucuaggaaau acaaacaccu u 21 <210> 777 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 777 cucuaggaaa uacaaacacc u 21 <210> 778 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 778 ucucuaggaa auacaaacac c 21 <210> 779 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 779 uucucuagga aauacaaaca c 21 <210> 780 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 780 auucucuagg aaauacaaac a 21 <210> 781 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 781 gauucucuag gaaauacaaa c 21 <210> 782 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 782 agauucucua ggaaauacaa a 21 <210> 783 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 783 cagauucucu aggaaauaca a 21 <210> 784 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 784 acagauucuc uaggaaauac a 21 <210> 785 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 785 aacagauucu cuaggaaaua c 21 <210> 786 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 786 uaacagauuc ucuaggaaau a 21 <210> 787 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 787 aguaacagau ucucuaggaa a 21 <210> 788 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 788 caguaacaga uucucuagga a 21 <210> 789 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 789 ucaguaacag auucucuagg a 21 <210> 790 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 790 aucaguaaca gauucucuag g 21 <210> 791 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 791 gaucaguaac agauucucua g 21 <210> 792 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 792 ugaucaguaa cagauucucu a 21 <210> 793 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 793 augaucagua acagauucuc u 21 <210> 794 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 794 caugaucagu aacagauucu c 21 <210> 795 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 795 acaugaucag uaacagauuc u 21 <210> 796 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 796 uacaugauca guaacagauu c 21 <210> 797 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 797 uuacaugauc aguaacagau u 21 <210> 798 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 798 uuuacaugau caguaacaga u 21 <210> 799 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 799 guuuacauga ucaguaacag a 21 <210> 800 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 800 aguuuacaug aucaguaaca g 21 <210> 801 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 801 ucaaguuuac augaucagua a 21 <210> 802 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 802 aucaaguuua caugaucagu a 21 <210> 803 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 803 gaucaaguuu acaugaucag u 21 <210> 804 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 804 ugaucaaguu uacaugauca g 21 <210> 805 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 805 ugugaucaag uuuacaugau c 21 <210> 806 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 806 gugugaucaa guuuacauga u 21 <210> 807 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 807 agcgguguga ucaaguuuac a 21 <210> 808 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 808 cagcggugug aucaaguuua c 21 <210> 809 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 809 uccagcggug ugaucaaguu u 21 <210> 810 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 810 ucuccagcgg ugugaucaag u 21 <210> 811 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 811 uucuccagcg gugugaucaa g 21 <210> 812 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 812 cuucuccagc ggugugauca a 21 <210> 813 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 813 aggcuucucc agcgguguga u 21 <210> 814 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 814 gaggcuucuc cagcggugug a 21 <210> 815 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 815 agaggcuucu ccagcggugu g 21 <210> 816 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 816 uagaggcuuc uccagcggug u 21 <210> 817 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 817 guagaggcuu cuccagcggu g 21 <210> 818 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 818 uguagaggcu ucuccagcgg u 21 <210> 819 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 819 cuguagaggc uucuccagcg g 21 <210> 820 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 820 ucuguagagg cuucuccagc g 21 <210> 821 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 821 uucuguagag gcuucuccag c 21 <210> 822 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 822 guucuguaga ggcuucucca g 21 <210> 823 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 823 aguucuguag aggcuucucc a 21 <210> 824 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 824 aaguucugua gaggcuucuc c 21 <210> 825 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 825 aaaguucugu agaggcuucu c 21 <210> 826 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 826 uaaaguucug uagaggcuuc u 21 <210> 827 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 827 guaaaguucu guagaggcuu c 21 <210> 828 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 828 gguaaaguuc uguagaggcu u 21 <210> 829 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 829 agguaaaguu cuguagaggc u 21 <210> 830 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 830 aagguaaagu ucuguagagg c 21 <210> 831 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 831 caagguaaag uucuguagag g 21 <210> 832 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 832 acaagguaaa guucuguaga g 21 <210> 833 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 833 cacaagguaa aguucuguag a 21 <210> 834 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 834 acacaaggua aaguucugua g 21 <210> 835 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 835 aacacaaggu aaaguucugu a 21 <210> 836 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 836 aaacacaagg uaaaguucug u 21 <210> 837 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 837 aaaacacaag guaaaguucu g 21 <210> 838 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 838 gaaaacacaa gguaaaguuc u 21 <210> 839 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 839 ucgaaaacac aagguaaagu u 21 <210> 840 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 840 aggcucgaaa acacaaggua a 21 <210> 841 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 841 uaggcucgaa aacacaaggu a 21 <210> 842 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 842 auaggcucga aaacacaagg u 21 <210> 843 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 843 uauaggcucg aaaacacaag g 21 <210> 844 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 844 acuauaggcu cgaaaacaca a 21 <210> 845 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 845 ucacuauagg cucgaaaaca c 21 <210> 846 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 846 aucacuauag gcucgaaaac a 21 <210> 847 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 847 agagaucacu auaggcucga a 21 <210> 848 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 848 gagagaucac uauaggcucg a 21 <210> 849 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 849 agagagauca cuauaggcuc g 21 <210> 850 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 850 gagagagauc acuauaggcu c 21 <210> 851 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 851 cgagagagau cacuauaggc u 21 <210> 852 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 852 acgagagaga ucacuauagg c 21 <210> 853 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 853 cacgagagag aucacuauag g 21 <210> 854 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 854 aggcacgaga gagaucacua u 21 <210> 855 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 855 uaggcacgag agagaucacu a 21 <210> 856 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 856 guaggcacga gagagaucac u 21 <210> 857 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 857 uguaggcacg agagagauca c 21 <210> 858 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 858 gaggcuguag gcacgagaga g 21 <210> 859 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 859 agaggcugua ggcacgagag a 21 <210> 860 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 860 aagaggcugu aggcacgaga g 21 <210> 861 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 861 agaagaggcu guaggcacga g 21 <210> 862 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 862 gagaagaggc uguaggcacg a 21 <210> 863 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 863 aggagaagag gcuguaggca c 21 <210> 864 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 864 uaggagaaga ggcuguaggc a 21 <210> 865 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 865 guaggagaag aggcuguagg c 21 <210> 866 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 866 uguaggagaa gaggcuguag g 21 <210> 867 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 867 uuguaggaga agaggcugua g 21 <210> 868 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 868 auuguaggag aagaggcugu a 21 <210> 869 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 869 uauuguagga gaagaggcug u 21 <210> 870 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 870 guauuguagg agaagaggcu g 21 <210> 871 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 871 gguauuguag gagaagaggc u 21 <210> 872 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 872 uggguauugu aggagaagag g 21 <210> 873 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 873 ccuuggguau uguaggagaa g 21 <210> 874 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 874 gccuugggua uuguaggaga a 21 <210> 875 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 875 ugccuugggu auuguaggag a 21 <210> 876 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 876 cugccuuggg uauuguagga g 21 <210> 877 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 877 ccugccuugg guauuguagg a 21 <210> 878 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 878 aucccugccu uggguauugu a 21 <210> 879 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 879 uuaucccugc cuuggguauu g 21 <210> 880 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 880 auuaucccug ccuuggguau u 21 <210> 881 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 881 cucauuaucc cugccuuggg u 21 <210> 882 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 882 agcucauuau cccugccuug g 21 <210> 883 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 883 uagcucauua ucccugccuu g 21 <210> 884 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 884 aguagcucau uaucccugcc u 21 <210> 885 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 885 uaguagcuca uuaucccugc c 21 <210> 886 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 886 cuaguagcuc auuaucccug c 21 <210> 887 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 887 acuaguagcu cauuaucccu g 21 <210> 888 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 888 aacuaguagc ucauuauccc u 21 <210> 889 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 889 aaacuaguag cucauuaucc c 21 <210> 890 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 890 uaaacuagua gcucauuauc c 21 <210> 891 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 891 auaaacuagu agcucauuau c 21 <210> 892 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 892 uuauaaacua guagcucauu a 21 <210> 893 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 893 uuuauaaacu aguagcucau u 21 <210> 894 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 894 cuuuauaaac uaguagcuca u 21 <210> 895 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 895 ucuuuauaaa cuaguagcuc a 21 <210> 896 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 896 uucuuuauaa acuaguagcu c 21 <210> 897 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 897 uuucuuuaua aacuaguagc u 21 <210> 898 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 898 aacucuuucu uuauaaacua g 21 <210> 899 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 899 uacucuccaa cucuuucuuu a 21 <210> 900 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 900 auacucucca acucuuucuu u 21 <210> 901 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 901 uauacucucc aacucuuucu u 21 <210> 902 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 902 acuauacucu ccaacucuuu c 21 <210> 903 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 903 gacuauacuc uccaacucuu u 21 <210> 904 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 904 agacuauacu cuccaacucu u 21 <210> 905 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 905 uagacuauac ucuccaacuc u 21 <210> 906 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 906 auagacuaua cucuccaacu c 21 <210> 907 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 907 uauagacuau acucuccaac u 21 <210> 908 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 908 guauagacua uacucuccaa c 21 <210> 909 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 909 uguauagacu auacucucca a 21 <210> 910 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 910 auguauagac uauacucucc a 21 <210> 911 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 911 aauguauaga cuauacucuc c 21 <210> 912 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 912 caauguauag acuauacucu c 21 <210> 913 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 913 ccaauguaua gacuauacuc u 21 <210> 914 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 914 uccaauguau agacuauacu c 21 <210> 915 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 915 ugucuuccaa uguauagacu a 21 <210> 916 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 916 ugugucuucc aauguauaga c 21 <210> 917 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 917 uugugucuuc caauguauag a 21 <210> 918 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 918 uuugugucuu ccaauguaua g 21 <210> 919 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 919 acuuuguguc uuccaaugua u 21 <210> 920 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 920 aacuuugugu cuuccaaugu a 21 <210> 921 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 921 uaacuuugug ucuuccaaug u 21 <210> 922 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 922 uguaacuuug ugucuuccaa u 21 <210> 923 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 923 auguaacuuu gugucuucca a 21 <210> 924 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 924 gauguaacuu ugugucuucc a 21 <210> 925 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 925 ggauguaacu uugugucuuc c 21 <210> 926 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 926 uggauguaac uuugugucuu c 21 <210> 927 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 927 uuggauguaa cuuugugucu u 21 <210> 928 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 928 uuuggaugua acuuuguguc u 21 <210> 929 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 929 cuuuggaugu aacuuugugu c 21 <210> 930 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 930 aacuuuggau guaacuuugu g 21 <210> 931 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 931 uaacuuugga uguaacuuug u 21 <210> 932 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 932 auaacuuugg auguaacuuu g 21 <210> 933 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 933 gauaacuuug gauguaacuu u 21 <210> 934 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 934 cgauaacuuu ggauguaacu u 21 <210> 935 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 935 ucgauaacuu uggauguaac u 21 <210> 936 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 936 uucgauaacu uuggauguaa c 21 <210> 937 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 937 uuucgauaac uuuggaugua a 21 <210> 938 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 938 uuuucgauaa cuuuggaugu a 21 <210> 939 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 939 cuuuucgaua acuuuggaug u 21 <210> 940 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 940 acuuuucgau aacuuuggau g 21 <210> 941 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 941 aacuuuucga uaacuuugga u 21 <210> 942 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 942 gaacuuuucg auaacuuugg a 21 <210> 943 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 943 uggagccggg aacuuuucga u 21 <210> 944 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 944 acuggagccg ggaacuuuuc g 21 <210> 945 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 945 gaugugcacu ggagccggga a 21 <210> 946 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 946 cagaugugca cuggagccgg g 21 <210> 947 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 947 acagaugugc acuggagccg g 21 <210> 948 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 948 cacagaugug cacuggagcc g 21 <210> 949 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 949 acacagaugu gcacuggagc c 21 <210> 950 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 950 ucacacagau gugcacugga g 21 <210> 951 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 951 agcucacaca gaugugcacu g 21 <210> 952 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 952 ccagcucaca cagaugugca c 21 <210> 953 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 953 ucccagcuca cacagaugug c 21 <210> 954 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 954 acucccagcu cacacagaug u 21 <210> 955 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 955 aggacuccca gcucacacag a 21 <210> 956 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 956 gaggacuccc agcucacaca g 21 <210> 957 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 957 cugaugagga cucccagcuc a 21 <210> 958 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 958 ccugaugagg acucccagcu c 21 <210> 959 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 959 accugaugag gacucccagc u 21 <210> 960 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 960 uaccugauga ggacucccag c 21 <210> 961 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 961 auaccugaug aggacuccca g 21 <210> 962 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 962 aauaccugau gaggacuccc a 21 <210> 963 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 963 caauaccuga ugaggacucc c 21 <210> 964 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 964 agcaauaccu gaugaggacu c 21 <210> 965 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 965 cagcaauacc ugaugaggac u 21 <210> 966 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 966 ucagcaauac cugaugagga c 21 <210> 967 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 967 uucagcaaua ccugaugagg a 21 <210> 968 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 968 auucagcaau accugaugag g 21 <210> 969 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 969 aauucagcaa uaccugauga g 21 <210> 970 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 970 aaauucagca auaccugaug a 21 <210> 971 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 971 aaaauucagc aauaccugau g 21 <210> 972 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 972 caaaauucag caauaccuga u 21 <210> 973 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 973 ccaaaauuca gcaauaccug a 21 <210> 974 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 974 uccaaaauuc agcaauaccu g 21 <210> 975 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 975 auccaaaauu cagcaauacc u 21 <210> 976 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 976 ugauccaaaa uucagcaaua c 21 <210> 977 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 977 auugauccaa aauucagcaa u 21 <210> 978 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 978 cauugaucca aaauucagca a 21 <210> 979 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 979 ccauugaucc aaaauucagc a 21 <210> 980 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 980 ucccauugau ccaaaauuca g 21 <210> 981 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 981 aaaggugucc cauugaucca a 21 <210> 982 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 982 caccaaaggu gucccauuga u 21 <210> 983 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 983 ucaccaaagg ugucccauug a 21 <210> 984 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 984 uucaccaaag gugucccauu g 21 <210> 985 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 985 uuucaccaaa ggugucccau u 21 <210> 986 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 986 uuuucaccaa agguguccca u 21 <210> 987 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 987 uuuuucacca aagguguccc a 21 <210> 988 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 988 acccuuuuuc accaaaggug u 21 <210> 989 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 989 gacccuuuuu caccaaaggu g 21 <210> 990 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 990 agacccuuuu ucaccaaagg u 21 <210> 991 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 991 ucgcagaccc uuuuucacca a 21 <210> 992 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 992 gucgcagacc cuuuuucacc a 21 <210> 993 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 993 ugucgcagac ccuuuuucac c 21 <210> 994 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 994 cugucgcaga cccuuuuuca c 21 <210> 995 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 995 acccugucgc agacccuuuu u 21 <210> 996 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 996 aacccugucg cagacccuuu u 21 <210> 997 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 997 uaacccuguc gcagacccuu u 21 <210> 998 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 998 guaacccugu cgcagacccu u 21 <210> 999 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 999 aguaacccug ucgcagaccc u 21 <210> 1000 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1000 aaguaacccu gucgcagacc c 21 <210> 1001 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1001 aaaguaaccc ugucgcagac c 21 <210> 1002 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1002 caaaguaacc cugucgcaga c 21 <210> 1003 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1003 acaaaguaac ccugucgcag a 21 <210> 1004 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1004 uacaaaguaa cccugucgca g 21 <210> 1005 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1005 cuacaaagua acccugucgc a 21 <210> 1006 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1006 ucuacaaagu aacccugucg c 21 <210> 1007 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1007 uucuacaaag uaacccuguc g 21 <210> 1008 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1008 cuucuacaaa guaacccugu c 21 <210> 1009 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1009 gcuucuacaa aguaacccug u 21 <210> 1010 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1010 agcuucuaca aaguaacccu g 21 <210> 1011 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1011 gagcuucuac aaaguaaccc u 21 <210> 1012 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1012 ugagcuucua caaaguaacc c 21 <210> 1013 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1013 aaucuugggc ugagcuucua c 21 <210> 1014 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1014 caaucuuggg cugagcuucu a 21 <210> 1015 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1015 acaaucuugg gcugagcuuc u 21 <210> 1016 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1016 gacaaucuug ggcugagcuu c 21 <210> 1017 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1017 aggacaaucu ugggcugagc u 21 <210> 1018 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1018 cccaggacaa ucuugggcug a 21 <210> 1019 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1019 ugccccagga caaucuuggg c 21 <210> 1020 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1020 cugccccagg acaaucuugg g 21 <210> 1021 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1021 uccugcccca ggacaaucuu g 21 <210> 1022 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1022 uuccugcccc aggacaaucu u 21 <210> 1023 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1023 uguuccugcc ccaggacaau c 21 <210> 1024 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1024 uccuguuccu gccccaggac a 21 <210> 1025 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1025 aauccuguuc cugccccagg a 21 <210> 1026 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1026 gaauccuguu ccugccccag g 21 <210> 1027 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1027 ggaauccugu uccugcccca g 21 <210> 1028 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1028 uaggaauccu guuccugccc c 21 <210> 1029 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1029 auaggaaucc uguuccugcc c 21 <210> 1030 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1030 cauaggaauc cuguuccugc c 21 <210> 1031 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1031 cccauaggaa uccuguuccu g 21 <210> 1032 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1032 ccccauagga auccuguucc u 21 <210> 1033 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1033 gcccccauag gaauccuguu c 21 <210> 1034 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1034 ugcccccaua ggaauccugu u 21 <210> 1035 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1035 cuugccccca uaggaauccu g 21 <210> 1036 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1036 acuugccccc auaggaaucc u 21 <210> 1037 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1037 aacuugcccc cauaggaauc c 21 <210> 1038 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1038 aaacuugccc ccauaggaau c 21 <210> 1039 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1039 caaacuugcc cccauaggaa u 21 <210> 1040 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1040 ucaaacuugc ccccauagga a 21 <210> 1041 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1041 aucaaacuug cccccauagg a 21 <210> 1042 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1042 uaucaaacuu gcccccauag g 21 <210> 1043 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1043 uccuaucaaa cuugccccca u 21 <210> 1044 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1044 cuccuaucaa acuugccccc a 21 <210> 1045 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1045 gcuccuauca aacuugcccc c 21 <210> 1046 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1046 ggcuccuauc aaacuugccc c 21 <210> 1047 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1047 uggcuccuau caaacuugcc c 21 <210> 1048 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1048 cuggcuccua ucaaacuugc c 21 <210> 1049 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1049 acuggcuccu aucaaacuug c 21 <210> 1050 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1050 aaggacuggc uccuaucaaa c 21 <210> 1051 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1051 aaaggacugg cuccuaucaa a 21 <210> 1052 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1052 caaaggacug gcuccuauca a 21 <210> 1053 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1053 acaaaggacu ggcuccuauc a 21 <210> 1054 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1054 ccacaaagga cuggcuccua u 21 <210> 1055 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1055 cccacaaagg acuggcuccu a 21 <210> 1056 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1056 ucccacaaag gacuggcucc u 21 <210> 1057 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1057 cucccacaaa ggacuggcuc c 21 <210> 1058 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1058 ucucccacaa aggacuggcu c 21 <210> 1059 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1059 cucucccaca aaggacuggc u 21 <210> 1060 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1060 ucucucccac aaaggacugg c 21 <210> 1061 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1061 aucucuccca caaaggacug g 21 <210> 1062 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1062 aaucucuccc acaaaggacu g 21 <210> 1063 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1063 caaucucucc cacaaaggac u 21 <210> 1064 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1064 ccaaucucuc ccacaaagga c 21 <210> 1065 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1065 cccaaucucu cccacaaagg a 21 <210> 1066 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1066 uccccaaucu cucccacaaa g 21 <210> 1067 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1067 auccccaauc ucucccacaa a 21 <210> 1068 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1068 aauccccaau cucucccaca a 21 <210> 1069 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1069 aaauccccaa ucucucccac a 21 <210> 1070 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1070 caaaucccca aucucuccca c 21 <210> 1071 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1071 acaaaucccc aaucucuccc a 21 <210> 1072 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1072 uacaaauccc caaucucucc c 21 <210> 1073 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1073 guacaaaucc ccaaucucuc c 21 <210> 1074 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1074 uguacaaauc cccaaucucu c 21 <210> 1075 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1075 auguacaaau ccccaaucuc u 21 <210> 1076 