KR20180017974A - Cosmetic composition for preventing or treating acne comprising combined herbal extracts - Google Patents
Cosmetic composition for preventing or treating acne comprising combined herbal extracts Download PDFInfo
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- KR20180017974A KR20180017974A KR1020160102696A KR20160102696A KR20180017974A KR 20180017974 A KR20180017974 A KR 20180017974A KR 1020160102696 A KR1020160102696 A KR 1020160102696A KR 20160102696 A KR20160102696 A KR 20160102696A KR 20180017974 A KR20180017974 A KR 20180017974A
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- extract
- preventing
- green tea
- acne
- ginger
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Abstract
Description
본 발명은 복합생약추출물을 유효성분으로 함유하는 여드름 예방 또는 치료용 화장료 조성물에 관한 것으로서, 더욱 상세하게는, 생강 추출물, 양제근 추출물, 녹차 추출물 및 달맞이꽃씨 추출물을 유효성분으로 함유하는 여드름 예방 또는 치료용 화장료 조성물에 관한 것이다.The present invention relates to a cosmetic composition for preventing or treating acne, which comprises a complex herbal medicine extract as an active ingredient, and more particularly, to a cosmetic composition for prevention or treatment of acne containing an active ingredient of ginger extract, root extract, green tea extract and evening primrose extract And more particularly to a cosmetic composition for cosmetics.
피부에는 다양한 미생물들이 존재하여 이 미생물들은 각종 피부 질환을 야기시킨다. 피부에서 화농을 일으키는 스태필로코커스 아우레우스(Staphylococcus aureus)을 비롯한 피부 상재균으로는 스태필로코커스 에피더미스(Staphylococcus epidermis), 프로피오니박테리움 아크네스(Propionibacterium acnes) 등이 있으며 이 균들은 피부상에 분비된 피지나 땀을 분해시켜 분해산물을 발생시키고, 이 분해산물은 염증을 야기시킨다.There are various microorganisms on the skin, and these microorganisms cause various skin diseases. Staphylococcus epidermis, Propionibacterium acnes, and the like are examples of the skin topical bacteria including Staphylococcus aureus which causes the skin to grow in the skin, such as Staphylococcus aureus, The sebum or sweat secreted on the skin decomposes to produce degradation products, which cause inflammation.
여드름의 의학적 명칭은 심상성 좌창으로, 모공에서 피지의 생산이 증가되고 피부 상피세포가 비정상적으로 각화되어 모공의 개구부를 막으며 이곳에 여드름 원인 세균이 증식하여 염증을 발생시킴으로써 유발된다. 여드름은 특히 2차 성 성숙 있는 청소년기에 주로 발병하는 피부질환으로서 11세에서 30세 사이에 약 80%가 발병하고, 30대 이후에서도 약 6%의 환자가 있는 것으로 보고되어 있으며, 최근 들어 스트레스에 의한 여드름으로 20대 이후 발병하는 경우도 있다.The medical name for acne is acne vulgaris, caused by increased production of sebum in the pores, abnormal erosion of the skin epithelium, blocking of the pore opening, and the proliferation of acne-causing bacteria in the pores, causing inflammation. Acne is a skin disease that mainly affects adolescents with secondary sexual maturity. It is reported that about 80% of patients develop skin disease between 11 and 30 years of age, and about 6% Acne caused by the onset in the 20s is also the case.
여드름의 발생 원인을 크게 3가지로 나누어 볼 수 있는데, 첫째는 피지의 과잉생산이다. 성 성숙기에 증가된 호르몬에 의해서 초기 여드름이 유발되는데, 특히 테스토스테론(testosterone)이 가장 중요한 호르몬으로 인지되며, 이 호르몬은 피지선을 자극하여 피지의 생성을 증가시킨다. 피지는 초기 분비 시 트리글리세롤로 구성되나 점차 프로피오니박테리움 아크네스의 세포외 효소(extracellular enzyme) 중 하나인 리파아제에 의해서 유리지방산과 글리세롤로 분해된다. 피부의 유리지방산 중 이 세균에 의한 것이 95%를 차지하고 여드름의 씨앗인 미세면포의 형성과 염증반응을 유도한다. 프로피오니박테리움 아크네스의 세포외 효소에는 리파아제, 프로테아제(protease), 하이아루로니다제(hyaluronidase) 등이 대표적인 것으로 이것은 여드름의 진행에 있어서 중요한 영향을 미친다. 둘째는 모공의 폐쇄이다. 프로피오니박테리움 아크네스의 작용으로 생성되는 유리지방산과 호르몬의 영향을 받은 피부의 과각화와 피지의 과잉분비로 인해 누두부가 폐쇄되는데, 이로 인해서 혐기성세균인 프로피오니박테리움 아크네스의 증식이 용이하게 된다. 셋째는 혐기성 세균인 프로피오니박테리움 아크네스의 수의 증가이다. 피지성분이 하얀 덩어리 또는 멜라닌의 접착된 흑색 덩어리로 축적되면 프로피오니박테리움 아크네스가 증가하게 된다. 상기 3가지가 여드름을 유발하는 가장 큰 요인이지만, 이외에도 스트레스로 인한 신경 단백체의 작용, 유전적 요인, 화장품, 과각화를 유발하는 열과 습기, 자외선 등의 요인도 여드름 발생과 관련이 깊다.The cause of acne can be divided into three major categories. First, sebaceous glands are overproduced. Testosterone is recognized as the most important hormone, and this hormone stimulates sebaceous glands and increases the production of sebum. Sebum is composed of triglycerol at the initial secretion but gradually decomposed into free fatty acid and glycerol by lipase which is one of the extracellular enzymes of Propionibacterium acnes. Of the free fatty acids in the skin, 95% of these bacteria are responsible for the formation of microfilaments, which are the seeds of acne, and inflammatory responses. The extracellular enzymes of Propionibacterium acnes are typified by lipase, protease, hyaluronidase, etc. This has an important influence on the progression of acne. The second is the closure of pores. Due to the exaggeration of the skin and excessive secretion of sebum, which are influenced by the free fatty acids and hormones produced by the action of Propionibacterium acnes, the pustule is closed. As a result, the proliferation of the anaerobic bacterium, Propionibacterium acnes, do. The third is the increase in the number of anaerobic bacterium, Propionibacterium acnes. When the sebum component is accumulated in a white lump or a melted black lump of melanin, Propionibacterium acnes is increased. Although these three factors are the biggest factors causing acne, other factors such as the action of neuroproteins due to stress, genetic factors, cosmetics, heat, moisture and ultraviolet rays which cause extinction are also related to the occurrence of acne.
