KR20170116009A

KR20170116009A - 전립선암의 진단을 위한 신규한 rna-바이오마커 시그니처

Info

Publication number: KR20170116009A
Application number: KR1020177018186A
Authority: KR
Inventors: 프리데만 혼; 요르그 해커뮐러; 사비나 크리스트; 크리스틴 라이케; 맨프레드 비르스; 미카엘 프로네르; 수잔 퍼셀
Original assignee: 프라운호퍼-게젤샤프트 추어 푀르더룽 데어 안게반텐 포르슝 에.파우.
Priority date: 2014-12-01
Filing date: 2015-12-01
Publication date: 2017-10-18
Also published as: WO2016087430A1; JP2018505656A; EP3227460B1; EP3227460A1; US20170362662A1; CA2969154A1; CN107223162A

Abstract

본 발명은 종양 세포에서 차별적으로 발현되는 전사체(바이오마커)의 확인 및 선택에 관한 것이다. 이들 바이오마커의 레벨의 구체적인 결정은 전립선암의 검진 및 진단에서 사용할 수 있다. 이들 바이오마커를 기반으로 하는 분석법의 임상적 적용은 현재의 표준 스크리닝 분석의 허위 양성의 수를 줄이는데 도움이 된다.

Description

전립선암의 진단을 위한 신규한 RNA-바이오마커 시그니처{NOVEL RNA-BIOMARKER SIGNATURE FOR DIAGNOSIS OF PROSTATE CANCER}

본 발명은 생물학 및 화학 분야에 속한다. 특히, 본 발명은 분자 생물학 분야에 속한다. 특히, 본 발명은 RNA 전사체의 분석에 관한 것이다. 특히, 본 발명은 전립선암을 진단하는 분야에 속한다.

전립선암은 남성에서 가장 빈번하게 진단되는 암이다. 2012년 연간 새롭게 진단된 전립선암 사례의 수는 미국에서는 대략 240,000 건, 유럽 연합에서는 360,000 건, 독일에서는 68,000 건인 것으로 보고되었다. 미국에서 전립선암 진단 및 전립선암으로 인한 사망 위험이 현재 각각 15.9%와 2.8%로 추산된다. 전립선암에 대한 광범위한 검진 및 전이성 질환 치료의 주요 발전에도 불구하고, 전립선암은 여전히 서구 세계에서 매년 250.000 명이 넘는 사망자가 발생하는 남성 암 사망의 두 번째로 흔한 원인이다.

현재 전립선 특이 항원(prostate-specific antigen, PSA) 혈청 농도의 검사 및 직장 수지 검사는 두 가지 주요 검진 방법이다. 비정상적인 결과를 보이는 환자는 일반적으로 전립선 생검을 시행하는 것이 좋다. 이는 그러나 중요한 결과를 초래한다. 많은 수의 거짓 양성(false positive)을 초래하는 PSA 검진의 특이성 결핍은 전세계적으로 수백만 명의 남성에게 매년 수행되는 불필요한 전립선 생검을 초래한다(과다 진단). 또한 생검을 받는 것은 감염성 합병증에 상당한 위험을 초래한다. 따라서, 전립선암 검진을 향상시키고 불필요하게 받는 많은 수의 전립선 생검을 피하기 위해 조기 전립선암 진단을 위한 더욱 민감하고 특이적인 진단 분석이 절실한 상황이다. 본 발명은 전립선암의 검진 및 진단을 위한 일련의 바이오마커를 제공함으로써 이러한 문제점을 해결한다.

종양 및 대조군 조직에서 차별적으로 발현된 전사체는 전립선암 환자 및 대조군의 64 개 샘플의 차세대 염기서열 분석에 의해 확인되었고, 각각 256 및 56 개 샘플의 마이크로어레이 및 qRT-PCR 분석에 의해 검증되었다. 본 발명은 지금까지는 전립선암의 진단에 사용하기에 적합한 것으로 밝혀지지 않은 RNA 바이오마커를 기술한다.

본 발명은 환자의 샘플에서 적어도 두 개의 핵산의 발현 수준을 분석하는 단계를 포함하는 전립선암의 진단 방법에 관한 것으로, 상기 적어도 두 개의 핵산은 적어도 두 그룹의 핵산에서 선택되고, 상기 그룹은,

그룹 1: 서열번호 1

그룹 2: 서열번호 4, 5, 6, 7, 8, 9 및 10으로 이루어진 군에서 선택되는 Ensembl 유전자 ID ENSG00000245750.3의 스플라이스 변이체

그룹 3: 서열번호 26, 27, 28 및 29로 이루어진 군에서 선택되는 Ensembl 유전자 ID ENSG00000255545.3의 스플라이스 변이체

그룹 4: 서열번호 3 및 11

그룹 5: 서열번호 12

그룹 6: 서열번호 24

그룹 7: 서열번호 36

그룹 8: 서열번호 38로 구성되고,

상기 적어도 두 개의 핵산의 발현 수준이 임계값보다 큰 경우, 상기 샘플은 전립선암 양성으로 지정된다.

본 발명은 또한 엄격한 조건 하에서 상기 그룹의 핵산과 혼성화하는 일련의 핵산에 관한 것이다.

본 발명은 또한 전립선암의 진단 방법의 용도에 관한 것이다.

본 발명은 또한 엄격한 조건 하에서 적어도 두 개의 핵산에 혼성화하는 적어도 두 개의 프라이머 또는 프로브를 포함하는 전립선암 진단용 키트에 관한 것으로, 상기 적어도 두 개의 핵산은 적어도 두 그룹의 핵산에서 선택되고, 상기 그룹은,

그룹 1: 서열번호 1

그룹 3: 서열번호 26, 27, 28 및 29로 이루어진 군에서 선택되는Ensembl 유전자 ID ENSG00000255545.3의 스플라이스 변이체

그룹 4: 서열번호 3 및 11

그룹 5: 서열번호 12

그룹 6: 서열번호 24

그룹 7: 서열번호 36

그룹 8: 서열번호 38로 구성된다.

도 1: 조직 샘플 품질의 검증: 조직 샘플의 종양 세포 함량을 확인하기 위해 도시된 냉동 샘플로부터 동결절편을 제작하였다. HE: 헤마톡실린/에오신(hematoxylin/eosin); IHC: 면역 조직 화학(immunohistochemistry). 조직 샘플 품질의 검증: HE 염색(조직 샘플의 종양 세포 함량을 확인하기 위해), RNA 및 DNA 분리 및 IHC를 위해 도시된 냉동 샘플로부터 4 μm의 동결절편을 제작하였다. HE: 헤마톡실린/에오신; IHC: 면역 조직 화학.
도 2: 전사체 PCA3에 대한 RNA-시퀀싱 데이터의 박스-플롯. 대조군(C)으로서 양성 전립선 비대증의 전립선 조직 샘플 8 개, 각각 그룹 V(매우 낮은 위험도; 글리슨 점수 <7, pN0), 그룹 L(낮은 위험도; 글리슨 점수 <7, pN0), 및 그룹 M(중간 위험도; 글리슨 점수 <=7, pN+)의 PCa 종양 샘플 8 개 및 그룹 H(높은 위험도; 글리슨 점수 >7)의 16 쌍의 종양 및 무종양(tumour-free) 조직 샘플을 포함하는 후향적 PCa 환자 집단의 RNA 시퀀싱 결과.
도 3: 56 개의 전립선 조직 샘플의 qRT-PCR 분석으로부터 생성된 Retro-RPL7(서열번호 1) 및 PCA3의 ROC 곡선.
도 4: 서열번호 12에 대한 맞춤형 마이크로어레이 데이터의 박스-플롯. 대조군으로서 양성 전립선 비대증(BPH)의 전립선 조직 샘플 40 개 및 근치적 전립선 절제술(RPE) 이후 PCa 환자의 종양 및 무종양 조직 샘플 각각 164 개 및 52개를 포함하는 후향적 PCa 환자 집단의 맞춤형 마이크로어레이 분석 결과.
도 5: 도 4에 도시된 256 개의 전립선 조직 샘플의 맞춤형 마이크로어레이 분석으로부터 생성된 서열번호 12의 ROC 곡선.
도 6: 2-전사체 시그니처를 기반으로 하는 로짓 모델(logit model). ROC 곡선은 Retro-RPL7(서열번호 1) 및 XLOC133897(서열번호 2)(AUC = 0.975)을 포함하는 다변량 로짓 모델에 대해 도시된다.
도 7: 바이오마커 시그니처: A) 8 개의 대조군 조직 샘플(양성 전립선 비대증, BPH) 및 서열번호 1, 3, 4-10, 11, 12, 24, 26-29, 36 및 36의 모든 전사체에 대한 40 개의 전립선암종 조직 샘플로부터의 RNA 차세대 염기서열 분석에 의해 얻어진 데이터는 더욱 높은 특이성 및 민감도를 생성하는 시그니처로서 결합되었다. 데이터는 박스-플롯(왼쪽)과 ROC 곡선(오른쪽)으로 도시된다. 생성된 AUC 값은 1.0이다. B) 40 개의 대조군 조직 샘플(양성 전립선 비대증, BPH) 및 서열번호 1, 3, 4-10, 11, 12, 24, 26-29 및 38의 모든 전사체에 대한 164 개의 전립선암종 조직 샘플로부터의 맞춤형 마이크로어레이 분석에 의해 얻어진 데이터는 더욱 높은 특이성 및 민감도를 생성하는 시그니처로서 결합되었다. 데이터는 박스-플롯(왼쪽)과 ROC 곡선(오른쪽)으로 도시된다. 생성된 AUC 값은 1.0이다.
도 8: RNA 차세대 염기서열 분석에 의한 소변 샘플에서의 바이오마커 검출: 비뇨기과 전문의에 의한 환자의 직장 수지 검사 후 소변 샘플을 수득하였다. 이들 샘플로부터 분리된 RNA는 Illumina HiSeq2500 차세대 염기서열 분석기를 사용하여 전사체 전체 RNA 시퀀싱을 받았다. 리드는 표준 알고리즘에 의해 게놈에 매핑되고, 도시된 서열 번호의 게놈 좌위로 매핑된 리드를 계수하고, 소변 내의 전립선 상피 세포의 존재에 대한 척도로서 전립선-특이 항원(PSA)의 유전자 좌위에서 유도된 리드로 정규화하였다. 전립선암 진단을 받은 환자와 그렇지 않은 환자의 샘플을 비교하였다.

다음의 정의는 출원서의 본문에서 사용되는 특정 용어에 대해 제공된다.

본원에서 사용된 "핵산(들)"또는 "핵산 분자"라는 용어는 일반적으로 임의의 리보 핵산 또는 데옥시리보 핵산을 지칭하며, 이는 변형되지 않거나 변형된 DNA일 수 있다. "핵산"은 단일 및 이중 가닥 핵산을 제한 없이 포함한다. 본원에서 사용된 "핵산(들)"이라는 용어는 또한 하나 이상의 변형된 염기를 포함하는 상기한 DNA를 포함한다. 따라서, 안정성을 위해 또는 다른 이유로 개질된 백본을 갖는 DNA는 "핵산"이다. 본원에서 사용된 "핵산"이라는 용어는 핵산의 이러한 화학적, 효소적 또는 대사적 변형 형태뿐만 아니라 예를 들어 단순 및 복합 세포를 포함하는 바이러스 및 세포의 화학적 형태의 DNA 특징을 포함한다.

본 발명의 문맥에서 "수준" 또는 "발현 수준"이라는 용어는 환자의 샘플에 바이오마커가 존재하는 수준에 관한 것이다. 바이오마커의 발현 수준은 일반적으로 이의 발현 수준을 표준화를 위한 표본에서 하나 또는 여러 개의 하우스키핑 유전자의 발현 수준과 비교함으로써 측정된다. 바이오마커의 발현 수준이 적절한 대조군(예를 들어, 건강한 조직)에서 동일한 바이오마커의 발현 수준을 설정된 임계값만큼 초과하는 경우, 환자의 샘플은 양성 전립선암으로 지정된다.

본원에서 사용된 "핵산의 존재 및/또는 수준에 대한 샘플 분석" 또는 "핵산의 수준을 구체적으로 평가하는"이라는 용어는 핵산의 수준을 평가하고 정량화하는데 유용한 수단 및 방법에 관한 것이다. 한 가지 유용한 방법은 예를 들어 정량적 역전사(quantitative reverse transcription, PCR)이다. 마찬가지로, RNA의 수준은 또한 노던 블롯(northern blot), 차세대 염기서열 분석에 의해 또는 260 및 280 nm에서의 흡광도 측정을 포함하는 분광 기술을 사용하여 증폭 후 분석될 수 있다.

본원에 사용된 "증폭된"이라는 용어는 핵산 서열에 적용되는 경우, 핵산 주형 서열로부터 하나 이상의 특정 핵산 서열의 카피가 바람직하게 중합효소 연쇄 반응의 방법에 의해 생성되는 공정을 의미한다. 그 밖의 증폭 방법은 리가아제 연쇄 반응(ligase chain reaction, LCR), 폴리뉴클레오티드-특이적 기반 증폭(polynucleotide-specific based amplification, NSBA), 또는 본 기술 분야에 공지된 임의의 다른 방법을 포함하지만 이에 제한되지 않는다.

진단 및 예후 마커(들)의 사용과 관련하여 본원에서 사용된 "상호 비교하는(correlating)"이라는 용어는 환자의 샘플에서의 마커(들)의 존재 또는 양을, 주어진 질환을 앓거나 앓을 위험에 처한 것으로 알려진 사람의 샘플에서의 이의 존재 또는 발현 수준과 비교하는 것을 의미한다. 환자 샘플에서의 마커 발현 수준은 특정 진단과 관련된 것으로 알려진 수준과 비교될 수 있다.

본원에서 사용된 "진단"이라는 용어는 질병의 발달 단계에서 이 경우 전립선암인 질병의 확인을 의미하며, 또한 질병으로 발전할 경향이 있는 대상의 결정을 포함한다.

"Ensembl 유전자 ID ENSG00000245750.3"이라는 용어는 Ensembl에 의한 유전자 ID 서열 주석과 관련이 있다. 동일한 유전자 ID에 속하는 전사체는 스플라이스 이벤트인 엑손(exon)에서 다를 수 있으며, 매우 다른 단백질을 생성할 수 있다. 이들은 선택적 스플라이싱으로 인해 발생하는 동종형이다. Ensembl 유전자 ID는 예를 들어 RP11-279F6.1 또는 좌위(hg19) Chr15: 69,755,365-69,863,775 (+)와 같은 그 밖의 주석 시스템에서 여러 개의 등가물을 갖는다. 이 Ensembl 주석에 대한 임의의 등가물이 그 대신 사용될 수 있다.

"Ensembl 유전자 ID ENSG00000255545.3"이라는 용어는 Ensembl에 의한 유전자 ID 서열 주석과 관련이 있다. 동일한 유전자 ID에 속하는 전사체는 스플라이스 이벤트인 엑손에서 다를 수 있으며, 매우 다른 단백질을 생성할 수 있다. 이들은 선택적 스플라이싱으로 인해 발생하는 동종형이다.

Ensembl 유전자 ID는 예를 들어 RP11-627G23.1 또는 좌위(hg19) Chr11: 134,306,367-134,375,555 (+)와 같은 그 밖의 주석 시스템에서 여러 개의 등가물을 갖는다. 이 Ensembl 주석에 대한 임의의 등가물이 그 대신 사용될 수 있다.

본원에서 사용된 "형광 염료"라는 용어는 특정 파장의 광 에너지를 흡수하고 상이한 파장의 광을 재-방출하는 임의의 화학 물질을 의미한다. 핵산을 표지화하는데 적합한 형광 염료는 예를 들어 FAM(5- 또는 6-카복시플루오레세인), VIC, NED, 플루오레세인, FITC, IRD-700/800, CY3, CY5, CY3.5, CY5.5, HEX, TET, TAMRA, JOE, ROX, BODIPY TMR, 오레온 그린(Oregon Green), 로다민 그린(Rhodamine Green), 로다민 레드(Rhodamine Red), 텍사스 레드(Texas Red), 야키마 옐로우(Yakima Yellow), 알렉사 플루오르(Alexa Fluor), PET 등을 포함한다.

본원에서 사용된 "분리된(isolated)"이라는 용어는 핵산과 관련하여 사용되는 경우 자연 발생 서열이 정상적인 세포(예를 들어, 염색체) 환경으로부터 제거되거나 비-자연 환경에서 합성(예를 들어, 인공 합성)되는 것을 의미한다. 따라서, "분리된" 서열은 무세포 용액에 있거나 상이한 세포 환경에 놓일 수 있다.

본원에서 사용된 "키트"라는 용어는 조합물 사용에 대한 지시 및/또는 이러한 사용을 위한 그 밖의 반응 및 성분을 선택적으로 포함하는 포장된 조합물이다. 키트가 핵산을 포함하는 경우, 키트는 또한 상기 핵산의 합성 또는 비-천연 변이체를 포함할 수 있다. 합성 또는 비-천연 핵산은 임의의 화학적, 생화학적 또는 생물학적 변형을 포함함으로써, 핵산이 이러한 형태로는 현실적으로 나타나지 않는다는 것으로 이해되어야 한다. 이러한 변형은 형광 염료 또는 퀀처 모이어티(quencher moiety), 비오틴 태그(biotin tag)를 이용한 표지화뿐만 아니라 핵산의 백본(backbone)에서의 변형(들), 또는 요소를 이의 천연 대응물과 구별하는 임의의 다른 변형을 포함하지만 이에 제한되지 않는다. 이는 또한 단백질, 지질 등과 같은 다른 천연 화합물에도 동일하게 적용된다.

본원에서 사용된 "환자"라는 용어는 질병으로 인해 치료를 받고 있거나 받아야 하는 또는 질병이 있는 것으로 의심이 되는 살아 있는 인간 또는 비인간 생물을 말한다. 이는 분명한 병은 없는 사람으로 병리학의 징후에 대해 검사 중인 사람들을 포함한다. 따라서, 본원에 기술된 방법 및 분석은 인간 및 동물 질병 모두에 적용 가능하다.

본원에 사용된 "프라이머"라는 용어는 정제된 제한 분해에서와 같이 자연적으로 발생하든 합성적으로 생성되든지 간에, 핵산 가닥에 상보적인 프라이머 연장 제품의 합성이 유도되는 조건 하에, 즉, 뉴클레오티드 및 DNA 중합효소와 같은 및 유도제의 존재 하에 그리고 적절한 온도 및 pH에 놓일 때 합성의 개시 지점으로 작용할 수 있는 핵산을 의미한다. 프라이머는 단일 가닥 또는 이중 가닥일 수 있고, 유도제의 존재 하에 원하는 연장 산물의 합성을 위해 충분히 길어야 한다. 프라이머의 정확한 길이는 온도, 프라이머의 소스 및 사용된 방법을 포함하는 많은 요소에 따라 달라진다. 바람직하게, 프라이머는 대략 15-100 염기, 더욱 바람직하게는 대략 20-50 염기, 가장 바람직하게는 대략 20-40 염기의 길이를 갖는다. 프라이머의 적절한 길이를 결정하는데 관련된 인자는 본 기술 분야의 숙련자에게 잘 알려져 있다. 선택적으로, 프라이머는 화학적, 생화학적 또는 생물학적 변형을 포함한다는 의미에서 합성 요소일 수 있다. 이러한 변형은 형광 염료 또는 퀀처 모이어티를 이용한 표지화뿐만 아니라 핵산의 백본에서의 변형, 또는 프라이머를 이의 천연 핵산 대응물과 구별하는 임의의 다른 변형을 포함하지만 이에 제한되지 않는다.

"프로브"라는 용어는 핵산, 단백질 또는 지질과 같은 생물학적 개체를 특이적으로 검출하는데 사용될 수 있는 임의의 요소를 의미한다. 프로브가 생물학적 개체에 특이적으로 결합할 수 있게 하는 프로브 부분 이외에, 프로브는 또한 분석에서 검출을 가능하게 하는 적어도 하나의 변형을 포함한다. 이러한 변형은 형광 염료, 특이적으로 도입된 방사성 요소 또는 비오틴 태그와 같은 표지를 포함하지만 이에 제한되지 않는다. 프로브는 또한 잠금 핵산(locked nucleic acid)과 같은, 이의 구조 내의 변형을 포함할 수 있다.

본원에 사용된 "샘플"이라는 용어는 환자와 같은 관심 대상의 진단, 예후 또는 평가의 목적으로 수득된 체액 또는 조직 샘플을 지칭한다. 바람직한 테스트 샘플은 혈액, 혈청, 혈장, 뇌척수액, 소변, 타액, 객담 및 흉막 삼출액을 포함한다. 또한, 본 기술 분야의 숙련자는 분획화 또는 정제 과정, 예를 들어, 혈청 또는 혈장 성분으로의 전혈의 분리 이후 일부 테스트 샘플을 더욱 쉽게 분석할 수 있음을 알 것이다.

따라서, 본 발명의 바람직한 실시형태에서, 샘플은 혈액 샘플, 혈청 샘플, 혈장 샘플, 뇌척수액 샘플, 타액 샘플 및 소변 샘플 또는 상기한 샘플의 임의의 추출물뿐만 아니라 혈액 또는 림프액에서 순환하는 종양 세포, 전이를 포함하는 것으로 의심되는 임의의 조직뿐만 아니라, 엑소좀(exosome), 마이크로베시클(microvesicle) 등과 같은 소포체 및 전립선 종양 세포에서 유래된, 자유- 또는 단백질-결합된 RNA분자를 포함하는 전립선 종양 세포 또는 이의 일부를 포함할 수 있는 임의의 소스로 이루어진 군에서 선택된다. 바람직하게, 샘플은 혈액 샘플이고, 가장 바람직하게는 혈청 샘플 또는 혈장 샘플이다. 중요하게, 소변(특히 직장 수지 검사 이후)과 정액은 가장 바람직한 샘플에 속한다. 조직 샘플은 또한 수술 중에 수득되는 생검 물질 또는 조직 샘플일 수도 있다.

본원에서 사용된 "곡선 아래 면적(area under the curve, AUC)"이라는 용어는 수신기 동작 특성(receiver operating characteristic, ROC)의 곡선 또는 ROC 곡선 아래의 면적을 나타낸다. AUC는 바이오마커가 얼마나 특이적이고 민감한지와 관련이 있다. 완벽한 마커(AUC=1.0)는 100% 민감도(거짓 음성 없음 없음) 및 100% 특이성(거짓 양성 없음)을 나타내는 ROC 공간의 좌측 상단 코너 또는 좌표(0,1)에 점을 생성할 것이다.

"p-값"이라는 용어는 귀무 가설(null hypothesis)이 실제로 참일 때, 즉, 그룹에 대한 평균값 간에 차이가 없을 때 관측된 샘플 결과(또는 더욱 극단적인 결과)를 얻을 확률과 관련이 있다. p-값이 작을수록 대체 가설(alternative hypothesis)이 귀무 가설보다 관찰된 결과를 더욱 잘 설명할 가능성이 높다.

"조정된 p-값"이라는 용어는 다중 비교(테스트된 유전자/프로브의 수)에 대해 조정된 p-값을 말한다. 적용된 방법은 실험 부분에서 자세히 설명한다.

본 발명은 전립선암의 진단 방법을 기술한다. 이 방법은 환자로부터 채취된 샘플을 분석하는 단계 및 상기 환자 샘플에서 바이오마커의 조합의 수준을 구체적으로 결정하는 단계를 포함한다. 각각의 바이오마커에 대한 결과는 이후 임계값과 상호 비교되며, 결과가 해당 임계값보다 큰 경우, 상기 환자 샘플은 전립선암 양성으로 지정된다.

본 발명은 서열번호 1 내지 42를 포함하는 서열의 여러 개의 그룹에 관한 것이다. 공간 제약으로 인해, 처음 100 개의 뉴클레오티드만 나열된다. 서열의 나머지 부분은 서열 프로토콜에서 찾을 수 있다.

특히 본 발명은 다음의 8 개의 별개의 서열 그룹에 관한 것이다:

그룹 1: 서열번호 1

그룹 4: 서열번호 3 및 11

그룹 5: 서열번호 12

그룹 6: 서열번호 24

그룹 7: 서열번호 36

그룹 8: 서열번호 38

서열번호 3 및 11의 핵산 서열은 좌위(hg19): Chr2: 1,550,437-1,629,191 (-)로부터 스플라이싱된 전사체에 해당한다.

서열번호 36 및 38의 전사체는 각각 38,342 뉴클레오티드 및 346,832 뉴클레오티드 길이이다. 본 발명자들은 놀랍게도 이들 두 개의 핵산이 단일의 긴 전사체에 해당한다는 것을 발견하였다. 따라서, 이들 긴 전사체의 임의의 부분의 발현 수준의 검출은 본 발명의 방법에 적합하다.

시퀀스에는 두 가지 유형이 있다. 첫째, 일부 전사체는 관련 데이터베이스에 이미 주석이 달린 알려진 서열이다. 이들은 이들 각각의 주석으로 식별된다. 둘째, 아직 주석을 달리지 않은 새로운 전사체가 확인되었다. 이들은 여기에서 다음과 같이 지정된다. XLOC_ 뒤에 번호가 온다. 이러한 지정은 전사체의 게놈 기원에 대한 정보를 제공하지만 반드시 해당 전사체의 전체 서열을 나타내지는 않는다. 검출된 서열은 어떤 경우에는 더 길거나 더 짧을 수 있다. XLOC 전사의 경우 단편이 발견되면 이들 단편은 1000, 500, 400, 300, 200, 150, 100, 50, 40, 30, 20, 10, 9, 8, 7, 6 또는 5 개의 뉴클레오티드처럼 작을 수 있다.

서열번호(SEQ ID)	전사체	유전자/전사체 주석	서열
1	1	Retro-RPL7 Ensemble-ID gene: ENSG00000242899.1 Locus (hg19): Chr3: 131,962,301-131,963,125 (-) Ensemble-ID transcript(s): ENST00000479738.1	Ttttccggctggaaccatggagggtgttgaagagaagaagaaggttcctgctgtgccagaaacccttaagaaaaagtgaaggaatttcacagagctgaag
2	2	XLOC_133897 Ensemble-ID gene: none Locus (hg19): chr20: 45,377,600-45,380,719 (-) Ensemble-ID transcript(s): none Includes GenBank entries: AK128800.1, BC065739.1	gcccgcttctgtgactccaccccttacggaaagtctatgggactctctgaaatgtatgagtgatactgttagaaagcggcaagaaaatgaaaagaaaacg
3	3	AC144450.2 Ensemble-ID gene: ENSG00000203635.2 Locus (hg19): Chr2: 1,624,282-1,629,191 (-) Ensemble-ID transcript(s): ENST00000366424	attgcccacagccggatccacggtgactaatctccgggaaggcgtccagcgtgagccgtgaggcctgcacctgcgccggacttcaccactcaccaggagt
4	4	RP11-279F6.1 Ensemble-ID gene: ENSG00000245750.3 Locus (hg19): Chr15: 69,755,365-69,863,775 (+) Ensemble ID trancript: ENST00000558633	caggaatgggctggggcgcgtttgtagttgggaatcctgagcccgggctgttgcttggaggactcgggagcagcagtggatttcggcgttaccaggagag
5	4	ENST00000558309	ttcggcgttaccaggagagctatgtataggaatgccgctatggaaagacatccaggacaccttgttaagtgaaaaaagacatgccaccattagggcttca
6	4	ENST00000560882	gaggcccgacattgtgctggggaaggagctccagaaagggccatcctttctgttttggttcagtatctgaacacttttgctaaaggtctctggaaagctc
7	4	ENST00000559029	GactggagaggccagcacgcacagtgacttaatccaagaagatggaataaAaaggcctacctcattgggctcgtgtgggtgaggagaactgaagagtctg
8	4	ENST00000558781	CtgggcttccagcttccaagccttctacctgtggaatgcttggtccaatgTctggggcacccactcttactccaaactcctccagatctgcagagtggcc
9	4	ENST00000498938	Ggagctggttccaggaaagaagggcacatgagcaaacatgatggcccctttatgagaggtaatttactgaaatgcacagcgattacctgctcacccagcc
10	4	ENST00000559477	aggaacttggaataacttgcagtgtcttgcagtattgtgaaaccagcaacTtgttcacaattcttctgaatttcttgggaaatttgaagtggagtacctg
11	5	AC144450.1 Ensemble-ID gene: ENSG00000228613.1 Locus (hg19): Chr2: 1,550,437-1,623,885 (-) Ensemble-ID transcript(s): ENST00000438247.1	cagttttcacaggcctgtgtgccgagagtgttccttaccattttttcattattattctgctaaggaggatttttagacattatgttcctagtcaagccct
12	6	AC012531.25 Ensemble-ID gene: ENSG00000260597.1 Locus (hg19): Chr12: 54,413,694-54,416,373 (+) Ensemble-ID transcript(s): ENST00000562848.1	caagacagaggcaagcagagaaggcatagcagcagcgaccggcgctctgttttcattttccactctggccaggggataaactggaccccagtggactcca
13	7	XLOC_068574 Ensemble-ID gene: none Locus (hg19): chr14: 62,653,302-62,655,723 (+) Ensemble-ID transcript(s): none	ggtaacatgaaaataatggatgagcagttcaactatattaaaaataaacgtggttaagagtgctcaccttaagtgtaggatttgaaagtgtaggctctaa
14	8	RP1-207H1.3 Ensemble-ID gene: ENSG00000231150.1 Locus (hg19): chr6:38,890,805-38,920,875 (-) Ensemble ID transcript: ENST00000416948.1	Tgaagcccatgagccactagaagccacatgttctgccatgtggagaagaatgagagagtacatcctcaaattgaggtgtggcatgatgatttggctgccc
15	8	ENST00000453417.1	ctttcaagggcctgtgcctgtggtaactgtctatgagccaggtatatctgaagcatatttgacaacagaaaaagttaatgtaattttcaaaggaaaaacg
16	8	ENST00000418399.1	atatctgaagcatatttgacaacagaaaaagttaatgtaattttcaaaggaaaaacgccaacttttttcaaaaaggaaacagcaactggagagcagattt
17	9	XLOC_016724 Ensemble-ID gene: none Locus (hg19): chr1: 177,827,793-177,841,757 (-)	atcccctctgagaatttatcagaaaaacaagcaataagtgagaccaacgttgtgaggtattaactcggaaccgtcatctatccttgtggagaaaaacccg
18	10	RP11-314O13.1 Ensemble-ID gene: ENSG00000260896 Locus (hg19): Chr16: 80,862,632-80,926,492 (-) Ensemble ID transcript: ENST00000562231	ttctttttgtttgctgccttccgtagaagatgtggcttgctcatgcttgacttctgccatggttgtgaggcctccccagccatgtggaactgttttcagg
19	10	ENST00000569356	AggggtttccgcttttgcttcttcctcattttctcttgctgctgccatttTcgcctcccgccatgattctgaggcctccccagctatgtggaactgtaag
20	10	ENST00000561519	AaaagactatctcttcccattgaattaaattggaactttggaatcttaatAgaaaaccaactgacttggcttggttttcaggtgctggttccatggctct
21	10	ENST00000563626	CttgctcatgcttgacttctgccatggttgtgaggcctccccagccatgtGgaactgttttcaggtgctggttccatggctcttcctgagccgaaaataa
22	11	XLOC_167596 Ensemble-ID gene: none Locus (hg19): chr4: 67,964,836-67,975,652 (-)	Ctctttctctccttctcccttccttcctccctccctccctctcttcctctcttttctttctttctttctctttctttctttctttctttctttctttctt
23	12	XLOC_167595 Ensemble-ID gene: Locus (hg19): chr4: 67,946,236-67,964,614 (-)	aaacatacgtgtgcatgtgtctttatggcagcatgatttataatcctttggggatatactcagtaatgggatggctgggtcaaatggtatttctagttct
24	13	XLOC_156132 Ensemble-ID gene: none Locus (hg19): chr3: 193,632,725-193,636,178 (-)	agtatgtgcatttgtaccttgctttgttttcctcaactttgtgcttgtttCtgtaattccctcattcattcctacctctgcatgcttgaaagttctttgt
25	14	XLOC_156120 Ensemble-ID gene: none Locus (hg19): chr3: 193,580,748-193,608,459 (-)	accaaaggacatgcgaaaacttttgggtgtgatggatatagtcataatctttattgtggtgactgtttcacacatgtgtacatatatcacaactcatcaa
26	15	RP11-627G23.1 Ensemble-ID gene: ENSG00000255545.3 Locus (hg19): Chr11: 134,306,367-134,375,555 (+) Ensemble ID transcript: ENST00000533390	cttcctcggggtttgcttccaggcctgacttttactcccctttctaagtgtgcagatgggatgtgcttctccacaggaggccccacggcttccccacccc
27	15	ENST00000531319	ctgtctcaagcctccaatcaacagatcagacagcttgtactcacaggccaaggacacgtggaaagaggctcaattttctagatgggtggcaacagccatg
28	15	ENST00000528482	gaggcagccatgactggccacttcatgtgctcctggagaagggcttgcaccagccgttttcaggaaagtcaagcagctgttgactcctgagtctgggtga
29	15	ENST00000532886	caaatgcctggcagcgtcctcggtgcttcacctgccatagccgacagtggctgacctcccatgcctgttgccttttctttctgttggatcagggatacac
30	16	XLOC_047797 Ensemble-ID gene: none Locus (hg19): chr12: 75,378,181-75,383,176 (+)	aagatgggacaattttttttcctcttggtttctttataattattgtaccccttttctggaataatcttttcatcttgttcatctgtcaatgcctgcttgt
31	17	ANKRD34B Ensemble-ID gene: ENSG00000189127.3 Locus (hg19): Chr5: 79,852,574-79,866,307 (-) Ensemble ID transcript: ENST00000338682	agctgctggcccccctgggtccagaggagccttgccgccctcacctgcgcagagcctggagccgacgcgtcacccccagcggaagcgcctcgctgcccgg
32	17	ENST00000508916	agctcagctcagacggcgccctagggccgcacagagggtcgggcagtgccggagagaggtttgaaagcgccgccgccaactcgacagcgcgtcccaggaa
33	18	XLOC_243739 Ensemble-ID gene: none Locus (hg19): chr9: 79,530,077-79,542,427 (-)	aaacaggaaaagaaattgggatttttatgaaaaatgttaaaggctagctctgttaggatttcccatgacattgcagtggtgacatggtcgtggatgtgcc
34	19	XLOC_198292 Ensemble-ID gene: none Locus (hg19): chr6: 148,396,831-148,428,362 (+)	tccctcccttccttccttccttccttcctttcttcccttcagtttctcttccttctaatgccccctgtccttaaaaatgtctccattcaggcactatgca
35	20	XLOC_068639 Ensemble-ID gene: none Locus (hg19): chr14: 62,931,844-62,933,233 (+)	ccaagatttctcatccatggtttcaactaagaatattttattctctccagtgaaattttttacaattaggattgcaaaactacatacattcaggtagatc
36	21	XLOC_172083 Ensemble-ID gene: none Locus (hg19): chr4: 169,961,616-169,999,957 (-)	cactgcagtctctccctccctggttcaagcaattctcttgcctcagtctcctgagtagctgggaccacaggcgctcaccaccacgcatggctcatttttg
37	22	XLOC_172082 Ensemble-ID gene: none Locus (hg19): chr4: 169,947,628-169,961,481 (-)	agtgatccgcccgcctccgcctcccaaagtgctgggattacaggtgtgagccactgcgcctggccgctgctcttatactattttgaatgtaggccggccg
38	23	XLOC_112832 Ensemble-ID gene: none Locus (hg19): chr2: 123,297,707-123,644,538 (+)	agcagatggcatttgagcaaacacttgcaaaaggtgaggaagatagccatcatagctgatggaacaagcaaaacaaaagtcataaggaagaattgtactc
39	24	XLOC_243747 Ensemble-ID gene: none Locus (hg19): chr9: 79,622,778-79,633,361 (-)	cccgcagctgcgccccacccgggccaccaagcacggtggagggggaacaggacactgccttcttgcttctcttctctctggcatctccctcttccgcccc
40	25	XLOC_243744 Ensemble-ID gene: none Locus (hg19): chr9: 79,601,892-79,606,132 (-)	atgtgccaccacacctggctgattttttgtatttttagtagagatgggatatcaccatattaaccaagatggtctcgattacctgacctcgtgatccgcc
41	26	XLOC_126289 Ensemble-ID gene: none Locus (hg19): chr2: 180,988,687-180,989,287 (-)	cctgtgcatctaatttagtggggggcagacctgtttcacaagccaaaataacaggctgcaataactgaggattttatatataccctgaccaaagaagttt
42	27	XLOC_172084 Ensemble-ID gene: none Locus (hg19): chr4: 169,983,995-169,984,246 (-)	attgtggaactgctctttctccctgcgattcagaggggaaaagataaagccacacagccctggggcctcttgcttaagaacacatctcagtttaaccacc

서열번호(SEQ ID NO.) 리스트. 서열번호 1 내지 42는 해당 전사체 및 유전자 주석과 함께 열거된다. 각각의 서열 번호의 처음 100 개의 뉴클레오티드가 표시되어 있다.

바이오마커 PCA3는 전립선암종(prostate carcinoma, PCa) 진단에 일상적으로 사용된다. 따라서, 예상되는 바와 같이, PCA3 발현 수준은 발명자들에 의해 차세대 염기서열 분석에 의해 테스트된 대상에서 PCa의 지표였다(도 2). 그러나, 바이오마커는 매우 낮은 위험 종양(V)에서 가장 높은 발현 수준을 갖고, 종양의 위험 인자가 증가함에 따라 감소하는 것으로 밝혀졌다. 이러한 결과는 PCA3이 중간 위험도 및 높은 위험도의 종양에 대한 신뢰할 수 없는 마커가 되게 하고 더욱 양호한 전립선암 바이오마커에 대한 필요성을 보여준다.

본 발명자들이 발견한 다수의 신규 바이오마커는 특이성 및 민감성 측면에서 PCA3에 비해 상당히 양호하다. Retro-RPL7(서열번호 1)은 예를 들어 PCA3에서의 0.851에 비해 0.935의 곡선 아래 면적(AUC)을 나타내었다(도 3).

서열번호 1 및 서열번호 12의 바이오마커의 조합은 0.985의 AUC를 나타내었다(표 7 참조).

다음 그룹의 바이오마커는 조합시 전립선암에 대해 강력한 지표가 되는 나타나는 것으로 밝혀졌다:

그룹 1: 서열번호 1

그룹 4: 서열번호 3 및 11

그룹 5: 서열번호 12

그룹 6: 서열번호 24

그룹 7: 서열번호 36

그룹 8: 서열번호 38.

여덟 개의 모든 그룹에서 선택된 바이오마커의 조합은 1.0의 AUC를 제공한다(도 6 참조).

따라서, 본 발명은 환자의 샘플에서 적어도 두 개의 핵산의 발현 수준을 분석하는 단계를 포함하는 전립선암의 진단 방법에 관한 것으로, 상기 적어도 두 개의 핵산은 적어도 두 그룹의 핵산에서 선택되고, 상기 그룹은,

그룹 1: 서열번호 1

그룹 4: 서열번호 3 및 11

그룹 5: 서열번호 12

그룹 6: 서열번호 24

그룹 7: 서열번호 36

그룹 8: 서열번호 38로 구성되고,

본 발명은 또한 전립선암의 진단 및/또는 치료 방법에 관한 것으로, 상기 발명은, 환자의 샘플에서 적어도 두 개의 핵산의 발현 수준을 분석하는 단계를 포함하는 단계, 상기 적어도 두 개의 핵산은 적어도 두 그룹의 핵산에서 선택되고, 상기 그룹은,

그룹 1: 서열번호 1

그룹 4: 서열번호 3 및 11

그룹 5: 서열번호 12

그룹 6: 서열번호 24

그룹 7: 서열번호 36

그룹 8: 서열번호 38로 구성되고,

상기 적어도 두 개의 핵산의 발현 수준이 임계값보다 큰 경우, 상기 샘플은 전립선암 양성으로 지정되고; 및 하나 이상의 전립선암 치료제를 환자에게 투여하는 단계를 포함한다.

바람직한 전립선암 치료제는 도세탁셀(Docetaxel (Taxotere®)); 카바지탁셀(Cabazitaxel (Jevtana®)); 미톡산트론(Mitoxantrone (Novantrone®)); 에스트라무스틴(Estramustine (Emcyt®)); 독소루비신(Doxorubicin (Adriamycin®)); 에토포시드(Etoposide (VP-16)); 빈블라스틴(Vinblastine (Velban®)); 파클리탁셀 (Paclitaxel (Taxol®)); 카보플라틴(Carboplatin (Paraplatin®)); 아비라테론 아세테이트(Abiraterone acetate), 비칼루타미드(Bicalutamide), 카소덱스(Casodex), 데가렐릭스(Degarelix), 엔잘루타미드(Enzalutamide), 고세렐린 아세테이트(Goserelin acetate), 류프롤라이드 아세테이트(Leuprolide acetate), 프레드니손(Prednisone), 시플류셀-T(Sipuleucel-T), 라디움 223 디클로라이드(Radium 223 dichloride) 및/또는 비노렐빈(Vinorelbine(Navelbine®))을 포함한다.

바람직한 실시형태에서, 본 발명은 적어도 두 개의 핵산의 발현 수준을 분석하는 단계를 포함하는 전립선암 진단 방법에 관한 것으로, 상기 두 개 이상의 핵산 중 적어도 하나는 그룹 2의 서열번호 4, 5, 6, 7, 8, 9 및 10 및/또는 그룹 1의 서열번호 1에서 선택된다.

본 발명의 또 다른 실시형태에서, 적어도 3 개의 핵산의 발현 수준이 분석되며, 상기 핵산은 적어도 3 개의 상이한 그룹에서 선택된다. 본 발명의 대안적인 실시형태에서, 적어도 4 개의 핵산의 발현 수준이 분석되며, 상기 핵산은 적어도 4 개의 상이한 그룹에서 선택된다. 본 발명의 대안적인 실시형태에서, 적어도 5 개의 핵산의 발현 수준이 분석되며, 상기 핵산은 적어도 5 개의 상이한 그룹에서 선택된다. 본 발명의 대안적인 실시형태에서, 적어도 6 개의 핵산의 발현 수준이 분석되며, 상기 핵산은 적어도 6 개의 상이한 그룹에서 선택된다. 본 발명의 대안적인 실시형태에서, 적어도 7 개의 핵산의 발현 수준이 분석되며, 상기 핵산은 적어도 7 개의 상이한 그룹에서 선택된다. 가장 바람직한 실시형태에서, 각각의 그룹으로부터의 적어도 하나의 핵산의 발현 수준이 분석된다.

샘플은 전립선 조직, 생검 물질, 림프절, 소변, 정액, 혈액, 혈청, 혈장, 혈액 또는 림프액 내의 순환 종양 세포, 전이를 포함하는 것으로 의심되는 임의의 조직뿐만 아니라, 엑소좀, 마이크로베시클 등과 같은 소포체 및 전립선 종양 세포에서 유래된, 자유- 또는 단백질-결합된 RNA분자를 포함하는 전립선 종양 세포 또는 이의 일부를 포함할 수 있는 임의의 소스로 이루어진 군에서 선택될 수 있다. 더욱 바람직하게, 샘플은 소변이고, 가장 바람직하게, 샘플은 직장 수지 검사(digital rectal examination, DRE) 후 환자로부터 수득한 소변이다.

핵산의 정량화를 위한 임의의 적합한 방법은 핵산의 발현 수준을 분석하는데 사용될 수 있다. 일 실시형태에서, 핵산의 정량화는 형광 기반 분석법을 사용하여 수행된다. 바람직한 실시형태에서, 발현 수준의 분석은 표지된 프라이머, 표지된 프로브 또는 형광 검출제의 형광을 측정함으로써 수행된다.

본 발명의 또 다른 실시형태에서, 정량화는 핵산 증폭을 기반으로 하는 분석법을 사용하여 수행된다. 바람직한 실시형태에서, 정량화는 PCR 또는 염기서열 분석법을 사용하여 수행된다. 가장 바람직한 실시형태에서, 핵산의 정량화는 qRT-PCR을 사용하여 수행된다.

대안적인 실시형태에서, 핵산 또는 이의 역 보체에 의해 코딩되는 단백질은 분석되고 정량화된다.

그룹 1: 서열번호 1

그룹 4: 서열번호 3 및 11

그룹 5: 서열번호 12

그룹 6: 서열번호 24

그룹 7: 서열번호 36

그룹 8: 서열번호 38로 구성된다.

키트는 두 개 이상의 핵산을 포함할 수 있다. 바람직한 실시형태에서, 키트는 또한 발현 수준의 분석을 수행하기 위한 시약을 포함한다. 바람직한 실시형태에서, 키트는 추가로 핵산 증폭 및/또는 핵산 정량 및/또는 핵산 검출을 위한 시약을 포함한다. 또 다른 실시형태에서, 키트는 대조 샘플을 포함한다.

실험 결과는 PCa의 검출을 위한 신규한 바이오마커 조합의 높은 특이성과 민감성을 입증한다.

이상적으로, 그룹의 핵산의 전사체의 발현 수준이 하우스키핑 유전자와 같은 샘플 내의 하나 이상의 다른 유전자의 전사 수준과 비교된다. 적절한 하우스키핑 유전자의 예를 아래의 표 2에 나타내었다:

임계값은 샘플이 암 양성으로 지정되는, 테스트 샘플과 대조군 샘플 간의 최소 발현 차이이다.

이상적으로, 테스트 샘플과 대조군 샘플 간의 바이오마커의 발현 레벨 차이는 1.5 배(± 20%), 2 배(± 20%), 3 배(± 20%), 4 배(± 20%) 및 가장 바람직하게는 5 배(± 20%) 이상이다. p-값(T 테스트)은 < 2×10^-5이다. FDR은 바람직하게 < 5×10^-4이다.

선택된 유전자 그룹에 대해, 임계값은 바람직하게는 종양 및 대조군 샘플 간에 2 배(± 20%)의 발현 증가이다.

본 발명은 RNA 바이오마커 수준의 분석에 관한 것이다. 이는 예를 들어 정량적 역전사(quantitative reverse transcription, PCR)와 같은 PCR 기반 방법을 포함하는 여러 가지 방법으로 달성될 수 있다.

본 발명은 바이오마커의 수준을 특이적으로 결정하기 위한 증폭 방법에 관한 것이다. 본원에서, 샘플은 다음의 서열 그룹에서 선택되는 서열의 핵산에 특이적인 순방향 및 역방향 프라이머와 혼합되고:

그룹 1: 서열번호 1

그룹 4: 서열번호 3 및 11

그룹 5: 서열번호 12

그룹 6: 서열번호 24

그룹 7: 서열번호 36

그룹 8: 서열번호 38,

증폭 사이클이 수행된다. 프로브 또는 프라이머는 엄격한 조건 하에서 상기 표적 서열과 혼성화되도록 설계된다. 적어도 두 개의 증폭 반응은 병렬로 또는 다중 증폭 형태로 수행될 수 있다.

일 실시형태에서, 방법에서의 분석은 표지된 프라이머, 표지된 프로브 또는 형광 검출제의 형광을 측정함으로써 수행된다. 더욱 바람직하게, 발현 수준의 분석은 qRT-PCR에 의해 수행된다.

또 다른 실시형태에서, 적어도 두 개의 핵산의 발현 수준의 분석은 염기서열 분석법을 사용하여 수행된다.

본 발명은 또한 조합에 포함된 바이오마커의 발현 수준의 정량화에 관한 것이다. 증폭 후, 정량화는 간단하며 다수의 방법으로 달성될 수 있다. 적어도 하나의 프라이머에 형광 염료가 부착된 프라이머를 사용하는 경우, 염료로부터의 형광 신호를 사용하여 정량화가 가능하다. SYBR 그린, 다중 프로브, TaqMan 프로브, 분자 비콘 및 스콜피온(Scorpion) 프라이머와 같은 다양한 프라이머 시스템과 염료가 이용 가능하다. 그 밖의 가능한 정량화 수단은 예를 들어 노던 블롯팅(Northern blotting), 차세대 염기서열 분석 또는 260 및 280 nm에서의 흡광도 측정이다.

아래의 실시예로부터 명백해지는 바와 같이, 본 발명은 현재의 바이오마커보다 더욱 정확하고 민감한 질병 진단을 가능하게 하는 전립선암에 대한 바이오마커 조합을 개시한다.

실시예

임상 환자 집단( clinical cohort )

드레스덴 대학 병원에서 근치적 전립선 절제술(radical prostatectomy, RPE) 또는 양성 전립선 비대증(benign prostate hyperplasia, BPH)을 제거하기 위해 수술을 받은 전립선암종(prostate carcinoma, PCa) 환자들이 PCa에 대한 신규한 바이오마커를 확인하기 위한 후향적 임상 환자 집단에 포함되었다. 지역 윤리위원회의 승인 및 환자로부터의 사전 동의를 법규에 따라 받았다. PCa 환자의 경우, 적어도 5년 동안의 임상적 경과에 대한 데이터를 수집하였다.

게놈 전체의 RNA 염기서열 분석에 의해 진단학적으로 관련이 있는 바이오마커를 식별하기 위해 40 명의 PCa 환자와 8 명의 BPH 환자 집단의 전립선 조직 샘플을 사용하였다. 네 개의 PCa 그룹을 글리슨(Gleason)에 따른 병기(staging)를 기반으로 정의하였다(The Veteran’s Administration Cooperative Urologic Research Group: histologic grading and clinical staging of prostatic carcinoma; in Tannenbaum, M. Urologic Pathology: The Prostate, Philadelphia: Lea and Febiger. Pp. 171-198) as well as the presence of metastases in the adjacent lymph nodes upon RPE(표 3 참조. ).

그룹	C	V	L	M	H
글리슨 점수	BPH	GS<7	SG=7	GS<=7	GS>7
림프절 전이	-	pN0	0pN	pN+	pN0		pN+
조직	대조군	종양	종양	종양	종양	무종양	종양	무종양
샘플 수	8	8	8	8	8	8	8	8

게놈 전체의 RNA 염기서열 분석을 위한 PCa 환자 집단: 대조군(C)은 BPH 샘플로 구성된다. 매우 낮은 위험도(V) 및 낮은 위험도(L) 그룹은 각각 글리슨 점수(Gleason Score, GS)가 7 미만 및 7인 환자의 샘플을 포함하며, 이들 환자 모두는 림프절 전이가 없다(pN0). 중간 위험도(M) 그룹은 GS가 7 이하이고 림프절 전이를 보이는(pN+) 경우를 포함하며; 높은 위험도(H) 그룹은 GS가 7 초과인 조직으로 구성된다. 후자의 경우, 동일한 환자에게서 수득한 종양 및 무종양 조직 샘플의 쌍을 분석하였다.

선택된 바이오마커 후보 물질은 각각 256 명의 환자(40 개의 대조군 BPH 샘플, 216 개의 종양 샘플) 및 56 명의 환자(16 개의 대조군 BPH 샘플, 40 개의 종양 샘플)를 포함하는 환자 집단에 대한 주문형 마이크로어레이 및 정량적 역전사 실시간 PCR(qRT-PCR)에 의해 더 검증되었다.

전립선 조직 샘플

드레스덴 대학 병원의 비뇨기과에서 수행한 수술에서 전립선 조직 샘플을 수득하였고 드레스덴 대학의 종합 암 센터에 액체 질소로 보관하였다. 전립선암종(PCa) 환자의 근치적 전립선 절제술(RPE)에서 수득한 전립선 조직 샘플을 종양 샘플 및 무종양 샘플로 나누었다. 양성 전립선 비대증(BPH) 환자의 전립선 조직 샘플을 비-종양 대조군으로 사용하였다. 항상 환자의 동의를 받았다.

샘플 및 종양 세포 내용물의 상태를 확인하기 위해 모든 샘플을 일련의 동결절편(cryosection)으로 나누었다. 이를 위해, 냉동 조직 샘플을 티슈-텍 OCT-화합물(Tissue-Tek OCT-compound, Sakura Finetek GmbH)에 포매하고 동결시켜 금속 압입기에 고정시켰다. 동결절편은 -28℃로 냉각된 마이크로톰 블레이드 C35(FEATHER)가 장착된 동결조직 절편기(cryomicrotome, Leica)를 사용하여 제작하였다. 모든 샘플을 총 208 개의 동결절편으로 절단하였고, 그 중 4 개를 HE 염색하였고 종양 세포 내용물에 대해 병리학자가 평가하였다(도 1). 이는 연속적인 동결절편의 3 개의 스택을 제작하였고, 이들 각각은 HE-염색 부위에 측면에 위치하였다. 적어도 60% 또는 최대 5%의 종양 세포를 포함하는 부위의 양측에 위치하는 스택만을 종양 또는 무종양 샘플로 각각 사용하였다. 이후 선택된 스택의 50 개의 동결절편에 대해 RNA 준비하였다.

RNA 분리

총 RNA는 수동 DNase I 분해와 함께 Qiazol 및 QIAcube 상의 miRNeasy Mini Kit(모두 Qiagen사 제품)를 사용하여 냉동 보관한 조직에서 분리하였다. RNA 농도는 Nanodrop 1000(Peqlab)을 사용하여 측정하였다. RNA 무결성은 Agilent Bioanalyzer 2100(Agilent Technologies, Palo Alto, CA)으로 검증하였으며, RNA-무결성 번호(RNA-Integrity-Number, RIN)가 적어도 6인 RNA 샘플만을 추가로 처리하였다.

게놈 전체 길이 RNA 차세대 염기서열 분석

대조군으로서 양성 전립선 비대증(BPH)의 8 개의 전립선 조직 샘플 및 56 개의 종양 조직 샘플(글리슨 점수가 7 초과인 샘플로부터의 종양 및 무종양 조직 쌍을 포함)을 포함하는 후향적 PCa 환자 집단의 하위 집합을 사용하여 게놈 전체 길이 RNA 시퀀싱을 수행하였다. Ribo-Zero rRNA Removal Kit(Epicenter)를 사용하여 1 μg의 총 RNA 1로 리보솜 RNA를 고갈시켰다. ScriptSeq v2 RNA-Seq Library Preparation Kit(Epicentre)를 사용하여 50 ng의 rRNA-고갈된 RNA로 시퀀싱 라이브러리를 제작하였다. Agencourt AMPure XP System Kit(Beckman Coulter)를 사용하여 디-태그된(di-tagged) cDNA를 정제하였다. 샘플 다중화를 위해 인덱스 바코드를 통합하고 cDNA 라이브러리를 증폭시키기 위해 10 사이클을 통해 PCR을 수행하였다. 증폭된 라이브러리의 품질과 농도는 Agilent Bioanalyzer(Agilent Technologies) 상에서 DNA High Sensitivity Kit를 사용하여 결정하였다. 각각 4 ng의 8 개 샘플을 모으고 아가로스 겔 전기영동을 사용하여 2% 아가로스 겔 상에서 크기를 선택하였다. 150 bp와 600 bp 간의 샘플 범위를 겔 절제하고 제조사의 지침에 따라 MinElute Gel Extraction Kit(Qiagen)로 정제하였다. DNA High Sensitivity Chip(Agilent Technologies)을 사용하여 Agilent Bioanalyzer 상에서 정제된 라이브러리를 정량화하였다. 정제되고 크기가 선택된 모든 라이브러리 풀을 Illumina HiSeq2000 유동 세포 측정기 상에 로딩하여 모든 레인에 분배하였다. 클러스터 생성은 제조사의 프로토콜에 따라 Illumina cBOT 장비에서 TruSeq PE Cluster Kits v3(Illumina Inc.)을 사용하여 수행하였다. 염기서열 분석은 Illumina HiSeq2000 염기서열 분석기(Illumina, Inc.)에서 수행하였다. 염기서열 분석 실행의 세부 사항은 다음과 같다: 페어드-엔드 시퀀싱 전략; 리드1(Read1)에 대해 101 사이클, 인덱스 서열에 대해 7 사이클, 및 리드2에 대해 101 사이클.

시퀀싱 데이터 분석: 원시(Raw) 데이터 준비

베이스 콜 파일(base call file, BCL 파일)을 포함하는 원시 시퀀싱 데이터를 CASAVA v1.8.1(Illumina)로 처리하여 FASTQ 파일을 생성하였다. FASTQ 파일은 각각 임상 샘플에 대해 이하에서 "리드(read)"이라고 불리는 모든 서열화된 RNA 단편을 포함한다. 특정 어댑터 서열은 cutadapt(http://code.***.com/p/cutadapt/)를 사용하여 제거하였다.

시퀀싱 데이터 분석: 게놈 매핑 및 전사체 (transcript) 조립

리드는 segemehl v0.1.4-382 및 TopHat v2.0.9를 사용하여 인간 게놈(어셈블리 hg19)에 매핑하였다. 새로운 전사체, 즉 Gencode v17에 주석이 달리지 않은 전사체는 Cufflinks v2.1.1 및 Cuffmerge v2.1.1을 사용하여 조립하였다. 모든 새로운 전사체와 모든 알려진 Gencode v17 전사체는 종합주석 세트(comprehensive annotation)로 결합하였다.

시퀀싱 데이터 분석: 통계 분석

Htseq-count v0.5.4p1(http://www-huber.embl.de/users/anders/HTSeq/doc/count.html)을 사용하여 신규 및 공지된 전사체의 종합 주석 세트에 포함된 전사체 및 유전자당 리드 수를 계산하였다. R 및 Bioconductor 라이브러리 edgeR을 사용하여 차별적으로 발현된 전사체와 유전자를 확인하였다. 임상 샘플의 다양한 RNA 조성을 각각의 샘플에 대한 라이브러리 크기를 조정하여 조정하였다(TMM 방법). 음이항 로그 선형 모델(negative binomial log-linear model)을 각각 전사체 또는 유전자의 리드 수 및 우도비 검정(likelihood ratio test)에 의해 확인된 0 이외의 계수에 맞추었다. 허위 발견율은 Benjanimi-Hochberg 조정에 의해 통제하였다.

