KR20190122627A - Irreversible electroporation device - Google Patents

Irreversible electroporation device Download PDF

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KR20190122627A
KR20190122627A KR1020190132008A KR20190132008A KR20190122627A KR 20190122627 A KR20190122627 A KR 20190122627A KR 1020190132008 A KR1020190132008 A KR 1020190132008A KR 20190132008 A KR20190132008 A KR 20190132008A KR 20190122627 A KR20190122627 A KR 20190122627A
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ire
channel
operation unit
working channel
probes
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최혁순
박상현
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고려대학교 산학협력단
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/00064—Constructional details of the endoscope body
    • A61B1/00071—Insertion part of the endoscope body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
    • A61M25/02—Holding devices, e.g. on the body
    • A61M25/04—Holding devices, e.g. on the body in the body, e.g. expansible
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/10—Balloon catheters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00571—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for achieving a particular surgical effect
    • A61B2018/00595—Cauterization
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00982—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body combined with or comprising means for visual or photographic inspections inside the body, e.g. endoscopes

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  • Life Sciences & Earth Sciences (AREA)
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  • Endoscopes (AREA)

Abstract

The present invention relates to an irreversible electroporation device which comprises: an endoscope tube (110) including a working channel (111) formed therein; two IRE probes (130a, 130b) made of a flexible material and received in the working channel; and an operation unit coupled to a rear end of the working channel. A fixing means is provided in one IPR probe (130a) of the two IRE probes (130a, 130b) formed in the working channel, and is configured to be a balloon (131) provided outside the IRE probe (130a). The balloon is connected to an air channel which supplies air and is expanded to be adhering to an inner surface of the working channel. The IRE probes are steered by a steering wire, and a distance between tips of each of the IRE probes is adjustable, thereby changing a scope of stimulation. The endoscope tube includes: an optical channel for an endoscopic camera; a fluid channel for injecting a medicament; and a lighting channel for illumination. The operation unit includes: an operation unit for supplying electricity for a surgery; an operation unit for performing a steering operation; and an operation unit for operating the air channel which supplies air to the balloon. High current flows in each of the two IRE probes so that a magnetic field is formed between the both tips of the IRE probes, thereby cauterizing malignant neoplasms in a single cell unit.

Description

비가역적 전기천공법 장치{IRREVERSIBLE ELECTROPORATION DEVICE}Irreversible electroporation apparatus {IRREVERSIBLE ELECTROPORATION DEVICE}

본 발명은 비가역적 전기천공법 장치에 관한 것으로서, 더욱 상세하게는 비가역적 전기천공법을 효과적으로 수행하기 위한 장치에 관한 것이다.The present invention relates to an irreversible electroporation apparatus, and more particularly, to an apparatus for effectively performing irreversible electroporation.

비가역적 전기천공법 (IRE: irreversible electroporation) 장치는 양 끝단에 고전류를 흐르게 하여 양 끝단 사이에 강한 전기장을 생성하여 암과 같은 악성신생물을 세포단위로 소작하여 제거하는 장치로서, 일반적으로 내시경과 함께 수술에 사용된다. 하지만, 종래에는 수술시 IRE 장치와 내시경 장치가 독립되어서 사용되기 때문에, 수술 공간 확보 및 조작에 있어서 불편함이 존재하여 개선이 요구된다.An irreversible electroporation (IRE) device is a device that removes malignant neoplasms such as cancer by cauterizing cells by generating a strong electric field between both ends by flowing a high current at both ends. Used for surgery together. However, in the prior art, since the IRE device and the endoscope device are used independently during surgery, there is an inconvenience in securing and manipulating the surgical space, and improvement is required.

미국 공개특허 US 2009/0062788 A1 "ELECTRICAL ABLATION SURGICAL INSTRUMENT" (2009.05.05.)US Patent Publication US 2009/0062788 A1 "ELECTRICAL ABLATION SURGICAL INSTRUMENT" (2009.05.05.)

본 발명의 목적은 수술 공간 확보 및 조작이 용이한 비가역적 전기천공법 장치를 제공하는 것이다.It is an object of the present invention to provide an irreversible electroporation apparatus that is easy to secure and manipulate a surgical space.

