KR20180058997A - Pharmaceutical composition and food composition for preventing the growth of white hair or promoting the growth of black hair, and a process for preparing them - Google Patents
Pharmaceutical composition and food composition for preventing the growth of white hair or promoting the growth of black hair, and a process for preparing them Download PDFInfo
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- KR20180058997A KR20180058997A KR1020160158053A KR20160158053A KR20180058997A KR 20180058997 A KR20180058997 A KR 20180058997A KR 1020160158053 A KR1020160158053 A KR 1020160158053A KR 20160158053 A KR20160158053 A KR 20160158053A KR 20180058997 A KR20180058997 A KR 20180058997A
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- sesame
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- pine nut
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Classifications
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- A—HUMAN NECESSITIES
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- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/894—Dioscoreaceae (Yam family)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8962—Allium, e.g. garden onion, leek, garlic or chives
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2200/00—Function of food ingredients
- A23V2200/30—Foods, ingredients or supplements having a functional effect on health
- A23V2200/318—Foods, ingredients or supplements having a functional effect on health having an effect on skin health and hair or coat
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Abstract
Description
본 발명은 백발생성 억제 또는 흑모생성 촉진용 약학 조성물, 식품 조성물 및 그 제조방법에 관한 것으로, 보다 구체적으로는 백발방지 또는 흑모생성 효과가 현저히 우수하고 매우 안전하게 사용될 수 있는 신규한 생약의 조합을 포함하는 백발생성 억제 또는 흑모생성 촉진용 약학 조성물, 식품 조성물 및 그 제조방법에 관한 것이다.The present invention relates to a pharmaceutical composition, a food composition and a preparation method thereof for inhibiting gray hair formation or promoting the production of a black hair, and more specifically, a novel combination of herbal medicine which is remarkably excellent in the effect of preventing gray hair , A food composition and a process for producing the same.
백발이 생기는 기전은 명확하게 규명되어 있지는 않지만, 모낭에서의 멜라닌 생성세포의 감소와 활성화 부재를 원인으로 보고 있다. 멜라닌 생성세포 내에서 멜라닌 생성을 촉진하는 효소인 티로신 가수분해효소, 즉 티로시나제(tyrosinase)의 감소나 이들의 작용에 문제가 있어서 일어날 수 있으며, 멜라닌 생성이 정상적으로 이루어진 경우에도, 피질세포의 포식작용에 의한 멜라닌 과립의 이동이 제한되어 발생할 수도 있다. The mechanism by which gray fever occurs is not clearly known, but it is caused by the decrease of melanocytes in the hair follicles and the absence of activation. It can occur because of the decrease of tyrosine hydrolyzing enzyme, tyrosinase, which is an enzyme that promotes melanin production in melanin-producing cells, and that there is a problem in their action, and even when melanin production is normally performed, May result in limited movement of the melanin granules.
백발은 탈모와 같이 그 발생 원인은 다양하며, 대표적으로는 노화 현상에 의한 것이다. 또한, 스트레스, 영양결핍, 약물 부작용 등에 의해 발생할 수도 있다.The causes of gray feathers vary, such as hair loss, and are typically due to aging. It may also be caused by stress, malnutrition, drug side effects, and the like.
백발은 일반적으로 연령이 높아지면 발생하는 것으로, 노령이라는 느낌을 인상 깊게 하고, 특히 젊은 나이에 있어서의 백발은 일반적으로 싫어하는 경향이 있다. 또한, 외모를 중시하는 현대 사회의 분위기 때문에, 백발 및 탈모는 많은 사람들에게 고통을 주고 있다. 그중 매우 많은 사람들이 염색 또는 가발 착용 등의 방법으로 고민을 해결하고 있는 실정이다.The gray hair generally occurs when the age is high, and the feeling of old age is impressed, and the gray hair especially at the young age generally tends to dislike. In addition, because of the modern society's emphasis on appearance, gray hair and hair loss are causing pain for many people. Many of them solve their anxieties by dyeing or wearing wigs.
백발을 감추기 위하여 염색 등에 의해 백발을 검게 염색하는 염색제가 많이 연구되고 있으며, 널리 시판되고 있다. 그러나, 염색은 일시적인 방편으로서 백발의 성장에 의해 곧 다시 염색하지 않으면 흑발을 유지하기 어렵기 때문에 정기적으로 자주 염색해야 하는 불편함이 따른다. 또한, 현재 널리 사용되고 있는 산화형 흑발염색제는 산화제 등의 사용에 의해 피부 자극이 유발되어 피부가 민감한 사람들은 피부자극 부작용으로 고통받거나 염색을 기피하는 경우도 있다. 따라서, 염색 또는 가발 착용과 같은 임시 방편이외에 백발방지 또는 흑모생성 촉진을 위한 보다 지속적이고 근본적인 대책이 필요하다.Many dyeing agents for dyeing gray hair by dyeing or the like to cover gray hair have been extensively studied and widely marketed. However, dyeing is a temporary measure, and it is difficult to maintain the black hair unless it is dyed again soon by the growth of gray hair, so it is inconvenient to regularly dye frequently. In addition, the oxidative type black hair dye which is widely used at present is caused by skin irritation caused by the use of an oxidizing agent or the like, and people who are sensitive to the skin may suffer skin irritation adverse effects or avoid dyeing. Therefore, in addition to temporary measures such as dyeing or wearing wigs, more persistent and fundamental measures are needed for the prevention of gray hair or for promoting black hair growth.
특허문헌 1는 아미노시클로헥산카르복실산, 아미노시클로헥산카르복실산에스테르 등의 아미노시클로헥산카르복실산에스테르, 아미노시클로헥산올 등의 아미노시클로헥산 유도체 또는 피페리딘카르복실산, 피페리딘카르복실산에스테르 등의 피페리딘카르복실산에스테르, 히드록시피페리딘 등의 피페리딘 유도체를 유효 성분으로서 함유하는 항백발제를 개시한다.Patent Document 1 discloses an aminocyclohexanecarboxylic acid ester such as aminocyclohexanecarboxylic acid or aminocyclohexanecarboxylic acid ester, an aminocyclohexane derivative such as aminocyclohexanol or a derivative thereof such as piperidinecarboxylic acid, Discloses an anti-whitening agent containing, as an active ingredient, a piperidine carboxylic acid ester such as a benzoic acid ester and a piperidino carboxylic acid ester, and a piperidine derivative such as hydroxypiperidine.