한편, 이러한 여드름의 치료제는 병변에 직접 시행하는 국소 치료제와 약제를 복용하는 전신 치료제로 나누는데 국소 또는 전신 치료제들은 여드름의 형태와 각 단계에 따라 단독으로 또는 복합적으로 사용된다. 국소 치료제로는 합성비타민 A 연고, 벤조일 퍼옥사이드(benzoyl peroxide), 항생제 연고, 스테로이드 연고, 아젤라익산(azelaic acid) 등이 있고, 전신 치료제로는 경구 항생제, 호르몬제, 합성비타민 A 제제 등이 있다.In the meantime, the treatment of acne is divided into a topical treatment directly applied to the lesion and a systemic treatment taking the drug. Local or systemic treatments are used alone or in combination with each other depending on the type of acne and each step. Examples of topical treatments include synthetic vitamin A ointment, benzoyl peroxide, antibiotic ointment, steroid ointment, and azelaic acid, and systemic antibiotics, hormones, and synthetic vitamin A agents .
또한, 최근 들어 이러한 여드름을 해결해 주는 화장류가 인기를 끌고 있다. 그러나 이러한 화장류에 사용되는 살리실산(salicylic acid), 트리클로산(triclosan), 레틴올(retinol), 니신(nicin) 등과 같은 물질은 원료 자체는 항균효과가 우수하지만, 화장료 제형에서의 배합 제한 및 효과적 적용이 어렵다는 단점이 있다.In recent years, cosmetic products that solve such acne have become popular. However, materials such as salicylic acid, triclosan, retinol, and nicin used in such cosmetic compositions are excellent in antimicrobial effect on raw materials themselves, but they are limited in formulation and effectively applied in cosmetic formulations This is a disadvantage.
따라서, 여드름 피부에 있어서 인체에 안정하면서도 장기적으로 사용이 가능하며 효과가 우수한 제품의 개발 필요성이 꾸준히 대두되고 있으며 치료약에 비해 정상 피부의 손상이 적은 천연 추출물의 개발에 관심이 고조되고 있는 실정이다.Therefore, there is a constant need for the development of a product that can be used in a long-term and stable manner for human acne skin, and there is a growing interest in the development of a natural extract having less skin damage than a therapeutic agent.
본 발명은 목적은 생강 추출물, 양제근 추출물, 녹차 추출물 및 달맞이꽃씨 추출물로 이루어진 복합생약추출물을 유효성분으로 함유하는 여드름 예방 또는 치료용 화장료 조성물을 제공하는 데에 있다.It is an object of the present invention to provide a cosmetic composition for preventing or treating acne, which contains, as an active ingredient, a complex herbal medicine extract comprising ginger extract, root extract, green tea extract and evening primrose seed extract.
본 발명의 다른 목적은 생강 추출물, 양제근 추출물, 녹차 추출물 및 달맞이꽃씨 추출물로 이루어진 복합생약추출물을 유효성분으로 함유하는 여드름 예방 또는 치료용 약학 조성물을 제공하는 데에 있다.Another object of the present invention is to provide a pharmaceutical composition for preventing or treating acne, which contains, as an active ingredient, a complex herbal medicine extract comprising ginger extract, root extract, green tea extract and evening primrose seed extract.
본 발명의 또 다른 목적은 생강 추출물, 양제근 추출물, 녹차 추출물 및 달맞이꽃씨 추출물로 이루어진 복합생약추출물을 유효성분으로 함유하는 여드름 예방 또는 개선용 건강식품 조성물을 제공하는 데에 있다.Another object of the present invention is to provide a health food composition for prevention or improvement of acne which contains, as an active ingredient, a complex herbal medicine extract comprising ginger extract, root extract, green tea extract and evening primrose seed extract.
상기 목적을 달성하기 위하여, 본 발명은 생강 추출물, 양제근 추출물, 녹차 추출물 및 달맞이꽃씨 추출물로 이루어진 복합생약추출물을 유효성분으로 함유하는 여드름 예방 또는 치료용 화장료 조성물을 제공한다.In order to achieve the above object, the present invention provides a cosmetic composition for preventing or treating acne, which contains, as an active ingredient, a complex herbal medicine extract comprising ginger extract, root extract, green tea extract and evening primrose seed extract.