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1076 cccacaugua caaaucccca a 21 <210> 1077 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1077 ucccacaugu acaaaucccc a 21 <210> 1078 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1078 gucccacaug uacaaauccc c 21 <210> 1079 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1079 agucccacau guacaaaucc c 21 <210> 1080 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1080 acagaguccc acauguacaa a 21 <210> 1081 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1081 cacagagucc cacauguaca a 21 <210> 1082 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1082 agcacagagu cccacaugua c 21 <210> 1083 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1083 gggggcagca cagaguccca c 21 <210> 1084 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1084 ugggggcagc acagaguccc a 21 <210> 1085 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1085 ucugggggca gcacagaguc c 21 <210> 1086 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1086 uucugggggc agcacagagu c 21 <210> 1087 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1087 uuuucugggg gcagcacaga g 21 <210> 1088 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1088 auuuucuggg ggcagcacag a 21 <210> 1089 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1089 uauuuucugg gggcagcaca g 21 <210> 1090 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1090 gauauuuucu gggggcagca c 21 <210> 1091 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1091 acaggauauu uucugggggc a 21 <210> 1092 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1092 agacaggaua uuuucugggg g 21 <210> 1093 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1093 cagacaggau auuuucuggg g 21 <210> 1094 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1094 gcagacagga uauuuucugg g 21 <210> 1095 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1095 aggcagacag gauauuuucu g 21 <210> 1096 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1096 uaggcagaca ggauauuuuc u 21 <210> 1097 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1097 auaggcagac aggauauuuu c 21 <210> 1098 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1098 acccugauag gcagacagga u 21 <210> 1099 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1099 uacccugaua ggcagacagg a 21 <210> 1100 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1100 gguacccuga uaggcagaca g 21 <210> 1101 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1101 agggguaccc ugauaggcag a 21 <210> 1102 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1102 gagggguacc cugauaggca g 21 <210> 1103 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1103 agagggguac ccugauaggc a 21 <210> 1104 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1104 gagaggggua cccugauagg c 21 <210> 1105 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1105 cagggagagg gguacccuga u 21 <210> 1106 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1106 ggcagggaga gggguacccu g 21 <210> 1107 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1107 uggcagggag agggguaccc u 21 <210> 1108 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1108 uuggcaggga gagggguacc c 21 <210> 1109 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1109 auuggcaggg agagggguac c 21 <210> 1110 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1110 auauuggcag ggagaggggu a 21 <210> 1111 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1111 gauauuggca gggagagggg u 21 <210> 1112 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1112 caguccagga uauuggcagg g 21 <210> 1113 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1113 ugccagucca ggauauuggc a 21 <210> 1114 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1114 cugccagucc aggauauugg c 21 <210> 1115 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1115 agagccugcc aguccaggau a 21 <210> 1116 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1116 cagagccugc caguccagga u 21 <210> 1117 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1117 ucagagccug ccaguccagg a 21 <210> 1118 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1118 uucagagccu gccaguccag g 21 <210> 1119 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1119 guucagagcc ugccagucca g 21 <210> 1120 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1120 aguucagagc cugccagucc a 21 <210> 1121 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1121 uaguucagag ccugccaguc c 21 <210> 1122 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1122 auaguucaga gccugccagu c 21 <210> 1123 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1123 cauaguucag agccugccag u 21 <210> 1124 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1124 ucauaguuca gagccugcca g 21 <210> 1125 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1125 uucauaguuc agagccugcc a 21 <210> 1126 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1126 uuucauaguu cagagccugc c 21 <210> 1127 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1127 auuucauagu ucagagccug c 21 <210> 1128 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1128 gauuucauag uucagagccu g 21 <210> 1129 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1129 ugauuucaua guucagagcc u 21 <210> 1130 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1130 cugauuucau aguucagagc c 21 <210> 1131 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1131 ucugauuuca uaguucagag c 21 <210> 1132 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1132 uccucugauu ucauaguuca g 21 <210> 1133 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1133 auccucugau uucauaguuc a 21 <210> 1134 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1134 uauccucuga uuucauaguu c 21 <210> 1135 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1135 auauccucug auuucauagu u 21 <210> 1136 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1136 cauauccucu gauuucauag u 21 <210> 1137 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1137 gacauauccu cugauuucau a 21 <210> 1138 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1138 ugacauaucc ucugauuuca u 21 <210> 1139 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1139 augacauauc cucugauuuc a 21 <210> 1140 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1140 gaugacauau ccucugauuu c 21 <210> 1141 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1141 gaugaugaca uauccucuga u 21 <210> 1142 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1142 ugaugaugac auauccucug a 21 <210> 1143 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1143 uugaugauga cauauccucu g 21 <210> 1144 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1144 uuugaugaug acauauccuc u 21 <210> 1145 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1145 guuugaugau gacauauccu c 21 <210> 1146 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1146 gguuugauga ugacauaucc u 21 <210> 1147 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1147 aaggguuuga ugaugacaua u 21 <210> 1148 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1148 caccaagggu uugaugauga c 21 <210> 1149 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1149 cacaccaagg guuugaugau g 21 <210> 1150 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1150 ucagacccac accaaggguu u 21 <210> 1151 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1151 cucagaccca caccaagggu u 21 <210> 1152 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1152 ccucagaccc acaccaaggg u 21 <210> 1153 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1153 accucagacc cacaccaagg g 21 <210> 1154 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1154 agaccucaga cccacaccaa g 21 <210> 1155 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1155 aagaccucag acccacacca a 21 <210> 1156 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1156 caagaccuca gacccacacc a 21 <210> 1157 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1157 ucaagaccuc agacccacac c 21 <210> 1158 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1158 gucaagaccu cagacccaca c 21 <210> 1159 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1159 gagucaagac cucagaccca c 21 <210> 1160 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1160 ugagucaaga ccucagaccc a 21 <210> 1161 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1161 uugagucaag accucagacc c 21 <210> 1162 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1162 cguugaguca agaccucaga c 21 <210> 1163 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1163 ucguugaguc aagaccucag a 21 <210> 1164 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1164 cucguugagu caagaccuca g 21 <210> 1165 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1165 ucucguugag ucaagaccuc a 21 <210> 1166 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1166 cucucguuga gucaagaccu c 21 <210> 1167 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1167 gcucucguug agucaagacc u 21 <210> 1168 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1168 ugcucucguu gagucaagac c 21 <210> 1169 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1169 gugcucucgu ugagucaaga c 21 <210> 1170 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1170 agugcucucg uugagucaag a 21 <210> 1171 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1171 aagugcucuc guugagucaa g 21 <210> 1172 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1172 caagugcucu cguugaguca a 21 <210> 1173 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1173 ucaagugcuc ucguugaguc a 21 <210> 1174 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1174 uucaagugcu cucguugagu c 21 <210> 1175 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1175 uuucaagugc ucucguugag u 21 <210> 1176 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1176 uuuucaagug cucucguuga g 21 <210> 1177 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1177 auuuucaagu gcucucguug a 21 <210> 1178 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1178 cauuuucaag ugcucucguu g 21 <210> 1179 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1179 ucauuuucaa gugcucucgu u 21 <210> 1180 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1180 uucauuuuca agugcucucg u 21 <210> 1181 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1181 uuucauuuuc aagugcucuc g 21 <210> 1182 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1182 auuucauuuu caagugcucu c 21 <210> 1183 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1183 cauuucauuu ucaagugcuc u 21 <210> 1184 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1184 ucauuucauu uucaagugcu c 21 <210> 1185 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1185 gucauuucau uuucaagugc u 21 <210> 1186 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1186 agucauuuca uuuucaagug c 21 <210> 1187 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1187 cagucauuuc auuuucaagu g 21 <210> 1188 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1188 acagucauuu cauuuucaag u 21 <210> 1189 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1189 gacagucauu ucauuuucaa g 21 <210> 1190 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1190 agacagucau uucauuuuca a 21 <210> 1191 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1191 uagacaguca uuucauuuuc a 21 <210> 1192 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1192 uuagacaguc auuucauuuu c 21 <210> 1193 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1193 cuuagacagu cauuucauuu u 21 <210> 1194 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1194 ucuuagacag ucauuucauu u 21 <210> 1195 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1195 cucuuagaca gucauuucau u 21 <210> 1196 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1196 ucucuuagac agucauuuca u 21 <210> 1197 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1197 aucucuuaga cagucauuuc a 21 <210> 1198 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1198 agaucucuua gacagucauu u 21 <210> 1199 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1199 cagaucucuu agacagucau u 21 <210> 1200 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1200 ccagaucucu uagacaguca u 21 <210> 1201 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1201 accagaucuc uuagacaguc a 21 <210> 1202 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1202 gaccagaucu cuuagacagu c 21 <210> 1203 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1203 ugaccagauc ucuuagacag u 21 <210> 1204 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1204 uugaccagau cucuuagaca g 21 <210> 1205 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1205 uuugaccaga ucucuuagac a 21 <210> 1206 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1206 cuuugaccag aucucuuaga c 21 <210> 1207 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1207 gcuuugacca gaucucuuag a 21 <210> 1208 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1208 ugcuuugacc agaucucuua g 21 <210> 1209 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1209 uugcuuugac cagaucucuu a 21 <210> 1210 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1210 guugcuuuga ccagaucucu u 21 <210> 1211 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1211 aguugcuuug accagaucuc u 21 <210> 1212 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1212 caguugcuuu gaccagaucu c 21 <210> 1213 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1213 ccaguugcuu ugaccagauc u 21 <210> 1214 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1214 uccaguugcu uugaccagau c 21 <210> 1215 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1215 auccaguugc uuugaccaga u 21 <210> 1216 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1216 uauccaguug cuuugaccag a 21 <210> 1217 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1217 guauccaguu gcuuugacca g 21 <210> 1218 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1218 aguauccagu ugcuuugacc a 21 <210> 1219 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1219 uaguauccag uugcuuugac c 21 <210> 1220 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1220 cuaguaucca guugcuuuga c 21 <210> 1221 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1221 ucuaguaucc aguugcuuug a 21 <210> 1222 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1222 aucuaguauc caguugcuuu g 21 <210> 1223 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1223 gaucuaguau ccaguugcuu u 21 <210> 1224 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1224 agaucuagua uccaguugcu u 21 <210> 1225 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1225 aagaucuagu auccaguugc u 21 <210> 1226 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1226 uaagaucuag uauccaguug c 21 <210> 1227 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1227 guaagaucua guauccaguu g 21 <210> 1228 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1228 uguaagaucu aguauccagu u 21 <210> 1229 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1229 auguaagauc uaguauccag u 21 <210> 1230 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1230 gauguaagau cuaguaucca g 21 <210> 1231 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1231 agauguaaga ucuaguaucc a 21 <210> 1232 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1232 cagauguaag aucuaguauc c 21 <210> 1233 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1233 ugcagaugua agaucuagua u 21 <210> 1234 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1234 cugcagaugu aagaucuagu a 21 <210> 1235 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1235 agcugcagau guaagaucua g 21 <210> 1236 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1236 gagcugcaga uguaagaucu a 21 <210> 1237 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1237 agagcugcag auguaagauc u 21 <210> 1238 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1238 aagagcugca gauguaagau c 21 <210> 1239 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1239 aaagagcugc agauguaaga u 21 <210> 1240 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1240 gaaagagcug cagauguaag a 21 <210> 1241 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1241 agaaagagcu gcagauguaa g 21 <210> 1242 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1242 aagaaagagc ugcagaugua a 21 <210> 1243 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1243 gaagaaagag cugcagaugu a 21 <210> 1244 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1244 agaagaaaga gcugcagaug u 21 <210> 1245 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1245 aagaagaaag agcugcagau g 21 <210> 1246 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1246 aaagaagaaa gagcugcaga u 21 <210> 1247 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1247 caaagaagaa agagcugcag a 21 <210> 1248 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1248 ucaaagaaga aagagcugca g 21 <210> 1249 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1249 uucaaagaag aaagagcugc a 21 <210> 1250 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1250 auucaaagaa gaaagagcug c 21 <210> 1251 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1251 aauucaaaga agaaagagcu g 21 <210> 1252 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1252 aaauucaaag aagaaagagc u 21 <210> 1253 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1253 gaaauucaaa gaagaaagag c 21 <210> 1254 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1254 ggaaauucaa agaagaaaga g 21 <210> 1255 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1255 aggaaauuca aagaagaaag a 21 <210> 1256 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1256 uaggaaauuc aaagaagaaa g 21 <210> 1257 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1257 auaggaaauu caaagaagaa a 21 <210> 1258 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1258 agauaggaaa uucaaagaag a 21 <210> 1259 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1259 cagauaggaa auucaaagaa g 21 <210> 1260 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1260 acagauagga aauucaaaga a 21 <210> 1261 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1261 uacagauagg aaauucaaag a 21 <210> 1262 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1262 auacagauag gaaauucaaa g 21 <210> 1263 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1263 cauacagaua ggaaauucaa a 21 <210> 1264 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1264 acauacagau aggaaauuca a 21 <210> 1265 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1265 agacauacag auaggaaauu c 21 <210> 1266 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1266 cagacauaca gauaggaaau u 21 <210> 1267 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1267 gcagacauac agauaggaaa u 21 <210> 1268 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1268 ggcagacaua cagauaggaa a 21 <210> 1269 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1269 aggcagacau acagauagga a 21 <210> 1270 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1270 uaggcagaca uacagauagg a 21 <210> 1271 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1271 uuaggcagac auacagauag g 21 <210> 1272 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1272 auuaggcaga cauacagaua g 21 <210> 1273 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1273 aauuaggcag acauacagau a 21 <210> 1274 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1274 uaauuaggca gacauacaga u 21 <210> 1275 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1275 uuaauuaggc agacauacag a 21 <210> 1276 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1276 uuuaauuagg cagacauaca g 21 <210> 1277 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1277 uuuuaauuag gcagacauac a 21 <210> 1278 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1278 uuuuuaauua ggcagacaua c 21 <210> 1279 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1279 uuuuuuaauu aggcagacau a 21 <210> 1280 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1280 uuuuuuuaau uaggcagaca u 21 <210> 1281 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1281 auuuuuuuaa uuaggcagac a 21 <210> 1282 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1282 uauuuuuuua auuaggcaga c 21 <210> 1283 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1283 auauuuuuuu aauuaggcag a 21 <210> 1284 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1284 uauauuuuuu uaauuaggca g 21 <210> 1285 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1285 auauauuuuu uuaauuaggc a 21 <210> 1286 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1286 uauauauuuu uuuaauuagg c 21 <210> 1287 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <400> 1287 uacaauauau auuuuuuuaa u 21 <210> 1288 <211> 19 <212> RNA <213> Homo sapiens <400> 1288 gcaugaauau cagacgcua 19 <210> 1289 <211> 19 <212> RNA <213> Homo sapiens <400> 1289 caugaauauc agacgcuag 19 <210> 1290 <211> 19 <212> RNA <213> Homo sapiens <400> 1290 auaucagacg cuaggggga 19 <210> 1291 <211> 19 <212> RNA <213> Homo sapiens <400> 1291 cuagggggac agccacugu 19 <210> 1292 <211> 19 <212> RNA <213> Homo sapiens <400> 1292 agggggacag ccacugugu 19 <210> 1293 <211> 19 <212> RNA <213> Homo sapiens <400> 1293 ggggacagcc acuguguug 19 <210> 1294 <211> 19 <212> RNA <213> Homo sapiens <400> 1294 gggacagcca cuguguugu 19 <210> 1295 <211> 19 <212> RNA <213> Homo sapiens <400> 1295 ggacagccac uguguuguc 19 <210> 1296 <211> 19 <212> RNA <213> Homo sapiens <400> 1296 gacagccacu guguugucu 19 <210> 1297 <211> 19 <212> RNA <213> Homo sapiens <400> 1297 gccacugugu ugucugcua 19 <210> 1298 <211> 19 <212> RNA <213> Homo sapiens <400> 1298 ccacuguguu gucugcuac 19 <210> 1299 <211> 19 <212> RNA <213> Homo sapiens <400> 1299 cacuguguug ucugcuacc 19 <210> 1300 <211> 19 <212> RNA <213> Homo sapiens <400> 1300 cuguguuguc ugcuacccu 19 <210> 1301 <211> 19 <212> RNA <213> Homo sapiens <400> 1301 uguguugucu gcuacccuc 19 <210> 1302 <211> 19 <212> RNA <213> Homo sapiens <400> 1302 guguugucug cuacccuca 19 <210> 1303 <211> 19 <212> RNA <213> Homo sapiens <400> 1303 uguugucugc uacccucau 19 <210> 1304 <211> 19 <212> RNA <213> Homo sapiens <400> 1304 guugucugcu acccucauc 19 <210> 1305 <211> 19 <212> RNA <213> Homo sapiens <400> 1305 gucugcuacc cucauccug 19 <210> 1306 <211> 19 <212> RNA <213> Homo sapiens <400> 1306 cugcuacccu cauccuggu 19 <210> 1307 <211> 19 <212> RNA <213> Homo sapiens <400> 1307 gcuacccuca uccugguca 19 <210> 1308 <211> 19 <212> RNA <213> Homo sapiens <400> 1308 cuacccucau ccuggucac 19 <210> 1309 <211> 19 <212> RNA <213> Homo sapiens <400> 1309 uacccucauc cuggucacu 19 <210> 1310 <211> 19 <212> RNA <213> Homo sapiens <400> 1310 acccucaucc uggucacug 19 <210> 1311 <211> 19 <212> RNA <213> Homo sapiens <400> 1311 cccucauccu ggucacugc 19 <210> 1312 <211> 19 <212> RNA <213> Homo sapiens <400> 1312 ccucauccug gucacugcu 19 <210> 1313 <211> 19 <212> RNA <213> Homo sapiens <400> 1313 cucauccugg ucacugcuu 19 <210> 1314 <211> 19 <212> RNA <213> Homo sapiens <400> 1314 cauccugguc acugcuucu 19 <210> 1315 <211> 19 <212> RNA <213> Homo sapiens <400> 1315 auccugguca cugcuucug 19 <210> 1316 <211> 19 <212> RNA <213> Homo sapiens <400> 1316 uccuggucac ugcuucugc 19 <210> 1317 <211> 19 <212> RNA <213> Homo sapiens <400> 1317 ccuggucacu gcuucugcu 19 <210> 1318 <211> 19 <212> RNA <213> Homo sapiens <400> 1318 cuggucacug cuucugcua 19 <210> 1319 <211> 19 <212> RNA <213> Homo sapiens <400> 1319 uggucacugc uucugcuau 19 <210> 1320 <211> 19 <212> RNA <213> Homo sapiens <400> 1320 ggucacugcu ucugcuaua 19 <210> 1321 <211> 19 <212> RNA <213> Homo sapiens <400> 1321 gucacugcuu cugcuauaa 19 <210> 1322 <211> 19 <212> RNA <213> Homo sapiens <400> 1322 cacugcuucu gcuauaaca 19 <210> 1323 <211> 19 <212> RNA <213> Homo sapiens <400> 1323 acugcuucug cuauaacag 19 <210> 1324 <211> 19 <212> RNA <213> Homo sapiens <400> 1324 cugcuucugc uauaacagc 19 <210> 1325 <211> 19 <212> RNA <213> Homo sapiens <400> 1325 gcuucugcua uaacagccc 19 <210> 1326 <211> 19 <212> RNA <213> Homo sapiens <400> 1326 cuucugcuau aacagcccu 19 <210> 1327 <211> 19 <212> RNA <213> Homo sapiens <400> 1327 uucugcuaua acagcccua 19 <210> 1328 <211> 19 <212> RNA <213> Homo sapiens <400> 1328 ucugcuauaa cagcccuag 19 <210> 1329 <211> 19 <212> RNA <213> Homo sapiens <400> 1329 cugcuauaac agcccuagg 19 <210> 1330 <211> 19 <212> RNA <213> Homo sapiens <400> 1330 ugcuauaaca gcccuaggc 19 <210> 1331 <211> 19 <212> RNA <213> Homo sapiens <400> 1331 gcuauaacag cccuaggcc 19 <210> 1332 <211> 19 <212> RNA <213> Homo sapiens <400> 1332 cuauaacagc ccuaggcca 19 <210> 1333 <211> 19 <212> RNA <213> Homo sapiens <400> 1333 uauaacagcc cuaggccag 19 <210> 1334 <211> 19 <212> RNA <213> Homo sapiens <400> 1334 auaacagccc uaggccagg 19 <210> 1335 <211> 19 <212> RNA <213> Homo sapiens <400> 1335 uaacagcccu aggccagga 19 <210> 1336 <211> 19 <212> RNA <213> Homo sapiens <400> 1336 acagcccuag gccaggaau 19 <210> 1337 <211> 19 <212> RNA <213> Homo sapiens <400> 1337 cagcccuagg ccaggaaua 19 <210> 1338 <211> 19 <212> RNA <213> Homo sapiens <400> 1338 agcccuaggc caggaauau 19 <210> 1339 <211> 19 <212> RNA <213> Homo sapiens <400> 1339 gcccuaggcc aggaauaug 19 <210> 1340 <211> 19 <212> RNA <213> Homo sapiens <400> 1340 cccuaggcca ggaauauga 19 <210> 1341 <211> 19 <212> RNA <213> Homo sapiens <400> 1341 ccuaggccag gaauaugaa 19 <210> 1342 <211> 19 <212> RNA <213> Homo sapiens <400> 1342 cuaggccagg aauaugaac 19 <210> 1343 <211> 19 <212> RNA <213> Homo sapiens <400> 1343 uaggccagga auaugaaca 19 <210> 1344 <211> 19 <212> RNA <213> Homo sapiens <400> 1344 aggccaggaa uaugaacaa 19 <210> 1345 <211> 19 <212> RNA <213> Homo sapiens <400> 1345 ggccaggaau augaacaag 19 <210> 1346 <211> 19 <212> RNA <213> Homo sapiens <400> 1346 gccaggaaua ugaacaagc 19 <210> 1347 <211> 19 <212> RNA <213> Homo sapiens <400> 1347 ccaggaauau gaacaagcc 19 <210> 1348 <211> 19 <212> RNA <213> Homo sapiens <400> 1348 caggaauaug aacaagccg 19 <210> 1349 <211> 19 <212> RNA <213> Homo sapiens <400> 1349 aggaauauga acaagccgc 19 <210> 1350 <211> 19 <212> RNA <213> Homo sapiens <400> 1350 ggaauaugaa caagccgcu 19 <210> 1351 <211> 19 <212> RNA <213> Homo sapiens <400> 1351 gaauaugaac aagccgcug 19 <210> 1352 <211> 19 <212> RNA <213> Homo sapiens <400> 1352 aauaugaaca agccgcugc 19 <210> 1353 <211> 19 <212> RNA <213> Homo sapiens <400> 1353 auaugaacaa gccgcugcu 19 <210> 1354 <211> 19 <212> RNA <213> Homo sapiens <400> 1354 uaugaacaag ccgcugcuu 19 <210> 1355 <211> 19 <212> RNA <213> Homo sapiens <400> 1355 augaacaagc cgcugcuuu 19 <210> 1356 <211> 19 <212> RNA <213> Homo sapiens <400> 1356 ugaacaagcc gcugcuuug 19 <210> 1357 <211> 19 <212> RNA <213> Homo sapiens <400> 1357 gaacaagccg cugcuuugg 19 <210> 1358 <211> 19 <212> RNA <213> Homo sapiens <400> 1358 aacaagccgc ugcuuugga 19 <210> 1359 <211> 19 <212> RNA <213> Homo sapiens <400> 1359 acaagccgcu gcuuuggau 19 <210> 1360 <211> 19 <212> RNA <213> Homo sapiens <400> 1360 caagccgcug cuuuggauc 19 <210> 1361 <211> 19 <212> RNA <213> Homo sapiens <400> 1361 aagccgcugc uuuggaucu 19 <210> 1362 <211> 19 <212> RNA <213> Homo sapiens <400> 1362 agccgcugcu uuggaucuc 19 <210> 1363 <211> 19 <212> RNA <213> Homo sapiens <400> 1363 gccgcugcuu uggaucucu 19 <210> 1364 <211> 19 <212> RNA <213> Homo sapiens <400> 1364 ccgcugcuuu ggaucucug 19 <210> 1365 <211> 19 <212> RNA <213> Homo sapiens <400> 1365 cgcugcuuug gaucucugu 19 <210> 1366 <211> 19 <212> RNA <213> Homo sapiens <400> 1366 gcugcuuugg aucucuguc 19 <210> 1367 <211> 19 <212> RNA <213> Homo sapiens <400> 1367 cugcuuugga ucucugucc 19 <210> 1368 <211> 19 <212> RNA <213> Homo sapiens <400> 1368 ugcuuuggau cucuguccu 19 <210> 1369 <211> 19 <212> RNA <213> Homo sapiens <400> 1369 gcuuuggauc ucuguccuc 19 <210> 1370 <211> 19 <212> RNA <213> Homo sapiens <400> 1370 cuuuggaucu cuguccuca 19 <210> 1371 <211> 19 <212> RNA <213> Homo sapiens <400> 1371 uuuggaucuc uguccucac 19 <210> 1372 <211> 19 <212> RNA <213> Homo sapiens <400> 1372 ggaucucugu ccucaccag 19 <210> 1373 <211> 19 <212> RNA <213> Homo sapiens <400> 1373 gaucucuguc cucaccagc 19 <210> 1374 <211> 19 <212> RNA <213> Homo sapiens <400> 1374 cucuguccuc accagccuc 19 <210> 1375 <211> 19 <212> RNA <213> Homo sapiens <400> 1375 cuguccucac cagccuccu 19 <210> 1376 <211> 19 <212> RNA <213> Homo sapiens <400> 1376 uguccucacc agccuccug 19 <210> 1377 <211> 19 <212> RNA <213> Homo sapiens <400> 1377 guccucacca gccuccugg 19 <210> 1378 <211> 19 <212> RNA <213> Homo sapiens <400> 1378 uccucaccag ccuccugga 19 <210> 1379 <211> 19 <212> RNA <213> Homo sapiens <400> 1379 cucaccagcc uccuggaag 19 <210> 1380 <211> 19 <212> RNA <213> Homo sapiens <400> 1380 ucaccagccu ccuggaagc 19 <210> 1381 <211> 19 <212> RNA <213> Homo sapiens <400> 1381 accagccucc uggaagccu 19 <210> 1382 <211> 19 <212> RNA <213> Homo sapiens <400> 1382 ccagccuccu ggaagccuu 19 <210> 1383 <211> 19 <212> RNA <213> Homo sapiens <400> 1383 cagccuccug gaagccuuu 19 <210> 1384 <211> 19 <212> RNA <213> Homo sapiens <400> 1384 agccuccugg aagccuuug 19 <210> 1385 <211> 19 <212> RNA <213> Homo sapiens <400> 1385 gccuccugga agccuuugc 19 <210> 1386 <211> 19 <212> RNA <213> Homo sapiens <400> 1386 ccuccuggaa gccuuugcu 19 <210> 1387 <211> 19 <212> RNA <213> Homo sapiens <400> 1387 cuccuggaag ccuuugcuc 19 <210> 1388 <211> 19 <212> RNA <213> Homo sapiens <400> 1388 uccuggaagc cuuugcuca 19 <210> 1389 <211> 19 <212> RNA <213> Homo sapiens <400> 1389 ccuggaagcc uuugcucac 19 <210> 1390 <211> 19 <212> RNA <213> Homo sapiens <400> 1390 cuggaagccu uugcucaca 19 <210> 1391 <211> 19 <212> RNA <213> Homo sapiens <400> 1391 ggaagccuuu gcucacaca 19 <210> 1392 <211> 19 <212> RNA <213> Homo sapiens <400> 1392 gaagccuuug cucacacag 19 <210> 1393 <211> 19 <212> RNA <213> Homo sapiens <400> 1393 aagccuuugc ucacacaga 19 <210> 1394 <211> 19 <212> RNA <213> Homo sapiens <400> 1394 agccuuugcu cacacagac 19 <210> 1395 <211> 19 <212> RNA <213> Homo sapiens <400> 1395 gccuuugcuc acacagacc 19 <210> 1396 <211> 19 <212> RNA <213> Homo sapiens <400> 1396 ccuuugcuca cacagaccu 19 <210> 1397 <211> 19 <212> RNA <213> Homo sapiens <400> 1397 cuuugcucac acagaccuc 19 <210> 1398 <211> 19 <212> RNA <213> Homo sapiens <400> 1398 uuugcucaca cagaccuca 19 <210> 1399 <211> 19 <212> RNA <213> Homo sapiens <400> 1399 ugcucacaca gaccucagu 19 <210> 1400 <211> 19 <212> RNA <213> Homo sapiens <400> 1400 cucacacaga ccucagugg 19 <210> 1401 <211> 19 <212> RNA <213> Homo sapiens <400> 1401 cacacagacc ucaguggga 19 <210> 1402 <211> 19 <212> RNA <213> Homo sapiens <400> 1402 acacagaccu cagugggaa 19 <210> 1403 <211> 19 <212> RNA <213> Homo sapiens <400> 1403 cacagaccuc agugggaag 19 <210> 1404 <211> 19 <212> RNA <213> Homo sapiens <400> 1404 agaccucagu gggaaggug 19 <210> 1405 <211> 19 <212> RNA <213> Homo sapiens <400> 1405 gaccucagug ggaaggugu 19 <210> 1406 <211> 19 <212> RNA <213> Homo sapiens <400> 1406 accucagugg gaagguguu 19 <210> 1407 <211> 19 <212> RNA <213> Homo sapiens <400> 1407 ccucaguggg aagguguuu 19 <210> 1408 <211> 19 <212> RNA <213> Homo sapiens <400> 1408 cucaguggga agguguuug 19 <210> 1409 <211> 19 <212> RNA <213> Homo sapiens <400> 1409 ucagugggaa gguguuugu 19 <210> 1410 <211> 19 <212> RNA <213> Homo sapiens <400> 1410 cagugggaag guguuugua 19 <210> 1411 <211> 19 <212> RNA <213> Homo sapiens <400> 1411 agugggaagg uguuuguau 19 <210> 1412 <211> 19 <212> RNA <213> Homo sapiens <400> 1412 gugggaaggu guuuguauu 19 <210> 1413 <211> 19 <212> RNA <213> Homo sapiens <400> 1413 ugggaaggug uuuguauuu 19 <210> 1414 <211> 19 <212> RNA <213> Homo sapiens <400> 1414 gggaaggugu uuguauuuc 19 <210> 1415 <211> 19 <212> RNA <213> Homo sapiens <400> 1415 ggaagguguu uguauuucc 19 <210> 1416 <211> 19 <212> RNA <213> Homo sapiens <400> 1416 gaagguguuu guauuuccu 19 <210> 1417 <211> 19 <212> RNA <213> Homo sapiens <400> 1417 aagguguuug uauuuccua 19 <210> 1418 <211> 19 <212> RNA <213> Homo sapiens <400> 1418 agguguuugu auuuccuag 19 <210> 1419 <211> 19 <212> RNA <213> Homo sapiens <400> 1419 gguguuugua uuuccuaga 19 <210> 1420 <211> 19 <212> RNA <213> Homo sapiens <400> 1420 guguuuguau uuccuagag 19 <210> 1421 <211> 19 <212> RNA <213> Homo sapiens <400> 1421 uguuuguauu uccuagaga 19 <210> 1422 <211> 19 <212> RNA <213> Homo sapiens <400> 1422 guuuguauuu ccuagagaa 19 <210> 1423 <211> 19 <212> RNA <213> Homo sapiens <400> 1423 uuuguauuuc cuagagaau 19 <210> 1424 <211> 19 <212> RNA <213> Homo sapiens <400> 1424 uuguauuucc uagagaauc 19 <210> 1425 <211> 19 <212> RNA <213> Homo sapiens <400> 1425 uguauuuccu agagaaucu 19 <210> 1426 <211> 19 <212> RNA <213> Homo sapiens <400> 1426 guauuuccua gagaaucug 19 <210> 1427 <211> 19 <212> RNA <213> Homo sapiens <400> 1427 uauuuccuag agaaucugu 19 <210> 1428 <211> 19 <212> RNA <213> Homo sapiens <400> 1428 auuuccuaga gaaucuguu 19 <210> 1429 <211> 19 <212> RNA <213> Homo sapiens <400> 1429 uuuccuagag aaucuguua 19 <210> 1430 <211> 19 <212> RNA <213> Homo sapiens <400> 1430 uccuagagaa ucuguuacu 19 <210> 1431 <211> 19 <212> RNA <213> Homo sapiens <400> 1431 ccuagagaau cuguuacug 19 <210> 1432 <211> 19 <212> RNA <213> Homo sapiens <400> 1432 cuagagaauc uguuacuga 19 <210> 1433 <211> 19 <212> RNA <213> Homo sapiens <400> 1433 uagagaaucu guuacugau 19 <210> 1434 <211> 19 <212> RNA <213> Homo sapiens <400> 1434 agagaaucug uuacugauc 19 <210> 1435 <211> 19 <212> RNA <213> Homo sapiens <400> 1435 gagaaucugu uacugauca 19 <210> 1436 <211> 19 <212> RNA <213> Homo sapiens <400> 1436 agaaucuguu acugaucau 19 <210> 1437 <211> 19 <212> RNA <213> Homo sapiens <400> 1437 gaaucuguua cugaucaug 19 <210> 1438 <211> 19 <212> RNA <213> Homo sapiens <400> 1438 aaucuguuac ugaucaugu 19 <210> 1439 <211> 19 <212> RNA <213> Homo sapiens <400> 1439 aucuguuacu gaucaugua 19 <210> 1440 <211> 19 <212> RNA <213> Homo sapiens <400> 1440 ucuguuacug aucauguaa 19 <210> 1441 <211> 19 <212> RNA <213> Homo sapiens <400> 1441 cuguuacuga ucauguaaa 19 <210> 1442 <211> 19 <212> RNA <213> Homo sapiens <400> 1442 uguuacugau cauguaaac 19 <210> 1443 <211> 19 <212> RNA <213> Homo sapiens <400> 1443 guuacugauc auguaaacu 19 <210> 1444 <211> 19 <212> RNA <213> Homo sapiens <400> 1444 acugaucaug uaaacuuga 19 <210> 1445 <211> 19 <212> RNA <213> Homo sapiens <400> 1445 cugaucaugu aaacuugau 19 <210> 1446 <211> 19 <212> RNA <213> Homo sapiens <400> 1446 ugaucaugua aacuugauc 19 <210> 1447 <211> 19 <212> RNA <213> Homo sapiens <400> 1447 gaucauguaa acuugauca 19 <210> 1448 <211> 19 <212> RNA <213> Homo sapiens <400> 1448 ucauguaaac uugaucaca 19 <210> 1449 <211> 19 <212> RNA <213> Homo sapiens <400> 1449 cauguaaacu ugaucacac 19 <210> 1450 <211> 19 <212> RNA <213> Homo sapiens <400> 1450 uaaacuugau cacaccgcu 19 <210> 1451 <211> 19 <212> RNA <213> Homo sapiens <400> 1451 aaacuugauc acaccgcug 19 <210> 1452 <211> 19 <212> RNA <213> Homo sapiens <400> 1452 acuugaucac accgcugga 19 <210> 1453 <211> 19 <212> RNA <213> Homo sapiens <400> 1453 uugaucacac cgcuggaga 19 <210> 1454 <211> 19 <212> RNA <213> Homo sapiens <400> 1454 ugaucacacc gcuggagaa 19 <210> 1455 <211> 19 <212> RNA <213> Homo sapiens <400> 1455 gaucacaccg cuggagaag 19 <210> 1456 <211> 19 <212> RNA <213> Homo sapiens <400> 1456 cacaccgcug gagaagccu 19 <210> 1457 <211> 19 <212> RNA <213> Homo sapiens <400> 1457 acaccgcugg agaagccuc 19 <210> 1458 <211> 19 <212> RNA <213> Homo sapiens <400> 1458 caccgcugga gaagccucu 19 <210> 1459 <211> 19 <212> RNA <213> Homo sapiens <400> 1459 accgcuggag aagccucua 19 <210> 1460 <211> 19 <212> RNA <213> Homo sapiens <400> 1460 ccgcuggaga agccucuac 19 <210> 1461 <211> 19 <212> RNA <213> Homo sapiens <400> 1461 cgcuggagaa gccucuaca 19 <210> 1462 <211> 19 <212> RNA <213> Homo sapiens <400> 1462 gcuggagaag ccucuacag 19 <210> 1463 <211> 19 <212> RNA <213> Homo sapiens <400> 1463 cuggagaagc cucuacaga 19 <210> 1464 <211> 19 <212> RNA <213> Homo sapiens <400> 1464 uggagaagcc ucuacagaa 19 <210> 1465 <211> 19 <212> RNA <213> Homo sapiens <400> 1465 ggagaagccu cuacagaac 19 <210> 1466 <211> 19 <212> RNA <213> Homo sapiens <400> 1466 gagaagccuc uacagaacu 19 <210> 1467 <211> 19 <212> RNA <213> Homo sapiens <400> 1467 agaagccucu acagaacuu 19 <210> 1468 <211> 19 <212> RNA <213> Homo sapiens <400> 1468 gaagccucua cagaacuuu 19 <210> 1469 <211> 19 <212> RNA <213> Homo sapiens <400> 1469 aagccucuac agaacuuua 19 <210> 1470 <211> 19 <212> RNA <213> Homo sapiens <400> 1470 agccucuaca gaacuuuac 19 <210> 1471 <211> 19 <212> RNA <213> Homo sapiens <400> 1471 gccucuacag aacuuuacc 19 <210> 1472 <211> 19 <212> RNA <213> Homo sapiens <400> 1472 ccucuacaga acuuuaccu 19 <210> 1473 <211> 19 <212> RNA <213> Homo sapiens <400> 1473 cucuacagaa cuuuaccuu 19 <210> 1474 <211> 19 <212> RNA <213> Homo sapiens <400> 1474 ucuacagaac uuuaccuug 19 <210> 1475 <211> 19 <212> RNA <213> Homo sapiens <400> 1475 cuacagaacu uuaccuugu 19 <210> 1476 <211> 19 <212> RNA <213> Homo sapiens <400> 1476 uacagaacuu uaccuugug 19 <210> 1477 <211> 19 <212> RNA <213> Homo sapiens <400> 1477 acagaacuuu accuugugu 19 <210> 1478 <211> 19 <212> RNA <213> Homo sapiens <400> 1478 cagaacuuua ccuuguguu 19 <210> 1479 <211> 19 <212> RNA <213> Homo sapiens <400> 1479 agaacuuuac cuuguguuu 19 <210> 1480 <211> 19 <212> RNA <213> Homo sapiens <400> 1480 gaacuuuacc uuguguuuu 19 <210> 1481 <211> 19 <212> RNA <213> Homo sapiens <400> 1481 aacuuuaccu uguguuuuc 19 <210> 1482 <211> 19 <212> RNA <213> Homo sapiens <400> 1482 cuuuaccuug uguuuucga 19 <210> 1483 <211> 19 <212> RNA <213> Homo sapiens <400> 1483 accuuguguu uucgagccu 19 <210> 1484 <211> 19 <212> RNA <213> Homo sapiens <400> 1484 ccuuguguuu ucgagccua 19 <210> 1485 <211> 19 <212> RNA <213> Homo sapiens <400> 1485 cuuguguuuu cgagccuau 19 <210> 1486 <211> 19 <212> RNA <213> Homo sapiens <400> 1486 uuguguuuuc gagccuaua 19 <210> 1487 <211> 19 <212> RNA <213> Homo sapiens <400> 1487 guguuuucga gccuauagu 19 <210> 1488 <211> 19 <212> RNA <213> Homo sapiens <400> 1488 guuuucgagc cuauaguga 19 <210> 1489 <211> 19 <212> RNA <213> Homo sapiens <400> 1489 uuuucgagcc uauagugau 19 <210> 1490 <211> 19 <212> RNA <213> Homo sapiens <400> 1490 cgagccuaua gugaucucu 19 <210> 1491 <211> 19 <212> RNA <213> Homo sapiens <400> 1491 gagccuauag ugaucucuc 19 <210> 1492 <211> 19 <212> RNA <213> Homo sapiens <400> 1492 agccuauagu gaucucucu 19 <210> 1493 <211> 19 <212> RNA <213> Homo sapiens <400> 1493 gccuauagug aucucucuc 19 <210> 1494 <211> 19 <212> RNA <213> Homo sapiens <400> 1494 ccuauaguga ucucucucg 19 <210> 1495 <211> 19 <212> RNA <213> Homo sapiens <400> 1495 cuauagugau cucucucgu 19 <210> 1496 <211> 19 <212> RNA <213> Homo sapiens <400> 1496 uauagugauc ucucucgug 19 <210> 1497 <211> 19 <212> RNA <213> Homo sapiens <400> 1497 agugaucucu cucgugccu 19 <210> 1498 <211> 19 <212> RNA <213> Homo sapiens <400> 1498 gugaucucuc ucgugccua 19 <210> 1499 <211> 19 <212> RNA <213> Homo sapiens <400> 1499 ugaucucucu cgugccuac 19 <210> 1500 <211> 19 <212> RNA <213> Homo sapiens <400> 1500 gaucucucuc gugccuaca 19 <210> 1501 <211> 19 <212> RNA <213> Homo sapiens <400> 1501 cucucgugcc uacagccuc 19 <210> 1502 <211> 19 <212> RNA <213> Homo sapiens <400> 1502 ucucgugccu acagccucu 19 <210> 1503 <211> 19 <212> RNA <213> Homo sapiens <400> 1503 cucgugccua cagccucuu 19 <210> 1504 <211> 19 <212> RNA <213> Homo sapiens <400> 1504 cgugccuaca gccucuucu 19 <210> 1505 <211> 19 <212> RNA <213> Homo sapiens <400> 1505 gugccuacag ccucuucuc 19 <210> 1506 <211> 19 <212> RNA <213> Homo sapiens <400> 1506 gccuacagcc ucuucuccu 19 <210> 1507 <211> 19 <212> RNA <213> Homo sapiens <400> 1507 ccuacagccu cuucuccua 19 <210> 1508 <211> 19 <212> RNA <213> Homo sapiens <400> 1508 cuacagccuc uucuccuac 19 <210> 1509 <211> 19 <212> RNA <213> Homo sapiens <400> 1509 uacagccucu ucuccuaca 19 <210> 1510 <211> 19 <212> RNA <213> Homo sapiens <400> 1510 acagccucuu cuccuacaa 19 <210> 1511 <211> 19 <212> RNA <213> Homo sapiens <400> 1511 cagccucuuc uccuacaau 19 <210> 1512 <211> 19 <212> RNA <213> Homo sapiens <400> 1512 agccucuucu ccuacaaua 19 <210> 1513 <211> 19 <212> RNA <213> Homo sapiens <400> 1513 gccucuucuc cuacaauac 19 <210> 1514 <211> 19 <212> RNA <213> Homo sapiens <400> 1514 ccucuucucc uacaauacc 19 <210> 1515 <211> 19 <212> RNA <213> Homo sapiens <400> 1515 ucuucuccua caauaccca 19 <210> 1516 <211> 19 <212> RNA <213> Homo sapiens <400> 1516 ucuccuacaa uacccaagg 19 <210> 1517 <211> 19 <212> RNA <213> Homo sapiens <400> 1517 cuccuacaau acccaaggc 19 <210> 1518 <211> 19 <212> RNA <213> Homo sapiens <400> 1518 uccuacaaua cccaaggca 19 <210> 1519 <211> 19 <212> RNA <213> Homo sapiens <400> 1519 ccuacaauac ccaaggcag 19 <210> 1520 <211> 19 <212> RNA <213> Homo sapiens <400> 1520 cuacaauacc caaggcagg 19 <210> 1521 <211> 19 <212> RNA <213> Homo sapiens <400> 1521 caauacccaa ggcagggau 19 <210> 1522 <211> 19 <212> RNA <213> Homo sapiens <400> 1522 auacccaagg cagggauaa 19 <210> 1523 <211> 19 <212> RNA <213> Homo sapiens <400> 1523 uacccaaggc agggauaau 19 <210> 1524 <211> 19 <212> RNA <213> Homo sapiens <400> 1524 ccaaggcagg gauaaugag 19 <210> 1525 <211> 19 <212> RNA <213> Homo sapiens <400> 1525 aaggcaggga uaaugagcu 19 <210> 1526 <211> 19 <212> RNA <213> Homo sapiens <400> 1526 aggcagggau aaugagcua 19 <210> 1527 <211> 19 <212> RNA <213> Homo sapiens <400> 1527 gcagggauaa ugagcuacu 19 <210> 1528 <211> 19 <212> RNA <213> Homo sapiens <400> 1528 cagggauaau gagcuacua 19 <210> 1529 <211> 19 <212> RNA <213> Homo sapiens <400> 1529 agggauaaug agcuacuag 19 <210> 1530 <211> 19 <212> RNA <213> Homo sapiens <400> 1530 gggauaauga gcuacuagu 19 <210> 1531 <211> 19 <212> RNA <213> Homo sapiens <400> 1531 ggauaaugag cuacuaguu 19 <210> 1532 <211> 19 <212> RNA <213> Homo sapiens <400> 1532 gauaaugagc uacuaguuu 19 <210> 1533 <211> 19 <212> RNA <213> Homo sapiens <400> 1533 auaaugagcu acuaguuua 19 <210> 1534 <211> 19 <212> RNA <213> Homo sapiens <400> 1534 uaaugagcua cuaguuuau 19 <210> 1535 <211> 19 <212> RNA <213> Homo sapiens <400> 1535 augagcuacu aguuuauaa 19 <210> 1536 <211> 19 <212> RNA <213> Homo sapiens <400> 1536 ugagcuacua guuuauaaa 19 <210> 1537 <211> 19 <212> RNA <213> Homo sapiens <400> 1537 gagcuacuag uuuauaaag 19 <210> 1538 <211> 19 <212> RNA <213> Homo sapiens <400> 1538 agcuacuagu uuauaaaga 19 <210> 1539 <211> 19 <212> RNA <213> Homo sapiens <400> 1539 gcuacuaguu uauaaagaa 19 <210> 1540 <211> 19 <212> RNA <213> Homo sapiens <400> 1540 cuacuaguuu auaaagaaa 19 <210> 1541 <211> 19 <212> RNA <213> Homo sapiens <400> 1541 aguuuauaaa gaaagaguu 19 <210> 1542 <211> 19 <212> RNA <213> Homo sapiens <400> 1542 aagaaagagu uggagagua 19 <210> 1543 <211> 19 <212> RNA <213> Homo sapiens <400> 1543 agaaagaguu ggagaguau 19 <210> 1544 <211> 19 <212> RNA <213> Homo sapiens <400> 1544 gaaagaguug gagaguaua 19 <210> 1545 <211> 19 <212> RNA <213> Homo sapiens <400> 1545 aagaguugga gaguauagu 19 <210> 1546 <211> 19 <212> RNA <213> Homo sapiens <400> 1546 agaguuggag aguauaguc 19 <210> 1547 <211> 19 <212> RNA <213> Homo sapiens <400> 1547 gaguuggaga guauagucu 19 <210> 1548 <211> 19 <212> RNA <213> Homo sapiens <400> 1548 aguuggagag uauagucua 19 <210> 1549 <211> 19 <212> RNA <213> Homo sapiens <400> 1549 guuggagagu auagucuau 19 <210> 1550 <211> 19 <212> RNA <213> Homo sapiens <400> 1550 uuggagagua uagucuaua 19 <210> 1551 <211> 19 <212> RNA <213> Homo sapiens <400> 1551 uggagaguau agucuauac 19 <210> 1552 <211> 19 <212> RNA <213> Homo sapiens <400> 1552 ggagaguaua gucuauaca 19 <210> 1553 <211> 19 <212> RNA <213> Homo sapiens <400> 1553 gagaguauag ucuauacau 19 <210> 1554 <211> 19 <212> RNA <213> Homo sapiens <400> 1554 agaguauagu cuauacauu 19 <210> 1555 <211> 19 <212> RNA <213> Homo sapiens <400> 1555 gaguauaguc uauacauug 19 <210> 1556 <211> 19 <212> RNA <213> Homo sapiens <400> 1556 aguauagucu auacauugg 19 <210> 1557 <211> 19 <212> RNA <213> Homo sapiens <400> 1557 guauagucua uacauugga 19 <210> 1558 <211> 19 <212> RNA <213> Homo sapiens <400> 1558 gucuauacau uggaagaca 19 <210> 1559 <211> 19 <212> RNA <213> Homo sapiens <400> 1559 cuauacauug gaagacaca 19 <210> 1560 <211> 19 <212> RNA <213> Homo sapiens <400> 1560 uauacauugg aagacacaa 19 <210> 1561 <211> 19 <212> RNA <213> Homo sapiens <400> 1561 auacauugga agacacaaa 19 <210> 1562 <211> 19 <212> RNA <213> Homo sapiens <400> 1562 acauuggaag acacaaagu 19 <210> 1563 <211> 19 <212> RNA <213> Homo sapiens <400> 1563 cauuggaaga cacaaaguu 19 <210> 1564 <211> 19 <212> RNA <213> Homo sapiens <400> 1564 auuggaagac acaaaguua 19 <210> 1565 <211> 19 <212> RNA <213> Homo sapiens <400> 1565 uggaagacac aaaguuaca 19 <210> 1566 <211> 19 <212> RNA <213> Homo sapiens <400> 1566 ggaagacaca aaguuacau 19 <210> 1567 <211> 19 <212> RNA <213> Homo sapiens <400> 1567 gaagacacaa aguuacauc 19 <210> 1568 <211> 19 <212> RNA <213> Homo sapiens <400> 1568 aagacacaaa guuacaucc 19 <210> 1569 <211> 19 <212> RNA <213> Homo sapiens <400> 1569 agacacaaag uuacaucca 19 <210> 1570 <211> 19 <212> RNA <213> Homo sapiens <400> 1570 gacacaaagu uacauccaa 19 <210> 1571 <211> 19 <212> RNA <213> Homo sapiens <400> 1571 acacaaaguu acauccaaa 19 <210> 1572 <211> 19 <212> RNA <213> Homo sapiens <400> 1572 cacaaaguua cauccaaag 19 <210> 1573 <211> 19 <212> RNA <213> Homo sapiens <400> 1573 caaaguuaca uccaaaguu 19 <210> 1574 <211> 19 <212> RNA <213> Homo sapiens <400> 1574 aaaguuacau ccaaaguua 19 <210> 1575 <211> 19 <212> RNA <213> Homo sapiens <400> 1575 aaguuacauc caaaguuau 19 <210> 1576 <211> 19 <212> RNA <213> Homo sapiens <400> 1576 aguuacaucc aaaguuauc 19 <210> 1577 <211> 19 <212> RNA <213> Homo sapiens <400> 1577 guuacaucca aaguuaucg 19 <210> 1578 <211> 19 <212> RNA <213> Homo sapiens <400> 1578 uuacauccaa aguuaucga 19 <210> 1579 <211> 19 <212> RNA <213> Homo sapiens <400> 1579 uacauccaaa guuaucgaa 19 <210> 1580 <211> 19 <212> RNA <213> Homo sapiens <400> 1580 acauccaaag uuaucgaaa 19 <210> 1581 <211> 19 <212> RNA <213> Homo sapiens <400> 1581 cauccaaagu uaucgaaaa 19 <210> 1582 <211> 19 <212> RNA <213> Homo sapiens <400> 1582 auccaaaguu aucgaaaag 19 <210> 1583 <211> 19 <212> RNA <213> Homo sapiens <400> 1583 uccaaaguua ucgaaaagu 19 <210> 1584 <211> 19 <212> RNA <213> Homo sapiens <400> 1584 ccaaaguuau cgaaaaguu 19 <210> 1585 <211> 19 <212> RNA <213> Homo sapiens <400> 1585 caaaguuauc gaaaaguuc 19 <210> 1586 <211> 19 <212> RNA <213> Homo sapiens <400> 1586 cgaaaaguuc ccggcucca 19 <210> 1587 <211> 19 <212> RNA <213> Homo sapiens <400> 1587 aaaaguuccc ggcuccagu 19 <210> 1588 <211> 19 <212> RNA <213> Homo sapiens <400> 1588 cccggcucca gugcacauc 19 <210> 1589 <211> 19 <212> RNA <213> Homo sapiens <400> 1589 cggcuccagu gcacaucug 19 <210> 1590 <211> 19 <212> RNA <213> Homo sapiens <400> 1590 ggcuccagug cacaucugu 19 <210> 1591 <211> 19 <212> RNA <213> Homo sapiens <400> 1591 gcuccagugc acaucugug 19 <210> 1592 <211> 19 <212> RNA <213> Homo sapiens <400> 1592 cuccagugca caucugugu 19 <210> 1593 <211> 19 <212> RNA <213> Homo sapiens <400> 1593 ccagugcaca ucuguguga 19 <210> 1594 <211> 19 <212> RNA <213> Homo sapiens <400> 1594 gugcacaucu gugugagcu 19 <210> 1595 <211> 19 <212> RNA <213> Homo sapiens <400> 1595 gcacaucugu gugagcugg 19 <210> 1596 <211> 19 <212> RNA <213> Homo sapiens <400> 1596 acaucugugu gagcuggga 19 <210> 1597 <211> 19 <212> RNA <213> Homo sapiens <400> 1597 aucuguguga gcugggagu 19 <210> 1598 <211> 19 <212> RNA <213> Homo sapiens <400> 1598 ugugugagcu gggaguccu 19 <210> 1599 <211> 19 <212> RNA <213> Homo sapiens <400> 1599 gugugagcug ggaguccuc 19 <210> 1600 <211> 19 <212> RNA <213> Homo sapiens <400> 1600 agcugggagu ccucaucag 19 <210> 1601 <211> 19 <212> RNA <213> Homo sapiens <400> 1601 gcugggaguc cucaucagg 19 <210> 1602 <211> 19 <212> RNA <213> Homo sapiens <400> 1602 cugggagucc ucaucaggu 19 <210> 1603 <211> 19 <212> RNA <213> Homo sapiens <400> 1603 ugggaguccu caucaggua 19 <210> 1604 <211> 19 <212> RNA <213> Homo sapiens <400> 1604 gggaguccuc aucagguau 19 <210> 1605 <211> 19 <212> RNA <213> Homo sapiens <400> 1605 ggaguccuca ucagguauu 19 <210> 1606 <211> 19 <212> RNA <213> Homo sapiens <400> 1606 gaguccucau cagguauug 19 <210> 1607 <211> 19 <212> RNA <213> Homo sapiens <400> 1607 guccucauca gguauugcu 19 <210> 1608 <211> 19 <212> RNA <213> Homo sapiens <400> 1608 uccucaucag guauugcug 19 <210> 1609 <211> 19 <212> RNA <213> Homo sapiens <400> 1609 ccucaucagg uauugcuga 19 <210> 1610 <211> 19 <212> RNA <213> Homo sapiens <400> 1610 cucaucaggu auugcugaa 19 <210> 1611 <211> 19 <212> RNA <213> Homo sapiens <400> 1611 ucaucaggua uugcugaau 19 <210> 1612 <211> 19 <212> RNA <213> Homo sapiens <400> 1612 caucagguau ugcugaauu 19 <210> 1613 <211> 19 <212> RNA <213> Homo sapiens <400> 1613 aucagguauu gcugaauuu 19 <210> 1614 <211> 19 <212> RNA <213> Homo sapiens <400> 1614 ucagguauug cugaauuuu 19 <210> 1615 <211> 19 <212> RNA <213> Homo sapiens <400> 1615 cagguauugc ugaauuuug 19 <210> 1616 <211> 19 <212> RNA <213> Homo sapiens <400> 1616 agguauugcu gaauuuugg 19 <210> 1617 <211> 19 <212> RNA <213> Homo sapiens <400> 1617 gguauugcug aauuuugga 19 <210> 1618 <211> 19 <212> RNA <213> Homo sapiens <400> 1618 guauugcuga auuuuggau 19 <210> 1619 <211> 19 <212> RNA <213> Homo sapiens <400> 1619 auugcugaau uuuggauca 19 <210> 1620 <211> 19 <212> RNA <213> Homo sapiens <400> 1620 ugcugaauuu uggaucaau 19 <210> 1621 <211> 19 <212> RNA <213> Homo sapiens <400> 1621 gcugaauuuu ggaucaaug 19 <210> 1622 <211> 19 <212> RNA <213> Homo sapiens <400> 1622 cugaauuuug gaucaaugg 19 <210> 1623 <211> 19 <212> RNA <213> Homo sapiens <400> 1623 gaauuuugga ucaauggga 19 <210> 1624 <211> 19 <212> RNA <213> Homo sapiens <400> 1624 ggaucaaugg gacaccuuu 19 <210> 1625 <211> 19 <212> RNA <213> Homo sapiens <400> 1625 caaugggaca ccuuuggug 19 <210> 1626 <211> 19 <212> RNA <213> Homo sapiens <400> 1626 aaugggacac cuuugguga 19 <210> 1627 <211> 19 <212> RNA <213> Homo sapiens <400> 1627 augggacacc uuuggugaa 19 <210> 1628 <211> 19 <212> RNA <213> Homo sapiens <400> 1628 ugggacaccu uuggugaaa 19 <210> 1629 <211> 19 <212> RNA <213> Homo sapiens <400> 1629 gggacaccuu uggugaaaa 19 <210> 1630 <211> 19 <212> RNA <213> Homo sapiens <400> 1630 ggacaccuuu ggugaaaaa 19 <210> 1631 <211> 19 <212> RNA <213> Homo sapiens <400> 1631 accuuuggug aaaaagggu 19 <210> 1632 <211> 19 <212> RNA <213> Homo sapiens <400> 1632 ccuuugguga aaaaggguc 19 <210> 1633 <211> 19 <212> RNA <213> Homo sapiens <400> 1633 cuuuggugaa aaagggucu 19 <210> 1634 <211> 19 <212> RNA <213> Homo sapiens <400> 1634 ggugaaaaag ggucugcga 19 <210> 1635 <211> 19 <212> RNA <213> Homo sapiens <400> 1635 gugaaaaagg gucugcgac 19 <210> 1636 <211> 19 <212> RNA <213> Homo sapiens <400> 1636 ugaaaaaggg ucugcgaca 19 <210> 1637 <211> 19 <212> RNA <213> Homo sapiens <400> 1637 gaaaaagggu cugcgacag 19 <210> 1638 <211> 19 <212> RNA <213> Homo sapiens <400> 1638 aaagggucug cgacagggu 19 <210> 1639 <211> 19 <212> RNA <213> Homo sapiens <400> 1639 aagggucugc gacaggguu 19 <210> 1640 <211> 19 <212> RNA <213> Homo sapiens <400> 1640 agggucugcg acaggguua 19 <210> 1641 <211> 19 <212> RNA <213> Homo sapiens <400> 1641 gggucugcga caggguuac 19 <210> 1642 <211> 19 <212> RNA <213> Homo sapiens <400> 1642 ggucugcgac aggguuacu 19 <210> 1643 <211> 19 <212> RNA <213> Homo sapiens <400> 1643 gucugcgaca ggguuacuu 19 <210> 1644 <211> 19 <212> RNA <213> Homo sapiens <400> 1644 ucugcgacag gguuacuuu 19 <210> 1645 <211> 19 <212> RNA <213> Homo sapiens <400> 1645 cugcgacagg guuacuuug 19 <210> 1646 <211> 19 <212> RNA <213> Homo sapiens <400> 1646 ugcgacaggg uuacuuugu 19 <210> 1647 <211> 19 <212> RNA <213> Homo sapiens <400> 1647 gcgacagggu uacuuugua 19 <210> 1648 <211> 19 <212> RNA <213> Homo sapiens <400> 1648 cgacaggguu acuuuguag 19 <210> 1649 <211> 19 <212> RNA <213> Homo sapiens <400> 1649 gacaggguua cuuuguaga 19 <210> 1650 <211> 19 <212> RNA <213> Homo sapiens <400> 1650 acaggguuac uuuguagaa 19 <210> 1651 <211> 19 <212> RNA <213> Homo sapiens <400> 1651 caggguuacu uuguagaag 19 <210> 1652 <211> 19 <212> RNA <213> Homo sapiens <400> 1652 aggguuacuu uguagaagc 19 <210> 1653 <211> 19 <212> RNA <213> Homo sapiens <400> 1653 ggguuacuuu guagaagcu 19 <210> 1654 <211> 19 <212> RNA <213> Homo sapiens <400> 1654 gguuacuuug uagaagcuc 19 <210> 1655 <211> 19 <212> RNA <213> Homo sapiens <400> 1655 guuacuuugu agaagcuca 19 <210> 1656 <211> 19 <212> RNA <213> Homo sapiens <400> 1656 agaagcucag cccaagauu 19 <210> 1657 <211> 19 <212> RNA <213> Homo sapiens <400> 1657 gaagcucagc ccaagauug 19 <210> 1658 <211> 19 <212> RNA <213> Homo sapiens <400> 1658 aagcucagcc caagauugu 19 <210> 1659 <211> 19 <212> RNA <213> Homo sapiens <400> 1659 agcucagccc aagauuguc 19 <210> 1660 <211> 19 <212> RNA <213> Homo sapiens <400> 1660 cucagcccaa gauuguccu 19 <210> 1661 <211> 19 <212> RNA <213> Homo sapiens <400> 1661 agcccaagau uguccuggg 19 <210> 1662 <211> 19 <212> RNA <213> Homo sapiens <400> 1662 ccaagauugu ccuggggca 19 <210> 1663 <211> 19 <212> RNA <213> Homo sapiens <400> 1663 caagauuguc cuggggcag 19 <210> 1664 <211> 19 <212> RNA <213> Homo sapiens <400> 1664 agauuguccu ggggcagga 19 <210> 1665 <211> 19 <212> RNA <213> Homo sapiens <400> 1665 gauuguccug gggcaggaa 19 <210> 1666 <211> 19 <212> RNA <213> Homo sapiens <400> 1666 uuguccuggg gcaggaaca 19 <210> 1667 <211> 19 <212> RNA <213> Homo sapiens <400> 1667 uccuggggca ggaacagga 19 <210> 1668 <211> 19 <212> RNA <213> Homo sapiens <400> 1668 cuggggcagg aacaggauu 19 <210> 1669 <211> 19 <212> RNA <213> Homo sapiens <400> 1669 uggggcagga acaggauuc 19 <210> 1670 <211> 19 <212> RNA <213> Homo sapiens <400> 1670 ggggcaggaa caggauucc 19 <210> 1671 <211> 19 <212> RNA <213> Homo sapiens <400> 1671 ggcaggaaca ggauuccua 19 <210> 1672 <211> 19 <212> RNA <213> Homo sapiens <400> 1672 gcaggaacag gauuccuau 19 <210> 1673 <211> 19 <212> RNA <213> Homo sapiens <400> 1673 caggaacagg auuccuaug 19 <210> 1674 <211> 19 <212> RNA <213> Homo sapiens <400> 1674 ggaacaggau uccuauggg 19 <210> 1675 <211> 19 <212> RNA <213> Homo sapiens <400> 1675 gaacaggauu ccuaugggg 19 <210> 1676 <211> 19 <212> RNA <213> Homo sapiens <400> 1676 acaggauucc uaugggggc 19 <210> 1677 <211> 19 <212> RNA <213> Homo sapiens <400> 1677 caggauuccu augggggca 19 <210> 1678 <211> 19 <212> RNA <213> Homo sapiens <400> 1678 ggauuccuau gggggcaag 19 <210> 1679 <211> 19 <212> RNA <213> Homo sapiens <400> 1679 gauuccuaug ggggcaagu 19 <210> 1680 <211> 19 <212> RNA <213> Homo sapiens <400> 1680 auuccuaugg gggcaaguu 19 <210> 1681 <211> 19 <212> RNA <213> Homo sapiens <400> 1681 uuccuauggg ggcaaguuu 19 <210> 1682 <211> 19 <212> RNA <213> Homo sapiens <400> 1682 uccuaugggg gcaaguuug 19 <210> 1683 <211> 19 <212> RNA <213> Homo sapiens <400> 1683 ccuauggggg caaguuuga 19 <210> 1684 <211> 19 <212> RNA <213> Homo sapiens <400> 1684 cuaugggggc aaguuugau 19 <210> 1685 <211> 19 <212> RNA <213> Homo sapiens <400> 1685 uaugggggca aguuugaua 19 <210> 1686 <211> 19 <212> RNA <213> Homo sapiens <400> 1686 gggggcaagu uugauagga 19 <210> 1687 <211> 19 <212> RNA <213> Homo sapiens <400> 1687 ggggcaaguu ugauaggag 19 <210> 1688 <211> 19 <212> RNA <213> Homo sapiens <400> 1688 gggcaaguuu gauaggagc 19 <210> 1689 <211> 19 <212> RNA <213> Homo sapiens <400> 1689 ggcaaguuug auaggagcc 19 <210> 1690 <211> 19 <212> RNA <213> Homo sapiens <400> 1690 gcaaguuuga uaggagcca 19 <210> 1691 <211> 19 <212> RNA <213> Homo sapiens <400> 1691 caaguuugau aggagccag 19 <210> 1692 <211> 19 <212> RNA <213> Homo sapiens <400> 1692 aaguuugaua ggagccagu 19 <210> 1693 <211> 19 <212> RNA <213> Homo sapiens <400> 1693 uugauaggag ccaguccuu 19 <210> 1694 <211> 19 <212> RNA <213> Homo sapiens <400> 1694 ugauaggagc caguccuuu 19 <210> 1695 <211> 19 <212> RNA <213> Homo sapiens <400> 1695 gauaggagcc aguccuuug 19 <210> 1696 <211> 19 <212> RNA <213> Homo sapiens <400> 1696 auaggagcca guccuuugu 19 <210> 1697 <211> 19 <212> RNA <213> Homo sapiens <400> 1697 aggagccagu ccuuugugg 19 <210> 1698 <211> 19 <212> RNA <213> Homo sapiens <400> 1698 ggagccaguc cuuuguggg 19 <210> 1699 <211> 19 <212> RNA <213> Homo sapiens <400> 1699 gagccagucc uuuguggga 19 <210> 1700 <211> 19 <212> RNA <213> Homo sapiens <400> 1700 agccaguccu uugugggag 19 <210> 1701 <211> 19 <212> RNA <213> Homo sapiens <400> 1701 gccaguccuu ugugggaga 19 <210> 1702 <211> 19 <212> RNA <213> Homo sapiens <400> 1702 ccaguccuuu gugggagag 19 <210> 1703 <211> 19 <212> RNA <213> Homo sapiens <400> 1703 caguccuuug ugggagaga 19 <210> 1704 <211> 19 <212> RNA <213> Homo sapiens <400> 1704 aguccuuugu gggagagau 19 <210> 1705 <211> 19 <212> RNA <213> Homo sapiens <400> 1705 guccuuugug ggagagauu 19 <210> 1706 <211> 19 <212> RNA <213> Homo sapiens <400> 1706 uccuuugugg gagagauug 19 <210> 1707 <211> 19 <212> RNA <213> Homo sapiens <400> 1707 ccuuuguggg agagauugg 19 <210> 1708 <211> 19 <212> RNA <213> Homo sapiens <400> 1708 cuuuguggga gagauuggg 19 <210> 1709 <211> 19 <212> RNA <213> Homo sapiens <400> 1709 uugugggaga gauugggga 19 <210> 1710 <211> 19 <212> RNA <213> Homo sapiens <400> 1710 ugugggagag auuggggau 19 <210> 1711 <211> 19 <212> RNA <213> Homo sapiens <400> 1711 gugggagaga uuggggauu 19 <210> 1712 <211> 19 <212> RNA <213> Homo sapiens <400> 1712 ugggagagau uggggauuu 19 <210> 1713 <211> 19 <212> RNA <213> Homo sapiens <400> 1713 gggagagauu ggggauuug 19 <210> 1714 <211> 19 <212> RNA <213> Homo sapiens <400> 1714 ggagagauug gggauuugu 19 <210> 1715 <211> 19 <212> RNA <213> Homo sapiens <400> 1715 gagagauugg ggauuugua 19 <210> 1716 <211> 19 <212> RNA <213> Homo sapiens <400> 1716 agagauuggg gauuuguac 19 <210> 1717 <211> 19 <212> RNA <213> Homo sapiens <400> 1717 gagauugggg auuuguaca 19 <210> 1718 <211> 19 <212> RNA <213> Homo sapiens <400> 1718 agauugggga uuuguacau 19 <210> 1719 <211> 19 <212> RNA <213> Homo sapiens <400> 1719 ggggauuugu acauguggg 19 <210> 1720 <211> 19 <212> RNA <213> Homo sapiens <400> 1720 gggauuugua cauguggga 19 <210> 1721 <211> 19 <212> RNA <213> Homo sapiens <400> 1721 ggauuuguac augugggac 19 <210> 1722 <211> 19 <212> RNA <213> Homo sapiens <400> 1722 gauuuguaca ugugggacu 19 <210> 1723 <211> 19 <212> RNA <213> Homo sapiens <400> 1723 uguacaugug ggacucugu 19 <210> 1724 <211> 19 <212> RNA <213> Homo sapiens <400> 1724 guacaugugg gacucugug 19 <210> 1725 <211> 19 <212> RNA <213> Homo sapiens <400> 1725 acauguggga cucugugcu 19 <210> 1726 <211> 19 <212> RNA <213> Homo sapiens <400> 1726 gggacucugu gcugccccc 19 <210> 1727 <211> 19 <212> RNA <213> Homo sapiens <400> 1727 ggacucugug cugccccca 19 <210> 1728 <211> 19 <212> RNA <213> Homo sapiens <400> 1728 acucugugcu gcccccaga 19 <210> 1729 <211> 19 <212> RNA <213> Homo sapiens <400> 1729 cucugugcug cccccagaa 19 <210> 1730 <211> 19 <212> RNA <213> Homo sapiens <400> 1730 cugugcugcc cccagaaaa 19 <210> 1731 <211> 19 <212> RNA <213> Homo sapiens <400> 1731 ugugcugccc ccagaaaau 19 <210> 1732 <211> 19 <212> RNA <213> Homo sapiens <400> 1732 gugcugcccc cagaaaaua 19 <210> 1733 <211> 19 <212> RNA <213> Homo sapiens <400> 1733 gcugccccca gaaaauauc 19 <210> 1734 <211> 19 <212> RNA <213> Homo sapiens <400> 1734 cccccagaaa auauccugu 19 <210> 1735 <211> 19 <212> RNA <213> Homo sapiens <400> 1735 cccagaaaau auccugucu 19 <210> 1736 <211> 19 <212> RNA <213> Homo sapiens <400> 1736 ccagaaaaua uccugucug 19 <210> 1737 <211> 19 <212> RNA <213> Homo sapiens <400> 1737 cagaaaauau ccugucugc 19 <210> 1738 <211> 19 <212> RNA <213> Homo sapiens <400> 1738 gaaaauaucc ugucugccu 19 <210> 1739 <211> 19 <212> RNA <213> Homo sapiens <400> 1739 aaaauauccu gucugccua 19 <210> 1740 <211> 19 <212> RNA <213> Homo sapiens <400> 1740 aaauauccug ucugccuau 19 <210> 1741 <211> 19 <212> RNA <213> Homo sapiens <400> 1741 ccugucugcc uaucagggu 19 <210> 1742 <211> 19 <212> RNA <213> Homo sapiens <400> 1742 cugucugccu aucagggua 19 <210> 1743 <211> 19 <212> RNA <213> Homo sapiens <400> 1743 gucugccuau caggguacc 19 <210> 1744 <211> 19 <212> RNA <213> Homo sapiens <400> 1744 ugccuaucag gguaccccu 19 <210> 1745 <211> 19 <212> RNA <213> Homo sapiens <400> 1745 gccuaucagg guaccccuc 19 <210> 1746 <211> 19 <212> RNA <213> Homo sapiens <400> 1746 ccuaucaggg uaccccucu 19 <210> 1747 <211> 19 <212> RNA <213> Homo sapiens <400> 1747 cuaucagggu accccucuc 19 <210> 1748 <211> 19 <212> RNA <213> Homo sapiens <400> 1748 caggguaccc cucucccug 19 <210> 1749 <211> 19 <212> RNA <213> Homo sapiens <400> 1749 ggguaccccu cucccugcc 19 <210> 1750 <211> 19 <212> RNA <213> Homo sapiens <400> 1750 gguaccccuc ucccugcca 19 <210> 1751 <211> 19 <212> RNA <213> Homo sapiens <400> 1751 guaccccucu cccugccaa 19 <210> 1752 <211> 19 <212> RNA <213> Homo sapiens <400> 1752 uaccccucuc ccugccaau 19 <210> 1753 <211> 19 <212> RNA <213> Homo sapiens <400> 1753 ccccucuccc ugccaauau 19 <210> 1754 <211> 19 <212> RNA <213> Homo sapiens <400> 1754 cccucucccu gccaauauc 19 <210> 1755 <211> 19 <212> RNA <213> Homo sapiens <400> 1755 cugccaauau ccuggacug 19 <210> 1756 <211> 19 <212> RNA <213> Homo sapiens <400> 1756 ccaauauccu ggacuggca 19 <210> 1757 <211> 19 <212> RNA <213> Homo sapiens <400> 1757 caauauccug gacuggcag 19 <210> 1758 <211> 19 <212> RNA <213> Homo sapiens <400> 1758 uccuggacug gcaggcucu 19 <210> 1759 <211> 19 <212> RNA <213> Homo sapiens <400> 1759 ccuggacugg caggcucug 19 <210> 1760 <211> 19 <212> RNA <213> Homo sapiens <400> 1760 cuggacuggc aggcucuga 19 <210> 1761 <211> 19 <212> RNA <213> Homo sapiens <400> 1761 uggacuggca ggcucugaa 19 <210> 1762 <211> 19 <212> RNA <213> Homo sapiens <400> 1762 ggacuggcag gcucugaac 19 <210> 1763 <211> 19 <212> RNA <213> Homo sapiens <400> 1763 gacuggcagg cucugaacu 19 <210> 1764 <211> 19 <212> RNA <213> Homo sapiens <400> 1764 acuggcaggc ucugaacua 19 <210> 1765 <211> 19 <212> RNA <213> Homo sapiens <400> 1765 cuggcaggcu cugaacuau 19 <210> 1766 <211> 19 <212> RNA <213> Homo sapiens <400> 1766 uggcaggcuc ugaacuaug 19 <210> 1767 <211> 19 <212> RNA <213> Homo sapiens <400> 1767 ggcaggcucu gaacuauga 19 <210> 1768 <211> 19 <212> RNA <213> Homo sapiens <400> 1768 gcaggcucug aacuaugaa 19 <210> 1769 <211> 19 <212> RNA <213> Homo sapiens <400> 1769 caggcucuga acuaugaaa 19 <210> 1770 <211> 19 <212> RNA <213> Homo sapiens <400> 1770 aggcucugaa cuaugaaau 19 <210> 1771 <211> 19 <212> RNA <213> Homo sapiens <400> 1771 ggcucugaac uaugaaauc 19 <210> 1772 <211> 19 <212> RNA <213> Homo sapiens <400> 1772 gcucugaacu augaaauca 19 <210> 1773 <211> 19 <212> RNA <213> Homo sapiens <400> 1773 cucugaacua ugaaaucag 19 <210> 1774 <211> 19 <212> RNA <213> Homo sapiens <400> 1774 ucugaacuau gaaaucaga 19 <210> 1775 <211> 19 <212> RNA <213> Homo sapiens <400> 1775 gaacuaugaa aucagagga 19 <210> 1776 <211> 19 <212> RNA <213> Homo sapiens <400> 1776 aacuaugaaa ucagaggau 19 <210> 1777 <211> 19 <212> RNA <213> Homo sapiens <400> 1777 acuaugaaau cagaggaua 19 <210> 1778 <211> 19 <212> RNA <213> Homo sapiens <400> 1778 cuaugaaauc agaggauau 19 <210> 1779 <211> 19 <212> RNA <213> Homo sapiens <400> 1779 uaugaaauca gaggauaug 19 <210> 1780 <211> 19 <212> RNA <213> Homo sapiens <400> 1780 ugaaaucaga ggauauguc 19 <210> 1781 <211> 19 <212> RNA <213> Homo sapiens <400> 1781 gaaaucagag gauauguca 19 <210> 1782 <211> 19 <212> RNA <213> Homo sapiens <400> 1782 aaaucagagg auaugucau 19 <210> 1783 <211> 19 <212> RNA <213> Homo sapiens <400> 1783 aaucagagga uaugucauc 19 <210> 1784 <211> 19 <212> RNA <213> Homo sapiens <400> 1784 cagaggauau gucaucauc 19 <210> 1785 <211> 19 <212> RNA <213> Homo sapiens <400> 1785 agaggauaug ucaucauca 19 <210> 1786 <211> 19 <212> RNA <213> Homo sapiens <400> 1786 gaggauaugu caucaucaa 19 <210> 1787 <211> 19 <212> RNA <213> Homo sapiens <400> 1787 aggauauguc aucaucaaa 19 <210> 1788 <211> 19 <212> RNA <213> Homo sapiens <400> 1788 ggauauguca ucaucaaac 19 <210> 1789 <211> 19 <212> RNA <213> Homo sapiens <400> 1789 gauaugucau caucaaacc 19 <210> 1790 <211> 19 <212> RNA <213> Homo sapiens <400> 1790 augucaucau caaacccuu 19 <210> 1791 <211> 19 <212> RNA <213> Homo sapiens <400> 1791 caucaucaaa cccuuggug 19 <210> 1792 <211> 19 <212> RNA <213> Homo sapiens <400> 1792 ucaucaaacc cuuggugug 19 <210> 1793 <211> 19 <212> RNA <213> Homo sapiens <400> 1793 acccuuggug ugggucuga 19 <210> 1794 <211> 19 <212> RNA <213> Homo sapiens <400> 1794 cccuuggugu gggucugag 19 <210> 1795 <211> 19 <212> RNA <213> Homo sapiens <400> 1795 ccuuggugug ggucugagg 19 <210> 1796 <211> 19 <212> RNA <213> Homo sapiens <400> 1796 cuuggugugg gucugaggu 19 <210> 1797 <211> 19 <212> RNA <213> Homo sapiens <400> 1797 uggugugggu cugaggucu 19 <210> 1798 <211> 19 <212> RNA <213> Homo sapiens <400> 1798 gguguggguc ugaggucuu 19 <210> 1799 <211> 19 <212> RNA <213> Homo sapiens <400> 1799 gugugggucu gaggucuug 19 <210> 1800 <211> 19 <212> RNA <213> Homo sapiens <400> 1800 ugugggucug aggucuuga 19 <210> 1801 <211> 19 <212> RNA <213> Homo sapiens <400> 1801 gugggucuga ggucuugac 19 <210> 1802 <211> 19 <212> RNA <213> Homo sapiens <400> 1802 gggucugagg ucuugacuc 19 <210> 1803 <211> 19 <212> RNA <213> Homo sapiens <400> 1803 ggucugaggu cuugacuca 19 <210> 1804 <211> 19 <212> RNA <213> Homo sapiens <400> 1804 gucugagguc uugacucaa 19 <210> 1805 <211> 19 <212> RNA <213> Homo sapiens <400> 1805 cugaggucuu gacucaacg 19 <210> 1806 <211> 19 <212> RNA <213> Homo sapiens <400> 1806 ugaggucuug acucaacga 19 <210> 1807 <211> 19 <212> RNA <213> Homo sapiens <400> 1807 gaggucuuga cucaacgag 19 <210> 1808 <211> 19 <212> RNA <213> Homo sapiens <400> 1808 aggucuugac ucaacgaga 19 <210> 1809 <211> 19 <212> RNA <213> Homo sapiens <400> 1809 ggucuugacu caacgagag 19 <210> 1810 <211> 19 <212> RNA <213> Homo sapiens <400> 1810 gucuugacuc aacgagagc 19 <210> 1811 <211> 19 <212> RNA <213> Homo sapiens <400> 1811 ucuugacuca acgagagca 19 <210> 1812 <211> 19 <212> RNA <213> Homo sapiens <400> 1812 cuugacucaa cgagagcac 19 <210> 1813 <211> 19 <212> RNA <213> Homo sapiens <400> 1813 uugacucaac gagagcacu 19 <210> 1814 <211> 19 <212> RNA <213> Homo sapiens <400> 1814 ugacucaacg agagcacuu 19 <210> 1815 <211> 19 <212> RNA <213> Homo sapiens <400> 1815 gacucaacga gagcacuug 19 <210> 1816 <211> 19 <212> RNA <213> Homo sapiens <400> 1816 acucaacgag agcacuuga 19 <210> 1817 <211> 19 <212> RNA <213> Homo sapiens <400> 1817 cucaacgaga gcacuugaa 19 <210> 1818 <211> 19 <212> RNA <213> Homo sapiens <400> 1818 ucaacgagag cacuugaaa 19 <210> 1819 <211> 19 <212> RNA <213> Homo sapiens <400> 1819 caacgagagc acuugaaaa 19 <210> 1820 <211> 19 <212> RNA <213> Homo sapiens <400> 1820 aacgagagca cuugaaaau 19 <210> 1821 <211> 19 <212> RNA <213> Homo sapiens <400> 1821 acgagagcac uugaaaaug 19 <210> 1822 <211> 19 <212> RNA <213> Homo sapiens <400> 1822 cgagagcacu ugaaaauga 19 <210> 1823 <211> 19 <212> RNA <213> Homo sapiens <400> 1823 gagagcacuu gaaaaugaa 19 <210> 1824 <211> 19 <212> RNA <213> Homo sapiens <400> 1824 agagcacuug aaaaugaaa 19 <210> 1825 <211> 19 <212> RNA <213> Homo sapiens <400> 1825 gagcacuuga aaaugaaau 19 <210> 1826 <211> 19 <212> RNA <213> Homo sapiens <400> 1826 agcacuugaa aaugaaaug 19 <210> 1827 <211> 19 <212> RNA <213> Homo sapiens <400> 1827 gcacuugaaa augaaauga 19 <210> 1828 <211> 19 <212> RNA <213> Homo sapiens <400> 1828 cacuugaaaa ugaaaugac 19 <210> 1829 <211> 19 <212> RNA <213> Homo sapiens <400> 1829 acuugaaaau gaaaugacu 19 <210> 1830 <211> 19 <212> RNA <213> Homo sapiens <400> 1830 cuugaaaaug aaaugacug 19 <210> 1831 <211> 19 <212> RNA <213> Homo sapiens <400> 1831 uugaaaauga aaugacugu 19 <210> 1832 <211> 19 <212> RNA <213> Homo sapiens <400> 1832 ugaaaaugaa augacuguc 19 <210> 1833 <211> 19 <212> RNA <213> Homo sapiens <400> 1833 gaaaaugaaa ugacugucu 19 <210> 1834 <211> 19 <212> RNA <213> Homo sapiens <400> 1834 aaaaugaaau gacugucua 19 <210> 1835 <211> 19 <212> RNA <213> Homo sapiens <400> 1835 aaaugaaaug acugucuaa 19 <210> 1836 <211> 19 <212> RNA <213> Homo sapiens <400> 1836 aaugaaauga cugucuaag 19 <210> 1837 <211> 19 <212> RNA <213> Homo sapiens <400> 1837 augaaaugac ugucuaaga 19 <210> 1838 <211> 19 <212> RNA <213> Homo sapiens <400> 1838 ugaaaugacu gucuaagag 19 <210> 1839 <211> 19 <212> RNA <213> Homo sapiens <400> 1839 gaaaugacug ucuaagaga 19 <210> 1840 <211> 19 <212> RNA <213> Homo sapiens <400> 1840 aaaugacugu cuaagagau 19 <210> 1841 <211> 19 <212> RNA <213> Homo sapiens <400> 1841 augacugucu aagagaucu 19 <210> 1842 <211> 19 <212> RNA <213> Homo sapiens <400> 1842 ugacugucua agagaucug 19 <210> 1843 <211> 19 <212> RNA <213> Homo sapiens <400> 1843 gacugucuaa gagaucugg 19 <210> 1844 <211> 19 <212> RNA <213> Homo sapiens <400> 1844 acugucuaag agaucuggu 19 <210> 1845 <211> 19 <212> RNA <213> Homo sapiens <400> 1845 cugucuaaga gaucugguc 19 <210> 1846 <211> 19 <212> RNA <213> Homo sapiens <400> 1846 ugucuaagag aucugguca 19 <210> 1847 <211> 19 <212> RNA <213> Homo sapiens <400> 1847 gucuaagaga ucuggucaa 19 <210> 1848 <211> 19 <212> RNA <213> Homo sapiens <400> 1848 ucuaagagau cuggucaaa 19 <210> 1849 <211> 19 <212> RNA <213> Homo sapiens <400> 1849 cuaagagauc uggucaaag 19 <210> 1850 <211> 19 <212> RNA <213> Homo sapiens <400> 1850 uaagagaucu ggucaaagc 19 <210> 1851 <211> 19 <212> RNA <213> Homo sapiens <400> 1851 aagagaucug gucaaagca 19 <210> 1852 <211> 19 <212> RNA <213> Homo sapiens <400> 1852 agagaucugg ucaaagcaa 19 <210> 1853 <211> 19 <212> RNA <213> Homo sapiens <400> 1853 gagaucuggu caaagcaac 19 <210> 1854 <211> 19 <212> RNA <213> Homo sapiens <400> 1854 agaucugguc aaagcaacu 19 <210> 1855 <211> 19 <212> RNA <213> Homo sapiens <400> 1855 gaucugguca aagcaacug 19 <210> 1856 <211> 19 <212> RNA <213> Homo sapiens <400> 1856 aucuggucaa agcaacugg 19 <210> 1857 <211> 19 <212> RNA <213> Homo sapiens <400> 1857 ucuggucaaa gcaacugga 19 <210> 1858 <211> 19 <212> RNA <213> Homo sapiens <400> 1858 cuggucaaag caacuggau 19 <210> 1859 <211> 19 <212> RNA <213> Homo sapiens <400> 1859 uggucaaagc aacuggaua 19 <210> 1860 <211> 19 <212> RNA <213> Homo sapiens <400> 1860 ggucaaagca acuggauac 19 <210> 1861 <211> 19 <212> RNA <213> Homo sapiens <400> 1861 gucaaagcaa cuggauacu 19 <210> 1862 <211> 19 <212> RNA <213> Homo sapiens <400> 1862 ucaaagcaac uggauacua 19 <210> 1863 <211> 19 <212> RNA <213> Homo sapiens <400> 1863 caaagcaacu ggauacuag 19 <210> 1864 <211> 19 <212> RNA <213> Homo sapiens <400> 1864 aaagcaacug gauacuaga 19 <210> 1865 <211> 19 <212> RNA <213> Homo sapiens <400> 1865 aagcaacugg auacuagau 19 <210> 1866 <211> 19 <212> RNA <213> Homo sapiens <400> 1866 agcaacugga uacuagauc 19 <210> 1867 <211> 19 <212> RNA <213> Homo sapiens <400> 1867 gcaacuggau acuagaucu 19 <210> 1868 <211> 19 <212> RNA <213> Homo sapiens <400> 1868 caacuggaua cuagaucuu 19 <210> 1869 <211> 19 <212> RNA <213> Homo sapiens <400> 1869 aacuggauac uagaucuua 19 <210> 1870 <211> 19 <212> RNA <213> Homo sapiens <400> 1870 acuggauacu agaucuuac 19 <210> 1871 <211> 19 <212> RNA <213> Homo sapiens <400> 1871 cuggauacua gaucuuaca 19 <210> 1872 <211> 19 <212> RNA <213> Homo sapiens <400> 1872 uggauacuag aucuuacau 19 <210> 1873 <211> 19 <212> RNA <213> Homo sapiens <400> 1873 ggauacuaga ucuuacauc 19 <210> 1874 <211> 19 <212> RNA <213> Homo sapiens <400> 1874 gauacuagau cuuacaucu 19 <210> 1875 <211> 19 <212> RNA <213> Homo sapiens <400> 1875 auacuagauc uuacaucug 19 <210> 1876 <211> 19 <212> RNA <213> Homo sapiens <400> 1876 acuagaucuu acaucugca 19 <210> 1877 <211> 19 <212> RNA <213> Homo sapiens <400> 1877 cuagaucuua caucugcag 19 <210> 1878 <211> 19 <212> RNA <213> Homo sapiens <400> 1878 agaucuuaca ucugcagcu 19 <210> 1879 <211> 19 <212> RNA <213> Homo sapiens <400> 1879 gaucuuacau cugcagcuc 19 <210> 1880 <211> 19 <212> RNA <213> Homo sapiens <400> 1880 aucuuacauc ugcagcucu 19 <210> 1881 <211> 19 <212> RNA <213> Homo sapiens <400> 1881 ucuuacaucu gcagcucuu 19 <210> 1882 <211> 19 <212> RNA <213> Homo sapiens <400> 1882 cuuacaucug cagcucuuu 19 <210> 1883 <211> 19 <212> RNA <213> Homo sapiens <400> 1883 uuacaucugc agcucuuuc 19 <210> 1884 <211> 19 <212> RNA <213> Homo sapiens <400> 1884 uacaucugca gcucuuucu 19 <210> 1885 <211> 19 <212> RNA <213> Homo sapiens <400> 1885 acaucugcag cucuuucuu 19 <210> 1886 <211> 19 <212> RNA <213> Homo sapiens <400> 1886 caucugcagc ucuuucuuc 19 <210> 1887 <211> 19 <212> RNA <213> Homo sapiens <400> 1887 aucugcagcu cuuucuucu 19 <210> 1888 <211> 19 <212> RNA <213> Homo sapiens <400> 1888 ucugcagcuc uuucuucuu 19 <210> 1889 <211> 19 <212> RNA <213> Homo sapiens <400> 1889 cugcagcucu uucuucuuu 19 <210> 1890 <211> 19 <212> RNA <213> Homo sapiens <400> 1890 ugcagcucuu ucuucuuug 19 <210> 1891 <211> 19 <212> RNA <213> Homo sapiens <400> 1891 gcagcucuuu cuucuuuga 19 <210> 1892 <211> 19 <212> RNA <213> Homo sapiens <400> 1892 cagcucuuuc uucuuugaa 19 <210> 1893 <211> 19 <212> RNA <213> Homo sapiens <400> 1893 agcucuuucu ucuuugaau 19 <210> 1894 <211> 19 <212> RNA <213> Homo sapiens <400> 1894 gcucuuucuu cuuugaauu 19 <210> 1895 <211> 19 <212> RNA <213> Homo sapiens <400> 1895 cucuuucuuc uuugaauuu 19 <210> 1896 <211> 19 <212> RNA <213> Homo sapiens <400> 1896 ucuuucuucu uugaauuuc 19 <210> 1897 <211> 19 <212> RNA <213> Homo sapiens <400> 1897 cuuucuucuu ugaauuucc 19 <210> 1898 <211> 19 <212> RNA <213> Homo sapiens <400> 1898 uuucuucuuu gaauuuccu 19 <210> 1899 <211> 19 <212> RNA <213> Homo sapiens <400> 1899 uucuucuuug aauuuccua 19 <210> 1900 <211> 19 <212> RNA <213> Homo sapiens <400> 1900 ucuucuuuga auuuccuau 19 <210> 1901 <211> 19 <212> RNA <213> Homo sapiens <400> 1901 uucuuugaau uuccuaucu 19 <210> 1902 <211> 19 <212> RNA <213> Homo sapiens <400> 1902 ucuuugaauu uccuaucug 19 <210> 1903 <211> 19 <212> RNA <213> Homo sapiens <400> 1903 cuuugaauuu ccuaucugu 19 <210> 1904 <211> 19 <212> RNA <213> Homo sapiens <400> 1904 uuugaauuuc cuaucugua 19 <210> 1905 <211> 19 <212> RNA <213> Homo sapiens <400> 1905 uugaauuucc uaucuguau 19 <210> 1906 <211> 19 <212> RNA <213> Homo sapiens <400> 1906 ugaauuuccu aucuguaug 19 <210> 1907 <211> 19 <212> RNA <213> Homo sapiens <400> 1907 gaauuuccua ucuguaugu 19 <210> 1908 <211> 19 <212> RNA <213> Homo sapiens <400> 1908 auuuccuauc uguaugucu 19 <210> 1909 <211> 19 <212> RNA <213> Homo sapiens <400> 1909 uuuccuaucu guaugucug 19 <210> 1910 <211> 19 <212> RNA <213> Homo sapiens <400> 1910 uuccuaucug uaugucugc 19 <210> 1911 <211> 19 <212> RNA <213> Homo sapiens <400> 1911 uccuaucugu augucugcc 19 <210> 1912 <211> 19 <212> RNA <213> Homo sapiens <400> 1912 ccuaucugua ugucugccu 19 <210> 1913 <211> 19 <212> RNA <213> Homo sapiens <400> 1913 cuaucuguau gucugccua 19 <210> 1914 <211> 19 <212> RNA <213> Homo sapiens <400> 1914 uaucuguaug ucugccuaa 19 <210> 1915 <211> 19 <212> RNA <213> Homo sapiens <400> 1915 aucuguaugu cugccuaau 19 <210> 1916 <211> 19 <212> RNA <213> Homo sapiens <400> 1916 ucuguauguc ugccuaauu 19 <210> 1917 <211> 19 <212> RNA <213> Homo sapiens <400> 1917 cuguaugucu gccuaauua 19 <210> 1918 <211> 19 <212> RNA <213> Homo sapiens <400> 1918 uguaugucug ccuaauuaa 19 <210> 1919 <211> 19 <212> RNA <213> Homo sapiens <400> 1919 guaugucugc cuaauuaaa 19 <210> 1920 <211> 19 <212> RNA <213> Homo sapiens <400> 1920 uaugucugcc uaauuaaaa 19 <210> 1921 <211> 19 <212> RNA <213> Homo sapiens <400> 1921 augucugccu aauuaaaaa 19 <210> 1922 <211> 19 <212> RNA <213> Homo sapiens <400> 1922 ugucugccua auuaaaaaa 19 <210> 1923 <211> 19 <212> RNA <213> Homo sapiens <400> 1923 gucugccuaa uuaaaaaaa 19 <210> 1924 <211> 19 <212> RNA <213> Homo sapiens <400> 1924 ucugccuaau uaaaaaaau 19 <210> 1925 <211> 19 <212> RNA <213> Homo sapiens <400> 1925 cugccuaauu aaaaaaaua 19 <210> 1926 <211> 19 <212> RNA <213> Homo sapiens <400> 1926 ugccuaauua aaaaaauau 19 <210> 1927 <211> 19 <212> RNA <213> Homo sapiens <400> 1927 gccuaauuaa aaaaauaua 19 <210> 1928 <211> 19 <212> RNA <213> Homo sapiens <400> 1928 ccuaauuaaa aaaauauau 19 <210> 1929 <211> 19 <212> RNA <213> Homo sapiens <400> 1929 cuaauuaaaa aaauauaua 19 <210> 1930 <211> 19 <212> RNA <213> Homo sapiens <400> 1930 uaaaaaaaua uauauugua 19 <210> 1931 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <220> <221> modified_base <222> (1)..(1) <223> 2'-fluorouracil <220> <221> modified_base <222> (2)..(2) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (3)..(3) <223> 2'-fluorocytosine <220> <221> modified_base <222> (4)..(4) <223> cm <220> <221> modified_base <222> (5)..(5) <223> 2'-fluorouracil <220> <221> modified_base <222> (6)..(6) <223> um <220> <221> modified_base <222> (7)..(7) <223> 2'-fluoroguanine <220> <221> modified_base <222> (8)..(8) <223> um <220> <221> modified_base <222> (9)..(9) <223> 2'-fluoroguanine <220> <221> modified_base <222> (10)..(10) <223> um <220> <221> modified_base <222> (11)..(12) <223> 2'-fluorouracil <220> <221> modified_base <222> (13)..(13) <223> um <220> <221> modified_base <222> (14)..(14) <223> 2'-fluorocytosine <220> <221> modified_base <222> (15)..(15) <223> gm <220> <221> modified_base <222> (16)..(16) <223> 2'-fluoroadenine <220> <221> modified_base <222> (17)..(17) <223> gm <220> <221> modified_base <222> (18)..(18) <223> 2'-fluorocytosine <220> <221> modified_base <222> (19)..(19) <223> cm <220> <221> modified_base <222> (20)..(20) <223> 2'-fluorouracil <220> <221> modified_base <222> (21)..(21) <223> 2'-O-methyladenosine <400> 1931 uaccuugugu uuucgagccu a 21 <210> 1932 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <220> <221> modified_base <222> (1)..(1) <223> 2'-fluorouracil <220> <221> modified_base <222> (2)..(2) <223> gm <220> <221> modified_base <222> (3)..(3) <223> 2'-fluorocytosine <220> <221> modified_base <222> (4)..(4) <223> cm <220> <221> modified_base <222> (5)..(5) <223> 2'-fluorouracil <220> <221> modified_base <222> (6)..(6) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (7)..(7) <223> 2'-fluorocytosine <220> <221> modified_base <222> (8)..(8) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (9)..(9) <223> 2'-fluoroguanine <220> <221> modified_base <222> (10)..(10) <223> cm <220> <221> modified_base <222> (11)..(11) <223> 2'-fluorocytosine <220> <221> modified_base <222> (12)..(12) <223> 2'-fluorouracil <220> <221> modified_base <222> (13)..(13) <223> cm <220> <221> modified_base <222> (14)..(14) <223> 2'-fluorouracil <220> <221> modified_base <222> (15)..(15) <223> um <220> <221> modified_base <222> (16)..(16) <223> 2'-fluorocytosine <220> <221> modified_base <222> (17)..(17) <223> um <220> <221> modified_base <222> (18)..(18) <223> 2'-fluorocytosine <220> <221> modified_base <222> (19)..(19) <223> cm <220> <221> modified_base <222> (20)..(20) <223> 2'-fluorouracil <220> <221> modified_base <222> (21)..(21) <223> 2'-O-methyladenosine <400> 1932 ugccuacagc cucuucuccu a 21 <210> 1933 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <220> <221> modified_base <222> (1)..(1) <223> 2'-fluoroadenine <220> <221> modified_base <222> (2)..(2) <223> cm <220> <221> modified_base <222> (3)..(3) <223> 2'-fluoroadenine <220> <221> modified_base <222> (4)..(4) <223> gm <220> <221> modified_base <222> (5)..(5) <223> 2'-fluorocytosine <220> <221> modified_base <222> (6)..(6) <223> cm <220> <221> modified_base <222> (7)..(7) <223> 2'-fluorouracil <220> <221> modified_base <222> (8)..(8) <223> cm <220> <221> modified_base <222> (9)..(9) <223> 2'-fluorouracil <220> <221> modified_base <222> (10)..(10) <223> um <220> <221> modified_base <222> (11)..(11) <223> 2'-fluorocytosine <220> <221> modified_base <222> (12)..(12) <223> 2'-fluorouracil <220> <221> modified_base <222> (13)..(13) <223> cm <220> <221> modified_base <222> (14)..(14) <223> 2'-fluorocytosine <220> <221> modified_base <222> (15)..(15) <223> um <220> <221> modified_base <222> (16)..(16) <223> 2'-fluoroadenine <220> <221> modified_base <222> (17)..(17) <223> cm <220> <221> modified_base <222> (18)..(18) <223> 2'-fluoroadenine <220> <221> modified_base <222> (19)..(19) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (20)..(20) <223> 2'-fluorouracil <220> <221> modified_base <222> (21)..(21) <223> 2'-O-methyladenosine <400> 1933 acagccucuu cuccuacaau a 21 <210> 1934 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <220> <221> modified_base <222> (1)..(1) <223> 2'-fluoroguanine <220> <221> modified_base <222> (2)..(2) <223> um <220> <221> modified_base <222> (3)..(3) <223> 2'-fluorocytosine <220> <221> modified_base <222> (4)..(4) <223> cm <220> <221> modified_base <222> (5)..(5) <223> 2'-fluorouracil <220> <221> modified_base <222> (6)..(6) <223> cm <220> <221> modified_base <222> (7)..(7) <223> 2'-fluoroadenine <220> <221> modified_base <222> (8)..(8) <223> um <220> <221> modified_base <222> (9)..(9) <223> 2'-fluorocytosine <220> <221> modified_base <222> (10)..(10) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (11)..(12) <223> 2'-fluoroguanine <220> <221> modified_base <222> (13)..(13) <223> um <220> <221> modified_base <222> (14)..(14) <223> 2'-fluoroadenine <220> <221> modified_base <222> (15)..(15) <223> um <220> <221> modified_base <222> (16)..(16) <223> 2'-fluorouracil <220> <221> modified_base <222> (17)..(17) <223> gm <220> <221> modified_base <222> (18)..(18) <223> 2'-fluorocytosine <220> <221> modified_base <222> (19)..(19) <223> um <220> <221> modified_base <222> (20)..(20) <223> 2'-fluoroguanine <220> <221> modified_base <222> (21)..(21) <223> 2'-O-methyladenosine <400> 1934 guccucauca gguauugcug a 21 <210> 1935 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <220> <221> modified_base <222> (1)..(1) <223> 2'-fluoroadenine <220> <221> modified_base <222> (2)..(2) <223> gm <220> <221> modified_base <222> (3)..(3) <223> 2'-fluoroguanine <220> <221> modified_base <222> (4)..(4) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (5)..(5) <223> 2'-fluoroguanine <220> <221> modified_base <222> (6)..(6) <223> cm <220> <221> modified_base <222> (7)..(7) <223> 2'-fluorocytosine <220> <221> modified_base <222> (8)..(8) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (9)..(9) <223> 2'-fluoroguanine <220> <221> modified_base <222> (10)..(10) <223> um <220> <221> modified_base <222> (11)..(12) <223> 2'-fluorocytosine <220> <221> modified_base <222> (13)..(13) <223> um <220> <221> modified_base <222> (14)..(14) <223> 2'-fluorouracil <220> <221> modified_base <222> (15)..(15) <223> um <220> <221> modified_base <222> (16)..(16) <223> 2'-fluoroguanine <220> <221> modified_base <222> (17)..(17) <223> um <220> <221> modified_base <222> (18)..(18) <223> 2'-fluoroguanine <220> <221> modified_base <222> (19)..(19) <223> gm <220> <221> modified_base <222> (20)..(20) <223> 2'-fluoroguanine <220> <221> modified_base <222> (21)..(21) <223> 2'-O-methyladenosine <400> 1935 aggagccagu ccuuuguggg a 21 <210> 1936 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <220> <221> modified_base <222> (1)..(1) <223> 2'-fluoroguanine <220> <221> modified_base <222> (2)..(2) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (3)..(3) <223> 2'-fluoroguanine <220> <221> modified_base <222> (4)..(4) <223> cm <220> <221> modified_base <222> (5)..(5) <223> 2'-fluorocytosine <220> <221> modified_base <222> (6)..(6) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (7)..(7) <223> 2'-fluoroguanine <220> <221> modified_base <222> (8)..(8) <223> um <220> <221> modified_base <222> (9)..(9) <223> 2'-fluorocytosine <220> <221> modified_base <222> (10)..(10) <223> cm <220> <221> modified_base <222> (11)..(12) <223> 2'-fluorouracil <220> <221> modified_base <222> (13)..(13) <223> um <220> <221> modified_base <222> (14)..(14) <223> 2'-fluoroguanine <220> <221> modified_base <222> (15)..(15) <223> um <220> <221> modified_base <222> (16)..(16) <223> 2'-fluoroguanine <220> <221> modified_base <222> (17)..(17) <223> gm <220> <221> modified_base <222> (18)..(18) <223> 2'-fluoroguanine <220> <221> modified_base <222> (19)..(19) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (20)..(20) <223> 2'-fluoroguanine <220> <221> modified_base <222> (21)..(21) <223> 2'-O-methyladenosine <400> 1936 gagccagucc uuugugggag a 21 <210> 1937 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <220> <221> modified_base <222> (1)..(1) <223> 2'-fluorocytosine <220> <221> modified_base <222> (2)..(2) <223> cm <220> <221> modified_base <222> (3)..(3) <223> 2'-fluoroadenine <220> <221> modified_base <222> (4)..(4) <223> gm <220> <221> modified_base <222> (5)..(5) <223> 2'-fluorouracil <220> <221> modified_base <222> (6)..(6) <223> cm <220> <221> modified_base <222> (7)..(7) <223> 2'-fluorocytosine <220> <221> modified_base <222> (8)..(8) <223> um <220> <221> modified_base <222> (9)..(9) <223> 2'-fluorouracil <220> <221> modified_base <222> (10)..(10) <223> um <220> <221> modified_base <222> (11)..(11) <223> 2'-fluoroguanine <220> <221> modified_base <222> (12)..(12) <223> 2'-fluorouracil <220> <221> modified_base <222> (13)..(13) <223> gm <220> <221> modified_base <222> (14)..(14) <223> 2'-fluoroguanine <220> <221> modified_base <222> (15)..(15) <223> gm <220> <221> modified_base <222> (16)..(16) <223> 2'-fluoroadenine <220> <221> modified_base <222> (17)..(17) <223> gm <220> <221> modified_base <222> (18)..(18) <223> 2'-fluoroadenine <220> <221> modified_base <222> (19)..(19) <223> gm <220> <221> modified_base <222> (20)..(20) <223> 2'-fluoroadenine <220> <221> modified_base <222> (21)..(21) <223> um <400> 1937 ccaguccuuu gugggagaga u 21 <210> 1938 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <220> <221> modified_base <222> (1)..(1) <223> 2'-fluorocytosine <220> <221> modified_base <222> (2)..(2) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (3)..(3) <223> 2'-fluoroguanine <220> <221> modified_base <222> (4)..(4) <223> um <220> <221> modified_base <222> (5)..(5) <223> 2'-fluorocytosine <220> <221> modified_base <222> (6)..(6) <223> cm <220> <221> modified_base <222> (7)..(7) <223> 2'-fluorouracil <220> <221> modified_base <222> (8)..(8) <223> um <220> <221> modified_base <222> (9)..(9) <223> 2'-fluorouracil <220> <221> modified_base <222> (10)..(10) <223> gm <220> <221> modified_base <222> (11)..(11) <223> 2'-fluorouracil <220> <221> modified_base <222> (12)..(12) <223> 2'-fluoroguanine <220> <221> modified_base <222> (13)..(13) <223> gm <220> <221> modified_base <222> (14)..(14) <223> 2'-fluoroguanine <220> <221> modified_base <222> (15)..(15) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (16)..(16) <223> 2'-fluoroguanine <220> <221> modified_base <222> (17)..(17) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (18)..(18) <223> 2'-fluoroguanine <220> <221> modified_base <222> (19)..(19) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (20)..(20) <223> 2'-fluorouracil <220> <221> modified_base <222> (21)..(21) <223> um <400> 1938 caguccuuug ugggagagau u 21 <210> 1939 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <220> <221> modified_base <222> (1)..(1) <223> 2'-fluorouracil <220> <221> modified_base <222> (2)..(2) <223> gm <220> <221> modified_base <222> (3)..(3) <223> 2'-fluoroguanine <220> <221> modified_base <222> (4)..(4) <223> gm <220> <221> modified_base <222> (5)..(5) <223> 2'-fluoroadenine <220> <221> modified_base <222> (6)..(6) <223> gm <220> <221> modified_base <222> (7)..(7) <223> 2'-fluoroadenine <220> <221> modified_base <222> (8)..(8) <223> gm <220> <221> modified_base <222> (9)..(9) <223> 2'-fluoroadenine <220> <221> modified_base <222> (10)..