특허문헌 2는 울금; 한련초, 잣껍질, 여정실, 블루베리, 녹각, 창출, 및 주목나무잎 중에서 선택된 1종 이상의 제1 한약재와 법제한 유황 추출물; 및 아미노믹스, 백하수오, 복분자, 천연초, 백년초, 포도액상차, 자색고구마, 액상콜라겐, 호박, 구기자, 숙지황, 영지, 헛개나무, 두충, 오가피, 까마중, 유근피, 및 함초 중에서 선택된 1종 이상의 제2 한약재 추출물을 포함하는 탈모 및 새치 방지용 조성물을 개시한다. Patent Document 2 discloses a method of manufacturing a semiconductor device, At least one first herbal medicine and leguminous sulfur extract selected from the group consisting of Hansikucho, pine bark, lecture room, blueberry, And at least one selected from the group consisting of at least one selected from the group consisting of amino acids, amino acids, amino acids, amino acids, amino acids, amino acids, amino acids, amino acids, amino acids, amino acids, A composition for preventing hair loss and alopecia including a second herbal medicine extract is disclosed.
이외에도 다양한 생약 성분의 조합물을 새치 치료, 백발 억제, 또는 흑발 촉진 등을 위해 사용될 수 있다는 보고가 있다. 그러나, 최근의 백발 억제제의 유효성분은 사람이 체감할 수 있는 효과를 발휘하지 못하고 있는 실정이다. 따라서, 백발억제 및 흑모유발 촉진효과가 탁월한 의약 또는 식품의 연구가 계속적으로 필요하다. In addition, there is a report that a combination of various herbal ingredients can be used for treating cysts, inhibiting gray hair, promoting black hair, and the like. However, recent effective ingredients of the hair growth inhibitor have failed to exert an effect that a person can experience. Therefore, there is a continuing need for study of medicines or foods which are excellent in the suppression of gray hair and promoting the induction of black cohosh.
한편, 참깨는 참깨과(Pedaliaceae) 참깨속(Sesamum)의 1년생 초본식물로서 볶은 참깨나 참기름은 우리나라 식단에서 아주 중요한 조미용 양념 및 식용유지로서 사용되고 있다. 약효로는 동맥경화, 고혈압 및 노화 예방 등으로 알려져 왔고, 참깨에는 리그난류 화합물이 다량 함유되어 있어, 항산화 활성을 나타내는 것으로 보고되어 있다. 또한, 쌀, 참깨 등에 함유되어 있는 기능성분(토코페롤, 리그난, 항산화 천연색소 등)은 생체 내에서 산화억제를 통한 노화억제 및 암 예방기능이 있음이 밝혀지고 있다. On the other hand, Sesame is a one-year-old herbaceous plant of Sesamum (Pedaliaceae) Sesamum. Roasted sesame seeds and sesame oil are used as seasoning sauce and edible oil which are very important in the Korean diet. It has been known that the herbal medicine has been known as atherosclerosis, hypertension and prevention of aging, and sesame has been reported to exhibit antioxidative activity because it contains a large amount of turbulent lignin compounds. In addition, it has been found that functional ingredients (tocopherol, lignan, antioxidant natural pigment, etc.) contained in rice, sesame and the like have antioxidative and anti-cancer functions through inhibition of oxidation in vivo.
마(Dioscorea batatas)는 마과에 속하는 다년생 덩굴식물로서, 뿌리를 식용하는데 서여(薯岳) 또는 산약(山藥)이라고도 한다. 마는 전통적으로 消渴에 脾胃의 氣를 補하며 生津하는 목적으로 주로 사용하여 왔고 최근 연구에 의하면 산화적 손상에 대한 항산화작용 및 항염증 작용 등이 보고되어 있다.The mosquito (Dioscorea batatas) is a perennial vine plant belonging to the myrtaceae. It is also known as 孝 岳 or 山药 for edible roots. It has traditionally been used mainly for the purpose of supplementation of 脾 胃 气 for 渴고, and recent studies have reported antioxidant and anti-inflammatory effects against oxidative damage.
잣은 잣나무(Pinus koraiensis)의 종자로서, 잣에는 지방유가 약 74％ 정도 들어 있고 그 주성분은 올레인산·리놀렌산이다. 약성은 온화하고 맛이 달다. 오래 먹으면 노인성변비에 장의 유동운동을 촉진시키면서 배변을 용이하게 하는 효과가 있는 것으로 알려져 있다. Pine nuts are seeds of Pinus koraiensis, which contains about 74% of the oil and its main component is oleic acid and linolenic acid. Mildness is mild and tastes sweet. It has been known that eating long time has the effect of facilitating the bowel movement while promoting the flow of the bowel to the geriatric constipation.
마늘(Allium sativum for. pekinese)은 백합과(Liliaceae)에 속하는 다년생 초본으로 그 인경(鱗莖)을 건조하여 사용하고, 알리신(allicin) 및 다종의 알릴(allyl)기, 프로필(propyl)기, 메틸(methyl)기를 가진 유황화합물이 들어 있다. 마늘은 이뇨, 살균, 살충, 강장의 효과 뿐만아니라 소화액의 분비를 촉진시키는 작용도 나타내며, 신경계통을 자극하여 혈액순환을 왕성하게 하는 효과가 있다(비특허문헌 1). Garlic (Allium sativum for pekinese) is a perennial plant belonging to Liliaceae which is dried and used as a herb, and contains allicin and various allyl, propyl, methyl (methyl) group. Garlic also has the effect of promoting the secretion of digestive juices as well as the effect of diuretic, sterilization, insecticide and tincture, and stimulates the nervous system to vigorously circulate blood (Non-Patent Document 1).
본 발명의 목적은 효과적이고 안전한 백발생성 억제 또는 흑모생성 촉진용 약학 조성물을 제공하는 것이다. It is an object of the present invention to provide an effective and safe pharmaceutical composition for inhibiting white coat formation or promoting black hair formation.
본 발명의 목적은 효과적이고 안전한 백발생성 억제 또는 흑모생성 촉진용 약학 조성물의 제조방법을 제공하는 것이다. It is an object of the present invention to provide a method for producing an effective and safe inhibition of white coat formation or a pharmaceutical composition for promoting black hair growth.
본 발명의 목적은 효과적이고 안전한 백발생성 억제 또는 흑모생성 촉진용 식품 조성물을 제공하는 것이다. It is an object of the present invention to provide an effective and safe food composition for inhibiting white coat formation or promoting black coat formation.
본 발명의 목적은 효과적이고 안전한 백발생성 억제 또는 흑모생성 촉진용 식품 조성물의 제조방법을 제공하는 것이다.It is an object of the present invention to provide a method for producing an effective and safe inhibition of white coat formation or a food composition for promoting black coat formation.
본 발명의 일 양상은 One aspect of the present invention is
참깨, 잣, 마늘, 및 마를 유효성분으로 함유하는 백발생성 억제 또는 흑모생성 촉진용 약학 조성물을 제공한다. Which comprises sesame, pine nut, garlic, and hemp as active ingredients.