위와 같은 목적을 달성하기 위하여, 본 발명의 실시예에 따른 비가역적 전기천공법 장치는 내부에 형성된 워킹 채널(111)을 구비하는 내시경관(110); 워킹 채널의 내부에 수용되며, 유연한 재질로 이루어지는 두 IRE 프로브(130a, 130b); 워킹 채널의 후단에 결합되는 조작부; 및 워킹 채널 내에서 두 IRE 프로브 중 하나의 IRE 프로브(130a)에는 고정 수단이 마련되고, 고정 수단은 IRE 프로브(130a)의 외부에 마련되는 벌룬(131)이며, 벌룬은 에어를 공급하는 에어 채널과 연결되며, 벌룬은 팽창되어서 워킹 채널의 내면과 밀착되고, IRE 프로브는 스터어링 와이어에 의해 조향되고, 각 선단의 서로 이웃하는 거리가 조절되어서 자극 범위의 변경이 가능하며, 내시경관은 내시경 카메라를 위한 광학 채널, 약물 주입을 위한 유체 채널 및 조명을 위한 조명채널을 더 구비하고, 조작부는 수술을 위한 전기를 공급하는 조작부, 조향을 위한 조작부 및 벌룬으로 에어를 공급하는 에어채널을 조작하는 조작부를 구비하고, 두 IRE 프로브는 각각에 고전류를 흐르게 하여 양 선단 사이에 자기장이 형성되어 악성신생물을 세포단위로 소작할 수 있다.In order to achieve the above object, the irreversible electroporation apparatus according to an embodiment of the present invention comprises an endoscope tube 110 having a working channel 111 formed therein; Two IRE probes 130a and 130b accommodated inside the working channel and made of a flexible material; An operation unit coupled to the rear end of the working channel; And a fixing means is provided in one IRE probe 130a of the two IRE probes in the working channel, and the fixing means is a balloon 131 provided outside the IRE probe 130a, and the balloon is an air channel for supplying air. The balloon is inflated to be in close contact with the inner surface of the working channel, the IRE probe is steered by the steering wire, and the adjacent distances of each tip are adjusted to change the magnetic pole range, and the endoscope is an endoscope camera. Further comprising an optical channel for the injection, fluid channel for drug injection and illumination channel for illumination, the operation unit for operating the operation unit for supplying electricity for surgery, the operation unit for steering and the operation unit for operating the air channel for supplying air to the balloon The two IRE probes have a high current flowing through each of them, and a magnetic field is formed between the two tips, so that malignant neoplasms can be cauterized in cell units.

본 발명에 의하면 앞서서 기재된 본 발명의 목적을 모두 달성할 수 있다. 구체적으로는, IRE 프로브가 내시경관의 워킹 채널에 고정되어서 내시경과 IRE 프로브가 결합된 상태에서 함께 조작될 수 있으므로 수술 공간 확보 및 조작이 용이해질 수 있다.According to the present invention, all the objects of the present invention described above can be achieved. Specifically, since the IRE probe is fixed to the working channel of the endoscope, the endoscope and the IRE probe may be operated together in a combined state, thereby securing and operating a surgical space.

도 1은 본 발명의 일 실시예에 따른 IRE 장치의 전체 구성을 개략적으로 도시한 도면이다.
도 2는 도 1에 도시된 내시경 관의 끝단을 도시한 사시도이다.
도 3은 도 1에 도시된 내시경 관 일부의 단면도로서, IRE 프로브가 내시경 관의 워킹 채널에 고정된 상태를 도시한 것이다.1 is a view schematically showing the overall configuration of an IRE device according to an embodiment of the present invention.
Figure 2 is a perspective view of the end of the endoscope tube shown in FIG.
FIG. 3 is a cross-sectional view of a portion of the endoscope tube shown in FIG. 1 showing the IRE probe secured to the working channel of the endoscope tube. FIG.

이하, 도면을 참조하여 본 발명의 바람직한 실시예의 구성 및 작용을 상세하게 설명한다.Hereinafter, with reference to the drawings will be described in detail the configuration and operation of the preferred embodiment of the present invention.