(10) <223> um <220> <221> modified_base <222> (11)..(11) <223> 2'-fluorouracil <220> <221> modified_base <222> (12)..(12) <223> 2'-fluoroguanine <220> <221> modified_base <222> (13)..(13) <223> gm <220> <221> modified_base <222> (14)..(14) <223> 2'-fluoroguanine <220> <221> modified_base <222> (15)..(15) <223> gm <220> <221> modified_base <222> (16)..(16) <223> 2'-fluoroadenine <220> <221> modified_base <222> (17)..(17) <223> um <220> <221> modified_base <222> (18)..(18) <223> 2'-fluorouracil <220> <221> modified_base <222> (19)..(19) <223> um <220> <221> modified_base <222> (20)..(20) <223> 2'-fluoroguanine <220> <221> modified_base <222> (21)..(21) <223> um <400> 1939 ugggagagau uggggauuug u 21 <210> 1940 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <220> <221> modified_base <222> (1)..(1) <223> 2'-fluoroguanine <220> <221> modified_base <222> (2)..(2) <223> gm <220> <221> modified_base <222> (3)..(3) <223> 2'-fluoroguanine <220> <221> modified_base <222> (4)..(4) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (5)..(5) <223> 2'-fluoroguanine <220> <221> modified_base <222> (6)..(6) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (7)..(7) <223> 2'-fluoroguanine <220> <221> modified_base <222> (8)..(8) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (9)..(9) <223> 2'-fluorouracil <220> <221> modified_base <222> (10)..(10) <223> um <220> <221> modified_base <222> (11)..(12) <223> 2'-fluoroguanine <220> <221> modified_base <222> (13)..(13) <223> gm <220> <221> modified_base <222> (14)..(14) <223> 2'-fluoroguanine <220> <221> modified_base <222> (15)..(15) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (16)..(16) <223> 2'-fluorouracil <220> <221> modified_base <222> (17)..(17) <223> um <220> <221> modified_base <222> (18)..(18) <223> 2'-fluorouracil <220> <221> modified_base <222> (19)..(19) <223> gm <220> <221> modified_base <222> (20)..(20) <223> 2'-fluorouracil <220> <221> modified_base <222> (21)..(21) <223> 2'-O-methyladenosine <400> 1940 gggagagauu ggggauuugu a 21 <210> 1941 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <220> <221> modified_base <222> (1)..(1) <223> 2'-fluoroguanine <220> <221> modified_base <222> (2)..(2) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (3)..(3) <223> 2'-fluoroguanine <220> <221> modified_base <222> (4)..(4) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (5)..(5) <223> 2'-fluoroguanine <220> <221> modified_base <222> (6)..(6) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (7)..(7) <223> 2'-fluorouracil <220> <221> modified_base <222> (8)..(8) <223> um <220> <221> modified_base <222> (9)..(9) <223> 2'-fluoroguanine <220> <221> modified_base <222> (10)..(10) <223> gm <220> <221> modified_base <222> (11)..(12) <223> 2'-fluoroguanine <220> <221> modified_base <222> (13)..(13) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (14)..(14) <223> 2'-fluorouracil <220> <221> modified_base <222> (15)..(15) <223> um <220> <221> modified_base <222> (16)..(16) <223> 2'-fluorouracil <220> <221> modified_base <222> (17)..(17) <223> gm <220> <221> modified_base <222> (18)..(18) <223> 2'-fluorouracil <220> <221> modified_base <222> (19)..(19) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (20)..(20) <223> 2'-fluorocytosine <220> <221> modified_base <222> (21)..(21) <223> 2'-O-methyladenosine <400> 1941 gagagauugg ggauuuguac a 21 <210> 1942 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <220> <221> modified_base <222> (1)..(1) <223> 2'-fluorouracil <220> <221> modified_base <222> (2)..(2) <223> cm <220> <221> modified_base <222> (3)..(3) <223> 2'-fluorocytosine <220> <221> modified_base <222> (4)..(4) <223> um <220> <221> modified_base <222> (5)..(5) <223> 2'-fluoroguanine <220> <221> modified_base <222> (6)..(6) <223> um <220> <221> modified_base <222> (7)..(7) <223> 2'-fluorocytosine <220> <221> modified_base <222> (8)..(8) <223> um <220> <221> modified_base <222> (9)..(9) <223> 2'-fluoroguanine <220> <221> modified_base <222> (10)..(10) <223> cm <220> <221> modified_base <222> (11)..(11) <223> 2'-fluorocytosine <220> <221> modified_base <222> (12)..(12) <223> 2'-fluorouracil <220> <221> modified_base <222> (13)..(13) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (14)..(14) <223> 2'-fluorouracil <220> <221> modified_base <222> (15)..(15) <223> cm <220> <221> modified_base <222> (16)..(16) <223> 2'-fluoroadenine <220> <221> modified_base <222> (17)..(17) <223> gm <220> <221> modified_base <222> (18)..(18) <223> 2'-fluoroguanine <220> <221> modified_base <222> (19)..(19) <223> gm <220> <221> modified_base <222> (20)..(20) <223> 2'-fluorouracil <220> <221> modified_base <222> (21)..(21) <223> 2'-O-methyladenosine <400> 1942 uccugucugc cuaucagggu a 21 <210> 1943 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <220> <221> modified_base <222> (1)..(1) <223> 2'-fluorocytosine <220> <221> modified_base <222> (2)..(2) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (3)..(3) <223> 2'-fluoroguanine <220> <221> modified_base <222> (4)..(4) <223> gm <220> <221> modified_base <222> (5)..(5) <223> 2'-fluorocytosine <220> <221> modified_base <222> (6)..(6) <223> um <220> <221> modified_base <222> (7)..(7) <223> 2'-fluorocytosine <220> <221> modified_base <222> (8)..(8) <223> um <220> <221> modified_base <222> (9)..(9) <223> 2'-fluoroguanine <220> <221> modified_base <222> (10)..(10) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (11)..(11) <223> 2'-fluoroadenine <220> <221> modified_base <222> (12)..(12) <223> 2'-fluorocytosine <220> <221> modified_base <222> (13)..(13) <223> um <220> <221> modified_base <222> (14)..(14) <223> 2'-fluoroadenine <220> <221> modified_base <222> (15)..(15) <223> um <220> <221> modified_base <222> (16)..(16) <223> 2'-fluoroguanine <220> <221> modified_base <222> (17)..(17) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (18)..(18) <223> 2'-fluoroadenine <220> <221> modified_base <222> (19)..(19) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (20)..(20) <223> 2'-fluorouracil <220> <221> modified_base <222> (21)..(21) <223> cm <400> 1943 caggcucuga acuaugaaau c 21 <210> 1944 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <220> <221> modified_base <222> (1)..(1) <223> 2'-fluoroguanine <220> <221> modified_base <222> (2)..(2) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (3)..(3) <223> 2'-fluoroguanine <220> <221> modified_base <222> (4)..(4) <223> gm <220> <221> modified_base <222> (5)..(5) <223> 2'-fluoroadenine <220> <221> modified_base <222> (6)..(6) <223> um <220> <221> modified_base <222> (7)..(7) <223> 2'-fluoroadenine <220> <221> modified_base <222> (8)..(8) <223> um <220> <221> modified_base <222> (9)..(9) <223> 2'-fluoroguanine <220> <221> modified_base <222> (10)..(10) <223> um <220> <221> modified_base <222> (11)..(11) <223> 2'-fluorocytosine <220> <221> modified_base <222> (12)..(12) <223> 2'-fluoroadenine <220> <221> modified_base <222> (13)..(13) <223> um <220> <221> modified_base <222> (14)..(14) <223> 2'-fluorocytosine <220> <221> modified_base <222> (15)..(15) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (16)..(16) <223> 2'-fluorouracil <220> <221> modified_base <222> (17)..(17) <223> cm <220> <221> modified_base <222> (18)..(18) <223> 2'-fluoroadenine <220> <221> modified_base <222> (19)..(19) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (20)..(20) <223> 2'-fluoroadenine <220> <221> modified_base <222> (21)..(21) <223> cm <400> 1944 gaggauaugu caucaucaaa c 21 <210> 1945 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <220> <221> modified_base <222> (1)..(1) <223> 2'-fluorouracil <220> <221> modified_base <222> (2)..(2) <223> gm <220> <221> modified_base <222> (3)..(3) <223> 2'-fluoroguanine <220> <221> modified_base <222> (4)..(4) <223> gm <220> <221> modified_base <222> (5)..(5) <223> 2'-fluorouracil <220> <221> modified_base <222> (6)..(6) <223> cm <220> <221> modified_base <222> (7)..(7) <223> 2'-fluorouracil <220> <221> modified_base <222> (8)..(8) <223> gm <220> <221> modified_base <222> (9)..(9) <223> 2'-fluoroadenine <220> <221> modified_base <222> (10)..(10) <223> gm <220> <221> modified_base <222> (11)..(11) <223> 2'-fluoroguanine <220> <221> modified_base <222> (12)..(12) <223> 2'-fluorouracil <220> <221> modified_base <222> (13)..(13) <223> cm <220> <221> modified_base <222> (14)..(14) <223> 2'-fluorouracil <220> <221> modified_base <222> (15)..(15) <223> um <220> <221> modified_base <222> (16)..(16) <223> 2'-fluoroguanine <220> <221> modified_base <222> (17)..(17) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (18)..(18) <223> 2'-fluorocytosine <220> <221> modified_base <222> (19)..(19) <223> um <220> <221> modified_base <222> (20)..(20) <223> 2'-fluorocytosine <220> <221> modified_base <222> (21)..(21) <223> 2'-O-methyladenosine <400> 1945 ugggucugag gucuugacuc a 21 <210> 1946 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <220> <221> modified_base <222> (1)..(1) <223> 2'-fluoroadenine <220> <221> modified_base <222> (2)..(2) <223> cm <220> <221> modified_base <222> (3)..(3) <223> 2'-fluorouracil <220> <221> modified_base <222> (4)..(4) <223> cm <220> <221> modified_base <222> (5)..(5) <223> 2'-fluoroadenine <220> <221> modified_base <222> (6)..(6) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (7)..(7) <223> 2'-fluorocytosine <220> <221> modified_base <222> (8)..(8) <223> gm <220> <221> modified_base <222> (9)..(9) <223> 2'-fluoroadenine <220> <221> modified_base <222> (10)..(10) <223> gm <220> <221> modified_base <222> (11)..(11) <223> 2'-fluoroadenine <220> <221> modified_base <222> (12)..(12) <223> 2'-fluoroguanine <220> <221> modified_base <222> (13)..(13) <223> cm <220> <221> modified_base <222> (14)..(14) <223> 2'-fluoroadenine <220> <221> modified_base <222> (15)..(15) <223> cm <220> <221> modified_base <222> (16)..(16) <223> 2'-fluorouracil <220> <221> modified_base <222> (17)..(17) <223> um <220> <221> modified_base <222> (18)..(18) <223> 2'-fluoroguanine <220> <221> modified_base <222> (19)..(19) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (20)..(20) <223> 2'-fluoroadenine <220> <221> modified_base <222> (21)..(21) <223> 2'-O-methyladenosine <400> 1946 acucaacgag agcacuugaa a 21 <210> 1947 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <220> <221> modified_base <222> (1)..(1) <223> 2'-fluorocytosine <220> <221> modified_base <222> (2)..(2) <223> um <220> <221> modified_base <222> (3)..(3) <223> 2'-fluorocytosine <220> <221> modified_base <222> (4)..(4) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (5)..(5) <223> 2'-fluoroadenine <220> <221> modified_base <222> (6)..(6) <223> cm <220> <221> modified_base <222> (7)..(7) <223> 2'-fluoroguanine <220> <221> modified_base <222> (8)..(8) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (9)..(9) <223> 2'-fluoroguanine <220> <221> modified_base <222> (10)..(10) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (11)..(11) <223> 2'-fluoroguanine <220> <221> modified_base <222> (12)..(12) <223> 2'-fluorocytosine <220> <221> modified_base <222> (13)..(13) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (14)..(14) <223> 2'-fluorocytosine <220> <221> modified_base <222> (15)..(15) <223> um <220> <221> modified_base <222> (16)..(16) <223> 2'-fluorouracil <220> <221> modified_base <222> (17)..(17) <223> gm <220> <221> modified_base <222> (18)..(18) <223> 2'-fluoroadenine <220> <221> modified_base <222> (19)..(19) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (20)..(20) <223> 2'-fluoroadenine <220> <221> modified_base <222> (21)..(21) <223> 2'-O-methyladenosine <400> 1947 cucaacgaga gcacuugaaa a 21 <210> 1948 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <220> <221> modified_base <222> (1)..(1) <223> 2'-fluorouracil <220> <221> modified_base <222> (2)..(2) <223> cm <220> <221> modified_base <222> (3)..(3) <223> 2'-fluoroadenine <220> <221> modified_base <222> (4)..(4) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (5)..(5) <223> 2'-fluorocytosine <220> <221> modified_base <222> (6)..(6) <223> gm <220> <221> modified_base <222> (7)..(7) <223> 2'-fluoroadenine <220> <221> modified_base <222> (8)..(8) <223> gm <220> <221> modified_base <222> (9)..(9) <223> 2'-fluoroadenine <220> <221> modified_base <222> (10)..(10) <223> gm <220> <221> modified_base <222> (11)..(11) <223> 2'-fluorocytosine <220> <221> modified_base <222> (12)..(12) <223> 2'-fluoroadenine <220> <221> modified_base <222> (13)..(13) <223> cm <220> <221> modified_base <222> (14)..(14) <223> 2'-fluorouracil <220> <221> modified_base <222> (15)..(15) <223> um <220> <221> modified_base <222> (16)..(16) <223> 2'-fluoroguanine <220> <221> modified_base <222> (17)..(17) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (18)..(18) <223> 2'-fluoroadenine <220> <221> modified_base <222> (19)..(19) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (20)..(20) <223> 2'-fluoroadenine <220> <221> modified_base <222> (21)..(21) <223> um <400> 1948 ucaacgagag cacuugaaaa u 21 <210> 1949 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <220> <221> modified_base <222> (1)..(1) <223> 2'-fluoroadenine <220> <221> modified_base <222> (2)..(2) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (3)..(3) <223> 2'-fluorocytosine <220> <221> modified_base <222> (4)..(4) <223> gm <220> <221> modified_base <222> (5)..(5) <223> 2'-fluoroadenine <220> <221> modified_base <222> (6)..(6) <223> gm <220> <221> modified_base <222> (7)..(7) <223> 2'-fluoroadenine <220> <221> modified_base <222> (8)..(8) <223> gm <220> <221> modified_base <222> (9)..(9) <223> 2'-fluorocytosine <220> <221> modified_base <222> (10)..(10) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (11)..(11) <223> 2'-fluorocytosine <220> <221> modified_base <222> (12)..(12) <223> 2'-fluorouracil <220> <221> modified_base <222> (13)..(13) <223> um <220> <221> modified_base <222> (14)..(14) <223> 2'-fluoroguanine <220> <221> modified_base <222> (15)..(15) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (16)..(16) <223> 2'-fluoroadenine <220> <221> modified_base <222> (17)..(17) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (18)..(18) <223> 2'-fluoroadenine <220> <221> modified_base <222> (19)..(19) <223> um <220> <221> modified_base <222> (20)..(20) <223> 2'-fluoroguanine <220> <221> modified_base <222> (21)..(21) <223> 2'-O-methyladenosine <400> 1949 aacgagagca cuugaaaaug a 21 <210> 1950 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <220> <221> modified_base <222> (1)..(1) <223> 2'-fluoroadenine <220> <221> modified_base <222> (2)..(2) <223> cm <220> <221> modified_base <222> (3)..(3) <223> 2'-fluoroguanine <220> <221> modified_base <222> (4)..(4) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (5)..(5) <223> 2'-fluoroguanine <220> <221> modified_base <222> (6)..(6) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (7)..(7) <223> 2'-fluoroguanine <220> <221> modified_base <222> (8)..(8) <223> cm <220> <221> modified_base <222> (9)..(9) <223> 2'-fluoroadenine <220> <221> modified_base <222> (10)..(10) <223> cm <220> <221> modified_base <222> (11)..(12) <223> 2'-fluorouracil <220> <221> modified_base <222> (13)..(13) <223> gm <220> <221> modified_base <222> (14)..(14) <223> 2'-fluoroadenine <220> <221> modified_base <222> (15)..(15) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (16)..(16) <223> 2'-fluoroadenine <220> <221> modified_base <222> (17)..(17) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (18)..(18) <223> 2'-fluorouracil <220> <221> modified_base <222> (19)..(19) <223> gm <220> <221> modified_base <222> (20)..(20) <223> 2'-fluoroadenine <220> <221> modified_base <222> (21)..(21) <223> 2'-O-methyladenosine <400> 1950 acgagagcac uugaaaauga a 21 <210> 1951 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <220> <221> modified_base <222> (1)..(1) <223> 2'-fluorocytosine <220> <221> modified_base <222> (2)..(2) <223> gm <220> <221> modified_base <222> (3)..(3) <223> 2'-fluoroadenine <220> <221> modified_base <222> (4)..(4) <223> gm <220> <221> modified_base <222> (5)..(5) <223> 2'-fluoroadenine <220> <221> modified_base <222> (6)..(6) <223> gm <220> <221> modified_base <222> (7)..(7) <223> 2'-fluorocytosine <220> <221> modified_base <222> (8)..(8) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (9)..(9) <223> 2'-fluorocytosine <220> <221> modified_base <222> (10)..(10) <223> um <220> <221> modified_base <222> (11)..(11) <223> 2'-fluorouracil <220> <221> modified_base <222> (12)..(12) <223> 2'-fluoroguanine <220> <221> modified_base <222> (13)..(13) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (14)..(14) <223> 2'-fluoroadenine <220> <221> modified_base <222> (15)..(15) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (16)..(16) <223> 2'-fluoroadenine <220> <221> modified_base <222> (17)..(17) <223> um <220> <221> modified_base <222> (18)..(18) <223> 2'-fluoroguanine <220> <221> modified_base <222> (19)..(19) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (20)..(20) <223> 2'-fluoroadenine <220> <221> modified_base <222> (21)..(21) <223> 2'-O-methyladenosine <400> 1951 cgagagcacu ugaaaaugaa a 21 <210> 1952 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <220> <221> modified_base <222> (1)..(1) <223> 2'-fluoroguanine <220> <221> modified_base <222> (2)..(2) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (3)..(3) <223> 2'-fluoroguanine <220> <221> modified_base <222> (4)..(4) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (5)..(5) <223> 2'-fluoroguanine <220> <221> modified_base <222> (6)..(6) <223> cm <220> <221> modified_base <222> (7)..(7) <223> 2'-fluoroadenine <220> <221> modified_base <222> (8)..(8) <223> cm <220> <221> modified_base <222> (9)..(9) <223> 2'-fluorouracil <220> <221> modified_base <222> (10)..(10) <223> um <220> <221> modified_base <222> (11)..(11) <223> 2'-fluoroguanine <220> <221> modified_base <222> (12)..(12) <223> 2'-fluoroadenine <220> <221> modified_base <222> (13)..(13) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (14)..(14) <223> 2'-fluoroadenine <220> <221> modified_base <222> (15)..(15) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (16)..(16) <223> 2'-fluorouracil <220> <221> modified_base <222> (17)..(17) <223> gm <220> <221> modified_base <222> (18)..(18) <223> 2'-fluoroadenine <220> <221> modified_base <222> (19)..(19) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (20)..(20) <223> 2'-fluoroadenine <220> <221> modified_base <222> (21)..(21) <223> um <400> 1952 gagagcacuu gaaaaugaaa u 21 <210> 1953 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <220> <221> modified_base <222> (1)..(1) <223> 2'-fluoroadenine <220> <221> modified_base <222> (2)..(2) <223> gm <220> <221> modified_base <222> (3)..(3) <223> 2'-fluoroadenine <220> <221> modified_base <222> (4)..(4) <223> gm <220> <221> modified_base <222> (5)..(5) <223> 2'-fluorocytosine <220> <221> modified_base <222> (6)..(6) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (7)..(7) <223> 2'-fluorocytosine <220> <221> modified_base <222> (8)..(8) <223> um <220> <221> modified_base <222> (9)..(9) <223> 2'-fluorouracil <220> <221> modified_base <222> (10)..(10) <223> gm <220> <221> modified_base <222> (11)..(12) <223> 2'-fluoroadenine <220> <221> modified_base <222> (13)..(13) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (14)..(14) <223> 2'-fluoroadenine <220> <221> modified_base <222> (15)..(15) <223> um <220> <221> modified_base <222> (16)..(16) <223> 2'-fluoroguanine <220> <221> modified_base <222> (17)..(17) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (18)..(18) <223> 2'-fluoroadenine <220> <221> modified_base <222> (19)..(19) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (20)..(20) <223> 2'-fluorouracil <220> <221> modified_base <222> (21)..(21) <223> gm <400> 1953 agagcacuug aaaaugaaau g 21 <210> 1954 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <220> <221> modified_base <222> (1)..(1) <223> 2'-fluorocytosine <220> <221> modified_base <222> (2)..(2) <223> um <220> <221> modified_base <222> (3)..(3) <223> 2'-fluoroadenine <220> <221> modified_base <222> (4)..(4) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (5)..(5) <223> 2'-fluoroguanine <220> <221> modified_base <222> (6)..(6) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (7)..(7) <223> 2'-fluoroguanine <220> <221> modified_base <222> (8)..(8) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (9)..(9) <223> 2'-fluorouracil <220> <221> modified_base <222> (10)..(10) <223> cm <220> <221> modified_base <222> (11)..(11) <223> 2'-fluorouracil <220> <221> modified_base <222> (12)..(12) <223> 2'-fluoroguanine <220> <221> modified_base <222> (13)..(13) <223> gm <220> <221> modified_base <222> (14)..(14) <223> 2'-fluorouracil <220> <221> modified_base <222> (15)..(15) <223> cm <220> <221> modified_base <222> (16)..(16) <223> 2'-fluoroadenine <220> <221> modified_base <222> (17)..(17) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (18)..(18) <223> 2'-fluoroadenine <220> <221> modified_base <222> (19)..(19) <223> gm <220> <221> modified_base <222> (20)..(20) <223> 2'-fluorocytosine <220> <221> modified_base <222> (21)..(21) <223> 2'-O-methyladenosine <400> 1954 cuaagagauc uggucaaagc a 21 <210> 1955 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <220> <221> modified_base <222> (1)..(1) <223> 2'-fluorocytosine <220> <221> modified_base <222> (2)..(2) <223> um <220> <221> modified_base <222> (3)..(3) <223> 2'-fluoroguanine <220> <221> modified_base <222> (4)..(4) <223> gm <220> <221> modified_base <222> (5)..(5) <223> 2'-fluorouracil <220> <221> modified_base <222> (6)..(6) <223> cm <220> <221> modified_base <222> (7)..(7) <223> 2'-fluoroadenine <220> <221> modified_base <222> (8)..(8) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (9)..(9) <223> 2'-fluoroadenine <220> <221> modified_base <222> (10)..(10) <223> gm <220> <221> modified_base <222> (11)..(11) <223> 2'-fluorocytosine <220> <221> modified_base <222> (12)..(12) <223> 2'-fluoroadenine <220> <221> modified_base <222> (13)..(13) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (14)..(14) <223> 2'-fluorocytosine <220> <221> modified_base <222> (15)..(15) <223> um <220> <221> modified_base <222> (16)..(16) <223> 2'-fluoroguanine <220> <221> modified_base <222> (17)..(17) <223> gm <220> <221> modified_base <222> (18)..(18) <223> 2'-fluoroadenine <220> <221> modified_base <222> (19)..(19) <223> um <220> <221> modified_base <222> (20)..(20) <223> 2'-fluoroadenine <220> <221> modified_base <222> (21)..(21) <223> cm <400> 1955 cuggucaaag caacuggaua c 21 <210> 1956 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <220> <221> modified_base <222> (1)..(1) <223> 2'-fluoroadenine <220> <221> modified_base <222> (2)..(2) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (3)..(3) <223> 2'-fluoroguanine <220> <221> modified_base <222> (4)..(4) <223> cm <220> <221> modified_base <222> (5)..(5) <223> 2'-fluoroadenine <220> <221> modified_base <222> (6)..(6) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (7)..(7) <223> 2'-fluorocytosine <220> <221> modified_base <222> (8)..(8) <223> um <220> <221> modified_base <222> (9)..(9) <223> 2'-fluoroguanine <220> <221> modified_base <222> (10)..(10) <223> gm <220> <221> modified_base <222> (11)..(11) <223> 2'-fluoroadenine <220> <221> modified_base <222> (12)..(12) <223> 2'-fluorouracil <220> <221> modified_base <222> (13)..(13) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (14)..(14) <223> 2'-fluorocytosine <220> <221> modified_base <222> (15)..(15) <223> um <220> <221> modified_base <222> (16)..(16) <223> 2'-fluoroadenine <220> <221> modified_base <222> (17)..(17) <223> gm <220> <221> modified_base <222> (18)..(18) <223> 2'-fluoroadenine <220> <221> modified_base <222> (19)..(19) <223> um <220> <221> modified_base <222> (20)..(20) <223> 2'-fluorocytosine <220> <221> modified_base <222> (21)..(21) <223> um <400> 1956 aagcaacugg auacuagauc u 21 <210> 1957 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <220> <221> modified_base <222> (1)..(1) <223> 2'-fluoroadenine <220> <221> modified_base <222> (2)..(2) <223> gm <220> <221> modified_base <222> (3)..(3) <223> 2'-fluorocytosine <220> <221> modified_base <222> (4)..(4) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (5)..(5) <223> 2'-fluoroadenine <220> <221> modified_base <222> (6)..(6) <223> cm <220> <221> modified_base <222> (7)..(7) <223> 2'-fluorouracil <220> <221> modified_base <222> (8)..(8) <223> gm <220> <221> modified_base <222> (9)..(9) <223> 2'-fluoroguanine <220> <221> modified_base <222> (10)..(10) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (11)..(11) <223> 2'-fluorouracil <220> <221> modified_base <222> (12)..(12) <223> 2'-fluoroadenine <220> <221> modified_base <222> (13)..(13) <223> cm <220> <221> modified_base <222> (14)..(14) <223> 2'-fluorouracil <220> <221> modified_base <222> (15)..(15) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (16)..(16) <223> 2'-fluoroguanine <220> <221> modified_base <222> (17)..(17) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (18)..(18) <223> 2'-fluorouracil <220> <221> modified_base <222> (19)..(19) <223> cm <220> <221> modified_base <222> (20)..(20) <223> 2'-fluorouracil <220> <221> modified_base <222> (21)..(21) <223> um <400> 1957 agcaacugga uacuagaucu u 21 <210> 1958 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <220> <221> modified_base <222> (1)..(1) <223> 2'-fluoroguanine <220> <221> modified_base <222> (2)..(2) <223> cm <220> <221> modified_base <222> (3)..(3) <223> 2'-fluoroadenine <220> <221> modified_base <222> (4)..(4) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (5)..(5) <223> 2'-fluorocytosine <220> <221> modified_base <222> (6)..(6) <223> um <220> <221> modified_base <222> (7)..(7) <223> 2'-fluoroguanine <220> <221> modified_base <222> (8)..(8) <223> gm <220> <221> modified_base <222> (9)..(9) <223> 2'-fluoroadenine <220> <221> modified_base <222> (10)..(10) <223> um <220> <221> modified_base <222> (11)..(11) <223> 2'-fluoroadenine <220> <221> modified_base <222> (12)..(12) <223> 2'-fluorocytosine <220> <221> modified_base <222> (13)..(13) <223> um <220> <221> modified_base <222> (14)..(14) <223> 2'-fluoroadenine <220> <221> modified_base <222> (15)..(15) <223> gm <220> <221> modified_base <222> (16)..(16) <223> 2'-fluoroadenine <220> <221> modified_base <222> (17)..(17) <223> um <220> <221> modified_base <222> (18)..(18) <223> 2'-fluorocytosine <220> <221> modified_base <222> (19)..(19) <223> um <220> <221> modified_base <222> (20)..(20) <223> 2'-fluorouracil <220> <221> modified_base <222> (21)..(21) <223> 2'-O-methyladenosine <400> 1958 gcaacuggau acuagaucuu a 21 <210> 1959 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <220> <221> modified_base <222> (1)..(1) <223> 2'-fluoroadenine <220> <221> modified_base <222> (2)..(2) <223> um <220> <221> modified_base <222> (3)..(3) <223> 2'-fluorocytosine <220> <221> modified_base <222> (4)..(4) <223> um <220> <221> modified_base <222> (5)..(5) <223> 2'-fluorouracil <220> <221> modified_base <222> (6)..(6) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (7)..(7) <223> 2'-fluorocytosine <220> <221> modified_base <222> (8)..(8) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (9)..(9) <223> 2'-fluorouracil <220> <221> modified_base <222> (10)..(10) <223> cm <220> <221> modified_base <222> (11)..(11) <223> 2'-fluorouracil <220> <221> modified_base <222> (12)..(12) <223> 2'-fluoroguanine <220> <221> modified_base <222> (13)..(13) <223> cm <220> <221> modified_base <222> (14)..(14) <223> 2'-fluoroadenine <220> <221> modified_base <222> (15)..(15) <223> gm <220> <221> modified_base <222> (16)..(16) <223> 2'-fluorocytosine <220> <221> modified_base <222> (17)..(17) <223> um <220> <221> modified_base <222> (18)..(18) <223> 2'-fluorocytosine <220> <221> modified_base <222> (19)..(19) <223> um <220> <221> modified_base <222> (20)..(20) <223> 2'-fluorouracil <220> <221> modified_base <222> (21)..(21) <223> um <400> 1959 aucuuacauc ugcagcucuu u 21 <210> 1960 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <220> <221> modified_base <222> (1)..(1) <223> 2'-fluorouracil <220> <221> modified_base <222> (2)..(2) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (3)..(3) <223> 2'-fluorocytosine <220> <221> modified_base <222> (4)..(4) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (5)..(5) <223> 2'-fluorouracil <220> <221> modified_base <222> (6)..(6) <223> cm <220> <221> modified_base <222> (7)..(7) <223> 2'-fluorouracil <220> <221> modified_base <222> (8)..(8) <223> gm <220> <221> modified_base <222> (9)..