본 발명의 다른 일 양상은 In another aspect of the present invention,
참깨, 잣, 마늘, 및 마를 분쇄하는 분말화 단계;A pulverizing step of pulverizing sesame, pine nut, garlic, and hemp;
상기 얻어진 생약의 분말에 결합액을 부가하여 환 형태로 제조하는 단계; Adding a binding liquid to the obtained crude drug powder to prepare a ring form;
제조된 환을 건조하는 단계를 포함하는, And drying the produced ring.
상기 본 발명의 일 양상에 따른 백발생성 억제 또는 흑모생성 촉진용 약학 조성물의 제조방법을 제공한다. There is provided a method for inhibiting the generation of white coat or promoting the production of a black hair according to one aspect of the present invention.
본 발명의 또 다른 일 양상은 In another aspect of the present invention,
참깨, 잣, 마늘, 및 마를 유효성분으로 함유하는 백발생성 억제 또는 흑모생성 촉진용 식품 조성물을 제공한다. Which comprises sesame, pine nut, garlic, and hemp as active ingredients.
본 발명의 또 다른 일 양상은 In another aspect of the present invention,
참깨, 잣, 마늘, 및 마를 분쇄하는 분말화 단계;A pulverizing step of pulverizing sesame, pine nut, garlic, and hemp;
상기 얻어진 생약의 분말에 결합액을 부가하여 환 형태로 제조하는 단계; Adding a binding liquid to the obtained crude drug powder to prepare a ring form;
제조된 환을 건조하는 단계를 포함하는, And drying the produced ring.
상기 본 발명의 일 양상에 따른 백발생성 억제 또는 흑모생성 촉진용 식품 조성물의 제조방법을 제공한다. There is provided a method for producing a food composition for inhibiting white coat formation or promoting black coat formation according to one aspect of the present invention.
본 발명의 일 양상에 따른 약학 조성물 및 식품 조성물은 백발생성 억제 및 흑모생성 촉진 효과뿐만 아니라, 부수적으로 변비 및 소화 불량에도 효과적인 것으로 확인되었다. 따라서, 상기 약학 조성물 및 식품 조성물은 백발생성 억제 및 흑모생성 촉진 효과 이외에 동시에 변비 치료 또는 예방 효과 및 소화 촉진 효과를 나타낼 수 있어 동시에 다양한 효과를 획득할 수 있어 바람직하다. The pharmaceutical composition and the food composition according to one aspect of the present invention have been found to be effective not only in suppressing gray hair formation and promoting black hair growth but also incidentally in constipation and indigestion. Accordingly, the pharmaceutical composition and the food composition are preferable because they can exhibit constipation treatment or prevention effect and digestion promoting effect at the same time as they can obtain various effects at the same time, in addition to the effect of suppressing gray hair formation and promoting black hair formation.
이하, 본 발명을 보다 상세하게 설명한다. Hereinafter, the present invention will be described in more detail.
본 발명에서 사용되는 모든 기술용어는, 달리 정의되지 않는 이상, 본 발명의 관련 분야에서 통상의 당업자가 일반적으로 이해하는 바와 같은 의미로 사용된다. 또한, 본 명세서에는 바람직한 방법이나 시료가 기재되나, 이와 유사하거나 동등한 것들도 본 발명의 범주에 포함된다. 또한, 본 명세서에 기재된 수치는 명시하지 않아도 “약”의 의미를 포함하는 것으로 간주한다. 본 명세서에서 어떤 부분이 어떤 구성요소를 "포함" 한다고 할 때, 이는 특별히 반대되는 기재가 없는 한 다른 구성요소를 제외하는 것이 아니라 다른 구성 요소를 더 포함할 수 있는 것을 의미한다. 본 명세서에 참고문헌으로 기재되는 모든 간행물의 내용은 전체가 본 명세서에 참고로 통합된다. All technical terms used in the present invention are used in the sense that they are generally understood by those of ordinary skill in the relevant field of the present invention unless otherwise defined. In addition, preferred methods or samples are described in this specification, but similar or equivalent ones are also included in the scope of the present invention. Also, the numerical values set forth herein are considered to include the meaning of " about " unless explicitly stated. Whenever a component is referred to as "comprising ", it is understood that it may include other components as well, without departing from the other components unless specifically stated otherwise. The contents of all publications referred to in this specification are incorporated herein by reference in their entirety.
본 발명자들은 안전하면서도 매우 효과적인 생약 성분 유래의 백발생성 억제 또는 흑모생성 촉진용 조성물의 개발을 위해 연구한 결과, 참깨, 잣, 마늘, 및 마를 조합할 경우 현저히 우수한 백발방지 또는 흑모유발 촉진 효과가 있는 것을 발견하여, 새로운 조성의 백발생성 억제 또는 흑모생성 촉진용 조성물을 개발하였다. The inventors of the present invention have conducted studies to develop a safe and highly effective composition for inhibiting the generation of gray hair or inhibiting the formation of gray hair derived from a herbal composition and as a result found that the combination of sesame, pine nut, garlic, and hemp has remarkably excellent anti- , Thereby developing a composition for inhibiting the generation of white flame of a new composition or for promoting the formation of a black hair.
따라서, 본 발명의 일 양상은 참깨, 잣, 마늘, 및 마를 유효성분으로 함유하는 백발생성 억제 또는 흑모생성 촉진용 약학 조성물을 제공한다. Accordingly, one aspect of the present invention provides a pharmaceutical composition for inhibiting the growth of gray hair or promoting the production of gray hair, which comprises sesame, pine nut, garlic, and hemp as active ingredients.
상기 약학 조성물 중에 함유되는 생약인 참깨, 잣, 마늘, 및 마의 비율은 상기 백발생성 억제 또는 흑모생성 촉진 효과를 나타내기만 하면 그 조합비율이 특별히 한정되는 것은 아니며, 일 구체예에서 상기 참깨 1 중량부에 대해 잣 1~3 중량부, 마늘 2~4 중량부, 및 마 0.5~2 중량부로 함유할 수 있다. The combination ratio of sesame, pine nut, garlic, and hemp contained in the pharmaceutical composition is not particularly limited as long as it exhibits the effect of suppressing gray hair formation or promoting black hair formation. In one embodiment, 1 to 3 parts by weight of pine nut, 2 to 4 parts by weight of garlic and 0.5 to 2 parts by weight of garlic.
상기 약학 조성물은 상기 생약을 그 추출물로서 함유할 수도 있고, 추출과정 없이 그 자체 또는 분쇄물로서 함유할 수도 있다. The pharmaceutical composition may contain the herbal medicine as an extract thereof, or may be contained as the extract itself or as a pulverized product without an extraction process.