맞춤형 마이크로어레이에 의한 검증

염기서열 분석 결과를 바탕으로 mRNA, 긴 비-코딩 RNA(gencode v15), 새로운 전사체 및 모든 차등 발현 전사체를 포함하는 180,000 개의 프로브(Agilent SurePrint G3 Custom Exon Array, 4x180K, Design-ID 058029)를 구비한 맞춤형 마이크로어레이를 설계하였다.

근치적 전립선 절제술 이후 PCa 환자의 164 개 및 52 개의 종양 및 무종양 조직 샘플뿐만 아니라 대조군으로 양성 전립선 비대증으로부터의 40 개의 전립선 조직 샘플을 포함하는 후향적 PCa 환자 집단을 사용하여 마이크로어레이 스크리닝을 수행하였다. Quick Amp Labeling Kit(Agilent)를 사용하여, 200 ng의 총 RNA로 cRNA를 합성하였으며, 어레이(Agilent Gene Expression Hybridization Kit)에서 1650 ng의 cRNA를 혼성화하였다.

정량적 실시간 PCR 에 의한 검증

차세대 염기서열 분석 및 마이크로어레이 스크리닝으로 얻어진 결과의 검증을 위해, 총 56 개의 조직 샘플(16 개의 무종양 샘플 및 40 개의 종양 샘플)을 정량적 실시간 PCR을 사용하여 선별하였다.

제조자의 지시에 따라 High-Capacity Reverse transcription kit(Applied Biosystems) 및 랜덤 프라이머를 사용하여 100 ng의 총 RNA로 cDNA를 합성하였다. 4 μl의 희석된 cDNA를 사용하여 후속 PCR 분석을 수행하였다. Applied Biosystems 7900HT Real-Time PCR System에서 하우스키핑 및 표적 전사체에 대해 맞춤형 및 사전-설계된 TaqMan Gene Expression Assays(Applied Biosystems)를 사용하여 정량적 실시간 PCR을 수행하였다.

모든 샘플을 세 번 측정하였고, 이들 측정치의 평균을 추후 계산에 사용하였다.

	하우스키핑/표적 명칭	TaqMan 분석 ID
하우스키핑	GAPDH	Hs02758991_g1
	HPRT1	Hs02800695_m1
	HMBS	Hs00609293_g1
표적	서열번호 1	AJ70L28
	서열번호 9	Hs01388451_m1
	서열번호 3	AJCSVRJ
	PCA3	Hs01371939_g1

전립선 조직 샘플에서 qRT-PCR 검증에 사용된 Applied Biosystems TaqMan Gene Expression Assays의 ID.

RT - qPCR 결과의 통계 분석

조절되지 않은 하우스키핑 유전자 GAPDH(서열번호 1) 및 HPRT1(서열번호 3 및 서열번호 9)에 대해 데이터 정규화를 수행하였다. 상대적 정량화를 위해, 각각의 샘플의 유전자 발현의 변화를 대조군 샘플의 중간 발현과 비교하여 분석하였다. 모든 통계 분석은 R 통계 소프트웨어를 사용하여 수행하였다.

바이오마커의 log2-변환된 상대 발현 수준을 Student's t-test를 사용하여 종양 및 대조군 샘플 간에 비교하였다. 곡선 아래 면적(AUC)에 의한 각각의 마커의 진단력의 척도를 나타내는 수신가 동작 특성(receiver-operating characteristic, ROC) 곡선은 pROC 패키지를 사용하여 계산하였다.

DRE 소변 샘플의 검증

DRE 소변 샘플 채취 및 RNA 분리

소변 샘플은 전립선의 직장 수지 검사(digital rectal examination, DRE) 후 수집되었다(DRE 소변). 일상적으로 수행되는 검사 방법을 통해 일정량의 전립선 세포를 포함하는 소변 샘플을 얻을 수 있다. DRE 소변 샘플을 원심 분리하고 PBS로 두 번 세척하였다. 생성된 세포 펠릿을 700 μl Qiazol에 재현탁시켰다. 총 RNA는 수동 DNase I 분해와 함께 Qiazol 및 QIAcube 상의 miRNeasy Mini Kit(모두 Qiagen사 제품)를 사용하여 분리하였다. RNA 농도는 Nanodrop 1000(Peqlab)을 사용하여 측정하였다. RNA 무결성은 Agilent Bioanalyzer 2100(Agilent Technologies, Palo Alto, CA)으로 검증하였다.

DRE 소변 샘플의 정량적 실시간 PCR 스크리닝

제조자의 지시에 따라 슈퍼스크립트 III 역전사 효소(Applied Biosystems) 및 랜덤 프라이머를 사용하여 2×50 ng의 총 RNA로부터 cDNA를 합성하였다. 4 μl의 cDNA를 사용하여 후속 PCR 분석을 수행하였다. Applied Biosystems 7900HT Real-Time PCR System에서 하우스키핑 및 표적 전사체에 대해 맞춤형 및 사전-설계된 TaqMan Gene Expression Assays(Applied Biosystems)를 사용하여 정량적 실시간 PCR을 수행하였다.

모든 샘플을 두 번 측정하였고, 이들 측정치의 평균을 추후 계산에 사용하였다.

DRE 소변 샘플의 게놈 전체 길이 RNA 차세대 염기서열 분석

게놈 전체 길이 RNA 시퀀싱을 위해 7 개의 DRE 소변 샘플의 총 RNA를 에탄올을 사용하여 침전시켜 RNA 양을 농축하고 RNase가 없는 10 μl의 물에 재현탁시켰다. rRNA 제거는 Low input Ribo-Zero rRNA Removal Kit (Epicentre modified by clontech)를 사용하여 4 ng의 총 RNA로 수행하여, 10 μl의 rRNA-고갈된 RNA를 만들었다. 시퀀싱 라이브러리는 SMARTER stranded RNAseq Kit(Clontech)를 사용하여 8 μl rRNA-고갈된 RNA로부터 제작하였다. Agencourt AMPure XP System Kit(Beckman Coulter)를 사용하여 디-태그된 cDNA를 정제하였다. 샘플 다중화를 위해 인덱스 바코드를 통합하고 cDNA 라이브러리를 증폭시키기 위해 18 사이클을 통해 PCR을 수행하였다. 증폭된 라이브러리의 품질과 농도는 Agilent Bioanalyzer(Agilent Technologies) 상에서 DNA High Sensitivity Kit를 사용하여 결정하였다. 샘플을 모으고 클러스터 생성은 제조사의 프로토콜에 따라 Illumina cBOT 장비에서 15 pmol/l의 풀링된 라이브러리와 TruSeq PE Cluster Kit v4(Illumina Inc.)를 사용하여 수행하였다. 염기서열 분석은 Illumina HiSeq2500 서열 분석기(Illumina, Inc.)에서 HiSeq SBS v4 염기서열 분석 시약(250 사이클)을 사용하여 수행하였다다. 염기서열 분석 실행의 세부 사항은 다음과 같다: 페어드-엔드 시퀀싱 전략; 리드1에 대해 126 사이클, 인덱스 서열에 대해 7 사이클, 및 리드2에 대해 126 사이클.

DRE 소변에서 qRT - PCR 결과의 통계 분석

DRE 소변 샘플의 qRT-PCR 결과의 분석을 위해, 전립선 특이 항원(PSA)에 대해 데이터 정규화를 수행하였다. 상대적 정량화를 위해, 각각의 샘플의 유전자 발현의 변화를 대조군 샘플의 중간 발현과 비교하여 분석하였다. 모든 통계 분석은 R 통계 소프트웨어를 사용하여 수행하였다.

	명칭	TaqMan 분석 ID
하우스키핑	GAPDH	Hs02758991_g1
하우스키핑	HPRT1	Hs02800695_m1
표적	SeqID 1	AJ70L28
표적	PSA	Hs02576345_m1

qRT-PCR 검증에 사용된 Applied Biosystems TaqMan Gene Expression Assays의 ID.

결과

RPE에서 수득한 40 개의 종양 샘플 및 16 개의 무종양 샘플 및 양성 비-종양 대조군으로 8 개의 BPH 전립선 조직 샘플의 전사체를 가닥-특이적 페어드-엔드 길이 RNA 차세대 염기서열 분석(next generation sequencing, NGS)을 사용하여 분석하였다. 최적의 데이터 품질과 분석의 견고성을 목표로 적어도 세 개의 세그먼트에서 샘플당 대략 150 개의 동결절편을 제작하였다. 병리학적 평가에서, 종양 및 무종양 샘플에서 각각 60% 및 5%의 최대 및 최소 종양 세포수를 충족하는 세그먼트만을 추가 분석을 위해 보유하였다. 전사체 염기서열 분석법(RNAseq)은 정상 또는 암 전립선 조직에서 발현되는 RNA의 포괄적인 동정 및 정량화를 목표로 한다. 폴리아데닐화 상태와는 무관하게 모든 종류의 코딩 및 긴 비-코딩 전사체를 서열 분석하였다. 라이브러리의 복잡성을 높이기 위해 대량의 RNA를 사용하였다. 또한, 평균 200 M 페어드-엔드 리드 상에서 라이브러리당 2×100 nt가 분석되어, 높은 커버리지로 인해 소량으로 발현된 새로운 전사체를 조립할 수 있게 되었다. 이러한 접근법은 더 많은 수의 샘플을 분석한 대부분의 비교 가능한 공지된 연구보다 더 나은 결과를 제공하였다. 전체적으로, Gencode v17에 주석이 달린 전사체와의 엑손 중복을 보이지 않은 대략 3,000 개의 새로운 전사체를 조립하였다. 허위 발견율이 0.01일 때, 모든 대비에 걸쳐 6,442 개의 차별적으로 발현된 유전자가 관찰되었다. 특정 대비에 차별적으로 발현된 유전자의 유전자의 수를 표 4에 나타내었다.

대비	총수	단백질 코딩	lineRNA	안티센스	센스- 인트론	유사 유전자	신규한 바이오마커	비-단백질 코딩
종양 대 대조군	5615	3882	116	96	13	456	847	1733
종양 글리슨>7 vs 대조군	2677	1812	73	40	4	88	552	865
종양 높음 및 중간 vs 종양 낮음 및 매우 낮음	138	51	3	2	0	7	72	87
종양 글리슨=7 vs 종양 글리슨 종양 글리슨<7	12	6	0	1	0	0	5	6
종양 글리슨>7 vs 종양 글리슨=7	14	7	0	0	0	1	6	7

다양한 대비 및 Gencode biotype에 대해 차별적으로 발현된 유전자의 수.

결과는 전립선 종양과 정상 조직 사이에서 차별적으로 발현되는 것으로 이전에 보고된 대다수의 전사체를 성공적으로 재생하였다. 또한, 많은 수의 PCa 관련된 새로운 전사체가 확인되었으며, 이는 PCa의 진단을 위한 분석을 개발하는데 사용될 수 있다. 선정된 가장 유망한 전사체는 qRT-PCR에 의한 PCA 종양 및 BPH 대조군 샘플의 테스트 환자 집단에서 유효성이 입증되었다.

이러한 신규한 바이오마커 후보 물질 중 일부는 이미 PCa 진단에 사용되고 있는 바이오마커 PCA3의 특이성과 민감도를 훨씬 능가한다. 염기서열 분석 환자 집단에서, PCA3는 PCa와 분명히 관련되어 있음이 입증되었지만, 고-위험군에서의 감소 경향은 강했다(도 2).

테스트 환자 집단에서, 신규한 바이오마커 Retro-RPL7(서열번호 1)은 PCA3에서의 0.851에 비해 0.935의 곡선 아래 면적(AUC)을 나타내었다(도 3). 본 발명자들의 신규한 바이오마커인 Retro-RPL7 및 XLOC133897의 조합은 0.975의 AUC를 나타내었다(도 6).

실험 결과는 PCa 검출을 위한 신규한 바이오마커의 높은 특이성과 민감성을 입증한다. 따라서, PCa의 진단에 사용될 전립선 종양 세포 또는 이의 일부(엑소좀, 마이크로베시클 등과 같은 소포체 및 전립선 종양 세포에서 유래된, 자유- 또는 단백질-결합된 RNA분자를 포함함)를 포함할 수 있는 모든 소스에서 이러한 새롭게 발견된 바이오마커 단독 또는 조합(또는 이미 알려진 마커와의 조합)의 측정을 기반으로 분석을 설정할 수 있다. 이들 소스에는 전립선 조직, 생검 물질, 림프절, 소변, 정액, 혈액, 혈청, 혈장, 혈액 또는 림프액 내의 순환 종양 세포뿐만 아니라 PCa 전이를 포함하는 것으로 의심되는 임의의 조직을 포함하지만 이에 제한되지 않는다. 본 발명자들의 RNA 바이오마커의 측정은 RNA 수준을 구체적으로 평가하기에 적합한 방법, 예를 들어, qRT-PCR과 같은 PCR 기반 방법에 의해 이루어질 수 있다. PCa의 조기 진단(스크리닝), 종양의 공격성 예측(예후) 및/또는 치료의 선택을 위해 이러한 분석이 적용될 수 있다.

이러한 바이오마커를 기반으로 하는 진단 분석법은 따라서 현재의 검사의 허위 양성률을 크게 낮추고 이에 따라 불필요한 침습적인 전립선 생검을 피하는데 도움을 준다.

그룹 1: 서열번호 1

그룹 2: 서열번호 4, 5, 6, 7, 8, 9 및 10로 이루어진 군에서 선택되는 Ensembl 유전자 ID ENSG00000245750.3의 스플라이스 변이체

그룹 4: 서열번호 3 및 11

그룹 5: 서열번호 12

그룹 6: 서열번호 24

그룹 7: 서열번호 36

그룹 8: 서열번호 38로 이루어진 군으로부터 선택된 바이오마커의 조합은 또한 이들의 진단 값에 대해서도 분석되었다. 본 발명자들은 상기 그룹들의 조합이 아래의 표 및 도 7에 도시된 바와 같이 분석될 때, 진단 값 및 AUC가 크게 증가한다는 것을 발견하였다. 이는 단일의 신규한 바이오마커가 이전에 공지된 바이오마커보다 우수할 뿐만 아니라 놀랍게도 PCa 진단의 좀더 실질적인 개선을 제공한다는 것을 나타낸다.

Seq A		Seq B	AUC 값

SeqID 12			0.817

SeqID 12	+	SeqID 1	0.985
SeqID 12	+	SeqID 3	0.959
SeqID 12	+	SeqID 11	0.96
SeqID 12	+	SeqID 4_10	0.989
SeqID 12	+	SeqID 38	0.896
SeqID 12	+	SeqID 36	0.944

그룹 5 단독의 AUC 값 대비 그룹 5의 서열을 포함하는 마커 조합의 AUC 값. 데이터는 256 개의 전립선 조직 샘플에 대한 맞춤형 마이크로어레이 분석에서 도출.

Seq A		Seq B	AUC 어레이

SeqID 4_10			0.959

SeqID 4_10	+	SeqID 26_29	0.981
SeqID 4_10	+	SeqID 12	0.989
SeqID 4_10	+	SeqID 38	0.98
SeqID 4_10	+	SeqID 36	0.988

그룹 2 단독의 AUC 값 대비 그룹 2의 서열을 포함하는 마커 조합의 AUC 값. 데이터는 256 개의 전립선 조직 샘플에 대한 맞춤형 마이크로어레이 분석에서 도출.

Seq A		Seq B	AUC 어레이

SeqID 26_29			0.849

SeqID 26_29	+	SeqID 12	0.926
SeqID 26_29	+	SeqID 38	0.915
SeqID 26_29	+	SeqID 36	0.954
SeqID 26_29	+	SeqID 4_10	0.981
SeqID 26_29	+	SeqID 1	0.985
SeqID 26_29	+	SeqID 3	0.962
SeqID 26_29	+	SeqID 11	0.963

그룹 3 단독의 AUC 값 대비 그룹 3의 서열을 포함하는 마커 조합의 AUC 값. 데이터는 256 개의 전립선 조직 샘플에 대한 맞춤형 마이크로어레이 분석에서 도출.

Seq A		Seq B	AUC 어레이

SeqID 3			0.935

SeqID 3	+	SeqID 1	0.984
SeqID 3	+	SeqID 4_10	0.981
SeqID 3	+	SeqID 11	0.946
SeqID 3	+	SeqID 12	0.959
SeqID 3	+	SeqID 26_29	0.962
SeqID 3	+	SeqID 36	0.974
SeqID 3	+	SeqID 38	0.958

그룹 4 단독의 AUC 값 대비 그룹 4의 서열을 포함하는 마커 조합의 AUC 값. 데이터는 256 개의 전립선 조직 샘플에 대한 맞춤형 마이크로어레이 분석에서 도출

Seq A		Seq B	AUC 어레이

SeqID 1			0.945

SeqID 1	+	SeqID 3	0.984
SeqID 1	+	SeqID 4_10	0.986
SeqID 1	+	SeqID 11	0.983
SeqID 1	+	SeqID 12	0.985
SeqID 1	+	SeqID 26_29	0.985
SeqID 1	+	SeqID 36	0.986
SeqID 1	+	SeqID 38	0.983

그룹 1 단독의 AUC 값 대비 그룹 1의 서열을 포함하는 마커 조합의 AUC 값. 데이터는 256 개의 전립선 조직 샘플에 대한 맞춤형 마이크로어레이 분석에서 도출

Seq A		Seq B	AUC 시퀀싱

SeqID 24			0.919

SeqID 24	+	SeqID 1	1
SeqID 24	+	SeqID 3	0.984
SeqID 24	+	SeqID 11	0.975
SeqID 24	+	SeqID 12	1
SeqID 24	+	SeqID 4_10	0.988
SeqID 24	+	SeqID 26_29	0.962
SeqID 24	+	SeqID 36	0.959
SeqID 24	+	SeqID 38	0.966

그룹 6 단독의 AUC 값 대비 그룹 6의 서열을 포함하는 마커 조합의 AUC 값. 데이터는 64 개의 전립선 조직 샘플에 대한 RNA 차세대 염기서열 분석에서 도출.

Seq A		Seq B	AUC 값

SeqID 38			0.806
		SeqID 36	0.88
SeqID 38	+	SeqID 36	0.958

그룹 7 또는 8 단독의 AUC 값 대비 그룹 7 및 8의 서열을 포함하는 마커 조합의 AUC 값. 데이터는 256 개의 전립선 조직 샘플에 대한 맞춤형 마이크로어레이 분석에서 도출.

본 발명자들은 또한 모든 그룹의 발현이 환자의 소변 샘플에서 검출될 수 있는 반면, 건강한 환자에서는 부재하거나 낮게 발현될 수 있음을 발견하였다(도 8). 이는 PSA의 mRNA가 이들 샘플에서 PCa 환자보다 건강한 환자에서 더욱 빈번하게 과발현되는 것으로 밝혀졌기 때문에, Fontenete 등(Int. braz j urol. vol.37 no.6 Rio de Janeiro Nov./Dec. 2011)이 소변 샘플의 전립선암에 적합한 바이오마커가 아니라는 것을 보여 주었기 때문에 놀라운 일이다. 따라서, 소변 샘플에서 바이오마커 발현 수준을 분석하는 것이 전립선암을 확실하게 진단하기 위해 사용될 수 있다는 것은 선험적으로 명확하지 않았다.

이들 바이오마커의 조합을 기반으로 하는 진단 분석법의 장점은 현재의 분석법에 비해 현저히 낮은 허위 양성률을 나타내며 소변 샘플에서의 발현 수준의 측정은 불필요한 침습적인 전립선 생검을 수행하지 않아도 된다.