도 1에는 본 발명의 일 실시예에 따른 IRE 장치의 개략적인 구성이 도시되어 있다. 도 1을 참조하면, 본 발명의 일 실시예에 따른 IRE 장치(100)는 내시경관(110)과, 내시경관(110)의 후단에 고정되는 몸체부(120)와, 내시경관(110)의 내에 수용되는 두 IRE 프로브(130a, 130b)와, 두 IRE 프로브(130a, 130b)의 선단에 위치하고 몸체부(120)의 밖에 위치하는 IRE 조작부(140)를 포함한다. 내시경관(110)과 몸체부(120)은 워킹 채널을 구비하는 통상적인 구조의 내시경 장치로 구성될 수 있다.1 shows a schematic configuration of an IRE device according to an embodiment of the present invention. Referring to FIG. 1, an IRE device 100 according to an embodiment of the present invention includes an endoscope tube 110, a body 120 fixed to a rear end of the endoscope tube 110, and an endoscope tube 110. Two IRE probes 130a and 130b accommodated therein, and an IRE manipulation unit 140 positioned at the tip of the two IRE probes 130a and 130b and positioned outside the body 120. Endoscope tube 110 and the body portion 120 may be configured as an endoscope device having a conventional structure having a working channel.

도 1과 함께 내시경관(110)의 선단부가 사시도로서 도시된 도 2를 참조하면, 내시경관(110)은 길게 연장되는 유연한 관으로서, 내부에는 그 길이방향을 따라서 연장되는 워킹 채널(111)이 마련된다. 워킹 채널(111)에 두 IRE 프로브(130a, 130b)가 수용된다. 내시경관(111)에는 추가적으로 내시경 카메라(112)를 위한 광학 채널, 약물 주입 등을 위한 유체 채널(113)과, 조명을 위한 조명 채널(114)이 더 구비될 수 있다. 워킹 채널(111)을 구비하는 내시경관(110)은 내시경 장치에서 통상적으로 사용되는 구조로 구성될 수 있다.Referring to FIG. 2, in which the distal end of the endoscope tube 110 is shown as a perspective view in conjunction with FIG. 1, the endoscope tube 110 is a flexible tube that is elongated, and a working channel 111 extending along the longitudinal direction thereof. Prepared. Two IRE probes 130a and 130b are accommodated in the working channel 111. The endoscope tube 111 may further include an optical channel for the endoscope camera 112, a fluid channel 113 for drug injection, and an illumination channel 114 for illumination. Endoscope tube 110 having a working channel 111 may be configured in a structure commonly used in the endoscope device.

몸체부(120)는 내시경관(110)의 후단에 결합된다. 몸체부(120)에는 내시경관(110)의 워킹 채널(111)과 연결되는 입구부(121)가 마련된다. 추가적으로 몸체부(120)에는 외부 장치와의 연결을 위한 연결부 및 내시경 카메라(112) 및 조명의 작동 등을 위한 조작부가 더 구비되는데, 이러한 구성은 종래의 내시경 장치에서 통상적으로 사용되는 구성으로 이루어질 수 있으므로 이에 대한 상세한 설명은 생략한다.Body 120 is coupled to the rear end of the endoscope tube 110. The body part 120 is provided with an inlet part 121 connected with the working channel 111 of the endoscope tube 110. In addition, the body portion 120 is further provided with a connection portion for connecting to the external device and the operation unit for the operation of the endoscope camera 112 and the lighting, such a configuration can be made of a configuration commonly used in conventional endoscope devices. Therefore, detailed description thereof will be omitted.