상기 생약의 추출물은 물, 탄소수 1 내지 3의 저급알콜, 또는 이들의 혼합용매의 추출물일 수 있으며, 일 구체예에서 상기 추출물은 물 추출물이다. 상기 추출물은 당해 기술분야에 공지되어 있는 임의의 추출방법으로 제조될 수 있다.The extract of the herbal medicine may be water, a lower alcohol having 1 to 3 carbon atoms, or a mixed solvent thereof. In one embodiment, the extract is a water extract. The extract may be prepared by any extraction method known in the art.
상기 통상의 추출법에 의해 얻어지는 생약의 추출물은 바람직하게는 C1-C3 알코올의 추출물일 수 있으며, 보다 바람직하게는 에탄올의 추출물이며, 더욱 바람직하게는 70 내지 100%의 에탄올의 추출물일 수 있다. 용매로 추출 시, 추출 온도는 실온에서 수행할 수도 있으나, 보다 효율적인 추출을 위해서는 가온 조건 하에서 수행할 수 있으며, 바람직하게는 40 내지 80℃의 온도에서 추출할 수 있다. 추출시간은 실온으로 추출 시 72 시간 이상, 가온 조건 하에서는 5 내지 24 시간 동안 수행할 수 있다. The herbal medicine extract obtained by the ordinary extraction method may be an extract of C1-C3 alcohol, more preferably ethanol extract, more preferably 70 to 100% ethanol extract. When extracting with a solvent, the extraction temperature may be carried out at room temperature, but it may be carried out under heating at a temperature of 40 to 80 ° C for more efficient extraction. The extraction time may be at least 72 hours at room temperature and 5 to 24 hours at elevated temperature.
상기한 바와 같은 방법에 의해 추출한 추출물은 그대로 사용할 수도 있으나, 농축한 엑스 형태로 사용될 수도 있고, 농축한 다음 동결 건조하여 동결건조물의 형태로서 사용될 수도 있다. 바람직하게는, 충분한 농도로 사용될 수 있도록 농축된 형태로서 사용한다. The extract extracted by the above-described method may be used as it is or may be used in the form of concentrated extract, or it may be concentrated and then lyophilized and used as a lyophilized product. Preferably, it is used as a concentrated form so that it can be used at a sufficient concentration.
상기 약학 조성물은 참깨, 잣, 마늘, 및 마를 추출과정 없이 생약 자체의 분쇄물 또는 생약의 건조 분쇄물로서 함유할 수도 있다. 분쇄물의 제조방법은 당해 기술분야에 공지되어 있는 임의의 분쇄물 제조방법에 따라 제조될 수 있다. The pharmaceutical composition may contain sesame, pine nut, garlic, and hemp as pulverized products of the herbal medicines themselves or dried pulverized products of herbal medicines without an extraction process. The pulverized product can be produced according to any pulverized product manufacturing method known in the art.
상기 약학 조성물은 당해 기술분야에 공지되어 있는 통상적인 약제학적 제형으로 제제화될 수 있다. 상기 의약품은 경구투여제제, 주사제, 좌제, 경피투여제제, 및 경비투여제제를 포함하지만, 이에 한정되지 않는 임의의 제형으로 제제화되어 투여될 수도 있으나, 바람직하게는 액제, 현탁제, 산제, 과립제, 정제, 캡슐제, 환제, 또는 엑스제와 같은 경구 투여용 제형으로 제제화될 수 있다. 일 구체예에서, 상기 약학 조성물은 환제이다. The pharmaceutical compositions may be formulated into conventional pharmaceutical formulations known in the art. The medicines may be formulated into any formulations including, but not limited to, oral administration formulations, injectable preparations, suppositories, transdermal dosage forms, and expectorant dosage forms. Preferably, the medicines may be formulated as liquid preparations, suspensions, Such as tablets, capsules, pills, or powders, for oral administration. In one embodiment, the pharmaceutical composition is a pill.
상기 각각의 제형으로 제제화 시, 각각의 제형의 제조에 필요한 약제학적으로 허용 가능한 담체 또는 첨가제를 부가하여 제조할 수 있다. 대표적으로 경구 투여용 제형으로 제제화 시 상기 담체로서 희석제, 활택제, 결합제, 붕해제, 감미제, 안정제, 및 방부제 중에서 1 종 이상을 선택하여 사용할 수 있으며, 첨가제로는 향료, 비타민류, 및 항산화제 중에서 1 종 이상을 선택하여 사용할 수 있다. When formulating into each of the above-mentioned formulations, it may be prepared by adding a pharmaceutically acceptable carrier or an additive necessary for the preparation of each of the formulations. Representative examples of the formulations for oral administration include at least one selected from the group consisting of diluents, lubricants, binders, disintegrants, sweeteners, stabilizers, and preservatives as the carrier when formulated. Examples of the additives include perfumes, vitamins, and antioxidants May be selected and used.
상기 담체 및 첨가제는 약제학적으로 허용 가능한 것은 모두 가능하며, 구체적으로 희석제로는 유당, 옥수수 전분, 대두유, 미정질 셀룰로오스, 또는 만니톨, 활택제로는 스테아린산 마그네슘 또는 탈크, 결합제로는 폴리비닐피롤리돈 또는 히드록시프로필셀룰로오스가 바람직하다. 또한, 붕해제로는 카르복시메틸셀룰로오스 칼슘, 전분글리콜산나트륨, 폴라크릴린칼륨, 또는 크로스포비돈, 감미제로는 백당, 과당, 솔비톨, 또는 아스파탐, 안정제로는 카르복시메틸셀룰로오스나트륨, 베타-사이클로덱스트린, 백납, 또는 잔탄검, 방부제로는 파라옥시안식향산메틸, 파라옥시안식향산프로필, 또는 솔빈산칼륨이 바람직하다. Examples of the diluent include lactose, corn starch, soybean oil, microcrystalline cellulose, or mannitol as the diluent, magnesium stearate or talc as the lubricant, polyvinylpyrrolidone as the binder, Or hydroxypropylcellulose are preferable. Examples of the disintegrant include carboxymethylcellulose calcium, sodium starch glycolate, polacrilin potassium, or crospovidone; examples of sweeteners include white sugar, fructose, sorbitol, or aspartame; stabilizers include sodium carboxymethylcellulose, Preferred examples of the antiseptic agent include methyl paraoxybenzoate, propyl paraoxybenzoate, and potassium sorbate.
또한, 상기 성분 이외에도 공지의 첨가제로서 미각을 돋구기 위하여, 매실향, 레몬향, 파인애플향, 허브향 등의 천연향료, 천연과즙, 클로로필린, 플라보노이드 등의 천연색소, 과당, 벌꿀, 당알코올, 설탕과 같은 감미성분, 또는 구연산, 구연산 나트륨과 같은 산미제를 혼합하여 사용할 수도 있다.In addition to the above components, natural additives such as natural flavors such as plum flavor, lemon flavor, pineapple flavor and herb flavor, natural fruit juice, natural coloring matters such as chlorophyllin and flavonoid, fructose, honey, sugar alcohol, sugar Or acidic agents such as citric acid and sodium citrate may be mixed and used.