SEQUENCE LISTING <110> Fraunhofer-Gesellschaft zur F?derung der angewandten Forschung e. V. <120> Novel RNA-biomarker signature for diagnosis of prostate cancer <130> B176-0002WO1 <150> EP14195709.2 <151> 01.12.2014 <160> 42 <170> PatentIn version 3.5 <210> 1 <211> 825 <212> DNA <213> Homo sapiens <400> 1 ttttccggct ggaaccatgg agggtgttga agagaagaag aaggttcctg ctgtgccaga 60 aacccttaag aaaaagtgaa ggaatttcac agagctgaag atcaagcgcc tgagaaataa 120 gtttgcccaa aagatgcttc taaaggcaag gaggaagctt atctatgaaa aagcaaagca 180 ctatcacaag gaatatatgc agatgtacag aactgaaatt caaatatcga ggatggcaag 240 aaaagctggc aacttctatg tatctgcaga acccaaattg gcgtttgtca tcaggatcgg 300 aggttatcaa ttgggtgagc ccaaaggtct gaaaggtgtt gcaacttctt tgccttcatc 360 aaatcttcaa tagaaacttt gtgaagctca gcagggcttc aataatgtgc tgaggtttgt 420 agaaccatat attgcatggg catacccaaa tctgaagtca gtaaataaac taatctacaa 480 atgtggttat agcaaaatga ataagaagct acttgctcca acagataata ctttgattgc 540 tcgatctctt ggtaaatatg gcctcatctg catggaggat ctgattcatg agatctatac 600 tgttggaaaa tgcttaaaga agcaaataac ttcctgtggc ccttcaaatt atcctctcga 660 caagttagaa tgaagaaaaa gaccaccaat tttgtagaag gtggagatgc tgacaacagg 720 gaagaccaga tcaacaggct tattagaaga ataaacatgc ctaccacaat tattttttgt 780 aatctagcca gttaataaac agtacctgct ctcaaattga aaaaa 825 <210> 2 <211> 3120 <212> DNA <213> Homo sapiens <400> 2 gcccgcttct gtgactccac cccttacgga aagtctatgg gactctctga aatgtatgag 60 tgatactgtt agaaagcggc aagaaaatga aaagaaaacg tggatgtttt ccatatttga 120 gttgatgcag gctggagaca acagctgcca gagctgcaag gcagaacacc ctgagaagtg 180 gaaccggagg atccaggcgc ctgttgaagg gataaatgag agccgtggcg tgtggatggg 240 actctttctg tcttccgttt ggctgaagct ccaaacgcca ggagtaaccc agtgggtagc 300 aagcaccctt ccctccacct ctgcaggaat tgcaaaaagc aatggtaaaa aaattggttt 360 gtgatcctta ccccagtgct caaggaggtt ggagaagctg aaagagagga ctggttttga 420 tatggtttgg atttgtgtcc ccacccaaat ctcatgtcaa atggtaatcc ccagtgttgg 480 aggagggact ggtgggaggt gattggatca tgggggcgaa tttccccttg ctgttctcgt 540 gatagtgagt gagttctcat cagatctgat tgcttagaag tgtgtagtgc tggccgggtg 600 cggtggctca cgcctgtaat cccagcactt tgggaggcca aggcgggcag atcatgagat 660 caggagatag agaccatcct ggccaacatg gtgaaacccc gtctctacta aaaatataaa 720 aattagctgg gcgtggtggc gtgtgcctgt agtctcagct gcttgggagg ctgaggcagg 780 agaatagctt gaacctggga ggcggaggtt gcagtgagcc gagatcgtgc cactgcactc 840 cagcctggcg acagagcaag actccatctc aaaaaaaaaa aaaaaaaaaa aaaaaagaag 900 tgtgtagtgc ctcccacctc tctctcttcc tcctgcccca gccatgtgaa cacattcctt 960 ctttcccttt gccttgctcc gtgagtgtaa gtttcctgag gcctcctcag ccatgcttcc 1020 tgtatagcct gcagaactgt gggccagtta aacctctttt ctttgtaaat tacccagtct 1080 caggtatttt ttttagcagt gcgagaacga agggactaat acaggtttgg agacacgtct 1140 ttggagaaac tattgatact tggcgtcctg tggcatttcc ttgccattag cacctccaac 1200 gttatgctgg agaaaaagcc gttccaactc ttcaccgaac gccgagtcag agagatgtgg 1260 ggaaaccacc gaaagagctt gccctgtgtc ttctggacag actagtgcca aacccatgcc 1320 tggaaatggg tagaagttag ggaccatggc cgctcagcct ctgcaggaaa atggattact 1380 gcatcaggaa tgatgacttt agagaaggcc aaaggtgtaa gtttcttcca gcaggttctg 1440 aacctccaga ggcagctggc ctggggttat ttgggattcc cagtgcagga ctgcctgaaa 1500 atgtgaggcg cccaaatggg gctgctggac cacaggatgc ccaggacctg caggcacact 1560 caagagtggc ctgccagagg agacacattg cctgcctccc aggaagcaaa tttggaggtt 1620 gccagtggga gaattgccaa gaaccgccat ccctcccctg ggacacacaa gctaaggaaa 1680 gaaggaattg gccctctaag tccagaaagc acaagatcac atcatcacaa caccagccaa 1740 gtaaaacatc cctgctcctc acctcttcag agcccaaggg ggctggggag gagaagaaat 1800 gagagtggag gaggaaagag gtttaatatg aatgaagttt ggagttttga catgactcga 1860 cattctaatg acttcattta gactgttgct acactcagaa gtgacttgga gacattttat 1920 ttttataatc atcaccatat tgttattggt catgatctaa gggtgaggag aagggctaaa 1980 ggatcggccc aatggatcat tcggggaaag taaagaacta tcccaccagt tgtgtttgaa 2040 tgggcagtga gagggaaaat caagttgcta cttgcacccc tctaactccc aacttccact 2100 ctttcaacat accagacatg aaagctgagt aaatgacctc aaaggtacag cgatgacagg 2160 gtgtggtggt ggtagttctt ggtttcctac attgcatctt caaatcgggt tttagaatgg 2220 atgacactgg aaggctagaa atctcaggta ctgacatgtg ggctggttta taattgtctt 2280 caaaaattca cccacaatag gatcagacaa gttagtatgg ccataggtgc tacaatggga 2340 gaaagtttta aatgctgttc agatcggaag acatgggtca aaaagatcaa gaagagttga 2400 catgaggcaa acattttata tctccattca agagctacct gatgaggttt cacccatcag 2460 ggatacaatg agaatttact gggcgcctag cactgtgcag acacaattca agcaaaaggc 2520 aaccaactct ggcatccaag tgcaggccag cagccaagtt cttcctcctt atgagctgac 2580 atctgattga cagatggccc cagagaaagc ttcttggatc atatctcagt aaccactggc 2640 ccagcctgtc aaatccagag atttaagatg gcatagcacc ttaaatctgg aagaacttag 2700 caactttata atgtcaaatc cagggggaaa atacgcacac agagaaacca gaaaagcata 2760 gaatggtggg gagaaagaaa gaaagaaaat gaaaacactg tttccatcgg cagaattagc 2820 ctttgccagg aaaactgcaa tgttgtcttg gtaggcacat aattcatttt tctacatgtt 2880 cagaagtaaa gaaaaagcca gacccaaaaa gccagaccct gggggaaatc gtggatactg 2940 tttgtaactt tggcaaagac aatatatttg tgaactcagc ctcatgtgaa atgcttgata 3000 atctcaaaaa gtaaatgcca cagcgtgtcg tatactgtgt ggtctcaatg atgtgagaat 3060 gtctatatat cccaatacct gtcctcgttt ctaactagct tgatttattg tcatagacaa 3120 <210> 3 <211> 1641 <212> DNA <213> Homo sapiens <400> 3 attgcccaca gccggatcca cggtgactaa tctccgggaa ggcgtccagc gtgagccgtg 60 aggcctgcac ctgcgccgga cttcaccact caccaggagt ctctgcccgc cgcccccagc 120 gcggttctct tccctgctag acgtaaagtc ctggggacaa gcacagccca gggcactttc 180 tggagagaag atttcgatgg ggaaagataa gagagcattt ggatatctac gcactgtcaa 240 cagaaatgag gcttcaggcc aaggcttcta aaatgcagga ttcccaaagt ggcagtcaca 300 taagacgggt ccctccatcg ccttctagaa tattgagaag atcatcacgc ctgggactgg 360 ctcacagcac tgatcttttt cttgttagca gagactccag gaagcagatg agcagaccta 420 tgggcctgct atgtgcaccg cggcccacac tgccgcctgc ctgggatcct gcatcacccg 480 agtcttcctg cggaccaccc tgggtggtgc acatgcggtc atcattgtgc aaaggaagct 540 ttagttctat aatgaaagcc cctttagtaa gtgatgctcc ttgaagactc ggtcagcgtc 600 tcgttcacct ctttatcccc agacttagca caattccagc cccaaatcgg caacggacct 660 ttgaccaagt gacatgtcag tgcttcaggg agcttcactg atcaggacag aagtgagtga 720 ctggaggaag gtgacccgga tgtctgtaac ccccagaaag ggtgagatgg ctgttttatc 780 agccagcatt gccgagttgg tggtgtgacg acatcctgtc tgactgctgg gccttaccgg 840 tgtgttctct gctggagccg tgacagtttg agttgaggac attttacatc aatcactgaa 900 ctgcacgaaa gatggaaatc cagcaaggga ccccgtcgga cctgattgac cgcagagcta 960 ccttttgctc tttctggatg ccacacggcc tcctcctccc acctgtcctt ggagcttgtg 1020 ttggtccact ttcatgctgc tgataaagcc atacctgaga ctgggtaatt tataaagaaa 1080 aagaggttga atggactcac agttccacgt ggctggggag gcctcacaat cacggcggaa 1140 gttgaaaggc acgtcttaca tggcggcagg caagagagaa tgagagccaa gcaaaggggg 1200 tttcccctta tagaaccatc agatcagctg ggcgcagtgg ctcactcctg taatcccagc 1260 actttgggat gctgaggtgg gaggatcaca aggtcaggag tttgagacca gcctgaccaa 1320 tatggtgaaa ccccatctct actaaaaata caaaaattat ctgggcatgg tggtgggcac 1380 ctgtagtccc agctactcgg gaggctgagg caggagaatc gcttgaacct gggaggcgga 1440 ggttgcagtg agctgagatt gtgccactgc actctagcct gggcaacaaa gcgagacgct 1500 gtctcaaaaa aacaaaaaca aaaacaaaaa aaaccatcag atctcatgag acttattcac 1560 taccatgaga acagtatggg ggaaaccacc ctcatgattc aattatctct tgctgggtcc 1620 ctccctcaac acatgggaat t 1641 <210> 4 <211> 826 <212> DNA <213> Homo sapiens <400> 4 caggaatggg ctggggcgcg tttgtagttg ggaatcctga gcccgggctg ttgcttggag 60 gactcgggag cagcagtgga tttcggcgtt accaggagag ctatgtatag gaatgccgct 120 atggaaagac atccaggaca ccttgttaag tgaaaaaagg ttcagtatct gaacactttt 180 gctaaaggtc tctggaaagc tccctgtgtt aattctcgat gagactacgt ctgtgccggc 240 cgcttcctga gcctccttcc atgtgcatag gcctgctgca tgctggagac ctgcggcaca 300 gctgccaagt gccccgtgtg gttctgtgat cttgggacag tcacttcctc tctgtggttg 360 tcagtcttct catccctaag atggaataaa aaggcctacc tcattgggct cgtgtgggtg 420 aggagaactg aagagtctga gagcgcggca cgagccagag gctacggaaa acactgccct 480 cctacactcc accttggaga gacccagaaa agaacaagct tcatttgtaa aaaaggaaaa 540 caactcaggc aatgggggtg gcttaaaggc actctacagt gtgcagatgc cttccacttc 600 ttccatctgc cctgtctctc caagaacccc tatggccccg gtctcagaac agagctgagt 660 gcagaaatga aaatctatgg ctctgtgttc caaaacgatg aagaatttca agatggtggc 720 agtggtaaaa tctttctcca ggaaaaatct gtccttggcc caatgtgtaa acacttgctg 780 aggaacttgg aataacttgc agtgtcttgc agtattgtga aaccag 826 <210> 5 <211> 806 <212> DNA <213> Homo sapiens <400> 5 ttcggcgtta ccaggagagc tatgtatagg aatgccgcta tggaaagaca tccaggacac 60 cttgttaagt gaaaaaagac atgccaccat tagggcttca tttccctgca gtcttcttta 120 aataccaaaa ctgccctggg aaggataaga catcagtttc ttcatacttc agagcaaatg 180 ggattgattc ccaggacctc ctttctgtgg actgggtttt tgcctcctca ccaagagact 240 gggctccctg ggcgagcaga ggctgctggg ttcagtatct gaacactttt gctaaaggtc 300 tctggaaagc tccctgtgtt aattctcgat gagactacgt ctgtgccggc cgcttcctga 360 gcctccttcc atgtgcatag gcctgctgca tgctggagac ctgcggcaca gctgccaagt 420 gccccgtgtg gttctgtgat cttgggacag tcacttcctc tctgtggttg tcagtcttct 480 catccctaag cactcaagaa gcccttcctt ctctggctgt caagtctgga ctcatctctt 540 gtcttacaca cggacagttg ttttaaggaa aagcccctgg ttggacttgc agattgggca 600 cagccctgga cgtatactac aggtgctcat caaggcttgc ctcatctgtt taccctccag 660 gtcatgcccc tttctacctc tacaccctgt tgcattgcgg gcatggcctc cggaaaagtc 720 aagcatggcg aaaggaagcg tggcccagag ctggcacgcc acaggaactt ggaataactt 780 gcagtgtctt gcagtattgt gaaacc 806 <210> 6 <211> 1358 <212> DNA <213> Homo sapiens <400> 6 gaggcccgac attgtgctgg ggaaggagct ccagaaaggg ccatcctttc tgttttggtt 60 cagtatctga acacttttgc taaaggtctc tggaaagctc cctgtgttaa ttctcgatga 120 gactacgtct gtgccggccg cttcctgagc ctccttccat gtgcataggc ctgctgcatg 180 ctggagacct gcggcacagc tgccaagtgc cccgtgtggt tctgtgatct tgggacagtc 240 acttcctctc tgtggttgtc agtcttctca tccctaagat ggaataaaaa ggcctacctc 300 attgggctcg tgtgggtgag gagaactgaa gagtctgaga gcgcggcacg agccagaggc 360 tacggaaaac actgccctcc tacactccac cttggagaga cccagaaaag aacaagcttc 420 atttgtaaaa aaggaaaaca actcaggcaa tgggggtggc ttaaaggcac tctacagtgt 480 gcagatgcct tccacttctt ccatctgccc tgtctctcca agaaccccta tggccccggt 540 ctcagaacag agctgagtgc agaaatgaaa atctatggct ctgtgttcca aaacgatgaa 600 gaatttcaag atggtggcag tggtaaaatc tttctccagg aaaaatctgt ccttggccca 660 atgtgtaaac acttgctgag gaacttggaa taacttgcag tgtcttgcag tattgtgaaa 720 ccagcaactt gttcacaatt cttctgaatt tcttgggaaa tttgaagtgg agtacctgta 780 ccaacatgaa atgacacgaa tttaagtgac gctcaacaac gaaaagcaaa aagaaccaaa 840 gaggaagcaa ctgaaacaac atctggatgt atttaaaaat atacaatgcc tccaaaatca 900 ggtgtcatta atgaaaattc tgaagaaatg ccaccggaca tagccaacgc acctacgctg 960 ttgttattca tttcctgctt ttcacagaaa acaattttgt tgcatggaag atcgtgaact 1020 tcaaagggca gaggggaaac tgtcccttgg cctctacccc tccaaggccc cacttttttg 1080 tcaacactcc ttggacgcag cagaagtatg aacataatat ggtcctgaat gaggctgagt 1140 ctttgggcgc agaagacccg ggttaataaa aataggaagg taagaaaaga aaagaaaaat 1200 caagacacat cataggacta aattcctatt atttatccac tcaggattga ccaccccttt 1260 gggccagata gttgtacccc catgtaccag gtgggcacat gaagacacaa gaagtgctgt 1320 gatggttcat tttgcacgtc accttgcgtg gagtatgc 1358 <210> 7 <211> 309 <212> DNA <213> Homo sapiens <400> 7 gactggagag gccagcacgc acagtgactt aatccaagaa gatggaataa aaaggcctac 60 ctcattgggc tcgtgtgggt gaggagaact gaagagtctg agagcgcggc acgagccaga 120 ggctacggaa aacactgccc tcctacactc caccttggag agacccagaa aagaacaagc 180 ttcatttgta aaaaaggaaa acaactcagg caatgggggt ggcttaaagg cactctacag 240 tgtgcagatg ccttccactt cttccatctg ccctgtctct ccaagaaccc ctatggcccc 300 ggtctcaga 309 <210> 8 <211> 1222 <212> DNA <213> Homo sapiens <400> 8 ctgggcttcc agcttccaag ccttctacct gtggaatgct tggtccaatg tctggggcac 60 ccactcttac tccaaactcc tccagatctg cagagtggcc cagcatattc tcttcttgaa 120 aggaggtctt tgcctaacag aaatggaata aaaaggccta cctcattggg ctcgtgtggg 180 tgaggagaac tgaagagtct gagagcgcgg cacgagccag aggctacgga aaacactgcc 240 ctcctacact ccaccttgga gagacccaga aaagaacaag cttcatttgt aaaaaaggaa 300 aacaactcag gcaatggggg tggcttaaag gcactctaca gtgtgcagat gccttccact 360 tcttccatct gccctgtctc tccaagaacc cctatggccc cggtctcaga acagagctga 420 gtgcagaaat gaaaatctat ggctctgtgt tccaaaacga tgaagaattt caagatggtg 480 gcagtggtaa aatctttctc caggaaaaat ctgtccttgg cccaatgtgt aaacacttgc 540 tgaggaactt ggaataactt gcagtgtctt gcagtattgt gaaaccagca acttgttcac 600 aattcttctg aatttcttgg gaaatttgaa gtggagtacc tgtaccaaca tgaaatgaca 660 cgaatttaag tgacgctcaa caacgaaaag caaaaagaac caaagaggaa gcaactgaaa 720 caacatctgg atgtatttaa aaatatacaa tgcctccaaa atcaggtgtc attaatgaaa 780 attctgaaga aatgccaccg gacatagcca acgcacctac gctgttgtta ttcatttcct 840 gcttttcaca gaaaacaatt ttgttgcatg gaagatcgtg aacttcaaag ggcagagggg 900 aaactgtccc ttggcctcta cccctccaag gccccacttt tttgtcaaca ctccttggac 960 gcagcagaag tatgaacata atatggtcct gaatgaggct gagtctttgg gcgcagaaga 1020 cccgggttaa taaaaatagg aaggtaagaa aagaaaagaa aaatcaagac acatcatagg 1080 actaaattcc tattatttat ccactcagga ttgaccaccc ctttgggcca gatagttgta 1140 cccccatgta ccaggtgggc acatgaagac acaagaagtg ctgtgatggt tcattttgca 1200 cgtcaccttg cgtggagtat gc 1222 <210> 9 <211> 1345 <212> DNA <213> Homo sapiens <400> 9 ggagctggtt ccaggaaaga agggcacatg agcaaacatg atggcccctt tatgagaggt 60 aatttactga aatgcacagc gattacctgc tcacccagcc ctgatgtaat taaaaatggc 120 aggctagggg ctctgtttcc cccggctctg gcagagaaac ctgggtttcg acttgtgaag 180 cttgaggttg gatgtgggaa ttggcttgga gtcataggcg atgagaggga cattaggata 240 ttatgaagcc cgtgaactca actcctgaga aggacgcagc agagcgagag aaaagatgga 300 ataaaaaggc ctacctcatt gggctcgtgt gggtgaggag aactgaagag tctgagagcg 360 cggcacgagc cagaggctac ggaaaacact gccctcctac actccacctt ggagagaccc 420 agaaaagaac aagcttcatt tgtaaaaaag gaaaacaact caggcaatgg gggtggctta 480 aaggcactct acagtgtgca gatgccttcc acttcttcca tctgccctgt ctctccaaga 540 acccctatgg ccccggtctc agaacagagc tgagtgcaga aatgaaaatc tatggctctg 600 tgttccaaaa cgatgaagaa tttcaagatg gtggcagtgg taaaatcttt ctccaggaaa 660 aatctgtcct tggcccaatg tgtaaacact tgctgagtat tgtgaaacca gcaacttgtt 720 cacaattctt ctgaatttct tgggaaattt gaagtggagt acctgtacca acatgaaatg 780 acacgaattt aagtgacgct caacaacgaa aagcaaaaag aaccaaagag gaagcaactg 840 aaacaacatc tggatgtatt taaaaatata caatgcctcc aaaatcaggt gtcattaatg 900 aaaattctga agaaatgcca ccggacatag ccaacgcacc tacgctgttg ttattcattt 960 cctgcttttc acagaaaaca attttgttgc atggaagatc gtgaacttca aagggcagag 1020 gggaaactgt cccttggcct ctacccctcc aaggccccac ttttttgtca acactccttg 1080 gacgcagcag aagtatgaac ataatatggt cctgaatgag gctgagtctt tgggcgcaga 1140 agacccgggt taataaaaat aggaaggtaa gaaaagaaaa gaaaaatcaa gacacatcat 1200 aggactaaat tcctattatt tatccactca ggattgacca cccctttggg ccagatagtt 1260 gtacccccat gtaccaggtg ggcacatgaa gacacaagaa gtgctgtgat ggttcatttt 1320 gcacgtcacc ttgcgtggag tatgc 1345 <210> 10 <211> 1033 <212> DNA <213> Homo sapiens <400> 10 aggaacttgg aataacttgc agtgtcttgc agtattgtga aaccagcaac ttgttcacaa 60 ttcttctgaa tttcttggga aatttgaagt ggagtacctg taccaacatg aaatgacacg 120 aatttaagtg acgctcaaca acgaaaagca aaaagaacca aagaggaagc aactgaaaca 180 acatctggat gtatttaaaa atatacaatg cctccaaaat caggtgtcat taatgaaaat 240 tctgaagaaa tgccaccgga catagccaac gcacctacgc tgttgttatt catttcctgc 300 ttttcacaga aaacaatttt gttgcatgga agatcgtgaa cttcaaaggg cagaggggaa 360 actgtccctt ggcctctacc cctccaaggc cccacttttt tgtcaacact ccttggacgc 420 agcagaagta tgaacataat atggtcctga atgaggctga gtctttgggc gcagaagacc 480 cgggttaata aaaataggaa ggtaagaaaa gaaaagaaaa atcaagacac atcataggac 540 taaattccta ttatttatcc actcaggatt gaccacccct ttgggccaga tagttgtacc 600 cccatgtacc aggtgggcac atgaagacac aagaagtgct gtgatggttc attttgcacg 660 tcaccttgcg tggagtatgc caactcattg tttggtcaaa cactagtctg gacatggtgg 720 taaaggtatt ttttagatga gattaacact taaatcagta aagcaggtta cccaccatac 780 tacgggtggg ccctgtccaa tcagttgaag gcattaagaa caaagattga ggtttcctaa 840 agaagatgga attctccttg agactacaac atagaaaccc tatctgagtt tccagcctgt 900 tgccctgtgg aattcaaact caggactccg gtctatgaca ttaaccctca cttaactttt 960 cagcctgcca gcctgcccta tggatttcgg acttgccagc cacacaattc cttaaaataa 1020 atctctccgt ctc 1033 <210> 11 <211> 786 <212> DNA <213> Homo sapiens <400> 11 cagttttcac aggcctgtgt gccgagagtg ttccttacca ttttttcatt attattctgc 60 taaggaggat ttttagacat tatgttccta gtcaagccct cacctctgca atgaaattat 120 aataccactg ttgacccaaa gatgagcagc aagcgctaga actgagggaa atcatggtga 180 gatttattct gagccaagct ggaggactta ggcccaggaa cacagaatct gtgtccactg 240 agaatgtatc tcaaagcagg ctccatgagg caccgtgcac ttacattttc taacaggcgg 300 acgtatgtgg cccagaaggt gggagaggca agcggtgagc agccgtgacg ttcctgagat 360 tctgatgagc gctcggtggc actgcccaca tgataaggga gacatgagac atcaatcaac 420 acatgtagga tgaacattgg ttcggtctgg aaaggcggga caactcgaag caaaggcagg 480 aagactcgaa gcagacgggg gcttccaggt cataggaagt catgagcgaa gagaccgtga 540 gcctctccca aaccccgcat gtgctgacat ctccacgtgt gctgtgtcct gggtaggctt 600 tcttcataga ccgtgcttcc gtctgtctgg agtttccgct tcatccatct gtccacaggg 660 aggacgcaca cccctgagtc cgaggccaca ccacgcattc tgtagaaact ctcactgccc 720 agggagcaca ctttattagg aaagctccag gttcacagag gctctgggct ctctctgggc 780 ccgacg 786 <210> 12 <211> 2680 <212> DNA <213> Homo sapiens <400> 12 caagacagag gcaagcagag aaggcatagc agcagcgacc ggcgctctgt tttcattttc 60 cactctggcc aggggataaa ctggacccca gtggactcca acaccaactc tctgcttccc 120 agttactttc gattttcttt cccttctcct tctttctctc cctctctggc attcaaacag 180 aagcacaaga ggacccacca gtggcaactc taagcctcct tgcaggccac attccctgct 240 gacgtggtcc ttcctgcagg agagcccttc tgtgattatc taataatagc cagggtggct 300 gagaatagaa tctggctcaa ggactctgca cacccggggc agagacactg aatctgtggg 360 tcagggcctg gcaacattcc ttggagcctc cccctctgag cccactcttt gggcaccctt 420 aggcttgcct gcccccctta taaggggctt tgtcagccct gccatccgct gtatttcatg 480 tgctggttcc tagctaagga gaattgggca gagcaaaccc tttctcaccc tggtctgaca 540 gttgtgatcc cgacagaatg cgaccttgtt tggagaaggc gaccttgttg ggttggctgt 600 gttctgaaac caggcttggg agtgttatat atttattata tacaggctta aatatacaga 660 ctcaggctta tgcatgaata tatacagact catatttcct tggtggttaa ttgtatatta 720 ccatgcctat attcgctcaa acaccatttt atgttcatgc aaaattttgt tagtcctcac 780 tagatgagag tgggctcatg gaggcaccgg gtgcactgag caggccctct gtgcatgctc 840 tgctggaaat atgtgctcac tggaatcgga gtatgcgggt tccagtaacc aatggatgcc 900 ataaaggctt tctcagacct tattgctttt gttgcccaag cagctggact ggggaaatac 960 taaatccctt ctgctttctc tccacacctc ctggcaaact ctcccaactt agaaattatt 1020 ttacaaggga gaccagttgt cttgaaattg agttctgcgg gattcttttc acgggcatgg 1080 tggggctgca agcagttcgg agtagtcagg gccctggcgc tggaagcctc actggagcga 1140 tgaagggatc agagtggtta ataaggtggc ctctggacag tgatctgggg cagctgctgg 1200 ccagggtgct tggagaagct tgtggaaaag gcaagccaaa aggggtaggg atgcagtgaa 1260 tatctgtttc tccccctgct tgccccagcc ggccgctcac cccgccccag cccgatttgc 1320 ctgcatccgt ggcggcagat tgggagttct ctaaggtccc ccaaataccc agatctggtt 1380 actggatgaa ctgcgtttta atcctcgtcg ctatctgagc caggacaaga cctggtcagg 1440 gagacggctg gtccgggcag cacgggagag gacgctggac ccgctgcctg tggcctggag 1500 cactgagtat gggctaccaa ggctgagaat tgatgggcct cctttcccag cctttttccc 1560 ttccagagac acaaaaagac agagcagagg ggaaatatca atgtcagtgg aaaaccccat 1620 aaaagaaagc agggaccaga gcggggctgg aggggttttc cgctactctc tctaggtgat 1680 cgggttcctc ccaagactct tgtccagaca ggctgcacca agaggtgtgc agctttcttc 1740 caccttcctc ccgcccttca aggagggcag ccttaggctt tctgggcctt ggtcacccca 1800 ggcactgggg tgacattact ccaggattgt gcccctcgcc cagcccacgg cctctgccac 1860 ggcgccgcag ccgctcctgt ttattgtgtc tgtgagttgt ttacttgttt tgtctgctgc 1920 caccctgcgt cagaaacccg ccaaaccagc gaactcgccc aggagaacaa agtgctgtgc 1980 tatccccgga ctccctcccc tttccagcaa ccccctcctg ccctcacaag ctcctgcatt 2040 ctccctttcg gaggggagga agcagaaata gtcttaaaac agggcagctg tttatagggt 2100 caggggaatt atggggacac cataaacctc tgggtgtccc tgtggtggac agacttctga 2160 gcagcccttc ccttgcctag gcttttcttc cttcccctgg tgaccacttg gttaaggggg 2220 ccacactcat tgagaaagtt gagcccaccc ccatcaaccc agtcccccac taccccactc 2280 ctttctgcag gagtttccct gagacacagg ttgttgggtt ttaaatcagg gtaatgttgg 2340 tggattcata aagctagata tagcatgtca ttcttctccc acactccctc tcctcagccc 2400 cccaaaattg cagtgaattt aagcaaatcc tacaaaatta aattgcccct ttgctaaaga 2460 tcctatatgt ctccaatcct gccaggtgta gagtcagata gttggctttt ggcctttaat 2520 tttgctgcta gctattaaat ttaaaagagt atcattgaag taagtaatat tctcatttct 2580 gaaattaatt ttcccctccc agtctctctc tctctctttt tgccagcaca gattaaatgg 2640 ttctttcaga tctgcaaaca ataaaggata aaattattta 2680 <210> 13 <211> 2422 <212> DNA <213> Homo sapiens <400> 13 ggtaacatga aaataatgga tgagcagttc aactatatta aaaataaacg tggttaagag 60 tgctcacctt aagtgtagga tttgaaagtg taggctctaa agtcagactg ggttcggaac 120 ctggtatcat tactgacttg gtgtgtagct tctctatttc tcagtctatt taacctttct 180 catccagaaa atagtgataa taatgctgtt tatctcatag agttgtcgtg agaattaagt 240 gagttaattt gggtacagtg tttttaacag tcaggcacat ggtgtgtcca acaaatgttg 300 gctattagaa ttgtgatggt ttctcctata gttcgagatt ttagtctctg caaagtaaaa 360 gacttagagg ggggaagctg cccctttcag atgtggtgtg gcatttattt ccaagtgcac 420 gtgtgagtct tctgtcttgg taactctcca gtgtggtcat tagtgttttc cagttggtta 480 gtgtgtctct tctcttccaa tagcaagata ggtgtttcaa attcctaggg cttctatcag 540 cacacatgag ggggcttctg tcccttggtg agcactggct tgtttataag cctacaaaca 600 gcactgtgtg ctcaatattc tgtctgcacc tctagattta cctccattct tcaccctgat 660 ttttgccccc agcaggctga cctctaagga tcccctggct cctgtgcctt ctatattctg 720 gttggagtca aagggagttg cagggaggca atcagagagc aggaggagag agatgctatg 780 ggattatctc ctccacccca acacattcct tttcttctgg gctgcagtct ggcagcggct 840 gcattcctct actaaatgcc acaactcctt tcaagtggct cctgtctgac aacttcctgc 900 tgggttccag tggctgctct ttctcttgcc ccttcagatc tgaaggactc ctctgttttc 960 tagttctagg tactgccact tacctgttcc cttatctctt gccacacctc ggtagtccct 1020 ttattgaaag ttcttcagct atcctctttg agcacactgt ttcctagctg gtacatattg 1080 accttgagaa ggttgatgct tcctcaccta cttactgttg ggaagaaaat ggaatatttt 1140 aactgctcct gcaatgtcaa tacagaatcg gccctttcaa agtccagtgc cataggatat 1200 gaagagcatt gctagaacag cgggacatga atgttctacg tggctaaata caatgatctc 1260 cagtataaaa acccaaatgg tcaaagatga actcaaagga ttggagtgaa cacaggtttt 1320 attattactc ttagaacact ctgggttata aaagaactta cattctttaa cataattctg 1380 ttgttttgat actaacgttt agtgcccatt ggatggcagt gccaggaata aaatgtctga 1440 attaagctag tgggggtgat tgagtttatg gccaggagct acattggaga gagagccatg 1500 tcagtagcct aacactggca agacagtgac ccaagtactc tagacttgga tgtttttgat 1560 aggttctttg gaaaaacctc ttctaggtcg ttaagaaagt ttgaaaggct ttagtggttt 1620 aattagataa aatgtagcag aaggcaatat aacataggca cccatagaaa ggagggcaat 1680 ggtttataag agcttgactc tggctcacat ctgagagaca agaaaacata aatccttcag 1740 tcagatcctt ttatgggacc cactttcctc atagattagt ttatgtaaaa actccagtaa 1800 agaatagcac agagacctct gtttgtatgt ttgatgattt tactgttagg gttttattac 1860 ttggttcatg tgcccgagga agtgaacggg tccatgaagg atatatttgt gaggttaaag 1920 ccacatgtag tttatttaac ttttgcagtt ttccaatttg ggtctatatt tcaaccccga 1980 attttctaat ttggggtcta catttcaatc aaaaagatta aatttctttt cctctgtgtt 2040 tgtggatctc tctgggcgcc acccttaaaa ttagcatcat ggttcccatg gcaactaacg 2100 tacctggaag atggcaagaa aggaaaagga ctaaataaaa tagaatgaag ctgcatctga 2160 aaaactggaa ttaattatga acttgaacaa agggttatac tgcaagtggt tggggagatg 2220 agtattaagc atataaggtc tttgctttaa gacctctgta attcacttac catttcatta 2280 ctttgtttat tcagcagccc ccaaatcact gctagttttc ttttccctct caccttcaat 2340 agagaacatc attggggtca ggactgtgca tagttcagga cgagtttacc tctacagggt 2400 gcattttgta agatgtcccc aa 2422 <210> 14 <211> 830 <212> DNA <213> Homo sapiens <400> 14 tgaagcccat gagccactag aagccacatg ttctgccatg tggagaagaa tgagagagta 60 catcctcaaa ttgaggtgtg gcatgatgat ttggctgccc agaggagaac ctgtctttcc 120 catctaaagt gggaggtcaa gccaagtaga gggaaacagc aactggagag cagatttgca 180 aaccagaaaa gcaactcatg aatacaaatt gcctggaaag catttattac aacagaagct 240 ctgcaagata taccggaaat tgacagtggc atcgaattcc cagcaaggaa gttttctaag 300 gacaccaaca gacaccagca gaagacagcc ttgcatttac aacaaaccat tgatccacaa 360 caaaccattg atccacactt tcaaaatcat tgaggtgaag catagagaac tggagtggag 420 acggctctgg caaatccaaa caatatcaaa agcactctca tactgaaaac ccacagtgct 480 gaaccacagc tgagatgtaa aatatttcac aaaatcttct tcaccctcta tagtatttca 540 cctgagagtg catgatttaa gttgcaagca ctgtcataga tgatgggatt cagagatgaa 600 cacatggaaa tggactttat gttctctaat gtcacaaaga aagagtgatt atgaagaaga 660 cccagattcc cacctattaa tctgagcttt gaattcttta ctttgctggg tccaccggat 720 tttttctcca ctcagcccat cgatgagagt ggaggcggcc tgcatctttt tccggcacgt 780 atcagcgtca ttaagcaaat cctgcagcca taatgggaga atgtctcaaa 830 <210> 15 <211> 383 <212> DNA <213> Homo sapiens <400> 15 ctttcaaggg cctgtgcctg tggtaactgt ctatgagcca ggtatatctg aagcatattt 60 gacaacagaa aaagttaatg taattttcaa aggaaaaacg ccaacttttt tcaaaaaggc 120 tggatccagc tcttcatgaa tgtcctcaat gagaaggggt cggcccaagg aaaggctgtc 180 ctccaagtgt gtgcgaaaat atttatggtt cagagatgtc acctaaacag aaagaactca 240 ttggtctatc tgtgttacaa agaatgtgcc cattgctaag ggaaaccgag agatttgttg 300 gacaggtaat caagaatttt aagggcaata gaagaagact tacttaaaaa aattaaagta 360 acatacaaaa attaatttct aaa 383 <210> 16 <211> 753 <212> DNA <213> Homo sapiens <400> 16 atatctgaag catatttgac aacagaaaaa gttaatgtaa ttttcaaagg aaaaacgcca 60 acttttttca aaaaggaaac agcaactgga gagcagattt gcaaaccaga aaagcaactc 120 atgaatacaa attgcctgga aagcatttat tacaacagaa gctctgcaag atataccgga 180 aattgacagt ggcatcgaat tcccagcaag gaagttttct aaggacacca acagacacca 240 gcagaagaca gccttgcatt tacaacaaac cattgatcca caacaaacca ttgatccaca 300 ctttcaaaat cattgaggtg aagcatagag aactggagtg gagacggctc tggcaaatcc 360 aaacaatatc aaaagcactc tcatactgaa aacccacagt gctgaaccac agctgagatg 420 taaaatattt cacaaaatct tcttcaccct ctatagtatt tcacctgaga gtgcatgatt 480 taagttgcaa gcactgtcat agatgatggg attcagagat gaacacatgg aaatggactt 540 tatgttctct aatgtcacaa agaaagagtg attatgaaga agacccagat tcccacctat 600 taatctgagc tttgaattct ttactttgct gggtccaccg gattttttct ccactcagcc 660 catcgatgag agtggaggcg gcctgcatct ttttccggca cgtatcagcg tcattaagca 720 aatcctgcag ccataatggg agaatgtctc aaa 753 <210> 17 <211> 13965 <212> DNA <213> Homo sapiens <400> 17 atcccctctg agaatttatc agaaaaacaa gcaataagtg agaccaacgt tgtgaggtat 60 taactcggaa ccgtcatcta tccttgtgga gaaaaacccg gaggacttgg attaggaccc 120 aatagtctac cttggcggca ggtgagaatc acctggggag cttttgaaac atgaggctgc 180 caggctggac ctcactccag accaattgaa ccagaatctc tgaggcgggg cctgggtgtt 240 ggtaattttc ctttgaaaca ctccccaggt gattctaatg gaatctagga gtgagaatca 300 ctgggggaag gcatttgtag atgggaaggc tggtggcatc tgctagaaga cttgatgtgt 360 acttggccag agataaacca caggtctggc ctgaatgggt gtggaaatgt gtcagtcatg 420 ttttcagatt tccaaggtca ttttccaaga gacctctgtg agcttggact ggatagcgca 480 gcacagggcc agcgatggca gctggaaggg tggctgccta ggaaggaggt aagctttaat 540 aactgaaata gatgctgcac tttcatctac ttaattgcta tgatttgaag tctcccatag 600 cctgaaacga ggtacccagg ggagggtgtg agagaagggg agggtactga gggatcctgg 660 ggcccctaga ccttatctca tggaaggtgc tgggctgggt cagcaggact caattgcctg 720 ctgcaaaggc ctcagtgctc cccagagatc cggctcccca cagaggcact gactgcacca 780 caccctgaga tctcactgcc ggtctacagc aggaccatta agataatcaa agagtctctg 840 gggagtttgt ggagcgtgac tgtgaccacg ggagcatatt ttattttgcc ttgaaccaaa 900 ctgctaagga agaattctct tacattttca acagaaagag ggtatcagtc agccaaatag 960 ccctgagcac acttctagtt agctaacagc atcccagaaa aatagacctg aagtttctat 1020 aagcagcctg tctccttcga gaccaaagct ttctctcagt cagggatgtt gttgggcccc 1080 atagtaaatt tggggagacc agggaaaatc caggctcagg agaggtaaat tttcactgtg 1140 cttgaatcag gagaatctga ttatcaacat caacccttct ctaaaatgaa tttaaaccaa 1200 catttaaaca tgcttcctgc cacctgcccc cactctatag aatttttcct cgactctccc 1260 caccccccta ctctctttcc ttccaacaac tccatttcaa ccacacgcac ttgatagaat 1320 atcacacaca ggcacattta ttattgacca gcttctttat ctcggatagt atgtcatgag 1380 tagtcaagac tatagctctt gaaggtagtt tcatagattt aagatgaaga aacagtatcc 1440 atatagttcc agagtcaagg tagtctaata gccagtgaaa aaatacaagc tgttggagag 1500 tggaagttta ctcatgggag ctggcttgga ctttagatat gaaacatttg atttatagtt 1560 tctatttctc tctgatagaa aactctgcta acccttattg gaaggtcgaa tgtgttgggt 1620 tctttagctg aggtagctgt taaaatttat ttcacattca aggaaagggg ctcttgttat 1680 taaccatgtt cccattttaa ttatgatttt cctggcatca tttttaacaa gaataaccta 1740 aggcctgcaa ggagtgattt cccctaatca cttcttaaac cctccctccc cacccccaac 1800 taactgctat agctacagct acacagatga aatgaaatgg agacttgagc aattacctgg 1860 tggatctgaa cagtgtggag tcagcagtca attagaatag ttcaattaca aaaatccttt 1920 tttctccctt cttcttttct gctatagaat tatcacctta actcttcctc ctccacccac 1980 cctgtgttga ggcctccttt ctcatccttc tgcttccgtt ggccccagac ccctctctac 2040 tggatggccc tggctcctct gccagcctag ccctcatatc tattcctttt tggggagagg 2100 cctcgaattc ctcctctccc aattggatgg gcttaagatg gggaaccttg tgttacgctg 2160 acccctgaac cctcacatca tttcccaggt gtcagtgtac cttcagaaag cctgtgcctg 2220 aggtcctgag ccacatcccc ctggccttcc atgttgctat tctgagattc tctttgcaca 2280 ccccgttggc tacccagatc cattcaccta cggggacact acttattctt gccagcttcc 2340 ttcaccaggg agtgagcctg accctagtcc agtatgatga gagtgcctgc ccccagacac 2400 agaagtcaca gatatgggtg ccagtaggcc ttctgagtat ggctgtacct cctgccaact 2460 ggggctccaa ggacttcctc ttcaccacag tggcaaacac ttgcctggat gttgattaca 2520 gatagatagc cagtcccatc tttggatgat tctcactgtc agccatgtct ttctccttag 2580 cagaggtctc aagcacctct cctctggcat gtcttgctgg gaatatgatc caccatacca 2640 gatatgtatt catctattca gccatttaac acgtgtttat taagcactta ctatgtacca 2700 agctttctgc tagatgctgg ggaaaacaac ttacaaaccc ttatttactc ttacatacgt 2760 attcatatgt acctttaagg aatgagtatt aatttgccag caatgcccta acaaaatacc 2820 acaaagcatg tttaaacttg gcttaaacaa caaaaaattt atttcgtcac agttctgaag 2880 gttagaagtc caaaatcaag gtattcgcag ggttgcttcc ttctgaggtc tgtgaggaag 2940 aatctgtttc agactggaac actacctttc accattaaac aaaaattcac tcaagatgga 3000 ttaaagattt aaatgtaaga cctcaaacta taaaaatcct aggaaaaaac ctaggaaata 3060 ctattctgga cattagtctt aggaaagaat ttgtgactaa gtcttcaaca gtgatcgcaa 3120 caaaaacaaa aattgacaaa tgcagaccta attaaagagc tgcatagcaa aataaattat 3180 taacagagta aacagacaac ctatagaatg ggagaaaata cttgcaaact atgcatctga 3240 caaaggtcta atatccagaa tctataagga acttaatgca acaagcaaaa aacaacccca 3300 ttaaaaagtg ggcaaaagac atgaacagac acttctcaaa agaagacata caagcagcca 3360 gcaaacataa aaaaatgctc agcatcacta atcatcagag aaaatacaaa tcaaaaccac 3420 aatgagatac catctcatac cagtcaaatg gctagtatta aaaagtaaaa acaaaacaaa 3480 acaaaacaaa cagatgctga caaggctctg gagaaaaggg aatgcttata cactgttagt 3540 gggaatataa attagatttc caccatggaa atcagtttgg agattactca aagcacttag 3600 aacagaacta ctattcaacc cagaaatctc attcctgggt atatatatcc taaagaaaat 3660 aaattattct accaaaaaga cacatgcaca tatgatacag aacatatgat gcacctatgt 3720 tctaccaaaa acaacatatg ttcatcacag cactattcac aaagcaaaga cacggaatca 3780 acctaggtgc ctatcagtgg gggattggat aaagaaaatg tggtacatat accccataga 3840 atactatgaa gccataaaaa agtgaaatcc tgtcctttgc agcaacgtgg attcagctgg 3900 aggccattat cctaagcaat ttaatgcagg aacagaaaac caagtacggc atgctctcat 3960 ttgtaagtgg gagctaaaca atgggtgcat agggacataa atatggcaac aacagacact 4020 ggggactact agagggagga gggaggagca ggacaaggac aagggttgaa aaactacctg 4080 ttgggtaccc acagtgtcac acaatatatg catgtaacaa acctgtacat gtactccctg 4140 aatctaaaaa gttgaaatta tatatataaa atgaaagtat agaataaatt aataatataa 4200 tccactgtat aaaaaaaaaa gaaaaaaatc tgtttcaggt tcctcttcta ggattgctga 4260 tgaccatctt ctccctgtgt ctcttcacgt catctcccct ctatgcattt ctttgtctgt 4320 gtccaaattc tcactttttt ataaggacac cagtcatact ggattaggag cccaccctac 4380 ttgtgacctt aacttagtga attacatctg tactgatctt atttccagat aaggccacat 4440 tctgaggtac tgggggttat atcatttttg ggggacacac attgttcaac ccataacagt 4500 atgcatcatt ttatggggca gtaatgatag agatgtatat gtacagtgca gacctagtaa 4560 agggagtaga cacttttttt ttttcagggc agacacatcc tcaagaaagc taatatgaag 4620 ccacaactat gtttcaggaa ctatttttgt ttattgatca cttattatgt gctaaacacc 4680 atttagtaat ttacgtgtgt caacacaatc ctatgaagaa gctgagccac agagaggtta 4740 agtaaacagt cccaatgcac ataggaaggg gcagagtggc agatcaggtg tattttgcag 4800 gaactgaatt acttatactg tcttccccta cctccctgaa acaccaggct ctgcccattg 4860 aggatctgtc catagtttaa gaccctggcc ctgacaggga ccagcttaca tggatgatta 4920 ggcgtgaaag ctgtctgagt caggcaaagc agaagcctca ttgtgccaaa cttcctaatc 4980 cccttggtca gaacctctgt ccccatgcac ccttaaaata ggcactttcc agtctatttc 5040 aggtgctgtt tattgtcttc ttggtatctt tcaaacacga ttatcatatt catttggtta 5100 tctctagagt gtaagcccca tgaagggagg gacttgtgtt gtcttcttta gtgctgcatt 5160 gccagtgcct agcaatggcc cagagaggca ttccagaaag acttctggta aatggattgt 5220 gctatatatc agatttcttt ggggtcttct cagaaattag acttcattaa aaaaataagc 5280 cctaggtgaa aaatgcctct acgaacttgt acattaaatt actgagtaaa aatgaggcac 5340 ttaaagcatc acagctggtc tctagcccag gcatggaggc cactgaagat gtggctgtct 5400 gcaccaaagt catattactg aattcattga taattatcct aagtggagca aatagccctc 5460 atacaactct tgagcatagc tgtaagtttt attttcactt aaagtattga cttcccatcc 5520 agggatccat catccttttt tttttttttt tttttttttt gtaacagtgg cccactccca 5580 ttgctttgtg gaaacaggcc acgcgttcaa ggcaaacttg actgtacaga gctcacagtg 5640 gggtgggtac ttcacggaca ctctctgaac tgctaaggtg gtagagcaaa gcaggtggag 5700 ttgggagttg gaaggcctgt gtgctcaccc tggcccacag gcagctcata atttatgttg 5760 agattgggta tcccacttgt aagaaggagt aaataatttc tgccctgttt gcctcacata 5820 ctattgcagg gttcaattaa gttaatgcac agaaaagcac ttcggactca gaatttacat 5880 atgtaaagaa taattacctg ggagcaacgt ggcaagaaca ggagtggtgg catctgatag 5940 acctgggctt aaatcccagt tctactcacc ctgctgtgac tttagttatc tataaatctc 6000 tttgattttt tgtcatttgt tttatcatct gtaaaatggg gagaacaata ccagccttgc 6060 atgattatga gagtcaaagg gaataatatt tggaaagttc ttggcacata gtaggtgcag 6120 tggtaacttt tttgctgctc attttagttt gtcacttaat cagagagtgt cattgtatta 6180 gttttctgtt attgccataa actatcacac acttagccac ttaaaacaat acaaatttat 6240 catcatgtat ttataggtca gaagtccagt gggcttggct ggtttctctg gccaggtctc 6300 acaaagttga aatcaaggtg ttggcaggcc caggggatta tctactttca gacttattca 6360 aggcattggt agagttgagt tccatgtgat tgtagaattg aggtctccca gctggtggct 6420 ggggattgtt ttctgtttat agagaccacc cacactactt ggcttgtggt ctcttccccc 6480 ttcttaaaag ccagcaatgg tgggttttgt ccttctcatt ctttgaatgt ctcctctgtt 6540 tcccttttct gctgcagctg actcttctgt ctcctctacc cctttaaggg ccccatgatt 6600 atgttgtgtg taatttcatc tgcaaagcca cgtaagcata ttgtgccaag gtaacacatt 6660 cacaaattcc aggggataaa aacatgaaca tcttttgctg ggggtggggt ggagcgggat 6720 tattttttct accacaacca tatgttgata tccgatgttc tcatattatt aataatgtct 6780 cctcaacaag atctaatatt caaagtactt agctcaatgc ctggcgtaga gtaagcgctt 6840 ggccaatatt agtttctatt tttgttgttg gtaagcagat gacaataagt atcttgtttt 6900 tttctacagg ttctagcaaa tccacctggc taagggatgc atcttccttt actactcatt 6960 gtcaattctc tccagaaagt ctttctgacc ccagtccttg cccaccaggc tggattcagt 7020 gccagtcctc tgtgttacag catcatagaa cttcccttgt tcagctgtcc attaccctat 7080 aactctttca ccagattgtg ctttttgagt acagaaactg acatttctgt atcatttagt 7140 agagtgtctg gtacatagta catgctcaag aaatgcttat tgaataaatg aatgatggga 7200 aaatttatta tatacttaaa aatttttgat caaataatta ctggttggaa agtatccctt 7260 aaacaacaca aatattgaaa tattcagtga gaggaaaatc tatgcatatc aatactgtgc 7320 ttcctgagaa ttatctttac acagaagact tcttgaaaaa taaataaaca ttgtgtttgt 7380 gaattgtcca ggcctggatc ttgaggagga aggcacttct gaaatagctg caactcccgg 7440 taagtattgt acttggaatt cactgaatga ttgtgacact ttttttttct gaatgcatta 7500 gggaacaaac aaagagagta ttgaaataaa gccacatcat cttggcttct catttgcttc 7560 cttactggga cttattatat ctaacagcaa aactgaaccc tagtgttatt tctcttggaa 7620 attcacgagg agctcttcct tctgtttttt tttttttttt ttttgtctca cacattgaat 7680 actcattttc tgtccatttt gtgaagtgtc ttaacaatac tgcaagtagt tagtgaccaa 7740 taataatcaa ataagagcaa ttttcatagg gccattaata ttgccatgtg tgttttccat 7800 attttagaag tttctcaatt ttggtttgtc agcctgccca tgtgattcca gatcagccaa 7860 ggaggccagg ctcctcttgc ttgggccagg atcacttaac agctgttttg agcttggctg 7920 gtctttttgc aataattgct cccactaagg gactttgatc ttttgatatt tatttttaga 7980 tacaatatag tcaccattat tttaaaggaa cagttttatt atctgaaaca aacaaccaca 8040 aatgaaaaat tggagccaaa tcacaggcct caggacccag atgaggaata aagaaaaatt 8100 gtttatagcc ataaatgctt tctttgcagc tttccttctg tctattgggc tgggtcacat 8160 tttctaccat cacagaatgg tgattagaca tcagattata tcttgatatt acaatggtac 8220 tgccctctat tggaagtctg ggaatcctaa tttcctttgg attcagtgct ccattttgaa 8280 atcacagtcc agctcaggta gcaggctcac atataacatc gaagggttgc aatgaagtaa 8340 tttctcaatg gctcctctgg ttgaacatgc ttgcacaatt attttaaact cagcaaacat 8400 ttgttgaaca cctatgatgt gccagacatt gtgcaaggaa ctcaatagat gcagagatgt 8460 ctaaaacacg gttcgtgatt tcaagaatct tatgacctgg tacaggagac agacttttat 8520 ataaataaat agaaaggaat ctgacttcat ggagttctgc aattccaagg aattttaagt 8580 ggtatgtggg cagatgcatg gccaaggaga attaggactt actactggac cagtcattgg 8640 ctcagtgcct ggcatacggt agatacttca taagtggggt atgcatgatt tggagaaggt 8700 gatgtaatta ggacggaggg gtctggaagg gctgtacagg aagggatgca gccagagcct 8760 cactgacatc ttcctctcct gctcatactc tgagcaatcc tagaaccatg gtggatgact 8820 ttagctgcag cacagtacga gaacagagtg atcaggagtg atgcactgac agagcatcca 8880 gcaaggcctc tttcattaat aaactattaa taaacacaac agactgatgt gccacacata 8940 gcagtactat ttgagcctga atatgcctat agggcagcac accttgagtg gacagtgggt 9000 gctaaagagc catttataca agtaatgtca ctctcttgcc tgtcctagag ttcttgctcc 9060 attgtaacct ctcttgagga attcactcct ccactgagtc tctgaaaaaa gaaaagcttt 9120 atctatcaat gagcaagctc tatagcaggg tttataggcc ttccttgacc tgggccctga 9180 ctaccatctc tatctcctct cccagaactc tcccaccttc ctccaaccga tccaagctgt 9240 tattagtttc ttctcacact ttcatgcctt tgcactgcct ttccctctaa ttggaatagt 9300 ctagttttta atctaaagtt tctacttatt ctttaagact tagctcaaag gccacttttt 9360 tttggaaagc atttctttgc ttttttagac tacaaaaaca tcttctgaat ctccataaca 9420 ctaggtcatg tgtctgtcct actgcttact gcaattctcc aactatttgg ttatatatct 9480 gtttccctag aggtcaaata cggtgtccta ttagtcattt tagccccagg gggttaatat 9540 attatctgga acatagctaa cattttgtga atacttttct aataaacgaa gtggatttgg 9600 caaaaaactc tgtgttaaga aaggtctagt gaaatatttt tcatctttca tttataagta 9660 tctataaggt aagataggcc cattgtccac aatctgcatt aatagatctc aataactggc 9720 aaaggaagaa tgctccccag agaccaggag agagaaaagg ccaagtgggc aaagccaggg 9780 ccctctttaa cagacaggga ggacagaaag gatgggaacc cttgttcata actgttcctg 9840 tgaaatatcc cacaaaaagg aatctgtgct agaattattt tgggaaatgc gatttactct 9900 tttctatttc attatttact catcctatta tttaacaagt atattttaaa tgtctactat 9960 ttgccataca ttgttctcag cactggaaag atggcagtga acagcatagg tcatggttcc 10020 tgccctccca gagtttacat tctagtgtga gacacaagcc ataaacaaaa taagaacttg 10080 aactgggcag tgttttacag aggggtatta agtgctatgg agaaaagaag tgggaaagct 10140 tttattggaa gtggtgggga gtggagtatg ggaattttga ataagaggtc aaggaagttc 10200 tcaccaaaag gttgcatctg agtaaagacc tgaaagaaga gaaggagtga ggtaggtgga 10260 tgtctggcta aagagcaatc aggaaagaag gagctgtgaa agttccatgt ttagaggaac 10320 agcacagggc ccagtgtatt ttcagcccag gaagggaggg aggtgaagat gggagatgta 10380 ggtggagaag tcatagaaga gcaatcattt ggggttgtag gtaagaactc tggatttcat 10440 ctgagtaaaa ggggaaagcc attgcaaggt tttgaagaaa gaggtgatat tacctgttgt 10500 ggcaagtgag gcagtcaacc taggtgttgg gctgagagta gactatcggt gaagggcaga 10560 ggcagggaca ccatttggaa ggcttcttaa atggtccagg tgagggaaga tggtggcttg 10620 ggccagggta gtggagtaaa gtggtcaaat tctggatata ttttgcatgt agaatggata 10680 ggatttgctg atggatgaaa caggaggcga agaagaaata gaggaatcaa gaatgacatt 10740 aagatttttg gcctgagtaa cttgaagaat gaagttgaca tgaactcgtg gtgggggaag 10800 actgagtgag gaggagttga ggggatatca agttaagttt cagacgttta ttagacatct 10860 cgtggaagac catgaatagg cagtcaagca atcagaggac aggtatgggc aggagatgta 10920 aattgaacag tccttatcat gaagacagta tttaaagcca ggagactagg agaggtcacc 10980 cagagtatga aagtaggcca ggaagagaag agaagagaag agaaccaaga actgaactct 11040 gagatggatt tagagtccca gctcttgaat tctcatctct gacagtcctt gaagaaaaga 11100 aacaggttta acttggcttt tcccaatgta tcggatgatg gaacaccctt tcccctatag 11160 aactgtggaa tttatgttcc actgaacact ttttggagaa ggccactcta ggcttggaag 11220 ttatcctagg gccataaggg aaagcctttt ttatcctcta ctaagaagtt tggactttgt 11280 ctcccaggtg ttggtagttc accagtgaat tttttttttc ttcaacacaa gaatagtggt 11340 gttctttatt tacctttgca tatttttttt cttctctgaa tttttttatt atactttaag 11400 ttctggggta catgtgcaga atgtgcagtt ttgttacata ggtatacacg tgccatagtg 11460 gtttgctgca cccatcaacc catcatctac attaggtgtt tctcctaatg ctgtccctcc 11520 cctagccccc aaccccccaa caggccccca gtgtgtgatg ttcccctccc tgtgtccata 11580 tgttctcatt tttcaactcc cacttacgag tgagagcatg tgatgtttgg ttttctgttc 11640 atggatggat tttaagagaa gtaacaggat ttacatattt tggtggcagt atggaaagtg 11700 gcttgtagag gggagtctga tggaataaga caagagaata gctgactgca gtagccttgg 11760 tgacagatga tgaagccctg aacatagcga ctaggaatgg atggaagaat cagattaaat 11820 gggtatttag gatgtttaga atcattaaca tttgatgacc aattagatat agtggatgat 11880 gaaaaatatt caatgataat cctgagagtt ctgtcttggg tcagattgtc tatatttacc 11940 tgtatccctt agagagatct atcaatgcaa ggtacaaagc aacattccat gtaattagct 12000 tttattttta actctgttca agttatattt taacagagga aattgtgaat tgatttaatg 12060 cccaatgttg ccttctattt ttgtcattca taaagccatg ttagtttttt tattaataca 12120 aaaatacttt aaaatggtat ttacttgagt aagcatgatg aatcgtttga atgtgcagag 12180 gattatgatg ttatttttta aacactaata gtcatatttt gggattggtg tgttctaatc 12240 ttttacatgc agagtacaga attaaaaaga aaacagatta tactgactag aaaagtgttt 12300 ctagaaggtg gtttaaggac cttgtataga ttgggccttg ttctccaaca ctgggaaaag 12360 gtgggagaaa tttccaacat tgcttcattg cttatctgga tttttgtatg tttagaatgg 12420 gactaagaaa tgctggaatt tctctgaata ctccaaggac tctggaagga aagtacattt 12480 ctataatgtg gctgtggtat gtgcacacct tttgcctttt aaaacagcct tttgccggca 12540 ttaatggcat ctcctgaata tcttgggttt gaagctgtga attgagaagc agaatcaaat 12600 tgtttagggt catgtgaata tcacatcttt actactaata aagcacagag gaaagacctt 12660 cagttggaca tttaaataat tcctaagaca aaatcaatgc ttttttggta gtaagtattt 12720 gtcctattca caattttttt tcttgttttc tttcctctag gcacattgta gggttgaact 12780 tccctgtttg cattacatag gactggtcat ctgactggct gtggccagtg aaaatgtaga 12840 tgaaaatagc ctgtatcacc tctggacgag tcattaggag tcagtgtatg atttgataca 12900 tttccttctc tctgccatgg tgattggtga tggaggctct attagttttt gttcctgagt 12960 aaagtaatgt gggtatgagt ccctagctga cttccaatac gagtgagaaa taaaccttaa 13020 ttgttttaag cctccaagct ttggagtttg ttgtacagcc caccatgaca aatatacttt 13080 tagtccttta tttacatgct ttaaaatact gcttgcattt tctgattacc atatgttcat 13140 tgtggagaat ttcaaaaaat ataaaaaaaa acctttgaaa tcacttacat agaaatagtc 13200 tctgttaata ttttgatgta ttgtcttcct ctcccaattt aaaaaatcag gatcctaata 13260 tatacgatat tgattttttc acttcatata tactcttaaa atacatgaat ttgctgcata 13320 ttattaattg atgaggaagt gttataatct atttttatat ttatgtttta tatttatact 13380 atacaattca taagagtcac attttatttt tgtacttttt cttgttgtaa ataacattcc 13440 aatgaaactt ttgtgattaa gtctttgctc aaattgctgc tgctgtcctt ggagtagatc 13500 cctagaaggt gaacgactag gtcaaggagt atgcatactt ttaagatttt tgctacctat 13560 tgccaggaga aaggttatac caattaacac gtcagctgtg tgagatgggc catctcacca 13620 gtctgttgag tattagaatt ccttttaatc tttgttaatt tgataggtga aaacgctatc 13680 ttgttttata tttgcatttc tttgattaca agtgttgttg aacatttatt tcgtatgttt 13740 atgagtcatt tgcacttttt tcttgtggga attatctaaa tggattctca caccccccaa 13800 acaacaagct aataaacgga aagccacaca ggaagccggc agtactgttg ccacggagcc 13860 tctgcacgag cttttgaagt gtcagcgttg aacaggttcc tctaactccc tctcatctgc 13920 cttgttttga ttattttctc tccagctgta tccctccaca gtcca 13965 <210> 18 <211> 2218 <212> DNA <213> Homo sapiens <400> 18 ttctttttgt ttgctgcctt ccgtagaaga tgtggcttgc tcatgcttga cttctgccat 60 ggttgtgagg cctccccagc catgtggaac tgttttcagg tgctggttcc atggctcttc 120 ctgagccgaa aataaggaaa ctccatagac cttgtccact ggaactcgtt cccatctacc 180 ctccactcta tccagggtga tggatctctg cagtaagtgg aagagttctt catggccccc 240 aaggttatat ccatctagaa cttcagcacg taatttcatc tggaaatagt gcctttgcgg 300 atataagtta ggtaaaactg aagatgagat catactggat taggatggga tctaaatcca 360 atgaaaatgt cttcataaaa aacaggaaag aacccataga aacacaagga agaaggtcat 420 gtgaagatgg aggcagagat tggagggatg cagccaccgg cccaggaatg ccagcagcca 480 cccagaagct ggaaggaaat gagggattct ctcctagaac ctttagagag aacatggtcc 540 tgtgaacagc ttgattttgg acttgcccat agcttgtata ctcttacttt ggatacaatt 600 ttatccaaac ttggctaaac agtttctcag cctatggaaa atttaaaatg gagaagattc 660 aactcgattc ttacagattc aaagcaagaa aatgatggga acataggagg agaccaagaa 720 agcctataaa aagcaaaaat atgaagtgaa cattgtggta gctttaagat gtttagtgta 780 gctgcaggca ccctatacac atgaaaaccc ccaaggggaa tccccatatc acagtgtagt 840 gtgatatttg acattcgtga tcatctagag atgtacagaa aaggtgaatc tgtgttctgt 900 atattctgcc taaggcaaag aaatgtttag ctctctttaa aatagttcca taattttttc 960 taaaaagctt tgcttgaaaa ctgtaagctt cccatatctg gagcatttca ctttaaatat 1020 ttggataaat atgttatctt cttacttgga catttcatgt gtttagggat tgtcttctaa 1080 attcttccta attcatatag ctgctaacac ttcccgcaga gctaaaccat