또한, 본 발명은 생강 추출물, 양제근 추출물, 녹차 추출물 및 달맞이꽃씨 추출물로 이루어진 복합생약추출물을 유효성분으로 함유하는 여드름 예방 또는 치료용 약학 조성물을 제공한다.In addition, the present invention provides a pharmaceutical composition for preventing or treating acne, which contains, as an active ingredient, a complex herbal medicine extract comprising ginger extract, root extract, green tea extract and evening primrose seed extract.
또한, 본 발명은 생강 추출물, 양제근 추출물, 녹차 추출물 및 달맞이꽃씨 추출물로 이루어진 복합생약추출물을 유효성분으로 함유하는 여드름 예방 또는 개선용 건강식품 조성물을 제공한다.In addition, the present invention provides a health food composition for preventing or improving acne, which contains, as an active ingredient, a complex herbal medicine extract comprising ginger extract, root extract, green tea extract and evening primrose seed extract.
본 발명은 복합생약추출물을 유효성분으로 함유하는 여드름 예방 및 치료용 화장료 조성물에 관한 것으로, 생강 추출물, 양제근 추출물, 녹차 추출물 및 달맞이꽃씨 추출물의 성분들을 동시에 함유하는 복합 추출물은 피지 생성 억제, 피지 분비 촉진, 과산화지질 생성 억제, 항산화 효과, 항균 효과, 염증성 사이토카인 억제 및 히스타민 분비 억제 효과가 있는 것을 확인하였다.The present invention relates to a cosmetic composition for prevention and treatment of acne, which comprises a complex herbal medicine extract as an active ingredient, and a complex extract containing components of ginger extract, soy sauce root extract, green tea extract and evening primrose seed extract simultaneously inhibits sebum production, Inhibition of lipid peroxidation, antioxidant effect, antimicrobial effect, inflammatory cytokine inhibition and inhibition of histamine secretion.
또한, 본 발명의 복합생약추출물은 여드름 예방 또는 치료용 약학 조성물, 여드름 예방 또는 개선용 건강식품 조성물로 활용될 수 있다.In addition, the herbal extract of the present invention can be used as a pharmaceutical composition for preventing or treating acne and a health food composition for preventing or improving acne.
본 발명자들은 상기 문제점을 고려하여, 여드름의 억제 또는 완화 효과가 뛰어나고 장시간 사용해도 피부에 안전성이 우수한 화장품을 개발하고자 연구한 결과, 생강 추출물(zingiber officinale (ginger) root extract), 양제근 추출물(rumex crispus root extract), 녹차 추출물(camellia sinensis leaf extract) 및 달맞이꽃씨 추출물(oenothera biennis (evening primrose) seed extract)의 성분들을 동시에 함유하는 복합 추출물에서 여드름 억제 또는 완화 효과가 상승되고 안전성이 뛰어남을 확인함으로써 본 발명을 완성하였다.In view of the above problems, the inventors of the present invention have conducted studies to develop cosmetics having excellent suppression or alleviating effect of acne and excellent safety for skin even after prolonged use. As a result, it has been found that ginger extract (zingiber officinale (ginger) root extract), rumex crispus root extract, camellia sinensis leaf extract, and oenothera biennis (evening primrose) seed extract were found to be effective in improving acne suppression or mitigation efficacy and safety. Thereby completing the invention.
본 발명에서 사용된 용어 “예방”은 복합생약추출물에 의해 여드름 질환을 억제시키거나 발병을 지연시키는 모든 행위를 의미한다.The term " prophylactic " as used herein refers to any action that inhibits or delay the onset of acne disease by the herbal extract of the complex.
본 발명에서 사용된 용어 “치료”는 복합생약추출물에 의해 여드름 질환의 증세가 호전되거나 이롭게 변경하는 모든 행위를 의미한다.As used herein, the term " treatment " means any action that improves or alleviates symptoms of acne disease by the herbal extract of the complex.
본 발명에서 사용된 용어 “복합생약추출물”은 생강 추출물, 양제근 추출물, 녹차 추출물 및 달맞이꽃씨 추출물의 성분들을 동시에 함유하는 추출물을 의미한다.The term " complex herbal medicine extract " used in the present invention means an extract which simultaneously contains components of ginger extract, root extract, green tea extract and evening primrose seed extract.
생강은 외떡잎식물 생강목 생강과의 여러해살이풀로 뿌리를 사용할 수 있으며 억균 작용 등의 효과가 있다. 또한, 혈액순환을 자극하고 촉진시키는 성분을 함유하여 피부 회복 및 흉터 제거 효과를 가지는 것으로 알려져 있다.Ginger is a perennial plant with ginger, ginger, ginger, and can be used as roots and has an effect such as yeast. It is also known to have skin recovery and scar removal effects by containing ingredients that stimulate and promote blood circulation.
양제근은 소루쟁이, 솔쟁이, 송구지 등으로 불리며, 한여름이면 줄기가 다 말라 버렸다가 선선하면 다시 자라나는 여뀌과의 다년생 식물이다. 어린 잎은 나물로 먹기도 하며, 백선, 무좀, 습진 등에 효과가 있다. 예로부터 민간에서는 개선, 옴, 피부암 등의 피부병에 사용하였으며, 방광염, 대장염 등에도 달여서 사용했다고 알려진다. 가을에 뿌리를 캐서 둥글게 말린 것을 양제근이라고 한다. 양제근 추출물은 엘라스타아제, 히알루로니다아제의 분비 및 작용 억제 효과가 매우 우수하며, IL-8(interleukin-8) 등과 같은 염증 매개 사이토카인의 분비 억제를 통한 우수한 항염증 효과를 나타내는 것으로 알려져 있다.It is called perennial plant, which is called perennial plant. Young leaves can be eaten as herbs, and they are effective for white pine, athlete's foot, eczema. In the past, it has been used in the private sector for skin diseases such as improvement, omnis, and skin cancer, and it has been known to be used for cystitis and colitis. It is said to be rooted in the fall and dried round. The extract of Yangyangjang is highly effective in inhibiting the secretion and action of hyaluronidase and is known to exhibit excellent antiinflammatory effects through inhibition of the secretion of inflammatory mediators such as IL-8 (interleukin-8) .