상기 약학 조성물은 백발방지 또는 흑모유발 촉진 효과를 얻기 위하여, 유효성분으로서 체중 60 kg 성인을 기준으로 1 일 총 투여량이 추출물로서 8 - 50 mg, 생약을 기준으로 1 - 100 g이 되도록 임의로 수회 나누어서 경구 투여할 수 있다. 통상적인 환제(1g/환)의 형태로서 투여 시, 1회에 약 1 - 20 개, 1일 3회 투여할 수 있다.In order to obtain the effect of promoting the prevention of gray fever or black fever, the pharmaceutical composition is divided into several times so that the total dose per day as an active ingredient is 8 to 50 mg as an extract and 1 to 100 g as an active ingredient, Orally. When administered in the form of a conventional pill (1 g / ring), it can be administered about 1 to 20 times a day, three times a day.
상기 투여량은 백발의 진행 정도, 투여 경로, 성별, 나이, 체중, 사용목적(백발생성 억제 및 흑모유발 촉진) 등에 따라 달라질 수 있으며 전문가의 판단에 따라 가감될 수 있다.The dose may vary depending on the progression of gray hair, route of administration, sex, age, body weight, purpose of use (inhibition of gray hair formation and promotion of black cohosh), and may be adjusted according to expert judgment.
상기 약학 조성물을 백발로 고민하는 40대 내지 50대의 건강한 여성 및 남성을 대상으로 1 회에 10 개, 1 일 3 회 약 90일 투여한 다음, 백발생성 억제 및 흑모유발 촉진 효과를 평가한 결과, 대부분의 사람으로부터 백발생성 억제 및 흑모생성 촉진 효과를 얻을 수 있는 것으로 나타났다(시험예 1 및 2 참조). As a result of evaluating the inhibition of gray hair formation and promoting the induction of black cohort, after administering 10 times at a time and three times a day for about 90 days to healthy female and male of 40 to 50 years old who suffered from the above-mentioned pharmaceutical composition, It was found that most people inhibited the formation of gray hair and the effect of promoting black hair formation (see Test Examples 1 and 2).
상기 약학 조성물은 참깨, 잣, 마늘, 및 마를 각각 사용할 경우에 비해, 상기 4가지 생약의 조합을 유효성분으로 함유할 경우 현저히 우수한 상승적인 백발생성 억제 및 흑모생성 촉진 효과를 가질 수 있다. Compared to the case where sesame, pine nut, garlic, and hemp are each used, the pharmaceutical composition can exhibit remarkably superior synergistic inhibition of white coat formation and promoting black hair formation, when the combination of the four herbal medicines is contained as an active ingredient.
또한, 상기 약학 조성물은 백발생성 억제 및 흑모생성 촉진 효과뿐만 아니라, 부수적으로 변비 및 소화 불량에도 효과적인 것으로 확인되었다. 따라서, 상기 약학 조성물은 백발생성 억제 및 흑모생성 촉진 효과 이외에 동시에 변비 치료 또는 예방 효과 및 소화 촉진 효과를 나타낼 수 있어 동시에 다양한 효과를 획득할 수 있어 바람직하다.In addition, it has been confirmed that the pharmaceutical composition is effective not only in inhibiting gray hair formation and promoting black hair formation but also incidentally in constipation and indigestion. Therefore, the pharmaceutical composition is preferable because it can exhibit constipation treatment or preventive effect and digestion promoting effect at the same time as it can attain various effects at the same time, in addition to the effect of inhibiting gray hair formation and promoting black hair formation.
본 발명의 다른 일 양상은 In another aspect of the present invention,
참깨, 잣, 마늘, 및 마를 분쇄하는 분말화 단계;A pulverizing step of pulverizing sesame, pine nut, garlic, and hemp;
상기 얻어진 생약의 분말에 결합액을 부가하여 환 형태로 제환하는 단계; Adding a binding liquid to the powder of the obtained herbal medicine to replenish it in a ring form;
제환된 환을 건조하는 단계를 포함하는, 상기 본 발명에 따른 백발생성 억제 또는 흑모생성 촉진용 약학 조성물의 제조방법을 제공한다. And a step of drying the puffed ring. The present invention also provides a method for producing a pharmaceutical composition for inhibiting gray hair formation or promoting the production of black hair, comprising the steps of:
상기 백발생성 억제 또는 흑모생성 촉진용 약학 조성물의 제조방법의 상세는 상기 본 발명의 일 양상에 따른 백발생성 억제 및 흑모생성 촉진 약학 조성물에 대한 설명이 그대로 적용될 수 있다. The details of the method for producing a pharmaceutical composition for inhibiting gray hair formation or promoting the production of black hair can be applied as it is to the description of the inhibition of gray hair formation and the pharmaceutical composition for promoting black hair formation according to one aspect of the present invention.
상기 결합액은 환제의 제조를 위해 사용될 수 있는 임의의 결합액일 수 있으며, 예를 들어 아라비아고무 가루, 트라가칸타 가루, 시럽/글리세린 (1:1), 고무/포도당액(아라비아고무 가루 20, 포도당 60, 물 50), 봉밀, 젤라틴액, CMC 액, 아라비아고무장, 트라가칸타장 등이 있으며, 이에 한정되는 것은 아니다. The binding liquid may be any binding liquid which can be used for the preparation of the pills, for example, arabic rubber powder, tragacanthar powder, syrup / glycerin (1: 1), rubber / glucose solution (gum arabic powder 20, Glucose 60, water 50), barley, gelatin solution, CMC solution, gum arabic, tragacanth, and the like.
상기 환제의 제조를 위해, 선택적으로 부형제, 붕해제, 또는 이들의 조을 상기 결합제와 함께 추가로 부가할 수 있다. 상기 부형제는 환제의 제조를 위해 사용될 수 있는 임의의 부형제일 수 있으며, 예를 들어 포도당, 유당, 전분류, 생약가루 및 생약엑스류, 유성물질, 무기물질 등이 있다. 상기 붕해제는 환제의 제조를 위해 사용될 수 있는 임의의 붕해제일 수 있으며, 예를 들어 라미나리아, 한천, 약용 효모 등이 있다. Optionally, excipients, disintegrants, or combinations thereof may be further added with the binder for the production of the pellets. The excipient may be any excipient that can be used for the manufacture of the pill, such as glucose, lactose, pre-classified, herbal powder and herbal extracts, oil-based materials, and inorganic materials. The disintegrant can be any disintegrant that can be used for the production of the pills, such as laminaria, agar, medicinal yeast, and the like.