tacagatatg 1140 aaataaagac ctattgattt gacttacttt tacttgtaaa accttctgag tgttataacc 1200 tcatttaatc tttcagcatt tacagtttca agagtttgtg tcacaattag aagaattcag 1260 ctgcacctcc aagtgacagc agttgctctg gttggtgggt gatctcagga ggcttgagaa 1320 ttgctttgtc tgtgagggaa gtaagacatt ttcagagccc cactttagaa ggtgtgaact 1380 ggctagataa tgaaccccag ggctaacgct gctatagcag tgggaaggag gtgatgggtt 1440 ttcagtttgg acctcaaaca tcaataccct cctggtacgg ggaggaacag agtccctcct 1500 ttacttctcc attagaaaga atgagatggc aagacaatga aacaggcaaa gtgaacagag 1560 atgcaagaca aaattcaggt gagagagcca gagcatcact cagccattcc tgacatgtaa 1620 aacaggcaac tagaaatttg cagaaaggaa gcgaagtctc cataaagatg tttttaaagt 1680 gagcttgaag tatttggaga caattcagtg ttacataaaa tctgcaaatc tctggataaa 1740 gaagcagaga tcccagcatg ggacaaatgg agcctcaaaa gtgggaagaa gacagagaag 1800 accagggcag aatgcatctc ttcctttctc ttggctttcc tggataagga ctgcatcatt 1860 cctgtggaag gacaggccat cagctccgaa acactgtatg tattttccag tatatactgc 1920 tagctgtgtg atgttgggaa aatttgttac cctgtctaac ccccacttcc ctcatctgta 1980 aaatggaaat aatgatagta cctacctatc tcataggtgg caactacaag gggcagcaca 2040 ctcagggaat taaggaagtt tcagtgaaca tcaactttat gaacacagtg ttcataaagg 2100 caggtcagtg cagtggtttg ggagccagga gaagcacgtg ggccggagtg tgcctgcagg 2160 agacaaggtc agagatgttg ctaataatgg agaataaagg atgcattctc attactga 2218 <210> 19 <211> 465 <212> DNA <213> Homo sapiens <400> 19 aggggtttcc gcttttgctt cttcctcatt ttctcttgct gctgccattt tcgcctcccg 60 ccatgattct gaggcctccc cagctatgtg gaactgtaag tccagttaaa cctcgttttc 120 ttcccagtct cagggtgatg gatctctgca gtaagtggaa gagttcttca tggcccccaa 180 ggttatatcc atctagaact tcagcacgta atttcatctg gaaatagtgc ctttgcggat 240 ataagttagg taaaactgaa gatgagatca tactggatta ggatgggatc taaatccaat 300 gaaaatgtct tcataaaaaa caggaaagaa cccatagaaa cacaaggaag aaggtcatgt 360 gaagatggag gcagagattg gagggatgca gccaccggcc caggaatgcc agcagccacc 420 cagaagctgg aaggaaatga gggattctct cctagaacct ttaga 465 <210> 20 <211> 555 <212> DNA <213> Homo sapiens <400> 20 aaaagactat ctcttcccat tgaattaaat tggaactttg gaatcttaat agaaaaccaa 60 ctgacttggc ttggttttca ggtgctggtt ccatggctct tcctgagccg aaaataagga 120 aactccatag accttgtcca ctggaactcg ttcccatcta ccctccactc tatccagccc 180 catgaggaca aggaacatga ttggttttgc tcactgccgt atcttccgta cctagtacgt 240 aacaggacat caataaatat tagttgaatg gaagattaaa tcaacaaaat gggtgatgga 300 tctctgcagt aagtggaaga gttcttcatg gcccccaagg ttatatccat ctagaacttc 360 agcacgtaat ttcatctgga aatagtgcct ttgcggatat aagttaggta aaactgaaga 420 tgagatcata ctggattagg atgggatcta aatccaatga aaatgtcttc ataaaaaaca 480 ggaaagaacc catagaaaca caaggaagaa ggtcatgtga agatggaggc agagattgga 540 gggatgcagc caccg 555 <210> 21 <211> 501 <212> DNA <213> Homo sapiens <400> 21 cttgctcatg cttgacttct gccatggttg tgaggcctcc ccagccatgt ggaactgttt 60 tcaggtgctg gttccatggc tcttcctgag ccgaaaataa ggaaactcca tagaccttgt 120 ccactggaac tcgttcccat ctaccctcca ctctatccag ccccatgagg acaaggaaca 180 tgattggttt tgctcactgc cgtatcttcc gtacctagta cgtaacagga catcaataaa 240 tattagttga atggaagatt aaatcaacaa aatgggtgat ggatctctgc agtaagtgga 300 agagttcttc atggccccca aggttatatc catctagaac ttcagcacgt aatttcatct 360 ggaaatagtg cctttgcgga tataagttag gtaaaactga agatgagatc atactggatt 420 aggatgggat ctaaatccaa tgaaaatgtc ttcataaaaa acaggaaaga acccatagaa 480 acacaaggaa gaaggtcatg t 501 <210> 22 <211> 10817 <212> DNA <213> Homo sapiens <400> 22 ctctttctct ccttctccct tccttcctcc ctccctccct ctcttcctct cttttctttc 60 tttctttctc tttctttctt tctttctttc tttctttctt tctttctttc ttttcttcct 120 ttctctctct ctctctttct tttcttttct ttgctttcct ttccttttct tttccttttt 180 tctttccttc ccctacgtgg caaatccagg gttgggctag ccaagaaaag tagtaactta 240 gcaggtctac cactgacccc taggagatcc aaatatgtta ttttatatat ctttaagtac 300 agggatcact tgcaaaaact atcctgatat tattaacttt tatggagaaa tcctaacaca 360 agtctatttt acaataaggt gttgtatatc acatgtaatt tattgactac tgcagtgaaa 420 gtgaaaaact gaatggctgt gtgaatactc aaagtatggt ttctactgag catgtatcac 480 tttcacatca ttgtaaagct gaaaaatcac taagttaaac catcataagc tggggactgt 540 ctgtatattc tcattgaata gttttattgt attactattt tataaaacta atatattttt 600 ctccaaataa gtgactttac aaagatgaat tttgcattcc aaagtatgtt atatgtttta 660 tttattagca aaagtatgaa ctttggagtc aggtagattt gaattaaatt ccaattatac 720 tagaaagctc tatgactttg gtcagttata gtaagaattc ccaatttata gtaattttat 780 aagcataatt tttggcactt agaaaatgct caataaatat tgattctttg tgatatgatg 840 ataattaatg atacctataa taacaaaggt gacgatggtg agagactaca cttctctctt 900 ccatttacct tcagttataa tgaaaggtaa tgagtaaata tgactaagta gtgaatatat 960 ataaagtatc agaaatattt ctatttaata caatgcatca aatggtatag tacatatatt 1020 ttatctgaaa taaaagcctg aagtgaacaa tttggcccta accatataat ttaaactaat 1080 cactattttg taatttttac taatttagat gttgtagaag gcaacatatt tctgagaatt 1140 ttttcttttg atttaagaaa aatgctaaca tgagaaaaat aattcttact tgattttaat 1200 gatttaatta taattttttg ataacttttt tatctaagat gtgagcagct atgttttact 1260 cttagttttg aattctttgt tagtttccta tttacatagt tggctttctt atattatact 1320 aatatttata atcatatact gcagagattg ggatggactc aagtactcca aattttacag 1380 gaatgaagtc tctcccattt tggtaaaatg gcttttgatt gttatttaat acaattcaca 1440 cttgctggga tttagaagtt ttgaaatcct catttcagtg acttctataa gtttttcaac 1500 tgatgcccaa agattagtgt tcctttgcct ccattcattt aaccaaggtg tagaacaggg 1560 taggccagag ctgaaggaaa gacagcgctg gagatgatgc tctgaatggt gcttgctgga 1620 gccacagata atctgaggat gctgcctttc ctgcttccca ggagctgagc tagtggaaaa 1680 aagggaataa gaatgtaatt tttcttcaga tttaaaatgt ctgataacaa aagttgatta 1740 ccctgtttta tttggagaga aatccaggtg tagagaagat attatacttc tctttgagac 1800 taagtacctt taaaatagtt ttagatatct ggatttaatt ccatatgttt caatttttct 1860 atatttatat gatagataca tttaaataaa gcatgctcct ctatatttcg ctcaggattt 1920 tggacagagc tgataaattc tttcactcat ttactcaaca tacctttatt aaatgcttac 1980 ttctgcaggt atttatactt aaaatcataa tttacttcat aaaatttaaa atctaacttt 2040 tggagtcctc aaattgatat ggtcttatcc atttattggt aaaatgctgc attcgataca 2100 acatacaaag tggatgcctg tggcagagca gttacttgcc attgtctctt tttttttgtt 2160 ttctctccca gaggaaactt caggtttggg ctgtttcatt cagacccctt atgaccaggg 2220 tgtacatttc ccagactaca tgtatgaaac tcatggccat ggaatagaac aaacacagtt 2280 gctccataaa gtctttttaa atacggtgtt ccaaccaact gagctaaaca atctcagact 2340 ttgaaaagaa tatgttcttt gcttagaaga ggagcaaact caacagattt aacaaatttt 2400 aatatctcac agatttaaaa aacaaagaat ttcaaggtta accgggaaac tacaatattt 2460 ttcttgaggc tgtttaatct gagcctgcac ttcagaagcg attttatgtt ttaaatttta 2520 gggttctgac ctgttttcct ttctcaaaac aaacatgcta agagtttaaa atcaaccatg 2580 atcattgcta gtaaatatgc actcagacct gacctggctg tgcaaataaa gtccattctc 2640 catggtgatc agaagcagca atgtctcact atggaaggtg gctagctgca tttacagact 2700 gtacaatcta attcctcctt ctgtaaatgt tgattaagct gaaagaggat cgttggcaaa 2760 gctaattcaa tagcaccgtc tcctctcctg aaaggctgga ggatgatctc actatcacat 2820 gagtccatta gctatccctg cagcaaaact caccatctgg ctaactggct tagactgtgc 2880 tgattggact gcaggctttt ctagcactct cttgtgatgg tgagtgtgag agtaagaagc 2940 tgggaggggc agctggacaa cataagactg ctgttatctc ttagggagct aggtgaaccc 3000 taagtgctgc ctgatagcaa caggacctgc ctggcactga ttgtctattt cttagcattg 3060 gtaacagaag acatggtcat ttatgatcaa tatgatggag ttgacaaatt aaacaaacaa 3120 acaagcaaac tcttccttct aaccctgcaa tctttgactt ttgatcctgt cattagataa 3180 ctgatgtagg aaagtcactg aagcatcact ttaagtagca gtggatgaag cattttcaaa 3240 ataacaaccg gcctaagtca aaaatcaaat cgatgtttgc tccattattg ttctcttatg 3300 tcagttctga tggtagttcc tgttttagcc tctcttggaa ttatagagtt agaattgtga 3360 ctgaataatt gggaataaga gggaaaattg agtattctgc tgcctttgtt gaatctcact 3420 ccgggttaat tgctgctaat tatgcagctg cttattggtg catttctatc cacttctgcg 3480 tctgaacaca gaaggaagac gtagggagga tccaaagtga gactccaaca aaacagctga 3540 tcataacctg catgtaaaat tgagaatttg ttttcttttg cttttatttt acattttttt 3600 taaaattatg gttcaataac agaatataat cggttatcaa aagcaatgac attctgttgt 3660 cagcatctga gagttgttgg tatgatcact gttgggtgga atgtttaagt attattccta 3720 cagcaaataa gaaaagtgac tctaattact gaagatatga aataaaagat atgaaaagca 3780 agattgagaa agaccttctt tactggtcct tattagtgtt aaaaaaggcc acactaacaa 3840 atcagggact gaatatcatg ttgttcagcc atataggttt tgaatgccat gtggtggtta 3900 gcttactttg acaggagcag tacagtctta ctcgtttggc aaaataacaa atgttcccat 3960 tattttggat tatatattta tttatgtgat tttgcatatc aagtgcacaa aaattaagct 4020 tatggtaaaa aaagtaccat taattagtga ctctactgta attgaatcag tggtcattgt 4080 aatgtacctt aaagtcacta tggagtttta agacattaat ttacaacaag aagagaaaag 4140 gactaggaac ataaacatgt ctgcacatag atggggaggg gaggctaaat tgagtgaatc 4200 cctccaattt tttcactttc tcctcactct gaccttactc caacatggcc tcaggctcta 4260 gatttctacc agatcacatt acagaggcat gtgatgagaa ggaaccactt gagtcttttt 4320 tttttttcca gaaccaagcc aagtaattca gtcatgcaaa agtttacgca attgacaata 4380 ttcactcatg tccccctgtt tacaatttta aggtgtgtaa aggccagtca caagcaagga 4440 cggtcagcat tgctttggtg tagatggaac acacggagac gatggaactg cagggcgctc 4500 acagacagat agttgaccaa gagtgaaggg cagtagctaa aactgagtgc ctataaggtc 4560 aaggaatgtg acataaaaga gatctgtgga tgtggcacaa ccagtcaagg ccaattttgg 4620 ggaagatgta aattttaaat gaggtttcat aggaagattg gcgatctaag tagggaaaaa 4680 tgttttccta aagcgaataa gcatggcgtg acaactatat gttgtgttat aagtttttct 4740 attcacgaac ttttcttttc ttttcttttt tattcttctg ttatacagaa gttcccaacc 4800 tccaagccat gaactagaac tagtctgtgg cttgtgggga actgggctgc acagcaggca 4860 gcgagcaggt gagtgagcag agattatggc ctgagctctg cctcctgtca gatcagtggc 4920 agcatgagat tctcatagga gcccaaatcg tattgtgagc tacgcatgcg agggatctag 4980 gttgcgtgct acttttgaga atctaactaa tgcctgatga cctgaagtgg aacaatttca 5040 tcctaaaact gccttcccac aactggccca tggaaaaatt atcttccaca aaactggtcc 5100 ctgatgccaa aaagattggg gactgctgct gtcatataag gataattatc ctcattttac 5160 agaggaggaa attgaaagtc agatgtacag tgactaaaat agctaaaagt gatgaaaatt 5220 agagctgagg tgttggtcct tacagacctt ctacttctgt tgcaccccag ggctctgtcc 5280 tggtaacata caaacagagg cagtgccaac actggagggt ggaaggctca ggccttcatt 5340 ctgaccccaa ggcacccagt accttccata gtgcttgctg tcatccctac tactattgtc 5400 tgctcactac ttctctactg gtcacagaga aagccataaa aagatgtttt catactcatg 5460 agttccccca tgcaggcact gatagaactt gataagttga ttcatgctct gtagttctct 5520 tcacagcaag cagctcgtct ccctctcagc tttcaccttc aacgccctgc acagcaagcc 5580 tgtggcagct ctgctcctca gctgtcagac aaaaggggag aacaaagcaa gactgtgatg 5640 caatactcat gttaggtaaa tctttcccca gctagtactt tctgtcctgg gattattttg 5700 tgaacacaga tttcgttaga gagcaattga tctgaacatc tgggggctca ttagctcctt 5760 ctaattgcta taatgtggtt ccattctgat ttcatgcaag gggtgcagtc ttcatgcaca 5820 aactattgat taattacaca tttaaggcat ttgagaatat cagctgagtg catttgtggt 5880 ttcctaggat ttctccttta ttttccctgt ctgaactttt ccttgttcct tcgcctcccc 5940 cttacctctt gccatgccaa tcagtctcta aagcattcac tttataaaca gaaagtcaaa 6000 atggtgcttt actatttatc tggtaactca tattggaatt tggaagagtg gctgatgtga 6060 acaatggctc ataagaacat taatttttct tctgtactga atagtctcat tgaaacagat 6120 ttggatatga ggatgatgct tacataataa atacccaagc tggttgggtt agcagattgt 6180 ttacatgtgg gcacatgtgt gtggcttgtt gctgcatggt tgcccattcc accgggagaa 6240 gctctgttgt tatgtgtgtt atgaaatttc aaataaggga agaacaacag ctgtaatggg 6300 cccaatccaa tgatggcaaa aggtgaataa aattactccc tctgggaagt aaaatgctca 6360 tttagtggag ggaaattatc atttccaagt agaacatttg gcttcctgag agtgaaagtg 6420 tcggcacagc ttgataataa cacctcaggc tgtaatagta ccctttcccc tctgagagct 6480 aggctttttc cctctaaatt tatctctaca acgtctttgc aaagtgagta ggcacagttg 6540 ttattggcca tattttatag atagagaaac tgagagtcta aaaaactcag tgatttgtcc 6600 ttggaagccc agaaatcaat ctagataagg gtttctcagc cttggtgcca ctgatatttt 6660 tgaaccggta attcttggct gtggtggttg tcctgtgcac tgcagaatat tagcagcatc 6720 cactagatgc cagtaatgcc cccagttgtg actaccaaag atgtctccag acactgtcag 6780 atgtcccttg ggaggcaaaa tcacccacag ttcagaaaca gtgatctaga ttggtgggcc 6840 cggacggtct tgtagccttt aggaaacctg aagcaaaatt tggaaaaata aaaatttgcc 6900 cttgacatcc atagtttctc ccatctgtaa taacagtaca tatgtaggat tcattattat 6960 gaagtcttta cacttgtcct gcattattca tggctttaca tcctgcattt tcagttaccg 7020 ttggtcaacc aaagtctgaa aataataaat ggaaaattct agaaataaaa attcataaga 7080 tttaaattgc ctgtcatcat gagtagtgtg atgaattctc aagtgtcctg cttcatctct 7140 cctgggatgt gaattcttcc ttgtccagga tatccacact gtctaggctc cccgtttgtt 7200 catcacttaa tcattgtgtt cgtcatcaga tcaactgtaa tggtattgca gtgctggtgc 7260 caagtaaccc tgattttact taataatggc cccaaagctc aagatcagtg atgcttacag 7320 ttcagatatg ccaaggagaa gctctaaagt gcttccttta agtgaaaaat tgaaagttct 7380 tgatttaata agggaaggaa aacaatcata tattgagatt actaagatct atggtaagaa 7440 tgaatcttct ctctatgaaa ttgtgagaaa aaaacaaaag gatgtgtata tagtatctat 7500 aaagttcagt actatcctca gtttcaggca tccactgggg ttcttggaac atatcccatt 7560 tggataagga gagactactg aatatacctt aacttcaatt ctattttaat cacatttttc 7620 acataggaaa acagaaccac aaaaaggtta gctcacttgt tcaaatttat acagctagga 7680 atcagggttg gcttcatgag cattttgacc taagcagcta cacaggatcc catgtttaga 7740 agggtgtcat acttggttta atgatcttgc tgtccttata ttgaaactat taattatttt 7800 tgaacaagag tttcacattt tcattttgtt ttgagctcca caaatatgta gctagtcctg 7860 ctaggaggca aaatagccag gattccagtc cagggagttt aaagacaata tgtttaacct 7920 tttaaccata cagcccctca ttctttcaca tgtttgttca tccatttact tttcagtaaa 7980 ttgtgctgtg agttcattat aaaccaggca ctagacttgg cagtgatgga acaatagagg 8040 caaaacagat gctgtccctt ctcttatgaa gctagcagcc tcaggaagga tgcaggccaa 8100 caaacaggta tttgcaattc aacatggtat gtgttatgat aggaaaggtc tggttgctat 8160 gggagcatac atataggagg gcacttaaca cagtatgggg ggattaggat ggtgtacaag 8220 ctgaggcata agggctgaat aagagttaca taatcaaaac tggagaatga gtatgatcta 8280 agctaaagga aatagaagta taaatgctta gaactgagga ggagtgtgac acaattgggg 8340 aattaaaaat agcttagtgt gaatggaata ttgaattagt cagctttcac tgttgtggtt 8400 cagtaacagc cccaccgtgt cagtagatta ttacaataaa ggcccacatc tcactcttgt 8460 tgctggtgat gtgctattgg gttgtgctgc ttctccccaa gtctccattt caggactaag 8520 ccaggaagag cagttcctaa atgaaaatgc cattcttgtg atagaagaaa aagaaagaag 8580 tagctgaacc acacacaata gctgaagctc tttggctcat attccattgg ttaatcaagc 8640 atgtggccat ggtcatcatg ggtagagcag ggaagtatcc tgctctccta gggggcacta 8700 caagtcacat agcaatgggc agatatgtta tagttctctt aaagggagag cagagactaa 8760 ctaggaacag taatatattc taccaggtaa gaatgagagg aggtgagtgg tatgagaagg 8820 tttttggaaa taattaggaa ctaggttatg tgttttatag aatatattaa agcctttagg 8880 tgcaattcat tactcctttc cattgtgtac tcattatttg gtcctacgcg tcctactcaa 8940 aatctgcttt tggaaaacaa taataataac aacagtgaca agcaaaacaa aaaccaagaa 9000 agataatgtc attacacact aaagtacaaa ttatccttta tacagtactt atatctttac 9060 agaaacaaag gaaataatca gttgtagagt ggcagtcact aatgtactag tgaagggtga 9120 attttgattc catctatgga aaaagatatt tcttggggtt ttggaaatca taccttgctg 9180 acttttaagt attgccctac tattaagacc aatccataaa tatttactga ttgcattcta 9240 cactttaaga actgtgattg ctgaattctc atcttcaaaa ttcagtcaag atgaatgaaa 9300 ggcagcctga tagagtgaaa aaagcatgaa tcctgtcctc cggcagacct gcatttgacc 9360 aaattaattt agttaatacc tgtatgaatt tgggcaagtt atctaacatc tttcaccttg 9420 gtcttctcat ttgtaaaatg ggattataat accttcgtca gaaccacaga tccaacaaga 9480 acagcaactt ttattggata ctgcttaaat tccaggcaca ggcacagggc taagaacttt 9540 tcattatgac tcttaaactt tgtcaaacaa tgaagtgaag actataattt tacagaggag 9600 gtaactggga attaaggtgt taagcaactt gcccaaggtc agacatttag caaatcatgg 9660 aacctgaaag taagcccagc cacacaatga ccgaagttga actctttatt actgggtaat 9720 aagaacagta atgaaaacaa gaataataac aaaccacaca gtattccaaa ctctttaaaa 9780 tattagatta tttaattctc agtgataccc tttcagaaca tgcaagtgat atagaatctc 9840 aggttcaaca ctctgtatat atataaccat atatgcatat atctattaat ctatgtatat 9900 ctctatatta attaagcatt ttttctgttc ttggtctgtt acaataagtg aggtaaagta 9960 ggctgttcaa tttattatac attaccatat tcaatggaaa atgctaacct ccaagttaga 10020 gaaaacttga tagaaaactt gttaacattg tttataagat gcttaaataa gctttgagtg 10080 aggatgtaag accctcacac tcaaatagaa ggtgaaaact ataccaaatg gactttttca 10140 tgtattttga attcagaggc ctctttttac tccctgtgga ttctgattat atttgagata 10200 taatcattag gttcaatgtc ccataaatat gtgaattatt aatataaatt attttcccaa 10260 tatttttctg gctttctttt tgtgtttttc tttccagggc ccaagttccc aaatatgttt 10320 ccttttgccc ttttattaga ttatcatcaa tagtaggtag tcattggctt tatttctttt 10380 cattcccagg ctcatccaac aaactgagga atgtcctata ttttgcctct cattgtctga 10440 gatgatcttt gtgtggtttc ttatttatgt atattttttt ccctccaaaa tcatatgaaa 10500 agaaattgca agttgaaaac attacttctg gaaatgctat tcatccttca gcacaaaatt 10560 tgactgtgat tttctaaata aaacaaggct ttttttaaaa ttatacttta agttttaggg 10620 tacatgtgca caatgtgcag gtttgttaca tatgtataca tgtgccatgt tggtgtgctg 10680 cacccattaa ctcgtcattt agcattaggt atatctccaa atgctatccc tccccccttc 10740 ccccacccca caacagtccc cagagtgtga tgttcccttt cctgtgtcca tgtgttctcg 10800 ttgttcaatt cccacct 10817 <210> 23 <211> 18379 <212> DNA <213> Homo sapiens <400> 23 aaacatacgt gtgcatgtgt ctttatggca gcatgattta taatcctttg gggatatact 60 cagtaatggg atggctgggt caaatggtat ttctagttct agatccctga ggaatcacca 120 cactgacttc cacaatggtt gaactagttt acagacacac aaacagtgta aaagtgtccc 180 tatttctcca catcctctcc ggcacctgtt gtttcctgac tttttaatga tcgccattct 240 aactggtgtg agatggtatc tcattgtggt tttgatttgc atttctttga tggccagtga 300 tgatgagtat tttttaatgt gttttttggc tgcataaatg tcttcttttg agaagtgtct 360 gttcatatcc tttgcccact ttttgatggg gttgtttgtt tttttcttgt aaatttgttt 420 gagttcattg tagattctgg atattagccc tttgtcagat gagtaggttg cgaaaagttt 480 ctcccatttt gcaggttgcc tgttcactct gatggtagtt tttttgctgt gcagaagctc 540 tttagtttaa ttagattcca tttgtcaatt ttgtcttttg ttgccattgc ttttggtgtt 600 ttagacatga agtccttgcc catgcctatg acctgaatgg tattgcctag gttttcttct 660 agggttttta tggttttagg tctaacatgt aagtctttaa tccatctcga attaattttt 720 gtaaaagttg taaggaaggg atccagtttc agctttctac atatggctag ccagttttcc 780 cagcaccatt tatgaaatag ggaatccttt ccccattgct tgtttttctc aggtttgtcg 840 aagatcagat agttgtagat atgcggcatt atttctgagg gctctgttct gttccattgg 900 tacataacga aatgaaggca gaaataaaga tgttctttga aaccaatgag aacaaagaca 960 caacatacca gaatctctgg gacacattca aagcagtgtg tagagggaaa tttatagcac 1020 taaatgccca caagagaaag caggaaggat ccaaaattga cactctaatg tcacaattaa 1080 aagaactaga aaagcaagag caaacacatt caaaagctag cagaaggcaa gaaataacta 1140 aaatcagagc agaactgaag gaaatagaga cacaaaaaac ccttcaaaaa attaatgaat 1200 ccaggagctg gttttttgaa aagatcaaca aagttgatag actgctagca agactaataa 1260 agaagaaaag agaagaatca aatagatgca ataaaaaata ataaaggggc tatcaccacc 1320 gatcccacag aaatacaaac taccatcaga gaatactaca aacacctcta tgcaaataaa 1380 ctagaaaatc tagaagaaat ggataaattc cttgacacat acaccctccc aagactaaac 1440 caggaagaag ttgaatctct gaatagacca ataacaggct ctgaaattgt ggcaataatc 1500 gatagcttac caaccaaaaa gagtccagga ccagatggac tcacagccga attctaccag 1560 aggtacaagg aggagctggt accattcctt ctgaaattat tccaatcaat agaaaaagag 1620 ggaatcctcc ctaactcatt ttatgaggcc agcatcatcc tgataccaaa gcctggcaga 1680 gacaaccaaa aaagagaatt ttagaccaat atccttgatg aacattcatg caaaaatcct 1740 caataaaata ctggcaaatc aaatccagca gcagatcaaa aagtttatcc accatgatca 1800 agtgggcttc atccctgggt tgcaaggctg gttcaatata cacaaatcaa taattgtaat 1860 ccagcatata aacagaacca aagacaaaaa ccacatgatt atctcaatag atgcagaaaa 1920 ggcctttgac aaaattcaac aacccttcat gctaaaaact ctcaataaat taggtattga 1980 tgggacgtat ctcaaaataa taagagctat ctgtgacaaa cccacagcca atatcatact 2040 gaatgggcaa aaactggaag cattcccttt gaaaactggc acaagacagg gatgccctct 2100 ctcaccactc ctattcaaca tagtgttgga agttctggcc agggcaatta ggcaggagaa 2160 ggaaataaag ggtattcaat taggaaaaga ggaagtcaaa ttctccctgt ttgcagatga 2220 caagattgta tatctacaaa accccgttgt ctcagcccaa aatctcctta agctgataag 2280 caacttcagc aaagtctcag gatacaaaat caatgtacaa aaatcacaag cattcttata 2340 caccaataac agacaaacag agagccaaat catgagtgaa ctcccattca caattgcttc 2400 aaagagaata aaatacctag gaatccaact tacaagggat gtgaaggacc tcttcaagga 2460 gaactacaaa ccactgctca atgaaataaa agagcataca aacaaatgga agaacattcc 2520 atgctcatgg gttagaagaa tcaatattgt gaaaatggcc atactgccca aggtaattta 2580 tagattcaat atcatcccca tcaagctacc aatgactttc ttcacagagt tggaaaaaac 2640 tactttaaag ttcatatgga accaaaaaag agcccgcatc tccaagtcaa tcctaagcca 2700 aaagaacaaa gccggaggca tcacactacc tgacttcaaa ctatactaca aggctacagt 2760 aaccaaaaca gcatggtact ggtaccaaaa cagagatata gatcaaacaa ggctttttgc 2820 gccttcagca ccttggttct tttaagcttc ctttataata tcttaagaaa atctgagtcc 2880 aggagcagtg gcttatgctt gtaatcccag cactttggga ggccaaagtg ggtggatcac 2940 ctgaggttgg gagttcaaga ccagcctgac caacatggag aaaccctgtc tctacgaaaa 3000 atgcaaaatt agctgggtgt ggtggcacat gccagtaatc ctagctactt gggaggctga 3060 ggcaagagaa tcgcttgaac ctgggaggtg gagtttgcag tgagtggata tcatgccatt 3120 gcattccagc ctgggcaaca agagcaaaac tccatctcag aaaaaaaaaa aaaaaagaaa 3180 gaaaatctga ggttgaataa ctaacaattt taatatttag ttaagaggcc aaatgaagta 3240 tttgtcctac cctcaagcag ccctgctgtc cttaagaaac aacattatat tttccaacgc 3300 acaacaataa aatgcactta aatggtattt ttttaatcca tgttaataaa aggattcacc 3360 acaactgatt aggcttaatg tgcatacaaa tcacaggaca gacaatattt cagttccaaa 3420 tcttaaaaga taaaattaat aatgatataa cttattttca ttcaaaacta aaatgccttt 3480 cagatggtcc aaaagtgttt catcaccata tggcagtata tctcaaagag tgatttgctc 3540 attgcctgtg caaggtccat ttgagggctg gaaaatccag gttctcaggc tctatcccat 3600 cttactgaat cagtgttggg gatttgggct ttgtaatttg cccctttaac aaactcctta 3660 gaggactctt gtgcatactg atatttcaga agcagtctta tggagaacaa aataaaagag 3720 gagataaaat atcttaagtt gtcaacagat agagatttaa caactatatg ctacttgcac 3780 tgtatcttcg ggtttaattt agatttagca actactatgc cacttgcatg ttaggatttt 3840 tagtttagtt tagtggcaag tgattaataa ggccaaacaa cttcatgatc ttctgttatt 3900 gacctaattt cacaatttaa cacttagaat tggaatatta gctactgtgc aaaattcagc 3960 cataaatatt taaggatatt tacaacttgg tttcatgctc cattaaaata tatttactat 4020 ttgttgttta gaattaaaaa ggaaatctga ggtctaaatg ttcaatgttt agattaggct 4080 agtctagaaa attcatcaaa ccaattccat ggggtagtgg gtatggtcat cttacaaaat 4140 tgaatgtata ctatttgtgt tatgagaggt tgaatctcaa agtgtggtct gtggaccaac 4200 agcatcgata ttacctagga gcttgttaga aatgcagaat ctcaggtccc acttttaatt 4260 tgctgagtta gaatctacat tttaacaaga tgcccaggtg atttacatgc acattaagcc 4320 aaagaagcag tgctctaaga aactgcttgt tcctagaaag tattgcttaa atataggctc 4380 agaactgttg tttacatagg acttgtggat ttctcttgtg gttaaaaaat ttaaaactac 4440 agttaagaga aacgagtggt ccttgcagca agctaacaag gagcccttga atattaagat 4500 ggttgatact taaggactgc agcaattgct gtctaaacca gaaaagtatc tgagcacaat 4560 tgacaatggt tccatagact cctggggata gtcacttgaa tgattaatta ttaattttta 4620 aaaagaactt ttttttctgc tgtgcactat acaaaagata atgtatatta aatataaaag 4680 aatcataaat gataaaagca tttgtatgct tagaaacttg gtaaagggga tagagtaaat 4740 gtataatgga atcactgcat ttatatcaat aaatgagagc taaaatattt ttataacttt 4800 tttgtcagta caataaagag gacttttgga gacagatggt aaatcaatat tgttttaata 4860 tataatatat aatgagaagg agcaatatga tctagaatat ttttgtatca ccaaaagcaa 4920 atatcaccat taacattcag atctgagaag aaatcaagtg tcaaagagtc cccaaaggaa 4980 agggagactt caaattattc aaagatgaac tggaaaaatc agttactttg tataactggg 5040 ggtatactaa atgtgttctg gtatggaaat tgtattcaat ttctaaacat ctcaggttgc 5100 atgaactggg caaggctata attagtgact gtgcggccat ataacctgga ttagactttg 5160 atggaaacat cacttcattg tgcatttctt gtgccagaaa ttcctatatg aagaatgaca 5220 tatgagtttt gtaagtcagg ctcataatca ctaagcccaa ataacttcat ggtcatctat 5280 tctcgaacca attttaagac ttaacaagta gggttggaat attggctcct gtggagaatt 5340 cagtgatata tatttaagga tatttataat atttataatt tgacttcata ggtaatttta 5400 tctttagtga atcccttttc ttaagggtag actactttaa cagaagctat taagatgaga 5460 aatattttaa aacagtgaaa agtccctagc ctggtcatta atagataaaa tgtaaattaa 5520 aaacaaaagt aaacacttag aatccattta cctaactatc gtcactcttt tgggggaagg 5580 atagaccttg gaagaaccta tataatgacc ttacaaagta actattcatc aaatagtggt 5640 ggactatagt cctacaaata ctggttcaat atcttcttag tcatataggc atttagcact 5700 gcactacaat tattttgaca ctatagatgc ttgttcacat tctgtgattt gatcacagca 5760 ggaaggacaa ctttaaatat agaagagaga agaaaaagat aatctccctc ctctctctgc 5820 tcatttcaca ccttcttgaa tgaacaaagt tagtcttttc agaatatatg tttaatgatg 5880 taataagtaa tgtgctacca aaatggcaaa atagatggac tagggagagc atcagtcatc 5940 cctgggagat gctttagacc cagaaaatga cttcctatga tctcacctgt gatgagatga 6000 gaccttttct tatctcatga aataatctct ctttttcctc tcttgtattt tttctttctg 6060 tccaatgagg aaaacaaaaa caaagaaaaa aatgaaaaaa agaaaagaaa gcaaaacaac 6120 acaaaactac caaaccaaca actggaaaac ccaaagcttg taaactgttt acaggaaacc 6180 aaatagtatt tcctgggaca tgagatgaat atgagatggc gttttttatt gtcactttgg 6240 gtacagaggc cgaaggtcat tatctaacag gcatacaaat ggaatcaatc tctccctcaa 6300 agagcctgtc agatgcacct gagccttccc gggtgtttgc agagtggttc atggtcaaag 6360 gcaagaatgg atattggcac ttcaggggaa actatatttt cctgtcaata gacagaagat 6420 tgcagtgtcc tagacaggta atcagttatc aaggaccaca atcagctcac gtttaaacat 6480 taaacaggtg gggcaggaga caagcaaaat ttatcatgtt tactagtttt gccaacaacc 6540 aaagaactgc tttattcttt ttaatcagtt ctaatctgtg cttctttata tctattttga 6600 aagacattca ataatttttt ccccttggca aacgcttggt ggattcatag agtcaaaagt 6660 ctatatttct ataagtatat attttttaaa atctcccatt tttctcttgg ctttggttag 6720 ctatatgtgt gtacaaatca gtccctatga cacccagttt ctatgccagt ttggtgaatg 6780 gtgtggggaa agaaattgaa aaaggctaaa gcaaaccttc tcctaagatt aaacagtatg 6840 tggtttgtta agtttttttt tttttcctat tccaccatta aaagtaaaga agaatggctt 6900 ttcttttttt ttcctgatta gaaggcttca ctggatttgt ggcaaataaa ttgacaagtg 6960 agggcactga tgacaagaga gtgataattg atggtggcag gtgggggcct ggtgtactgg 7020 catgtcctgt ggagggtgag ccaaggacat ctatcaatca aattggtgac agcagccagg 7080 gagacttaat tggagattca ttgaaccttt aatgttgtga cagagaaaaa taaggatgct 7140 taaaaggctc ctgggctatt tcttttcctt cattccaaca attctcatag aaagaatgga 7200 aagtggacat tgctccaggg ttgaacattc attgtttcca tcaaagttaa tcacattttt 7260 ttttttagga agcaaagtag tgaaagtatt taccattagt ccaatgtgga atgaaatcta 7320 tacctggagc tttagggatt cgactgttct gtggtgttag cataatcagg gatgtttagc 7380 aagtgttcag acaccatgtg cttaacactg agtgtcaact agggtgcaaa tattgtctgc 7440 tggagtgtgg attccaggca tcataaggaa aaaagtcctt ttcctaattt aataatcttc 7500 tcttcattct tctaaaaagt tctctataca atccagatgt aaatattttt cttttttttg 7560 tgtgttgttg ttgccagagg ttcaacataa ttttatttct tatttggaaa atgaaagaat 7620 tcagtagagc tattttccct ttaggcacag tacaggaggt ttttcttaaa attagtagtg 7680 caggaaaaat cccaacagtt caagacactg tatgtggata taatgtgtga aaagataagt 7740 aagatggtct ctgtcatcca agattatata tttttatatt tatgagttta tacatttatt 7800 tattcattct aaatcataag tttgggcact tactatgcat agtgatttgt taggccaagt 7860 ctaagatcaa taggacctcg ttatttcttg gaaggaattt actgtttagt gagggaagac 7920 agatatatgt actgagacat taaatattgc aatgttctag gtaagaattg agagttgtga 7980 tatcacagtc taggatggta gaggctgcag atatcaggcc acttaagtga caatttttgt 8040 cttttgaaaa ttgctagaat actgcttcaa aaagattgga aagaaagtaa agatcctaga 8100 cttgctatgg cagagatttt atacttaatg gcatccccat ttagccaaat ttttaagtca 8160 tagacagcag agagggatta cctacctctt ccaccacttt ctcacagttt gaaattcagc 8220 attttgccat aacttttttc tacaaggcac tgaatacaaa catttccctt taattactaa 8280 atggaggaat agtaatttaa attagtaatt tttaaatttt actagtagta aataaatttt 8340 agtaactata acttttagta atagtaatta aatagtaatt ttaacttttt catcataatt 8400 ttaaaagttt ccagaatgtc agcatgttgt tccacccagt cacaatttgc ttttccctgt 8460 gccaaggccc cagttcagca tttattctcc gtattatgca cttcaacaag ggttgactgc 8520 ttgaaagtcc tcctgttggc tgaactgtaa ataggctaca gattactcaa ttgtcttcct 8580 ctagaatctt gtgtctcttt ccctgcatat ttacagatgc cttgaaaaaa ctcacagagg 8640 caaaaatcac ggtaatcagg aaactgtaac ctggcaaaaa atctgtagag cctctcctca 8700 ttattgagaa cagctgccac tagccaagtg catactatac ttttcaggaa aaaaaaaagt 8760 tcatttaaaa gtaatttgag gcaggtggta tcatagaaga aaataatttt atttatttat 8820 ttatttaaga cagagtctct cactttcacc caagctgaag tgaagtggca tgatttcagc 8880 tcactgcgac ctccgcttcc ccgggttcaa gcaattctcc tgcctcagcc tccgaagtag 8940 ttgggattac aggtgcctgc caccacgcct ggctaatttt tgtgttttta gtagagactg 9000 ggttttgcca tgttggccag gctggtatca aactcctgac ctcaggtgat ccacctgcct 9060 tggcctccca aagtgctagg attataggag tgagccacca cacccggcca agaaaagcat 9120 tttaattaga atacttggaa gatacatttt gaaaaggaag attctagatt aaaattttgt 9180 gctatatttc attgtgcttt tttcattgaa aatgttgata taggaagaat tctgtcatct 9240 gtatcccgtt ttttcaggct catcaagtct tataattaac tttcctaggt cctagaaata 9300 tattattcct aggttagaat attttctgta gaatacaaat tatttataaa ccatcagcat 9360 gggcaatgag ccagctcaag attttgttag aaacaaaaac atgaaagtca aagttagaat 9420 gattctttta aagtattttg gtcaaatcat caatgtggta atcaaatctc ctttagaaca 9480 ttttctccat gtggtcttcc attccaagtt tgtacatgtg cagcaaggca gactctacct 9540 gccatctatc tctgctgtat ttgtattcta tcttttaatg actgtctgtt aaatactttt 9600 tgttaatgtt ggtaagaaat caatctcttt gtagcatgta gtctctggac tggattcagc 9660 atttgtcttt ggatatttag attaaccaga aaaactccac ttgaaaattc cccaactgtt 9720 tgaagatagt tattgtatcc cttccaaaac tctaattttt ttaaaaaaat taaacattct 9780 tcttcccctt agccatctta cccatgttat ggttttaagt cccttcatta tcaaaagtgc 9840 tttgctctgt gctgatgtaa ttatgatcca agtgtctcta ggcacttctt agaacatctt 9900 gtcaagactt gaacacgaca ccaggaaagg tttgaccagg tttagagcag ggaaactttt 9960 tcttccctta caagttgcat ctcttaaatt ttttttttct tgctgtattc aggcctttga 10020 tggttaattt tatgtgtcaa cttcactggg tcacagtgcc cagatatgtg gttaaacatt 10080 gtggacattc aatgaagatg tttttagatg agattaacat ttagacttaa cattagattt 10140 tgagtaaaat agattaccct ctattagtgg atgggcttca tctaatcagt tgaaggcctc 10200 aatagaacag acggatttcc cgagtaagaa gtaattcagc aggcagatgt tcttcagagt 10260 tgaactgcaa catcaacttt ttcctgtctc caccctgccg gactaccctg cagattttgg 10320 atttaccaag cctctataat tgtgtgagcc aattccttaa aagaaacatg gatgtgtata 10380 atacacacat acacacacac aataggatat gtgtgtgtgt attatgtatt ttatatatat 10440 atataataca taatatgtat gtaatacaca tacacataca gatatcctgt ttgttctgtt 10500 tctctggaga atcttgatac aaattcaaaa tgacggcctg tatattttgt catcttgatt 10560 gtgtcatcta atatatttct tttcatcatc atctttgtgt catctacaaa tttgacaaca 10620 acaagagctg ggtgtattct ttttagtcta agaacaatgg attttcttca ttttaatgat 10680 tataaaatta cctttgatgg aaatggttct tcatagagaa gcttctacca actattgctg 10740 attatgctta gtgaaagatt gagaacatta acactgcatc tcagctcccc ctggtggaca 10800 caaccctcac agacattctt caatagaatt gccgagtaga gtaatagatg ttattgatag 10860 agtgtaaagg cacatggctt accgtaaccc tccttttaaa aaggtacttg gataaccata 10920 aattatgaca cccctcttga gattttaact atttgtgaga ccctgaggct ctctcctcac 10980 cataatgact taaggttgtc acagtgatga gtaagttgtt ttatgaatat tcaaaatatt 11040 tagaaaacaa atcatacaga cctaatataa aaattatgat aacagattgt ctaacctaga 11100 actataaaac accatttgct aacacaatct ttattaaata agcagtaata agacatctta 11160 cattttattt ttctaattct attagaatta tcttaatgta atacttgcta tctaccatta 11220 agttttttta attataaaag agtatagctt aaactaaaga aaaaaatctt atatatatta 11280 agaattacaa ataaaagcta tgtattgagg gcctgttgta ttatatatac tccataaggc 11340 agtttacata ggttaatatg catatattcg caacaactct ataagctaag ttgttttacc 11400 ttcattctgt atttcaagtt tggcaaacta tggcttgtag gccaatatag cccttgtatg 11460 gaacgtattt tacacccagt gagtttaaaa tggttttcaa atttttaaat ggttgggaaa 11520 aatcaaaaga agaataacat ttaatgacat gtgaaatctt ataaaattga aatttctgta 11580 aataaagtct tattggcaca tagctatatt cattcatttc catattatcc atggctgctt 11640 caatgctata acgacagaat tgagtagtta cagcagagac actgtgctat ggaaagtcca 11700 aaatatttat tgtactatct ggccccttac agaaatcatt tactgattct gctgtatctg 11760 atgaaagtaa ggcttcacat ttttaagtga tttcttcaag agacctgagg ataatcaaag 11820 taataatttc tttgttatta gtttcttttc tatcccaagt aattgtgtag tgaattctgt 11880 actaaatatt aatatatgca tttagagaaa caaatttgaa acaggataaa aagtgttttt 11940 aaacaaattt aagtcaatat ttacaaggtt tttttgtgtg tgtacacaag aagtatatat 12000 tggtagaaag acaagtgact ggagtgtaca aataaaatgg agatggaatg gacagttata 12060 aactcttaaa attcataacc aggcactaag atttcatggt tgttctatac agtaggtaag 12120 ctttttgtcc catcctggat ttatgttttt ccatttctaa gcatcagtga tatggttcca 12180 taatgtggta ttgacaatga cgtttaagag gaaacataga gatgcataga catgaatggc 12240 tcctgtgttt atgaagtggt atctggaatt aaataggaag atgcatgtga tatgcttggc 12300 agaaacccta gtaaaatgtc aataaacaat aatcatcatg atagttgtta gaaagttatg 12360 gttggcatat ctataattta ttggagatat ccctggaatc tggacactgg ggcagtcttt 12420 cagatcttcg atatgtctta tagcatggtt tctagtgcta gatgatgagg attcaagatg 12480 atttaaagac aggagtaatt attttactgg aaaatactgg ttaaatagat tttttccctt 12540 tagaaaggct actgaacaac tagaaggtgg acataaatat gttgtttcct tttacatttg 12600 ctctctggag ccaggaaggg ttaagaaaga gatacttctt tcctcttagt cgggattcat 12660 acagaaatca agagtgggaa ggggccctca ttacatcaga cacagttact ttaaggatga 12720 ggaatctgag acccagataa ataaaataat ctgcctaaag ctgacccaga gttagtacgg 12780 ggctctggac gatttcatta tgtcatgata ccattctctt ccaaattcta agattggaaa 12840 atttacctca tatgaagagt gaatttaatt tatctttatt ctagtttccc ttcaaaggca 12900 tgtcttaata tacatggata agtcatttca aaacctctaa gcctaaggta atttgcactg 12960 caaattattt cacaccataa tatctatctc agagcttttc ctgagatgta aagtccttga 13020 tgataaaacc gactccgtag taatagtaga ggacttattt gtattgagaa tgcagacttg 13080 agtgcaaagg ggccagacaa gtaaagactg tatgtaaatt agtaaaggag taggagatga 13140 aagacaatag ggagtagagg agaatgtgct caactagaaa agaaagagct aaaatatgga 13200 cagctgttac tcagccccat ctgatggtta ccatgcatgc atgattttga atttgctaaa 13260 tcctctcaat tcaaagaagc tgaaaatcta gacttttaaa tgtggagacg ttctgatttc 13320 cttattactg catgggtcaa acaaaacaca tctgcatctc tactaaaaat aagaataaaa 13380 aaagaaatta gctgggcttg gtgcggggcg cctgtaatcc cagctacttg ggaggctgag 13440 gcaggagaat cccttgaatc ctggaggcaa ggtctcagtg agccgagatc gcactactgc 13500 actccagcct gggcgacaga gacgaaaaaa aaaaaatctg tggactggtt tagaccttta 13560 ggaagcatca tcagcaatga aaaatcatga tgttttcatt aaaaataaga gttttacatg 13620 caatttgggt tgtagggttt acagtttaat attttatgat tctttttcct ctttttttaa 13680 tcccaggagc aagagcatgc catgaatcta gcctgtagat tcagcgtggc tttctggctc 13740 aaacttagac tgcatcaaac agctttgctt ttgttttctg cttgaaaaaa ctgacacttg 13800 ttatggttac actcactgtg tgagccatcc cctgttgact tctggacaat cactataaat 13860 ctctattatt tcgctgttat tgtcttgtta tactagcact gttgaggcat cttctcaagg 13920 gaagtgagcc caggtgtgca catacagaac aagaaatact ctcccttaaa cacataaata 13980 gctattttat ttggcacaac acacacaaat gttagtgtag ccaaaggaat cttgaacagt 14040 tatttgcatt gcaaatactt caaaaaactg gagcaaaggt atcagagctc aatctgctag 14100 ccatttgagt ttcattagtt cagagaacaa tccatctttt atttttttcc agtaataaga 14160 attgaaatga aattcagtgc cttacaatca ggctccaagg cataagaatt tctcataaaa 14220 aagaatatat tcctgtttcc ccatgaaatt cagttatata aacctctttt tatgggtact 14280 ctttctttat ggccctgttc agagaaaatg tgcagggtta agctctcttg tgctacacat 14340 tcattgtttt gatatacaat ccgatggaag actgcaacag tgctttctga gatatctggg 14400 catgaaggtt tgaagattcc caaggcaaaa agttatgtca atttccttag tcgcacatgt 14460 gattaagggg tacctttggt tctggtactt gccaattcat gacgtggcaa aaaattacat 14520 aaagaacaat tggcagatag gaggttgtgt tttagaggcc tgagtagaat tggggaaggt 14580 ttaataaaag ctggaagctc agtttcatat aattcacaaa aagctaaatc tatatttata 14640 agagttaagt aagaaagaaa gagatttggg gggcaattaa ttttctatgt aagtatgtat 14700 ttatttggtt gatgggatcc ttggtgaatt tctaattttt attattttat aaatttagta 14760 aaacatgaaa aaggaagcaa aacttaccta tatgcataaa gctttgggga aaaagctata 14820 acagactgaa acaatcactc tccactttac agtactatct tcagactcat atgaatatga 14880 ataaaatatc tgaacataaa aatattttta ttttatgaaa aatgagatca tactgtttat 14940 tcctgtttta aatttaaaaa tacatattta ataacattta aaaaataaag taagaaattg 15000 tgacccaggc ggtttcttga catatactga tgtgcatcct ccccaaaccc caagttaaaa 15060 gaaatgataa aagtcagtaa tcctctaatt acgaatcctc tgattttgta taagcttcca 15120 ggacaaagaa actttgtgcc cttttccata aggaacaaag agggccctgt gggaacattc 15180 tgcattcacg taggtttgga gaggagaacg gaaagctaca gaagcagaca cattagcaag 15240 catattggta ggatgattgt agttgtgaga attctgaaac aaatgtaaaa agggtgatgt 15300 tatgaagact gaagggaggc tattgttaga ttgcttggaa aggaaaggcc cggtgaaaaa 15360 aggtacactc atgctgacac ctgattgaca agaagaagcc agacacgagg attgcagatc 15420 cttctatgca aagggtaaag gaaatgcaaa tcctgatatg aagtaaatat cctagatatg 15480 tattagtaaa tagcatccaa aggtatatta ttagaatcat tgtatgcaga gttattccag 15540 caatgcaaag atttcattcg gaaaagtttt aatgtaatta attacaatca taattacata 15600 aaaacctcca gcaggaaaac aatttgatga taaacaaaag agtgactact taaatgacag 15660 gtgactttta ataactgcag tggaagtcag gtgatagtag aatgatatag ccaaaatatg 15720 aaagaaaata tctattaacc tataattcta tactgagcaa aattttattt ttcagaaaca 15780 gaaagaaatg cttttttggg gtaaacaaga actgagattt tactgacaat agaatttaac 15840 taaaggaatg tctaaaactt ctcctttaag agagaaaagg atcatagtgg aaaagtcaga 15900 agtagtacca tatgaagaac ttatggtaag caaaacaatg gcaagcctgt gggaaaaatc 15960 taaaccatca ctgactgtaa aacagtaact atcttgtcta attgggaaag gaaaaaaaaa 16020 acttaagata gaaataaaat gtgaaaggat gcctgtaatc ccagcacttt gggaggccga 16080 ggtgggcgga tcgcctgagg tcaggagttc gagaccagcc tgaccaacat ggagaaaccc 16140 cgcctctact gaaaataaaa aattagacgg cttggtggca cacgcctgta atcccagcta 16200 ctcgagagga tgaggcagga gaatcacttg aacccatgag acggaggttg tagtgagccc 16260 aggtcgcacc actacactcc aacctgggtg acagagtgag attctgtctc aaaaaagaaa 16320 aaaaaaagtg aaaagaaaat aaaatctcga gaccccaaac tcactatgcc aaagggaaaa 16380 cttaagcttg gaagctgaga cacacacaca cacgtgcaca cacaccccaa aaaacccaac 16440 tcaacccaaa ccaaaccaaa acacaagaaa acaaaccaaa aactgacttc ctcttgtttc 16500 caaacagctg taatttcaca gctcacttta tcttatgtaa aatgtagatt tactgagtgc 16560 tagaggaatg cataattgac cctccctttt tgcatgtaaa atgtggactc agtgagcact 16620 aatcaaagcc tcacaagagt gtaaccactt gcctcgttgc ctaacctcct cttttatttt 16680 tctttcctcc tctccctcct gcttgcttgg tccccttcaa atattgatgt cctcaaaact 16740 gtctttggaa agaagcatag gccatggatt ctattataac ttgtgattct gtttcttaga 16800 cacatcctta actttggcaa aataaacctc tattccattg agatgtgtct cagacacttt 16860 gtggtttata aaaatcttcc ccaataatat tatataagtg aggaaggagt gtgattattg 16920 gaattaacca ttgtaaggtc attgtatttt tcagagggaa aataaagata ttcagcttag 16980 aactgatgag gttaaataag catgctaaaa tttctggaaa aacaatgaaa tgaaaaaagt 17040 tagacgaggt acttaaaaat gagtagaggg aaaacatcaa atggggattg gggagaccac 17100 gtcaattcaa aagaagaaaa aaagagaaaa aataagcaca ctaggaaaga gggggaggac 17160 aaataagtaa tacaaagatg gtagaaatga gtccaaattt ctaatcaaga tgaatagagt 17220 aaaccattta cttaaagaca gaggatcaaa ttgaattaaa aagcaaaata caattatatt 17280 tgtcttatag aacttaactg taaaaaataa tactttgaaa atatatcaga gcattttttt 17340 ggaaccctga gatgcctcct gaagccacga ggagttaatg gcaacccttt gtcttacaag 17400 gccttacgta atttaattct tcaactttga atttcttgct cactctgctc aaccacatta 17460 acctctttgc tgtttctgga gctcatcaga cacatgccag cctaaacgtt tgttctagtt 17520 tttccctctg cttggaatat cctaaaccca ggtatctact tagctaactc tctcatcttt 17580 ggttccctac tcaaatttta cattctcagt gaggcccacc tagaccacct tacttattcc 17640 tgcaacttgc tcacttctct tcactttcta ctttctttct ttgctctggt aattattggc 17700 acttatcaac ttctaacctg ccatatcatt taacttttaa aactgattgt ttattgtttg 17760 tttttctccc ttagaatata aactcaagga ggaaaggaat ctttttctat cttattcaca 17820 gattctggaa tagtgcctgg cacatagtag gcacttgata aatattcact gaaggaataa 17880 atgagtgcta tttctacccc taatttacag cacaacatct ggcaacattt tattaagtaa 17940 aataaccaat aagtaaaaag caaatataaa atttgatttc tgtattttct cttcgtattc 18000 tggaaaatgc tttggagatg agggtagtag gaagaaatgg gaaaaaggca gagggagatg 18060 agcctcctcc ctttccactg gatgagatgg ttgaactgca ggtcccttga tgtttccaca 18120 ctagcagaga attctctcat ttctcttctc agggatgatc cttgaagcag gatctacaat 18180 agacagcatc aaaatcaaca ggcatatgat aactgacagt ttggaaaact atgacctaat 18240 tgatgataca agacccatta gtttgtgggg cctaagagga aatttcaaca ggaaagatta 18300 gtcttgcagc ctgacttgtg gatgcagcag ttgcctcatg ctatggattg cattgtatca 18360 acccctaccc ctcaaattg 18379 <210> 24 <211> 3454 <212> DNA <213> Homo sapiens <400> 24 agtatgtgca tttgtacctt gctttgtttt cctcaacttt gtgcttgttt ctgtaattcc 60 ctcattcatt cctacctctg catgcttgaa agttctttgt ggataaggac ttggtccgaa 120 ttatatttcc tttcccatcc catgcacgtg gtcctctctc aggaaatagt gcaaatgagc 180 aactattgca ccaagttagc cattctctaa acataggtac tacctatgca ctttacaatt 240 cttgcttcta atttatttct gggttgcatg gaccttacaa aaaggagtag cctttttgaa 300 aagattggtt tgaaaaaaaa caatttcaag catcgtttga aaaggctgcg ggaccaaaaa 360 gccagcacag ctcaagtcat tttaaacatg caatgattct cactctgaat actcagagtg 420 gagactcaaa gtgtggctct ttgcaagtta atgtcactct ggccattcct tacactttga 480 tcattcaaac agaagtcaca tgtggtttcg tctcagctct aagaaggcca aacatgaatt 540 tctcaagcct gtccaaacaa tctctcagaa aaaaagatag aggttggatc atttgttcat 600 acagtttgat tagctaacac acattttata gtacttgaag ggttgttgaa aaggagttcc 660 tgtcttatca ctagaaggtg aattcttgaa cctgtaaaat aaactagtta gtttgcatgt 720 ctttatattc cttccatgca tttagatata cctatttcca gacaggtttt cagaatgcat 780 ttgggaagcc tgtgattaaa ggatattttc tggtatggta tgaaggctga gtctcttgac 840 aataactttc agaaaaagaa taaaatctat tttacatcag ctgaatgtct ctaattgggt 900 cttgaagacc aaacagttcc cttcaatgca gctggggctt tgggtagccc caaaccaatt 960 aactcaaatt atataatttt cttcccatcc ctacccccaa agcttgactt gcttatttag 1020 taaagaggag gattagcgca agcactaagg agctgttctc tggctgcctg gcacaatatg 1080 tgaacttact tctgggccag ccagaagcat cctggctggg aagaaaggaa aaggggaagc 1140 tgaagtgaag ccgtctcctt ggtgtgactc tcctctttct tgggatacaa tggaactcag 1200 cagaaatata ttactggatt accaggcagc agaaagcatg ctggccttta aatgggaaca 1260 agcaatcttt agccctccta aacctctaaa aatgtgcagg agctaattaa ggcaacaaca 1320 tcatgaggtg atcagagaag agcagagaaa tgtgaacggt tagggggaat ctgaacaggt 1380 gtgtatgtgc ggtgtgtcta aaggagcaaa aagctttact atgaatagat ttcatctttc 1440 ttctgtttcc aaatgatttg ttaagcctgg ggtgagcatt gaacaaataa caaaattatg 1500 taacaattcc aaatgtatat tttccaaatt aaaaaaaagc aataatttta aaaggcagaa 1560 tgacaccctg cattgcaact gtatcagaaa tatgcttagt aacctttatt acaaggcagc 1620 ttaatttttt ttctatttta tatagagtac tgtcttttgt gatccttgta acaagatact 1680 aaatacctga tttgataatt gtgacatata ggtgaattta aaatagttta gttctaataa 1740 gaaagaataa ttaatgatac cttcaggtgg gcaggttttt tcaggggagc attttttcat 1800 atttattgga cagtgaaatc tcagcttcta agtgctgacc ttttatgtgc caacaagaga 1860 aagcaaatag tagacatgcc tcaatgtctc ccttcttttc taagcttata aaatatggta 1920 cttaacttgc cgtggtattt tctcacacat tcctttctga ggggaccctg ccctggatac 1980 cagtagaatg gttttataca acaggcttcc ctgatgttct aggtcctggg agttatcttc 2040 taagcttgag ttttttgctc atatgtctgt caaaaaggaa aatccagtga aattaaagtt 2100 cgtcaggaag ctacaagtct gttttcttac agctcccatg ggcaaagtag cattatatct 2160 tctgttgatg tcaccatttc tctgggagat tctagaaatt tgttcattgg tttccttcag 2220 aatctactga ctaccaatgt aaactcacag ctggagagcc acatcccttg tccttttgga 2280 ccatggtacc tatgaccaag gcttaggcct tttctgttga gtctctgtct ttggggaggg 2340 ggataagttc ttaaattcag ggccagagtt ccaggaaagg tattcaagta agacacagag 2400 caaggctacc aattaaaata aagacaatag actttcaagt tcaaattctg agaagaatat 2460 taaaaattat ttagtctaca ctgtgatttt aaagagagaa ccatggtagc ccaggaggga 2520 ggttgacttg ttcaaggtca catggtggct tagtggtact gcctgaccag aacttggttc 2580 tcctgatgca attgaagagc aatctctggc tgtcaatgct gatcacatct caatcataga 2640 aacatctcct ttatttttct gactttatag attgctaatg gcaggagaac actatgactt 2700 acaagttgag ctttcacctt gctggccctg gctgggcaga cttggcatct gtggttgagg 2760 ctttaaggtg gaaaaacagg gcattaccag tgcttctttt cattgaatgt acatttgaga 2820 gatgcattaa ttaacgtaaa attgctacct ctagctctga gccttagctg gcgctccact 2880 ttgtactgtt caccaaaatc aaagcaccgc tatggtttat tttttagata tcttgaaaag 2940 gataatgttt gaccattcct ctccttggct ttacctccat gtgctgtgtg taatgatcca 3000 gagagaatca attggacact gcattttaaa gataaggatt gggattttac ttctgggtaa 3060 cctggtgacc ccaatcaatc tctgtcttac gaactctctg aagatttgat gctccagtcc 3120 gcaattaagt cccagcttcc aagaatggca acagatgttg caatccaaac acctttatta 3180 actatttatc ttcaaatata tatcaacgat ctcttggcca acagaaagag tggcctgccc 3240 cttaaatgga aaatcacact ctttcatctt caagctattt tactttatag tccttttgag 3300 aagataaaaa gagatctatt aagaaagtag ctgacaatat ataattgctt tcaaaatttg 3360 ccttttctaa aagtagtttt tatctataca ttgaaaatat tgctattaag ttgtatacct 3420 caactataca aaacatcaaa tggtatttag ggta 3454 <210> 25 <211> 27712 <212> DNA <213> Homo sapiens <400> 25 accaaaggac atgcgaaaac ttttgggtgt gatggatata gtcataatct ttattgtggt 60 gactgtttca cacatgtgta catatatcac aactcatcaa actgtatact ttaattgcgt 120 acagtttatt atatgtcagt tatacctcaa taaggctgga aacaaaaagt gctctgggca 180 aagagtctgg tgacttaagt tctgctttta ttctgggccc aagttaccat gtcaccttgg 240 ccaagtgacc caaccctaag aggctcgggt ttttcacctg tgccctggga ggtttgggtt 300 agatcgttga gtggtaagag caaatgctct caggggccag gaaggaaata caaatgaatg 360 acataagcca ggttcaccgc ggagaggggt agagacaggt agagactgtg gctacctgga 420 gagtgttgcc tctgcccagg ggggcagctg ccaatcagct ttggccattt gctgcttaat 480 ggaatgtggg cggtgatgct cacgcttcag agtctttaag agaaaccaca gctccggatt 540 cctcaaatga aatcttcccg ttatcaaatg tagataatta acttcaaaaa gttaaaacac 600 tgtgcaggcc aaggccacac atgtgcagac gagacccagc ctgagcccca cttgtttgtg 660 gcctctgcac tctgtgatgc gtggggatgc