녹차의 카테킨은 폴리페놀의 일종으로 탄닌이라고도 한다. 이 성분은 항산화 작용으로 인한 피부 미용 및 노화 예방 효과가 있으며 활성 산소를 제거하고 기미나 주근깨 형성을 억제하며, 색소 침착 예방, 피부 수렴 작용, 모공 수축 작용을 가진다.Catechin in green tea is a type of polyphenol, also known as tannin. This ingredient has antioxidant effect to prevent skin beauty and aging, it removes active oxygen, inhibits spots and freckles, has pigmentation prevention, skin convergence, and pore contraction.
달맞이꽃은 바늘꽃과의 두해살이 식물로 리놀산과 γ-리놀렌산 및 올레인산 등의 불포화 지방산으로 구성되어 있으며, 한방에서는 월견초라는 약재로 쓰이고 있으며, 감기로 열이 높고 인후염이 있을 때 사용하며, 종자는 월견자라고 하여 고지혈증에도 사용되며, 피부 안정성 및 아토피 증상 개선에 효과가 있는 것으로 알려 있다.Evening primrose is a biennial plant of Pinus densiflora and is composed of linoleic acid, unsaturated fatty acids such as γ-linolenic acid and oleic acid, and is used as a medicinal product in the oriental medicine. It is used when the fever is high with fever and sore throat. It is also used for hyperlipidemia, and it is known that it is effective for improving skin stability and atopic symptoms.
본 발명에서 사용된 용어 “유효성분”이란 내재된 약리작용에 의해 그 의약품의 효능 및/또는 효과를 직접 또는 간접적으로 발현한다고 기대되는 물질 또는 물질군(약리학적 활성성분 등이 밝혀지지 않은 생약 등을 포함한다)으로서 주성분으로 포함하는 것을 의미한다. The term " effective ingredient " as used herein refers to a substance or a group of substances expected to directly or indirectly express the efficacy and / or efficacy of the drug by the inherent pharmacological action (pharmacologically active ingredients, As a main component.
본 발명은 생강 추출물, 양제근 추출물, 녹차 추출물 및 달맞이꽃씨 추출물로 이루어진 복합생약추출물을 유효성분으로 함유하는 여드름 예방 또는 치료용 화장료 조성물을 제공한다.The present invention provides a cosmetic composition for preventing or treating acne, which contains, as an active ingredient, a complex herbal medicine extract comprising a ginger extract, a root extract, a green tea extract and an evening primrose seed extract.
바람직하게는, 상기 화장료 조성물에서 상기 생강 추출물, 양제근 추출물, 녹차 추출물 및 달맞이꽃씨 추출물의 중량비는 1:1:1:1일 수 있으나, 이에 제한되는 것은 아님을 명시한다. Preferably, the weight ratio of the ginger extract, root extract, green tea extract and evening primrose seed extract in the cosmetic composition may be 1: 1: 1: 1, but is not limited thereto.
바람직하게는, 상기 생강 추출물, 양제근 추출물 및 녹차 추출물은 증류수를 사용하여 추출할 수 있으나, 이에 제한되는 것은 아님을 명시한다.Preferably, the ginger extract, root extract and green tea extract may be extracted using, but not limited to, distilled water.
바람직하게는, 상기 달맞이꽃씨 추출물은 물, C1 내지 C4의 알코올 또는 이들의 혼합물로 이루어진 군으로 선택된 용매를 사용하여 추출할 수 있으나, 이에 제한되는 것은 아님을 명시한다.Preferably, the Evening Primrose Seed Extract may be extracted using, but not limited to, solvents selected from the group consisting of water, C1 to C4 alcohols, or mixtures thereof.
바람직하게는, 상기 복합생약추출물은 프로피오니박테리움 아크네스(Propionibacterium acnes) 및 스태필로코커스 에피더미스(Staphylococcus epidermidis)에 대해 항균 활성을 가질 수 있다.Preferably, the complex herbal extract may have antibacterial activity against Propionibacterium acnes and Staphylococcus epidermidis.
본 발명의 조성물이 화장료 조성물인 경우, 상기 화장료 조성물은 상기 유효성분 외에 안정화제, 용해화제, 비타민, 안료 및 향료와 같은 통상적인 보조제, 그리고 담체를 포함할 수 있다. 또한 상기 화장료 조성물은 그 효과를 증진시키기 위해 피부 흡수 촉진제를 추가로 포함할 수 있다.When the composition of the present invention is a cosmetic composition, the cosmetic composition may contain conventional additives such as stabilizers, solubilizers, vitamins, pigments and fragrances, and carriers in addition to the active ingredients. In addition, the cosmetic composition may further include a skin absorption promoter to promote its effect.
상기 화장료 조성물의 제형은 당업계에서 통상적으로 제조되는 어떠한 제형으로도 제조될 수 있으며, 예를 들어, 화장료 조성물은 화장수, 유액, 스킨, 토너, 로션, 에센스, 선 스크린, 크림, 메이크업 베이스, 파운데이션, 파우더, 팩, 젤, 샴푸, 린스, 스프레이, 메이크업 제거제 및 세정제등으로 제형화 될 수 있으나, 이에 한정되는 것은 아님을 명시한다.For example, the cosmetic composition may be in the form of a lotion, a lotion, a skin, a toner, a lotion, an essence, a sunscreen, a cream, a makeup base, a foundation, , Powders, packs, gels, shampoos, rinses, sprays, make-up removers and detergents, but is not limited thereto.