두 IRE 프로브(130a, 130b) 각각은 길게 연장되는 선재의 형태로서 조향이 가능하도록 유연한 재질로 이루어진다. 두 IRE 프로브(130a, 130b)는 종래의 IRE 프로브의 구성으로 이루어지므로 이에 대한 상세한 설명은 생략한다. 두 IRE 프로브(130a, 130b) 각각은 워킹 채널(111) 내에 수용되어서 워킹 채널(111)을 따라서 길게 연장되며, 선단부는 내시경관(110)의 선단으로부터 돌출되어서 더 연장된다. 두 IRE 프로브(130a, 130b) 각각에 고전류를 흐르게 하여 양 선단 사이에 강한 전기장이 강한 자기장이 형성되어 암과 같은 악성신생물이 세포단위로 소작되어 제거된다. 두 IRE 프로브(130a, 130b) 각각은 조향 가능한 구조를 갖는데, 이는 스티어링 와이어 등을 이용하는 통상적인 조향 방식을 이용하여 실현될 수 있다. 두 IRE 프로브(130a, 130b)의 조향을 통해 각 선단 사이의 거리(d)가 조절되어서 자극 범위의 변경이 가능하게 된다. 두 IRE 프로브(130a, 130b) 각각은 몸체부(120)에 형성된 입구부(121)를 통해 삽입되어 내시경관(110)의 워킹 채널(111)을 통과하게 되는데, 두 IRE 프로브(130a, 130b) 각각은 수술시 내시경관(110)과의 효과적인 상호작용을 위해 내시경관(110)의 워킹 채널(111) 내에서 움직이지 않도록 고정될 필요가 있다. 이를 위하여, 두 IRE 프로브(130a, 130b) 각각에는 고정 수단이 마련되는데, 도 3에는 두 IRE 프로브(130a, 130b) 중 하나의 IRE 프로브(130a)가 워킹 채널(111) 내에서 고정 수단에 의해 고정된 상태가 대표적으로 도시되어 있다. 도 3을 참조하면, IRE 프로브(130a)를 워킹 채널(111) 내에서 고정시키는 고정 수단은 IRE 프로브(130a)에 마련되는 벌룬(balloon)(131)으로서, IRE 프로브(130a)가 워킹 채널(111)에 삽입된 후 벌룬(131)이 팽창하여 워킹 채널(111)의 내면과 밀착함으로써 IRE 프로브(130a)가 고정된다. 도시되지는 않았으나, IRE 프로브(130a)에는 벌룬(131)으로 에어를 공급하기 위한 에어 채널이 형성된다. Each of the two IRE probes 130a and 130b is made of a flexible material to enable steering in the form of a long extending wire rod. Since the two IRE probes 130a and 130b have a configuration of a conventional IRE probe, detailed description thereof will be omitted. Each of the two IRE probes 130a and 130b is accommodated in the working channel 111 and extends along the working channel 111, and the tip portion protrudes from the tip of the endoscope tube 110 to further extend. A high electric current flows through each of the two IRE probes 130a and 130b to form a strong electric field between both ends, whereby malignant neoplasms such as cancer are cauterized and removed. Each of the two IRE probes 130a and 130b has a steerable structure, which can be realized using a conventional steering method using a steering wire or the like. Through the steering of the two IRE probes (130a, 130b) the distance (d) between each tip is adjusted to enable a change in the magnetic pole range. Each of the two IRE probes 130a and 130b is inserted through the inlet 121 formed in the body 120 to pass through the working channel 111 of the endoscope tube 110, and two IRE probes 130a and 130b. Each needs to be fixed so as not to move within the working channel 111 of the endoscope 110 for effective interaction with the endoscope 110 during surgery. To this end, fixing means are provided in each of the two IRE probes 130a and 130b. In FIG. 3, one of the two IRE probes 130a and 130b is provided by the fixing means in the working channel 111. The fixed state is shown representatively. Referring to FIG. 3, the fixing means for fixing the IRE probe 130a in the working channel 111 is a balloon 131 provided in the IRE probe 130a, and the IRE probe 130a is a working channel ( After being inserted into 111, the balloon 131 expands to closely contact the inner surface of the working channel 111, thereby fixing the IRE probe 130a. Although not shown, an air channel for supplying air to the balloon 131 is formed in the IRE probe 130a.

IRE 조작부(140)는 IRE 프로브(130)의 후단에 연결되어서, IRE 프로브(130a, 130b)의 작동에 필요한 조작부가 설치된다. 구체적으로 IRE 조작부(140)에는 IRE 프로브(130a, 130b)로 수술을 위한 전기를 공급하는 조작부, 조향을 위한 조작부 및 벌룬(131)으로 에어를 공급하기 위한 조작부가 마련될 수 있다. IRE 조작부(140)는 몸체부(120)의 입구부(121) 외부에 위치하게 된다.The IRE operation unit 140 is connected to the rear end of the IRE probe 130, and an operation unit necessary for the operation of the IRE probes 130a and 130b is installed. In detail, the IRE manipulation unit 140 may be provided with an operation unit for supplying electricity for surgery to the IRE probes 130a and 130b, an operation unit for steering, and an operation unit for supplying air to the balloon 131. The IRE manipulation unit 140 is positioned outside the inlet portion 121 of the body portion 120.

이상 실시예를 통해 본 발명을 설명하였으나, 본 발명은 이에 제한되는 것은 아니다. 상기 실시예는 본 발명의 취지 및 범위를 벗어나지 않고 수정되거나 변경될 수 있으며, 본 기술분야의 통상의 기술자는 이러한 수정과 변경도 본 발명에 속하는 것임을 알 수 있을 것이다.Although the present invention has been described through the above embodiments, the present invention is not limited thereto. The above embodiments may be modified or changed without departing from the spirit and scope of the present invention, and those skilled in the art will recognize that such modifications and changes also belong to the present invention.