tcttacccga ccaagaatct cttctctact 720 tttagccaaa gttgcttccc taattctttt tacctatact tcactaagaa aaaatgtcca 780 tcaatgccca tttgcaacct gcctgctttc catctaccat tcgatctata gagtgtctta 840 actcttggta gacttgaatt cttatttctt cagtttgtgg aggagacatt ctgggcaatc 900 ttgccgagtt aaaagaggct agtacctacc aaaaagagtc gaaagcaagg actccatcag 960 atatttggat accagtgttc aaagtggcat tattcacaac caccaaaagg tagaaacaac 1020 cccaatgact attgacagat aaatggataa acaaatgtgg tacagtacaa tggaatagga 1080 ttcagacata aaaaggaatt aaattccgcc acatgttcta ccagggagga accttgacaa 1140 cattatgtta agtgacataa gcgagacaca aaagggaaac tattgtgtgc ttccactagg 1200 tatccacgag agacctagaa tcgtccaagt cacagagaca gaaagtcaaa ttcatggaga 1260 ccaaagggag gaggcatgag tttcctgggc gcagagtttc agtctgggaa gatgaaagaa 1320 ttctggagac ggatggtggt gatggttgta caacaatgtg aatgtacttc atgccactga 1380 actctatact tcaaatggct aaatcggtat atatttatat atatttatat acatatatat 1440 aatacatata tattatatat gtatcccaga acttaaaatt atatatatat tatatataca 1500 ttatatatta tacattatat attatatatt atataatata tattatacat tatatattat 1560 ataatatatt atacattata tataatatat ataatgtata atatattata taatatatat 1620 aatatattat ataatatata ttatatatta tattatatat tatatatatt atataatata 1680 tataatatat tatatattat acaatatatt atatattata taatatacac tatattgtat 1740 aatataaaat ataatatatt atataatatg tattatatat aatatataat acatattata 1800 tataataata tatataatat acaatatata ttatatatta tataatataa aatatatatt 1860 gtatattata taatataatt atatattata tatataattt taagttctgg gatacatgtg 1920 cagaacgtgc agttttgtca cacaggtata cgtgtgccat gatggtttgc cacacctatc 1980 aacccatcat ctaggcttta agccctcctg cattacgtat ttgttctaat gctctccctc 2040 cccttgcccc catcccccga caggccccag tgtgtattgt tcccctccct gtgtccatgt 2100 gttctcattg ttcaactcta aagtggtaca ttttatccat tatttttttt tgtataaaaa 2160 ggcaggacac gtctggaatt ttcagatccg atgatgtaat ataagaggct ttcttttcag 2220 cacactgtgc taaggagcca cggctggagc tcccattggc acggtgtctc tgcaactccc 2280 tcctcaggct cctcacacac ccggggaccc cctgtgagtc cctaagctgc tcttaggctt 2340 cacccatttt gcaaagtggg tcttggcccc agctacactt tgagagcttt tgaatagtac 2400 agatacctgg gccccaccct tggagaatct gaatcaattg gtgtggtggt ggaatccggt 2460 ctccacattg actcagagcc tcccgggtta ttctaatgtg caggcagagt tgagaaccac 2520 tgaattctgt tctgaaaaca tcagcaagac ctttcatgga tattataggt aagtaaatca 2580 aaaccgcagc agacggtgct gaacagatcc atggggtgag ctgttctggg gaggcgggtt 2640 tatcccggga agggttctgc aggagtgggt gggcctggaa gtgggaatat ctgtaccccc 2700 attaagaggt aagaaatgag caagccatag ttaaggagcg tgtttgttgg gagggaggag 2760 aaacagggtt aggattaagt aataaaacgt gagacaagaa ggcctgcaat tcccaggtga 2820 agcgcttgga gtctttctat tcctgggagc aaatctaaca catgggaaat atttgcttct 2880 gcagagaact tcttagattt cacttctaag tgaaatcagg taagtcagtg gtaagaaaaa 2940 tcataataca agattctcta aataagaatc tacttaacct gctgcaattc tctgtcaaaa 3000 tatcctatgc cccagtctca aggtaggatt tcattcagaa ccgtatctat ccccacaaaa 3060 ccacttgaat gaagttaggt ttatttaatt tggtgacttg accgagtcag cttgttgagg 3120 gattggggat gaaaatctaa agggaaaata ctggactcgt gtaaatttag actccttggc 3180 tctgtcattc taaatgtttt atgcaacaaa gttggagaat caatccattg ctccaactgg 3240 ttccttttcc taaacagcat cttctccaaa tcttgtcata gaagtggtgg tagtgaaatg 3300 actgtcatgt gcaagcaaat catgaaaacc tatcagagca taatttttaa aaatcaagaa 3360 tgagaaaggt gctctggagg gaacaaaagt ctttatttca tggaaacaat tatgtgatgc 3420 tcagaagttg atcaaggctc tgaaagtcac agtgcatggg attatccatc ttacttacct 3480 gtaagtcacg tctctgtcaa tcttacctgc tcacgggagt tggaaactga aaatcataac 3540 aatatcaata acactagcca acttatattg agggcttgct atgttgcagg cgctcttgtg 3600 cactttgcat gtatcaagat ccttaatcct cacaacaaca gcatgtgaca ggtactattt 3660 ttgccatctc tagtctaagg atgaggaacc tgagatgtag agaataattt cgataattta 3720 cccaaggtca catggccagt aagtggcaga ctggattcaa atccagctgt caagttattt 3780 taggtcagag cctgggctcg tcatgtacca ctattacctt ggaagaagga agaaaaggta 3840 gaaacaaaca cttagtaagt gtttattaag tgccagctat tttatacatt atggtgtcgt 3900 tgaaccccta ccacatatcc ttagcctcat gttacagcca ctaggaaatg tggacagaga 3960 gtttaatgac tagctagcaa aaggcagcct ttatttgtct gaccatacac ctgtgcattc 4020 ttcactaaat aatgaaattt cagagtagca ttcatgcaag aaagcatgct tagggaagaa 4080 agtctcttgc ttagagtttc atcctttact tagtgcagtt ttaaccagtt tgcctatctg 4140 ctttcctttt caaagccagg aagtgtatgt ggggtgggag caagagggaa ggtgggtgaa 4200 ttgctggaga aataagttta atagagaaaa taaatgtcca agagatgagg attattaaac 4260 aagcagtatc ctagctatcc atctttgact tctttgagtg gaagttttgg ttaaaagcta 4320 tatgctttct ttaaaggaat caaagaaaga ggttggatga gtttgttagc agcaatgaat 4380 ctatacaggt ctgtagcaac ctcaattctt gattcctcag aagaaagaat ttgaccgggg 4440 gacataaggc aaagtgagac caaggcaagt tttatagcag gagtggaagt ttactaaaaa 4500 gttttagagc agggatagaa ggaagtaaag tacagttgga agagggccaa gtgggtgact 4560 tgagagattc aaatgtgctg tttgactttt gacttagggt tgtatagttt ggcctgcttc 4620 cagtggggtg tgtctgttct cccctgattt ttctcttggg gcggactgtc tgcatgtgca 4680 gtgggcctgc cagcacttgg gaggggccgc gtgtgcggtg tttactgagg tcgagtgcat 4740 gctccttgga ggcatttttc ccttaccagt ctagggttcc tagatgaagg tcacatacca 4800 gttaaatgaa gtccatcgtt ttacctctca atgcacatgc ttgagcccac tcgcccaact 4860 cctgagatct tatcgggaag ctgctgccta ccaggttcgg gtgttttctt ttcttttctt 4920 ttctttgttt tttttttttg agatggagtc tcactctatt gcccaggctg gagtgcagtg 4980 gcgtgatctt ggctcactgc aagctccacc tcccgagttt gcgccattct cttacctcag 5040 cctcctgagt agctgggact acaggtgccc accaccacgc ctggctaatt tttttgtatt 5100 tttagtagag acggggtttc accatgttgg ccaggatggt cttgatctcc tgacctcgtg 5160 atctgcccgc ctgggcctcc caaagtgctg ggattacagg cgtgagccac cgtgcccggc 5220 caggtgtttt ctatctattg ggagactgcc tttccctggt gctgggtgcg atcagttatt 5280 attttaggga gcagtggaac aacttcctga ccatcacctg atggttgtct gacgttcctg 5340 gggtgggggt gggggtctgc cctgcttatg tctgcctaac tacctactgt taacaagtta 5400 atcagataaa tttagtaagc tttcaaaagt ttgtataaaa ataatcctta gttaaattta 5460 gaacacaaaa ttaagttcaa gtgagaactt ttctaaacac agaaaacagt tttaactctt 5520 caaagaatac attgccactt actctaaaca acataatatc aatacaattg ttattccaag 5580 attattaaac atatatcaga aggtatgcag agctcagatg gtacttgtgg gtatgcctgg 5640 gcttgctctt tctttctttg tctgcctggt gaacttctct gcagactcaa ggacaaggtc 5700 ttcgggactc ttctgagaag tcagccctac tccttctcct ccacccgtca ctgccctgca 5760 gtattctgga gctgtggttc tcacacttta gaggacatca gaatgaggag ggcttattaa 5820 aacacagatt gccagcgcca ccccaggagg ttctgcttca gtagtctggg tggggctcca 5880 ggatctgtat gtcccacaag ttcccagctg actctgctgc tgcttgctca gtgactacac 5940 ttggagaacc actgccccag agaaaactcc tctctcgtct gtgctgccct ggcctattca 6000 gtcattttat tttgacttgg gccgagcaga gaatttctgt atcttctcaa gggtctgtga 6060 tcttctcgaa gagagagtcc tgttttcagg ccttggagaa gggtaatagc agagagttga 6120 ggggcttcct gggagagggc tgtggctgat ccagggctga ggagtctatc cagtaacaaa 6180 ggtgtagtca caggtctctg aaaactgcat cccaacccca gtccctgctg gactcacagg 6240 ctcagtggaa agtagagagc tgtaaacaca gaggtagtta aaaaaaaaaa aaagtaatgg 6300 cagaagctgc cctctctgcg accctgtaag aaagcatgaa acgaggcaga gaagcgtctt 6360 ttcatactcc cagacaaacc tcgcttttgt catcccaagg aatttaggcc attactcaca 6420 atgcctgaat gagatgatgg tgcccgacag agccgggcat catcaagggc tgtgctgccc 6480 aatccagtag tcattggcta catgtggctg tatgtatgta aatataaatt acttagaact 6540 aaagaaaacc acactagttt catttcaggt gctcagtggt cacagatggc tcacggccac 6600 cctgctggac agttcaactc taggacatgt ctatcattgc agaaagttca gtcggctagc 6660 actactggag ggacttggac aatgatgccg caagagcaag atggtacaca ggaaacccga 6720 tgtaacgtgt ttgtgcccct ctccctgcat gctgttctgt ccaagaattt gcaaagactg 6780 gcatacccca cagaatgatg cctgggagca tatgatgcct ctgcttctcc tttttcctgt 6840 tctcatgagc cagaacttta gtgccaagtg tggttggggt acccgtgagt cagaagaaca 6900 ctgttggagc tgagagtagg attgcccctg gtcaggggtg agtcactctc tggactccaa 6960 aaggtccaag ggtccttaac atggggctga atgcctgccc aatgccaagg ctgtcgagtc 7020 atactttttc ttttgttctt ttttttcttt tttggagatg gagtgttgct ctgttgcctg 7080 ggctggagtg cagtggcaca atctcagctc actgaaacct ctgcctcctg gtttcaagca 7140 atcctccccc tcagcctccc gagtagctgg gattacaggt gcccgccacc acgcctagct 7200 aatttttgta tttttagtag agatggggtt ttgccatatt ggccaggctg gtcttgaact 7260 cctgacctca ggtgatctgc ccgccttggc ctcccatggt gctgggattc caggtgcgag 7320 ccaccacgcc cagctgagtc atgctctttc tatttcggtc agtgttactt gtgcctcacc 7380 ttgcttcttc tgccgcagga acctcccctc ccctctcata cgcagcgtgc atgcctttct 7440 cttgtcattg ctctttgaaa gacagcctat gcatttgagt taggatttgg gaatttaaaa 7500 ggatggcaag tgaaaaagca gagttgggtt atctggatca atgatagagt ctccaagacc 7560 tggtctgggg ctctatattc agtaatgagg tttcctagcc tcccctggtg acacacccag 7620 gtctgataaa tctctcacca tagacaagtt tcccagcagt agggagctta aatgttcctt 7680 tacctaattc ttccataact catcataaaa tgggaaaaaa aattctaatt tcctcctggc 7740 tggctaaaac ctaagagaga tggaaggaaa aggtgttcca gggtgctttt gaggttgcac 7800 gtggacctga gttttagcag atgggccttt gcctgcctct gccatggggg ctcgcagctc 7860 ctcaggcctc ggtatcacag aggtcttagt caacgggtgg gtaacaaaac atggacgctg 7920 ctttggcaca cagggcacac tgaggggagg gagaacagtg taagagaagc atgctcagcc 7980 agatagttga aggacgtccc tcgtaagccc aagctgtgcc cacaattggg cttttaaaag 8040 gtctagaatg ggtggtggtg ggcaaccaga agtttgtttg tatgagagcc agggagatta 8100 attattttaa gaggacagga atgagggcac tataagcttg aattggtcag tgcaaggcct 8160 aagctgggat atgggaggaa atcccacatg catggcgctg tctgccagtc aggtttgtct 8220 cccaatccag attgtggagg gaaggaggag ggtgagagca gagctgctac aggcatcctg 8280 taaaagctgt ttgactccaa actccgtgaa acatggagcc caggcagcac actgattggg 8340 gaattctctg gccaactgtg acgaagtaag atgttgagca gaggcattct tccagagttt 8400 cccgcagaac ccacatggct ttggcccttg gagagctcca ggccatcaga gatggtgcag 8460 gaatggggta ggagacagag gaagccctgc aggaagccag caaaaacctc acctaccttg 8520 agaactcagc aatgccggaa gagattgaga ttcctagaga atggaggagc cgggaacaaa 8580 ggagaaggat gggatccagg aacaggccaa gagaaccagc tcgatgcttc ttcctctccc 8640 ttctagaaaa ttctgttcag aagccattag gtaaggtaga gcaaggcagg cctctgtagc 8700 tgagtgggga ggaagtagcg tgcccagagc aggagggtgg agtccaccgg ggtgagatag 8760 aggctcacac aagggcggtg gtccagtgtg aggttgccca tgtggagcga ggagggtgcc 8820 aacataggag ggggcagccc agcatgtgtc ggagaccaaa gcagggtccg aagggggtcc 8880 tgtccaggga ggatgtcctg gcacggagac tcagaccctc agtggggtga ggaggggtct 8940 acacagaagg tggcccaggg caggatggca gaactagagg ggtgaggaga gtgtctattg 9000 caagggcacc ttgcgcttgg agtcagtgcc ctggggaagt gggaagggca tccacatgga 9060 gggtggccca gggcaggatg ctgctgtcca ggcaatggaa ggaaggtgtc ctcaggaagg 9120 gtggtaccgc atgagtgtcc tacctgagca gagagaggaa ggtgtttcag tgaccggcag 9180 ggtggctgag aatcccactc tgctttgtgt cctgagcctc acagagcaca aggcatttag 9240 tagctgccca ggtaatggta attgttaaat ggatgatgaa ataaatgaga aaaatctgga 9300 ttcaactctc atcttgacca tatattagct atggaacttt ggatatgatc ttcatctcca 9360 tcagtgggat actgtgtatg aaactactca gaaaagctaa aggagctgat tttactccac 9420 ctaacaggaa agaaggctct gccattcttt gctgtgcaag cgttcctcat atcaaagaat 9480 ggcagagccc tctttccctt tgggtggagt aaaatcagcc tagccttccc ttagcgggta 9540 ccatgctgcc cagcctcagg tgcgtccttt gtgaggtgag aagtgtatgg agctgctgag 9600 tgatgtgtgg ctacagtgga tgcggagaaa ctcacctgca gggagagaac aggctgtggc 9660 cattggtgtg caggcctgtg gactttccgc atgcgttgtt cagcttattc agccttggtg 9720 gtctctgaga tctatggcag tgagcgtctg ctccctctca cagcaaacac cacactttca 9780 ctgaaaaatg aggctattag tcttgttcac agagcaccag gatccctccc agttctttca 9840 tgtgtttgtt tgttgttttt tgagacagag tcttgctctg ttgcccaggc tggagtgcag 9900 tggcgcaatc tcagctcact gcaacctacg cctcctgggt tcaagcaatt ctcttgcctc 9960 agcctcccga gttgctggga ttacaggcgc ctgccaccat gtctggctac tttttttgta 10020 tttttagtag agacatgttg tattttagtg gagatgttgg ccaggctggt cttgaacttc 10080 tgacctcaag tgactatggt tctacaatcc gagttctcct gttggaccag tcgagtgacc 10140 ttgggcaaat agcctcctgg cctgggcagc tgaggacagt gtgtgagctg tgttctgagg 10200 cctcaggcct cagaatttcc ctcctgacac tgtgggcctg agcagacaga aaggacaaac 10260 ttcctgccca gagcgtgtgg tctgaaggtg cctcggagac cctctgatca atctttgacc 10320 ccttccccca cacacactac agcagttacg tgtctgttaa aatacacgtt cataaaagac 10380 cacctactaa ataattttta agttgttatt ctaaaccaaa ctattttgaa cttttgtaaa 10440 tgcagttttt atttttaatt aatgacatta tctttgcagc cctgaatcag actttcctgg 10500 acacttttgg gtgttcttat ctgcatcaat ggggcctcag ttagcatttt aaaggtgaca 10560 ttgccccaga ttttatctcc accagatctt ctcttctgaa ctgcagatcc agatatcaaa 10620 cggcctcttg cacataatga cttggctatc tctcaggtcc tccctgtcca cagggtgggt 10680 tctcaactta tcaactccct cctctgacac cactcctccc ctgaaagggt cctcccactc 10740 ccctcagaga acagcagcac tcacagcagt cagcccctaa atccagctga tctttgtctc 10800 cattgccaat atcactgttc caggcaccat cctctctcgc tggtattact gcaaactgcc 10860 acccagctgg tctctccacc tccagccttg ccacgctgcc cccttgcccc gtccatgtca 10920 gactctacca cgctgacctt tggaaaatgt aactctgtat gcatcacttc cctactgaaa 10980 actctgatag gtcactatgc cctttaagat aaagtctgaa atcctcagca gggttgataa 11040 gcagctctat gtgggactcg cttttccagg ttagcaaggg acttccctga ttttagcact 11100 gaagtcctga attctcctta gtccttggca aactggatgg ctcaccactc ccctcttctc 11160 ctcattcctc tgcctcaccc ctaccccaca ctcaccctct gtctgtcccc tcagcagtct 11220 tcctcctgct actgtgaatg gtctctgccc cagccccttt gctttgtaac tttgagatcc 11280 ccctcctagt ctcagtgggc agatggcttc ctccatgctg tctcctggac accccgggtc 11340 aggtgactcg cccctgctgg gtggcactct tagttcccct tgtggcactt aaatgcgtta 11400 tttcaatcac tgggttaccg gaggtctcct tccatgactg tagatgctgc aggcagaagc 11460 tgagtcgtgt ttgcccccgt catcacctgt tgtctggcac aattgcctgc tgcggatttc 11520 agtggtgatt tttaggtgaa tcgtgatgca cccaggcaca gcctatacac agaacgttgt 11580 gtttatctgt tatcttggct ctgagacagg cagtctcaga aagtgaaaaa tagctggttt 11640 ataaatacat gataaaatgt tgacaatcac tcataattaa gtagacatac attaaaataa 11700 taacgttcac ttttttcgtt gagacagagt tttgctccgt tgccaggctg gggtgcagtg 11760 gcatgatcat ggctcacggc agcctcaagc ttctgggctc aaggtatcct cctgcctcag 11820 cctcctgagt ggctaggact ataggcacat gccaccaaac ccgactaatt tttttttttt 11880 ttttgtagag atgggtttta ctgtgttgcc caggctggtc tcaaattccc agcctcaagc 11940 aatcctccct ccttgacctc ccagagtgct gggattacag gtgtgagtca ccatgcccgg 12000 cctaaggttc attttttacc tactagattc ataaaggtca cacaatgtga agaagcggag 12060 gacaccagca ggcgctctcc tccctggggt agaagcataa atctgcgaga acccttgaag 12120 agtaacttgg caatctttcc taaaagctta cctgtacata gttttttttc acagtttcac 12180 tcctagaaat gtattctaca aatactctta gagatttgta cagaaaagag caaacaagaa 12240 tattcaacac atcattgtta gcaatgaaaa taaaagggaa aaaaataccc tacctatcca 12300 tcaaaaggaa actcgttaaa taaattaggc aagtccttct aacagagtat tataaaggaa 12360 ttttttcaat gaggtagatt tacataaggt tatatgaagc aatcctcaaa gcagggggag 12420 ggggcaggaa atgaaaaagg tctacaattt gtttattttt gttgtaattt taaaaggaaa 12480 tatgcacatg tgttaatatg cataaaaata tttctggaag aatacacaag aaactcgtag 12540 cagtaattac ctctggggag agagactggg atctgggata ggagagaaat ttattcattc 12600 tatattctgt cttaagtgtt taaataattt attacaggca taaattcacc cttttttttt 12660 ttttttttga gacggagtct cgctctgtcg cccaggctgg agtgcagtgg tgccatctcg 12720 gctcactgca agctccgcct cctgggttca cgccattctc ctgcctcagc cttcagagta 12780 gttgggacta caggcgcctg ccaccacgcc cagctaattt tttatatttt tagtagagac 12840 agggtttcac catgttagcc aagttggtct tgatctcctg actttgtgat ccgcctgcct 12900 cggcctccca aagtgctggg attacaggtg tgagccacca ttcccggcca taaattcatt 12960 tttcaatact acaaaaagaa aactccgtgt tttttttttt ttaaagaaga aaaaagctag 13020 ctagaaaaaa gcatctgccc gaggttctag caattttcct tccttccttc ctttttccat 13080 cttttctttt ttttctttct ttctgcccat gctctcctcc tttctaagaa aactgtcttt 13140 ccagaatctt ctaacaatat taagtaataa gattagacta gctcttcgtc tctgagctgg 13200 gagtccaggc tggactgggt gagtttaccc ttgcgtgagg ctgagtgcta atgtctctca 13260 cttactaatg gggtaccttg cagcctgcct ttcatcctcc tgcccacctt ctccccagcc 13320 atgtcctggc atcagctgca acagatccca gcttctcact cctcccactt tctgctcagg 13380 ggctcctctg ccaccatgat gtgagatgct gaggacactc attttgtcat tgtgatatgt 13440 ttggaaacct ggctgtggga gagggttaac aacccccggg atgacctgtg atccatgggg 13500 tcatccctca cagcttgcta ggggtcccca gcggtatcga gctccagttt ctcactggcc 13560 tgaccagctc aataatttac cttggttggc ttgtcctctt tccgtttgac tcttccgagc 13620 ctctcactcc tgtttcttgg gatcactttt caaagtaaac caccatgttg tgctaggctc 13680 tgcttgttgc agaaacccag gctaagacac catctttcat cactcctgga gagttctgga 13740 gtccttgtag acctgtggat taagaccaca cttcattcaa agagatccaa caattttccc 13800 tgggagttcc tctctctcgc tttctcttcc tgagatgtaa cctttcccct ctaggtcctt 13860 aggcctgcct ttcttcctct ctattaatgt gaggatggca ttttgctttg tgccccccca 13920 cctcaaattc tgtattgaaa ttcaatcagc aatatgatat taggaggtgg ggcccttggg 13980 aggtgattag atcaccacct ttgggatagg atcaatgccc ttattaagga gacaccagag 14040 agctgcctgg tctcttccac catgtgaaga cacagctaga aggtaccacc tctgtaccag 14100 agagtgggtc ctcaccagac accaagtttg ctggctcctt gatcttgaac ttcccagcct 14160 ccagcactgt gagaaataaa ttcctgttgt tcataagcca cctcgcttgt agtattttgt 14220 taaagcagcc tgaatggact aaggcacctt tataaaccta ggcattctat tctaaaattg 14280 ccttccagtc caacagaagc atgttataga ttctccaggt agaagcattt gttgtaaaaa 14340 ttaactgtac ccttgacatt gagatcatct tgtatcaatt ttagatccct gaactctgat 14400 ttgatgattt aaaaagcagg agaacctctg aatctaactc attccagtcc ctgcggtgga 14460 aggcaaacat agttcactca tttggaaacc aaggttccct gcacagaaag tgccaggcca 14520 acccagcgag ccctgatgca aggtcactat ttattttgtc atcctgaggc gagagttcct 14580 tcaaggggct gctgttggct ttcaaacaag cctggaaaat tgtctggtgg cctctttgat 14640 cctgcccctt tttctgggtg gtgctctctc ttttctctgt gttccacttt caaaataaac 14700 catctcagtt ggctgtgata aattcagtga aggaaatttc aagttgagaa tggtgagaag 14760 acctgcagaa gggaagctat aaatagccca cttttaatgg ctatagtaac ataattccct 14820 ttacattact gtctgccatt aagcaataag taacattgta acttgaaaat cggaccaaaa 14880 tagattgcac catctaccca gacccaatat ggtatgtgta aatatgcaac actgccctat 14940 tatttataga tctatgattt tccttatgaa acggattcat ttgggtgctc tgtagacctg 15000 agttaacttg atccaacaaa atccaacttt gtcatagaaa cctacaagtt tagagcaagg 15060 gggactttta ggaatcacgg agttgaaagc ctgtcctttg cctaagctca tgcagggaca 15120 cagggatggg tacatgtgag aaggaagtag agactgattc caactgaaca cctggagaaa 15180 ggcctcggat tctcagattc aatgaaaggg gccttcacat gcctttgtta tctatcacaa 15240 catgagatct ggaggctgca atcaccattg ttcagtggag gaaataggtt cacagagtga 15300 agtgacttga tccaagttac atagtaaatc aatggcaagg aattggactg gaacccaatt 15360 ccaacttaag gctagtattt ttcctttcat agtggtagct ccattgtttc tggcttctag 15420 agtcttgggc tggtcagctt tgattgacac gtccacagta agagtcccag ccctgccccg 15480 cctcccacct atacctcagc acctcagtag gtttctgtga cccctccctt tcttagcctc 15540 aggtttgttc acactacaga tggggtgagc caccccaagc ccctatcacc acatcgtctc 15600 ccactcctgg ccccaaatgc tttcccctgg ccatgctcct ttcttattat tctgaacccc 15660 ttgtcagttg ttttctgtac tttatccctg aatagtcctt tcaaaacaga acatttacaa 15720 tttccttctt taagaaaaga gtacttaaaa aaacaaaaac gaaagccacg tttgtgattc 15780 tcgcttcttc cattacttac cttctaattt tccaagtctt ggcttggcat tcagggcccc 15840 ctgtaattag gcccctgcaa tgtggatcac cttctcccta tccctgtgtt gcttgtacct 15900 ctattacaac attgcacacg ctcagccctg ctacctctat tacaacattg cacacgctca 15960 ggcctgctac ctctattaca acattgcacc tgctcaaccc tgcaatattc caactaaaga 16020 gcatgggaca ctgaattcgt ttttatgtcc agtagaacat ctgccacaca gtcacgcaca 16080 tagtaggtgt ccagtgacag tgtattgaat ggaatgggct cattcctgct tcctgcagca 16140 tggtccctat ggcctgtcta gagcacatct ttctatctgg gggcaagttt gggcctgtca 16200 ccccctgcag tagacactaa cacacaaagg ggtgagatta gcccctgtgc atagttccaa 16260 agaacgagct ggcctaaata atacttctga gtgtgctacc agtgcaactg agttatttct 16320 taaaccatca catccaggtg cctagtatgt ttctaggaac tttatctgaa agcatcaatt 16380 tctgtcactg atcccccaaa ttgtaattgc tcaagaccaa gtgaggacta aaactccgca 16440 ggcatgacag ccctgtgttt tggtgctaca tgcgggggga ctgaatgtct tacagaggag 16500 cttacagtct aatggggtgg ggtgggcagg gaaacaaacc tgcagagagc gacaataggc 16560 aagacaagag catgaagaga gacactgtgt atgggtaggg gtggctggga gaatgaggat 16620 tacatgacag agtttataga aagtgcctgg cacatagtag gtgttcagta aatggtaacg 16680 agtcatattc tcactaccac acaagcagct gggttcacag aggatcaagg cctgtgcctc 16740 cctctgactg ccatgcctct tcctccccta tcctgcccac tccctctgct ccggcctggt 16800 cttctgatca tgaggaacat gccaagttct ttctttcccc agcagggaaa agctattcct 16860 tattccagaa atctgtgttc ccagcttagg gcaagactgg ctgctgcttg ctctttaggt 16920 ctcagaataa atgccacctc cccttgcctg accactgcac tgccctgccc cagagttatt 16980 ctctatcaca tcacactggc tagttccttc tttgcaatta ccagaagctc taaaaatttt 17040 gtttctttct ttgcttgttc cttgtcccac taggcttcag gctcgagaca gagaggaacc 17100 gcctctgtgt ttttcactgt cgtgtctcag tgctgggagt gtactccatg tggtcagtgt 17160 gtgatcaatt taactgtgcc tgagggttct gagaagacct cacaaatgaa ggtacctttg 17220 accagagcca cggagagggg acaagagttt acccaccagg cgctgcaaag ctgaggtggc 17280 aggtcaggac ttccagtgag aaggaggtac tggtaaagga gactgttatt atgagcagct 17340 ccgtccagga gaagccaggg ttcctggtcc aaaacagcac cctaggttca aataggaata 17400 ccctggggtt ggaggtgagg gaagggtggt ggacagctca ctcagctatc agaagctgag 17460 ggataagtcc ccttcctcca atctgggctt tcttagcagc cttttgagct ggaatttgtt 17520 ttgttttgtt ttgtttatgg tgggacctac ccactgtgca gggaggatct tatcaggtgg 17580 ccaagcttgt tttttgtttg tttgttttga gatggagtct tgctctgttg cccaagctag 17640 agtacagtgg tgtgatctcg gctcactgta acctctgcct cctgggttca agcaattctc 17700 ctgccttagc ctcccacgta gctgggacta caggcgtaca ccaccatgcc cagctaattt 17760 ttgtattttt agtagagacg gggtttcacc atgttggcca ggatggtctc gatctcctga 17820 cctcatgatc tgcccatgta ggcctcccaa taagcctggt ttttggaaca atacaaataa 17880 tgaaaatttt aagtactgac atttattgag ctcctattgt actattttac acacatctgg 17940 tttaagccac agccactgca caagattggc atttttcccc atttccagag gctgaaactg 18000 agattgagtt tcatgtccaa agagtgagta acatgtgtaa agtcatgggg ctaggaagtg 18060 gtggatggag tttcaaaccc agctgtgttt gaccctgaag ccagggcgct aaaccacaat 18120 cttttttctg gccagtgtat ctcacaggtg aatcaattca ctgggtttgg cgcattccct 18180 tgtgggctga gtcaccataa gtcagactgc ctgaacctgt tcctctctgg gaggctgata 18240 gaaacctaat ctctaaactg acaatgccag gggcaggact ctggactttg gtaaccccat 18300 gatggggtgg ctccctactc tcccactcag agctgcagat agcttttctc caggacagca 18360 ggactcaagg gtgctatggg ggttagttat tgcagacatc ttgctttgct ttgctgtaga 18420 gtggggtggc taagagcttg ggtagaggca gacagactgg tttgaaatcc agcctttgca 18480 cttcgtagct gtgtgacctt agcttgggca agtttcttta ccgctctgtg cttcaactct 18540 catctttaaa atgaggctga gaacagtctc atggtgctac tgtgaggatt acgtgaaaaa 18600 acgcgcttgc acatagcaaa ccctcagcaa tcattagcct ttatcattgc tgttgttgtg 18660 actggtatat atatatatac tttttttttt tttttgagtg gagtttcact cttgtcgccc 18720 aggctggagt gcaatgtcgc aatctcggct cactgcaacc tccgcctcct gggttcaagt 18780 gattctcctg cctcagcctc ccgagtagct aggattacag gcatgcacac cacgcccggc 18840 taattttgta tttttagtag agatggggtt tcaccatgtt ggccaggctg gtctcaaact 18900 cctgacctca ggtgatccac ccgcctcggc ctcccaaagt gctgggatta caggagtgag 18960 ccactgcacc ccgcctgttg tgaatagtct taaggggagg cgtagtggga tgtaatgggc 19020 tggagtccta ggccaccact ttttagccat gtgacctttg agatgaacta ttaaacttca 19080 tcccagaatc tttctaaatt ctccaaagtt aaagatgaga tttaatagct catctattaa 19140 agatttctgg gatggcattc ttaaaattaa gattagcttc tgttaaggaa ttagaaaaca 19200 ccagaggtag ggaatggtcc ctgtcacata tagacagcat ttgccctaaa ccatgctctg 19260 gtcaagagga ggctgaggac ttctgagcca tttgcctctc atcagaacgt cctgggtgta 19320 gtgtcagaga gtggctgtat tggcttgtct gaacagctag tgtgttgctt tggtttgagc 19380 tgaaagattg ttctaacaaa ggtgcatggt gactatggtc agcataggcg ttaggagagg 19440 aggggccgtc tgtgcacact gtcctgggtg tgcccatcct caggagctca gctgtgtagt 19500 gtgtggcagc ctgtccccct gactcccgcc ggtgaggttc acagatggtc agagctccca 19560 ggtgcggctc taaagctctg gctctgctgc cgtggcccca ggcaacctgg ctggctcatg 19620 ggcttcagct tctcacatgt ggaagagcac agatcatcct tcaccccagt atcccggtag 19680 ctgacctcag actttctgag tgtgagttga cttgagtagc cctgagatgc tgacgtcctc 19740 tgagtacatc aacaacaggg agtttctggg ctgcaggctg agaacccgtg tttgtcacaa 19800 ggcggcccca cagagttacc accactctaa ggccctgcca gagccagcaa cagattattc 19860 cagaaggcac ctgtctccca atcaccttct ctatctggaa caacacctcc ctcagggttg 19920 ggtaaagtat taaatatctg tgccttgcat acactcactc agtgctcaac aaatgctggt 19980 tctttcccag tttctgtaat ctgtatgacc tatcttgacc aagagattgt catcatcctg 20040 aggcccgggg cccaggctgc tgttgcgctg gcctctctcc ctcactctcc agtaagccct 20100 gtcccaggct ggcctctccc tccggggctg tcttatccac gcttgggctc caaccacctt 20160 gacccttctc cacctgtcag tcacgcccca ggtgttccct gagtcacgca acagctatat 20220 agtagctccg cagaccaaca gcaggccgac agcgtagcac ctgagttcta gatctaccac 20280 tgttcatgcg ggacctggca taaagcattc ccacgtctcg gcctccattt ccccatctgt 20340 gaaacgagag cactggtcag ctcttcacat gcagcgtttg tgggatgaat ccttccatct 20400 gtccatccat cccgccaaca tccatgcaca aacatttagc acctgctgca tgctgtcagg 20460 gactatggca ggaaaagagt tgaaacagac acgtcccagg cctccagccc ctcacaccac 20520 ggagaggaaa cagatgcccg caaaggagga ggcacccctc agggggccag cgctgcgaca 20580 cggtggaggc agggaggccg tctctaagca gcctgcgagt ccccgcgctg caccgtggct 20640 ttgaggagtg gcgggggccg aggggccggt ctctcttccg ggggagattc ctcccctcac 20700 cccggcatta ctcagcgccc tgaactgtct gcctccctcc agccggccct cctcgtcttc 20760 ctggagcgca gcacaaaggt cctgttgtgg ccgcggcccg ggccgcgggc gagcctctct 20820 ggatggtggt gactcagtct cttgccattt cctttgtgcg gctccggggc tcctcgctgg 20880 gagcggagtg tgtctgcagg gctgggggcg ggagccggga cccacagccc gacagcgagc 20940 ctttcatgtg ggcagggggc ttcccgcacg caatgcgaac ctacgcctgg agcttcccaa 21000 agacagcgtc cggcgcagga acgcgagatg ctggccgcct cgcctctggc ccccgcgagc 21060 atcaaagcgc gtgccgtcga gggggcacgt gtcccccatc gggcgcgcct ctgctcctag 21120 tcccctgaat gaacacatcc ttatgaaaag tggaaattag ccgccgaagg gaagggcccg 21180 gagagcttgg gaagcgacct aggctgccag cctcccggcg ggtctttggt cccagctctg 21240 atgacctgtc agcagccgca ggacctgcgc ttaaaggcgc ctctccaggc ctggctcagg 21300 gtggggctcc tcgtgctcag caccctggtc aaggttaggg ctgggtgtgc gctggaggct 21360 tggagtgcca gggcacccag tgaagagcga atgaatgaac gagtgaacac cggactgggg 21420 gcctgcagac ggttcttcgc aggttaatta gaaggcctct agcaagctgc agcggaggca 21480 tttcaggcat ccttcagaga ggaccctcgg cctggctcct aagggcccct ggtctggctc 21540 tcaccccctg ctctggtggc atttctgctc actcagcctt taccctttac acgccagccg 21600 ctctgaacag tttattcttc tgggagcaca tcatgttctt gctcacatcc aggttttgcg 21660 taagctgttc ctgctgcaag gaaaaccctt cctgtgtcct cctcaggtga gagctcccgc 21720 aggcagcttc tccccggagt ctggcgtaag tgttcctcct ctgcacgcct ctgaggacat 21780 ttgcaaaggt ctgtcatagg gcttaccacc ccgttacctg tttgtttcca ccagggagtg 21840 cgctgaagct gagagggaat gagtgagtga atgaagggct tgagaaagga aatttcttca 21900 ccctccagtg ccctctgggt gggtattgag acaagctcta caggaagcct aagaaaacta 21960 actgctctaa ttctgtcctt ccttttgcaa tgtttaggca actcctgtgc atctgtaggt 22020 accattgtga ggttactgcc ctggactggg gagagatcca cacacgcaag agtgcatctg 22080 gcatcagtat gtaagagtca aaactgacac acagttcttc atctcatgga aatgaaaaca 22140 tgcatggccg gaatgatctt atacctgctt ctcttgggcc aggtcaccag gctggccctg 22200 agaagtatgt gatggcatgg agaagaatcc tcacacatcc ttgcagttct ctaggatttg 22260 caaggcattc cccccattgc tggactcact ggatttgagt aggcctgtct gcccctattt 22320 tagagatgag catatacacc ttacaaaaac tgagtcttgc tcaatgtctg gcaaagaagt 22380 cttcctttat ccaacaatcc tgagagtcta gcgggtgttg ggcaccataa agatgaatga 22440 ggtgcggttc ttgccaccag gcagtgcccg ggcttgtcag ggagacccat gtggagcatg 22500 acaattgcta ccttcttgat acgggcaaaa ggatgttgag tccagtggaa ggagaggctt 22560 gtctggctgt gagatcagca aagtcttcac agaaaaggag aattttaaat ggggccttga 22620 aggggaagtg tctcctggag atggagagaa catagcgagg agagtgcggt gaggtggggg 22680 gtggcagggg aagcacatca ctacgcggtg cttagggccg agtctgagcc aacctgggag 22740 tggcactcag ctcccccagg cccccgagat gcatgttcag cagcatccag cggcctcctg 22800 tgaagcgact gggagtccac agagacaaca aaagcagatg tagtgatgtg taaacttgaa 22860 gtttctagaa gttcctttgg gccccaccaa atctctgtgg caatgaacca atcccacatg 22920 ttcctgtggg taatgctccc agagggcatg tgactttggg catcattatt ggctgaaaaa 22980 ggaaactggg gtagtagtta gagagtgcta tgaactgaat gttgtgtgcc tcccaaatct 23040 gtacactgaa ctccaaatcc cactgtggtg gtattaggtg agggggcctt gggaggtcat 23100 taggtcctga gggtaaatcc ctcatgaatg ggatgagtgc cctcacacat gagaccccag 23160 agagctctct ggcggtcttt ctaccatgta tggctgcaat gagaggtctg cagcctgcac 23220 ctggaaggag gccctcaatg aacctgacca gactagcatc ctgttctcag acttctggcc 23280 tcccaaactg tgagaaacaa gtttctgttg tgtataaacc atccaatcta tgatagtttg 23340 ttatagtagc caaaccgact aggacagaga ggatgtaagg agccagtgga ggactctttt 23400 aatggagaga ctacagcatg tctcaggctg aatggtccag tagggagagc aaaaacagtg 23460 cccatgcatc accctgaggt ctcacccaac cctgctggaa ctgactttag tgccctcttc 23520 cagtgttccc cgcatgacct ggtgggtgca cacctggctg cttgcattca caccgtccct 23580 ctccacttct tccttctccc cagctctctt cctgtcaacc ctggcattgc ctttgttggc 23640 tactgagaga agaccagaaa tatccatcta gtcagacttg cctgctcctg ggaagaaaac 23700 aaaaatgcaa agaaaaggtt ctcagggaga ttgagccaac ctgggagtgg ccctcagctc 23760 ctccagtccc cagagaccca tgctctgcag catccaaggg gctcctgtga aactgttggg 23820 aggccaatga cactctgtcc cacgttgtgg atctattttg tggtctctgt atccttcact 23880 gctttttgtg gacattattg tattagattc ctttggaaat gatgatccag ctaatggcca 23940 gttagtagga aacatcacga ccctcccccc aaattccagc ctcttgctga aagggtgggg 24000 cctgggaaat catatggtat tgctcctggt caccacagac cagtggtggc tttgggccaa 24060 attctggccc agccaatccc ccccaccttt tttttttttt gagagagaga atttgaggta 24120 agagacacag agactcaggt taggaggatg cttgaactga aaggtcctga gacagcagga 24180 caggagctag taccatgcag aacacagcag gagccacagg caagcctgaa ctgtgggaga 24240 gagaaaacga agggccttcc agagaggtcc agtctgccaa gaggagaaga gagttgacac 24300 gcagaaagag ttaggggtga caagaacccc cgtagcccct tgaaggacac agagaggaga 24360 tcttttttgt tcttttgtga ttcatccttt ctcacttcct gtccttggag gtcaacaaca 24420 gacccctgta tccttttaat aatccctctt ttcatttgaa attgttccag agggtacctg 24480 atccttgttg ccagcatgcc ctgaataaga aaaatgctca aaccaaacac tgagtctact 24540 gagtctatgt gaattaattc ttggaattcc ttggctcaat tcaataaaca tttcatgcac 24600 aatttttgtg tgccaggtgc tagaggcatt ctgagaaaaa ctgagaccca ggagctgtcc 24660 tcagagagtc cagtaagatg tggtctgata agacatgttt ccatataccc agaatacaag 24720 gtagtttgct aggagcactg caagagaaac gcagatggaa ggctggagtg tgtactgcca 24780 ctgtggaagc aggaggggct tgagggaaga gggccttcaa gaatgggtgg aatctaatat 24840 tggaaagggg aggaagagtg gaaagtataa gaatcagaag tctggttgca ggatggggca 24900 tgatatgggt gggacactgt aaactgcaca gcgtggaagg aatatggagt ttagaggaat 24960 aatgttagat gagtctgtaa gacgggcttg actgggatta tgaagggcct taaaggtcaa 25020 gccaaatttg ttatcataga atcataagaa ggagaagagc cttagctgtt gtctagtcta 25080 acttaggtaa tttggttcca gttcctctta aggtggccac catgacagac tgaatctcaa 25140 gtactcatct gagatacagt catttcaatg gtagtgactc agaatttact tttctttttt 25200 tttaccccag caaaatattt attttagaaa ataggattat attatttgtt gctctccaac 25260 ttgctttttt tggacatctt ggacatcttt ctctaccagt acatatagtt ccatttcctt 25320 ctttttattt tatttacttt attatttttg tagagatgag gtcttgccat gttgcctagg 25380 ctggtctgga actcctgggc tcaagagatc cactcacctt ggcctcccaa agtgctagga 25440 ttacaggcgt gagccactgc agatattttt attttttatt ttcatttatt tcaatagttt 25500 ttggggagca cgtggttatt tgattacatg gataagttct ttagtggtga ttaccgagat 25560 tttggtgcac ccatcaccca agcagtgtac actgtaccca atgagtagtc ttttatccct 25620 cgtcctcctt ccccgctccc ctcacgtccc caaagtacat tgtatcttat gcctttgcat 25680 cctcatgaga ttacttttct atctttaaca acttaagagt tctttccaga agagtcctct 25740 tactacgagg aagagtgtta gagcacaggg aactgggcct agagagtctg cagcaaattg 25800 tctcaaatag cagcttaaaa aggtaaggaa cagaaaagaa acactctcta tctatgtgct 25860 ggcctcaggc acagtgcttc tagatggtag aacatctgtg aagtagaaat tacaatcact 25920 tttcaggtga gaaaacagga gctgtaggga ggagtcggac aggtccccag gcccagcaac 25980 tataccaggt gaggcaggaa tgtggcctcg tgttgaccag attccacagc cacgggcttc 26040 catccctctt ctctgcttgc tttaagacta accaccctgg cttcaagtaa gtatcactca 26100 caaaggaatt tcaaaaagac atgcacataa attaatggct gatggctgta ggtggtcgta 26160 tgggaggaac cgattataac attgtatgaa cttagcaaag ctctaaacca tagcacagac 26220 atttggcaaa atggttactc tttttcaatc atccaaggac tcagtttata ataagccttg 26280 agcgagtccc taaattccaa agcccttagc atcttccagg accctcttga gaccacacag 26340 tgcttccagc ttccggaaac agcagatgct attgcttcca tgagcaatgt cagcatttaa 26400 tacacaaggg ggaacagaga aagaaaccta tatggatggg gagcagggag gaggggcagc 26460 actggatcct ctcctgggcc ctgtccagct cgacattcct gaacagagcg tgctgttccc 26520 tctcctgatg ttggcagctt agaatgcagg agccttagat gggtggcctg gaagggaggc 26580 cagcagggag aggtgacctg gaagtgagga agctcaggag ggactgatgg taattggagg 26640 ggcaggcaga gagaggcaga tgaagaaaca gccgaggcct gtgtgaaggc tggacccaac 26700 ctgcgtccaa gcagaaagtc cagagaactt agcacagctt ccaaagcttc agagtacatc 26760 agaactactt gggaagtgcg tcaaactctg gttcctaggg aaatcctcag agatcctgca 26820 tctgcgatga ggcccagaag tggtttttgt gaccagttcc aaggcgactt catacaggca 26880 gtccttgggg acactggtga caggatttcc ctctctggac cttggtgtcc tgctctgtaa 26940 ataaaggggt ttgtcaaaga cggtttctgc tttctctgtc agctccaaca tacagcttct 27000 caaaagcttc caaaaatccc cttacccaag cttgcagccc tcatcacctg tctcaagata 27060 atggtttcct attcttttta atgtataagg cagacaggtg gtcatgtacc tgctcagctc 27120 ttgaaaagga cctacatgat agactctagc aactccacct cgtctgccca ttttggggga 27180 gagtaaagcc acgtcgtgtg cgttcacata ggcatccaaa tgggacagac ttcctctctc 27240 tggaggccgt ggctccaggt caaaacaaaa ccacttccag gtctcaggtc acaggatcct 27300 gcagaatgat ttatttaagg aagaaagctt caagggctcc agagaaatta aatgtgtata 27360 tttccccagc aattatgcac gtcctttccc ttgaaaaata gttcccatgc cctgcctgga 27420 agaaaagcca gattctccat gatgctgtgt tccacaggct tctagaggtg ggggggctgt 27480 gattttctaa caggagaagc cacatgaaag tcttcagcag ctttgcgctg tttctgctgc 27540 agcacctctc agggcagact ggagaatcag ggagtcttgt ctggaaaaac gagacaggct 27600 gggcctgaca cattgatttc tggttcaagt ttcccagtga aatgtgaagg aggaattttc 27660 cacttcttgt cctgattcac cttggcgaac cagtctttgg agtcccagac tg 27712 <210> 26 <211> 1863 <212> DNA <213> Homo sapiens <400> 26 cttcctcggg gtttgcttcc aggcctgact tttactcccc tttctaagtg tgcagatggg 60 atgtgcttct ccacaggagg ccccacggct tccccacccc tcagaggagc gccgtgcgtg 120 cgtctgtgtg gaggattggc agctcctgca gtcggccctt ggtcctattt ggcgacgcct 180 ctgccttccc cttaattata cagtcatgag ccgccctgga atcacggcag ctccggatgg 240 atcctggatg ccagaatgca gcctcagcac ggggctgcag gacaggagtg agcgaggggc 300 tgcagagccg gcggccgcgg tgggcaccat ggagggggct gccctgggca gcacgggcat 360 gagtctcaag gcccaggttt gagtaacagg tgttgagagc ttacttactt ttcctgagac 420 acagtttcct catctcgaga gcacggaaaa tcattctaac ttcagaggat tgttgtgaaa 480 gttaaatgag attaaagagg taaagcccat gacgtgctta gctcgtgctt ggctcttggt 540 caatgccagt tagcgctgca ttttctcccc tctccctccc tccttctctc tttcttttct 600 tctattctcc attcctgttt tctcccccac cccactcccc aaagctctgc gttgagaacc 660 agatgctgtc tggtgggtta gggccagagg aggaaaagct gcccgccgtg ggctgcaccc 720 ataccctctt cattccaatg acatgagggg aggggaaagg acagaggtag actgtcctcc 780 cctacctcct cctaatacaa atggaattcc tggaactgga aaacaaagaa tacccccata 840 aaaataagac agtacttctg gtgcggtgta ataaagggga aagtaaccct caatgtcagg 900 aaactccgca cctcccagct catatttgtg tggaggaaaa gttaaatatt aatttggact 960 caactgaatg tggacacaaa caatggtcac caagtcccgg aacaggttgt gtgagcctct 1020 tcaggggttc atccagcgct gttttggaga aatctctatt tcaatttatt cctatacgtt 1080 agttactgaa aaacaacaga caatcgcaaa agcaagttgc ccgttttgtg ttccttgagc 1140 ccaatcatga agtgccgtcg tgactgggcc tcatgacaaa caacttgtaa caagtaacaa 1200 cagagctcag gtcccagacc gcactgaagc tctgtgagac ctctcctcat ctgtgcatga 1260 acgagtgtct gactctggag cccagcctgc tgcttcccag tctggtggtg aatcctccgt 1320 agtctgatgg aggtttgctc ttgttgccca ggctggagtg caatggcaca atctcggctc 1380 actgcagccc ctgcctccca ggctcaagca attcttacgc ctcagcctcc tgagtagatg 1440 gaactacagg gcatggactg gaactcccaa tacccctgac atgggctgag tcaacgtggt 1500 catgaacatg tgacaggagg cagcagaagt tgcagagaag agtgaggcac gtttgaaaaa 1560 ggctgaaaaa tgtttctgtc caggcaaggg tgtgtgctga atgactcaag gattttttgg 1620 gcaacacaaa ccaacacgag ccgtgtgagg atcaggtgac agctgcccaa aagctgacac 1680 aaggaacaag cctggaggag tgaggatggg tgctgtgaag gaggttgtgc agctgggccc 1740 gcagtcggac ctggtgagat cagaggaggg ggtgccacca gtctgtggac gaagatgaga 1800 agctggaata gagcagaaaa caggaggctg ccactctcca tctttcccaa agtcactcca 1860 gga 1863 <210> 27 <211> 1402 <212> DNA <213> Homo sapiens <400> 27 ctgtctcaag cctccaatca acagatcaga cagcttgtac tcacaggcca aggacacgtg 60 gaaagaggct caattttcta gatgggtggc aacagccatg atcttctgtc ctctgggtcc 120 ccacaagcct ggatgaactc aagatctgac tcagtggcac agtgaggaga cctttgaggc 180 ctcagtgacc atccttggac ttcacctctc acggctttca ggcagagagg ccctcccatg 240 cccacaacag gctgagccca gccttcctcg gggtttgctt ccaggcctga cttttactcc 300 cctttctaag tgaggcagcc atgactggcc acttcatgtg ctcctggaga agggcttgca 360 ccagccgttt tcaggaaagt caagcagctg ttgactcctg agtctgggtg aatttgtgtg 420 aagagcataa ggcgctgttt cttaaccaaa acgcttcctc ttgcagtgca gatgggatgt 480 gcttctccac aggaggcccc acggcttccc cacccctcag aggagcgccg tgcgtgcgtc 540 tgtgtggagg attggcagct cctgcagtcg gcccttggtc ctatttggcg acgcctctgc 600 cttcccctta attatacagt catgagccgc cctggaatca cggcagctcc ggatggatcc 660 tggatgccag aatgcagcct cagcacgggg ctgcaggaca ggagtgagcg aggggctgca 720 gagccggcgg ccgcggtggg caccatggag ggggctgccc tgggcagcac gggcatgagt 780 ctcaaggccc aggtttgagt aacaggtgtt gagagcttac ttacttttcc tgagacacag 840 tttcctcatc tcgagagcac ggaaaatcat tctaacttca gaggattgtt gtgaaagtta 900 aatgagatta aagaggtaaa gcccatgacg tgcttagctc gtgcttggct cttggtcaat 960 gccagttagc gctgcatttt ctcccctctc cctccctcct tctctctttc ttttcttcta 1020 ttctccattc ctgttttctc ccccacccca ctccccaaag ctctgcgttg agaaccagat 1080 gctgtctggt gggttagggc cagaggagga aaagctgccc gccgtgggct gcacccatac 1140 cctcttcatt ccaatgacat gaggggaggg gaaaggacag aggtagactg tcctccccta 1200 cctcctccta atacaaatgg aattcctgga actggaaaac aaagaatacc cccataaaaa 1260 taagacagta cttctggtgc ggtgtaataa aggggaaagt aaccctcaat gtcaggaaac 1320 tccgcacctc ccagctcata tttgtgtgga ggaaaagtta aatattaatt tggactcaac 1380 tgaatgtgga cacaaacaat gg 1402 <210> 28 <211> 3679 <212> DNA <213> Homo sapiens <400> 28 gaggcagcca tgactggcca cttcatgtgc tcctggagaa gggcttgcac cagccgtttt 60 caggaaagtc aagcagctgt tgactcctga gtctgggtga atttgtgtga agagcataag 120 gcgctgtttc ttaaccaaaa cgcttcctct tgcagtgcag atgggatgtg cttctccaca 180 ggaggcccca cggcttcccc acccctcaga ggagcgccgt gcgtgcgtct gtgtggagga 240 ttggcagctc ctgcagtcgg cccttggtcc tatttggcga cgcctctgcc ttccccttaa 300 ttatacagtc atgagccgcc ctggaatcac ggcagctccg gatggatcct ggatgccaga 360 atgcagcctc agcacggggc tgcaggacag gagtgagcga ggggctgcag agccggcggc 420 cgcggtgggc accatggagg gggctgccct gggcagcacg ggcatgagtc tcaaggccca 480 ggtttgagta acaggtgttg agagcttact tacttttcct gagacacagt ttcctcatct 540 cgagagcacg gaaaatcatt ctaacttcag aggattgttg tgaaagttaa atgagattaa 600 agaggtaaag cccatgacgt gcttagctcg tgcttggctc ttggtcaatg ccagttagcg 660 ctgcattttc tcccctctcc ctccctcctt ctctctttct tttcttctat tctccattcc 720 tgttttctcc cccaccccac tccccaaagc tctgcgttga gaaccagatg ctgtctggtg 780 ggttagggcc agaggaggaa aagctgcccg ccgtgggctg cacccatacc ctcttcattc 840 caatgacatg aggggagggg aaaggacaga ggtagactgt cctcccctac ctcctcctaa 900 tacaaatgga attcctggaa ctggaaaaca aagaataccc ccataaaaat aagacagtac 960 ttctggtgcg gtgtaataaa ggggaaagta accctcaatg tcaggaaact ccgcacctcc 1020 cagctcatat ttgtgtggag gaaaagttaa atattaattt ggactcaact gaatgtggac 1080 acaaacaatg gtcaccaagt cccggaacag gttgtgtgag cctcttcagg ggttcatcca 1140 gcgctgtttt ggagaaatct ctatttcaat ttattcctat acgttagtta ctgaaaaaca 1200 acagacaatc gcaaaagcaa gttgcccgtt ttgtgttcct tgagcccaat catgaagtgc 1260 cgtcgtgact gggcctcatg acaaacaact tgtaacaagt aacaacagag ctcaggtccc 1320 agaccgcact gaagctctgt gagacctctc ctcatctgtg catgaacgag tgtctgactc 1380 tggagcccag cctgctgctt cccagtctgg tggtgaatcc tccgtagtct gatggaggtt 1440 tgctcttgtt gcccaggctg gagtgcaatg gcacaatctc ggctcactgc agcccctgcc 1500 tcccaggctc aagcaattct tacgcctcag cctcctgagt agatggaact acagggcatg 1560 gactggaact cccaataccc ctgacatggg ctgagtcaac gtggtcatga acatgtgaca 1620 ggaggcagca gaagttgcag agaagagtga ggcacgtttg aaaaaggctg aaaaatgttt 1680 ctgtccaggc aagggtgtgt gctgaatgac tcaaggattt tttggagaga attggagtgt 1740 ctcaccagag gagaccacgt ctgaagggct ttgcatccct ccttggacat gtctaatacc 1800 taacactcag aaagcatcca gtaaatattc gtggaaagaa aggagtggag aaggggagaa 1860 aggggaaagg gagtaggcga gagagaagaa agactctgct tcttgcccag ggcctggcat 1920 ggggcggagg caaagcagtg gggtcctcag ctatgtccca ctgtgagtgc acagcgagtc 1980 ctgaccttca gagggtgcag cccgaggggc cctggcctgt ctgaagggtg cgccagccga 2040 gtggcctgct ctgaccacca ggctcaccca tgactacctg ggtggctaca gccagttcct 2100 gacaatgagt acagcactca gttatcgggg cccttccacc cacacgctgt ccacttcctg 2160 gggtactgct gtgggcatgt gagtgcttgc tccccggggc actgctgtgg gcatgcgagt 2220 gcttgctccc cggggcactg ctgtccactt cctggggtac tgctgtgggc atgcgagtgc 2280 ttgctccccg gggcactgct gtggacatgt gatagcttgc tccccagctc cactagtgac 2340 actggcggcc cctcgctggg gccttccccg cctgctccgc tccattaccg ctgccgggct 2400 cctcacgtct ctccttgctg cttcctgcac tggggtgagg agagtggggc tggtcccctt 2460 gagaccggag aagctccagg cttttaagga aaactgccag ggacgaagag aagatatcac 2520 ttccccacgt ggttggcttc cagattcaga aggaatgtct gtccttgtgg attccgtacc 2580 agatgacccc agatgctgcc tcagtactag gtccctgtgg ctctggagcc tttgctgggt 2640 ctgggcagtg tctcttcctc tccagttcat ccttgggtct cttcaccctt gccaggggca 2700 ggcttcctgg tgagaggtcg acctcctgca tgaaggctct caagaggcca gttcaaagcc 2760 aagctccggg tctgtgcctg tggggctgct cctcgatcag gagatggtca ctcccctcct 2820 ggtctgtatc tgtgggattc tcctccatca ggagatggtc tctcccctcc tggtctatac 2880 ccgtgggatt ctcctccatc aggagatggt cactccccat cctggtctat acccgtggga 2940 ttctcctcca ttagatggtc actcccctcc tggtctattc ccgtggggct gctcctccat 3000 caggaggtgg tcactccccc tcctggtcta tacccgtggg gctgctcctc catcaggaga 3060 tagtcactcc ccctcctggt ctatacccgt gggattctcc tccatctgga gatggtcact 3120 cccctcctgg tctataccca tgggattctc ctccatctgg agatggtcac tcccctcctg 3180 gtctataccc atgggattct cctccatctg gagatagtca ctcccctcct ggtctatacc 3240 cgtggggttc tcctcaatca ggaggtggtc actcccctcc tggtctatac ccgtgggatt 3300 ctcctccatc aggagatggt cactctccct cctggtctat acccgtgggg ctgctcctcc 3360 atcaggagat ggtcactccc ctcctggtct atacctgtgg gattctcctc cctcagaaga 3420 tggtcactcc ccctcctggt ctatacccat gggattctcc tccctcagaa gatggtcact 3480 ccccctcctg gtctataccc gtggggctgc tcctccatca ggagatggtc actctccctc 3540 tcggttgctc agtccaaaaa caacctctct ggaaaactgc gtggaatttt tttttaaaga 3600 attgaaacta gaactagcat ttgatccagc catctgccta ctgggaatac acccaaagaa 3660 aaataaatca ttatatcag 3679 <210> 29 <211> 4435 <212> DNA <213> Homo sapiens <400> 29 caaatgcctg gcagcgtcct cggtgcttca cctgccatag ccgacagtgg ctgacctccc 60 atgcctgttg ccttttcttt ctgttggatc agggatacac tgccatgtgt gttaagaaaa 120 gctggcctta cctacagggc tggccagtcc cggtcacgtt tctagtaagc cattgcctta 180 cataagggta acggcatggg acgctatctt agccaatgtg ataaaagtgg acatgaggtg 240 agaggcttca gagagaggtt ttaaaaaaga gacaaaagca ggacgttgcc tctcttcctc 300 ctctccacgt gtcctacccg gatgtgaagc caaaacagat gcaggcttag tgcaaccatg 360 gggaacccag cataagcaca gattcaacag cagaagagtg gcagagggag aaggtgaaag 420 gaacctaggt tttcctgtcc ttgttgagtc attcagttaa aaatccctgg aattttcctc 480 tctccggcag tgtgttttgt gggataatga gttgccttat tggggttggc ttgctagtcg 540 ggatgtttcg ctcccatcaa catccatacg cttgctctgt gaaccaatga cctgatgagg 600 tagtattagc accaccatca ttatgctgag gatgagattt atggcacagt ggttcagtag 660 cttgcccaag gccatgcggc tggtaggttc tggaggaggg ctcagggcac cccctgagct 720 acccctgctg gccattgcac caccccataa agctgctggc agtcacttct ctgaggggtt 780 agcatgtaag aaatgtcctc ctgaatgctg gccagacaaa tggaaatctg ccagggttgg 840 gtacccccat gacagcagcc agcctgccct cttagtccct gacagctgca gtgacagcat 900 ctgtgattgc aaagcgtgac aatttatatc tctcatttca tcacaccatc tatcagcaga 960 cagtcaggct ttaaaaatca atcccacact gactcagtcc ccagcagaga tggcctctga 1020 caacagtatc cacactgcag gctggacaag ggccctatta attttgagac tcagccaaat 1080 ttccttctga ccctaagctg gtgaatccct gctcctttgc tttggttggg gttggtgtga 1140 gctaaggctg tgatcccatt tgctcctatg gcctccaggt ggcctgggcc tccatgaatg 1200 ggccacatgg tcatactgaa tgcttgatta cactcagacc tagcagtcgt ctgggcgcag 1260 ctggtttatg gatcactttg tcacaatgtt ccatccttcc aggtccccat ccccgcggtg 1320 ggaaaacatt gctttaggca gtgctagagg acttcagcag gcattggcag cttctggatt 1380 caggattaga acaaagaagg aggagtcaca gcaaagatag gaacagaagg cagagagaac 1440 agacagatgg gggtgtttga gaaggagggc ctttgagacc tcagggagtg ggagacactg 1500 gctcgagaat aataataatg gcaatttctc tcatctgtgt tttcagggca tggactggaa 1560 ctcccaatac ccctgacatg ggctgagtca acgtggtcat gaacatgtga caggaggcag 1620 cagaagttgc agagaagagt gaggcacgtt tgaaaaaggc tgaaaaatgt ttctgtccag 1680 gcaagggtgt gtgctgaatg actcaaggat tttttggtgc attgaatgaa cagcgggaca 1740 ttggacacct gctgatccat caccccgggc ccgggcaggc ccgtggatga agagagatgg 1800 agaagaccag gcatgagact gtggagaagc cacaccacca gaaacccctg ccccatgcgc 1860 cgtccagccc acacctgtgg atgcacgggg gattgcaggc agggctccca ccgtggactc 1920 aggaacaggc agggaagctg ctgcctcacc aggcgaaggg gccaggaggg ggaggcggag 1980 aggcccgtct agcccctgcg