상기 제형이 페이스트, 크림 또는 겔인 경우에는 담체 성분으로서 동물성유, 식물성유, 왁스, 파라핀, 전분, 트라칸트, 셀룰로오스 유도체, 폴리에틸렌 글리콜, 실리콘, 벤토나이트, 실리카, 탈크 또는 산화아연 등이 이용될 수 있다.When the formulation is a paste, cream or gel, an animal oil, a vegetable oil, a wax, a paraffin, a starch, a tracer, a cellulose derivative, polyethylene glycol, silicone, bentonite, silica, talc or zinc oxide may be used as a carrier component .
상기 제형이 파우더 또는 스프레이인 경우에는 담체 성분으로서 락토스, 탈크, 실리카, 알루미늄 히드록시드, 칼슘 실리케이트 또는 폴리아미드 파우더가 이용될 수 있고, 특히 스프레이인 경우에는 추가적으로 클로로플루오로히드로카본, 프로판/부탄 또는 디메틸 에테르와 같은 추진체를 포함할 수 있다.When the formulation is a powder or a spray, lactose, talc, silica, aluminum hydroxide, calcium silicate or polyamide powder may be used as a carrier component. In the case of a spray, in particular, chlorofluorohydrocarbons, propane / Or propellants such as dimethyl ether.
상기 제형이 용액 또는 유탁액인 경우에는 담체 성분으로서 용매, 용해화제 또는 유탁화제가 이용되고, 예컨대 물, 에탄올, 이소프로판올, 에틸 카보네이트, 에틸 아세테이트, 벤질 알코올, 벤질 벤조에이트, 프로필렌 글리콜, 1,3-부틸글리콜 오일, 글리세롤 지방족 에스테르, 폴리에틸렌 글리콜 또는 소르비탄의 지방산 에스테르가 있다.When the formulation is a solution or an emulsion, a solvent, a solubilizing agent or an emulsifying agent is used as a carrier component, and examples thereof include water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, - butyl glycol oil, glycerol aliphatic ester, polyethylene glycol or fatty acid esters of sorbitan.
상기 제형이 현탁액인 경우에는 담체 성분으로서 물, 에탄올 또는 프로필렌 글리콜과 같은 액상의 희석제, 에톡실화 이소스테아릴 알코올, 폴리옥시에틸렌 소르비톨 에스테르 및 폴리옥시에틸렌 소르비탄 에스테르와 같은 현탁제, 미소결정성 셀룰로오스, 알루미늄 메타히드록시드, 벤토나이트, 아가 또는 트라칸트 등이 이용될 수 있다.When the formulation is a suspension, a carrier such as water, a liquid diluent such as ethanol or propylene glycol, a suspension such as ethoxylated isostearyl alcohol, polyoxyethylene sorbitol ester and polyoxyethylene sorbitan ester, a microcrystalline cellulose , Aluminum metahydroxide, bentonite, agar or tracant, etc. may be used.
본 발명은 생강 추출물, 양제근 추출물, 녹차 추출물 및 달맞이꽃씨 추출물로 이루어진 복합생약추출물을 유효성분으로 함유하는 여드름 예방 또는 치료용 약학 조성물을 제공한다.The present invention provides a pharmaceutical composition for preventing or treating acne, which contains, as an active ingredient, a complex herbal medicine extract comprising a ginger extract, a root extract, a green tea extract and an evening primrose seed extract.
본 발명의 조성물이 약학 조성물인 경우, 크림, 젤, 패취, 분무제, 연고제, 경고제, 로션제, 리니멘트제, 파스타제 및 카타플라스마제 등으로 제형화 될 수 있다. 한편, 상기 약학 조성물은 상기 유효성분 이외에 약제학적으로 허용되는 담체를 포함할 수 있는데, 이러한 약제학적으로 허용되는 담체는 약품 제제 시에 통상적으로 이용되는 것으로서, 락토스, 덱스트로스, 수크로스, 솔비톨, 만니톨, 전분, 아카시아 고무, 인산 칼슘, 알기네이트, 젤라틴, 규산 칼슘, 미세결정성 셀룰로스, 폴리비닐피롤리돈, 셀룰로스, 물, 시럽, 메틸 셀룰로스, 메틸히드록시벤조에이트, 프로필히드록시벤조에이트, 활석, 스테아르산 마그네슘, 미네랄 오일 등을 포함할 수 있으나, 이에 한정되는 것은 아니다. 또한, 상기 약학 조성물은 첨가제로서 윤활제, 습윤제, 감미제, 향미제, 유화제, 현탁제, 보존제 등을 추가로 포함할 수 있다.When the composition of the present invention is a pharmaceutical composition, it may be formulated into a cream, a gel, a patch, a spray, an ointment, a warning agent, a lotion, a liniment, a pasta, and a cataplasma. In addition, the pharmaceutical composition may contain a pharmaceutically acceptable carrier in addition to the above-mentioned effective ingredient. Such pharmaceutically acceptable carriers are those conventionally used in pharmaceutical preparations, and include lactose, dextrose, sucrose, sorbitol, But are not limited to, mannitol, starch, acacia, calcium phosphate, alginate, gelatin, calcium silicate, microcrystalline cellulose, polyvinylpyrrolidone, cellulose, water, syrup, methylcellulose, methylhydroxybenzoate, Talc, magnesium stearate, mineral oil, and the like, but is not limited thereto. In addition, the pharmaceutical composition may further include a lubricant, a wetting agent, a sweetener, a flavoring agent, an emulsifying agent, a suspending agent, a preservative, etc. as an additive.