100 : IRE 장치
110 : 내시경관
111 : 워킹 채널
120 : 몸체부
130a, 130b : IRE 프로브
131 : 벌룬
140 : IRE 조작부100: IRE device
110: endoscope
111: working channel
120: body
130a, 130b: IRE probe
131 balloon
140: IRE control panel

Claims (1)

내부에 형성된 워킹 채널(111)을 구비하는 내시경관(110);
상기 워킹 채널의 내부에 수용되며, 유연한 재질로 이루어지는 두 IRE 프로브(130a, 130b);
상기 워킹 채널의 후단에 결합되는 조작부; 및
상기 워킹 채널 내에서 상기 두 IRE 프로브 중 하나의 IRE 프로브(130a)에는 고정 수단이 마련되고, 상기 고정 수단은 상기 IRE 프로브(130a)의 외부에 마련되는 벌룬(131)이며, 상기 벌룬은 에어를 공급하는 에어 채널과 연결되며,
상기 벌룬은 팽창되어서 상기 워킹 채널의 내면과 밀착되고,
상기 IRE 프로브는 스터어링 와이어에 의해 조향되고, 각 선단의 서로 이웃하는 거리가 조절되어서 자극 범위의 변경이 가능하며,
상기 내시경관은,
내시경 카메라를 위한 광학 채널, 약물 주입을 위한 유체 채널 및 조명을 위한 조명채널을 더 구비하고,
상기 조작부는,
수술을 위한 전기를 공급하는 조작부, 조향을 위한 조작부 및 상기 벌룬으로 에어를 공급하는 상기 에어채널을 조작하는 조작부를 구비하고,
상기 두 IRE 프로브는
각각에 고전류를 흐르게 하여 양 선단 사이에 자기장이 형성되어 악성신생물을 세포단위로 소작하는 것을 특징으로 하는 비가역적 전기천공법 장치.An endoscope tube 110 having a working channel 111 formed therein;
Two IRE probes 130a and 130b accommodated in the working channel and made of a flexible material;
An operation unit coupled to a rear end of the working channel; And
A fixing means is provided in one IRE probe 130a of the two IRE probes in the working channel, and the fixing means is a balloon 131 provided outside the IRE probe 130a. Connected to the supply air channel,
The balloon is inflated to be in close contact with the inner surface of the working channel,
The IRE probe is steered by a steering wire, the distance between the adjacent ends of each tip is adjusted to change the magnetic pole range,
The endoscope is,
Further comprising an optical channel for an endoscope camera, a fluid channel for drug injection and an illumination channel for illumination,
The operation unit,
An operation unit for supplying electricity for surgery, an operation unit for steering, and an operation unit for operating the air channel for supplying air to the balloon,
The two IRE probes
An irreversible electroporation apparatus, characterized in that a magnetic field is formed between both ends by allowing a high current to flow through, thereby cauterizing malignant neoplasms by cell units.
KR1020190132008A 2019-10-23 2019-10-23 Irreversible electroporation device KR20190122627A (en)

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102385845B1 (en) 2020-12-15 2022-04-12 (주)더스탠다드 Irreversible electroporation system and method
KR20220049299A (en) * 2020-10-14 2022-04-21 인하대학교 산학협력단 Irreversible electroporation device for endoscopy
RU2771638C1 (en) * 2020-06-29 2022-05-11 Байосенс Вебстер (Изрэйл) Лтд. Assessment of the development of ablation by the irreversible electroporation method based on the amplitude of measured biopolar signals

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
미국 공개특허 US 2009/0062788 A1 "ELECTRICAL ABLATION SURGICAL INSTRUMENT" (2009.05.05.)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2771638C1 (en) * 2020-06-29 2022-05-11 Байосенс Вебстер (Изрэйл) Лтд. Assessment of the development of ablation by the irreversible electroporation method based on the amplitude of measured biopolar signals
KR20220049299A (en) * 2020-10-14 2022-04-21 인하대학교 산학협력단 Irreversible electroporation device for endoscopy
KR102385845B1 (en) 2020-12-15 2022-04-12 (주)더스탠다드 Irreversible electroporation system and method

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