gctgtcaccg tggtgcctcc tcactggcca gtgcggtcgc 2040 gcctcagctt cgttaatagg ggagggggcc taagagtttt cacgtccagg ctcgggcagt 2100 ggggaggcag gcaggagtgg ccgctggttt ttcagacctc ccagggaggc cgaggaaatg 2160 gcccgtcctg gagtgggcgt ggttctgtct tcagatggat gctggagggt tgggctgcgt 2220 gggaccctgg gccctgctgc ttcccggagg atgcgctgtc cggggctgca caggttggct 2280 gtgttttttg gatgcttgat attttgtttt ttcttctctt cactctgtca tgaaactggc 2340 aatagtagtt tgtaaataaa tatgtgttat agatgaatat ttgctatgag taaattaata 2400 aaggagtgaa taaatgagcg attgatgtag ggcctgtcct gtctcaggga gccccacgaa 2460 ggcctgcgcg ccggccagag cctgcctgcc tgccagggta ctgggacgtc actctcaaag 2520 cggcgggacc cagccgctga tcttgctgag gaggcccggt ctcagaaaac tgagcggctg 2580 cttctgcaga ccctgcatcc tcccctccct ggagaaagaa gctctggctg agtcctggga 2640 ccgaaccctt gggtgccaca gaaacgggct ttgctgcctg tcagtcaagc ggcgggagaa 2700 acagacctgg ggaggaggag gctgggaggg ctgtgttttc tgcacagcga gtagctcctt 2760 agcctggtgc catttctctc caaacaccct gaaggttgag tccagggtga agatgtagag 2820 gcaagttttg gggggatgga gtgggcttgg agggatgctg gcgccttagc aggctgtgct 2880 cctgaggtgc ccagtgtctg cgggcacagg aacatgttgc cgagggcatt tgggtgtggg 2940 tggggtgggg aaagggagac agggctgtct cttttaatgg gtatctgcga gcatgtgatt 3000 gtaagagagg aagaagtagg ggaggaagaa ggcctccttg ggaggtgcgt catcctgagg 3060 aaggctgaac aatgagggtc ttggagagtc aattcagaag cacaaccttg cagagcaggc 3120 aaaaacaata gggcttcttg aggctgcccg ggcactcatg caatcaccat ttcctgctgt 3180 gaatgagcct acattttgtt ggggaagaga cgcaacgacg ccaaacgatg gactctgagt 3240 caacgataag atgaaacaaa attaaaacaa agtaggaaat caagagtggc tgctgtgatg 3300 gcgttgcgga gatgatgttt gctttgagaa ctggacaagt gagcccctga gctgcatctg 3360 cacccagagg ctgagccggt gcacaggact tgcagaggga tgggcctggg cttgtagagc 3420 agcacaacgg ccccaggcct ggaggagcaa gggtgggaag gggggcaggc cagctcctgc 3480 caggctggag aaggactcgg acctcaggcc acctgtgcct gggtgattgt gaacttgtaa 3540 caaatgtgat cttatttatg ttttgaaaaa ggcaacacaa accaacacga gccgtgtgag 3600 gatcaggtga cagctgccca aaagctgaca caaggaacaa gcctggagga gtgaggatgg 3660 gtgctgtgaa ggaggttgtg cagctgggcc cgcagtcgga cctggtgaga tcagaggagg 3720 gggtgccacc agtctgtgga cgaagatgag aagctggaat agagcagaaa acaggaggct 3780 gccactctcc atctttccca aagtcactcc aggagcaagg gtgtcattta ctgaaatgac 3840 agactctcca tttcacattt ttcccccaag tgcagagtgc agggaagcag atgggctaaa 3900 tttttagagt cagggttatt aatgtatact ttacatagta aactttcccc ttttaagtgt 3960 gcaggcctga ggtttgccaa atatgtgtag gcatttaatc accaccacga tcaagatgta 4020 gaatattccc actatcaaaa agtttgctgt gtcccttgat ggtcatgccc cattccacag 4080 ccccagcccc agcccctgga gattgctgtc tgctttatgt tccagtggtt ttatcttttc 4140 cagactgtat ggatgtgaat ggaatcagat gtgattccaa ggtgttttat cttttccaga 4200 tgtgaatgga atcagatgta cgaaatccta tggtaggggg tcttctgagt ctagctcctt 4260 ttgtttagcg tgatgcattt gaaattaatc catgtctcag gcatcaggag ttcatttctt 4320 tttctgctga gtagtatttc attgtatgga tgtactgcaa tttgcctatc cattcacctg 4380 ttgatgtaca tttgagattt ttggcaatta tgaataaagc tgctataaac agaca 4435 <210> 30 <211> 4996 <212> DNA <213> Homo sapiens <400> 30 aagatgggac aatttttttt cctcttggtt tctttataat tattgtaccc cttttctgga 60 ataatctttt catcttgttc atctgtcaat gcctgcttgt cttctcagat ttcaactcag 120 gtatattatc ttctcctgag ttattttttt aactgctgta aaggcgtatt tctgtgcccc 180 atatctacgc ttcctaggat aaagcacgtt cctctaatag tgtacaacat ttggcaattg 240 cctgtttgtc tcttctctct gctagacgtt gtgctacttg agaatatagc tttccctttt 300 attaatttat ttcgtttaca tccttctgtc acaggattct accagcctgg atcctatgcc 360 tgccaagggc aagtggagct ggaagggatg tgtgagcaag caagcatcag gtccggccac 420 tgcacatagc tgctggctgc agtggggtgg gcagctccag tctccagcac aagagccagc 480 tccttgcgag gctacagctg gaccagacat cccacaagca gcttccacag atggcactag 540 ggaatgcagt ggcacccaga agcttgaagg caccaggaac cacagagccc caaagagggt 600 gtcacagtcc tggcttgggg aactcctaga tctgggctcc ctgaaggact gcagctcttc 660 tctccttctt gtcacccaca acatggtgag caaggggtgt gtttcagccc tgtttgtgtt 720 acaaagggca tgttcagccc tgccatttgg tgggtcctga gttcttgtcc agtgcccagg 780 aaaaatgagg aatgctgaca agtggagggt tagcaaggcg aagaggagct ttattgagca 840 atagaacagc tcagaggaga cttgaagtgg gtagcatttg tccacagcca gggtgtcccg 900 atgagtgttc agctctcagc agagaggaga ccctggagtg ggcagctcct cttcacagct 960 ggtagtgtcg atgtttgctc agctctcaac agagagggga acctggtgtg ggtagctcct 1020 ctccacagct ggttgtctta ttgtctcctc agctctcagc agagaggaga ccctgggttg 1080 ggtaggttct ctctgcaact ggccatcctg ctgtcttcct aagtctgtct gagtccagga 1140 cctttatggg cctcagaggg gagaaagcgt gcaccgattg attcatgggc agctatgggc 1200 aggcatggaa aaagcaccac aagttcccgc tacagtctgc aggactagca gcctggcccc 1260 caggcttcag gccctccctg gcttgaagat ggagcttcag tggggatctg cccgcttctg 1320 cccaggagcc tgtctgcctc ctgctgccat tcatggcact caggctgttc atgccaaggg 1380 gttcctgaag gtcagcaatg acccgccctc agccctgccc ttggccttcc tcttgtgcta 1440 gttgtgccca aagtccggag gggatgaagg tggcacgggg ttggtgtgtc aatacttccc 1500 tgattgtgcg cacacctggc caggctggga tagtgaccag actcggcccc aaccttgctc 1560 tgagatcaaa gcagatgcta ggagtggaga gaagccaaac agtgggagca ggcacttcca 1620 agcctgtggg ggtatggggg tccttcccag gcccctgaga gtgcagagat gcctgggtcc 1680 acagccgtga catgaggagt tgcagctgtg cctgggaagg tggggctcct cctgcctgtt 1740 cctggctctc accagctccc tggagcgtgc agtgctgcct gtgcctccac actgcagctg 1800 gcatcgtggc agctgccgct ctatacaggc tgccactgcc atcacttcca gaatattacg 1860 ttgctgctac ctagtagatg ttcagtaagc ttcttaattt taataagcat ttaactagga 1920 acatgaagtt ctttatactt tgagacatta tatacctgct tgttattgcc atgagtgctt 1980 tctgtctctt gactgaaaca tggctcccaa gcctgaaaca tcagggataa agtctggtga 2040 ggaaaacaaa agcagagaag agaaccaaga gccagcatgg ttcaccaagg tcacagggct 2100 cttggttact gactgaatcc agactgtagt ccaatgctac tagcaacaaa tctgttcttt 2160 acactgagtc tcggctactt tgcttctctt taaatgcaag taatcaaact ttttcttcct 2220 actactaaac attttagcac aggtattatt tatatactta ttgaatgcac agcttttcag 2280 taacaatcct agatagctag tgtcactatt taacacctta aatctctaat tatgatgagt 2340 ccattttgac ctttcctaga gttcctcaga ggcatcccta ttattgtctt atcattaaga 2400 tttattagta tcatttcatt tacgaactgc cattttcatt ttattttggg gcatatgttc 2460 aaactggcat cttccccagc tgcaatcaat gtacataatg ccacagctcc ttgattggtt 2520 taagaacatt ttcttctcta cggataggaa cacagtttaa ggtttctgat gatggcacat 2580 ttcaagtgat gctgcttaat tcacctgcag ttctcagtgt cttggttgtc tcatattcat 2640 ctttaaaaat aaacttcctg atgttgcaaa ctaagaagtg gtcctaaaga aaagaagatt 2700 aaaaccacag atggtgcaat atagatacca gacatcctat tacactaact ctgagtatta 2760 caattaatgt aatgaagaaa aacttaaatg tgttggcctt aagaagttag ataagaccca 2820 gtaggtgaca aagttgctta cggtgatggt tgatttccta ttccaggttg ttggtttttc 2880 ttttttactg ttctgaacta gaaaaaaaat gtcttggaag ttcatataaa taactttcat 2940 gatttctaag aacaatcatt ggttacagat gaatgttttc aggataattg tcatatagat 3000 ttggttatga gaaattaata aaaattgttc caaataaatt taatgtaata tacatcattt 3060 atatgaagtc tttatcaact tctaaaatat tgcttttaag tgtttttatt tatattaaaa 3120 tatatagtct atcttcactg gaaatatttt cctaattttg ttttcatata attgctttta 3180 ttattgtaat ttctgttgaa catttattta gtactcattg atcaagtcca tacaacaaag 3240 aaaagtttct ctaaatctcc aatgaatttg gctgtgctct gattattcct gcttccctag 3300 ctttcaagac aaacaaaact gtctaaaagt tttaattgta gttgataaat tctgaaaatg 3360 gagtaacttt taaaggctct ttcacacaaa aatcctaaag aaaactcata aataattact 3420 ctcagtaaac cccctcaaat ttttagagct tttttcactt tattcccttg atataaagtg 3480 ttagttttta ggtggattaa aacaacctat tagaaaatct tgccaggtgt gttggcttac 3540 ccctgtaatc ccagcacttt gggaggctga ggcgagcaga tcacctgaag taaggagttc 3600 gagaccagct tggccaacat agtgaaaccc tgtctctact aaaaatacaa aaactagcca 3660 gacatggtag taggtgcctg taatgccagc tacttaggag gttgaggcaa gagaattgct 3720 tgaacctgag aggcgggggt tgcagtgagc caagatggtg gcactacact ccagcctgga 3780 tgacagagca agactctcaa aaaaaaaaaa aaaaaaaaga aaagaaaaga aaatataata 3840 gactgactct acatttattt gtactgttct atttaaaaat attttaaata atttttaaca 3900 gactttgcac cacagaatgt ccaggatata tcaggaagga gcaatgaggt aagtgttcct 3960 caaagtgaca gttataagtg actaagacat agggagatga atcacttggt catcatattg 4020 atctgaattc tgggaggaca tagatcataa atttgaagga gaaaggcaat gcatttctgc 4080 aaatggatac tgcttaaagt ccctaacatg ctccttgaaa taaatggggc acaaaagagg 4140 ttgttttacc ctaaagcaat tttacctcca atcttggcag atttccaaat ttttgagact 4200 tgaccatagt cttatgttag agtggcttta aggggacagg caatgggata ttcactggat 4260 gtaaaatcag atgattttgg tttgaaagca agccttttca cttatcaact tcttgacttt 4320 cagcaaatca tataacatct caaattatta attgtcatat tatctgtgaa tgacatatat 4380 atacatatat aagccaagag tgttttgtaa gcagtgaatt tctttactgc catattcaat 4440 aaagcaagca gttgttaggt gatagtcatt catttattca ttcaaccaca ctgttatgtt 4500 gggtggagga tactgacatc catgaaaaac aatcccctaa tttcaagaca tgtatagtcc 4560 agaaagggtt gtagactcaa ctcattgtgg ctcacagatg tattttgtct gctggcatat 4620 ttatttaaag ttggaattgt aaggcctttt aataccctct ccagttagtc acatgctcaa 4680 cctctccttt tcttatatta acctgcttta gtcaaacaag gtcacacact ataggtactc 4740 tctttagtca aattattttt tccagtggat atgccttatt tatgttgcag tttgacacta 4800 aagctacatt caagaaaatg tttctccatg caagctgttg gaataacatc cataagaatt 4860 cagccattct tatttgtata tttgtccaaa atgctccttt tcccccattt tacttctaga 4920 ttatgtatat ctgtaaatgt ttcttagatt tactttgcta cattatagtt ttgccaaaac 4980 atacccctgc caaaca 4996 <210> 31 <211> 3938 <212> DNA <213> Homo sapiens <400> 31 agctgctggc ccccctgggt ccagaggagc cttgccgccc tcacctgcgc agagcctgga 60 gccgacgcgt cacccccagc ggaagcgcct cgctgcccgg gcgtctggcg aggtgtgcgc 120 tccgggtccc agctccagcg cttcgcggca gtcgcccgcc tctttccgca agcagggcgg 180 ggactgggcg gcatctaccg agatctgcga ttcgaggcgc cgaggagccg aagaccacag 240 ctcagctcag acggcgccct agggccgcac agagggtcgg gcagtgccgg agagaggttt 300 gaaagcgccg ccgccaactc gacagcgcgt cccagcgcct tgagctcgct tcctcctgct 360 ctcaggaaaa actgaggaaa cgcgcctggt tccaggggtc ggcggggacc gtggagacgc 420 tgccagcatc ctcaacagct tggaaatccc atcaccttgg ttccctgaga cttggaggac 480 tagtaggaac tgacagctgg ctgacagaaa acttatccag ggagagaaga gacaaaagtg 540 aagtgtgaaa ttttgaataa tgttttcaga tgctttgcat tcagaataga cctctgagtt 600 gggacccaag ctgtcaactg atcccaaatt cctaagttcc tgacttgcag gtattgagtt 660 ctaacctccg aagatggatg aaggtatgga aatttcaagt gaaggaaatt ccttgatcaa 720 agcagtccat cagagccggc ttcgcctcac aagacttttg ctagaaggcg gtgcctacat 780 taatgagagc aacgaccgtg gggaaacccc tttaatgatc gcttgtaaga ccaaacatgt 840 cgatcaccag agtgtcagta aagccaaaat ggtgaaatac ctgttagaga acaatgccga 900 tcccaacata caggacaaat ctgggaaaac ggctctgatg catgcttgct tagaaaaagc 960 tggccctgaa gttgtttcct tgctcctcaa gagtggggct gacctcagct tgcaagacca 1020 ttctagttac tcagctcttg tttatgctat aaattcagaa gatacagaga ccctgaaagt 1080 tcttcttagt gcttgcaagg caaaagggaa agaggtcatc atcatcacaa cagcaaagtt 1140 gccctgtggg aagcatacta ctaaacaata cttaaatatg cctcctgtgg atatagatgg 1200 gtgtcattcc ccagctacct gcaccactcc ttcagaaata gacatcaaaa ctgcctcatc 1260 gccactttca cattcttctg aaacggaact gacgcttttt ggctttaaag atcttgagct 1320 tgctggaagc aatgatgata cctgggaccc aggttcccct gtgaggaaac ctgcattggc 1380 ccctaagggg cccaagctcc cccacgctcc accctgggtc aagagtcccc cattattaat 1440 gcaccagaac agagtggctt cattgcaaga ggagctccag gatattacac cagaggaaga 1500 actatcctat aaaaccaatg ggctggcact ttccaagcgg ttcatcacta ggcaccaaag 1560 cattgatgta aaagacactg cacatttgct aagagccttt gatcaggcca gctcaaggaa 1620 gatgtcatat gatgaaataa attgtcaatc ttatctttca gaaggaaatc agcaatgcat 1680 tgaagtccct gttgaccagg acccagattc taaccagaca atatttgctt ccaccttaag 1740 aagtatagtt caaaaaagaa acttgggggc aaatcactac agctctgatt cccagctctc 1800 agctggcctt acccctccaa cttcagaaga cggcaaagca cttataggaa agaaaaagat 1860 cctctcacca tctccttccc aattgtcaga gtccaaagaa ttgttggaga atatcccccc 1920 aggtcccctg agcaggagaa atcatgcagt tttagaaagg cgaggttcag gagctttccc 1980 tttagatcac agtgttaccc aaaccagaca agggtttctc ccacccttaa atgtaaattc 2040 tcaccctccc atctcagata tcaatgtcaa caacaagatt tgcagccttc tttcttgtgg 2100 tcaaaaagtg cttatgccaa cagttccgat tttccctaaa gaattcaaaa gtaagaaaat 2160 gttgttaagg agacaatcat tgcaaactga acaaattaag caattagtaa acttctagga 2220 gatgggtata aaacacatct tcttcaaatg tttatatcag agaaacaaag aactagagaa 2280 gaaatcttaa atgttcattc ttttaaatct cgtgattggt tagtccataa tggctagatg 2340 gattaaaatg taatgtgatt tgtactaggc gtcatgagca taaaaaataa tacatagttt 2400 ctgttaaggg aattctctca aacaaaagga aagcgatttt tctcaatgct tctaatattt 2460 aacaatctcc atgtagtcca aatttgtcat taaaaaaaaa tcaaagaaag aaggccacgt 2520 atgttggggt aatttttaaa aattttcaga ttggctaaat attttattag gaaacagttt 2580 tcaagtcaat aattttttta acatttcatg ttaataaatg agattgaaat tttttatgat 2640 ctctaaacca taaaagaaaa caccgacagc tgtaaaatgt tctaagataa aaaaactcga 2700 gctacaaaga aagaatgaac taattcttta caaatgttga ctgaagatag ataaaactct 2760 aattaaaaat ttaaaaggtt aaacactgta ttagaatggg caactaaaat attcgtggtg 2820 tcagtttaat tagtgtcaaa ctggcaagtc agagttttac aacctactag taatctatgc 2880 cgggtcttgt tgtttgtgca ctgtgttttg ctttgctttg ttttggtttt taaacagact 2940 tacctgtaaa gttatcttac ggaattattc tttctccata tcttttaagg aattattctt 3000 tctccatatc atcttttaat tcctgttatt agttttggaa gcttatccat aagtttccaa 3060 agacaagatg atataaaagt taaaaagcat tcctctttac ttatatcaaa ttattcttgt 3120 ctttcaaaaa gaaccaaaaa aaaaaaattc atcatggata aaaactaagc gcttgccttc 3180 ttttaaaaag aaaaactgat gattagatta ggttagctaa aattaataga ggcagtagaa 3240 acttaatcac aaaatgtact aaatatttgg caatattaaa caatgccttt ttatttctga 3300 tatgtagtta ttagacattt atatattaag gataacttcc ttagtgtgac attccaatca 3360 tttagtattt taggacctgt gaataacttc caacaaaatt aatgaatacc atattagtat 3420 tataaaatat tataaagtaa taattatatc atctatataa cttcaaagta tgatgtttat 3480 acaaagaatc cttatttcag tctagcagct taacaacaaa ggataaatca gactatacaa 3540 aacctaagtg tattaatttg atgattgtca cgtacaactt tctttgcctt ccaagtagag 3600 gtgatcctaa caattggcat gatgcttttc ttggtaattt gatataagca agttgtaatg 3660 tacatagtaa ttatttaatt actgtggctt ttattttaaa aagtaattag aggtttttcc 3720 atttcatgtc ttgaacaaca ttaatattaa ttacactaga aatatttttt gattcagaac 3780 ttagaattgt acctgatatt tataggtatt taaatgcttt ctgcaagtta aatatcgaga 3840 aaagtacttg acttcaagtt gtaaggatac aatttggaag ggtatgtaaa tagattagtt 3900 cataaacaaa atggtatcaa taaagatttt aaatatca 3938 <210> 32 <211> 542 <212> DNA <213> Homo sapiens <400> 32 agctcagctc agacggcgcc ctagggccgc acagagggtc gggcagtgcc ggagagaggt 60 ttgaaagcgc cgccgccaac tcgacagcgc gtcccaggaa aaactgagga aacgcgcctg 120 gttccagggg tcggcgggga ccgtggagac gctgccagca tcctcaacag cttggaaatc 180 ccatcacctt ggttccctga gacttggagg actagtagga actgacagct ggctgacaga 240 aaacttatcc agggagagaa gagacaaaag tgaagtgtga aattttgaat aatgttttca 300 ggcacggccg tcgccagcat agtaccggct cctcttcttc tcccagaacc tcctgacacc 360 aaccttggtg aaagaaaagc tgtgacaatg ctttgcattc agaatagacc tctgagttgg 420 gacccaagct gtcaactgat cccaaattcc taagttcctg acttgcaggt attgagttct 480 aacctccgaa gatggatgaa ggtatggaaa tttcaagtga aggaaattcc ttgatcaaag 540 ca 542 <210> 33 <211> 12351 <212> DNA <213> Homo sapiens <400> 33 aaacaggaaa agaaattggg atttttatga aaaatgttaa aggctagctc tgttaggatt 60 tcccatgaca ttgcagtggt gacatggtcg tggatgtgcc aaggaaagcc tgagctgttg 120 actgctgccc cagtagcatc agagaaccac tgtgcttgct gagaccaatg actgccattc 180 tggacagggc agcctttggc aacattcaga agcaagctgt ttgtcttcag tcccctctct 240 tcagcctcca aatttgtcat tattgcttgg tggatggagt accctatact accccatggc 300 tctccaaaac ccttttcctc ccagccagga ggcccaggtc tgcgcattca ctcactcgat 360 tctgtgcatg ttgcctgtgt gcggtccatt gccctcacct cactttcctg gggaaagaaa 420 aaatgacact gagctgagga atgagcaaaa atctaggtag agacgtggga gaggctgtgc 480 tagttggagg gcgtgaacaa aatcgtggaa gtttacaact gtctgacttt tctagggaaa 540 ggcaagtaat ctgatgtgac tagagaaagg ttaggtgaga tctgtaagct ggtttgggtg 600 tagaaggaca aagaattgga gtgggaaggg taagtggcag ctagactggg aagggctgag 660 caccaggtaa aaaagacaaa ataaaattgt ttctcctctc ccaggaaata ctgaacttta 720 ggaggcaaca tctccatcct ggctctgtaa accaatcttt atcagaatga gaattttggg 780 gtaagttgga agggacaggg ccaggcttac agcagcggtt ggcaaactat ggtctgtgag 840 ccaaatccaa ctgctgcctg tttttgtgtg gcctgtgact aagaatgatg cttacatttt 900 taaatggttg agtaaaagtg aaaagaaaaa taatattttg tgacttgcaa aactgtacaa 960 aatccaaatt tcactattca cacataagtt ttcttggagc acagccacat acacttgtga 1020 tgatttcact gctttggtca tacaagggta gaactagaac tgaattgttg tgacagagat 1080 cctctgtccc gaaagggcct aaagcatttc ctgtctggct ctgcttagaa aaatattgcc 1140 aagttctgtg ctgggcacgg tggctcacgc ctgtaatccc agcactttgg gaggctgaga 1200 tgggcacatc acctgaggcc aggagttcga gaccagcctg gccaacatgg tgaaacccca 1260 tctttactaa aaaaatacaa aaattagctg ggcatgatag cgggcacctg taatcccagc 1320 tacttgggag gctgaggcag gaggatcact tgaacccggg aggcagaggt tgaagtgagc 1380 cgagattgtg ccactgcact ccagcctggg caacagagca agactctgtc tcaaaaacaa 1440 aaaacaaaac aaacaaaaca aaacaaaaca aaaaacaaag gagtcgagca ctagacagaa 1500 agttcagagc aggatggagc tctacaaaga taacctaagt tttatggagc tgagttccca 1560 aatcacttta actaaatgta ttaattccag tggccatgat ttccctagca cttattctcc 1620 tgtagcataa ttggaaattc taacaagcct ttttttgcgg ggagggggga gggtggaggt 1680 tgtttgtttt tagtgtgaga tgtggattaa gcatattaaa aattttaaaa taatttctgg 1740 gaaatttgga aaactgtgtt gacagggtgg ttgccatgca ttttaaggaa cattcacatg 1800 gttgaagagt catagagaaa acattgtctt tcagaatcac tcatccaaat caatataaat 1860 aaattgctaa gaccttttct aaccttttaa acattcatct ttcttcatga gaacagcaat 1920 aaatgtcctt tgtttctgga gtctgccaat cacctatttc ttctttagtg tgggtaattt 1980 aaaaaattgt tttcataagg ctaaaagaca ttatgttata caatgtctct attttttttt 2040 ttaatggcaa ggcagacttc attcaagggt ggcacattgt ggtaggtata ggaaccattg 2100 caatgagtgt tgcagcaggg gagggagatt ggagtcaact cactactgtg tctttacaat 2160 tttatttttt ctttcagaga cagggacttg ctctgttgcc taggctggag tacagtggcg 2220 taatcatggt tcattgcagc ctcgaaatcc tgggctcaag caattctctg acctcagcct 2280 cccaaggagc taagaatatc tttaagtttt tttaaaaagc aatccttact tcctgaatgc 2340 accaaaattg taatcccatt ttgacccagt taagaggaaa actcaaaact gagagggcct 2400 ggttaaagaa aagtgagtag aggatataat acaatgattg acaggaaacc ctggtgtgtt 2460 gtgagacaca gcagtggagt tgttaagagt cgcctcccag ttgatgtatg ctatctcaga 2520 atatccagat ttcccagctg acatcttctg cctcccctgg ggtggtgtgc aaatggagac 2580 tgtatcagtc agggttcagt tgcagcaaag ggaagcaact ctagttattt taagcagaaa 2640 tgtttaatac aaagaattag ctgcatggaa gtgctggtgg aagagatggt ttttgggaga 2700 ctcccaggac acttgagagc ttaccaccta ggggaacaac tacctcttcc atgaaggtgg 2760 ggagtcagaa agttgctata ggatcaggaa tctgccattt tttcctcaca gatgcatctt 2820 gactcccatg aagctgggaa ttacaagtac cctgctggaa tgctgctgca gaaatatatc 2880 tgcactacca tattttctag tgaaattcag ccaaaagcag caggaaaatt atctctgcct 2940 cacttccact ttccaaacct tgcacaagtg catccaagtg gggataagta ggtgatcaga 3000 accctagctg caagagattc caggaaatgt agttttttta tttctagact ctctatgtgg 3060 ggagacacac tggaagggag tgaaagagaa tgttgaggtt aatcacctgt atttgcttcc 3120 tattgctgct ggaataaatt ggaacaaact cagtggctta aaacaataca catttgttat 3180 ctttcatttc tggaggtcag aagtctgatg gaggttttac aaggctaaaa tcaaagtgtc 3240 agccaaggtg tgctcctttt ggaggctcta ggggagaatc catccatccc ctgcctttcc 3300 cagcattaga agactttccc acattccttg ctcatggcca cattgctctg acttccgctt 3360 ctgtcatcac atcaccttct atgactctaa ccttcacatc tccgtcttat aaggactctt 3420 gtgattacac tgggttcatc tgataataca ggataatctc acctctcatg attcttgact 3480 taatcacatc tgcgattccc atcttccatg caagaaacac attcacaggg attgatatgt 3540 tgacatcttt tggggggtca ctattcagcc tgccacattg ttcatatcca aattattgag 3600 ggaaggagct gatgtttatt aactacatgc tatgtgctgg aaactttata tatatatata 3660 ttatctcatc aaacattcat gacaatcctt gaaggtggca ctattactcc tactacaaat 3720 gagaaaaaga gattcaaaga attttaaata cgagtccact attcagcgat aaaaaaaatg 3780 aactattaag ccatgaaaag acatacagga accttaaata catattgcta agtgaaagaa 3840 gccagtctga ataggatacg tactgtatga ttctaactat gtgacattct gggaaaggta 3900 aaattataga gtttataaaa atatcagtgg tttccagggg ttaaggtttg gggcagggcg 3960 ttgagggtaa gtaggcagag ctacattacc ctacttatga gcaatgagtt ctccccccaa 4020 aaaatcattt ttctatcaac caggctggag tgcagtggca tgatcttggc tcactgcagc 4080 ctctgcctcc tgggctcaag tgatcctcct gcctctgcct cccaaatagc tgagaccaga 4140 ggcatgtgcc accacatcca gctaattttt tatttttggt agacttggag tcttgttatg 4200 ttgtctaggc tggtctccaa ctcctgggct caagtaatcc accagccttg gcctcccaaa 4260 gtgctgggat tacaggtgta agccactgta tcaggcccaa atttttgata tcataaacaa 4320 cctgtggcaa atattcttgc atatgcatct tttcacactt ctttgactat tttttgctaa 4380 tacattccta agggtaggtt ttctgagtca gatggcaggc acattgtaaa caccttttat 4440 atatatatat ttagaaagtg tcagtggtgt gctggaactc tgaaacaaat tagagctttc 4500 cccctcttct atggagagct gactattaaa catttagcat actactggaa agtgtgtaca 4560 aatctccagt cctaacagta tatgaggacc cattattttc acctcaaaat ccatactgat 4620 gcttaaaaca gtaatatgtg ctagttgtaa tttgtatatt ctaatactga tgattcatag 4680 tacctgttgc tatctctagt ttttcttttc tatagctcat ttagaggtta aaagaaattt 4740 caggtatatt tgggcatatt tcatactcag ccaggtcagt atggtccatt aagggcaagc 4800 aaattttgca gggatttagc ataattatgc aataattcca aggagtctct gcactttgga 4860 aaattgttat ttataaaaac cttttaacta attgttttgg catacattgt tgatctgcag 4920 ggaacttggt gacacacaga gagggaaggg gagagagtga ttagaatctc caggagtcct 4980 ttatctaatt ttccatcatc ataccatata ctccatttaa gcccacgggt ggggatcttc 5040 ctgaccttgt tggtactgct accctggtag ctagtaaacc actcttttaa tgtggttgtg 5100 ttgcttctgt tgcagtggaa taaagatttg gaccactgag tcatctagtt ctaagaagct 5160 gtgattctat cagaaatgat caatgggggg agtcagctgg cataatgaaa atagcatgaa 5220 tttgggggtt aaggtctcca gaattctaag tcctgctttg ccacagggct atgcattttc 5280 tgtcattttc tactccacag cttgattggc ttatctagcc aactagattc ctgcttcatt 5340 ttccctaatc actcctggta gatcttttcg ccaaggattt acaaaggagc tactcaagaa 5400 attcccatgt gaaagagtga tagtcttcta cttgataaaa gcataggaat agcccctttg 5460 cctctagata actgaatgct cttagacaag cctcagtttt cacatgaata gaatgagtac 5520 atgtgtgtta gtctattctg gcattgtaat aaagaactac tgagactggg taattgaaaa 5580 gaggtttaat tggctcacgg ttccacaggt ggtataggaa gcatagctgg agagggctcg 5640 ggtaacttac aatcgtggtg gaaggtgaag ggaaagttgg cacatccttc atggctggac 5700 caggaggatg tgtgtgtggg gtgctacaca cttttagata accagatctc atgagaactc 5760 actcactgtc atgagaacag caaggggaag tgtgccccca agaatcaatc aggccccaac 5820 cctgacgatt acaattcgac atgagatttg ggtggggacg caaatccaaa ccatatcagt 5880 gtgtgtgtgt gcgcgcatgc gcgcgcacgt ttagaggccg gggggaactg cactcaatgt 5940 gtgagtcctg aagttcaatg attctatgaa accaattcac ctgtatagta aatgtggtgg 6000 aatcacacta gtgccttcaa tagaaactaa actcccttaa aagaagcgtt tgagttagct 6060 tccagagact gctatgtgag aacatgatgt taagttgtca tatgtatgct ataatttgat 6120 tctcactgga agaatgcagc agtgatgtaa gaggctgttt gtgaaattag gccatcaggg 6180 aatgcttgtg ccccatgact gtaaggacta taattctctt acacacagac atcaaatgtt 6240 attgcaaagc cattggaaaa attctaatta ttttaaaggc atatataaaa tatgtacctt 6300 ttattaaata atatgaatat aaagtaagat caagttctga ctctgagctg tccatgctga 6360 tgacctacag agcattgcca gctttagtct ctgcattgcc ttcttttctt gtaagtatca 6420 atggcagttg cccactcaat gtaagttgaa gggtgcagct gaaatcacca ccgcatcccc 6480 aaaatatctt ttccaccaat gcttttgaaa ccaaaggttt gccacttgag atgaagaaat 6540 cctttttcta ggtttttacc tctagcaccc ccttgttaag aatattgcaa tgtcaattgg 6600 tcattactaa aggccagaga tagccaatgc aatcaccaag tgtatcagcg tatcaatttt 6660 tttttttttt gagatggagt ctcgctctgt cgctcaggct ggagtgcagt ggcgccatct 6720 cggctcactg aaagctcctc ctcccaggtt cacaccattc tcctgcctca gcctctcaag 6780 tagctgggat tacaggcacc caccaccacg ccagttaatt tttttttgta tttttagtag 6840 agacagggtt tcaccgtgtt agccaggatg gtctcgatct tgtgatctgt ctgcctcggc 6900 ctcccaaagt gctgggatta caggcgtgag ccactgcatc tggccttttt tttttttttt 6960 tgagactgag tctcactctg ttgcccaagc tagagtgcag tggcaggtat gagcttggct 7020 cactgcaagc aacctctgcc tcccagattc aagtgatttt cgtgcctcag cctccctagt 7080 agctgagatt acaggcacca gccacaacac ctaatttttg tagttttagt acagacgggt 7140 tttcaccatg ttgaccaggc tggtcttgaa ctcccgacct caagtgatcc acgcaccttg 7200 gacttccaaa gtgctgggat tacaggtgtg acccactatg gccaactagt tttctgggtc 7260 ttctgtaaaa aaaaattacc atgaacttgg aggcttcaaa caatttaaaa aatgctgtta 7320 tagttttgga ggccagaagt ccaaaactaa ggtgtcaaca gggttggttc cttgtggatg 7380 ctctgagggc aatccattcc ttgcctatct cctagcttcc aatggctgct gccaatcctc 7440 agtgttgctt ggcttgtaga cgtattgatt cagtctctgt ctccatcttc acatctcatt 7500 ttcctctcta tccccgtgtc tccagtttct ttctgccttg ctcttatgac tcctggcatt 7560 agattaaagg tccaccccaa atctaggata aactcatctc gagattttta catctgcaaa 7620 gatgtaaaag aattctttgc gaagaagcaa agaattatat ctgcaaagat ctttttcaaa 7680 ataagtttac attcacaggt tccaaaggtg aggacatgga catatctttt tttttttttt 7740 ttgtcagggt ccaggggcac tgttcaatcc actgtagcat gggaagccct gataaaaaga 7800 gacacaggac aagtaagtac tgaacggaag ggatggtaaa aagagagatt tgaaaggtag 7860 gatgagaaca ctaggctgga attgggggat gggttggaga ttgaaggata aattctttct 7920 ttcttttttt tttttttttt gtttgttttg ttttagtttt ttgaaacagg gtctcactct 7980 ctcacccagg caggagtgca atggcgtgat ctcagctcac tgcaacctct gccttgtaga 8040 ttcaagcaat tctcgtgcct cagcttccca agtagctggg attacaggca tgtgccacca 8100 tgcccagctc atttttttgt atttttagaa gagatggggt ttcaccatct tgaggtcagg 8160 tttcaaactc ctgacctcaa agtgatctgc ctgctttggc ctcccaaagt gctgggacta 8220 taggcatgag ccaccacacc tggcctggag aaattatttc cattttactg atgagcattc 8280 taaaagggaa attgataatc ttgaagaact ttgcctgggg ggttctcctt gcaagggatt 8340 ctttggcctg agaaatcact ggcccttatg ctgttggtgc cataagagaa tctgggaatg 8400 tgactaggac cgaaccattt tgtgcgtgtt tttttggctg tttattcact tgtctattca 8460 tccatccatt cagtaaacat ttattgagca ctttctttgt tcctggaaca tagaaggcta 8520 cctccttctc aggtgccttg ttgggatgtt ctgtccctgt ttgtatccag cgttgggctg 8580 gcagtttagt ggagttgcac atggtcaagt cagccactaa gattacaatc aagtagagtc 8640 aaaattgcct tagaaaactt ctgaaaacat ctataaagta cacctaaatg ggtttctcca 8700 atctgaatac ggggttcaga cacaataaac aatcgcagga tggagataat tgaggaacac 8760 gatgaagcac atcctaggat gataattggt tttgtcttct aacattattt taattcttct 8820 tttcttccct ttgccgcact tacagaatta aagttgtgaa aattatatac gtacttcacg 8880 tgattctagt ctactgccac acaaggctct ggtggagatg tagcaactgg aatctttcaa 8940 aaccgtgtga gccagaggca gccataggga tattatggtt gcttgtttat tcagaagtca 9000 ctgttgtgtg gttgaaagag acatgggcta ctcctctctg cttgaaacag aaaattccgt 9060 gagagactca cgcaacctac aagaggctgg gttgcctcat ggttcatctc aatgatgtcc 9120 tcataaagga aactccagtc aggtagccct caaagcattg aaaacaatgt aatttttcct 9180 gaaatctcat gaagctgcac cgaagaggaa acccatacat agcatatttt cttaaaattc 9240 cgtctcacat ttctttttta atatttcaca catcacagat ggcagttacc taaaattccc 9300 actttttatc ccttaacatt ttgcaaatcc tccccaaatt ttttgcactc tggctcttct 9360 ttctccctgt cctctggttt tcctgatctc aattttatcc ccttttacat gtaaatcagt 9420 ctagatggct gtagtatttt ttcattttct tgaccactgt ttccttctta tgagatccat 9480 aaagcgcaaa gcaaatctac accgaaaact ctggaattaa ccaggatttg aattgagcag 9540 tttgattttg ctacttagta acaatgtgat tttgggtaaa tttcttaaac tctctgattc 9600 tctctctttt tttctaattt gtaaaataaa gccaataata ccaaattggt agagatggtt 9660 tgaggattaa gtgaaacaat atattttcag attcctatca caatgctggc catattaggc 9720 ggtttaaaaa aatgctggtc gttttctttt tcttttcttt gtagaaagat ctccttgtag 9780 agacaaatca caatcaaaga ctttttggtt aatgtggaac gagatcatgt gaattagagc 9840 acatggcgct ctaaaggctc catgctaaga ataactgaca gatccatgct acggcaaaaa 9900 ttgttttgca atgggaacta cggctagggg tctgcctccc atcaaggatt tatttatgga 9960 ggaattccca aaatacagga agaatgttca aatagtagca gccaggaaat ttccaacatc 10020 tgctacactg ggtcactctg aattggtctt tttggcttct ttctgtaatt tccattttgg 10080 gaaatcagga gttgtgactc acagtggtaa atcttcacac agttgaaata tgccttatta 10140 gcacaatcta ttttagtatt attaatgcca tagtataaat atgtacagca ttagaagtag 10200 tcaattagtg gaggctgatt tttattttac ttctatgttg gctttacttt caaaatatat 10260 gttatgttat tattgttttc cttttcttca ttttcattgc tacctttctt ggtccaagcc 10320 atcactatct cttaggtagg tgatgagata gagcactaag aggtctggga ctcttccgcc 10380 cctacacagc agccttgccc tccacatggc agctggagtg atctttataa aaccacacat 10440 gagaacatgt tcctcctctg atggcttcac accacatctg gaataaaacc ctaacatcct 10500 accctgaccg agtgggccct atgagttccc cttgcctctc tgagcacatc tactcccccg 10560 ctcatgctgg gtcggccttc tatccgtacc tttgaccatg tattccctct gctttgatct 10620 cttcccatct attcttacag ggctggcttc ttcttgccat tcaggtctca atatctcctc 10680 agacagactc ctagcccctt aatctaacgt agacctgctt ctactccaat cattatcgtt 10740 ctgctttatc tttgtagtgt gtgctactct ctgacatttt gaattatttg ttttcttgct 10800 tattgtctgt gtaggggaga aaagatttct ttcctcactc attgtaaagt tcatggccaa 10860 caaccctatg acaaaagagt aataagcaaa aagcttgcaa atgcatttca tgtaaatctt 10920 acatgacatg tgagccttca gaagcaaagc cccaaagacc cagggaaaac tgtattttta 10980 tggacagcca tacagaagta taattgaagg acaaaagggt ctgatccaaa ggtaacaaac 11040 tgggagaaat gtagtaagac ctgtttgttc agtttcttct gtgtgggcac ctgccacatg 11100 agtgtcttca ggggagaagg aacagaagag gtcggagagt gacgatcctg ggttttatgg 11160 tctgcttcag gggaggaaag cctgagagaa ggtcagagac gccttcctac ttctgctgtt 11220 ttttcagttt ccaaggtgtc agtcatattt tggggtatca cacctgaagc ctctgcgaga 11280 ccacaggtct gtgtgcctgt ccagtgtctg ggacataaca ggagcttaaa aagcattctc 11340 tccacacggg gatttaccgt agacatgttt gtgaaaacca aacaaatcct taattcctct 11400 ccccctgcaa ggtgtccttc ctccatttag agctgccctt ttccagagtt cccagggtct 11460 ctgggtcatt accaggttcc cttatcacaa agagaaagag tggaagtttc ctatgttttc 11520 tctcctcaac ctccagtcag ttttctccat tccaggctgc ctttgctgtg tgcaaagctc 11580 aattgtctgc ctcaatttta ataattcagt gttgaatggg cacatttgca tatgcaaata 11640 tttgaagaat tgaaatggca attaacagat gtatatttgg gattaattta aaatattttt 11700 tgtcttttcc tgtttacttt catggtccag cagtaattct gatcttagtg acttgctgtg 11760 attcctccat ccaatgtgtt tccaggtcta ctctagccag agtcagattt ctaaaagatg 11820 ctgtgctgtc tttgaatacg attgaaaaat caccatttta acccctttat agaacctaat 11880 aaagcatttc agaagtacct gcatttcttt ttatttctac ctggttgatg agcctctctc 11940 tttcaaggct tcagctagag gagaattgat caacacgtgt tattataatt atttgaggac 12000 ctaccatgga aagggcactg tgctggaagc agctggggga atatagagag gagtaagacc 12060 aaagccctgt cctctggagc cttatggttc cacaggaagg agaagatgtg aagactcgtt 12120 acctgaagtt gacatttggt ggatgacaca gcattcaaca caaaacattt gccatccccc 12180 aaaaagctgc caactgttac tggatggctt tggtgatttc catgacattt ttccaaaata 12240 caatgacttt cctcttgtgg tttttgtaca tcaacaaatc ttttcaacta acaactactg 12300 ggaaaagtga atctatagaa gtttattatt aaataaacta acatgaaaat g 12351 <210> 34 <211> 31532 <212> DNA <213> Homo sapiens <400> 34 tccctccctt ccttccttcc ttccttcctt tcttcccttc agtttctctt ccttctaatg 60 ccccctgtcc ttaaaaatgt ctccattcag gcactatgca atttgttaac tccacttctc 120 aaagataaat ttctggtcag agtgttctat tcttgctgtt ttcattttcc cacctcctat 180 ttactcttga atccacagga atctaggttc tactcccaac aatttgcaaa agcttctttt 240 tctaaaatca caaatggtac tgctcctaat taggaaatcc agtagacagt tttgagttct 300 tatcttattg ttctcttaca cattgtttga acttctgaat tatttcctcc attgtagacc 360 tctctgtttc ttcagagttc aaagcttcac attctcctta cagctcacta cccactctcc 420 ttctgtttcc tacatggcct ctgcctgtgt caaaaatgtg aaagaataga gctgtgctac 480 ttccatagaa acatgaggga gtatattcat aaattctgca agacatgtac gcatacaaaa 540 ttaaacaaca acaagaggaa tgtgctcaag agaacacatg acaggaactg tggttcagaa 600 gaagagcaga tggagagtgt gggtaagagt cgttctgtaa gcatcatgtt gatataggat 660 gagtgtggca ttggggctgc aaatgccact gcagtgggat cccagcactg acagccatag 720 ggccttgggc aagttacttc ggcacaatga acactctatg ggaatagtaa tagttatgtc 780 ctgggactgt tgagaaaatt aaacaaaatc cttaagccat tatttgcagt agtacctagt 840 atgtgcttca tgaatatatg ctcattttca taaagaaagg gagtcttgag aacacttttt 900 tctcctctct cctgcatcca agcctgaaga ggcagaagga actccaggag ttgaatggaa 960 gagcacagaa gggaaacagt gagcatcgtt actactgcac cctcatccca gctatgatct 1020 gctaatcctc agatagcctg agacggggta cggaaagtgt tagatgacca gcaggttaga 1080 caagaccttt gaccaatgtc agaaaggtgc ctggaaaagg tgtgggacct ggctgagatt 1140 tcatctgggt acagagaata atttaaaaag cttgctggaa ggcagtggta tgatgaaacc 1200 atgcaattct tgtttaattt tacctatatc aggtctgtct tgttcaataa atgagttata 1260 tgtacttaca aatcattaac aggtagtact atcaaaccat acttaaaata tttctgagtt 1320 ttcaattatt tccttttcta gataaagaaa tagcgacaga ggcaccccag tggatgtccc 1380 tgcacacctc cactttgggg actattctaa gagcaggagc ccaatggggg ctgcaaatgc 1440 cactggaggg caggtgatcc atgaccagtg aagacagaaa aagaggagaa tgtggtagtg 1500 atggaggttg atattgctgt ggtagaacat gtggaaggaa aatgaagata ggcaaaaatt 1560 gaggctcttc agattcattc catgtagggg aagagggggc aaaagtaaga gcattgttca 1620 agaacaacca ggtagaaaca aaaggaacag agaatgtgtt gacctccaag ggaagaaagg 1680 aaagcaaaga catttgtgtt acagtccaaa gaggacagtc cagagtaaca aggatggagt 1740 atttgagtat ccccaagagg cttacaaaaa ggaactttac ttatagataa gcaatgatag 1800 ggtaaaattg aaaagaacta aagagaaaga aactaagaca gttgacaccc tggagaaaaa 1860 gtttatgagc ccctactaca gtcatgcatt ctcaaaataa ctgctaaaca aattagccat 1920 ctcagtaaag caagactggg taagaattta agaatctctc catcctgggt tggcaagtga 1980 tgggcagaat aattgaccag acatcctcca gctcagttcc tgggatgcag agatgctggt 2040 ggaagcactt tgtagcacag caaggtgaga gtttgaaggg gcttcacttt ctgaaaaatc 2100 tctcttcata atcctgtttt tccatttcag aaagaattta aatcaaaaac cttaatgttc 2160 ttgtcatctc tgaacacatg ctgaatgcag gggaaacacc ctgaagtagg aatttctgat 2220 ctccctcttc ctttgttgtc attcaagaat accaactcag cttttacaat ttgatgtcct 2280 tctaacttga ggaaaccatg ccattacgaa cactcccctt gccttagaag aagatatgtg 2340 agttgggtct tagggagact aaggaaagaa aactctcctt actggggaca aacagtatcc 2400 tagaacactg gattctctat cagtagcttc tgaccccagg ggtgtcacac agagctttgg 2460 acttaggaaa agtcacatag catctttgag catggagtcc caattggtaa ttatgatgta 2520 tgttgctgcc tgatggttca ggatatttcc ttgaaagact tctttccata gcgctctgat 2580 tatgctgttt gggattaaca gaataggcat agcggtttag ataggaaatt ttaaaaatga 2640 caaattaaag aatcctggaa aatacactgt acattctgcc aaggtttatc aatatggatg 2700 ctggtatagt aatgagaata aatcggtaaa ttcttttcat aaaatgaagg aaagaaatta 2760 ctatgtgctc tttaaaatgt gttgcatcag tgcctgattt gattgtaagg gtcacatctt 2820 caagacatgt gataccaccc tttataccac attatagcat tgtctaatgt tgtaaagttt 2880 ataaattgct ttcactcagt cttcatctga ttctcagaat gaccctatcc aattgggaat 2940 atgggtttca ttagtcttac attactaagg agattcagag agtctcaatt ggccaacatc 3000 atgcagttaa aaatgacaaa tggggatttt gaacccaagt cttcctgacc ccagaacccg 3060 tgatctttgt actacatcat gcttcctgag aaattaaatg gacctgtctt gcagaactgt 3120 tcttcttcta actagggatc tggaggagtc tcaagtaaat aggcagatgg ccttagggag 3180 ggatgtctgg aagcacctgt ttggagtccc agcaggttgg tggttttctg tctgtaggtc 3240 tggcagctgg gcatggtaac ttagccatgg aaaggggctg caagaggagg tcctcagtgc 3300 tcagacccag ggcagaggac tgtgtggctc ctgtttgttt ctccagatct actctctaca 3360 cgccttcacc ctgctctctg tttgggatgg aatcaaagga cccctttgcc ccctggctta 3420 tggttgcctt ttgccaatgg aagcagtgac agaggatcag attagaggta gaaggggagt 3480 gaggaaggag agtgaagagg gataaattct ccttctgcct ctgatcctct gtcgctgctt 3540 ccactgccac ctactgcttc cattggcaaa aggaaggatg ccgtgaggtt gccatgagca 3600 tgctgcagcc ttccagtctc ctataagaca gcttccccat ggggtccttt tcctattcct 3660 cctcttgccc cttctgacct agccccaggt acagtactgt attacttacc ttctcttata 3720 ccttttccat acctttgtcg atggtctcct tgttggactc ctcacattac ccagtttgag 3780 tgtgctttct atttcctgat gggctcctgg ctgatcagac ctgaccccag aggacctggg 3840 taccagaatc taatgcctgg attaaggcac atgagcaaga cgcagaccct gcaaatggaa 3900 ttgaaattac aatgacctag aacaagggag atagggccaa gcatgcccta gtgaacgagg 3960 gacccaaatg gggtaggact gggaagaaat ctgacttgag actgatgggc taggactctg 4020 ctagaagggc ccttctggtc ttccaggaga caagactatt cacagacgct gcaaattggt 4080 ggtgcaagga aggcagcagg agctcaatag ggtacagagt ctaaggagag ctggaggcat 4140 gaaccaagca gagtggctgg gtgtttgaat ccttgcttct agtggcagag actgaccggc 4200 tattcatcga acccattttt atttcctcct gggcacatgg actatggtcc tcgtgttctt 4260 gagttctagc caatggaatg tgggcagaag ggatgtgcta gcccttaaac cttccttact 4320 ctctcccacc tcttgccagc tgtaaggaag agtcacagta acatctatta tttacttatt 4380 cattctttca ttcatttatt tcattcactc cctgaaacaa gagccaaggg tacagcctct 4440 ctaggaggtg actctcatgc ccttttatta tgctggcttg atactaatgg agatgcggtt 4500 gaccattgca aaaacccctg ttgagacaca gcagagttgg ccagcattct tatggtactt 4560 cggatgtgga tcctgtgatg gctacagcat aaaacactgc attagcctcc atcttctatc 4620 ctttttccct tcaaaaatga tgatcatttc attgagtgcc caccctgcac caggtgcttc 4680 tgatacttta tgaaatatga tgttttaaat atgaaaatgg gggcttacat aatgctgtga 4740 ctaatttgag ccttgctcag cagttaggca gcttcaatct tcttattaat atacagggag 4800 tggttgctga taataggcac attttcaagc ccaaaggcat cttgacagtg catgctgagg 4860 attgggggaa ataggaaacc tccaaggaat actcctgata tctttgcatc tgtatacaca 4920 tatgagttgt cttagtgttt ttaccataga agatccttaa aagttgacac aggcaggctc 4980 tgggtatgtg catcgagaga tatttcccag agtctgtttt tttgacatcc tttcaccatc 5040 attttatctc ttagcaggaa tcagttgccc aacaactcct gtgatcatct gcaaacctct 5100 ttacagtttt cagtgtctca aggtaataca taaagaagga agaaacaaaa gagtatgagt 5160 atcactattc atggatacta attaccaaat gtactttttt gaattaaatc cttgtttgaa 5220 tggaggttgc acagagatga atgttttgtt agcagacttc tcgaggccat ggcaggttta 5280 aataattttg cgccacggga gacaaatttt cctgatgttg gaatcctaat gtgggtgaac 5340 catgtgaaat gctgctttca gcaaggagct gacttcccag gctccctttt ctgagggagt 5400 tgggcagagt tggggtggtg acagtatggt ggaggcagaa gcttctatgt cctgattccc 5460 ttgtactaga aatttcatta cagatacttg tgcacatcag atgcattgtt ggatcagagt 5520 gtcgcatgtt cgttccttca cagatgttat ttcagattaa gccacagaca gcggggagtg 5580 gacgtggcat gcattttcct cttcatttgg tagcgtctca tctcccagca gtcatttgca 5640 gagcaacatt acttgcataa caattgagcc gatctgatat tttaggttat gatgtcaaga 5700 tatattatac tgcagcctac tgactttata aaaaagtagc caaagaaaga aaatgattag 5760 ggccgagttg ggattgaaag ggacctgagg gaatgtcata tgttatgaga atcttaaaag 5820 cttctaatga cctgttattc cccaagggcg cttgctactg tgacgattga atttattttg 5880 tactaaacaa gctttgcatt taatgccatc tttttttatg gtctgagacc cacaagaatg 5940 tgttttacta ttttctgaat aaaatacttg gtcaacagtt tatcatgcaa tcatctttct 6000 ttatgcttcc atgactatat ttagtaatac tatattttgt attattaaat gtatttatga 6060 attcttctgt tataatactt ttctgtttaa ggatgtttga cagtgtatat cttaaaggcc 6120 aagtgtcatc tttgcttttg taaatatatt ttatagtctt aaactgaaga tgttgtttgt 6180 gagcattttc atggcataga atgtatgcac aaagcttagg attaaagtaa gccttttaaa 6240 aacagcaacc gtgattatca ccaaatcaca gtgtttttag ggtaacatgg actatggtcc 6300 tcgtgtgctt catatgaata atcccacctc ccttctacct ggtaagctct atgacagaag 6360 atgctgtaca taacaggtat tcaataaata tttgttggat ggatagatgg attaatggat 6420 gaatggatgg aggaagtaga tatgtgtgtg atttggggtt gagggccgtg ctttttctgt 6480 gagtccagac ttaagtcagg ctgttttgca tcactgagct tcacaaacat ttactggaag 6540 tcaatgtcct gctgttcatg tgaagaaaca aaagtgcaga gggctaatga actcttagga 6600 ggatggcact gctttccatt aagcaaagcc agcgtatttt tggcttagaa aatgagttca 6660 aatttgaaat tgctttctcc aaaatggttg cagtctttca aattacagaa ctctcctgga 6720 aattggagaa taaataaaaa tgcaaggatc cttgctttgg tgagtaagct cacaaggatg 6780 gaaataggca caaaaagtgg cagtgtctct gaattatcac tgagtgtgag tttctaagag 6840 aacaaatcac tttcacgcag ccttgacaat cacttggtta gctcaacccc aggaaaggct 6900 atgaacaggg ctgggaagca gaaataatgc attattttgt tgagcttatt aacatttggg 6960 cagaaaggat agattccttt tacatagtta ggcatcattt taacatgtac attataggtg 7020 gtggcttttt tgtaacagaa ataagtgtag ctatccctta acaggagcaa tttcccttca 7080 tatttcttgc agctcttgtc ccatgaggcg acagatgagt atgtgatagc aatactgatt 7140 ccagtgctga gatgccatct gatccactgg gagagctggt ggattcaaat caatgtcagc 7200 tcatgccttc tgggcagcag tctttcagtg caggatttac tctatggatc agaaaaacag 7260 ctggtgactt gcaatatatt atacaaaaga cctttaaaat gttttgttgt ttccagctat 7320 gatgtagtgt gagtcacttc aatttttttt atttgtgtgc ctttctgatg gaacaaaatt 7380 ccgttaagca actggtaaaa acataatagt aatttaaact ggtgtctgta gaatattgag 7440 actgaagagt gattagaaat aaggttttac tttaatgtgc atttttagtg taaaaatttt 7500 acccatggaa agcatttatt ggaaatcctc tcctgagatt ccctgtaaaa tataagcata 7560 tgccaaagcc aataatcctt gtgggttact tggaattatt ggaaaagaat aatttttacc 7620 gagttatttt gctaagttgt gggttacagt tatttgtttc cagggtatat tgtttgtaca 7680 tgacagaatt ttggactttc ttctttcctt taggtcaagt tttttcccca taaaagatgt 7740 ataataattc atattaacat taaaacattt attttgggag gaaatactca atgcttttag 7800 tcccagaact agtcttcttt ccctcactga gtcatttttg gtttttatac tttggttttt 7860 catgggtttt tttaaatgag gtttctttct cactttaaaa aaaaaagtat tttctgtctc 7920 tgtagtccaa gtttctggta acaattagga tcactagtac agaaatacaa tgtatgtcta 7980 gaaaaaggta caaaaataaa ctagcaagat tcttggatgg tctggatacc taaaagacaa 8040 gggatttgaa attttctgag tgtttggtga gtccagttag tggctatttg gtatcaagtg 8100 ggtatcccaa atctgatgtg attagccaaa tttccacacc aatcatccag agccaatgcc 8160 agaatgacga cctcgcatac atcaattcaa tggctatggt ttcccagttg ctttctgtag 8220 ttctctgttg aatactttaa tgaaataact aaatagacgc cagccatctt gggcatctct 8280 gtggatgaag agctatgtga aatactatca tactcaatat ttgtaggggg tgagtcttaa 8340 gtctgtggtc ctgtcaagga gttcctcact acatttgact gcaagcataa ttagcaattg 8400 gtgttcagtg tgcaaggaac tttgattgat tgggctgtgt tttaggcctt gtcaacatga 8460 acaaaacata tcatcaggtt cgtccatctt gcttagctac ttttatatgt acttgaatat 8520 tccagcaata ctaatttcca ctgatcaatt aaggaagcaa tcctaaagga agatgagatt 8580 aaaagaagga aaaagaatca caaaccaaaa gagcatttcc tgaagtgtgt ccaagaacac 8640 taattattgg agaagttatt aagatttggg ttggggggag gtgggtaacc cagtgaaata 8700 agtttgagaa atgctgagat aagccaagtt agcatttttt tcctatattt tagggctcat 8760 cagagctttt aacatgccat gaacattata aatctcaaaa agggagacct agcttcccca 8820 acttaatgga acacctcctc tacatcccac catctgattt ttttccccaa agaatatttt 8880 gaaaaacaac cttttgggat gtttgcttaa tacatgtgga cttaaaatta aataataatt 8940 ataaataatt aaattcagtt gtgttcttgg catcataaat ttatttgact tatcatttat 9000 tgaaagcctg ctatgtgcca gacactgagc taagtacttt tacatatatt aaaattgtaa 9060 tagccccatg aagtaggtgc tattttacca ttttaatgaa taaggcactg aagcttagag 9120 aagcctggtg attttcccaa gtttgcagaa gtaggaagta gtgaaggtag aatccaaact 9180 taggccataa ctgataacca tgatactata acaaatagtc taaataaaat aataaaaatt 9240 gtgtgtttat gtctgtaaga gaaagctgga ccacagcttt ttagatccag agaaaggtgg 9300 acctaaaaat tttcaggaat tattaaatcc agttctcaat gtttagagac ccagaacagt 9360 gatatcattt tctaatgata caccactaat tgatgaacag gaaggagctg gaaccatact 9420 ctttttgact ctttgatgat aagatgccac gtcattcttg atggcttttt aattagttga 9480 cttcagaaaa cgaaacaaga taatattgct tttaaaagtt tagatctgtt ttgttagtag 9540 attataggaa tttgctatta ggttcattgt ttcatgatga aacattgcaa atgttcattg 9600 gaaatgtttc ataccaaaaa acagactata aataaaaggt tatttaaaat atttaaaatc 9660 atgtgagtgt gaaggtgagt gagaaaatat agtgtccagg aaaagtaatg tcaaacaata 9720 gcatttgaat aataaatgac tcaaccgaag tagaatatag gctttttttt tcttgaggat 9780 caaagcacaa cctcagcttt atttataggg gtaatagtca tctctgtagt gtgaaatgaa 9840 atggggcact attatgttgc tgcacagtct aaatttctac tcttacatac attatattac 9900 attaaggcaa tatgtttcag tagccatctg tttaaatgaa aataactctg gagcagaaat 9960 acgtaaagca gtttctcaaa tattaaaccc agtctgagct tgggcttggc atatctcttt 10020 ttattggtgt caggaaatat aaaagataaa ttttgatggg aggaggctca tatggaaatg 10080 gtcagaaaat gaaagaatgc ctggggcagg cagtctaagt acaggcagca atttatccca 10140 gaagaaagga atgtaggaag tgaggtcacc cagaggaaag atgatcctag gagatgctgg 10200 atggtgctaa agacagtatt caatatcgta actttcaacg atataatcca atcttaggga 10260 ttgcctcttt accatagaga aacatatatt tacaagcctc tcagcttttg taaattgtta 10320 cacttttttt aaatggttgg gtaaaggaaa gtctggagga atctaactct agcactgtcc 10380 ttgagcagct ctcatcaagt ataacagctg ctgtgtatgt aagagaagtg ggggatgact 10440 gggaaagttg ttccagtgtg atctcctgaa atagatagaa gacttgcaat ttcacaccaa 10500 gatccacagc ctggccttgt tttctagttg cagatctgaa gtagtagtag tccatctgtc 10560 agcctgacat ctttttatgc tccctttcaa tcactcccag aggaaaaaaa atattttaga 10620 ttgattctga ttttggtaac tttcttatta cctatcagtt taaaaacatt aaaagatagt 10680 agcagatttc attttctctc atcctgcagg tttttaaagt tggaatttta cccattctat 10740 ttgggtccta ggaatagtga tataactgac agacagctga ctaataaatg aactggagaa 10800 caactattct atttgtcttt acataaattc tttaaaaaat gatagaattg gtttattcat 10860 tcactaaaca gacatgaacc aagcgcataa cagaacactg gaaagttaaa ttcctatgag 10920 ggagatgtca ttctgggctg aacaaggctg tgcaagaaga aaagggacca agaatctgac 10980 taagaatgaa gatgatgatg ggcacccttt gtggatgcaa agatcagtag aataggtgtc 11040 ttgcaccaga tagattcaag tggaaagagt gatgggtgat tcaggaaaat cctcaagggc 11100 caggagacta attaaggtca agtcctgtgg agagcaaaat ccaggagatg tatcatcatt 11160 tgccatatga ggaagtgggg atttgctacc tcagatccca aaaaaagaaa ctctttgctt 11220 tccatctcac tttgttttgt ctattgtgtt aggatgatcc ttatacatga aaaagctcaa 11280 aaactgactc aagattccag gttttggaag agagccattc atgcaatgcc aaagtacaca 11340 tcaaaatgtg caacagagag tgtggagtga caccatcaac taaagaacta gtcaaagttc 11400 ctacgagcat ggcgccatac agccaatctt ccttcttggt tctcagtgtc ttcgagggta 11460 gctcaaaggg tcactgtcac agtgaccatg aattgtacag gaatcctgta gacagtgaga 11520 agatcaagcc ttaagaaaca ccacatttat ctatttggag gtagagtact gtttgttttg 11580 gtttgatttg gtttttattt gatttggagg ttttggctat aaaagagtgt cattttgtga 11640 ttcagaaata ctcactcttt aaaatgttag tttcattttt agcgtcctca cattcttttg 11700 gttcctttta ttggaatccc atcttataac ctaatcctat taatatttat agggtccaca 11760 tgaatatgaa attaactagt aggttccatt tatgaaaagg gatcaactat taagtcctat 11820 attttgttct ttaactttgg aatttgattc atgatatctt