상기 약학 조성물은 증상 정도에 따라 투여 방법이 결정되는데, 통상적으로는 국소 투여 방식이 바람직하다. 또한, 상기 약학 조성물 중 유효성분의 투여량은 투여경로, 질병의 정도, 환자의 나이, 성별, 체중 등에 따라 달라질 수 있으며, 일일 1회 내지 수회 투여할 수 있다.The method of administration of the pharmaceutical composition is determined depending on the severity of symptoms, and local administration is generally preferred. The dosage of the active ingredient in the pharmaceutical composition may vary depending on the route of administration, the severity of the disease, the age, sex, and weight of the patient, and may be administered once to several times per day.
생강 추출물, 양제근 추출물, 녹차 추출물 및 달맞이꽃씨 추출물로 이루어진 복합생약추출물을 유효성분으로 함유하는 여드름 예방 또는 개선용 건강식품 조성물을 제공한다.The present invention provides a health food composition for preventing or ameliorating acne, which contains, as an active ingredient, a complex herbal medicine extract comprising a ginger extract, a root extract, a green tea extract and an evening primrose seed extract.
상기 건강식품 조성물은 분말, 과립, 정제, 캡슐, 시럽 또는 음료의 형태로 제공될 수 있으며, 상기 건강식품 조성물은 상기 유효성분 이외에 다른 식품 또는 식품 첨가물과 함께 사용되고, 통상적인 방법에 따라 적절하게 사용될 수 있다. 유효성분의 혼합양은 그의 사용 목적 예를 들어 예방, 건강 또는 치료적 처치에 따라 적합하게 결정될 수 있다.The health food composition may be provided in the form of powder, granules, tablets, capsules, syrups or beverages. The health food composition may be used in combination with other food or food additives other than the active ingredient, . The amount of the active ingredient to be mixed can be suitably determined according to its use purpose, for example, prevention, health or therapeutic treatment.
상기 건강식품 조성물에 함유된 상기 유효성분의 유효용량은 상기 약학 조성물의 유효용량에 준해서 사용할 수 있으나, 건강 및 위생을 목적으로 하거나 또는 건강 조절을 목적으로 하는 장기간의 섭취의 경우에는 상기 범위 이하일 수 있으며, 유효성분은 안전성 면에서 아무런 문제가 없기 때문에 상기 범위 이상의 양으로도 사용될 수 있음은 확실하다.The effective dose of the active ingredient contained in the health food composition may be used in accordance with the effective dose of the pharmaceutical composition. However, in the case of long-term consumption intended for health and hygiene purposes or health control purposes, And it is clear that the active ingredient can be used in an amount exceeding the above range since there is no problem in terms of safety.
상기 건강식품의 종류에는 특별한 제한이 없고, 예로는 육류, 소세지, 빵, 쵸코렛, 캔디류, 스넥류, 과자류, 피자, 라면, 기타 면류, 껌류, 아이스크림류를 포함한 낙농제품, 각종 스프, 음료수, 차, 드링크제, 알콜 음료 및 비타민 복합제 등을 들 수 있다.There is no particular limitation on the type of the health food, and examples thereof include meat, sausage, bread, chocolate, candy, snack, confectionery, pizza, ramen, other noodles, gums, dairy products including ice cream, Drinks, alcoholic beverages and vitamin complexes.
이하에서는 실시예를 통하여 본 발명을 더욱 상세히 설명하고자 한다. 이들 실시예는 오로지 본 발명을 보다 구체적으로 설명하기 위한 것으로, 본 발명의 요지에 따라 본 발명의 범위가 이들 실시예에 의해 제한되지 않는다는 것은 당업계에서 통상의 지식을 가진 자에 있어서 자명할 것이다.Hereinafter, the present invention will be described in more detail with reference to Examples. It is to be understood by those skilled in the art that these embodiments are only for describing the present invention in more detail and that the scope of the present invention is not limited by these embodiments in accordance with the gist of the present invention .
실시예Example 1 : 추출물 제조 1: Preparation of extract
1-1. 생강 추출물 1-1. Ginger extract
생강과 증류수의 비율을 1:4로 혼합하여 분쇄한 후, 24시간 상온에서 추출하고 필터페이퍼(Whatman #7)를 이용하여 액상으로 분리하였다.The mixture of ginger and distilled water was mixed at a ratio of 1: 4, followed by pulverization, extraction at room temperature for 24 hours, and separation into a liquid phase using a filter paper (Whatman # 7).
1-2. 양제근 추출물 1-2. Yangjungguk extract
양제근과 증류수의 비율을 1:8로 혼합하여, 70℃ 이상의 온도에서 2시간 동안 가온하여 추출하고 필터페이퍼(Whatman #7)를 이용하여 액상으로 분리하였다.The mixture was mixed at a ratio of 1: 8, and the mixture was heated at 70 ° C or higher for 2 hours and extracted into a liquid phase using a filter paper (Whatman # 7).
1-3. 녹차 추출물1-3. Green tea extract
녹차잎과 증류수의 비율을 1:8로 혼합하여, 70℃ 이상의 온도에서 2시간 동안 가온하여 추출하고 필터페이퍼(Whatman #7)를 이용하여 액상으로 분리하였다.The green tea leaves and distilled water were mixed at a ratio of 1: 8, and the mixture was heated at 70 ° C or higher for 2 hours and extracted into liquid phase using filter paper (Whatman # 7).