(9) <223> 2'-fluorocytosine <220> <221> modified_base <222> (10)..(10) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (11)..(11) <223> 2'-fluoroguanine <220> <221> modified_base <222> (12)..(12) <223> 2'-fluorocytosine <220> <221> modified_base <222> (13)..(13) <223> um <220> <221> modified_base <222> (14)..(14) <223> 2'-fluorocytosine <220> <221> modified_base <222> (15)..(15) <223> um <220> <221> modified_base <222> (16)..(16) <223> 2'-fluorouracil <220> <221> modified_base <222> (17)..(17) <223> um <220> <221> modified_base <222> (18)..(18) <223> 2'-fluorocytosine <220> <221> modified_base <222> (19)..(19) <223> um <220> <221> modified_base <222> (20)..(20) <223> 2'-fluorouracil <220> <221> modified_base <222> (21)..(21) <223> cm <400> 1960 uacaucugca gcucuuucuu c 21 <210> 1961 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <220> <221> modified_base <222> (1)..(1) <223> 2'-fluoroadenine <220> <221> modified_base <222> (2)..(2) <223> cm <220> <221> modified_base <222> (3)..(3) <223> 2'-fluoroadenine <220> <221> modified_base <222> (4)..(4) <223> um <220> <221> modified_base <222> (5)..(5) <223> 2'-fluorocytosine <220> <221> modified_base <222> (6)..(6) <223> um <220> <221> modified_base <222> (7)..(7) <223> 2'-fluoroguanine <220> <221> modified_base <222> (8)..(8) <223> cm <220> <221> modified_base <222> (9)..(9) <223> 2'-fluoroadenine <220> <221> modified_base <222> (10)..(10) <223> gm <220> <221> modified_base <222> (11)..(11) <223> 2'-fluorocytosine <220> <221> modified_base <222> (12)..(12) <223> 2'-fluorouracil <220> <221> modified_base <222> (13)..(13) <223> cm <220> <221> modified_base <222> (14)..(14) <223> 2'-fluorouracil <220> <221> modified_base <222> (15)..(15) <223> um <220> <221> modified_base <222> (16)..(16) <223> 2'-fluorouracil <220> <221> modified_base <222> (17)..(17) <223> cm <220> <221> modified_base <222> (18)..(18) <223> 2'-fluorouracil <220> <221> modified_base <222> (19)..(19) <223> um <220> <221> modified_base <222> (20)..(20) <223> 2'-fluorocytosine <220> <221> modified_base <222> (21)..(21) <223> um <400> 1961 acaucugcag cucuuucuuc u 21 <210> 1962 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <220> <221> modified_base <222> (1)..(1) <223> 2'-fluorocytosine <220> <221> modified_base <222> (2)..(2) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (3)..(3) <223> 2'-fluorouracil <220> <221> modified_base <222> (4)..(4) <223> cm <220> <221> modified_base <222> (5)..(5) <223> 2'-fluorouracil <220> <221> modified_base <222> (6)..(6) <223> gm <220> <221> modified_base <222> (7)..(7) <223> 2'-fluorocytosine <220> <221> modified_base <222> (8)..(8) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (9)..(9) <223> 2'-fluoroguanine <220> <221> modified_base <222> (10)..(10) <223> cm <220> <221> modified_base <222> (11)..(11) <223> 2'-fluorouracil <220> <221> modified_base <222> (12)..(12) <223> 2'-fluorocytosine <220> <221> modified_base <222> (13)..(13) <223> um <220> <221> modified_base <222> (14)..(14) <223> 2'-fluorouracil <220> <221> modified_base <222> (15)..(15) <223> um <220> <221> modified_base <222> (16)..(16) <223> 2'-fluorocytosine <220> <221> modified_base <222> (17)..(17) <223> um <220> <221> modified_base <222> (18)..(18) <223> 2'-fluorouracil <220> <221> modified_base <222> (19)..(19) <223> cm <220> <221> modified_base <222> (20)..(20) <223> 2'-fluorouracil <220> <221> modified_base <222> (21)..(21) <223> um <400> 1962 caucugcagc ucuuucuucu u 21 <210> 1963 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <220> <221> modified_base <222> (1)..(1) <223> 2'-fluoroadenine <220> <221> modified_base <222> (2)..(2) <223> um <220> <221> modified_base <222> (3)..(3) <223> 2'-fluorocytosine <220> <221> modified_base <222> (4)..(4) <223> um <220> <221> modified_base <222> (5)..(5) <223> 2'-fluoroguanine <220> <221> modified_base <222> (6)..(6) <223> cm <220> <221> modified_base <222> (7)..(7) <223> 2'-fluoroadenine <220> <221> modified_base <222> (8)..(8) <223> gm <220> <221> modified_base <222> (9)..(9) <223> 2'-fluorocytosine <220> <221> modified_base <222> (10)..(10) <223> um <220> <221> modified_base <222> (11)..(11) <223> 2'-fluorocytosine <220> <221> modified_base <222> (12)..(12) <223> 2'-fluorouracil <220> <221> modified_base <222> (13)..(13) <223> um <220> <221> modified_base <222> (14)..(14) <223> 2'-fluorouracil <220> <221> modified_base <222> (15)..(15) <223> cm <220> <221> modified_base <222> (16)..(16) <223> 2'-fluorouracil <220> <221> modified_base <222> (17)..(17) <223> um <220> <221> modified_base <222> (18)..(18) <223> 2'-fluorocytosine <220> <221> modified_base <222> (19)..(19) <223> um <220> <221> modified_base <222> (20)..(20) <223> 2'-fluorouracil <220> <221> modified_base <222> (21)..(21) <223> um <400> 1963 aucugcagcu cuuucuucuu u 21 <210> 1964 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <220> <221> modified_base <222> (1)..(1) <223> 2'-fluorouracil <220> <221> modified_base <222> (2)..(2) <223> cm <220> <221> modified_base <222> (3)..(3) <223> 2'-fluorouracil <220> <221> modified_base <222> (4)..(4) <223> gm <220> <221> modified_base <222> (5)..(5) <223> 2'-fluorocytosine <220> <221> modified_base <222> (6)..(6) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (7)..(7) <223> 2'-fluoroguanine <220> <221> modified_base <222> (8)..(8) <223> cm <220> <221> modified_base <222> (9)..(9) <223> 2'-fluorouracil <220> <221> modified_base <222> (10)..(10) <223> cm <220> <221> modified_base <222> (11)..(12) <223> 2'-fluorouracil <220> <221> modified_base <222> (13)..(13) <223> um <220> <221> modified_base <222> (14)..(14) <223> 2'-fluorocytosine <220> <221> modified_base <222> (15)..(15) <223> um <220> <221> modified_base <222> (16)..(16) <223> 2'-fluorouracil <220> <221> modified_base <222> (17)..(17) <223> cm <220> <221> modified_base <222> (18)..(18) <223> 2'-fluorouracil <220> <221> modified_base <222> (19)..(19) <223> um <220> <221> modified_base <222> (20)..(20) <223> 2'-fluorouracil <220> <221> modified_base <222> (21)..(21) <223> gm <400> 1964 ucugcagcuc uuucuucuuu g 21 <210> 1965 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <220> <221> modified_base <222> (1)..(1) <223> 2'-fluorocytosine <220> <221> modified_base <222> (2)..(2) <223> um <220> <221> modified_base <222> (3)..(3) <223> 2'-fluoroguanine <220> <221> modified_base <222> (4)..(4) <223> cm <220> <221> modified_base <222> (5)..(5) <223> 2'-fluoroadenine <220> <221> modified_base <222> (6)..(6) <223> gm <220> <221> modified_base <222> (7)..(7) <223> 2'-fluorocytosine <220> <221> modified_base <222> (8)..(8) <223> um <220> <221> modified_base <222> (9)..(9) <223> 2'-fluorocytosine <220> <221> modified_base <222> (10)..(10) <223> um <220> <221> modified_base <222> (11)..(12) <223> 2'-fluorouracil <220> <221> modified_base <222> (13)..(13) <223> cm <220> <221> modified_base <222> (14)..(14) <223> 2'-fluorouracil <220> <221> modified_base <222> (15)..(15) <223> um <220> <221> modified_base <222> (16)..(16) <223> 2'-fluorocytosine <220> <221> modified_base <222> (17)..(17) <223> um <220> <221> modified_base <222> (18)..(18) <223> 2'-fluorouracil <220> <221> modified_base <222> (19)..(19) <223> um <220> <221> modified_base <222> (20)..(20) <223> 2'-fluoroguanine <220> <221> modified_base <222> (21)..(21) <223> 2'-O-methyladenosine <400> 1965 cugcagcucu uucuucuuug a 21 <210> 1966 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <220> <221> modified_base <222> (1)..(1) <223> 2'-fluorouracil <220> <221> modified_base <222> (2)..(2) <223> gm <220> <221> modified_base <222> (3)..(3) <223> 2'-fluorocytosine <220> <221> modified_base <222> (4)..(4) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (5)..(5) <223> 2'-fluoroguanine <220> <221> modified_base <222> (6)..(6) <223> cm <220> <221> modified_base <222> (7)..(7) <223> 2'-fluorouracil <220> <221> modified_base <222> (8)..(8) <223> cm <220> <221> modified_base <222> (9)..(9) <223> 2'-fluorouracil <220> <221> modified_base <222> (10)..(10) <223> um <220> <221> modified_base <222> (11)..(11) <223> 2'-fluorouracil <220> <221> modified_base <222> (12)..(12) <223> 2'-fluorocytosine <220> <221> modified_base <222> (13)..(13) <223> um <220> <221> modified_base <222> (14)..(14) <223> 2'-fluorouracil <220> <221> modified_base <222> (15)..(15) <223> cm <220> <221> modified_base <222> (16)..(16) <223> 2'-fluorouracil <220> <221> modified_base <222> (17)..(17) <223> um <220> <221> modified_base <222> (18)..(18) <223> 2'-fluorouracil <220> <221> modified_base <222> (19)..(19) <223> gm <220> <221> modified_base <222> (20)..(20) <223> 2'-fluoroadenine <220> <221> modified_base <222> (21)..(21) <223> 2'-O-methyladenosine <400> 1966 ugcagcucuu ucuucuuuga a 21 <210> 1967 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <220> <221> modified_base <222> (1)..(1) <223> 2'-fluoroguanine <220> <221> modified_base <222> (2)..(2) <223> cm <220> <221> modified_base <222> (3)..(3) <223> 2'-fluoroadenine <220> <221> modified_base <222> (4)..(4) <223> gm <220> <221> modified_base <222> (5)..(5) <223> 2'-fluorocytosine <220> <221> modified_base <222> (6)..(6) <223> um <220> <221> modified_base <222> (7)..(7) <223> 2'-fluorocytosine <220> <221> modified_base <222> (8)..(8) <223> um <220> <221> modified_base <222> (9)..(9) <223> 2'-fluorouracil <220> <221> modified_base <222> (10)..(10) <223> um <220> <221> modified_base <222> (11)..(11) <223> 2'-fluorocytosine <220> <221> modified_base <222> (12)..(12) <223> 2'-fluorouracil <220> <221> modified_base <222> (13)..(13) <223> um <220> <221> modified_base <222> (14)..(14) <223> 2'-fluorocytosine <220> <221> modified_base <222> (15)..(15) <223> um <220> <221> modified_base <222> (16)..(16) <223> 2'-fluorouracil <220> <221> modified_base <222> (17)..(17) <223> um <220> <221> modified_base <222> (18)..(18) <223> 2'-fluoroguanine <220> <221> modified_base <222> (19)..(19) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (20)..(20) <223> 2'-fluoroadenine <220> <221> modified_base <222> (21)..(21) <223> um <400> 1967 gcagcucuuu cuucuuugaa u 21 <210> 1968 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <220> <221> modified_base <222> (1)..(1) <223> 2'-fluorocytosine <220> <221> modified_base <222> (2)..(2) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (3)..(3) <223> 2'-fluoroguanine <220> <221> modified_base <222> (4)..(4) <223> cm <220> <221> modified_base <222> (5)..(5) <223> 2'-fluorouracil <220> <221> modified_base <222> (6)..(6) <223> cm <220> <221> modified_base <222> (7)..(7) <223> 2'-fluorouracil <220> <221> modified_base <222> (8)..(8) <223> um <220> <221> modified_base <222> (9)..(9) <223> 2'-fluorouracil <220> <221> modified_base <222> (10)..(10) <223> cm <220> <221> modified_base <222> (11)..(12) <223> 2'-fluorouracil <220> <221> modified_base <222> (13)..(13) <223> cm <220> <221> modified_base <222> (14)..(14) <223> 2'-fluorouracil <220> <221> modified_base <222> (15)..(15) <223> um <220> <221> modified_base <222> (16)..(16) <223> 2'-fluorouracil <220> <221> modified_base <222> (17)..(17) <223> gm <220> <221> modified_base <222> (18)..(18) <223> 2'-fluoroadenine <220> <221> modified_base <222> (19)..(19) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (20)..(20) <223> 2'-fluorouracil <220> <221> modified_base <222> (21)..(21) <223> um <400> 1968 cagcucuuuc uucuuugaau u 21 <210> 1969 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <220> <221> modified_base <222> (1)..(1) <223> 2'-fluorouracil <220> <221> modified_base <222> (2)..(2) <223> um <220> <221> modified_base <222> (3)..(3) <223> 2'-fluoroguanine <220> <221> modified_base <222> (4)..(4) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (5)..(5) <223> 2'-fluoroadenine <220> <221> modified_base <222> (6)..(6) <223> um <220> <221> modified_base <222> (7)..(7) <223> 2'-fluorouracil <220> <221> modified_base <222> (8)..(8) <223> um <220> <221> modified_base <222> (9)..(9) <223> 2'-fluorocytosine <220> <221> modified_base <222> (10)..(10) <223> cm <220> <221> modified_base <222> (11)..(11) <223> 2'-fluorouracil <220> <221> modified_base <222> (12)..(12) <223> 2'-fluoroadenine <220> <221> modified_base <222> (13)..(13) <223> um <220> <221> modified_base <222> (14)..(14) <223> 2'-fluorocytosine <220> <221> modified_base <222> (15)..(15) <223> um <220> <221> modified_base <222> (16)..(16) <223> 2'-fluoroguanine <220> <221> modified_base <222> (17)..(17) <223> um <220> <221> modified_base <222> (18)..(18) <223> 2'-fluoroadenine <220> <221> modified_base <222> (19)..(19) <223> um <220> <221> modified_base <222> (20)..(20) <223> 2'-fluoroguanine <220> <221> modified_base <222> (21)..(21) <223> um <400> 1969 uugaauuucc uaucuguaug u 21 <210> 1970 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <220> <221> modified_base <222> (1)..(1) <223> 2'-fluorouracil <220> <221> modified_base <222> (2)..(2) <223> cm <220> <221> modified_base <222> (3)..(3) <223> 2'-fluorocytosine <220> <221> modified_base <222> (4)..(4) <223> um <220> <221> modified_base <222> (5)..(5) <223> 2'-fluoroadenine <220> <221> modified_base <222> (6)..(6) <223> um <220> <221> modified_base <222> (7)..(7) <223> 2'-fluorocytosine <220> <221> modified_base <222> (8)..(8) <223> um <220> <221> modified_base <222> (9)..(9) <223> 2'-fluoroguanine <220> <221> modified_base <222> (10)..(10) <223> um <220> <221> modified_base <222> (11)..(11) <223> 2'-fluoroadenine <220> <221> modified_base <222> (12)..(12) <223> 2'-fluorouracil <220> <221> modified_base <222> (13)..(13) <223> gm <220> <221> modified_base <222> (14)..(14) <223> 2'-fluorouracil <220> <221> modified_base <222> (15)..(15) <223> cm <220> <221> modified_base <222> (16)..(16) <223> 2'-fluorouracil <220> <221> modified_base <222> (17)..(17) <223> gm <220> <221> modified_base <222> (18)..(18) <223> 2'-fluorocytosine <220> <221> modified_base <222> (19)..(19) <223> cm <220> <221> modified_base <222> (20)..(20) <223> 2'-fluorouracil <220> <221> modified_base <222> (21)..(21) <223> 2'-O-methyladenosine <400> 1970 uccuaucugu augucugccu a 21 <210> 1971 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <220> <221> modified_base <222> (1)..(1) <223> 2'-fluoroadenine <220> <221> modified_base <222> (2)..(2) <223> um <220> <221> modified_base <222> (3)..(3) <223> 2'-fluorocytosine <220> <221> modified_base <222> (4)..(4) <223> um <220> <221> modified_base <222> (5)..(5) <223> 2'-fluoroguanine <220> <221> modified_base <222> (6)..(6) <223> um <220> <221> modified_base <222> (7)..(7) <223> 2'-fluoroadenine <220> <221> modified_base <222> (8)..(8) <223> um <220> <221> modified_base <222> (9)..(9) <223> 2'-fluoroguanine <220> <221> modified_base <222> (10)..(10) <223> um <220> <221> modified_base <222> (11)..(11) <223> 2'-fluorocytosine <220> <221> modified_base <222> (12)..(12) <223> 2'-fluorouracil <220> <221> modified_base <222> (13)..(13) <223> gm <220> <221> modified_base <222> (14)..(14) <223> 2'-fluorocytosine <220> <221> modified_base <222> (15)..(15) <223> cm <220> <221> modified_base <222> (16)..(16) <223> 2'-fluorouracil <220> <221> modified_base <222> (17)..(17) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (18)..(18) <223> 2'-fluoroadenine <220> <221> modified_base <222> (19)..(19) <223> um <220> <221> modified_base <222> (20)..(20) <223> 2'-fluorouracil <220> <221> modified_base <222> (21)..(21) <223> 2'-O-methyladenosine <400> 1971 aucuguaugu cugccuaauu a 21 <210> 1972 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <220> <221> modified_base <222> (1)..(1) <223> 2'-fluorouracil <220> <221> modified_base <222> (2)..(2) <223> cm <220> <221> modified_base <222> (3)..(3) <223> 2'-fluorouracil <220> <221> modified_base <222> (4)..(4) <223> gm <220> <221> modified_base <222> (5)..(5) <223> 2'-fluorouracil <220> <221> modified_base <222> (6)..(6) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (7)..(7) <223> 2'-fluorouracil <220> <221> modified_base <222> (8)..(8) <223> gm <220> <221> modified_base <222> (9)..(9) <223> 2'-fluorouracil <220> <221> modified_base <222> (10)..(10) <223> cm <220> <221> modified_base <222> (11)..(11) <223> 2'-fluorouracil <220> <221> modified_base <222> (12)..(12) <223> 2'-fluoroguanine <220> <221> modified_base <222> (13)..(13) <223> cm <220> <221> modified_base <222> (14)..(14) <223> 2'-fluorocytosine <220> <221> modified_base <222> (15)..(15) <223> um <220> <221> modified_base <222> (16)..(16) <223> 2'-fluoroadenine <220> <221> modified_base <222> (17)..(17) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (18)..(18) <223> 2'-fluorouracil <220> <221> modified_base <222> (19)..(19) <223> um <220> <221> modified_base <222> (20)..(20) <223> 2'-fluoroadenine <220> <221> modified_base <222> (21)..(21) <223> 2'-O-methyladenosine <400> 1972 ucuguauguc ugccuaauua a 21 <210> 1973 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <220> <221> modified_base <222> (1)..(1) <223> 2'-fluorocytosine <220> <221> modified_base <222> (2)..(2) <223> um <220> <221> modified_base <222> (3)..(3) <223> 2'-fluoroguanine <220> <221> modified_base <222> (4)..(4) <223> um <220> <221> modified_base <222> (5)..(5) <223> 2'-fluoroadenine <220> <221> modified_base <222> (6)..(6) <223> um <220> <221> modified_base <222> (7)..(7) <223> 2'-fluoroguanine <220> <221> modified_base <222> (8)..(8) <223> um <220> <221> modified_base <222> (9)..(9) <223> 2'-fluorocytosine <220> <221> modified_base <222> (10)..(10) <223> um <220> <221> modified_base <222> (11)..(11) <223> 2'-fluoroguanine <220> <221> modified_base <222> (12)..(12) <223> 2'-fluorocytosine <220> <221> modified_base <222> (13)..(13) <223> cm <220> <221> modified_base <222> (14)..(14) <223> 2'-fluorouracil <220> <221> modified_base <222> (15)..(15) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (16)..(16) <223> 2'-fluoroadenine <220> <221> modified_base <222> (17)..(17) <223> um <220> <221> modified_base <222> (18)..(18) <223> 2'-fluorouracil <220> <221> modified_base <222> (19)..(19) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (20)..(20) <223> 2'-fluoroadenine <220> <221> modified_base <222> (21)..(21) <223> 2'-O-methyladenosine <400> 1973 cuguaugucu gccuaauuaa a 21 <210> 1974 <211> 21 <212> RNA <213> Artificial Sequence <220> <223> siRNA sense strand against APCS <220> <221> modified_base <222> (1)..(1) <223> 2'-fluoroguanine <220> <221> modified_base <222> (2)..(2) <223> um <220> <221> modified_base <222> (3)..(3) <223> 2'-fluorocytosine <220> <221> modified_base <222> (4)..(4) <223> um <220> <221> modified_base <222> (5)..(5) <223> 2'-fluoroguanine <220> <221> modified_base <222> (6)..(6) <223> cm <220> <221> modified_base <222> (7)..(7) <223> 2'-fluorocytosine <220> <221> modified_base <222> (8)..(8) <223> um <220> <221> modified_base <222> (9)..(9) <223> 2'-fluoroadenine <220> <221> modified_base <222> (10)..(10) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (11)..(12) <223> 2'-fluorouracil <220> <221> modified_base <222> (13)..(13) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (14)..(14) <223> 2'-fluoroadenine <220> <221> modified_base <222> (15)..(15) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (16)..(16) <223> 2'-fluoroadenine <220> <221> modified_base <222> (17)..(17) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (18)..(18) <223> 2'-fluoroadenine <220> <221> modified_base <222> (19)..(19) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (20)..(20) <223> 2'-fluorouracil <220> <221> modified_base <222> (21)..(21) <223> 2'-O-methyladenosine <400> 1974 gucugccuaa uuaaaaaaau a 21 <210> 1975 <211> 23 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <220> <221> modified_base <222> (1)..(1) <223> 2'-fluorouracil <220> <221> modified_base <222> (2)..(2) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (3)..(3) <223> 2'-fluoroguanine <220> <221> modified_base <222> (4)..(4) <223> gm <220> <221> modified_base <222> (5)..(5) <223> 2'-fluorocytosine <220> <221> modified_base <222> (6)..(6) <223> um <220> <221> modified_base <222> (7)..(7) <223> 2'-fluorocytosine <220> <221> modified_base <222> (8)..(8) <223> gm <220> <221> modified_base <222> (9)..(9) <223> 2'-fluoroadenine <220> <221> modified_base <222> (10)..(11) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (12)..(12) <223> 2'-fluoroadenine <220> <221> modified_base <222> (13)..(13) <223> cm <220> <221> modified_base <222> (14)..(14) <223> 2'-fluoroadenine <220> <221> modified_base <222> (15)..(15) <223> cm <220> <221> modified_base <222> (16)..(16) <223> 2'-fluoroadenine <220> <221> modified_base <222> (17)..(17) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (18)..(18) <223> 2'-fluoroguanine <220> <221> modified_base <222> (19)..(19) <223> gm <220> <221> modified_base <222> (20)..(20) <223> 2'-fluorouracil <220> <221> modified_base <222> (21)..(21) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (22)..(22) <223> 2'-fluoroadenine <220> <221> modified_base <222> (23)..(23) <223> 2'-O-methyladenosine <400> 1975 uaggcucgaa aacacaaggu aaa 23 <210> 1976 <211> 23 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <220> <221> modified_base <222> (1)..(1) <223> 2'-fluorouracil <220> <221> modified_base <222> (2)..(2) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (3)..(3) <223> 2'-fluoroguanine <220> <221> modified_base <222> (4)..(4) <223> gm <220> <221> modified_base <222> (5)..(5) <223> 2'-fluoroadenine <220> <221> modified_base <222> (6)..(6) <223> gm <220> <221> modified_base <222> (7)..(7) <223> 2'-fluoroadenine <220> <221> modified_base <222> (8)..(8) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (9)..(9) <223> 2'-fluoroguanine <220> <221> modified_base <222> (10)..(10) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (11)..(11) <223> gm <220> <221> modified_base <222> (12)..(12) <223> 2'-fluoroguanine <220> <221> modified_base <222> (13)..(13) <223> cm <220> <221> modified_base <222> (14)..(14) <223> 2'-fluorouracil <220> <221> modified_base <222> (15)..(15) <223> gm <220> <221> modified_base <222> (16)..(16) <223> 2'-fluorouracil <220> <221> modified_base <222> (17)..(17) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (18)..(18) <223> 2'-fluoroguanine <220> <221> modified_base <222> (19)..(19) <223> gm <220> <221> modified_base <222> (20)..(20) <223> 2'-fluorocytosine <220> <221> modified_base <222> (21)..(21) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (22)..(22) <223> 2'-fluorocytosine <220> <221> modified_base <222> (23)..(23) <223> gm <400> 1976 uaggagaaga ggcuguaggc acg 23 <210> 1977 <211> 23 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <220> <221> modified_base <222> (1)..(1) <223> 2'-fluorouracil <220> <221> modified_base <222> (2)..(2) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (3)..(3) <223> 2'-fluorouracil <220> <221> modified_base <222> (4)..(4) <223> um <220> <221> modified_base <222> (5)..(5) <223> 2'-fluoroguanine <220> <221> modified_base <222> (6)..(6) <223> um <220> <221> modified_base <222> (7)..(7) <223> 2'-fluoroadenine <220> <221> modified_base <222> (8)..(8) <223> gm <220> <221> modified_base <222> (9)..(9) <223> 2'-fluoroguanine <220> <221> modified_base <222> (10)..(10) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (11)..(11) <223> gm <220> <221> modified_base <222> (12)..(12) <223> 2'-fluoroadenine <220> <221> modified_base <222> (13)..(13) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (14)..(14) <223> 2'-fluoroguanine <220> <221> modified_base <222> (15)..(15) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (16)..(16) <223> 2'-fluoroguanine <220> <221> modified_base <222> (17)..(17) <223> gm <220> <221> modified_base <222> (18)..(18) <223> 2'-fluorocytosine <220> <221> modified_base <222> (19)..(19) <223> um <220> <221> modified_base <222> (20)..(20) <223> 2'-fluoroguanine <220> <221> modified_base <222> (21)..(21) <223> um <220> <221> modified_base <222> (22)..(22) <223> 2'-fluoroadenine <220> <221> modified_base <222> (23)..(23) <223> gm <400> 1977 uauuguagga gaagaggcug uag 23 <210> 1978 <211> 23 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <220> <221> modified_base <222> (1)..(1) <223> 2'-fluorouracil <220> <221> modified_base <222> (2)..(2) <223> cm <220> <221> modified_base <222> (3)..(3) <223> 2'-fluoroadenine <220> <221> modified_base <222> (4)..(4) <223> gm <220> <221> modified_base <222> (5)..(5) <223> 2'-fluorocytosine <220> <221> modified_base <222> (6)..(6) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (7)..(7) <223> 2'-fluoroadenine <220> <221> modified_base <222> (8)..(8) <223> um <220> <221> modified_base <222> (9)..(9) <223> 2'-fluoroadenine <220> <221> modified_base <222> (10)..(11) <223> cm <220> <221> modified_base <222> (12)..(12) <223> 2'-fluorouracil <220> <221> modified_base <222> (13)..(13) <223> gm <220> <221> modified_base <222> (14)..(14) <223> 2'-fluoroadenine <220> <221> modified_base <222> (15)..(15) <223> um <220> <221> modified_base <222> (16)..(16) <223> 2'-fluoroguanine <220> <221> modified_base <222> (17)..(17) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (18)..(18) <223> 2'-fluoroguanine <220> <221> modified_base <222> (19)..(19) <223> gm <220> <221> modified_base <222> (20)..(20) <223> 2'-fluoroadenine <220> <221> modified_base <222> (21)..(21) <223> cm <220> <221> modified_base <222> (22)..(22) <223> 2'-fluorouracil <220> <221> modified_base <222> (23)..(23) <223> cm <400> 1978 ucagcaauac cugaugagga cuc 23 <210> 1979 <211> 23 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <220> <221> modified_base <222> (1)..(1) <223> 2'-fluorouracil <220> <221> modified_base <222> (2)..(2) <223> cm <220> <221> modified_base <222> (3)..(3) <223> 2'-fluorocytosine <220> <221> modified_base <222> (4)..(4) <223> cm <220> <221> modified_base <222> (5)..(5) <223> 2'-fluoroadenine <220> <221> modified_base <222> (6)..(6) <223> cm <220> <221> modified_base <222> (7)..(7) <223> 2'-fluoroadenine <220> <221> modified_base <222> (8)..(8) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (9)..(9) <223> 2'-fluoroadenine <220> <221> modified_base <222> (10)..(11) <223> gm <220> <221> modified_base <222> (12)..(12) <223> 2'-fluoroadenine <220> <221> modified_base <222> (13)..(13) <223> cm <220> <221> modified_base <222> (14)..(14) <223> 2'-fluorouracil <220> <221> modified_base <222> (15)..(15) <223> gm <220> <221> modified_base <222> (16)..(16) <223> 2'-fluoroguanine <220> <221> modified_base <222> (17)..(17) <223> cm <220> <221> modified_base <222> (18)..(18) <223> 2'-fluorouracil <220> <221> modified_base <222> (19)..(19) <223> cm <220> <221> modified_base <222> (20)..(20) <223> 2'-fluorocytosine <220> <221> modified_base <222> (21)..(21) <223> um <220> <221> modified_base <222> (22)..(22) <223> 2'-fluoroadenine <220> <221> modified_base <222> (23)..(23) <223> um <400> 1979 ucccacaaag gacuggcucc uau 23 <210> 1980 <211> 23 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <220> <221> modified_base <222> (1)..(1) <223> 2'-fluorouracil <220> <221> modified_base <222> (2)..(2) <223> cm <220> <221> modified_base <222> (3)..(3) <223> 2'-fluorouracil <220> <221> modified_base <222> (4)..(4) <223> cm <220> <221> modified_base <222> (5)..(5) <223> 2'-fluorocytosine <220> <221> modified_base <222> (6)..(6) <223> cm <220> <221> modified_base <222> (7)..(7) <223> 2'-fluoroadenine <220> <221> modified_base <222> (8)..(8) <223> cm <220> <221> modified_base <222> (9)..(9) <223> 2'-fluoroadenine <220> <221> modified_base <222> (10)..(11) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (12)..(12) <223> 2'-fluoroguanine <220> <221> modified_base <222> (13)..(13) <223> gm <220> <221> modified_base <222> (14)..(14) <223> 2'-fluoroadenine <220> <221> modified_base <222> (15)..(15) <223> cm <220> <221> modified_base <222> (16)..(16) <223> 2'-fluorouracil <220> <221> modified_base <222> (17)..(17) <223> gm <220> <221> modified_base <222> (18)..(18) <223> 2'-fluoroguanine <220> <221> modified_base <222> (19)..(19) <223> cm <220> <221> modified_base <222> (20)..(20) <223> 2'-fluorouracil <220> <221> modified_base <222> (21)..(21) <223> cm <220> <221> modified_base <222> (22)..(22) <223> 2'-fluorocytosine <220> <221> modified_base <222> (23)..(23) <223> um <400> 1980 ucucccacaa aggacuggcu ccu 23 <210> 1981 <211> 23 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <220> <221> modified_base <222> (1)..(1) <223> 2'-fluoroadenine <220> <221> modified_base <222> (2)..(2) <223> um <220> <221> modified_base <222> (3)..(3) <223> 2'-fluorocytosine <220> <221> modified_base <222> (4)..(4) <223> um <220> <221> modified_base <222> (5)..(5) <223> 2'-fluorocytosine <220> <221> modified_base <222> (6)..