gtaaagcttt gaagtcaact 11880 gacagtatga cagatttaca aacatctgtt tgaatttgga ggcctttcca tctcttctga 11940 ttgaaagtaa ttatactcct cttctgcacc tgttgcattg ttttatgttg tcatatactc 12000 gttgagtgca tgtacacgta tctgtcacgt cacttagatt gaaagcttct tccagccaga 12060 aatttgtgtc atttgtcttt ggatcctcag tggtaatcag agtctggcat atagtttatg 12120 ttcagtgtat ttctaaggag ggtagattta aggagggtag agatgacatc atcatagtaa 12180 taaataagag taacttttct taaagactgg atttctatac ttgggaaatg gatattactt 12240 tgaaggggag aagagagtga gagcaagagt gagaaaagaa gaaaatgaat ggagttcatg 12300 agtacctagg agttgtttgg ctagaataaa acaagtgttt cattacagga aatgaagata 12360 atataaagag cagcttaaac ttttttttag tggactaagt tgagaatcct gtggagtgta 12420 gagttttcat gtctgggtag tcatgccttt cttatagtta tggagggtta ggtatgaacg 12480 gggaacattt aaccatctga attgaccata ttaaccgaaa atggcagtaa agtaaccata 12540 aatgccaggg aagtaaccat gcctacctag gacacatcag tgataagaaa atgcttcttt 12600 caacttttta acagatttat tgaactgtaa tctacatacc ataaagttca cctttttaaa 12660 gtgtacaatt caaaggtttt tagaatattc gcaaagttgc atacctgtca ctgtaaccta 12720 attttagaac aatttcatca tcctctcccc aaaataatca ctgcccattc tcccctcact 12780 tagtcccaaa tcctaggtaa tgactaacct acttttctct gtacatttgc ctattccaga 12840 catgtcatat aaatggggtc atataatatg tgatattttg tgactggctt ctttctcttt 12900 gcataatgtc tttgagtttc atctgtgtca tagcatgtat cagtactgca tttctttttg 12960 ttgtcaaaaa attccattgt gtggatatgt cacattttgt ttaataagtt gatgaacatt 13020 tggatttttt caatttttgg ctattataac cactttgttg aaatcaataa accacaaatg 13080 tatgggctta tttctggact cttaattgta ttctattgat ttatatgcct atccttatgt 13140 cagtatcaca gagtcttaat tactgtagtt ttataataag ttttaaagtt tggaagtgtg 13200 agtgcttcat ctttgttctt tttcaagatt attttggcta tttgggttcc ttgcatttct 13260 atacaaatct taggatcagg ttattatttt atgcaaaaaa aggcagtcag tatttttata 13320 aggattgcat tgaatctgta gaggaattta gagcatattg ccatctttgt aatgtcaagt 13380 gttccagagg agtaatgtca gcaaaatgga ggaatatagg agctttctac cctcatctcc 13440 ctacagtgca ccaatttaga cagccaccca tgaaaaagat taactttgtg ggagtctgag 13500 agtccagaga agcttcagca tgttcttgga ccaaaaatct aagaagtgat gcactgaaga 13560 aggtaagaag aacagtttca ttttacccac attactcctc ccccaatttg gcataggtca 13620 gtgacaagag agacccacgt ggtccacaag tttctcccat gaagggaagt aaaaagcata 13680 gtgaatgagc tcccggcctt cccagctgtg caggatgcac tcaagaggcc tatctctttc 13740 ttgccccacc cagaatactg aaaaaaaatc agcataactg agtagctggg ggagcctggg 13800 agcagggaag agaggaaggg attcacagca actaaccagg aaactcaaca aagggccatg 13860 taacctacta accgtcttct cagattccat caggtagtcc acttaaaagc catttgggat 13920 gcctcaacag cacacccact ccaaatgtcc ccatgaggac ttccaatgtt tgtcatggct 13980 caccttcaca cacactctgt gactggatcc ctgtgcattt ccctctcatc ccctccagtc 14040 ttcctcccaa tgcacagtga gtgtgagcct ttgcagatgg cttgggagcc tgcacaatca 14100 gccagcttgc ctctgcaaga ctgggagaag gcacataaac ttgagcattt ttttccctag 14160 ggcatcaccc tgaggaaaaa agcagaggca ctgagcatcc actgtgactc agtgagactg 14220 tgagaaggca tacaatctta agatacgaaa gagaagatga gagtgggttg gatgcatcca 14280 tagcaaaggt ctgagactat gtacagtggt tcatgcctgt aatctcggta ttttggaaag 14340 ccaaggcagg aggatcactt gagcccaaga gtttgagacc agcctgagca acctactgag 14400 accctgtatc tacaaaaaaa tgtttttttt aattaactgg gtgtggtggt gtgtgtctat 14460 agttccagct actccagagg ctgaggcatg aggattgctt gagcccagga ggtcaaggct 14520 gcagtgagcc atgattacac cactgcactc cagcctgggc aacagtgcaa ggccttttca 14580 caagaaagag agagacagag agaggaagaa agagagagaa acgaagaaag agagagacac 14640 agaaaggaag gaagaaagcg aaaaggaagg aagggaggga gggatccaga gaatacctag 14700 ctgggctgac tggccaagtt atttctctcc ctaagccagt cagtaagaat tagaggaagt 14760 gactgcttat ttaaatgcaa agacagcagt acaaaacttc aaggaacatg aaaaactaag 14820 gaaacatgat atcatcaatg gaacacaata aatttcccat aactaacccc aaagaaagga 14880 agatttatga attgcttgac agtagtattc aaaaatcatt gtttaaagaa ggctcagtga 14940 gctataagag aagcacagac aactaaaaaa aaaaatcaga aaaagtacat aagcaaaatg 15000 agaagctttg ttttgttttg ttttttcgga gatagagtct cactctgtaa cccaggctgg 15060 aatgcagtag catgatctca gctcactgca acctcctcct cccaggttca agcgattctc 15120 ctgcctcagc ctcccaagta gctgggatta caggtgccca ccaccacgct tggctaattt 15180 ttgtattttt agtagagaca gggtttcacc atgttggtca gactggtcgc aaactcctga 15240 cctcaagtga tccacccgcc ttggcctccc aaagtgctgg gattacaggc atgagccacc 15300 acacccagcc aagaagttta acaaagaaac agaaataatt aactaaacaa actcttggac 15360 acaatgaatg aaataaaaaa tgcaatagag aggcaacaac agacttgatc aaacaaaaga 15420 cagaatttgt ggactcaaag acaggtcact tgaaattatg cagtcaaagg agaaaagaag 15480 aaaaaagaat tgaacaaaga aagcttatgg gatttacaag tcaccaccaa acaaaagaat 15540 atatgcatta taggagtctc caaatgagaa taaagagagg aaggaaaata agtttattta 15600 aagaaatcat agctaaaatt tttccaagtg cagtgaaata tggacatcca gatacatgag 15660 gcccaaaggt tcccaaacag gttcaagcca aaaaaaactt caccaagaca tattataatc 15720 aaatgtcaaa aagcaaagat gatggatttt gaaagtagta tgaaaagaga cctatcacat 15780 gcaaggagac cttcattaga ctgtcagaag atttcttagc agaaacccca gcagaccagg 15840 aaagagtggg atgatatagt caaagtgcta aaagaaaaaa aaatgccaac cagaaatact 15900 ttatctagca aagctgtcct tcagaaatga aggaaaaata aacatttttc cagacaaaca 15960 aaagctgaag gagttcatca ccactagact tgacttacaa aaaatgataa agggagttct 16020 tcaagctgaa atgagaagac actaattaat aacatcattg gtcaaggtaa gtaagagtaa 16080 gtaagtacag tcaaattcag aatactctaa tactgtaatg atgatgtata aatcactttt 16140 agctctagta taacagttaa aatacaaaag tattaaaaat aactatagct acaataattt 16200 gttaatggat acacaatata aaaagaagta aagtctgaca ttaaaaacat aaaatgagaa 16260 agtaaaagtg gagagttgtt gtatgcaatt gaagttaagt tgttataagc ttaaaataca 16320 ctttataact ataatatgtt atatgcaagc cccatggtaa ccacgaaaca aaaacctata 16380 gtagaccaca aaatataaag ataatcaaaa catacagtat ttttttaaaa aatcatcaaa 16440 tcacaaagga aaatagcaag agaagaagaa aggaatataa gtaagaacta caaaacagtc 16500 agaaaaggat tactaaaatg tcagtagtaa gtcttttcat atcaataatt actttaagtg 16560 taaatgagct aaattctcca tttgaaagac aaagaatggc taaatggatt ttttttttta 16620 atctgctacc tagaagagac tcactctaac ttcaagttac acctaggttt atgtgaagga 16680 ataggaaaag atactccatg caaatggaaa ccaaaagaga acagggtaac tatactaata 16740 tcagacaaaa aagagcttaa gtcaaaaatt gaaacaagaa accaagaagg tcgatatata 16800 ataataaagg gataatttca tcaagaggat ataataagtt tatatacatc taacatcaga 16860 gcatctaaat ataaaagcag ttttaatgta tctgaaggga gaaatagaaa gcaatacaat 16920 aatagtagag gacttcaata ccccactttc aacaatggga agatcatgca gtcaaaaaaa 16980 ttaataagga aacattggac ttcaactata ctttagacca aatggactga acatacatat 17040 acagaacatt tcatctaaca gcatcagagt acacatgcat gtcaagcaca catagaacat 17100 tctccaggat ccttatatgt gtcttagccc ttttgggctg ctataacaaa atgccataaa 17160 ctaaatggct tttaaacaac agaaatgtat ttctcacagt tctggaggct gggaagttca 17220 agataaaggt ggcagaagat ttactgtcta gtgagggtcc gcttattggc tcatggacag 17280 ctgtcctcac taatggaagg ggcaagagct tcttatataa ggacactaat cccattcatg 17340 agggctccac ctcatgacct agtcacctcc aaaaggccct ggctcctaat tatcatatca 17400 tatcataaaa tgtattgatt attacatttt aacatgtgaa atgtagggag gcataaactt 17460 tcagtttata gcaatatatt agtctacaaa agaagcctta acaaactcaa aaatattgaa 17520 atcataacaa ttatctcttc caaccacaaa agtaagaaac tagaaatcaa taacaggagg 17580 aaaactggaa aattcacaaa tataaggaaa gtaaacaaca tatttctgaa caaccaatga 17640 gtaaaagaag aaattgaaag aaaatttttt aaaaattgaa ccaaatgaaa atagaaactt 17700 aacataccaa aacttatgag atgaggcaaa agcagttcta aaagggaaga ttattgtaat 17760 aaacacctac attaagcaaa aagaaagatc tcaaataaca acctaacttt aagaaaccag 17820 agaaagaaga acaaactaag cccaaagtta gcagaaagaa gaaaataaca aagattggag 17880 cagaaataaa taaagactag aaaaacaata gaaaaggtca agaaaactaa caattggtgt 17940 tttgaaaaac agaattgaca tgttttgaaa aacagaattg acaagccgtt agctagacta 18000 agaaaaaaat aagaaaagtc tcaaatacat aaagtaagaa aagaggagag attacaactg 18060 atatcacaga aatacaaagg ataagagact actatgaaca actatatata agcaaattgg 18120 ataacctaga agaaatgaat gaattcctag atacatacat cctatcgaga atgaatcatg 18180 aagaaataga aaatctgaag gtaccactaa taaggaggtt aaatcaccaa tcaaaaatct 18240 ctcaaaaaag aaaaagtgag gaccaggtgg cttcactact gaattctttc aaacatttaa 18300 agaataagta atagcaagtc ttctcaaact cttcaaaaaa attgaggaga atgggaacac 18360 ttccaaacgc attttacaag gtcagcatta ccaaagacag acaagaacac tacaaaaaaa 18420 gaaaactgca ggccaatatc cctgatgaac atggatgcaa aaatccttaa caaaataata 18480 gcaagccaaa ttcaacagta tatgaaagaa tcatacacca taatcaattg aggtttgtcc 18540 ctgggatgca agcatgattc aacatagaca tgtcaataaa tgtgatacac aacataagca 18600 gtgtgaagaa taaaaatcgt atgtccatct taatagtcac agaaaaatca tttgacaaaa 18660 tttaacactc tttcctgata aaaactctca acaaactagg tataaaaagg aatagacctc 18720 aacataataa aggccatgtg tgttaaaccc acagctacca tcatcctcaa tggtgaaaag 18780 ttgaaaccgt ttcttctaac atcaggaaca agacgaggat agccactctc atgtctattc 18840 aacagagcac tgaaagtcct agccagagca attagatagg aaagaaataa aaggcattca 18900 gattagaaat gaagaagtaa aattatctgt ttgcagatga catgatctta tatatagaaa 18960 accctaaaga tgccccaaaa aactgttaga actaacaaat cagggctagg ccctggaaac 19020 ataaggagga agagaacact agtccctgct ctctaggtgc tcatggccta gtggggaaag 19080 catggatcca aatgaaaatc acatcatgca agaaatgcca tcaatggcat gactaggtgt 19140 gataaaatta ctgttaagag agtgattggt ctgactcaga tagttagata acgtttgcat 19200 tgatcagagt ttagttcaat ttttaagaat gtgagaaata ggcatgggca tactgtaatt 19260 ggggaccagt ctgttgccaa ggcacaggca ctatgggggt agggaagttg gaaaggtgga 19320 gaaagagtgg caagaaatga gtctaaaatg atagcttccg gctagaatgc catcccaagg 19380 aatttggagc caatccaggg ggcaataaag agcattgcag gtctataaac cagaagacta 19440 gtaagttcgt attttgtttt agggaactga ctctagcagc cccatgtcgg aaagattgga 19500 ggaaagagat gaaaatggga gatggtgaag gcctgagtta agacaatggc agcagggctc 19560 atagaggagg gggtaaaact gagacaatat tgttgatgta gctgggatga aaactgaaat 19620 gtgtcaaaga tggagtcgga aattagaaga taacatagtc tgatgggaag aacagtacat 19680 gaagtctgca aatctggact caagttccag cttagctgtt aactagctgc atgtccttaa 19740 ttaaattttt attttatttt attttatttt attttatttt gattttgatt tttttgagat 19800 ggagtctcgc tctgtcaccc aggctggagt gcagtggcgc gatctcggtt tgctacaaac 19860 tctgcctccc aggttcaagt gattctcctg cctcagcctc ccgagtagct gggactatag 19920 acacacaaca ccacacctgg ctaatttttt tgtattttta gtagaaacag ggtttcatcg 19980 tgttggccag gctggttttg aactcctgac ctcaggtgat ccacctgccc tcagcctccc 20040 aaagtgctga gattacaggc taattaagta tttaaccact ctgttcctgt ttcctcagct 20100 acagagagac tgagtagatt atctcacaga ttggcttcca gaactaaaat acaaaactaa 20160 aaggaagagg aggaggagaa ggaggagaga aattgagaca atttatgtag atatcatcca 20220 agataaagat gactaaagaa acagagcaat tggaggatta taatttaaga gagttttgtt 20280 tttaggagat aaaatgtctt gtagaaaaag tttacataac acatttttag gtgttcagga 20340 tatccaaatc ctggcacttg ttcttcttac ctacagggtt ctctgccaaa gaacacctac 20400 aaaaggatca ataatcgaat aagaaatcca gtgtaaattt tatcagtatc tgaatagttc 20460 cctgaaaatc caagggaaag ctggatggca ggcataattt gggacaaaga aggaatggag 20520 tctcttatgt cccatccaaa atctagacct tgggatccta tgctcatgtg tgggagaagg 20580 tgtataggca catacactct catgttcaga gagttggtgg gtggagggag agggaaaagg 20640 tgagcccaag gacagcagag agaaagaaaa agaacctaaa tatatgggca tgctcacctg 20700 tccaatatca ggctgaactg agcccagaga tacccattat atttctgtgc aggattactg 20760 atcactaggg gaaacatggc cccataaata acagatttaa tcagataagc agctcctctc 20820 ccatgagaac tagttcagaa ctaaagtaaa gagctggctg tgagggattc atccaagaat 20880 ccactgagcc atgcaaggat ggatgttttc tcttatgagc tgagatagaa agctgggaag 20940 agaagcgaag tgtctcatcc ttacccaaca gtattatttt gattcttcaa tttttataat 21000 atgatatcct ttgatggtgg gaactatgtc ttacccatca ctgctcctag cttactgaac 21060 tacagtgaat gttaattgaa tcagtaaata tattaataat caggattgac tggatttaaa 21120 taagattatt gcaactcaaa gaatcctcgg gagggcatca tccatcttca ccatttgtta 21180 tgaactcttc atgtgtatta attcatttaa tgcaataaca ctataaggtg ggaactatca 21240 tcattccccc attttacaaa tgaagaagct ggggtctgga ggacccatct cgccccatca 21300 cacagttagc aagtggcaga acaggaatgg gaagccagat attagataca gaatttatgc 21360 atttgcaacc acacacactg ccagccaaaa acatgctttt cctctccaag agcacaaccg 21420 ctagctttcc ttattggctt atgaaaactg gaaacccagt ttttaaaaga ctgtgaaaaa 21480 aaattaagcc aatatgctta tcattttaaa aggtactcta tttaattgag gatatatgtt 21540 ttcatacttt tattcccaaa tggttatcac ttccttaatt aaataataca tcaattatat 21600 ttgtctataa atatgtatgt gtatatatac atgtgtgtgt gtgtgtgtgt gtgtaccagg 21660 ccctcaataa gtatttgctg aatgtttctt ttctgcaaaa tctatgtata ctaatgtttg 21720 ctaaattagt atacacagtc tttctactgc tgtttagagg gaaggtgcga tgatttccca 21780 tgtttttaaa atcagatggt tcaatatatt catgccacat ttagagaaga aagcaattca 21840 cggtagagta tgaactctca aagactttaa gtctcaatgt aatttatcaa ctttatatat 21900 caacaaactt ttatttagtc ctctctgtat ataaaaagct tattagcgat cacatgctaa 21960 agcagatttt taaattgcta gagccttaaa atgcccacaa tatagtccag aaagaagaca 22020 tgaataaaat tggattatgt agcatagcat ttaagggctt attcacactt tatgccctcc 22080 ctcttctatt cctacctatt cttctagcac acagggtcag gtcctttcca gctgcctgtc 22140 tttcctcatg ctacgctggc acacttggcc aatgttggtg ccatgaagag gttactcatg 22200 cagataggaa gctgaggagg aggttttaga aagaagctga tgagttgagt gatggacacg 22260 ttgagtttag gtgccaatgg gaaagtacaa gtaaatgtat tgaagcacaa ttgaataata 22320 atgctttaac aatttgataa ttatgtgtgg attaagggag agggaaagtt ttaagcctag 22380 gatattggaa gaaggatgat aaaaaagtag gaggtcagtg ggaaagttga tttgcagaga 22440 aagatgctga tattagtttt ggatttgttg cacttcagaa gatgatgaga cattaaaact 22500 gatattgata atgtaatctt cacgatgaaa ataaagtaga gattgaggaa ctgatccaga 22560 ctgaaggaga ctagagagac ccggaattgg gtgcaaccca ggatcctgga gcagtgcttt 22620 tgctatgaag gacgggattg agccaattgg caaaacttga ttgcatcttt gggcaaaggg 22680 tatccaggtt ttttaaatca gatgattaaa tagtatccat tgtatgattc ttataatttt 22740 tctataagtt tgaaatcatt taaaaataaa aagcagaaaa aaacaaacat caccactttg 22800 gcaacaaaaa gttggcattg tcaatatatc ttaagatcta cattagatat gtaagatgtc 22860 tgtatcttaa tctagatgtg tgtgttcaca aactttaaac tagtaattct actttgagac 22920 actatcataa agaactaata atttataggc atacttcatt ttattgtgct tcactttacc 22980 gtgcttagca gatattgagc gttttttttt tttttttttt tttttacaaa ttgatggttt 23040 gtggcaaccc tgcattgggc aagtcttttg gtaccatttt tccaacagta tgtgctcact 23100 tcacgtctct gtcacatttt gggaattctt ccaatattta aaactttttc attgtatctg 23160 tgatctatga tcagtgatct ttgatgttac tattgtaatt gttttggggt accacaaacc 23220 atgcccatat aagacagcaa acttaatcca tgaatgctgt gtgttctcct acttctccag 23280 tgactagtca ttctcatgcc tctctccctt tctccaggcc tcctttctcc aggccttctt 23340 attccctgac acacaacaac attgaaatta ggccaattaa taaccctaca atggcctcta 23400 agtgttcaag tgaaagaaag agtagcatgt ctctcacttt aaatctgaaa gctagagatg 23460 attaagttta gtgaggaagg catctcaaaa gccaagatag gctaaaagct aggcctcttg 23520 tacccaacaa caaaattgtg aatgcaaaag gaagagtttt tgaagaaagt taaaagtact 23580 actccagtga acacacaaat gattaaaagt ggatcagcct ttttgtggat atagaagaag 23640 ttttagttat ctgggtagaa gatcaaacca gccacaacat tcccttaagc caaagcctaa 23700 tccagagcaa gaccttaact ctctttagct ctgtaaaggc tgagagaggt aaggaagctg 23760 tagaagaaca gtttgaggct aaaagaggtt ggttcatgag gtttaaggaa agaagccatc 23820 ttcataacat aaaaatgcaa ggtgaagcag caagtggtga tgtagaagct gcagcaagtt 23880 ctccagaaaa tctagctaag atcattgatg aaggtggcta tgcaaaacaa cagatttacc 23940 ctataattaa ccaggcttct tcttcttctt cttctttttt tttttttttt tttttttttt 24000 tttttttttt tttttttttt tgagaggcag tctccctctg tcgcccaggc tggagtgcag 24060 tggcacaatc tcagctcact gcaagcccca tctcccgggt tcacgccatt tctcctgcct 24120 cagcctccca agtagctggg gctacaggtg cctgcaatga aacaggcttc tcttgggaaa 24180 agataccatg taagacttgc atagctagag agaagaagtc aatgcctggc ttcaaagctt 24240 cgaaggacag gctgcctgtc ttgttagggg ctaacgcagt tggtgtcttg aagttgaagc 24300 caatgcccat tgattattcc aaaaatccta gaacctttca ggatgatgcc aaatctactc 24360 tgcctgtgct ccacaaaaag aacaacaaag cctagatgac agcacatctg tttacagcat 24420 ggcttactga atattttaag cccactattg agaccatttc tcagaaaaaa aaaaaaaatg 24480 attcctttta aaggttactc cttattgaca atgcacctgg tcacccaaga gctctgatgg 24540 agatgtacaa ggagatgaat gttgttttca tgcctgctaa cacaacatcc attctacagc 24600 ccatggatcg aggaataatt ttaactttca agctctatta tttaagaaat acattttgta 24660 aggctaacct accatagata gtaattcctc tgatggatca gggcaaagta cattgaaaac 24720 cttctggaaa ggatttatca ttccagatgc cattaagaac atttgtgatt tatgaaagaa 24780 ggtcaaaata tcaacattga caggaatttg gaagaagttg ataccaaccc tcctggatga 24840 ctttgagggg tcaagacttc actggaggaa gtaactgcag atgtggtgga aacagcaaga 24900 gaactagaat tagaagtgga gtctaaagac aagactgagt tgctgcaatc tcacgatcga 24960 acttgaatgg ataaattgtt tcttatggaa gagcaaagaa agtgtttttt ggttttgttt 25020 tgttttttta agacagtgtc tcactctgtc acccaggctg gagtgcaatg gtgtgatcac 25080 aactcactgc agcctcaact tccccaggct caggtgatcc ttccacctca gcctcctgag 25140 taactggtac aggcacgtgc caccacaccc agctaatttt tgtatttttt tgtagagacg 25200 ggggtttcac catgttgccc agtctggacg tgaactcctg ggctcaagtg atcctcctgc 25260 ctcagcctcc caaagtgctg ggataacagc tgtgagctac catgcctggc cagaaagtgt 25320 tttcttgaga tggaatctac tcttggtgaa gatgctgtga acattgttga gatgacaaca 25380 aagtatttag aacattccat aaacttagtt taaaagcagg agcaaggttt cagaagattg 25440 actccaattt caagagaagt tctatcgtga gtaaaatgct atcaaacagc atcagatgct 25500 acagagagat cttctgtgaa aggaagagtc catcaatgca gcaacttcat tgctgtctta 25560 ctttaagaaa ttgtcggccg ggcgcagtgg ctcatgccta taatcccagc actttgggag 25620 gctgaggcgt atggatcact tgaagtcagg agttcaagac tagcctggcc aacatggtga 25680 aacctcatct ctacaaaaat agaaaaatta gctgggcgtg gtggcgcatg cctgtagtcc 25740 cagctactca ggagaagaat cacttgagcc caggaggagg aggttgcagt gagccgagat 25800 cgcgccactg cactccagcc tgggtgacag ggactcatcg aagcaagatc tccaccagct 25860 aaaagattgt gacttactga aggcacagat gatcattggc atttttagca ataatgcatt 25920 ttcattaagg tctatatatt gcttttttag atataatgct attgcacact tttagactat 25980 agtatagtgt aaacataact tttttttttt ttgagacaga gtctagctct gtcacccagg 26040 ctggagtgca gtggcatgat ctcatatcac tgcaacctcc gcctcccagg ttcaagtgat 26100 tctcctgtct cagcctcctg agtcgctggg atcacaggtg cacaccacca cacctggctt 26160 tttttttttt tttttttttt tttgtatttt tagtagagat ggggtttcac cacgttggtc 26220 aggctggtct caaactgctg acctcaagtg atctgcccac ctcggcctcc caaggtgctg 26280 ggattatagg cgtgagccac cacgcccagc cttgctttca tgattttaaa ggtattttaa 26340 atcaaaaggt caagaagtgc acaaattcag gattaattat ttgtatttag gattatttgc 26400 cacagcgttg accaaataat catttgtggc caaagttttt gaagaataga ctatagagag 26460 aggagatcag agtgggccaa tagggagcca tgcagtggcc cacatttgga aaaggagagg 26520 aatgtgctga gcggagttga cggataatta actagaaatg actgcactga aaagtgtgtg 26580 tctgctggtg ttgctgaaaa aggttggagt gtgggtttat cacatcccga aaaaggctaa 26640 ggagaagagg aactgaagaa aaaacctacc gattcactaa ggatttccca ccaagaggcc 26700 tcaataaaga caaactggct tttataattc aattcaaaca caaattattt tttaaattaa 26760 ttcctacggt ttgcattgat attttaacat gagaagtgga gttcagaaac tgcaacaaaa 26820 gggatttgag cagtgataaa atatttgtaa gcctctcctg atgaccttgg tactgaaaga 26880 gactgttctc ctgtgtcggg gaaggttctg gaccgccttt ccagcagcat tttatcatca 26940 gaaaacggct cacttcataa ggtttataac cttccataaa actgcagaac attttattct 27000 tttttcatta agccaccttt ggaatcattt tagtcccttt atagtctctt atttaatctg 27060 ttttttcgta gactaaaggg agaaaaaatt ctatcagtgg tcaaaatagt aattagatag 27120 tgtaagtcac agcctgatgg cttcaaggca tacatactta ctacttatct cctccatctg 27180 ccttcatcag tgaattcttt tactcccaag cacatcttta cctttttctt aaacaatgga 27240 aaaaagaaac taccaaaccg tgcattttcc caattataag agttactaat gtttatattc 27300 ttttctatta aagcatcatt cccatggtgt aaaagctctt ttaccaaacc ctaaggaaag 27360 catgaattaa taaaacatca agagatttta tttcctatat tgaaaactcc tatagttgca 27420 taaaaacaac tgaatctttt ggaaatacgt gtaatcacaa ggagaggaac attaaaagag 27480 agaaactcac tacaaaataa atcttaaaac cactttcatg tttaaaaaga agaaaatatc 27540 agttcttctt attcctgaag gatttttttt taaaaaaatc ttttaattaa tgacagccct 27600 cagggcactg agcaattgtt aattaaaaca aggagaaaag gaagaggaag taggcaaaaa 27660 tgctaagatg aacacgtttc cttttctctg caggggaata acattaccaa atgaacatta 27720 ataaatatga atactattga gaagaaatac atttaaaaaa attttaactc ccacctcagc 27780 ttgacacaca ctagcagcta cataaattaa ttggggcgcc tcgagaatta taaacccctg 27840 ggtgtcacct tttgtctaat tgagtattgg tagccatcac cctaccctca tcaggatgga 27900 ttgtttcttt ctcggtgcaa gctgacttct gtcagggaat agcgcctgat caaaggtctt 27960 ctaagggatt tcattcactt tcattcactt tcattcttgc agtgggcggg cattcacgta 28020 ggcaaccgcc atcattataa aacatttctt aaatgcgagt taggagctag actcactgcc 28080 cattcaattc attggtcttt ccctttgcag ccattaaatt tttacttaga aaaaaataat 28140 tatcagatct tttcgttcac cccctgtgct tacctaattt gggcaggtta ttagtaataa 28200 cattttcctg gtcgttccct accactttcc cctctacctc acatgaaaaa ggcttttatc 28260 tttctcataa gctcagaagt tcacttaaca agcagagctt tagaagccaa gaacaagaaa 28320 aaaaaaaaaa aggtaagaga atctgttttc tactttattt ggagggggac agaaacccag 28380 aatcccatag gctgtatgtt tagcatgaaa aaaaaaagtc attatttgaa attaggacaa 28440 ccagggatag tttttcccaa cttttaaatg atcccagttt tacgtaattt tatgggcttt 28500 tcatcaaagt tgtttttcaa aaatagaact caacccctta gggtttaaga gttttttccc 28560 ctttagtgtg cgtgcacaca cccctttgat gttccgcatg ctagcatatc agggtcagtg 28620 catgggggcc agtgtcattt acagaatttc tcagatgcca gctaagatca gtagctagga 28680 gacaacttag aatttcattt tgctctttgt tcagatacat tctttaccac agataagatc 28740 ttacctcccc agcagtctat ctctaaaaga acaaactcta ggtaatcaaa aagctatatt 28800 ctacccccca accaaaaaca aattgcttat tttagctaat acctagtcaa acataaatgc 28860 cagggtagaa aaaataatgt attttctctt tccttgctat aataatatat accagttgaa 28920 aactcctgat tttcctcaga ccacctaaaa agctttgtcc attgcttgtg ctcatgtagt 28980 agctaaagga ggttatttac aaggcacaaa ggagaaatac atagcccgtc tatactgcat 29040 cacttttttg ttctcttcac ttgtgcatag tatctactaa tgactagctg aggatagtaa 29100 tttacataac attgaaatgg aaaaattaaa ggaacacttt ttgcttcgtt tttcaaagtg 29160 gacttaccta agaagcacta ccatgctcct taaaaatgct ttcttggttc tccccactga 29220 tgtcgccaat ctgggggtgg ggctcagaaa tctatttttt gtttttttag agcaaggcag 29280 ggtcttgctc tataacccag gctggagtgc aatgttgcaa tcatgactta ctgcagcctt 29340 gaactcctgg cctcaagcaa tcctctcacc tcagcctccc aaagtgctgg gattacaggc 29400 acaggaatct atttttttta acaagcatga gagccattca taggccaaat ttatttattt 29460 atttatttat ttatttattt atttatttat ttgagatagg gtctcattct gttgcccagg 29520 ctggaatgta gtggtacaat cacagctcac tgcagcctcg acctcctggg ctcaagtgat 29580 cctccaacct cagtctccca agtaaccggg actacaggca tgcaccacca cacctggcta 29640 attttttatt ttttgtagag atgggatttc actatgttac ccaggttggt ctcaaactcc 29700 tgggcttgag cgatcctgcc acctttgcct cccaaagtgc tgggattaca agagtgagcc 29760 acctcagcca gcatgttttt tgtgggatct cattattttt aactgtctca tgcaatatct 29820 aataataaaa tgtacatgtc ttcttcattt tatttctata tagagcgtgt tttattaata 29880 catgttgtta caacatctaa ttgcaaatac atatgaaact ctatccaaac tcctacccaa 29940 tctcttggta gtggaaagta catcagtcac aggaatagaa cccagagtca aggtcctgaa 30000 gtttgggcct tggctggaga gcagagtaga ctcaggtcac aacaccagga tgggatacat 30060 ggaggagaag gaggaagatg gggggaaagg aagattctag gtctgccgaa aaagatcagg 30120 caggtaaaac tcagagacct tccagcaagg cccaaaacac cactagccac atgagaggtt 30180 tcaagcaatt gactcatctg cccctagtgg gatttttaaa ctacagactg gtataggagg 30240 tgacctgttt agatttactc tcaaacctgc tgtgttgggc cactccaatt tagactacac 30300 tttgctgaag ttctgaaatt caagaattgc ttctcacctc cttgtgacct atgaagagat 30360 gtcattatct gggtccaccc acattcactt gggagttcat tcaataaaac tttgcaatat 30420 aatgtaatgg gtgtcccata gggattcggg gcagaaatat ttttaactct cattttgttt 30480 caagtacaat agacagtaac taaattttcc agaaaacttt aaagatgctt ttatctctga 30540 aaggtttttc ttttttaacc cacttcagtc ccactgatgt tttcactagc ttgcctccag 30600 gataatgcat ttgatatcag tgaatgtgaa tacacacttc caaatgcttt gtgcaggctg 30660 atccactagc tctctttaga cttttgctaa tcagaaattg ctcaagaagg aaatttgtga 30720 gctgtttcca aattgcctac tgccttagac ttatgtaact atgacaggtt tattgatgca 30780 gctgggagca agtttttaat cttagaagaa aatgtttatt tctaaataga ggtgcatata 30840 cttttcataa aagtatttct agaggctttt taaaatgctt tgatggttta aactaataga 30900 aataataatc tttaaatatg cttatcagta gcatccccag aattcacgtc tttagtcttt 30960 gtacgaatta gatttcctgg ctaaacctgt gaaaaatctc atggtattag gaaatctgaa 31020 tgttgtttct ttgtattatt caggaattat atatttttaa tttttaaaaa gttaaataga 31080 tggagataat gttgcagtct gaaagggcag ccctgagaac ttataatcag tgctatggtg 31140 gctgtcctgc attctttggg gcagagcttc ctgagttagt ccccacagtt actacctctc 31200 cttcctcgcc tttcctctct tgctgctctc tccttcctat ctttactaat ttatcttccc 31260 atgtcaaccc cttaaattct gctgctcttt catagaaatc acctcgttgt cccgcttctc 31320 caccactcat attctagatt ggtagatatg gaccatacag atagtctacc atggctacca 31380 tcaaatattt ttgttcactt cattgtgcat agttacctac tagttattca ttgggagtag 31440 taatttgcaa attatttaaa aggaaaaatt aaaagaaaaa actttttgct gtagtttccc 31500 tttttttttt tttttttttt tttttttttt tt 31532 <210> 35 <211> 1390 <212> DNA <213> Homo sapiens <400> 35 ccaagatttc tcatccatgg tttcaactaa gaatatttta ttctctccag tgaaattttt 60 tacaattagg attgcaaaac tacatacatt caggtagatc tgtgcacatc attatctatt 120 tggaaaactg tctgtagaat tgtgccgtgt accatccatc cagccatacg cagcagccca 180 cagtcatgct gttctccatt catttataca ttctctacat catgttactt gcacacaaaa 240 gtccttacac atggctctaa gccattttta accccctgga aagtgtaatt ccttgacttg 300 gcaccctttc tcttaagaat tgatgtccct tgcaattctg atgaatacga gtctctacct 360 aattagacaa aaatcaattg cgatcaatac tcaagaaatg aaccccctac acaacactct 420 aaatttgctt tctgatccct agcaggaaca actgtctatt cattcatata ctcaatactt 480 tagaacatac tgggtacaag gaatcatact atatgctgga aataaaataa tcagtgatgc 540 tgtccttgat tttaaggaat ttaaaaccca agtatggaag ccaaacaagt aaattgacaa 600 tcataaaagt actataagaa gcataagtaa ggactgctat agaaatacac aagtgaactt 660 ttcaaggcat gcatgaaaga gaaaacattc tatagaagtt tcattcattt acttaataag 720 ttaatattca gccggatctg gtactaggtg ccatgttaac aagtctgtat tttatccaga 780 aggaaatgtg gaactattaa tcactgttaa gcttgcatgt ggcataatca gtttggtatt 840 caagaaaatt ctgaattact ccacaggtaa agttttattg ggataacaaa gggaaagaaa 900 aggagtaaaa agttattaga ggttactgat cataaggaat aggatgaaca aggaaagaaa 960 attcagtgac tgaaaagcaa ataaatagga acatagcaaa aattcaggac tggctaaaga 1020 acttgtatag tgtaaataac agagtgagaa aaatcgagag atcatgattc agaaatgttt 1080 taggattttt agatgtagag gaattttagg ggacagtaga tctagggtgt acccaaaagg 1140 gaagacagct gaaatgttag atagttgaga tgaagaccag tggaattgag gaggccataa 1200 acttggatgg gtactcccct tggaagctga gtttagccac ttcgatgttt ggactcaaag 1260 taaagtataa aaaagacagt agtcttatga gtttatcata gtggataaga cactatttca 1320 ggaggcagat tgcagcatac taattgtatg ctcttcggca agttacttag ctcttagatt 1380 ttcctctggg 1390 <210> 36 <211> 38342 <212> DNA <213> Homo sapiens <400> 36 cactgcagtc tctccctccc tggttcaagc aattctcttg cctcagtctc ctgagtagct 60 gggaccacag gcgctcacca ccacgcatgg ctcatttttg tatttttagt agagacgggg 120 tttcaccata ttggtcaggc tggtcttgaa ctcctgatct caggtgatcc acccgccccg 180 gcctcccaaa gtgctgggat tacagaggtg agacaccgcg cccagccata tttagattta 240 ttgtcgtttt cttttttgtt gttgttttct tgtttttttt ttttttttga gacagagtct 300 cactctgttg cccaggtggg agtgcagtgg cgtgatctcg gctcactgcg agctccgcct 360 cccaggttca cgccattctc ctgcctcagc ctcccgagta gctgggacta caggcgccca 420 cccccacgcc aggctagttt tttgtatttt tagtagagac ggggtttcac catgttagcc 480 aggatggtct cgatctcctg acctcgtgat ccgcccgcct cggccttcca aagtgctggg 540 attacaggca tgagtgacat cttacagata acgataagtg caggtggtaa gttgttaata 600 ccaaaggcaa ccatattctt tggacctaac gttttcttgt aggaataatt tgattcattt 660 taccgccaag gagcaagtgt tcaagaacct cctccctata agggcagaaa atttagatgt 720 cagtcttgct gaaatgcccc agtgccctcc ttctcacgca tccaagagtt tcctcatagc 780 ttggttgggt ccagatgggc ttggtcccat gtctacatat aattagggtg gagaggagtt 840 gaggcataca gcctggtgtc agcaagtcat gtcctgagcc tggagctgga caaagcccag 900 aactcaccta gtggccaagg gcattcagga gaggcagtga ctcctacgga agttggtctc 960 agcatttgtg ctgccatctc ttccggtcta actggccaga gacatttagg tgaagacctt 1020 tcacattgcc tttctctcag tcaaggaaga ggtcagctaa attggtccag gaactttgag 1080 tcaaactcct tcaattcctt gtcagctcag gggtgtagcg tggcagagag tcacggtggt 1140 aggtggataa ggagttggga gtgtttgggt cttctcagta gaaggggcta gggtaggggt 1200 tgcatctgcc tctggatttt gttgttgtgt tggtggtggt tttttatttg tttgttttat 1260 agagacaggc tcccactatg ttgcctaggc tggtctcaaa ctcctgggct caagagatcc 1320 tcccgccttg gcctcccaaa gtgctgggat tacaggcatg agccaccatg ccggcctgcc 1380 tctgaatttt gtgtcttctt tccctgctgt agcatttagg ctagaaccaa gcccttttgc 1440 agcagttctg gacacagtga ctgcctacaa ccgggcttgg ctgctgggac ctcactccct 1500 actaggccca agctcagagt gttctatctc ttagggacca actctttcat cataagtaca 1560 ttcaccccag gggcataacc caccccagga aataggactc aactctgtac caccgcagag 1620 aacaccgttc cttctggctt ctgagggaat gatacctcct gaacctgtgg gatgcagcag 1680 cgccgccagg accccggctt gggatgatct cccgctctga ttatcaccac cctgtggacc 1740 aagaccatcc cccacacccg ctgtccaggg atctactctc ctgggaactg agcaggtgtc 1800 ttcttaaacc ctgaaagccc aaagtgtctt gtgagtttgc cccttttctc cagacaatgt 1860 ggatccttga cctactcctg caagggaggg tcccctcttc cactcttacc aagaaggaga 1920 tgacacaaag tccatttctg gtagggtgct actttaaaag gcacccgtca cacacatgcc 1980 tcaagcccat ctgaaattat ccagggtgct ggcctttctc tacctatgca gctgccctcc 2040 tggaagcctg ggttgagaga gatgcgactc gttcagcagc ccgtctatgc tcagggtaag 2100 cccgagcacg tcagcgaagt ctccctggca tgggatccgg catccgggaa gctaagaggc 2160 atcagtgggg caagctggga tggttccaat ggcccatggc ctcctctcag ctttacccca 2220 cctcacccca accagagaga tcagtaggct ccttctgagg gtgcctcctt tctcaaaggc 2280 aggattcttc cctccagtgc aatggatcat gacctggctg gtccttcttt ctctctgatc 2340 ttggcctcaa tctaagtttc agtcaagtga atgacattat cccttaccta ctaggaatta 2400 aataggtttt aaagtacaca cagacacaca cacactttgg aatatttata tcaaaatgta 2460 tgttttttag gccaggtgtg gtggctcacg cctgtaatct cagcactttg ggatgccaag 2520 gtgggcagat tgcttgagcc caggcattca agaccaggtt gggcaacatg gtgaaaacct 2580 gtctctgcaa aaaatacaaa atttagcctg gcgtggtggc acacacttat agtcctagct 2640 acttgggagg ctgaggcagg aggatcactt gagccctgga ggttgaggct gcagtgaacc 2700 gtgatcgcag tactgtactc cagcctgggc aacagagtga gaccccatct caaaatatat 2760 atgtatatat ggttttttaa accaggtttc ttgagatcat ttcattggga atttagaaga 2820 aaaagaggca ttctgggcgt gatgtatgga gaattcttct ggagcgcttc atggaaccca 2880 gcctctgaag cagaagaaac aactgagttc caccaaggag ccctggtcac ttcacggtgt 2940 cttaacttct ccacatcttg gagtcactta acacttccag gacaccaaac agtctaacaa 3000 cttagttctc atgaaagaat gctgctgggt tgaattgaaa agcaggcaga gttagagaat 3060 gtgccttcta caaagtagcc atctcagaga gacttgtttg agtgaataga aaaatgaaac 3120 ctttagttaa agcaactgag tattgaacat acgcatgctt tagaactaaa aaataggccg 3180 ggcacagtgg ctcatgccta taattctagc actttgggag gccaaggctg gcagatcact 3240 tgagctcagg agttcgagac cagcctggcc acatggtgag gccctgtttc tactaaaagt 3300 acaaaaatta gctgggcgtg gtggtgcatg cctgtaatcc cagctactca ggaggctgag 3360 gcagaagaat cgcttgaacc ctggagctag aggttgcagt gagctgagat cgcgccatta 3420 cactccagcc tgttatccca gaactttggg agttatccca gaactttggg ggacagagca 3480 agattccgtt tcaaaaaaaa taattatgat tttaagactt gtgcttttta aaaaacaatt 3540 tggaataata ttgcaatgct tttttgtttg tttgtttgtt tgtttttgag atggagtttc 3600 gctcttgttg cccaggctgg agtgcaatgg cgcgatcttg gctcaccgca aactccgcct 3660 ccaggttcaa gtgattctcc tgcttcagcc tcctgagtaa ctgggattac aggcatgtgc 3720 caccatgccc gtctaatttt gtatttttag tagagacagg gtttctccat gttggtcaga 3780 ctggtctcaa actcctgacc tcaggtgatt tgcccacctc agcctcccaa agggctggga 3840 ttacaggcgt gagccactgc gcccggcctg caatccttat ttaattttaa ttttttgtgg 3900 agacaaggtc tcactatgtg gctcaggctg gtcttgaaat cctggggctc aagcgatccg 3960 cctgttttga cctcccaaag ttctagcata acatgtgtga gccaccacat ctggcctgca 4020 atgctttttt tggccaatta taagttagct atattaaatg agactaacag tgatgtttaa 4080 tgatactaaa taagacctgg ataatataaa ccacctttta tgtgatcatt aatatttttt 4140 atggtaggct gtaagtgtac agtgacagaa atgaggttca aaagccaagc aggtatgcct 4200 gggataagtt atagcctttt gttagcttta tgccactagc attcataagg cacatactat 4260 attcaaggac agcgctatgg tgtgagtgtt tgcatccctc caaaattcac atgttgaaat 4320 cttctttttt ttttcttttt ctttccttgt tttttttttt tttttttggc aggtaacctt 4380 ctgagctaga gtaggctcag agactccctc atctgttgaa atcgaatctc caatgttttg 4440 cctttaagag gtggggctgt tgggtcatga gggcagaacc ctcgtgaatg ggaataatcc 4500 cgccataaaa gaggcctgag ggagtttgct tgcccctttc ctccttccac catgtgagaa 4560 tgcagcaaga aggtgccctg tatgaagcag agggccctca ccaggcaccg aatccggtgg 4620 caccttgatg ttgaacttct cggccttcag aactgtgagc aataaaattc cgcacttttt 4680 ttctttttga gattgagtct cgctctgtca tccaggctgg agtgcagtgg tgcagtctcc 4740 gactcactgc aacctccgcc tcccaggttc aaactattct cctgcttcag cctccagatt 4800 agctgggatt gcaaactcca cctcccaggt tcaaactatt ctccagcttc agcctccaga 4860 gtagctggga ttacaggcac ctgccaccac acccagctaa tttctgtatt tttagtagag 4920 atggggtttc accatgttgg ccaggctgat cttgaactgc tgacctcaag tgatctgccc 4980 acctcaggct cccaaagtgc tgggattata ggggtgagcc accgcgcccg gccacattct 5040 gctttttata aattacccag tctaaggtat tttgttacag cagcccaaat ggactaagac 5100 agtgtattta gactggaggg catggggttt gggtttagat atttgaaatt gcagagagat 5160 gggctatgcc tcgcctttgt ctgcaggtct aggacaggtt ctgaggaatg tctgtagtgt 5220 caactggaca atgcaatatt caaacataac acagaaaatg gaattcctta actcttgctc 5280 tgcttctgtc ttctcaaaaa agaacatttt tcaaatcaaa aagaacaaat caaacctatg 5340 aggagatggt atgagaatat tttcatagta aagaaaatgg aaagaatttg tggaggtgat 5400 tgggaaatct tttggatgat ctctaggaat tatgaaaaat aaccgagcca cagagatggg 5460 aaatacgtaa ttctaatttt caaaaagaaa aagaaggtgg gttctatgac ctatagatca 5520 gtaagcttga gattgattct tggtgagagt gttgaagaga atgctagaag gtggtttctg 5580 agctcttaga aaccagcagg cagtgattat agtcagcccc atgtcactaa aagcaaattg 5640 tgttagcctg attccatctc cttttctgat aggattactc cactggcaaa cttagagata 5700 caagatggat atggtccctc tacacttcag aaaggaaact gacatagttg cttgggtgcc 5760 ctggggataa ggtacagagg cagagtatca ctcgcagctt ttaggtcaca aagaacagaa 5820 acaaattcta gtgagtttaa acagaaaagg gattttattc aaggatatag ggaagtttac 5880 cagctgtcca gaagggccag acaatcaggc tcagatatcc tacatctgat gtgatttatg 5940 gatttttgga tgcagagccg catccacaat cacagccctg gtctttggag ggcatgacag 6000 cttgtcaaca tcggcatgaa caccaaggtt tgccctgctg acacggctaa cactaaccct 6060 ggtgtcctga aaagggtata aagctgtccc catcctctgc caaaacagag tccttaaagt 6120 cccaacgttt ttgcctctcc agctcctgag tcaaagttca gcccaatgcc tctgtttggt 6180 ggagcccaga tcatatgccc acaccttagc tatggaggga gctgggaaag ccagatgctg 6240 acctgtttca cttctcatgg gaggaggtgg tctctgcctt ctgacagact cgcaaagtag 6300 ggaattctcc cacgcagaaa gtggggtcag atgatgagct gccgtaaaga atggctaatg 6360 ttgtcctcac aggggttgag ggatagggta attgtgctgg tttttaacgg gttgaaggat 6420 catagccaaa gcttgctaat taattgattc tttttaatcc agaggactgg ttttattgga 6480 ataccacaga actctgcatt atcgtgccac atgagggttt tttgttgttg ttgtgttttt 6540 ttgtttttgt ttttgtttta tcagtggctt ggccaaagac caaaaataaa cttgttgtat 6600 ttgcaggtga cacagagaat gagtggaata ctaatacatt gaagggcaaa atcaaaaccc 6660 cagaagatct ctaaaagtct gaatgaatca gcccatatta caagataaag tccataatgg 6720 taaacggaag gctctggtct tggtttacaa aatccaacca ctcaaatatg tagttgctgg 6780 taagaaaaaa agccataatt tcatgtggtt gccaagaaag ctcattaaat ccttggctgc 6840 attaatagat gtatggtatt tccaacaaag ccttctgcct cattctgcac tggagagacc 6900 acagctgagc cctgtgccaa gctatgtgca ccacagtttt caaagggctc gacgagttgg 6960 aggctgttca gaggggagca gcggggtggt agacactctc agccccttcg tagaggaaga 7020 atgataccac cgcaggagct cggccatgaa gaagggccat ggggggagtg atgacatagt 7080 ggtcaccaat tttctacaga gctttcacat ggaagatggg tacgatttat cccacggggt 7140 gtcaaggcat gaaattaggt acaattgatg taaattatag ggaatcttca gtctaagaaa 7200 gggtttccac tggagcaacc caaaagtgga tgagtctatg ttgggaggga gcaagttacc 7260 tccctgtcac tgaagacgtt cagattcgag actggatggc cagcatccag gggtgctgtc 7320 aaggggcctc aagctatgtt tagtctaaac gaactttcag ccttaagagt atattttttt 7380 taatgaaaac ataaggcatt acaaaggaga gatgagccag gtgtggtggc atatgcctat 7440 ggtctcagct actcgggagg tgaggtggga ggatcttttg agcctagaag atagaggttg 7500 cagtgagcca tgattgcacc actgcctggg tgacagagtg agaccctgtc tctaatgtta 7560 aaagaaaaac cacagagacg tttaacttaa cagagtttaa ttgagcaaaa aattatttgt 7620 gaatagggca gcccctggac cagaatgggt tcagagaagc tccagcttag gcacatggtg 7680 gaggaagatt tacggacaga aaaaggaaag ggatgtacag gaaacagaag cgaggcacag 7740 aaagagccag gctggttact gctggatgat tgccttgttt gttcatggtt tgaagaactg 7800 cccgcctttg gccggaactg ggtgattgac acaagagtag gcagccgtgt gtttacacac 7860 cctgtcaggt gacagtgcac tatgcatgag cacagcttta ggcagaatgt aaactataag 7920 gaggcagcat tgggctaaac ttaattttac actaaataaa gtctaaaaaa tttaaaagca 7980 tttttaaagg taatagaagt tagctgtgat gtgcatgtga acatttaaac tacatttttc 8040 gttttttttt taaaaaggaa gttttgtggc catggggatg ctgacaaaga ttgcttggga 8100 tgcacacaag gcagcggcga agcctgaggg gtgctgccag gccgggctct ccactggcca 8160 cggtaagaat cttcctgggc ctgtttgttt tggcctctgt gagcatgggc cacaatcacg 8220 gggaaatgaa ttgctaggaa gtcaattcct ctctgaagga aggactccaa agagagctga 8280 ggctgccgtg ttttctggcc gcccacacaa gccaacaagc tattccctgg gggcaaccac 8340 taatctctaa ccagacaacc ggtaatctct tattcattct ccgttgaatt cttgggctac 8400 actcaattta taatagaact taaagaatgt cctcatttta tctagagggt ttgtaatgcc 8460 tttatttcga ttcctcatga atcattatag tcatggatac ctgtgaacca cagcttcctt 8520 gtagagaggg gagaggggaa taagtgaaat tactccggag aaaacaaaca aggacgttta 8580 gctccagggc atgtggagag ccacagtctg agtctctcac tcgcatacca ggagataaat 8640 aattcagagg cctaacaaag ggaggcggag tagtcaaact ggttgaacac ctggtcggct 8700 gcacccagct aaacagggct ggtgtctgtg agggcttcct aatcattgtg gatgacattt 8760 aaagacaaca ctcatagcaa atattgcatt agaattttct gcttccaaga taccagtcag 8820 agtaagggtg ggagagaaat gagggaaaga acagataccc tactacttat cagattgcct 8880 tagagtacac atcatgaaag taattatgat tttctttttg agatggagtc ttgctctgtc 8940 tcccaggctg gagtgcaatg gcatgatctc agctcactgc aacctccatc tcccaggttc 9000 aagtgattct cctgcctcag cctcctgagt agctgggact acaggcaccc gccaccacgc 9060 ttgcctaatt tttgtatttt tagtagagaa ggggtttcat cacgttggcc aggctagtct 9120 caaactcctg acctcaggtg atccacccac ctcagcctcc caaagtgttg ggattaaagg 9180 tgtgagccac cacacctggc ctaattatga tttttaagat gacaacaggg ctatcaatgt 9240 tcatgtcttt gtgtcctcta taagagatca atgtatctct tgcctgaata cttccccaga 9300 ttagatttct ggaagctcaa agtagtgctg attgctgtct ggtcctggtc ttgcaatcac 9360 accccaccaa atgtaggcaa attgtcagtg tacaaggctg cctctgtggt gggaacattt 9420 tgggaacata aaagggaggc agggatttct cttttttttc gagacagagt ctcactttgt 9480 cacccaggcc ggagtgcagt ggcatgatct cagctcactg caacctccac ctcccgggtt 9540 cgagtgattc tcctgcctta gcctcctgag tagctgggac tataggcgcc caccaccacg 9600 cccagctaat ttttgtattt ttaatagaga cgggggtttc accatgttgg ccaggatggt 9660 cttgatctct tgacctcgtg atctgcccac tttggcctcc caaagtgttg ggattacagg 9720 catgagccac cgcacccggc ctgagggcag gtatttctaa tgtgtagtgg gtttcaagtt 9780 tacagtgaca tctcagagct gcaaaaatga aacattattt ctctataact gtactcaatt 9840 tacttatgaa gtagtggaaa actcttcatc ttggcacttt aggataactg acacccttct 9900 ggtttcaaag cttctttagg gtaattcctc agtcaatcca ggattttaat tccatcaggg 9960 ccacactccc tcatctcctc ctctggatga gccccaggtc tgtcccatgc ttcctgttct 10020 ccggcccccc ttggccttgg agacatcttg ttgccttggt ggtgcgtgtc agtcttggtc 10080 actgttgcct tcaccattga cccagtttgt cagctgctct taggcaacaa aaggagaggt 10140 ggctgttccc tgccggccag gccccgtcac tgcagtggca gtgctgctct ggccaaggct 10200 tcattctctg ccaccttcct caccctcacc aggcgctacg ggctcttccc ctgatttccc 10260 cacacaggaa ggaagtaggg gagactcagg tggggcggtt cttggaggcc cattttcagt 10320 ccaggtctgc cctgcctgcc tttccgctct gcttctctcc cctctcatgt tcttgtggtg 10380 ctggaagcaa gggttttaga gcaaacaagg gccacgtccc ttctgccctt acccctgtac 10440 tctctgtccc ctgccagtga aatgtcggct aaggaggcag agccaccgcc cccttgggaa 10500 caagcacacc tctgtctgta tctcttacaa ctcttctctc ctcccccatt tctgctcccc 10560 agttccctgg gtgctgagtc aggaaagcct ttatttcccc cccctccccc agtaagcttt 10620 tgcagtgcca ggaaagctat ttttttaatg cttattaaaa aaattttttt ttcgagacag 10680 agtctcattc tgtcgcacag gctggagtgc agtgacgcaa tctcggctca ctgcaacctc 10740 catctcccag gttcacgcca ttctcctgcc tcagccttct gagtagctgg gactacaggc 10800 gcccgccacc acgcccggct aatttttttt tgtattttta gtagagacgg ggttttacca 10860 tgttagccag gatggtttcg atctcctgac ctcatgatcc tcccacctcg gcctcccaaa 10920 gtgctgggat tacaggcgtg agccaccgtg cccggccccg gctaattttt ttgtattttt 10980 cgtagagacg gggtttcact gtgttagaca ggatggtctc aatctcctga cctcgtgatc 11040 cgcctacctt ggcctcccaa agtgctggga ttacaggcat gagccactgc gcccggccaa 11100 aaaatttttt ttgtttaagg aatagggtct tgctatgctc aggctggcct cgatctcctg 11160 ggctcaagca atcctcctgc ctcagcctcc taagtagctg gcaatacaga tgtgtgccac 11220 catgcctggg cagcaatttg tattgctttc ttttatggtg gagaaatgac cttgtgccat 11280 gagctgcatc ctttagagca gggtgtccaa tcttttggct ttcctgggcc acattggaag 11340 aagaatcgtc ttgggccaca tataaaatat gctaacacta atgatagcta atgagctaaa 11400 aaaaaaaaaa attcaaaaag tctcataatg ttttaagaaa gtttatgaat ttgtgttggg 11460 ctgcattcaa agccatcctg gccacagatt ggacaagttg ctttatcgta acacctataa 11520 atgctatgct ctgtccccca agcttttact atcatcttgc ttatttatgc ctagtgttcc 11580 attattggaa cggtaagcat gtgggagtta tttatatcct actgctcaag gcatttccaa 11640 ggtctgattt ttcaaattaa aaaaattgcc acctcagcca taaatgggtt aaaactaagc 11700 cattttgaaa ttcagaacaa aactgcctct ctctcacatg actagctctt tcaagcgact 11760 gtggcttcag atattgtgaa ttatccatcc gctcagcacc tcctggctgc tttgttctcg 11820 ctgttttcac tttctcctga agtaatgaat gccattgagc caatgggggc agagtcaata 11880 actttgaaga aaaagaacct cagtttaaaa tttcaaaata ttatttttaa tttttgataa 11940 cttatatgcc ttcactccaa ataaatgaag atcaaaatat gtgaataaaa ttcaagatga 12000 caggccgggt gtgatggctc acatctgtaa tcccagcact ttgggaggct gaggcaggca 12060 gatcatgagg tcaggagttc gagactagcc tggccaacat agtaaaaccc catttctact 12120 aaaaatacaa aaattagcca gagtgatggc acatgcctgt agtcccagct actcaggagg 12180 ctgaggtggg agaatcgctt gaactcggga ggcagaggtt gcagtgagcc gagaccatgc 12240 cattgcactc cagcctgggt gacaaaaaaa aaaaaatcaa gatgacatca ctctagtttg 12300 tcccaatcct ggtgtagctt gagtaaggaa aagcagatgc cctcgttata ggtctaagtc 12360 tcgcaccaag gttgctcatg tttctgtttt taaaccttcc acaaagaaaa tcacatgtag 12420 gtcacactgt cctcactaat atctggtgga gcctcatatc atctggattc ctgttttcac 12480 ctataagaac tgatagtttt gtttgtttgt ttttgttttt gagacggggt cttgctctgt 12540 tgcctaggca ggagaagtgc agtggtgtga tcatagttta ctgcagcctt gacctcctgg 12600 gctcaggcga acctcccacc tcagcatctt gagtagctgg gactacaggc atgcgccatc 12660 atgcccagct aattttttgt attttcagta gagacagggt tttgccatgt tgcccagcct 12720 ggtcttgagc cccagggctc aagggatcca cccacctcag cctcctaaag tgcggggatt 12780 acaggcatga gccacctcat ctggcagaac tacttttttt ttttttttga gatgaagttt 12840 tgctcttgtc gcccaggctg gagtgcggtg gcacgatctc agttcattgc aacctccgcc 12900 tcccaggttc aagtgattct cctgtctcag cctctcgagt aactaggatt acaggtgtgc 12960 accaccacgc gcctggctaa tttttgtatt tttagtagag acggggtttt tgccattttg 13020 gccaggctgc tctcaaactc ctgacctcag atgatctgca agcctcggcc tcccaaagtg 13080 ctgggattac cgtgagccac tgtgcctggc ccagtggaaa tgatttttaa tgaggcagag 13140 ggagcagcgt ttgattcaca cacatttagt gtatactgtt ttcaacagtt taccacatgc 13200 tgcagggggc agaggtggat ccaggttttg ggaggcctga agcttacaga atctgggcgc 13260 cctttttaag tagaagaata caaagttatg tagataaata gttatcacat aatgagcaaa 13320 gaatgtacag caaatcacat tatcaaaagc taacaaatca cacaaaatca taaaactcca 13380 aaaagtacat aatattttat taaccacttg ctatactttt tttttttttt tttttttttg 13440 agacagagtc tcactctgtt gcccaggctg gagtgcagtg gctcgatctc ggctcactgc 13500 aacctctgcc tcccaggttc aagagatact ccagcctcag cctcctgtag ctgggattac 13560 aggcatgagc cactgcgcct ggcccacttg ctatacttct atcgtactcc cctacccctt 13620 gtattttttg gctgtgtatt cttaggtgac cttttgagag aaaacaattt tataatttca 13680 ttttctctaa agagaataga atcattcagt ttttcttcta gcatggtgga ttgcaatgta 13740 cttatacata gtttgaaagt tttgtttggt aatgtcattt aaaactttct tttttttttc 13800 tttttttttt tgagaccgag tctcactcta ttgcccaggc tggagtgcag tggtatgatc 13860 tcggctcact gcaccctccg cctcctgggt tccagtgatt ctcctgcgtt agcctcccaa 13920 gtagctggga taatatatgt gtgccacaac acccggctac tttttgtact tttagtagag 13980 ataggcgttt caccatgttg gccaagctgg tctcgaactc ctgagctcag gtgattgccc 14040 acctcagcct cccaaagtgc tgggattaca ggtgtgaacc actgcgcctg gcctgtcatt 14100 taaaattcta tccaaggttg ttgttaaatt tggtataacc tctatcaagt tctcttgata 14160 tacatacaag ctataaaatt ggaaagaata ttcccccaga ctggcttctg gctccaaact 14220 gtgttttatg ttcatgagac acatacttgt ggtgccagaa gccacagcac acatttatat 14280 catgatgcaa attttggcct gcaccttcat gtcctgatgc ccagtgagtt ggcacaggga 14340 gagggcgttt tcctggaagc cattcctaca tcaggatgag tagcaataac ttcaactatg 14400 cacagacaca tctgcaaatc agatgactgt gttttaccaa gtccaactaa atgtacccct 14460 aactcaactt gccgttagcc aattccccaa aatgctcaca gccacttcta ggacccctaa 14520 cacaagtggc gttggagcag aatgcaaatg atcttaatcc cctaaaattg cagtttctta 14580 cttatagaaa ttttatatat aaacacacac acacacggct aagggtcctt gtagggcctt 14640 ggaaggagcc cgtgcaaatg agggattctg aagcttcaac cccattagct tcactgcaca 14700 gccatagctg atggggtggg aggatggatg ctgagcaaag ccagaaatca ggttcttgct 14760 gagaagacca acacaaaaga ccacgatgcc acagtccgca gtccagtgac ttgctgactg 14820 tgtcactctg aaggagagat acgggtggga taaataaagc cctgagtggc agctcagaag 