1-4. 달맞이꽃씨 추출물1-4. Evening Primrose Seed Extract
달?Ю牽?씨와 60% 에탄올의 비율을 1:4로 혼합하여 분쇄한 후, 상온에서 2일간 추출한 후 필터페이퍼(Whatman #7)를 이용하여 액상으로 분리하고, 분리된 액상을 감압증류하여 에탄올을 제거하였다.The mixture was pulverized at a ratio of 1: 4 of 60% ethanol and then extracted at room temperature for 2 days. The filtrate was separated into liquid phase using a filter paper (Whatman # 7), and the separated liquid phase was distilled under reduced pressure To remove ethanol.
실시예Example 2: 추출물의 항균 활성 측정 2: Measurement of antibacterial activity of extract
추출물의 항균활성은 디스크 확산법(Paper disk diffusion method)을 이용하여 측정하였다.The antimicrobial activity of the extracts was measured using a paper disk diffusion method.
2-1. 추출물에 의한 프로피오니박테리움 아크네스 항균 효과2-1. Antibacterial effect of propionibacterium acnes on extracts
GAM 배지(GAM broth)에 프로피오니박테리움 아크네스(Propionibacterium acnes, KCTC3314 ATCC6919) 균을 37℃에서 48시간 동안 혐기성 조건으로 배양한 다음, 배양액 0.1 ml를 1.5%의 한천(agar)을 첨가한 한천 플레이트에 골고루 도말한다. 도말된 한천 플레이트에 추출물(생강 추출물, 양제근 추출물, 녹차 추출물, 달맞이꽃씨 추출물, 복합 추출물) 0.05 ml를 흡수시킨 페이퍼 디스크(Paper disk, 직경 8 mm)를 올려놓고 3일간 혐기성 조건으로 배양하여 디스크 주위의 억제환(inhibition zone)의 크기를 측정하였으며, 이의 결과를 하기 표 1에 나타내었다.Propionibacterium acnes (KCTC3314 ATCC 6919) was cultured in GAM broth at 37 ° C for 48 hours under anaerobic conditions. Then, 0.1 ml of the culture was added to 1.5 ml of agar containing agar Plate evenly on the plate. A paper disk (diameter: 8 mm) in which 0.05 ml of extracts (ginger extract, Yangjaedong extract, green tea extract, evening primrose extract, compound extract) was absorbed was placed on the agar agar plate and incubated for 3 days under anaerobic conditions. The inhibition zones of the inhibition zone were measured and the results are shown in Table 1 below.
그 결과, 표 1을 참조하여 보면, 생강 추출물, 양제근 추출물, 녹차 추출물 및 달맞이꽃씨 추출물 각각을 흡수시킨 페이퍼 디스크의 억제환 크기는 1 mm, 0.5 mm, 1.5 mm, 0.5 mm였으며, 복합 추출물을 흡수시킨 페이퍼 디스크의 억제환 크기는 6 mm로 프로피오니박테리움 아크네스 균의 활성을 더욱 효과적으로 억제하는 것을 확인하였다.As a result, as shown in Table 1, the suppression rings of the ginger extract, the green tea extract, the green tea extract and the evening primrose seed extract were 1 mm, 0.5 mm, 1.5 mm and 0.5 mm, respectively, It was confirmed that the inhibition ring size of the paper disk was 6 mm, which more effectively inhibited the activity of P. bacterium acnes.
2-2. 추출물에 의한 스태필로코커스 에피더미스 항균 효과2-2. Antibacterial effect of staphylococcus epidermis by extract
영양 배지(nutrient broth)에 스태필로코커스 에피더미스(Staphylococcus epidermidis, KCTC1917) 균을 37℃에서 24시간 동안 호기성 조건으로 배양한 다음, 배양액 0.1 ml를 1.5%의 한천을 첨가한 한천 플레이트에 골고루 도말한다. 도말된 한천 플레이트에 추출물(생강 추출물, 양제근 추출물, 녹차 추출물, 달맞이꽃씨 추출물, 복합 추출물) 0.05 ml를 흡수시킨 페이퍼 디스크(Paper disk, 직경 8 mm)를 올려 놓고 2일간 호기성 조건으로 배양하여 디스크 주위의 억제환(inhibition zone)의 크기를 측정하였으며, 이의 결과를 하기 표 1에 나타내었다.Staphylococcus epidermidis (KCTC1917) was cultured in an aerobic condition at 37 ° C for 24 hours in a nutrient broth. Then, 0.1 ml of the culture was added to an agar plate to which 1.5% of agar was added, do. A paper disk (diameter: 8 mm) in which 0.05 ml of extracts (ginger extract, two-legged root extract, green tea extract, evening primrose extract, compound extract) was absorbed was placed on the agar agar plate and cultured under aerobic conditions for 2 days. The inhibition zones of the inhibition zone were measured and the results are shown in Table 1 below.