제환된 환을 건조하는 단계는 통상적인 환제의 건조방법에 따라 수행할 수 있으며, 일 구체예서 상기 건조는 실온에서 그늘에서 자연건조 한다.The step of drying the poured ring can be carried out according to a conventional method of drying the pills, and the drying is naturally dried in a shade at room temperature.
본 발명의 또 다른 일 양상은 In another aspect of the present invention,
참깨, 잣, 마늘, 및 마를 유효성분으로 함유하는 백발생성 억제 및 흑모생성 촉진용 식품 조성물을 제공한다. Which comprises sesame, pine nut, garlic, and hemp as effective ingredients, and a food composition for promoting the inhibition of gray hair formation and promotion of black hair formation.
상기 식품 조성물의 상세는, 약학 조성물이 식품인 것만을 제외하고는 상기 본 발명의 일 양상에 따른 약학 조성물에 대한 설명이 그대로 적용될 수 있다.The details of the food composition may be applied to the pharmaceutical composition according to one aspect of the present invention, except that the pharmaceutical composition is a food.
상기 식품 조성물의 복용량은 특별히 한정되는 것은 아니나, 유효성분으로서 체중 60 kg 성인을 기준으로 1 일 총 투여량이 추출물로서 8 - 50 mg, 생약을 기준으로 1 - 100 g이 되도록 임의로 수회 나누어서 경구 투여할 수 있다. 통상적인 환제의 형태로서 투여 시, 1회에 약 1 - 20 개, 1일 3회 투여할 수 있다. 상기 투여량은 백발의 진행 정도, 성별, 나이, 체중, 사용목적(예방 또는 개선, 육모) 등에 따라 달라질 수 있으며 적절히 가감될 수 있다. The dose of the food composition is not particularly limited, but it is optionally administered orally divided into several times so that a total daily dose of 8 to 50 mg as an extract and 1 to 100 g as a medicament based on a 60 kg body weight as an active ingredient . As a typical form of pills, about 1 to 20 pills can be administered at a time, three times a day. The dosage may vary depending on the progress of the gray hair, sex, age, body weight, purpose of use (prevention or improvement, hair growth), and may be appropriately added or subtracted.
상기 식품 조성물은 건강기능식품으로서 사용될 수 있다. "건강기능식품"이라 함은 건강기능식품에 관한 법률 제6727호에 따른 인체에 유용한 기능성을 가진 원료나 성분을 사용하여 제조 및 가공한 식품을 의미하며, "기능성"이라 함은 인체의 구조 및 기능에 대하여 영양소를 조절하거나 생리학적 작용 등과 같은 보건 용도에 유용한 효과를 얻을 목적으로 섭취하는 것을 의미한다.The food composition may be used as a health functional food. "Health functional food" refers to foods prepared and processed using raw materials or ingredients having useful functions in the human body pursuant to Law No. 6727 on Health Functional Foods, and the term "functional" It is intended to take nutrients for the purpose of controlling nutrients and obtaining effects that are useful for health use such as physiological action.
상기 식품 조성물은 통상의 식품 첨가물을 포함할 수 있으며, "식품 첨가물"로서의 적합 여부는 다른 규정이 없는 한, 식품의약품안정청에 승인된 식품 첨가물 공전의 총칙 및 일반시험법 등에 따라 해당 품목에 관한 규격 및 기준에 의하여 판정한다.The above food composition may contain conventional food additives. Unless otherwise specified, the suitability of the food additive as a "food additive" shall be determined by the Food and Drug Administration in accordance with the General Regulations of the Food Additives Ordinance and the General Test Methods, And standards.
상기 "식품 첨가물 공전"에 기재된 품목으로는 예를 들어, 케톤류, 글리신, 구연산칼륨, 니코틴산, 계피산 등의 화학적 합성물, 감색소, 감초추출물, 결정셀룰로오스, 고량색소, 구아검 등의 천연첨가물, L-글루타민산나트륨 제제, 면류첨가알칼리제, 보존료제제, 타르색소제제 등의 혼합제제류들을 들 수 있다. Examples of the substances described in the above-mentioned "Food Additive Code" include natural compounds such as ketones, chemical compounds such as glycine, potassium citrate, nicotinic acid and cinnamic acid, persimmon extracts, licorice extract, crystalline cellulose, high- - Mixed preparations such as a sodium glutamate preparation, a noodle-added alkaline agent, a preservative preparation, a tar coloring agent and the like.
상기 건강기능식품은 예를 들어 산제, 과립제, 정제, 환제, 캡슐제, 현탁액, 유제, 시럽제, 침제, 액제, 엑스제 등의 일반적인 제형으로 제조될 수도 있고, 육류, 소세지, 빵, 쵸코렛, 캔디류, 스넥류, 과자류, 피자, 라면, 기타 면류, 껌류, 젤리, 아이스크림류를 포함한 낙농제품, 각종 스프, 음료수, 차, 드링크제, 알콜 음료 및 비타민 복합제 등의 임의의 건강기능식품 형태로 제조될 수도 있다. 상기 건강기능식품의 제제화를 위해 식품학적으로 허용 가능한 담체 또는 첨가제를 사용할 수 있으며, 제조하고자 하는 제형의 제조에 당해 기술분야에서 사용 가능한 것으로 공지되어 있는 임의의 담체 또는 첨가제가 이용될 수 있다. The health functional food may be prepared by a common formulation such as a powder, granule, tablet, pill, capsule, suspension, emulsion, syrup, , Beverages, tea, drinks, alcoholic beverages and vitamin complexes, such as, for example, beverages, snacks, snacks, confectionery, pizza, ramen, other noodles, gums, jellies, ice creams, . A pharmaceutically acceptable carrier or additive may be used for the formulation of the health functional food, and any carrier or additive known to be usable in the art for the preparation of the formulation to be produced may be used.
일 구체예에서, 상기 건강기능식품은 환제이다. In one embodiment, the health functional food is a pill.
상기 첨가제로서 각종 영양제, 비타민, 전해질, 풍미제, 착색제, 펙트산 및 그의 염, 알긴산 및 그의 염, 유기산, 보호성 콜로이드 증점제, pH 조절제, 안정화제, 방부제, 글리세린, 알콜, 탄산 음료에 사용되는 탄산화제 등을 함유할 수 있다. 그 이외에도 천연 과일쥬스, 과일쥬스 음료 및 야채 음료의 제조를 위한 과육을 함유할 수 있다. 이러한 첨가제 성분은 독립적으로 또는 조합하여 사용할 수 있으며, 첨가제의 비율은 크게 중요하진 않지만 상기 건강기능식품용 조성물 100 중량부당 0.01 ~ 0.1 중량부의 범위에서 선택될 수 있다.As the above-mentioned additives, there can be used various nutrients, vitamins, electrolytes, flavors, colorants, pectic acids and salts thereof, alginic acid and its salts, organic acids, protective colloid thickeners, pH adjusting agents, stabilizers, preservatives, glycerin, Carbonating agents, and the like. In addition, it may contain natural fruit juice, fruit juice beverage and flesh for the production of vegetable beverages. These additive components may be used independently or in combination, and the proportion of the additive is not critical, but may be selected in the range of 0.01 to 0.1 parts by weight per 100 parts by weight of the composition for health functional foods.