(6) <223> um <220> <221> modified_base <222> (7)..(7) <223> 2'-fluorocytosine <220> <221> modified_base <222> (8)..(8) <223> cm <220> <221> modified_base <222> (9)..(9) <223> 2'-fluorocytosine <220> <221> modified_base <222> (10)..(10) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (11)..(11) <223> cm <220> <221> modified_base <222> (12)..(12) <223> 2'-fluoroadenine <220> <221> modified_base <222> (13)..(13) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (14)..(14) <223> 2'-fluoroadenine <220> <221> modified_base <222> (15)..(15) <223> gm <220> <221> modified_base <222> (16)..(16) <223> 2'-fluoroguanine <220> <221> modified_base <222> (17)..(17) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (18)..(18) <223> 2'-fluorocytosine <220> <221> modified_base <222> (19)..(19) <223> um <220> <221> modified_base <222> (20)..(20) <223> 2'-fluoroguanine <220> <221> modified_base <222> (21)..(21) <223> gm <220> <221> modified_base <222> (22)..(22) <223> 2'-fluorocytosine <220> <221> modified_base <222> (23)..(23) <223> um <400> 1981 aucucuccca caaaggacug gcu 23 <210> 1982 <211> 23 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <220> <221> modified_base <222> (1)..(1) <223> 2'-fluoroadenine <220> <221> modified_base <222> (2)..(2) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (3)..(3) <223> 2'-fluorouracil <220> <221> modified_base <222> (4)..(4) <223> cm <220> <221> modified_base <222> (5)..(5) <223> 2'-fluorouracil <220> <221> modified_base <222> (6)..(6) <223> cm <220> <221> modified_base <222> (7)..(7) <223> 2'-fluorouracil <220> <221> modified_base <222> (8)..(8) <223> cm <220> <221> modified_base <222> (9)..(9) <223> 2'-fluorocytosine <220> <221> modified_base <222> (10)..(10) <223> cm <220> <221> modified_base <222> (11)..(11) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (12)..(12) <223> 2'-fluorocytosine <220> <221> modified_base <222> (13)..(13) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (14)..(14) <223> 2'-fluoroadenine <220> <221> modified_base <222> (15)..(15) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (16)..(16) <223> 2'-fluoroguanine <220> <221> modified_base <222> (17)..(17) <223> gm <220> <221> modified_base <222> (18)..(18) <223> 2'-fluoroadenine <220> <221> modified_base <222> (19)..(19) <223> cm <220> <221> modified_base <222> (20)..(20) <223> 2'-fluorouracil <220> <221> modified_base <222> (21)..(21) <223> gm <220> <221> modified_base <222> (22)..(22) <223> 2'-fluoroguanine <220> <221> modified_base <222> (23)..(23) <223> cm <400> 1982 aaucucuccc acaaaggacu ggc 23 <210> 1983 <211> 23 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <220> <221> modified_base <222> (1)..(1) <223> 2'-fluoroadenine <220> <221> modified_base <222> (2)..(2) <223> cm <220> <221> modified_base <222> (3)..(3) <223> 2'-fluoroadenine <220> <221> modified_base <222> (4)..(4) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (5)..(5) <223> 2'-fluoroadenine <220> <221> modified_base <222> (6)..(6) <223> um <220> <221> modified_base <222> (7)..(7) <223> 2'-fluorocytosine <220> <221> modified_base <222> (8)..(8) <223> cm <220> <221> modified_base <222> (9)..(9) <223> 2'-fluorocytosine <220> <221> modified_base <222> (10)..(10) <223> cm <220> <221> modified_base <222> (11)..(11) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (12)..(12) <223> 2'-fluoroadenine <220> <221> modified_base <222> (13)..(13) <223> um <220> <221> modified_base <222> (14)..(14) <223> 2'-fluorocytosine <220> <221> modified_base <222> (15)..(15) <223> um <220> <221> modified_base <222> (16)..(16) <223> 2'-fluorocytosine <220> <221> modified_base <222> (17)..(17) <223> um <220> <221> modified_base <222> (18)..(18) <223> 2'-fluorocytosine <220> <221> modified_base <222> (19)..(19) <223> cm <220> <221> modified_base <222> (20)..(20) <223> 2'-fluorocytosine <220> <221> modified_base <222> (21)..(21) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (22)..(22) <223> 2'-fluorocytosine <220> <221> modified_base <222> (23)..(23) <223> 2'-O-methyladenosine <400> 1983 acaaaucccc aaucucuccc aca 23 <210> 1984 <211> 23 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <220> <221> modified_base <222> (1)..(1) <223> 2'-fluorouracil <220> <221> modified_base <222> (2)..(2) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (3)..(3) <223> 2'-fluorocytosine <220> <221> modified_base <222> (4)..(4) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (5)..(5) <223> 2'-fluoroadenine <220> <221> modified_base <222> (6)..(6) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (7)..(7) <223> 2'-fluorouracil <220> <221> modified_base <222> (8)..(8) <223> cm <220> <221> modified_base <222> (9)..(9) <223> 2'-fluorocytosine <220> <221> modified_base <222> (10)..(11) <223> cm <220> <221> modified_base <222> (12)..(12) <223> 2'-fluoroadenine <220> <221> modified_base <222> (13)..(13) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (14)..(14) <223> 2'-fluorouracil <220> <221> modified_base <222> (15)..(15) <223> cm <220> <221> modified_base <222> (16)..(16) <223> 2'-fluorouracil <220> <221> modified_base <222> (17)..(17) <223> cm <220> <221> modified_base <222> (18)..(18) <223> 2'-fluorouracil <220> <221> modified_base <222> (19)..(19) <223> cm <220> <221> modified_base <222> (20)..(20) <223> 2'-fluorocytosine <220> <221> modified_base <222> (21)..(21) <223> cm <220> <221> modified_base <222> (22)..(22) <223> 2'-fluoroadenine <220> <221> modified_base <222> (23)..(23) <223> cm <400> 1984 uacaaauccc caaucucucc cac 23 <210> 1985 <211> 23 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <220> <221> modified_base <222> (1)..(1) <223> 2'-fluorouracil <220> <221> modified_base <222> (2)..(2) <223> gm <220> <221> modified_base <222> (3)..(3) <223> 2'-fluorouracil <220> <221> modified_base <222> (4)..(4) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (5)..(5) <223> 2'-fluorocytosine <220> <221> modified_base <222> (6)..(6) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (7)..(7) <223> 2'-fluoroadenine <220> <221> modified_base <222> (8)..(8) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (9)..(9) <223> 2'-fluorouracil <220> <221> modified_base <222> (10)..(11) <223> cm <220> <221> modified_base <222> (12)..(12) <223> 2'-fluorocytosine <220> <221> modified_base <222> (13)..(13) <223> cm <220> <221> modified_base <222> (14)..(14) <223> 2'-fluoroadenine <220> <221> modified_base <222> (15)..(15) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (16)..(16) <223> 2'-fluorouracil <220> <221> modified_base <222> (17)..(17) <223> cm <220> <221> modified_base <222> (18)..(18) <223> 2'-fluorouracil <220> <221> modified_base <222> (19)..(19) <223> cm <220> <221> modified_base <222> (20)..(20) <223> 2'-fluorouracil <220> <221> modified_base <222> (21)..(21) <223> cm <220> <221> modified_base <222> (22)..(22) <223> 2'-fluorocytosine <220> <221> modified_base <222> (23)..(23) <223> cm <400> 1985 uguacaaauc cccaaucucu ccc 23 <210> 1986 <211> 23 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <220> <221> modified_base <222> (1)..(1) <223> 2'-fluorouracil <220> <221> modified_base <222> (2)..(2) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (3)..(3) <223> 2'-fluorocytosine <220> <221> modified_base <222> (4)..(4) <223> cm <220> <221> modified_base <222> (5)..(5) <223> 2'-fluorocytosine <220> <221> modified_base <222> (6)..(6) <223> um <220> <221> modified_base <222> (7)..(7) <223> 2'-fluoroguanine <220> <221> modified_base <222> (8)..(8) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (9)..(9) <223> 2'-fluorouracil <220> <221> modified_base <222> (10)..(10) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (11)..(11) <223> gm <220> <221> modified_base <222> (12)..(12) <223> 2'-fluoroguanine <220> <221> modified_base <222> (13)..(13) <223> cm <220> <221> modified_base <222> (14)..(14) <223> 2'-fluoroadenine <220> <221> modified_base <222> (15)..(15) <223> gm <220> <221> modified_base <222> (16)..(16) <223> 2'-fluoroadenine <220> <221> modified_base <222> (17)..(17) <223> cm <220> <221> modified_base <222> (18)..(18) <223> 2'-fluoroadenine <220> <221> modified_base <222> (19)..(19) <223> gm <220> <221> modified_base <222> (20)..(20) <223> 2'-fluoroguanine <220> <221> modified_base <222> (21)..(21) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (22)..(22) <223> 2'-fluorouracil <220> <221> modified_base <222> (23)..(23) <223> 2'-O-methyladenosine <400> 1986 uacccugaua ggcagacagg aua 23 <210> 1987 <211> 23 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <220> <221> modified_base <222> (1)..(1) <223> 2'-fluoroguanine <220> <221> modified_base <222> (2)..(2) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (3)..(3) <223> 2'-fluorouracil <220> <221> modified_base <222> (4)..(4) <223> um <220> <221> modified_base <222> (5)..(5) <223> 2'-fluorouracil <220> <221> modified_base <222> (6)..(6) <223> cm <220> <221> modified_base <222> (7)..(7) <223> 2'-fluoroadenine <220> <221> modified_base <222> (8)..(8) <223> um <220> <221> modified_base <222> (9)..(9) <223> 2'-fluoroadenine <220> <221> modified_base <222> (10)..(10) <223> gm <220> <221> modified_base <222> (11)..(11) <223> um <220> <221> modified_base <222> (12)..(12) <223> 2'-fluorouracil <220> <221> modified_base <222> (13)..(13) <223> cm <220> <221> modified_base <222> (14)..(14) <223> 2'-fluoroadenine <220> <221> modified_base <222> (15)..(15) <223> gm <220> <221> modified_base <222> (16)..(16) <223> 2'-fluoroadenine <220> <221> modified_base <222> (17)..(17) <223> gm <220> <221> modified_base <222> (18)..(18) <223> 2'-fluorocytosine <220> <221> modified_base <222> (19)..(19) <223> cm <220> <221> modified_base <222> (20)..(20) <223> 2'-fluorouracil <220> <221> modified_base <222> (21)..(21) <223> gm <220> <221> modified_base <222> (22)..(22) <223> 2'-fluorocytosine <220> <221> modified_base <222> (23)..(23) <223> cm <400> 1987 gauuucauag uucagagccu gcc 23 <210> 1988 <211> 23 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <220> <221> modified_base <222> (1)..(1) <223> 2'-fluoroguanine <220> <221> modified_base <222> (2)..(2) <223> um <220> <221> modified_base <222> (3)..(3) <223> 2'-fluorouracil <220> <221> modified_base <222> (4)..(4) <223> um <220> <221> modified_base <222> (5)..(5) <223> 2'-fluoroguanine <220> <221> modified_base <222> (6)..(6) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (7)..(7) <223> 2'-fluorouracil <220> <221> modified_base <222> (8)..(8) <223> gm <220> <221> modified_base <222> (9)..(9) <223> 2'-fluoroadenine <220> <221> modified_base <222> (10)..(10) <223> um <220> <221> modified_base <222> (11)..(11) <223> gm <220> <221> modified_base <222> (12)..(12) <223> 2'-fluoroadenine <220> <221> modified_base <222> (13)..(13) <223> cm <220> <221> modified_base <222> (14)..(14) <223> 2'-fluoroadenine <220> <221> modified_base <222> (15)..(15) <223> um <220> <221> modified_base <222> (16)..(16) <223> 2'-fluoroadenine <220> <221> modified_base <222> (17)..(17) <223> um <220> <221> modified_base <222> (18)..(18) <223> 2'-fluorocytosine <220> <221> modified_base <222> (19)..(19) <223> cm <220> <221> modified_base <222> (20)..(20) <223> 2'-fluorouracil <220> <221> modified_base <222> (21)..(21) <223> cm <220> <221> modified_base <222> (22)..(22) <223> 2'-fluorouracil <220> <221> modified_base <222> (23)..(23) <223> gm <400> 1988 guuugaugau gacauauccu cug 23 <210> 1989 <211> 23 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <220> <221> modified_base <222> (1)..(1) <223> 2'-fluorouracil <220> <221> modified_base <222> (2)..(2) <223> gm <220> <221> modified_base <222> (3)..(3) <223> 2'-fluoroadenine <220> <221> modified_base <222> (4)..(4) <223> gm <220> <221> modified_base <222> (5)..(5) <223> 2'-fluorouracil <220> <221> modified_base <222> (6)..(6) <223> cm <220> <221> modified_base <222> (7)..(7) <223> 2'-fluoroadenine <220> <221> modified_base <222> (8)..(8) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (9)..(9) <223> 2'-fluoroguanine <220> <221> modified_base <222> (10)..(10) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (11)..(11) <223> cm <220> <221> modified_base <222> (12)..(12) <223> 2'-fluorocytosine <220> <221> modified_base <222> (13)..(13) <223> um <220> <221> modified_base <222> (14)..(14) <223> 2'-fluorocytosine <220> <221> modified_base <222> (15)..(15) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (16)..(16) <223> 2'-fluoroguanine <220> <221> modified_base <222> (17)..(17) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (18)..(18) <223> 2'-fluorocytosine <220> <221> modified_base <222> (19)..(19) <223> cm <220> <221> modified_base <222> (20)..(20) <223> 2'-fluorocytosine <220> <221> modified_base <222> (21)..(21) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (22)..(22) <223> 2'-fluorocytosine <220> <221> modified_base <222> (23)..(23) <223> 2'-O-methyladenosine <400> 1989 ugagucaaga ccucagaccc aca 23 <210> 1990 <211> 23 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <220> <221> modified_base <222> (1)..(1) <223> 2'-fluorouracil <220> <221> modified_base <222> (2)..(2) <223> um <220> <221> modified_base <222> (3)..(3) <223> 2'-fluorouracil <220> <221> modified_base <222> (4)..(4) <223> cm <220> <221> modified_base <222> (5)..(5) <223> 2'-fluoroadenine <220> <221> modified_base <222> (6)..(6) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (7)..(7) <223> 2'-fluoroguanine <220> <221> modified_base <222> (8)..(8) <223> um <220> <221> modified_base <222> (9)..(9) <223> 2'-fluoroguanine <220> <221> modified_base <222> (10)..(10) <223> cm <220> <221> modified_base <222> (11)..(11) <223> um <220> <221> modified_base <222> (12)..(12) <223> 2'-fluorocytosine <220> <221> modified_base <222> (13)..(13) <223> um <220> <221> modified_base <222> (14)..(14) <223> 2'-fluorocytosine <220> <221> modified_base <222> (15)..(15) <223> gm <220> <221> modified_base <222> (16)..(16) <223> 2'-fluorouracil <220> <221> modified_base <222> (17)..(17) <223> um <220> <221> modified_base <222> (18)..(18) <223> 2'-fluoroguanine <220> <221> modified_base <222> (19)..(19) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (20)..(20) <223> 2'-fluoroguanine <220> <221> modified_base <222> (21)..(21) <223> um <220> <221> modified_base <222> (22)..(22) <223> 2'-fluorocytosine <220> <221> modified_base <222> (23)..(23) <223> 2'-O-methyladenosine <400> 1990 uuucaagugc ucucguugag uca 23 <210> 1991 <211> 23 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <220> <221> modified_base <222> (1)..(1) <223> 2'-fluorouracil <220> <221> modified_base <222> (2)..(2) <223> um <220> <221> modified_base <222> (3)..(3) <223> 2'-fluorouracil <220> <221> modified_base <222> (4)..(4) <223> um <220> <221> modified_base <222> (5)..(5) <223> 2'-fluorocytosine <220> <221> modified_base <222> (6)..(6) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (7)..(7) <223> 2'-fluoroadenine <220> <221> modified_base <222> (8)..(8) <223> gm <220> <221> modified_base <222> (9)..(9) <223> 2'-fluorouracil <220> <221> modified_base <222> (10)..(10) <223> gm <220> <221> modified_base <222> (11)..(11) <223> cm <220> <221> modified_base <222> (12)..(12) <223> 2'-fluorouracil <220> <221> modified_base <222> (13)..(13) <223> cm <220> <221> modified_base <222> (14)..(14) <223> 2'-fluorouracil <220> <221> modified_base <222> (15)..(15) <223> cm <220> <221> modified_base <222> (16)..(16) <223> 2'-fluoroguanine <220> <221> modified_base <222> (17)..(17) <223> um <220> <221> modified_base <222> (18)..(18) <223> 2'-fluorouracil <220> <221> modified_base <222> (19)..(19) <223> gm <220> <221> modified_base <222> (20)..(20) <223> 2'-fluoroadenine <220> <221> modified_base <222> (21)..(21) <223> gm <220> <221> modified_base <222> (22)..(22) <223> 2'-fluorouracil <220> <221> modified_base <222> (23)..(23) <223> cm <400> 1991 uuuucaagug cucucguuga guc 23 <210> 1992 <211> 23 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <220> <221> modified_base <222> (1)..(1) <223> 2'-fluoroadenine <220> <221> modified_base <222> (2)..(2) <223> um <220> <221> modified_base <222> (3)..(3) <223> 2'-fluorouracil <220> <221> modified_base <222> (4)..(4) <223> um <220> <221> modified_base <222> (5)..(5) <223> 2'-fluorouracil <220> <221> modified_base <222> (6)..(6) <223> cm <220> <221> modified_base <222> (7)..(7) <223> 2'-fluoroadenine <220> <221> modified_base <222> (8)..(8) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (9)..(9) <223> 2'-fluoroguanine <220> <221> modified_base <222> (10)..(10) <223> um <220> <221> modified_base <222> (11)..(11) <223> gm <220> <221> modified_base <222> (12)..(12) <223> 2'-fluorocytosine <220> <221> modified_base <222> (13)..(13) <223> um <220> <221> modified_base <222> (14)..(14) <223> 2'-fluorocytosine <220> <221> modified_base <222> (15)..(15) <223> um <220> <221> modified_base <222> (16)..(16) <223> 2'-fluorocytosine <220> <221> modified_base <222> (17)..(17) <223> gm <220> <221> modified_base <222> (18)..(18) <223> 2'-fluorouracil <220> <221> modified_base <222> (19)..(19) <223> um <220> <221> modified_base <222> (20)..(20) <223> 2'-fluoroguanine <220> <221> modified_base <222> (21)..(21) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (22)..(22) <223> 2'-fluoroguanine <220> <221> modified_base <222> (23)..(23) <223> um <400> 1992 auuuucaagu gcucucguug agu 23 <210> 1993 <211> 23 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <220> <221> modified_base <222> (1)..(1) <223> 2'-fluorouracil <220> <221> modified_base <222> (2)..(2) <223> cm <220> <221> modified_base <222> (3)..(3) <223> 2'-fluoroadenine <220> <221> modified_base <222> (4)..(4) <223> um <220> <221> modified_base <222> (5)..(5) <223> 2'-fluorouracil <220> <221> modified_base <222> (6)..(6) <223> um <220> <221> modified_base <222> (7)..(7) <223> 2'-fluorouracil <220> <221> modified_base <222> (8)..(8) <223> cm <220> <221> modified_base <222> (9)..(9) <223> 2'-fluoroadenine <220> <221> modified_base <222> (10)..(10) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (11)..(11) <223> gm <220> <221> modified_base <222> (12)..(12) <223> 2'-fluorouracil <220> <221> modified_base <222> (13)..(13) <223> gm <220> <221> modified_base <222> (14)..(14) <223> 2'-fluorocytosine <220> <221> modified_base <222> (15)..(15) <223> um <220> <221> modified_base <222> (16)..(16) <223> 2'-fluorocytosine <220> <221> modified_base <222> (17)..(17) <223> um <220> <221> modified_base <222> (18)..(18) <223> 2'-fluorocytosine <220> <221> modified_base <222> (19)..(19) <223> gm <220> <221> modified_base <222> (20)..(20) <223> 2'-fluorouracil <220> <221> modified_base <222> (21)..(21) <223> um <220> <221> modified_base <222> (22)..(22) <223> 2'-fluoroguanine <220> <221> modified_base <222> (23)..(23) <223> 2'-O-methyladenosine <400> 1993 ucauuuucaa gugcucucgu uga 23 <210> 1994 <211> 23 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <220> <221> modified_base <222> (1)..(1) <223> 2'-fluorouracil <220> <221> modified_base <222> (2)..(2) <223> um <220> <221> modified_base <222> (3)..(3) <223> 2'-fluorocytosine <220> <221> modified_base <222> (4)..(4) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (5)..(5) <223> 2'-fluorouracil <220> <221> modified_base <222> (6)..(6) <223> um <220> <221> modified_base <222> (7)..(7) <223> 2'-fluorouracil <220> <221> modified_base <222> (8)..(8) <223> um <220> <221> modified_base <222> (9)..(9) <223> 2'-fluorocytosine <220> <221> modified_base <222> (10)..(11) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (12)..(12) <223> 2'-fluoroguanine <220> <221> modified_base <222> (13)..(13) <223> um <220> <221> modified_base <222> (14)..(14) <223> 2'-fluoroguanine <220> <221> modified_base <222> (15)..(15) <223> cm <220> <221> modified_base <222> (16)..(16) <223> 2'-fluorouracil <220> <221> modified_base <222> (17)..(17) <223> cm <220> <221> modified_base <222> (18)..(18) <223> 2'-fluorouracil <220> <221> modified_base <222> (19)..(19) <223> cm <220> <221> modified_base <222> (20)..(20) <223> 2'-fluoroguanine <220> <221> modified_base <222> (21)..(21) <223> um <220> <221> modified_base <222> (22)..(22) <223> 2'-fluorouracil <220> <221> modified_base <222> (23)..(23) <223> gm <400> 1994 uucauuuuca agugcucucg uug 23 <210> 1995 <211> 23 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <220> <221> modified_base <222> (1)..(1) <223> 2'-fluorouracil <220> <221> modified_base <222> (2)..(2) <223> um <220> <221> modified_base <222> (3)..(3) <223> 2'-fluorouracil <220> <221> modified_base <222> (4)..(4) <223> cm <220> <221> modified_base <222> (5)..(5) <223> 2'-fluoroadenine <220> <221> modified_base <222> (6)..(6) <223> um <220> <221> modified_base <222> (7)..(7) <223> 2'-fluorouracil <220> <221> modified_base <222> (8)..(8) <223> um <220> <221> modified_base <222> (9)..(9) <223> 2'-fluorouracil <220> <221> modified_base <222> (10)..(10) <223> cm <220> <221> modified_base <222> (11)..(11) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (12)..(12) <223> 2'-fluoroadenine <220> <221> modified_base <222> (13)..(13) <223> gm <220> <221> modified_base <222> (14)..(14) <223> 2'-fluorouracil <220> <221> modified_base <222> (15)..(15) <223> gm <220> <221> modified_base <222> (16)..(16) <223> 2'-fluorocytosine <220> <221> modified_base <222> (17)..(17) <223> um <220> <221> modified_base <222> (18)..(18) <223> 2'-fluorocytosine <220> <221> modified_base <222> (19)..(19) <223> um <220> <221> modified_base <222> (20)..(20) <223> 2'-fluorocytosine <220> <221> modified_base <222> (21)..(21) <223> gm <220> <221> modified_base <222> (22)..(22) <223> 2'-fluorouracil <220> <221> modified_base <222> (23)..(23) <223> um <400> 1995 uuucauuuuc aagugcucuc guu 23 <210> 1996 <211> 23 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <220> <221> modified_base <222> (1)..(1) <223> 2'-fluoroadenine <220> <221> modified_base <222> (2)..(2) <223> um <220> <221> modified_base <222> (3)..(3) <223> 2'-fluorouracil <220> <221> modified_base <222> (4)..(4) <223> um <220> <221> modified_base <222> (5)..(5) <223> 2'-fluorocytosine <220> <221> modified_base <222> (6)..(6) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (7)..(7) <223> 2'-fluorouracil <220> <221> modified_base <222> (8)..(8) <223> um <220> <221> modified_base <222> (9)..(9) <223> 2'-fluorouracil <220> <221> modified_base <222> (10)..(10) <223> um <220> <221> modified_base <222> (11)..(11) <223> cm <220> <221> modified_base <222> (12)..(12) <223> 2'-fluoroadenine <220> <221> modified_base <222> (13)..(13) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (14)..(14) <223> 2'-fluoroguanine <220> <221> modified_base <222> (15)..(15) <223> um <220> <221> modified_base <222> (16)..(16) <223> 2'-fluoroguanine <220> <221> modified_base <222> (17)..(17) <223> cm <220> <221> modified_base <222> (18)..(18) <223> 2'-fluorouracil <220> <221> modified_base <222> (19)..(19) <223> cm <220> <221> modified_base <222> (20)..(20) <223> 2'-fluorouracil <220> <221> modified_base <222> (21)..(21) <223> cm <220> <221> modified_base <222> (22)..(22) <223> 2'-fluoroguanine <220> <221> modified_base <222> (23)..(23) <223> um <400> 1996 auuucauuuu caagugcucu cgu 23 <210> 1997 <211> 23 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <220> <221> modified_base <222> (1)..(1) <223> 2'-fluorocytosine <220> <221> modified_base <222> (2)..(2) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (3)..(3) <223> 2'-fluorouracil <220> <221> modified_base <222> (4)..(4) <223> um <220> <221> modified_base <222> (5)..(5) <223> 2'-fluorouracil <220> <221> modified_base <222> (6)..(6) <223> cm <220> <221> modified_base <222> (7)..(7) <223> 2'-fluoroadenine <220> <221> modified_base <222> (8)..(8) <223> um <220> <221> modified_base <222> (9)..(9) <223> 2'-fluorouracil <220> <221> modified_base <222> (10)..(11) <223> um <220> <221> modified_base <222> (12)..(12) <223> 2'-fluorocytosine <220> <221> modified_base <222> (13)..(13) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (14)..(14) <223> 2'-fluoroadenine <220> <221> modified_base <222> (15)..(15) <223> gm <220> <221> modified_base <222> (16)..(16) <223> 2'-fluorouracil <220> <221> modified_base <222> (17)..(17) <223> gm <220> <221> modified_base <222> (18)..(18) <223> 2'-fluorocytosine <220> <221> modified_base <222> (19)..(19) <223> um <220> <221> modified_base <222> (20)..(20) <223> 2'-fluorocytosine <220> <221> modified_base <222> (21)..(21) <223> um <220> <221> modified_base <222> (22)..(22) <223> 2'-fluorocytosine <220> <221> modified_base <222> (23)..(23) <223> gm <400> 1997 cauuucauuu ucaagugcuc ucg 23 <210> 1998 <211> 23 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <220> <221> modified_base <222> (1)..(1) <223> 2'-fluorouracil <220> <221> modified_base <222> (2)..(2) <223> gm <220> <221> modified_base <222> (3)..(3) <223> 2'-fluorocytosine <220> <221> modified_base <222> (4)..(4) <223> um <220> <221> modified_base <222> (5)..(5) <223> 2'-fluorouracil <220> <221> modified_base <222> (6)..(6) <223> um <220> <221> modified_base <222> (7)..(7) <223> 2'-fluoroguanine <220> <221> modified_base <222> (8)..(8) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (9)..(9) <223> 2'-fluorocytosine <220> <221> modified_base <222> (10)..(10) <223> cm <220> <221> modified_base <222> (11)..(11) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (12)..(12) <223> 2'-fluoroguanine <220> <221> modified_base <222> (13)..(13) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (14)..(14) <223> 2'-fluorouracil <220> <221> modified_base <222> (15)..(15) <223> cm <220> <221> modified_base <222> (16)..(16) <223> 2'-fluorouracil <220> <221> modified_base <222> (17)..(17) <223> cm <220> <221> modified_base <222> (18)..(18) <223> 2'-fluorouracil <220> <221> modified_base <222> (19)..(19) <223> um <220> <221> modified_base <222> (20)..(20) <223> 2'-fluoroadenine <220> <221> modified_base <222> (21)..(21) <223> gm <220> <221> modified_base <222> (22)..(22) <223> 2'-fluoroadenine <220> <221> modified_base <222> (23)..(23) <223> cm <400> 1998 ugcuuugacc agaucucuua gac 23 <210> 1999 <211> 23 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <220> <221> modified_base <222> (1)..(1) <223> 2'-fluoroguanine <220> <221> modified_base <222> (2)..(2) <223> um <220> <221> modified_base <222> (3)..(3) <223> 2'-fluoroadenine <220> <221> modified_base <222> (4)..(4) <223> um <220> <221> modified_base <222> (5)..(5) <223> 2'-fluorocytosine <220> <221> modified_base <222> (6)..(6) <223> cm <220> <221> modified_base <222> (7)..(7) <223> 2'-fluoroadenine <220> <221> modified_base <222> (8)..(8) <223> gm <220> <221> modified_base <222> (9)..(9) <223> 2'-fluorouracil <220> <221> modified_base <222> (10)..(10) <223> um <220> <221> modified_base <222> (11)..(11) <223> gm <220> <221> modified_base <222> (12)..(12) <223> 2'-fluorocytosine <220> <221> modified_base <222> (13)..(13) <223> um <220> <221> modified_base <222> (14)..(14) <223> 2'-fluorouracil <220> <221> modified_base <222> (15)..(15) <223> um <220> <221> modified_base <222> (16)..(16) <223> 2'-fluoroguanine <220> <221> modified_base <222> (17)..(17) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (18)..(18) <223> 2'-fluorocytosine <220> <221> modified_base <222> (19)..(19) <223> cm <220> <221> modified_base <222> (20)..(20) <223> 2'-fluoroadenine <220> <221> modified_base <222> (21)..(21) <223> gm <220> <221> modified_base <222> (22)..(22) <223> 2'-fluoroadenine <220> <221> modified_base <222> (23)..(23) <223> um <400> 1999 guauccaguu gcuuugacca gau 23 <210> 2000 <211> 23 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <220> <221> modified_base <222> (1)..(1) <223> 2'-fluoroadenine <220> <221> modified_base <222> (2)..(2) <223> gm <220> <221> modified_base <222> (3)..(3) <223> 2'-fluoroadenine <220> <221> modified_base <222> (4)..(4) <223> um <220> <221> modified_base <222> (5)..(5) <223> 2'-fluorocytosine <220> <221> modified_base <222> (6)..(6) <223> um <220> <221> modified_base <222> (7)..(7) <223> 2'-fluoroadenine <220> <221> modified_base <222> (8)..(8) <223> gm <220> <221> modified_base <222> (9)..(9) <223> 2'-fluorouracil <220> <221> modified_base <222> (10)..(10) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (11)..(11) <223> um <220> <221> modified_base <222> (12)..(12) <223> 2'-fluorocytosine <220> <221> modified_base <222> (13)..(13) <223> cm <220> <221> modified_base <222> (14)..(14) <223> 2'-fluoroadenine <220> <221> modified_base <222> (15)..(15) <223> gm <220> <221> modified_base <222> (16)..(16) <223> 2'-fluorouracil <220> <221> modified_base <222> (17)..(17) <223> um <220> <221> modified_base <222> (18)..