그 결과, 표 1을 참조하여 보면, 생강 추출물, 양제근 추출물, 녹차 추출물 및 달맞이꽃씨 추출물 각각을 흡수시킨 페이퍼 디스크의 억제환 크기는 1.5 mm, 0.5 mm, 2 mm, 0.5 mm였으며, 복합 추출물을 흡수시킨 페이퍼 디스크의 억제환 크기는 7 mm로 스태필로코커스 에피더미스 균의 활성을 더욱 효과적으로 억제하는 것을 확인하였다.As a result, as shown in Table 1, the inhibitory ring size of the paper disk absorbed with each of the ginger extract, the root extract, the green tea extract and the evening primrose seed extract was 1.5 mm, 0.5 mm, 2 mm and 0.5 mm, The inhibition ring size of the paper disk was 7 mm, which confirmed that the activity of Staphylococcus epidermis was more effectively inhibited.
extract
*복합추출물 : 생강 추출물, 양제근 추출물, 녹차 추출물, 달맞이꽃씨 추출물을 동일 비율로 혼합한 추출물.* Compound Extract: Extract of Ginger Extract, Soybean Curd Extract, Green Tea Extract, Evening Primrose Seed Extract mixed at the same ratio.
*저지대의 폭 계산법 : 저지대의 폭=(시료디스크와 저지대의 전체 지름 - 시료디스크 지름)/2* Calculating the width of the low-lying zone: width of the low-lying zone = (total diameter of sample disc and low-sample disc diameter) / 2
실시예Example 3 : 복합추출물을 함유한 3: Containing complex extracts 에멀젼emulsion 로션 제조 Lotion manufacturing
하기 표 2에 나타난 바와 같은 조성비로 실시예 1에서 수득한 추출물과 유성성분, 수성성분, 계면활성제 등과 함께 혼합기에서 유화시키고 탈기, 여과, 냉각시킴으로서 에멀젼 로션을 제조하였다. 여기에 첨가제로 방부제 및 향료를 첨가하였다. Emulsified lotion was prepared by emulsifying the extract obtained in Example 1 with an oily component, an aqueous component and a surfactant in a mixer and degassing, filtering and cooling at a composition ratio shown in Table 2 below. Preservatives and flavors were added thereto as an additive.
실시예Example 4 : 복합 추출물을 함유하는 4: Compounds containing complex extracts 에멀젼emulsion 로션의 여드름 억제 효과 Effect of Lotion on Acne
상기 실시예 3에서 제조된 복합 추출물을 함유하는 에멀젼 로션의 여드름 억제 효과를 확인하기 위해, 에멀젼 로션을 30일 동안 1일, 1회 여드름 피부에 도포하였다. 그 결과, 15일째에 여드름의 염증이 약 50% 감소하였으며, 30일째에 약 90% 감소하는 것을 확인하였다. To confirm the effect of suppressing the acne of the emulsion lotion containing the complex extract prepared in Example 3, the emulsion lotion was applied to the acne skin once a day for 30 days. As a result, it was confirmed that acne inflammation was reduced by about 50% on the 15th day and decreased by about 90% on the 30th day.
실시예Example 5 : 복합추출물을 함유한 5: Containing complex extracts 스킨skin 제조 Produce
하기 표 3에 나타난 바와 같은 조성비로 실시예 1에서 수득한 추출물과 유성성분, 수성성분, 계면활성제 등과 함께 혼합기에서 유화시키고 탈기, 여과, 냉각시킴으로서 스킨을 제조하였다. 여기에 첨가제로 방부제 및 향료를 첨가하였다. The extracts obtained in Example 1 were emulsified in a mixer together with an oily component, an aqueous component and a surfactant in a composition ratio as shown in Table 3 below, followed by degassing, filtering and cooling to prepare skins. Preservatives and flavors were added thereto as an additive.
실시예Example 6 : 복합추출물을 함유한 세안제 제조 6: Manufacture of cleanser containing complex extract
하기 표 4에 나타난 바와 같은 조성비로 실시예 1에서 수득한 추출물과 세안제 베이스를 함께 혼합기에서 유화시키고 탈기, 여과, 냉각시킴으로서 세안제를 제조하였다. 여기에 첨가제로 방부제 및 향료를 첨가하였다. The extracts obtained in Example 1 and the cleanser base were emulsified together in a mixer and degassed, filtered and cooled to prepare a cleanser at the composition ratios shown in Table 4 below. Preservatives and flavors were added thereto as an additive.
이상으로 본 발명의 특정한 부분을 상세히 기술한 바, 당업계의 통상의 지식을 가진 자에게 있어서 이러한 구체적인 기술은 단지 바람직한 구현 예일 뿐이며, 이에 본 발명의 범위가 제한되는 것이 아닌 점은 명백하다. 따라서, 본 발명의 실질적인 범위는 첨부된 청구항과 그의 등가물에 의하여 정의된다고 할 것이다.While the present invention has been particularly shown and described with reference to exemplary embodiments thereof, it is clearly understood that the same is by way of illustration and example only and is not to be construed as limiting the scope of the invention. Accordingly, the actual scope of the present invention will be defined by the appended claims and their equivalents.
본 발명의 범위는 후술하는 특허청구범위에 의하여 나타내어지며, 특허청구범위의 의미 및 범위 그리고 그 균등 개념으로부터 도출되는 모든 변경 또는 변형된 형태가 본 발명의 범위에 포함되는 것으로 해석되어야 한다.The scope of the present invention is defined by the appended claims, and all changes or modifications derived from the meaning and scope of the claims and their equivalents should be construed as being included within the scope of the present invention.
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| KR102170850B1 (en) * | 2020-06-26 | 2020-11-02 | 박시헌 | A composition for treating acne or improving acne skin |
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| KR102170850B1 (en) * | 2020-06-26 | 2020-11-02 | 박시헌 | A composition for treating acne or improving acne skin |
| WO2021261971A1 (en) * | 2020-06-26 | 2021-12-30 | 박시헌 | Composition for acne treatment or skin improvement |
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