상기 음료는 상기 활성성분 이외의 다른 성분을 더 포함할 수 있으며, 통상적으로 음료에 사용되는 다양한 향미제 또는 천연 탄수화물 등을 더 함유할 수 있다. 상기 천연 탄수화물로는 단당류(예: 포도당, 과당 등), 이당류(예: 말토즈, 수크로즈 등), 다당류(예: 덱스트린, 시클로덱스트린 등)와 같은 통상적인 당 및 자일리톨, 소르비톨, 에리트리톨 등의 당알콜이 함유될 수 있다. 또한, 향미제로서 천연 향미제(예: 타우마틴, 스테비아 추출물 등) 및 합성 향미제(예: 사카린, 아스파탐 등)를 함유할 수 있다. 상기 천연 탄수화물의 비율은 음료 100 mL당 일반적으로 약 1 내지 20g, 바람직하게는 약 5 내지 12g으로 함유되는 것이 바람직하다.The beverage may further contain ingredients other than the above-mentioned active ingredients, and may further contain various flavors or natural carbohydrates commonly used in beverages. Examples of the natural carbohydrate include conventional sugars such as monosaccharides such as glucose and fructose; disaccharides such as maltose and sucrose; polysaccharides such as dextrin and cyclodextrin; and sugars such as xylitol, sorbitol, erythritol, Of sugar alcohols may be contained. In addition, as a flavoring agent, a natural flavoring agent (e.g., tau Martin, stevia extract, etc.) and a synthetic flavoring agent (e.g., saccharin, aspartame, etc.) may be contained. The ratio of the natural carbohydrate is preferably about 1 to 20 g, preferably about 5 to 12 g per 100 mL of beverage.
상기 식품 조성물은 백발생성 억제 및 흑모생성 촉진 효과 뿐만 아니라, 부수적으로 변비, 소화 불량에도 효과적이다. 따라서, 상기 식품 조성물은 백발생성 억제 및 흑모생성 촉진 효과 이외에 동시에 변비 개선 또는 예방 효과 및 소화 촉진 효과를 나타낼 수 있어 동시에 다양한 효과를 획득할 수 있다는 장점이 있다. The food composition is effective not only in inhibiting the generation of gray hair and promoting the formation of black blood, but also in constipation and indigestion. Therefore, the food composition has the advantage of being able to exhibit constipation improvement or prevention effect and digestion promotion effect at the same time in addition to the effect of suppressing the gray hair formation and promoting the black hair formation, and to obtain various effects at the same time.
본 발명의 또 다른 일 양상은 In another aspect of the present invention,
참깨, 잣, 마늘, 및 마를 분쇄하는 분말화 단계;A pulverizing step of pulverizing sesame, pine nut, garlic, and hemp;
상기 얻어진 생약의 분말에 결합액을 부가하여 환 형태로 제조하는 단계; Adding a binding liquid to the obtained crude drug powder to prepare a ring form;
제조된 환을 건조하는 단계를 포함하는, 상기 본 발명에 따른 백발생성 억제 또는 흑모생성 촉진용 식품 조성물의 제조방법을 제공한다. And a step of drying the prepared ring, wherein the method comprises the step of drying the prepared ring.
상기 백발생성 억제 또는 흑모생성 촉진용 식품 조성물의 제조방법의 상세는 상기 본 발명의 일 양상에 따른 백발생성 억제 또는 흑모생성 촉진용 식품 조성물에 대한 설명이 그대로 적용될 수 있다. The detailed description of the method for producing the food composition for inhibiting the gray hair formation or promoting the formation of the black hair may be applied to the description of the food composition for inhibiting gray hair formation or promoting black hair formation according to one aspect of the present invention.
이하, 본 발명을 하기 실시예에 의해 더욱 구체적으로 설명한다. 그러나, 이들 실시예는 본 발명에 대한 이해를 돕기 위한 것일 뿐, 어떤 의미로든 본 발명의 범위가 이들에 의해 제한되는 것은 아니다. Hereinafter, the present invention will be described in more detail with reference to the following examples. However, these embodiments are provided to aid understanding of the present invention, and the scope of the present invention is not limited thereto in any sense.
실시예Example 1: One: 환제의Pennant 제조(1) Manufacturing (1)
참깨, 잣, 마늘, 및 마 각각의 원료에서 이물질을 선별한 후 깨끗하게 씻은 후 그늘에서 음건하였다. 상기 참깨는 50 ℃에서 10 분 동안 가열하여 분쇄한 후, 참깨분말을 제조하고, 음건된 잣, 마늘, 및 마는 분말화하여 준비하였다. Sesame seeds, pine nuts, garlic, and hemp were screened for foreign materials from each raw material, cleaned, and shaded in shade. The sesame was crushed by heating at 50 DEG C for 10 minutes, and then sesame powder was prepared and shredded pine nuts, garlic, and hemp powder were prepared.
이후에, 상기 참깨분말 1 kg, 잣 분말 2 kg, 마늘 분말 3 kg, 및 마 분말 1 kg을 혼합하였다. 이후에 상기 분말 혼합물 100 중량부에 대하여 꿀 50 중량부를 혼합하여 환 제형의 생약 혼합물을 제조하였다. 상기 혼합물로부터 환 형태를 제조하고(1g/환), 제조된 환을 실온의 그늘에서 충분히 건조하여 환을 완성하였다. Then, 1 kg of the sesame powder, 2 kg of pine powder, 3 kg of garlic powder, and 1 kg of hemp powder were mixed. Then, 50 parts by weight of honey was mixed with 100 parts by weight of the powder mixture to prepare a crude drug mixture. A ring form was prepared from the mixture (1 g / ring) and the resulting ring was sufficiently dried at room temperature in the shade to complete the ring.
실시예Example 2: 2: 환제의Pennant 제조(2) Manufacturing (2)
상기 실시예 1에서, 참깨분말 1 kg, 잣 분말 3 kg, 마늘 분말 4 kg, 및 마 분말 2 kg을 혼합하는 것을 제외하고 실시예 1과 동일한 방법으로 하여 환을 완성하였다. In Example 1, a ring was completed in the same manner as in Example 1, except that 1 kg of sesame powder, 3 kg of pine powder, 4 kg of garlic powder and 2 kg of hemp powder were mixed.