(18) <223> 2'-fluoroguanine <220> <221> modified_base <222> (19)..(19) <223> cm <220> <221> modified_base <222> (20)..(20) <223> 2'-fluorouracil <220> <221> modified_base <222> (21)..(21) <223> um <220> <221> modified_base <222> (22)..(22) <223> 2'-fluorouracil <220> <221> modified_base <222> (23)..(23) <223> gm <400> 2000 agaucuagua uccaguugcu uug 23 <210> 2001 <211> 23 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <220> <221> modified_base <222> (1)..(1) <223> 2'-fluoroadenine <220> <221> modified_base <222> (2)..(2) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (3)..(3) <223> 2'-fluoroguanine <220> <221> modified_base <222> (4)..(4) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (5)..(5) <223> 2'-fluorouracil <220> <221> modified_base <222> (6)..(6) <223> cm <220> <221> modified_base <222> (7)..(7) <223> 2'-fluorouracil <220> <221> modified_base <222> (8)..(8) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (9)..(9) <223> 2'-fluoroguanine <220> <221> modified_base <222> (10)..(10) <223> um <220> <221> modified_base <222> (11)..(11) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (12)..(12) <223> 2'-fluorouracil <220> <221> modified_base <222> (13)..(13) <223> cm <220> <221> modified_base <222> (14)..(14) <223> 2'-fluorocytosine <220> <221> modified_base <222> (15)..(15) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (16)..(16) <223> 2'-fluoroguanine <220> <221> modified_base <222> (17)..(17) <223> um <220> <221> modified_base <222> (18)..(18) <223> 2'-fluorouracil <220> <221> modified_base <222> (19)..(19) <223> gm <220> <221> modified_base <222> (20)..(20) <223> 2'-fluorocytosine <220> <221> modified_base <222> (21)..(21) <223> um <220> <221> modified_base <222> (22)..(22) <223> 2'-fluorouracil <220> <221> modified_base <222> (23)..(23) <223> um <400> 2001 aagaucuagu auccaguugc uuu 23 <210> 2002 <211> 23 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <220> <221> modified_base <222> (1)..(1) <223> 2'-fluorouracil <220> <221> modified_base <222> (2)..(2) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (3)..(3) <223> 2'-fluoroadenine <220> <221> modified_base <222> (4)..(4) <223> gm <220> <221> modified_base <222> (5)..(5) <223> 2'-fluoroadenine <220> <221> modified_base <222> (6)..(6) <223> um <220> <221> modified_base <222> (7)..(7) <223> 2'-fluorocytosine <220> <221> modified_base <222> (8)..(8) <223> um <220> <221> modified_base <222> (9)..(9) <223> 2'-fluoroadenine <220> <221> modified_base <222> (10)..(10) <223> gm <220> <221> modified_base <222> (11)..(11) <223> um <220> <221> modified_base <222> (12)..(12) <223> 2'-fluoroadenine <220> <221> modified_base <222> (13)..(13) <223> um <220> <221> modified_base <222> (14)..(14) <223> 2'-fluorocytosine <220> <221> modified_base <222> (15)..(15) <223> cm <220> <221> modified_base <222> (16)..(16) <223> 2'-fluoroadenine <220> <221> modified_base <222> (17)..(17) <223> gm <220> <221> modified_base <222> (18)..(18) <223> 2'-fluorouracil <220> <221> modified_base <222> (19)..(19) <223> um <220> <221> modified_base <222> (20)..(20) <223> 2'-fluoroguanine <220> <221> modified_base <222> (21)..(21) <223> cm <220> <221> modified_base <222> (22)..(22) <223> 2'-fluorouracil <220> <221> modified_base <222> (23)..(23) <223> um <400> 2002 uaagaucuag uauccaguug cuu 23 <210> 2003 <211> 23 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <220> <221> modified_base <222> (1)..(1) <223> 2'-fluoroadenine <220> <221> modified_base <222> (2)..(2) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (3)..(3) <223> 2'-fluoroadenine <220> <221> modified_base <222> (4)..(4) <223> gm <220> <221> modified_base <222> (5)..(5) <223> 2'-fluoroadenine <220> <221> modified_base <222> (6)..(6) <223> gm <220> <221> modified_base <222> (7)..(7) <223> 2'-fluorocytosine <220> <221> modified_base <222> (8)..(8) <223> um <220> <221> modified_base <222> (9)..(9) <223> 2'-fluoroguanine <220> <221> modified_base <222> (10)..(10) <223> cm <220> <221> modified_base <222> (11)..(11) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (12)..(12) <223> 2'-fluoroguanine <220> <221> modified_base <222> (13)..(13) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (14)..(14) <223> 2'-fluorouracil <220> <221> modified_base <222> (15)..(15) <223> gm <220> <221> modified_base <222> (16)..(16) <223> 2'-fluorouracil <220> <221> modified_base <222> (17)..(17) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (18)..(18) <223> 2'-fluoroadenine <220> <221> modified_base <222> (19)..(19) <223> gm <220> <221> modified_base <222> (20)..(20) <223> 2'-fluoroadenine <220> <221> modified_base <222> (21)..(21) <223> um <220> <221> modified_base <222> (22)..(22) <223> 2'-fluorocytosine <220> <221> modified_base <222> (23)..(23) <223> um <400> 2003 aaagagcugc agauguaaga ucu 23 <210> 2004 <211> 23 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <220> <221> modified_base <222> (1)..(1) <223> 2'-fluoroguanine <220> <221> modified_base <222> (2)..(2) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (3)..(3) <223> 2'-fluoroadenine <220> <221> modified_base <222> (4)..(4) <223> gm <220> <221> modified_base <222> (5)..(5) <223> 2'-fluoroadenine <220> <221> modified_base <222> (6)..(6) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (7)..(7) <223> 2'-fluoroadenine <220> <221> modified_base <222> (8)..(8) <223> gm <220> <221> modified_base <222> (9)..(9) <223> 2'-fluoroadenine <220> <221> modified_base <222> (10)..(10) <223> gm <220> <221> modified_base <222> (11)..(11) <223> cm <220> <221> modified_base <222> (12)..(12) <223> 2'-fluorouracil <220> <221> modified_base <222> (13)..(13) <223> gm <220> <221> modified_base <222> (14)..(14) <223> 2'-fluorocytosine <220> <221> modified_base <222> (15)..(15) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (16)..(16) <223> 2'-fluoroguanine <220> <221> modified_base <222> (17)..(17) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (18)..(18) <223> 2'-fluorouracil <220> <221> modified_base <222> (19)..(19) <223> gm <220> <221> modified_base <222> (20)..(20) <223> 2'-fluorouracil <220> <221> modified_base <222> (21)..(21) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (22)..(22) <223> 2'-fluoroadenine <220> <221> modified_base <222> (23)..(23) <223> gm <400> 2004 gaagaaagag cugcagaugu aag 23 <210> 2005 <211> 23 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <220> <221> modified_base <222> (1)..(1) <223> 2'-fluoroadenine <220> <221> modified_base <222> (2)..(2) <223> gm <220> <221> modified_base <222> (3)..(3) <223> 2'-fluoroadenine <220> <221> modified_base <222> (4)..(4) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (5)..(5) <223> 2'-fluoroguanine <220> <221> modified_base <222> (6)..(6) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (7)..(7) <223> 2'-fluoroadenine <220> <221> modified_base <222> (8)..(8) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (9)..(9) <223> 2'-fluoroguanine <220> <221> modified_base <222> (10)..(10) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (11)..(11) <223> gm <220> <221> modified_base <222> (12)..(12) <223> 2'-fluorocytosine <220> <221> modified_base <222> (13)..(13) <223> um <220> <221> modified_base <222> (14)..(14) <223> 2'-fluoroguanine <220> <221> modified_base <222> (15)..(15) <223> cm <220> <221> modified_base <222> (16)..(16) <223> 2'-fluoroadenine <220> <221> modified_base <222> (17)..(17) <223> gm <220> <221> modified_base <222> (18)..(18) <223> 2'-fluoroadenine <220> <221> modified_base <222> (19)..(19) <223> um <220> <221> modified_base <222> (20)..(20) <223> 2'-fluoroguanine <220> <221> modified_base <222> (21)..(21) <223> um <220> <221> modified_base <222> (22)..(22) <223> 2'-fluoroadenine <220> <221> modified_base <222> (23)..(23) <223> 2'-O-methyladenosine <400> 2005 agaagaaaga gcugcagaug uaa 23 <210> 2006 <211> 23 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <220> <221> modified_base <222> (1)..(1) <223> 2'-fluoroadenine <220> <221> modified_base <222> (2)..(2) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (3)..(3) <223> 2'-fluoroguanine <220> <221> modified_base <222> (4)..(4) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (5)..(5) <223> 2'-fluoroadenine <220> <221> modified_base <222> (6)..(6) <223> gm <220> <221> modified_base <222> (7)..(7) <223> 2'-fluoroadenine <220> <221> modified_base <222> (8)..(8) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (9)..(9) <223> 2'-fluoroadenine <220> <221> modified_base <222> (10)..(10) <223> gm <220> <221> modified_base <222> (11)..(11) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (12)..(12) <223> 2'-fluoroguanine <220> <221> modified_base <222> (13)..(13) <223> cm <220> <221> modified_base <222> (14)..(14) <223> 2'-fluorouracil <220> <221> modified_base <222> (15)..(15) <223> gm <220> <221> modified_base <222> (16)..(16) <223> 2'-fluorocytosine <220> <221> modified_base <222> (17)..(17) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (18)..(18) <223> 2'-fluoroguanine <220> <221> modified_base <222> (19)..(19) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (20)..(20) <223> 2'-fluorouracil <220> <221> modified_base <222> (21)..(21) <223> gm <220> <221> modified_base <222> (22)..(22) <223> 2'-fluorouracil <220> <221> modified_base <222> (23)..(23) <223> 2'-O-methyladenosine <400> 2006 aagaagaaag agcugcagau gua 23 <210> 2007 <211> 23 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <220> <221> modified_base <222> (1)..(1) <223> 2'-fluoroadenine <220> <221> modified_base <222> (2)..(2) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (3)..(3) <223> 2'-fluoroadenine <220> <221> modified_base <222> (4)..(4) <223> gm <220> <221> modified_base <222> (5)..(5) <223> 2'-fluoroadenine <220> <221> modified_base <222> (6)..(6) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (7)..(7) <223> 2'-fluoroguanine <220> <221> modified_base <222> (8)..(8) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (9)..(9) <223> 2'-fluoroadenine <220> <221> modified_base <222> (10)..(10) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (11)..(11) <223> gm <220> <221> modified_base <222> (12)..(12) <223> 2'-fluoroadenine <220> <221> modified_base <222> (13)..(13) <223> gm <220> <221> modified_base <222> (14)..(14) <223> 2'-fluorocytosine <220> <221> modified_base <222> (15)..(15) <223> um <220> <221> modified_base <222> (16)..(16) <223> 2'-fluoroguanine <220> <221> modified_base <222> (17)..(17) <223> cm <220> <221> modified_base <222> (18)..(18) <223> 2'-fluoroadenine <220> <221> modified_base <222> (19)..(19) <223> gm <220> <221> modified_base <222> (20)..(20) <223> 2'-fluoroadenine <220> <221> modified_base <222> (21)..(21) <223> um <220> <221> modified_base <222> (22)..(22) <223> 2'-fluoroguanine <220> <221> modified_base <222> (23)..(23) <223> um <400> 2007 aaagaagaaa gagcugcaga ugu 23 <210> 2008 <211> 23 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <220> <221> modified_base <222> (1)..(1) <223> 2'-fluorocytosine <220> <221> modified_base <222> (2)..(2) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (3)..(3) <223> 2'-fluoroadenine <220> <221> modified_base <222> (4)..(4) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (5)..(5) <223> 2'-fluoroguanine <220> <221> modified_base <222> (6)..(6) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (7)..(7) <223> 2'-fluoroadenine <220> <221> modified_base <222> (8)..(8) <223> gm <220> <221> modified_base <222> (9)..(9) <223> 2'-fluoroadenine <220> <221> modified_base <222> (10)..(11) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (12)..(12) <223> 2'-fluoroguanine <220> <221> modified_base <222> (13)..(13) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (14)..(14) <223> 2'-fluoroguanine <220> <221> modified_base <222> (15)..(15) <223> cm <220> <221> modified_base <222> (16)..(16) <223> 2'-fluorouracil <220> <221> modified_base <222> (17)..(17) <223> gm <220> <221> modified_base <222> (18)..(18) <223> 2'-fluorocytosine <220> <221> modified_base <222> (19)..(19) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (20)..(20) <223> 2'-fluoroguanine <220> <221> modified_base <222> (21)..(21) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (22)..(22) <223> 2'-fluorouracil <220> <221> modified_base <222> (23)..(23) <223> gm <400> 2008 caaagaagaa agagcugcag aug 23 <210> 2009 <211> 23 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <220> <221> modified_base <222> (1)..(1) <223> 2'-fluorouracil <220> <221> modified_base <222> (2)..(2) <223> cm <220> <221> modified_base <222> (3)..(3) <223> 2'-fluoroadenine <220> <221> modified_base <222> (4)..(4) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (5)..(5) <223> 2'-fluoroadenine <220> <221> modified_base <222> (6)..(6) <223> gm <220> <221> modified_base <222> (7)..(7) <223> 2'-fluoroadenine <220> <221> modified_base <222> (8)..(8) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (9)..(9) <223> 2'-fluoroguanine <220> <221> modified_base <222> (10)..(11) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (12)..(12) <223> 2'-fluoroadenine <220> <221> modified_base <222> (13)..(13) <223> gm <220> <221> modified_base <222> (14)..(14) <223> 2'-fluoroadenine <220> <221> modified_base <222> (15)..(15) <223> gm <220> <221> modified_base <222> (16)..(16) <223> 2'-fluorocytosine <220> <221> modified_base <222> (17)..(17) <223> um <220> <221> modified_base <222> (18)..(18) <223> 2'-fluoroguanine <220> <221> modified_base <222> (19)..(19) <223> cm <220> <221> modified_base <222> (20)..(20) <223> 2'-fluoroadenine <220> <221> modified_base <222> (21)..(21) <223> gm <220> <221> modified_base <222> (22)..(22) <223> 2'-fluoroadenine <220> <221> modified_base <222> (23)..(23) <223> um <400> 2009 ucaaagaaga aagagcugca gau 23 <210> 2010 <211> 23 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <220> <221> modified_base <222> (1)..(1) <223> 2'-fluorouracil <220> <221> modified_base <222> (2)..(2) <223> um <220> <221> modified_base <222> (3)..(3) <223> 2'-fluorocytosine <220> <221> modified_base <222> (4)..(4) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (5)..(5) <223> 2'-fluoroadenine <220> <221> modified_base <222> (6)..(6) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (7)..(7) <223> 2'-fluoroguanine <220> <221> modified_base <222> (8)..(8) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (9)..(9) <223> 2'-fluoroadenine <220> <221> modified_base <222> (10)..(10) <223> gm <220> <221> modified_base <222> (11)..(11) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (12)..(12) <223> 2'-fluoroadenine <220> <221> modified_base <222> (13)..(13) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (14)..(14) <223> 2'-fluoroguanine <220> <221> modified_base <222> (15)..(15) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (16)..(16) <223> 2'-fluoroguanine <220> <221> modified_base <222> (17)..(17) <223> cm <220> <221> modified_base <222> (18)..(18) <223> 2'-fluorouracil <220> <221> modified_base <222> (19)..(19) <223> gm <220> <221> modified_base <222> (20)..(20) <223> 2'-fluorocytosine <220> <221> modified_base <222> (21)..(21) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (22)..(22) <223> 2'-fluoroguanine <220> <221> modified_base <222> (23)..(23) <223> 2'-O-methyladenosine <400> 2010 uucaaagaag aaagagcugc aga 23 <210> 2011 <211> 23 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <220> <221> modified_base <222> (1)..(1) <223> 2'-fluoroadenine <220> <221> modified_base <222> (2)..(2) <223> um <220> <221> modified_base <222> (3)..(3) <223> 2'-fluorouracil <220> <221> modified_base <222> (4)..(4) <223> cm <220> <221> modified_base <222> (5)..(5) <223> 2'-fluoroadenine <220> <221> modified_base <222> (6)..(6) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (7)..(7) <223> 2'-fluoroadenine <220> <221> modified_base <222> (8)..(8) <223> gm <220> <221> modified_base <222> (9)..(9) <223> 2'-fluoroadenine <220> <221> modified_base <222> (10)..(10) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (11)..(11) <223> gm <220> <221> modified_base <222> (12)..(12) <223> 2'-fluoroadenine <220> <221> modified_base <222> (13)..(13) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (14)..(14) <223> 2'-fluoroadenine <220> <221> modified_base <222> (15)..(15) <223> gm <220> <221> modified_base <222> (16)..(16) <223> 2'-fluoroadenine <220> <221> modified_base <222> (17)..(17) <223> gm <220> <221> modified_base <222> (18)..(18) <223> 2'-fluorocytosine <220> <221> modified_base <222> (19)..(19) <223> um <220> <221> modified_base <222> (20)..(20) <223> 2'-fluoroguanine <220> <221> modified_base <222> (21)..(21) <223> cm <220> <221> modified_base <222> (22)..(22) <223> 2'-fluoroadenine <220> <221> modified_base <222> (23)..(23) <223> gm <400> 2011 auucaaagaa gaaagagcug cag 23 <210> 2012 <211> 23 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <220> <221> modified_base <222> (1)..(1) <223> 2'-fluoroadenine <220> <221> modified_base <222> (2)..(2) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (3)..(3) <223> 2'-fluorouracil <220> <221> modified_base <222> (4)..(4) <223> um <220> <221> modified_base <222> (5)..(5) <223> 2'-fluorocytosine <220> <221> modified_base <222> (6)..(6) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (7)..(7) <223> 2'-fluoroadenine <220> <221> modified_base <222> (8)..(8) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (9)..(9) <223> 2'-fluoroguanine <220> <221> modified_base <222> (10)..(11) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (12)..(12) <223> 2'-fluoroguanine <220> <221> modified_base <222> (13)..(13) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (14)..(14) <223> 2'-fluoroadenine <220> <221> modified_base <222> (15)..(15) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (16)..(16) <223> 2'-fluoroguanine <220> <221> modified_base <222> (17)..(17) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (18)..(18) <223> 2'-fluoroguanine <220> <221> modified_base <222> (19)..(19) <223> cm <220> <221> modified_base <222> (20)..(20) <223> 2'-fluorouracil <220> <221> modified_base <222> (21)..(21) <223> gm <220> <221> modified_base <222> (22)..(22) <223> 2'-fluorocytosine <220> <221> modified_base <222> (23)..(23) <223> 2'-O-methyladenosine <400> 2012 aauucaaaga agaaagagcu gca 23 <210> 2013 <211> 23 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <220> <221> modified_base <222> (1)..(1) <223> 2'-fluoroadenine <220> <221> modified_base <222> (2)..(2) <223> cm <220> <221> modified_base <222> (3)..(3) <223> 2'-fluoroadenine <220> <221> modified_base <222> (4)..(4) <223> um <220> <221> modified_base <222> (5)..(5) <223> 2'-fluoroadenine <220> <221> modified_base <222> (6)..(6) <223> cm <220> <221> modified_base <222> (7)..(7) <223> 2'-fluoroadenine <220> <221> modified_base <222> (8)..(8) <223> gm <220> <221> modified_base <222> (9)..(9) <223> 2'-fluoroadenine <220> <221> modified_base <222> (10)..(10) <223> um <220> <221> modified_base <222> (11)..(11) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (12)..(12) <223> 2'-fluoroguanine <220> <221> modified_base <222> (13)..(13) <223> gm <220> <221> modified_base <222> (14)..(14) <223> 2'-fluoroadenine <220> <221> modified_base <222> (15)..(15) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (16)..(16) <223> 2'-fluoroadenine <220> <221> modified_base <222> (17)..(17) <223> um <220> <221> modified_base <222> (18)..(18) <223> 2'-fluorouracil <220> <221> modified_base <222> (19)..(19) <223> cm <220> <221> modified_base <222> (20)..(20) <223> 2'-fluoroadenine <220> <221> modified_base <222> (21)..(21) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (22)..(22) <223> 2'-fluoroadenine <220> <221> modified_base <222> (23)..(23) <223> gm <400> 2013 acauacagau aggaaauuca aag 23 <210> 2014 <211> 23 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <220> <221> modified_base <222> (1)..(1) <223> 2'-fluorouracil <220> <221> modified_base <222> (2)..(2) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (3)..(3) <223> 2'-fluoroguanine <220> <221> modified_base <222> (4)..(4) <223> gm <220> <221> modified_base <222> (5)..(5) <223> 2'-fluorocytosine <220> <221> modified_base <222> (6)..(6) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (7)..(7) <223> 2'-fluoroguanine <220> <221> modified_base <222> (8)..(8) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (9)..(9) <223> 2'-fluorocytosine <220> <221> modified_base <222> (10)..(10) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (11)..(11) <223> um <220> <221> modified_base <222> (12)..(12) <223> 2'-fluoroadenine <220> <221> modified_base <222> (13)..(13) <223> cm <220> <221> modified_base <222> (14)..(14) <223> 2'-fluoroadenine <220> <221> modified_base <222> (15)..(15) <223> gm <220> <221> modified_base <222> (16)..(16) <223> 2'-fluoroadenine <220> <221> modified_base <222> (17)..(17) <223> um <220> <221> modified_base <222> (18)..(18) <223> 2'-fluoroadenine <220> <221> modified_base <222> (19)..(19) <223> gm <220> <221> modified_base <222> (20)..(20) <223> 2'-fluoroguanine <220> <221> modified_base <222> (21)..(21) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (22)..(22) <223> 2'-fluoroadenine <220> <221> modified_base <222> (23)..(23) <223> 2'-O-methyladenosine <400> 2014 uaggcagaca uacagauagg aaa 23 <210> 2015 <211> 23 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <220> <221> modified_base <222> (1)..(1) <223> 2'-fluorouracil <220> <221> modified_base <222> (2)..(2) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (3)..(3) <223> 2'-fluoroadenine <220> <221> modified_base <222> (4)..(4) <223> um <220> <221> modified_base <222> (5)..(5) <223> 2'-fluorouracil <220> <221> modified_base <222> (6)..(6) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (7)..(7) <223> 2'-fluoroguanine <220> <221> modified_base <222> (8)..(8) <223> gm <220> <221> modified_base <222> (9)..(9) <223> 2'-fluorocytosine <220> <221> modified_base <222> (10)..(10) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (11)..(11) <223> gm <220> <221> modified_base <222> (12)..(12) <223> 2'-fluoroadenine <220> <221> modified_base <222> (13)..(13) <223> cm <220> <221> modified_base <222> (14)..(14) <223> 2'-fluoroadenine <220> <221> modified_base <222> (15)..(15) <223> um <220> <221> modified_base <222> (16)..(16) <223> 2'-fluoroadenine <220> <221> modified_base <222> (17)..(17) <223> cm <220> <221> modified_base <222> (18)..(18) <223> 2'-fluoroadenine <220> <221> modified_base <222> (19)..(19) <223> gm <220> <221> modified_base <222> (20)..(20) <223> 2'-fluoroadenine <220> <221> modified_base <222> (21)..(21) <223> um <220> <221> modified_base <222> (22)..(22) <223> 2'-fluoroadenine <220> <221> modified_base <222> (23)..(23) <223> gm <400> 2015 uaauuaggca gacauacaga uag 23 <210> 2016 <211> 23 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <220> <221> modified_base <222> (1)..(1) <223> 2'-fluorouracil <220> <221> modified_base <222> (2)..(2) <223> um <220> <221> modified_base <222> (3)..(3) <223> 2'-fluoroadenine <220> <221> modified_base <222> (4)..(4) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (5)..(5) <223> 2'-fluorouracil <220> <221> modified_base <222> (6)..(6) <223> um <220> <221> modified_base <222> (7)..(7) <223> 2'-fluoroadenine <220> <221> modified_base <222> (8)..(8) <223> gm <220> <221> modified_base <222> (9)..(9) <223> 2'-fluoroguanine <220> <221> modified_base <222> (10)..(10) <223> cm <220> <221> modified_base <222> (11)..(11) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (12)..(12) <223> 2'-fluoroguanine <220> <221> modified_base <222> (13)..(13) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (14)..(14) <223> 2'-fluorocytosine <220> <221> modified_base <222> (15)..(15) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (16)..(16) <223> 2'-fluorouracil <220> <221> modified_base <222> (17)..(17) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (18)..(18) <223> 2'-fluorocytosine <220> <221> modified_base <222> (19)..(19) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (20)..(20) <223> 2'-fluoroguanine <220> <221> modified_base <222> (21)..(21) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (22)..(22) <223> 2'-fluorouracil <220> <221> modified_base <222> (23)..(23) <223> 2'-O-methyladenosine <400> 2016 uuaauuaggc agacauacag aua 23 <210> 2017 <211> 23 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <220> <221> modified_base <222> (1)..(1) <223> 2'-fluorouracil <220> <221> modified_base <222> (2)..(2) <223> um <220> <221> modified_base <222> (3)..(3) <223> 2'-fluorouracil <220> <221> modified_base <222> (4)..(4) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (5)..(5) <223> 2'-fluoroadenine <220> <221> modified_base <222> (6)..(6) <223> um <220> <221> modified_base <222> (7)..(7) <223> 2'-fluorouracil <220> <221> modified_base <222> (8)..(8) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (9)..(9) <223> 2'-fluoroguanine <220> <221> modified_base <222> (10)..(10) <223> gm <220> <221> modified_base <222> (11)..(11) <223> cm <220> <221> modified_base <222> (12)..(12) <223> 2'-fluoroadenine <220> <221> modified_base <222> (13)..(13) <223> gm <220> <221> modified_base <222> (14)..(14) <223> 2'-fluoroadenine <220> <221> modified_base <222> (15)..(15) <223> cm <220> <221> modified_base <222> (16)..(16) <223> 2'-fluoroadenine <220> <221> modified_base <222> (17)..(17) <223> um <220> <221> modified_base <222> (18)..(18) <223> 2'-fluoroadenine <220> <221> modified_base <222> (19)..(19) <223> cm <220> <221> modified_base <222> (20)..(20) <223> 2'-fluoroadenine <220> <221> modified_base <222> (21)..(21) <223> gm <220> <221> modified_base <222> (22)..(22) <223> 2'-fluoroadenine <220> <221> modified_base <222> (23)..(23) <223> um <400> 2017 uuuaauuagg cagacauaca gau 23 <210> 2018 <211> 23 <212> RNA <213> Artificial Sequence <220> <223> siRNA antisense strand against APCS <220> <221> modified_base <222> (1)..(1) <223> 2'-fluorouracil <220> <221> modified_base <222> (2)..(2) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (3)..(3) <223> 2'-fluorouracil <220> <221> modified_base <222> (4)..(4) <223> um <220> <221> modified_base <222> (5)..(5) <223> 2'-fluorouracil <220> <221> modified_base <222> (6)..(6) <223> um <220> <221> modified_base <222> (7)..(7) <223> 2'-fluorouracil <220> <221> modified_base <222> (8)..(8) <223> um <220> <221> modified_base <222> (9)..(9) <223> 2'-fluorouracil <220> <221> modified_base <222> (10)..(11) <223> 2'-O-methyladenosine <220> <221> modified_base <222> (12)..(12) <223> 2'-fluorouracil <220> <221> modified_base <222> (13)..(13) <223> um <220> <221> modified_base <222> (14)..(14) <223> 2'-fluoroadenine <220> <221> modified_base <222> (15)..(15) <223> gm <220> <221> modified_base <222> (16)..(16) <223> 2'-fluoroguanine <220> <221> modified_base <222> (17)..(17) <223> cm <220> <221> modified_base <222> (18)..(18) <223> 2'-fluoroadenine <220> <221> modified_base <222> (19)..(19) <223> gm <220> <221> modified_base <222> (20)..(20) <223> 2'-fluoroadenine <220> <221> modified_base <222> (21)..(21) <223> cm <220> <221> modified_base <222> (22)..(22) <223> 2'-fluoroadenine <220> <221> modified_base <222> (23)..(23) <223> um <400> 2018 uauuuuuuua auuaggcaga cau 23

Claims

센스쇄 핵산 및 안티센스쇄 핵산으로 이루어지고, 적어도 11개의 염기쌍의 이중쇄 영역을 포함하는 이중쇄 핵산으로서, 상기 안티센스쇄 핵산 중의, 적어도 17개의 뉴클레오티드이며 많아도 30개의 뉴클레오티드의 쇄길이의 올리고뉴클레오티드쇄에 있어서, 서열 번호 1288∼1930 중 어느 것으로 표시되는 염기 서열을 포함하는 표적 APCS mRNA 서열과 상보적인, APCS 유전자의 발현을 억제시키는 이중쇄 핵산.
제1항에 있어서, 상기 이중쇄 영역이 11∼27개의 염기쌍이며, 상기 안티센스쇄 핵산의 5' 말단으로부터 2번째의 뉴클레오티드가, 상기 표적 APCS mRNA 서열의 3' 말단으로부터 2번째의 데옥시리보뉴클레오티드와 상보하는 이중쇄 핵산.
제1항 또는 제2항에 있어서, 상기 센스쇄 핵산의 3' 말단 및 상기 안티센스쇄 핵산의 5' 말단, 및/또는, 상기 센스쇄 핵산의 5' 말단 및 상기 안티센스쇄 핵산의 3' 말단이, 평활 말단을 형성하는 이중쇄 핵산.
제1항 내지 제3항 중 어느 한 항에 있어서, 상기 센스쇄 핵산은 21개의 뉴클레오티드의 쇄길이를 가지며, 또한 상기 안티센스쇄 핵산은 21개의 뉴클레오티드의 쇄길이를 갖는 이중쇄 핵산.
제4항에 있어서, 19개의 염기쌍의 이중쇄 영역을 포함하고, 상기 이중쇄 영역 내의 40∼65%의 뉴클레오티드가 2'-O-메틸 수식 뉴클레오티드인 이중쇄 핵산.
제1항 내지 제5항 중 어느 한 항에 있어서, 상기 안티센스쇄 핵산은, 서열 번호 645∼1287 및 1975∼2018 중 어느 것으로 표시되는 염기 서열을 포함하는 이중쇄 핵산.
제1항 내지 제6항 중 어느 한 항에 있어서, 상기 센스쇄 핵산은, 서열 번호 2∼644 및 1931∼1974 중 어느 것으로 표시되는 염기 서열을 포함하는 이중쇄 핵산.
제1항 내지 제7항 중 어느 한 항에 있어서, 상기 센스쇄 핵산은, 서열 번호 2∼644 및 1931∼1974 중 어느 것으로 표시되는 염기 서열을 포함하고, 그것에 대응하여, 상기 안티센스쇄 핵산은, 서열 번호 645∼1287 및 1975∼2018 중 어느 것으로 표시되는 염기 서열을 포함하는 이중쇄 핵산.
제1항 내지 제8항 중 어느 한 항에 있어서, 리간드를 포함하는 이중쇄 핵산.
제1항 내지 제9항 중 어느 한 항에 기재된 이중쇄 핵산의, 안티센스쇄 핵산만으로 이루어진 단일쇄 핵산.
제1항 내지 제10항 중 어느 한 항에 기재된 핵산을 포함하는 의약 조성물.
APCS를 포함한 아밀로이드 섬유에 의해 매개되는 장해를 치료하는 방법으로서, 치료상 유효량의, 제1항 내지 제10항 중 어느 한 항에 기재된 핵산 또는 제11항에 기재된 의약 조성물을, 그와 같은 치료를 필요로 하는 인간에게 투여하는 단계를 포함하는 방법.
제12항에 있어서, 상기 장해가 아밀로이드 관련 질환인 방법.