실시예Example 3: 3: 환제의Pennant 제조(3) Manufacturing (3)
상기 실시예 1에서, 참깨분말 1 kg, 잣 분말 1 kg, 마늘 분말 2 kg, 및 마 분말 0.5 kg을 혼합하는 것을 제외하고 실시예 1과 동일한 방법으로 하여 환을 완성하였다.In Example 1, the ring was completed in the same manner as in Example 1, except that 1 kg of sesame powder, 1 kg of pine powder, 2 kg of garlic powder and 0.5 kg of hemp powder were mixed.
비교예Comparative Example 1: One: 환제의Pennant 제조(4) Manufacturing (4)
상기 실시예 1에서, 4가지 생약성분 조합 대신 오직 참깨분말 7 kg만을 혼합하는 것을 제외하고 실시예 1과 동일한 방법으로 하여 환을 완성하였다.In Example 1, the ring was completed in the same manner as in Example 1, except that only 7 kg of sesame powder was mixed instead of four herbal ingredients.
비교예Comparative Example 2: 2: 환제의Pennant 제조(5) Manufacturing (5)
상기 실시예 1에서, 4 가지 생약성분 조합 대신 오직 잣 7 kg만을 혼합하는 것을 제외하고 실시예 1과 동일한 방법으로 하여 환을 완성하였다.In Example 1, the ring was completed in the same manner as in Example 1, except that only 7 kg of pine nut was mixed instead of four herbal ingredients.
비교예Comparative Example 3: 3: 환제의Pennant 제조(6) Manufacturing (6)
상기 실시예 1에서, 4 가지 생약성분 조합 대신 오직 마늘분말 7 kg만을 혼합하는 것을 제외하고 실시예 1과 동일한 방법으로 하여 환을 완성하였다.In Example 1, the ring was completed in the same manner as in Example 1, except that only 7 kg of garlic powder was mixed instead of four herbal ingredients.
비교예Comparative Example 4: 4: 환제의Pennant 제조(7) Manufacturing (7)
상기 실시예 1에서, 4 가지 생약성분 조합 대신 오직 마분말 7 kg만을 혼합하는 것을 제외하고 실시예 1과 동일한 방법으로 하여 환을 완성하였다.In Example 1, the ring was completed in the same manner as in Example 1, except that only 7 kg of flour powder was mixed instead of four herbal ingredients combinations.
실험예Experimental Example 1: 백발비율 감소 효과 임상시험(1) 1: Reducing the rate of white coat rate Clinical trial (1)
상기 실시예 1에서 제조한 환제를 백발로 고민하는 40대 내지 50대의 건강한 성인(여성 5명, 남성 5명)을 대상으로 백발의 비율 감소 효과를 시험하였다. 구체적으로는, 1 회에 10 개, 1 일 3 회 약 90일간 복용하도록 하였다.The effect of decreasing the rate of gray hair was examined in healthy adults (5 females, 5 males) of 40 to 50 years old who were suffering from the puffiness of the pill produced in Example 1 above. Specifically, 10 times at a time, and three times a day for about 90 days.
보름 뒤부터 15일 간격으로 원래 백발이 있던 머리 부위 사진을 촬영하도록 하였다. A photograph of the head where the original gray hair was present was taken at intervals of 15 days from the post-menopause.
그 결과, 복용 후 1 개월째부터 백발의 비율이 서서히 감소하는 효과가 확인되었으며, 복용 후 90 일째에는 백발의 비율에 처음에 비해 확연히 줄어드는 것이 육안으로 확인되었다. As a result, it was confirmed that the ratio of gray hair decreased gradually from the first month after the administration, and that the percentage of gray hair decreased sharply at the 90th day after the administration.
실험예Experimental Example 2: 백발비율 감소 효과 임상시험(2) 2: Reducing the rate of gray hair Clinical trial (2)
상기 실시예 1 내지 3 및 비교예 1 내지 4에서 제조한 환제를 백발로 고민하는 40대 내지 50대의 건강한 성인을 대상으로 백발의 비율 감소 효과를 시험하였다. 구체적으로는, 각 시험군당 10명의 대상으로 1 회에 10 개, 1 일 3 회 약 90일간 복용하도록 하였다.The effect of decreasing the ratio of white hair to healthy adults of 40 to 50 years in which the pellets prepared in Examples 1 to 3 and Comparative Examples 1 to 4 were suffering from gray fever was tested. Specifically, 10 test subjects per test group were administered 10 times at a time and 3 times a day for about 90 days.
백발생성 억제 및 흑모유발 촉진효과의 판정은 상기 환제를 복용한 후, 피험자 개인의 주관적 평가로 하기 평가점수 기준을 통해 백발의 감소 정도를 평가하도록 하였다.The inhibition of the gray hair formation and the evaluation of the effect of promoting the black hair induction were evaluated by subjective evaluation of individual subjects after taking the above-described pills, by evaluating the degree of decrease of gray hair through the following evaluation score criteria.
그 결과, 실시예 1-3의 경우 대부분의 사람으로부터 만족할 만한 백발 감소 효과를 나타내었으므로, 백발생성 억제 및 흑모생성 촉진 효과가 확인되었다. As a result, in Examples 1-3, satisfactory reduction of white hair was exhibited from most people, so that inhibition of gray hair formation and promotion of black hair formation were confirmed.
Claims (16)
상기 얻어진 생약의 분말에 결합액을 부가하여 환 형태로 제조하는 단계;
제조된 환을 건조하는 단계를 포함하는, 제 1, 2, 및 5 내지 7 항 중 어느 한 항에 따른 백발생성 억제 또는 흑모생성 촉진용 약학 조성물의 제조방법. A pulverizing step of pulverizing sesame, pine nut, garlic, and hemp;
Adding a binding liquid to the obtained crude drug powder to prepare a ring form;
A method for producing a pharmaceutical composition for inhibiting the production of gray hair or promoting the production of gray hair according to any one of claims 1, 2, and 5 to 7, which comprises drying the manufactured ring.
상기 얻어진 생약의 분말에 결합액을 부가하여 환 형태로 제조하는 단계;
제조된 환을 건조하는 단계를 포함하는, 제 9, 10, 13, 및 14 항 중 어느 한 항에 따른 백발생성 억제 또는 흑모생성 촉진용 식품 조성물의 제조방법. A pulverizing step of pulverizing sesame, pine nut, garlic, and hemp;
Adding a binding liquid to the obtained crude drug powder to prepare a ring form;
9. A method of producing a food composition for inhibiting the generation of white smoke or promoting the production of a black pigment according to any one of claims 9, 10, 13, and 14, which comprises drying the produced ring.
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| CN107773624A (en) * | 2016-08-31 | 2018-03-09 | 西宝生物科技（上海）股份有限公司 | A kind of biological products for blackening hair and preparation method thereof |
| CN111802641A (en) * | 2020-06-09 | 2020-10-23 | 刘淑云 | Composition with effect of relaxing bowel and preparation method and application thereof |
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