14880 gagccagggg ggattttctg caggccccgg tacccacagt tacatcgccc tcttggtaca 14940 gcctcatcat gatgagtttc aagagagaat tcaacaacgg ctctcctccc ttaactgttt 15000 ggatgctaaa gtgttgtgat ttttgttatt actgtttcta attcagatgg ctgatcaaac 15060 tcggtgtttt ctgatgcatc tgtgaacaaa gattacactt agataatgtc taaaatgcaa 15120 tgccagctga gtgcagtgac tcacgcctgt aatctcagca cttagggagg ccaaggcagg 15180 aggattgctt gagccaagga atttgagacc agcctgagcc atattgtgag gccccatctc 15240 cacaaaaaaa tttaaaaatt agcctgcagt cccagctatt tgggaggcag aggtgggagg 15300 atcctttgag cccaggaggt caagactgca gtgagccatg atcatgccac tgcactccag 15360 cctgggtgat agagtgagat cctgtctcaa aaaaataata aaataataaa acaaaataaa 15420 ataaaataaa atgcagtgac acttctaccc tcatatgctg gagtttgatg ggggagcaca 15480 ttgatttaga tgccgcaaaa gcagcattta gctgtggaat tacagtcgtt acccatttgg 15540 gtatatttta ctctgcctgg aagagttcat gtgtttcacg gttgctacta ggtaaggacg 15600 caggccctgg gagatcctgg ttcaacagtg actgtcttat gtaacagagt cattctcttt 15660 atgaccacct taggaaccgc taaggaacat aataagaaat acacagaact gattgtggaa 15720 ctgctctttc tccctgcgat tcagagggga aaagataaag ccacacagcc ctggggcctc 15780 ttgcttaaga acacatctca gtttaaccac caaggccgtt atgataacaa atgtcagtat 15840 ggaggtgtga acatcagggg ctattcaagg acgcttctct gatcactgcc atgtctatct 15900 gctgtgatca cgactatttt ataaacaccc ttcctaccca atgccatcag aattttaggg 15960 acgatgcttc agtaattatc tttttttccc tccttcctcc ctattttctt tttcctctga 16020 atagctgcca aagtaactag agtcatataa ttttagagct ggaagctcag ggagaggctt 16080 ggatcctgat gacccaagca tgggaggggc ctgaaaaaat gtcaacagcg ctccgttgtt 16140 gatcccacac atttacttaa tatgagctgg tgctggcaga ggtttatgtt ggaaaggctg 16200 caactttctg tgccccacat aaatgagata aaacctgggg aaaggagtgt tggtttaaat 16260 cagaaaggct ctggttttta tttgatacta aacaaatcat gcagtttaca agtctgtgac 16320 actctaagag ttaactagca gttttgtttt ttttcttttt tttgagacgg agtttcactc 16380 ttgttgccta gtctagagtg caatggcgca atctcggctc accgcaacct ctgcctccca 16440 ggttcaagca attctcctac ctcagcctcc cgactagctg ggattacagg catgcgccac 16500 catgcgcagc tgatttttgt atttttaata gagacagggt ttctccatat tggtcaggct 16560 ggtctcgaac tcccgacctc aggtgatccg cctgcctcgg cctcccaaag tgctgggatt 16620 acaggcgtga gccactgtgc ccggcctaat cagcagtttt taacatgcta cacagggtct 16680 gggaaagaca gctgccaagt tgggggcttt gaaaatatga gacatctgta aataataacc 16740 tttgggtatt tcacctgtgt ttgcttcttt atattacttt tgtgtgtgtg tgtgtgtgtt 16800 ttgagacaga gtgtcttgtc acccaggctg gggtgcagtg gcgtgatctc ggctcactgc 16860 aacctccacc tcctgggttc aagcaattct cctgcctcag cctccctcag gcacttgcca 16920 caatgcatgg ctaatttttg tatttttagt agagacggag ttttgccatg ttggccaggc 16980 tggtcttgaa ctcctgacct caggtgatcc acccgcctcg gcttcccaaa gtgctgggat 17040 tataggcgtg agccaccatg cctggcatat attactttgt tctaaaatta atttagatct 17100 ggcatcctct ttttgtccct caaatgttat tttaccaaaa catatattat tgggacaaga 17160 ggcaaattgc atggccaagt tgaatgacgt tattccccac tctgacagct tttgttttta 17220 actctagaat ttgtacatat ggctttggaa acctcatcca acactaagta atgaacatac 17280 atgaggatac tatgtatttt tcaacctgca agcccaagat ttcaaattct ttggtttatc 17340 gcagagaaca catctctcaa attgtcttca aggagcactg caggaggtac aatccattcc 17400 ccactaaccc aggaagactg tctgaatttt ttcagaggga agatgggtgg gggagaagtg 17460 gggatggtta atgggtacaa aaaaaaaaaa tagaaagaat gaataagacc taatatttga 17520 tagcacaaca gggtgactat agtcaataat aatttaactg cacttttaaa aataatgaaa 17580 agagtataac tggattgttt ataacataaa aaataaatac ttaaggggac agatacctcg 17640 ttttccatga ggtgattatt atgcattgca tacctgtatc cagagtatct catgcaaccc 17700 ataaatatat acacctacta tgtacccaca aaaattaaac attaaaaagt taatcttttt 17760 aatgtttaat tttttttttt gagacaggcg tggtcttggc tcactgcaac ctctgcctcc 17820 tgggttcaag caatcctagt gcctcagcct ccggaatagc tgggattaca ggcctgtggc 17880 accacgccca gctaatttct gtatttttag tggagacagg gttttgctat gttggccagg 17940 ctgaactcct gacctcaggt gatctgcctg ccttggcctc ccaaagtgct gagattacag 18000 gcatgaggca ctgtgcctgg acagaaagtt tttaaaaaaa atttgttcag agggaaccca 18060 tttcctcttc tgctacacag acagccaggc ctgacttgca ctgtttctat ccccccacaa 18120 aaaaagcaac aacatcaccg agaagatagt tctgtttgtc ttgatgatca acatagatct 18180 gtatagttga ttttgtgcca gcaacaggct ccagtcacaa caacatgaga ttccaggcct 18240 ttttgcctgc catgctggac acagactggg ccatagagaa taggagaacc cgtgtgttct 18300 tctgagttgt ctgtgaagaa aaatacacgg ggagaggggt agacgtgagt tcctggaaga 18360 gtggagatgt gtggggaatt ctccagcgtt ccttaattag aaacacgact cagtgatgtt 18420 ctttggagcc caagacccca ggaggcactg agtccagtgg tcccaggaag ctaaaaatga 18480 gggcaagagt cagcgtggct ttaaaaatct ctgatcactc atcccccaga atgaaatctg 18540 ggactcaaaa gctctgatgg aaatgaagca gactttagga ggtctggttt cgggggtgct 18600 ccaggagctg aatgtgaaat gttatttgtt ccagaaagtc ctggcaactt ggcgcagcga 18660 atttgatcag caccatacgt acgacctgtc tcaggaacgg tgccatgtgt gtgactagga 18720 ctgcaaagca gcttgtgttc gtgggggaaa tgacaggcac aggaaggaaa agctgagaac 18780 actgaaacgg ttcctaatcg tgcagtgggg aaaggagggc gactgccgcg cagagtggca 18840 cgttggctgg aagaggggat tgatcagcag tgctggcagg aacagcatag gcttgtcgtg 18900 tgatctaaca gaagaggcag caatctggag gcgccccaga tcagagaaga gacatcaagc 18960 cccaggagaa atggatttcc tttctcccca cccatcagct gggtaggaag cccgaaggag 19020 cctttcatgg aactatggga agggctcctc tgacgcagag gggatgaact ggaagcaaga 19080 tgctgactgt ttccaaaggc ttgacagtca gaagcaggca ggcttcagcc tattgagata 19140 ctttacccaa gaggatttcc gcttaggttc tgtcttgaaa gaaatattcg ctcccaaatt 19200 tcctcccatc aagagtgctt ctccctacag aaggctaagg ctcacaggtt gtccccaggg 19260 acacatttct ttcaagtagg atgactggta tgtttagact gaaaagctga tttactggaa 19320 gattgctatc accccctggc ctaccatgtc gttggtgtgg ccagtgttta tcagacagtg 19380 gtgtttccag cttaggcctg aatggaagaa gaaactgaaa gaagaaataa aaagagagat 19440 gcgccgggca tggtggctca tgcctgtaat cccagtgctt tgggaggccg aggtggcaga 19500 ccacttgagg tcaggagttc aagaccagcc tggccaacat ggtgaaaccc cgtccctact 19560 aaaaatacaa aaaattagct gggtgtggtg gcgtgtgcct gtggtcccag ctactccgga 19620 ggctgaggca ggagaattgc ttgaacccgg gaggcggagg ttgcagtgag ccaagattgt 19680 accactgcac tccagcctgg gcaacagagt gatactctct caaacaagac aaaacaaaca 19740 aaaaagagga ggctcggcac ggtggctcac gcctgtaatc ccaccacttt ggtaggctga 19800 ggctggcata tcacttgagg ttgggagttc gagaccagcc tgaccaatat ggagaaaccc 19860 catctctact aaaaatgcaa aatcagccag gtgtggtggc gcatgcctgt aatcccagct 19920 actcagaagg ttgaggcagg agaatcgctt gaacccggga ggcagaggtt gcggtgagcc 19980 aagatcacgc cattttactc cagcctaggc aacaagagca aaactccatc tcaaaaaaaa 20040 aaaaaaaaaa atggagagag agatgtttct cagctttggg aaatgctgac ttttccagca 20100 cacctttgct cagaaaagcc ctatgatata aagtgtcata ggaaccttgt ccttggaacc 20160 aagcctagcc taggctcagg gacatcatgt gggagtgaca taaaggaggc tcctctgtca 20220 ctgtgcttgg gttacaagta attctcgaca tgggagcatg ttgatttcta accatcggtg 20280 gcggagctgt gacttcccaa gctggtggct gacctcaaga ggactattat agacactgtg 20340 ggaccacggc ctgagaaaag aatggctacc tccctctcta tcccatgacc tctaacggcc 20400 cggtcaccac catggccttt tgttcctgga gagggacagg aactttggaa agtggggtcg 20460 ctctattgct tctgcaggtc atcttcccag acttgcctaa gcctcagaat ctcagtcttc 20520 tgctctgttt tgcacgtctt ttttgaaagg tttttaaaaa ttacaatcta ctgtacagaa 20580 gaaaataata cacagaaaat aattttagaa aataatacaa cagatatcta agtatccacc 20640 acccagattg gacaacatat taacattttg ccccatctat atcagatatt atttattttc 20700 ttttttactt atttttgaga cagaatctcg ctctgtcgcc caggctggag cgcagtggtg 20760 tgatctcagc tcactgcaac ctctgcctcc caggttcaag cgattctcct gcctcagcct 20820 cccgagtagc tgggactagt ggtgtgcacc accatgccca gctaactttt gtatttttag 20880 tagagacagg gtttcaccat gttggccagg atggtctcga tctcttgatc tcgtgatccg 20940 cccgcctcag ccttctacag tgctgggatt acaggcatga gccacctcgc ccagcctatt 21000 tttatttttt ttaagacatg gtcttgctct gtcacccagg ctggagtgca gtggcacgat 21060 cttggttcac tgtggccttg accttccagg tgcaagcaat cctcccatct cagcctcctg 21120 tgtagctggg actacaggag catactgcca cacttggctg attaaaacat tttttctttc 21180 tgcagagaca gggtcttacc atgttgccta ggctggtctt gaactcctgg gctcaagtga 21240 ttcccctgcc tccggctccc aaagtaatgg gattacaggc atgagccagc atgcccagcc 21300 tatatcagat ttttttaaaa ttgcagatag aattaaaaac ttgcttatct atttttagta 21360 gagggaaaaa cctaaataag tttaattcta gtaagttgct gactctacac aacaacttcc 21420 tttcagtctt cagataatgg aaactttgtg gatttatgca cagcacccaa accccagaga 21480 tctgccccaa cagaaagatt gccaacaaaa tgtttgtctt aatacttgaa caaatttttc 21540 tcaaacttac attgtatatt tttctccacc agtttgctaa atgtccacaa ggttaatacc 21600 cgcccagcca aatgaaaaga ccactgggat caggtgcggt ggctcacacc tgttatctgt 21660 tccagctact tggggaggct gaggtgggag gatcgctgta gcctgggaaa tcgaggccgc 21720 agtgagctat gatcaagcca ctgcactcca gcctggccaa cagcgcaaga gcctgctcta 21780 aaaaatcaaa ataaaaaaaa aaagagcatt gggtctccaa aggtaacagg tgtgaaatac 21840 accttagcct actcagaatt ttgccccatg aaataagtaa ggattattaa atatttctgg 21900 aaactcaaac aactctttaa acaatgttca caatttttca atgtccacat cagccaaacc 21960 cacggaaagc taagcattaa ttcacctact gttggagagg ctagactatt taaggaatct 22020 ctcctgaatt ctagtcctga atttccaatg caactcgtgt ccactagaat gttctgtgaa 22080 tgtttcaagc ttgaaacgcc tgcagccaaa cttgttttct ttccatccaa ttatatcctc 22140 tttccaatgt tccccttttt tcattaaagg caccactatt cttccagcca tcctgattca 22200 cagcctcaga gctggcctca atttccttgt ctccttcgtc ttccacatcc aattattcac 22260 taaatcctgt tgaatttttc tcaaaatatt tcttgcacct gtttactcca ttctgctccc 22320 actgccacct ttctaatgaa gtattttcca cctgtgtgtt tcggctcctg cagcagattc 22380 tgcatctccc ctttctcctt tcaatgaatt atcagtatca gattaatctg ctgaaagaag 22440 cactgtgtgc catcctgctc aacataattc agtgattccc agatggctta ccaaataaca 22500 gcttttaaaa aaatccagaa ccttcagtga tcttcacgat ctttatatgt ccaccttcct 22560 agacacatcc cacattagga acccattgaa acctctgccc caggcgcatg gcactactgg 22620 cttgctaatt ctgattcctg ttcaagtatt tctttggcct aagtattcct tcccctcctt 22680 cactacatga accaatcttc atggtgctta atatgaacca gatcatctgg tgggcctcta 22740 atacaacagt gaacaagaca gaaacaaccc ctgcctccat atactcctta cagcctagtg 22800 gagaaaacaa aagatgaact ggcagttggc atgccaggct gtgcaggaag aactgtgaca 22860 aggaaagaca aggctgaggt gggcggatca cttgaggtca ggagctcaag accagcctgg 22920 ccaacatggt gaaaccctgt ctctacaaac aaaaaaaaaa attagctggt gtggtggtgg 22980 gcgcctgtag tcacagctac tcagtaggct gaggtgggag aatctcttga acccaggagg 23040 tggagattgc agtgagctga gattgtgcca ttgcactcca gcctaggtga cagaatgaga 23100 cgctgtctca aaaaaaaaaa aaaaaaaggc caggacccca gagccaggca tggggattca 23160 gagcaggctt ttcagaggaa gggataccca accaagtttt gatctgttct tcatgatggc 23220 tagtgaggtg aaggagaggg agaagggtca gaaaagaact ctacagcaga gagaatcatc 23280 ctgctcagcc cctatccaac ctttaatgcc cacctcaaat gccttccttt tttttttttt 23340 ttttttttga gatggagtct cgctctgtca cccaggctgg agtacagtgg caccatcttg 23400 gctcactgca acctctgcct cctgggttca agtgattctc ctgcctcagc ctcccgagta 23460 gctgggatta caggtgccta ccaccatgcc cggctaattt ttgtattttt tagcacagac 23520 agggtttcac catattggcc aggcttgtct tgaactcctg acctcaggtg atccggctgc 23580 cttagcctcc caaagtattg ggattacagg catgagccac tgcgcccagc ctcaaatgcc 23640 ttcttgacca ggccggtggt gtactgtgag aacacagact taaagtcatc cagaaacaaa 23700 tcctaaccct gcctctgctg catgctagtt gtgtacatga ccacgcaaaa tttgctcatt 23760 ctcaatatga gtcaatctct gaatctgtaa aaatactctt tcttttgaca gggtctccct 23820 cggttgctca ggctggtgtg cagtggcatg atcacaactc actgcagcct cgacttcctg 23880 ggcccaagct atccttccac ctcagcctcc tgagtagcta ggactacagg cgtgcaccac 23940 tataaccacc taactaaaag acaatttttt tgtaagggtg gggtctcact atgttgccca 24000 ggctggtctc aaacctctgg gctcaagcga tcttcctacc tcagcctccc aaagtgctgg 24060 gattacaggc atgagccact gtgcccagca gaaatactct tacattacag agtttattca 24120 ttaaataaat attaagcaca agaaccacat actcttctcc gtgataagga tacacttaag 24180 aataggatag aaatcttggc tcttatggtg cttacattct agtaaggaaa aggtgacagt 24240 aaataagata aatatgtaca ttatggagta tattggaggg tgatggattc tatggggaaa 24300 atacgtcaga gaagagagag agtagggggg aattgcaact ttattcattt gtttattatt 24360 taactcattt attcaaacaa atagtattga aggtctgcta catgccacac cctgttctag 24420 gccctgggtg tatagcaggg aacaatggac aataaccttt gcctttatgg agcttacatt 24480 ctgatcagaa agagagataa gcaaaataaa aatagaaaaa tatggagatg tagccgggcg 24540 cagtggctta cgcctgtaat cccagcactt tgggaggccg aggcaggcgg atcacctgag 24600 gtcaggagtt tgagaccagc ctggccaaca tggtgaaacc ccatctctac taaaaataca 24660 aaaattagtc aggtgtggtg gcacatgcgt ataatcccag ctactcggga ggctgaggca 24720 ggagaatcac ttgaacccag caggtggaga ttgcagtggg ctgagattgt gccattgcac 24780 tccagcctgg gcaacagagc gagactccat ctcaaaaaaa aaaaaaaaag ccaggtgtgg 24840 tggctcacat ctgtaatccc agcactttgg gaggctgagg tgggtggatc acgaggtcag 24900 gagttcaaga tcagcctggt caacgtggtg aaccctgtct ctactaaaaa tacaaaaatt 24960 agctggacgt ggtggcacgc acctgtagtt ccagctactc aggaggccga ggcaggagaa 25020 ttgtttgaac ctgggaggcg gaggttgcag tgagccaaga aggcaccatt gcactccatc 25080 ctgggtgaca agggtgaaac tccgtctcaa aaaaaaaaaa aagaaaagaa aaaaacatat 25140 ggagatgtta gtgcaaaata gaaagatgga taggaaaaat agtagatgag ttccaacatt 25200 caacagggag gccagctaac ccgactgaga aagcagtagt tatgaaaagg tgtggcggga 25260 tctaggccag ccgtgtgaac aaatggagga agagaattcc aggaacagca agtgcaaaga 25320 tgccacattg ggactgcatg gtgtgggcag gaggagcaag tgaggggaga gcagaaagag 25380 gcaaacaggg gagagcaagg caggtcaggg ccctgtgggt tattgtaagg actttggctt 25440 ttactcggag tgacaaggaa acctagtttg gagcagagga gttacccgat cagatttgta 25500 ttttaacatg gtggcgctgg gtcaagaata gtcaagaaga gggaccaggg cagacgctgg 25560 cagggcagct gggagaccac cgcaatcacc cagacaaggg gtaaggaggg tgtggacaag 25620 cgtgatggca acagaagacg ggcagatggc agggttctgg atgtatctta aaagcagggc 25680 taacaggact tgtgatcaga tacgggatgc agaagaacta aattgattcc atttttggct 25740 tgagcaactg ggagaatgaa atagctcttt actgaggcag ggaagactct gggaggaaaa 25800 ggttgggggg aactatcagg agtccagctt ttgatgcgtt gagtttgctt tagggtgatc 25860 ctgcaaagtt tcactgcaaa ggggatagtt cagtaaagac ttgaaggaaa tgaggagcag 25920 aacttgggaa gattaaatga aagggtgttt gagagggcac ttcgcatagt gcagtgccgg 25980 ccagctcagg ctccgttaat tccattccct catccataac aaacttcttc cgctccaggg 26040 ggcaggggct gggaagcatc agttcattat tggaaaatcc tcgctctagt gggtaggctg 26100 caccttgtgc attgtagttg ccaaactcta tttgctgaat tcacgagaga aaggaataag 26160 ctataatcag taaaggaaac tgttccaacc agcttccctt tctccttccc ttccaaagaa 26220 gaggtttgag ccaagatgct cttgtgtccg ggtgagggga attagaggtc tgaatcctct 26280 gtcttatggt gaacacagcg tgggggttct ctgagtgtag aaccacctgc agcccaatga 26340 gcagggatag tggtaaaata tgaattcttg gaccctttcc cagaccttct cattttgagt 26400 tgttagggga gaaacgggta tctttctgtt acagacacat gcagtgcttc cttggaaact 26460 aaagtttaag aactactgac actagggaag atgacccttc attgacattg ctcctcggag 26520 gcagatcatt tccagccatg atgtggtaaa ttacagccgc tctgcaattt tatgaataat 26580 gtgtgctcat cacctaatca aacctctcca gtggaggtag aacctggctg gctcagatcc 26640 ccactcacat tgtcaggtga ttgctttagc aaaaggcctt ctgccaaata cctcttggtt 26700 gaactttgca gcttgaggag agaagtatgc acgaacacat aaatgccaaa tctcttatta 26760 ttctgagttt tcaaacaatg aatacgattc caccccacat tcttgagaaa gggcagcaca 26820 cctatctcac cctcagctgt gatgaagcaa gaaactcagt ttcttcacat tgctcggtga 26880 gtctatacca caaacaggac taaaagtcac atgttggctt tgggcaccat tttatcgtga 26940 gcctttcata gcccatcttc caaggctatt aaaatatcag ctccatgagg gcaacattcg 27000 tgttgtttat tgctctcttc ccagtgccta gaagagtgtg tggcacacag tagtcattca 27060 gtaaacggca gaatgaatcc attccacttc ctaaagtgaa gagccaaatc gacacacatt 27120 cccatctgtg gagtatcaca gtttcctgca gtttacttcc acatacctca ctccaccagt 27180 taactacccc ctatataaat ctgtgcagtt ttcacttaag atataacttt ctggtgaccc 27240 cataaaaaat tggcagaaat tctcagaaag gatgataatg taattggtct tgtggggaat 27300 ccatggaggg atatatttca cattattcat gtttccagat gggcttcagt ccccagtgca 27360 gtcattccag aaccctttct cagcgttaag tttactccga aaaatataaa tagtgattta 27420 gggcttgatt gctcccacaa aaggcacccc tgttttggtg cagggtggga aggggggcag 27480 aggaagaggc agctgggaag ctgagtgagg ggccaggcgc ccgctgggtg tgagccagca 27540 gctggtcaga gtatctctgg aggatgaggg tttcgcaggt gggggctggg gactagctag 27600 agatgggatt gtccgtggtc aggcagttca ggaagctttc agcagcaata aagcttggat 27660 gtgggcatgc caagcttgga ggagatatgg gtccattccc atccttctga aaaaacagtc 27720 ttcaaacacc acggctagtg tccaaggcta cttagctcag ctggttgggg tgctgggcta 27780 ctaaaatttc actgtagcat ttcctgaatt cttactaggc tcatatatta acaccttcaa 27840 caaatatttg tgtgtcagcc tctatgctga gggctgggga tacagctatg aacaaggctg 27900 tgaactaagt actgtttctt taccagtgaa ttcttccatt tcatgggcct ctgattctgg 27960 ccctagtcag atatttctca aatgcctgac gttgtttcca aaggggtaca ttcggagtag 28020 ctagatcaca gcaaacgctt caagagttct caacaatagg tcagtggaac cttgatattc 28080 taaggacata atgatctaat ttagactgaa aatcatctag ccaaacacac actaggcatt 28140 taattcatgt aaggctcaat cagaatgtca gtatgaacca gataggacag agtgttcatt 28200 tgcagagaac aatatcccgg cttgcctggg cggctgcaaa gcctttaaac tgaaatcctt 28260 gcttccactc ttgctctgca cagcagccaa agaattttat caaccctcca ccggcttcct 28320 gttgcaattc gaataaaatt ccatctcctt accaggatct acgcagccct ggagtctggc 28380 ccctggttgt atctctggaa gctggtcctg gccttggagt tgacctgaaa ctctttcccg 28440 cctcatcttt tctcgcctgg ctcctcatta tgcagagctt tgttcaaata caaagctctc 28500 cttcccaggg aggtccttcc tggccagtct ttctgtagca gttctggacc ttccccacgg 28560 catctcttta tgtccttagc gtatttctta ttcttcatag tgggaatatt atagcaattt 28620 atagcaataa atgtttgttg agtgaattaa tatgcatcac acttactaaa cacccaaagg 28680 ttttctgggg atgtctatga ctattaccag atggccaatg gtttgcggca ctttattttt 28740 atattttttt acagcccacc cataggagat gacagtactt tattttattt tatttttatt 28800 ttaagagaca gggtctcact gtgttatcca ggctagtctc gaactcctgg gctcaagcag 28860 tcttacctca gctgcccaaa gtgtcaccag gctggagtgc agtggcacga tctcggctca 28920 ctgcaacctc agtgaggtgt gagccaccac ttttaaaacg ggcctgacag cactttttaa 28980 aatcatattt gaaaacctgg tacttgacac agagccctag aacctactat taacaaagtg 29040 cttaatattg ttgttgttgt tgttaaattg attctaacta aattaacacc agaccagtga 29100 ctggaaaaat cacatgtgac caaagaatcc cattgatggt gtcagacaat gacccaggaa 29160 gaggagttca tagcggctgc ttgtttcctt actggaaatg cagggtgaca gcagaactca 29220 gggaacatgg tgctacccag taaaagaaac agtgcatagg ccgggtgcgg tggctcatac 29280 ctgtaatccc agctctttgg gagcccgagg cgggcggatc acctgaggtc aggagttcaa 29340 gaccagcctg gccaatgtgg tgaaacccca tctctactaa aatacaaaaa ttagccgggc 29400 atgatggcga gtgcctgtaa tcccagctat tcgggaggct ggagactcgc ttgaatccgg 29460 gaggcggagg ctgcagtgag ctgagatcac gccactgcac tccagcctgg tgacagagcg 29520 agactccgtc tcaaaaaaaa aagaaagaaa gaaagaaaga aacagtgcat aacaggggca 29580 gggctgtttg caatgtgatg aaagcataat ggtgctgcag tcctgggcct gatgtcatct 29640 tgagactgga tgttggtagg atggtgccct tctgtaatat gtttagtagc tgcacttgct 29700 gaattgacag cctctctgtt taaaactgac aaggagaaaa ttaaagtttc ccctgctttt 29760 catgtcatgc atgaataacc aattgcttgg cagctagtta aaattcatat ttctcttgtc 29820 aggtttttag agactgtgaa gatcaggtta atgtaagcct tccctccttt tgccctcttg 29880 gctaactagc tagttatatt tgcatttctt tttatataaa tctttttttt ttcctgtccc 29940 tttgacagca cagtatcaga gatggcatat tatcttcaga tgtgccatgc tggaaagcgt 30000 ttgctcttat ataaatatag aggcagaaag agactgtctt tcttcgcacg tatccaatcc 30060 ttttaggtat ccaatccttt taatgactcc aagtcaaagg ttgttttttc tcaccaacaa 30120 aaaggatttg tcaactacca ggaatctgag agttttctaa tcctactggg gtgggaagtt 30180 ctaaacattg tgacatagac ttttctattt gtatagagtc actcacagat cctacaccat 30240 gcaattgtat cattgcctca tggaaaagaa gacgctcttc aactttaaca tgtttttgac 30300 acctgctaaa cacctggtaa tgctagcttt ctactcaggt ctcttctcag ctctcttctc 30360 agctctacag attataaatc tttaatgctg acaaaggagt tatcctgctg ctgccagaaa 30420 gaagctacac aaattttgcg atgctgtgag gcaaggcaca aatctcagaa ctgtggaaaa 30480 cagagaatct ttcccttctt cagttgtgtc ttcttgccac aacttccata gaatcgcagc 30540 tgagagtcac tggcagctgt agccacatct tctctccaaa tcacagagaa ataactgagc 30600 ggggaattaa gagttgtctc tgggttgcac aaacaatgtc tcaggaacac gctggccacc 30660 actctgtatg aggaatgaga actggagcgc aggatatgaa tttttctcac cctcaaaaaa 30720 cccaggagag ataccctcct aaggtttata ggaaatttgt tcctgaccca agggtcagag 30780 aatagcttac tatgaatttt aattggctcc caagtaattg ctaattcatc tctgactttg 30840 gcaggaaaaa aaaattaaat gttaaagaaa tgaatttagc aggaagactt ttttcccttc 30900 ttttcttttc ttttttatat gagcacggtc ctacagctgt tgaagcctaa cagagaagat 30960 ggtaaataaa catgcagggc taggggcgtt catttgcaga actttctgct tgaagaggag 31020 cctggaaaac tgcaggactc atttgggatt acaaatcttt tttttttttt tttttttttt 31080 ttttttttga gacagggcct tactctgtca cccaggctgg agtgcaatgg tgctatctca 31140 gctcactaca acctctgcct cccaagttca agtgattctc ccacctcagc ctcctgagta 31200 gctgggatta caggcacatg ccaccatgcc cagctagttt tagtattttt agtagagatg 31260 gggttctgcc atgttggcca ggctggtctc gaactcctga cttcaggtga tccatccgcc 31320 tcggtatccc aaagtgctga gattacaggc gtgagccact gcgccgggcc tggattataa 31380 atctttaatg ctgacaaagg agttatcctg ctactgccag aaagaagcta cacaaatttt 31440 gtgatgctgt gaggcaaggc acagtgggtg cgagatgcag aagggacagg acacaggagg 31500 gcctgtcccc accatgcaag tcacatgaaa ccaaaaccaa cctaacttgg gtttgagaaa 31560 ctaaagtccc aggtgttgga ctcacctctt gtccttgtgg acttcagagg atccgtcttt 31620 gtccctaccc tttcctctca tttcctccct ccccaatttt tttccctgac atttctctgc 31680 tcaaactcac attttctctt atttgatgtc tgctacatat ataacataca acatgtttta 31740 aaatgtatag ttgaatcatc aaacattgag cattctttct gggaatttat gctgcctggc 31800 agataacgtc catctgttca ctcgccattc attgccagtc acctgtgccc ttgtctttct 31860 ctgttgtgga ggctaaagag agaaattttc aacttcccca attgcccatg gctaggtgga 31920 acccgaggag tctggttcct gcttaaatcc catgtgtggc tgggcacggt ggctcacgac 31980 cgtaatccca gcactttagg aggccgaggc gggaggatca cctgaggtca ggagtttgag 32040 accagcctgg ccaatatggt gaaaccctgt ctctactaaa aatacaaaaa tcagcttggg 32100 cgtggtacgg gcgcctgtaa tcccagctac tcgggaggtt gaggcagaag gatcgcttga 32160 acccgggagg cggagctttc agtaagccaa gatcgcgcca ctgcactcca gcctgggtga 32220 cagaacgaga ctccgtctcc aacaaacaaa aacaaaaaca aaacaacaac aacaacaaaa 32280 ccaaacccat gtgtgatttt tttcaggcct gaccgactgc tattccagag gcatcacccg 32340 tcaggcctca ccggaaggct gcacagccgg tgccacctca gagagtctct ggcaagaggt 32400 cagcctcctc tggctgctcc tgcccttttg tggatctgct ttcctagtcc aggtgctctg 32460 ttcggagggc tcagggaccc ttaagggaag acacctttct tcactctgac tcagtacttt 32520 tacactctca gctttttccc ctctcactac ccaactcccc agcccctggt ccacaaccct 32580 tcaggaagcc tttggttagg ggccccctca agagtgagat gacccccaca tctgtgctga 32640 tcctcctgac cctgaaccgt atgggtgcat tgttccaagg ggaaaatgaa gcaggagagc 32700 tcagcactcc ctccagtgtt agcctcttgc ttgtactact gcagtgcggg attaaagtct 32760 tcgctattac ttccatttgt gcttgttgta gcttcaagtg gctactctaa cacctgacag 32820 ctcagctccc ttccagctct actgagctcc tgacagcgcc atgcgatgca atttaatcta 32880 agaggaattc agccgcatgg ttataccggg gcacggtgga gaataaatga cattctgcct 32940 ttgttctgcc taaaatacag gtgtgatgac tggagatgca gaagccattc cattatatca 33000 acataacatg ataagccaag accctaaaga tgctgagaaa aatggtcaaa agagcttggg 33060 gtttttttgg tttttttgtt tgtttgtttt gttttttttg aggcagtggt ctcactgtgt 33120 tgcccaagct ggtctcaaac tcctggcctc aggcttcagc ctctcaaaac tgctaggatt 33180 acaagtgtga gccactgcat gagactgggc tgttttttgt ttggtttggt ttttttagag 33240 acagggtctt gctctgtcac ccaggctaaa atgtagggat gtgatcatag ctcactgcag 33300 cctcaacctc cttggctcaa gtgatcctcc cacctcagcc tcccaagtag ctgggaatac 33360 agacatgcac taccacaccc agctaattaa aaaaacaaag tttagtagag acggaggtct 33420 ccctatgttg cccaggctgg tctcgaactc ctcacctcaa gtaatcctcc taccttggcc 33480 tcccaaattg ttggaattac aagcgtgagc caccatgccc agtactgtct ggtttcttaa 33540 taacattgtt gagccattgc aatagccttg ggatattgct ctttgtactt tttcttatgc 33600 aagaaaaaca gattcacaag ttatttgatg actctcttcc catcaaaagg aaaagtctaa 33660 ttctttttcc cttgattatg gatcagcttg agcttgttgc ttctaacaaa tggaagagag 33720 caacatgctg gagtgatcac atggaggaag cacaaaggga tacatgccca aggggcccca 33780 gctgttccag cccctagaca tttgaatcta ctcaggcacc aagtaagcag gtgaatagcc 33840 ttcaggtgat tgcggcccac tcccagctga agccaagtgg agcgcagatg agcttcccct 33900 gctgagccct gcccaaattg cagatttgga agcaaaatga atattgtttt aagccacaaa 33960 tttgtgagtg ttttgttaca tagtataagg agccagaaca gctctacaga tgtaaattat 34020 agtcagatat gttgctattt ataaccaaag cattcctaac ttataaatgt ttcaacatta 34080 ataagcagaa gaaagtgtaa taatcttatc aaggtaatac aagttacttg tttaatataa 34140 ccaccttcat ggcaagcctc aatttcataa cctaatcact ttgagtacaa cttggaccta 34200 atgggtagct tttttttttt tttttttttt gagacagggt cttgctctgt cacccaggat 34260 ggagtacagt gacacaatca tggctcagca cagtctcaaa ctcctgggct gaaatgatcc 34320 tcctacctca gcatcctgag tagctgggac taaaggcagg ccccactatg cccagctaat 34380 ttataatttt tttttttttc tgtagagatg gagccttgct atgttgccca ggctgatctt 34440 gagctcctgg gctcaagcag tcctccagct caacatcccc aagtattggg attataggca 34500 tgaaccacca ctcttggcct ctgtgtagca ttttatagaa aatataaagt tgatattata 34560 aattttatat taacagattt ctataattaa aaatcttggc tagattgttt ttcctttact 34620 cttttttttt gagatggagt ttcactcttg ttgcccaggc tggagtgcaa tggcaccatc 34680 tcggctcact tcaacctctg cctcccgggt tcaagtgatt ttcttgcctc agcctcctga 34740 gtagctggga ttacaggcat gcaccaccac gcctggctaa ttttgtattt ttagtagaga 34800 tggggtttct ccatgttggt caggctggtc tcgaactccc aacctcaggt gatccgcccg 34860 cctcagcctc ccaaagtgct gggattacag gcatgagcca ccatgcctgg cctcctctac 34920 tctttcatta gtagagttaa tatccattca ttgcgcactt gctatgtgct aggtgctaag 34980 gacacaatag tgaacaagat taatcacctg agatccttgt cctaatgaag cttaccttct 35040 gggggggaaa acatgataaa aatgcagaca agtatgttaa tataataatt tcagatcata 35100 atgtgaagaa attagtgtgg gatatgtggg ggagatgggg aatagatagt tttgctttag 35160 ttaaaatgtc agggaaggca tctctaaaga agaaacatca gagatgagac ctggatgatg 35220 aagggagcca gccatgggaa gttctggggt agaagtgctt cagactaagg gaatagccag 35280 tgcaaagagc ctgtagccag aataaggttg gtagagtcca gaacagaaat taaaaaaaag 35340 tggggacaga gggtggggtg ggggagatgg tactaagtga gagaagggga gcagacagga 35400 cccatatccc ttaggtcctt gtaggccata gtaaagaatc tggaagttat ttctgtaagt 35460 gcaatgttaa aggtactgac aggatatgct ttgcactttt aaaagatcac actatggaga 35520 atggagtgca gaggggcaag agttgaagca aggagaccca ttagaaggct gtggcagtaa 35580 tcaagaagag atgattacgg cttgattaca cattggcaat ggaggtggtg aggagctctg 35640 agatctggga taaattgaga cagagcttga aagagagctg atagaaattg ccaatagagt 35700 gctgacggat ttccacgtcg actggaaagg caaattatta atttatgtga atctcaatgg 35760 ttttgtcatc atttgagtgt accatccggt tgtcccctga gcctacgtgt atggtatttg 35820 gaggataaat agaaggagca caaggatgca gacactaaga gtttaaagct gaagccaggc 35880 atgtcctgtg cattatttca agcaggtgtt gttaattaat gcccctctct ggctgtatgg 35940 caacaagctg tagagcctcc ttctggggcc atccctctag ctctcagttc cttttgttcc 36000 aaatcagagc actagggttt gagttactta ggatctcaca tgaatcattc ttggggaact 36060 aggggcaggg taatgaatgc tactaattag cctgctaagt atcctctgta actagaggat 36120 atttggttgc aactagaaag ctgaggtaat tatctcttta ttatgtacga atcttattta 36180 catgagccac atgggcattt atgaccgatt agctcagata aatggacatc caggctaatg 36240 acaacatcac aaattcattc cctgtagaat ccttctgttt tagggctgta aactctattc 36300 cttgtagtat gaggtggcca gcaagtctgg aaacatagat aatactattt ttattatgta 36360 cgatttataa cccattcatt atgcttttcc ctgtgtttca agaatttggt ggccaccctg 36420 gagacacttc ttggggtatc tttaccaaaa ctcaacatac cagctctcaa accattctac 36480 ctttctgaga cgcaccccat ccacagaagt gggcttccag ggactctgcc catgtgagtg 36540 actcacctag ctggcctcag gtgattggac agagctgaac acttgtttca agcagggcca 36600 atcagattcc ttctcccaga aggaagaaat ggagagacag gcacacggtc tctgtgaatg 36660 agagaacaat cacctctaaa cttgttgctg tggttcagcc atattcagcc ttgtggataa 36720 agaagcagag aaagcaggac tctagtgtca gagaatgagc tagatgtgca aaaaaagtgg 36780 aggaaagatg aaccaagggt gcatcttggg aatgcggatg ctttttcgtt ctcaactttg 36840 cccttcctaa ggtctggctg tactcctgcg tttggttcct caacacactt ttgtatatgt 36900 ataccaaatt ccccctttgt gcctaagtgg agtccttttg gtttctgtca cttgccgccc 36960 aagagtctta actaatatga ctttagatct tgtccacact ctccccaggg aattccattg 37020 gtcataaggg tcaggaagga atacatagat aagtatgaat ccattgtcac tgaagtggaa 37080 acaatttaag agcagtctct tctagaatga taccaatact atcatctgta aacacaaatg 37140 ccagttgcat cccgtcctgc agagcaagga aaaatcctct ttctattcca gaattgactt 37200 ttttctatta gaaaagagtt tccctaaggt actgacagaa gaatctgctc tttgaaaaac 37260 aatttcaaat ccttatacgc cagcagatct gcactaaatg aaaagttgcc ctcagatatc 37320 catggctgca atgtcctcag aaattgtttg caccgtcctt taccaaaacg aactctatca 37380 agtataacca aatagacttg ctttcccggt cttggttcta tgtacaatgc caccaaactg 37440 cattttattt gatgaaaaag gtgatgtttc cagtttcaaa tggttagcaa aaagtagggg 37500 aattaaggct tcttatttta gtgtaatgtg ccttcttgtg tttagatggt aacttcataa 37560 gggcgagcaa agagtatccc cccaaaatgg taaaatactt taaatataac aagaaacaca 37620 agacataagg aaagtaaaag tctaggctgg gcacagtgac tcacacctat aatcccagca 37680 ctttgggagg ctgaggcagg aggatcactt gaagtcagaa gttggagtcc atccggggca 37740 acatagcgag accccatctc tacaaaaata aaaaattagc tgggtgtggt cacatgcaac 37800 ttttgtccta gctggttggg accctaaggc aggaggatct ctcgagccca ggagttcaag 37860 tttgcagtga gctatgatcg caccactgca ctccagcctg ggcaacagag ctaaactctg 37920 tctccaaaaa taaataaata agctatattt tttaaacaag aaaaaaatta aaaaggctaa 37980 caacccaaat agcacaacca gaggcagtgg gtgtggggca gatcagtagg caaattcctt 38040 gagggcaagg gccctttgcc ccagagccaa gcactttgcc tggaatagaa caggaaataa 38100 atgtttacag agtaaaccga ttgtatgaac acatgattga aagtattgat aaaatgaaag 38160 ccagaaaact atattaccca ttgctaatag gacacaaatt ggttgctgtc aaatttaaag 38220 tattaaatac tcttgaattt gtccacgcaa ttgaatctga tatagcctct ggatataaaa 38280 agtaagattc taaaagctca tcaggctccc ctagttactg cttttttttt tttttttttt 38340 tt 38342 <210> 37 <211> 13854 <212> DNA <213> Homo sapiens <400> 37 agtgatccgc ccgcctccgc ctcccaaagt gctgggatta caggtgtgag ccactgcgcc 60 tggccgctgc tcttatacta ttttgaatgt aggccggccg tagtggctca cacctgtaat 120 ctcagcactt tgggaggccg aggcaggtgg atcacctgag gtcagaagtt tgaggctggt 180 tttagtagag acgaaacccc gtctctacta aaaatacaaa aattagctgg gtgtggtggt 240 gggcacctgt aatctcagct actcaggagg ccaaggcagg agaatctctt gaacctggga 300 ggcagaggtt gcagtgagct ttgatcatgc cattgcactc cagcctgggt gacagagcga 360 aactccatct caaaaaaaat tttttttaaa gaatatagat ataagccaca acccgaggac 420 cccaacctcc ccactgcata tgtgaatagg gagttcacta tgaactcttt ctacgtgacc 480 actcttgaga ccttaatggc tgctgtactt gggctgccga actccataaa ggacaagact 540 gaaagattca cctccgacct ggtgtttgca gcctgaggcc agtcctgtca caggtcacag 600 ggaatcactg ccacccgttt taattacagt ctctggaaga agaggccaaa ccccttctga 660 tttgcagaaa gcctggtttc tttatcttat taacaacaac atatcccagc gctccagtga 720 ttacagaccc attcctgaag caatcaaatt gcctatttga aagaaagact atttcctttc 780 cctaatgaat gtgaacagtc ccccagagcc tgaaggtatg gctatgaatg ccccactgta 840 acaatgaaaa actattataa ataaatgaca cagagctgct ctgttcttaa aaatcaccac 900 atgatcaatt tgagagacat gcatgaagat gggactcagg agattttgtt ttaattattc 960 tgcccgaagg aaaacaatac tttgctcttt gctggcaccg ctgtacagag aagcttaaag 1020 agactttgaa aacatgatcc tgttcatcct tctcaaatca caggcagaca cagttgccct 1080 cattttttga aaggggaaac tgaggtgtag acaaatgagt gttttctgtg tttagcaggc 1140 tatttaaaga ctcatatatc atcatatcca acatgttttt atgtctctcc cctactcagc 1200 tgttctgatc attgtatttg aaaactcacc aaaaagggga gaaattaaca aaaggctata 1260 gagaaggtga gcttttactt ttataagctg ccaacttctt aaaataattt taaaatgagg 1320 tgtgtgcacg tgtgcctgtg tgtgcatgtg tgcgcacaca catacataca catgtttgag 1380 tatgccttgg tattggggtc aggaaatagt aaggatagaa agataggaag aagtgagggc 1440 acttcattgc agccaccaaa cccaggagta cctgcccctc cccgaaggct gcagcctatt 1500 agccagaggg cctgggatat agccagcgac tggggctgga ttagcgaggt tgatgaaaaa 1560 ttatgtactt tatagttctg tcagaccagg gtacccttgg aataaaatct tttagaattt 1620 gaaaaaatat ccacttacta gtgaatacag gacccccatc tgagacctac tgctgcccag 1680 gatggcagtt tataattaat atttcatcag gggtcaaact gcagaccacc aagaagaccc 1740 tgtgagactg tattgaaaaa tcaacttgtt accctttgcc attttttaaa aaagaaaaaa 1800 gtgaatccat ttgaaattca tagataggag tctgcgactg caaaatgtcc aataagatta 1860 actaaaaatt cctcaggagc ctgaatattt atatttccag ggattcttta ctgtagtatc 1920 agtacttctt agaagggttt gttgtttgtg gatggcaagt gcctttgcac tgcttctttg 1980 tacaattctt agccacatga ctttcctcag gagttgacag aatcccccac ccccccaaaa 2040 aaattcagag gagccttatt tttgcttact tttaaaggaa gagaacacaa gttattttaa 2100 aaggtttctg gaatttggct atctagatgg tttgacagtg ttaagtgaat caactaatca 2160 cattgaccaa atcactggct aattcagtaa agcaatcagc ttaactaatt gtccaactga 2220 tgatcaaatc aatgaaccgg tcttgttttg gatcttttgt ttttcgtttg ctttgttctt 2280 gacattgggt aggcacagct caagttgtgc aagccagaca ttctcaccaa tacttatagg 2340 aaagaagtgg acaatatact taaaaatgtg agaatccgta tggaaaacag aacttcatta 2400 aagaattaga tggaattaaa tgggttaagc tcatcagaaa aaaaaaaaaa attaaaggaa 2460 aaggctattc ttaccaggga atgaagtctc tgcagaaatt gattatgtag agagtccctt 2520 tgggtcttgg aacaattagc tctcagaaaa ttagaggata gcctttggct tctggggatt 2580 cgaatgtaac aggtgtctgc tgtcccttag gaaattcttc actccttcta gctgctcatt 2640 ttttggctgc ctgcccctgc agggtaaacc caaacccctg agagttaaag attttgagtc 2700 atagagaacc tgaataattg gattctcgga gggcattact tttgcaagat tccgccacag 2760 atgtacttct ggggtgtttt ctgtgataga aaaaagaaat cccttctcct actgagaaaa 2820 gacaacaact aagaggccgt atttcctaca gtgggtaacg gagaggagac aatatttgtt 2880 tctgtccctg tactaacctc attcttagga cagcatgaac actgggggag gtgactaggc 2940 ctccgtcttt cagatacctg agaaaagtga aacgtgatct ctgtggtgat tcaggtagag 3000 ttattaggca tggacagaaa gcagggagtg cacagatgcc tttgtgcaaa ggagagtgat 3060 tttctcattt tacctgctga gaaagagtag aggtatttat gccaggatgg gtgttattaa 3120 acagatgaag gacaatctga cagagttaat taaggatctt gagtgtcagg atccagagaa 3180 agagatatct cgtgtaggag gcaggtatgg gaaaggtaag tccgcaaggg agggtgagtg 3240 cttttcccac aaaggggagg cagcacattc ttgcttcagg gtgaaggata caacacattc 3300 tgaaatgagg tttggaatat tgtgtatttt tagctgctgc tgtgaaaatt cctcctaagg 3360 agagagccat ctttggggaa attgcctctc caagtctccc tgggtagggg ctgagcctcc 3420 agggtttggc taggccaagg cccagctctc agaggccagg gtgaggtaag gctgcctgta 3480 gaggatggaa cctgggaaga aggggaagaa agagatagaa aaaggcttcc agagggacct 3540 gggtatgaaa tgactgggtc tacgcgggat gtgactcctc tctctggctc ttcaaatctt 3600 cataataatc aaactgacaa catgtttggt ggaaatagat tttttttttt taaaccagtg 3660 aagttgggcc cctagagtag aacagagata caatgtgtgg aagtagggtc tggagcagag 3720 gacctctaaa accactatgt ctgtgctagg gacacaggaa ccatagtggg ccccacccaa 3780 tatctgagtt tcagagtaaa acaaaatgag gctttgagtg tgctgtattt taatatgtgg 3840 ttgcagagat caacacgcag caggagaacc actttgcaat ataaaaatct gtctccaggc 3900 tgggcgtggc ggctcacgcc tgtaatccca gtgagaggtg acagcgtgct ggcagtcctc 3960 aaaaccctcg cttgctctcg gcgcctcctc tgcctgggtt cccactttgg ccgcacttga 4020 ggagcccttc ggcctgccgc tgcactgtgg gagccccttt ctgggctggc caaggccaga 4080 gccggctccc tcagcttgca gggaggtgtg gagggagagg cacgagcggg aaccagggct 4140 gtgcgcagcg cttgcgggcc agctggagtt ccgggtgggc gtgggcttgg ctggccctgc 4200 actctgagcg gccagctggc cctgccggcc ccgggcagtg aggggcttag cacccgggcc 4260 agcggctgcg gagggtgtac tgggtccccc agcagtgcca gccgaccggc gctgtgctcg 4320 atttctcacc cagccttagc tgccttcccg cggggcaggg ctcgggacct gcagcccacc 4380 atgcctgagc ctcccaccca ctccatgggc tcctgtgcgg cccgagcctc cctgacgagc 4440 accaccccct gctccatggc gcccagtccc atcgaccacc caagggctga ggaatgcgag 4500 cgcacgcgca ggactggcag gcagctccac ctgcagcccg gatgtgggat ccactaggtg 4560 aagccagctg ggctcctgag tctggtgggg atgtggacag tctttatgtc tagctcaggg 4620 attgtaaata caccaatcag caccctgtgt ttagctcaag gtttgtgagt gcaccaatgg 4680 acactctgtt atctagctgc tctggtgggg ccttggagaa cctttatgtc tagctcaggg 4740 attgtaaaca caccaatcag caccctgtgt ctagctcagg gtttgtgagt gcaccaatcg 4800 acactctgta tctagctgct ctggtggggc cttggagaac ctttatgtct agctcaggga 4860 ttgtaaatac accaatcagc actctgtatc tagctcaagg tttgtaaaca caccaatcag 4920 caccctgtgt ttagctcaag gtttgtgaat gcaccaatcg acactctgta tctagctgct 4980 ctgctggggc cttggagaac ctttgtgtcc atactctgta tctaactaat ctgatgggga 5040 cgtggagaac ctttgtatct agcccaggga ttgtaaatgc accaatcagc accctgtcaa 5100 aacaggccac tcggctctac caatcagcag gatgtgggtg gggccagata agagactaaa 5160 agcaggctgc ccgagccagc attggtaacc cgcttggatc cccttccaca ctgtggaagc 5220 attgtttttt cactctgcaa tgaatcttgc tactgctcac tctttgggtc cacgctgctt 5280 ttatgagctg taacactcac cgcgaagatc tgcagcttca ctcctgagcc cagggagacc 5340 atgagcccac cgggatgaat gaacaacccc agacgtgctg ccttaagagc tgtaacactc 5400 accgtgaagg tctgcagctt cactcctgag ccagcgagac cacgaaccca ccagaaggaa 5460 gaaactctga acacatctga acatcagaag ggacagactc cagacgcgcc accttaagag 5520 ctgtaacact caccacgagg gtccgcggct tcattcttga agtcagtgag accaagaacc 5580 caccaattcc ggacacacca gcactctggg aggccaaggt gggaggatca cctgaggtca 5640 ggagtgcgag accagcctgg ccaacatggt aaaccccgtt tctactacta aaaataccaa 5700 aattagtggg gcttggtggc gggtgcctgt aatcccagct acttcggagg ctgaggcagg 5760 agaatcactt gaacctggga ggcagaggct gcagtgagcc actgcattcc agcctgggca 5820 acaagagcaa aactctgtct caaaaaaaaa aaaaaaatct tgagtggtga ttcttactta 5880 agtgcacaca ttggcacttc tttattttga gggaactgtg gtagtatcta tcaaaactta 5940 aactaggaac aacctccaac tcaataactg ccttatagaa acactcaaat atgtgtatac 6000 ttcaaggaaa ctgccttata gaaatgctca aatatgtgta caaacacata agtgcaagga 6060 agttgttttg aagcataaat tgtaagagca aaaccttgga aataacctga ttgtccataa 6120 atagggaaat agtcaaactg attattatac gattatgtaa tcttcagtat actaattttt 6180 ttttaattgg ggcaaaattc acataacata aaattaacca caaaccattt ttaagtgtac 6240 aatttagtgg catttaatac attcatagtg tgcaactgag acagccaaat gcttaggcag 6300 ataagaaggg gtccccagag aatctccaac ctgccccaca agtgtttaca tcggatgctt 6360 tcgtgcagat gagggactct gcccaaagct ttgtctgggc atgcccacag tggactggag 6420 ctccacatgc gcactggggg aagtgggtgg agccatgggg aattggcacc ctacacaggg 6480 gaggagcctg ctctcccagg ttcctgtgtg gtggccaggg attcagtctg tgaggtggac 6540 ggcatgttac aggtctccat ctcactttgc tgagtgtttt ttttttcttt ttttcctttt 6600 tgcccaataa agtcctgctc tactcaccct tcaatgtgtc cgtgtgccta aattttcctg 6660 gtcgtgtgac aagaacctga gatttagctg aactaaggag taaggttcta caatacaacc 6720 atcacctctc tttaattcca ggacggtgtt atcactccaa aagggagcct catacacatt 6780 aagcagtcac tcctcatcac ccttgagaaa tgatttcttg aatttttgag acagggtctt 6840 gctttgttgc ccaggctgga gtgcagtggt gcaatgatgg cttactgcag cctcaatcgt 6900 tcaggctgaa gcgatcctcc cacttcagcc tcccagagta gctggtatta caggtgtgta 6960 tcaccatgcc cagctaattt atcaattttt tgtacagata gggtcttact atgttgtcca 7020 agctggtctt gaactcctgg cctcaagcca ggagtttccc aaagtgctag gactacaggt 7080 gtgagccacc atacctggct gagaaaagat tttaaatgtc agaatagtat gaacagtgtc 7140 accctatata tgtatgaaaa ccctctaaac tatgtcctat gtttccgtct actgacagag 7200 gcattgcaga atagtggttc taggcagagc tccagaacca ggccgcctgg ctttcaaatc 7260 ctggccctga cacagaccag ctgtgcatca ctgggggtgt gtttagccta tctgtgcctc 7320 tgtttccaca ggtgtaaatt gggcatagtt gtgaagagga aatcagtaag gacaagccta 7380 atacagtcac tgtttagtat acttacttct gtgtttgaag ttttcttttt aaagtcaaaa 7440 tcatgggcaa ataaacctat tgccagtgta gaacacacat tcctagacta ctccctttca 7500 ggacaccagg tgagggctac cccccatcag tgcttgcctc ttgcttaaag ctaaggctgc 7560 agggaggatg catattttca cgccagcaca gagcacactt taaatctcct caacagcgtg 7620 gcagaaatgc aggctttaaa gagcaacaaa atcctgactg acaagattca agggaagtac 7680 ctgatcaggg aagtacaagt acaagattca gggaagtaac tgaaaaatgt aagttttaag 7740 acttacattt gactcaaggg ccagcaggca tttcagacag caagagggag ggtctctgtg 7800 aaggtgagat acccaaagaa gaaggaacag agggaagaag gaaggaaaag gaagaaggaa 7860 gaggggaagg aatggagaaa agaagaaaag gaagaaggga gagaaggagg aaggaaggag 7920 aaaggaaggg aggaaggaag aaggaaagaa gggaaggagg aaagggagaa gaaagggagg 7980 aacaaaggaa gagggtaaga aaaaggaaga aaggaaagag gagagagagg gaataaggaa 8040 ggaagaggaa aagaaaaaag ggttaaaaaa taagttagga tgaaggaaag gaagaaaaga 8100 gaaggtgagg aagtacaagg aaacaggtga gccccagccc tgctgtgatt tcagttctca 8160 gatctaaagt gttcaagtaa aaacaaagca caggcatagc cttctttttt tttttttttc 8220 tagatggagt ctcgctctgt cacccaggct ggagtgcagt ggtgcgatct cagctcactg 8280 caacctctgc ctcccgggtt caagcgattc ttctgcctca gtctccagag tagctgggac 8340 tacaggtgtg cgccaccaca cctggctaat tttttgtatt tttagtattt ttagtagaga 8400 tggggtttca ccatataggc caggctggtc tcgaactcct gacctcgtga tctgcctgcc 8460 tcagcttcct caagtgctgg gattacaggc atgagccacc gcgcctggcc agcacaggca 8520 aagcctttca accaaaaaat caagggagaa ctaagagaag tatttgcgat ttcaattttt 8580 ttctactgag tcctaatcta aatggaggtc agaaactgga caatacaaag ctgccatgcg 8640 tcaaggatgg aacaagcaca gccgcggcca agctcgcaca ttcctaggtg ctttccagga 8700 tgcccctcca gggtgcgtgc ggtggcctcc aggatgcccc tccagggtgc gtgcggtggc 8760 ctccaggatg cccctccagg gtgcgtgtgg tggcctccag gatgcccctc cagggtgcgt 8820 gcggtgtccc agcccccaga ggtgcctgcg gaaactgttg caagggtgat cccctgataa 8880 acctttcact ttgtttctga atcggaacac agccccaagc ggacttgggg ctgctgggct 8940 gccaggggtt tttaaatatt taacaaggtt tggaggcagt gagcacaaag ctcaggtcca 9000 cccaatttct tagcagaagg tggaaatgca agtatggaat tgtcttgcag aaaaacgcag 9060 ttttgaactt ctgtcttttc aaagacaata ttttaaaact caaatgctac gaaactacca 9120 gataatgagg tagttagatg gaattttgct agcatatatt tgcaaatatt ttaagaatgc 9180 tttgtatgct tctgttgact taatgaagtg attgaaaagg gttaagccgt gtttggtatc 9240 ttcaaaatgg cgattttgct tctgataact ttccggaaaa attaaaggtg ttgtgaagga 9300 taaattatag tttgatttga gtcgtcttgt taaaacgtca ttcctctttc tcagcaacct 9360 acttcccgtc ttattaagcc agttgactag ataggtctag gcaattatga cgatgattta 9420 ctatcttcat gctccattgt cactgggagc caagggatgg gggaagggaa ttcacattcc 9480 catcttacgt gtctcttgga gggacaatca agtcctcagc tgtagcgtta aacacagcaa 9540 tagaaagcag agacacagta aagcattttc actgctctta tgagctgaga tataaaatga 9600 gatttatttg caacaatctg atagagaaaa ttgagtcctg agaattgatg tcctagaaag 9660 gctttcaagt cagccaggag ttactacagg acgtgagtca cacagcaaaa tatcaaagag 9720 ttggaggaga aaaaaaattg agctttgaca ttttctgcag ccgctgttaa agaaattgac 9780 caatgtgtac aatacgaatt atggtcacaa ttacaatctt ctccgatcca gtctttccta 9840 acagttggat accttggatc cttagattga tgtcatcatt cagctttttg cttttttaaa 9900 atattcagtt ctactgcaga tgggatgcta aataaacaaa ccccctaaat ggctctctcc 9960 tttcccccca gaggtttaat ccttataaat aactccgaat aattgtgatg tatcttctgg 10020 catttcacat attctgaaaa ttaccattga aatttgaatt taatcatata ataaccccca 10080 aatatatttt aaactgagag tataaactag aagttttggt gtaatctcat ttactcagga 10140 attcatttag tggccactat ttgtcatgat tttaatgtgg gtctgacatt ggtaggtcat 10200 gttcggagtg aagatatctg cagtttttca atttgcataa tccagttagt gcttccagaa 10260 tgtcttccat gtctcttcat gtttgcaaat taccagaggt cacaggtaaa attttaaaac 10320 gtgagagttg ttcatgaaca tactcgggct ttgtcaaaat caggatatct cccttccctt 10380 tgtagtttac tttttttttt tttttttttt tttgataagt aatgggtctg aagcttcagg 10440 acacaagatg accaaaacca gtttttctgc tgggccctct gaattctacc caagataatg 10500 ctacacattt atataacgcc cacacctgct tatgctgcag taattctttc aaaagttcta 10560 gcaatttgga ctcctctttt tatttaattt ggggatttag tcgctaatct acagttactt 10620 ctagaaataa gcagatgact gcttcaaaaa gcaaaaactt tctgacacct tttattaccc 10680 tctagatgaa aatgaggacg gtaataactt tcaaaggtaa ctgatacact caatggtggc 10740 tcaccacctc atttcagaca accagggggg ctcagtgcac agctgctctt ttattctctt 10800 ccaagagagt ttgtgtaaga actttgcaag catttccttt acaatttgtc tttctgggaa 10860 aattgcatat ggcgttggta taacttgctt aatagtcaca atttattaat ttcatcattt 10920 tttctcaaga gaggtagaaa aaaatgacta atcgtgtggt gggtgacaga gagtctttct 10980 ttggaccata aaaggtaact ggatcaagtc cccaaacaat gttactgact taaaaattca 11040 catctgcact gtatttatag ttaccttatt ttttgaccca ttgcttatgc ttgaacaaga 11100 ctcttttttt tttctttgag acagagtctt gctctgtcac ccaggctgta atacagtggc 11160 acaatcacgg ctcactgcag cctccatctg cagcctccat ctcctggtct caagcaatcc 11220 tcccacctca gcctccctag ttgctgggac cacaggctca tgccaccatg cccagctaaa 11280 aaacaaaact ccccgcgccg cctcaccaaa aaaacaaaac aaaacaaggc tcttaagttc 11340 aattttctaa gtaaaaattt gtgaaactat ttttgttgtt tcattaccat tcgtttctaa 11400 gaccaaagga tacatattgt tctctgcttt cttctcccta aagccaaact ttttttttct 11460 ttctttctat ggttacgtca cgttaatttt ttttttttga gacggagtct cgctctgtca 11520 cccaagccgg agtgcagtca cacagtctca gctcactaaa agctccgcct cctgggttca 11580 agcgactttc ctgcctcagc ctcctgagta gctggggctt caggtgtgtg ccactacacc 11640 cagctaattt ttgtattttt agtagagaca gggttttact atgttagcca ggctgctctt 11700 gaactcctga cctcatgatc cgcccccctc cacctcccaa agtgctggga ttacaggcat 11760 gagccaccac gcccggccat gtcacgtaaa ttttaatgag acgaaatatc tatcaagctt 11820 aaaatcatat gagaaatttg aaggaaaatg attgtagatt ttattcggaa aagatactct 11880 gagtcatcag ttattccttt ttttctgatt attaaggctg ataaaaaaaa acctctttat 11940 tttgaaatat gtatgggctc acagaaagct gcaacactta acacatagag ttccatgtgg 12000 tgacatctta tataaccata gtaccatatt aaaaccagta aactggcgtg gaataacact 12060 agtaactaga gtatagacct tactctgcat tctccagttt ttacatgcac tcatgtgtgt 12120 gtgtatttat agttctatgc aatttgaccc cagttataga tcagtacata attactgttg 12180 tagctaacac aacaattagg atacagaatt gttccatcag cacaaaggaa ctccctcatt 12240 ctaccccttt gcatcctccc tctgtccgct gttcataatc cctggccacc actaatctgt 12300 tctccatctc tacacttttg tcatttccag gatgttctat aaatggagtc atacagtatg 12360 taaccttttg acattgactt tttcacccag cataatgtcc ttaagaccca cccagtttgt 12420 cgcatgtatc catagtttat tcctttgcgt ggctgaatag tattccaccg tatggatatg 12480 ccagagtttg cttaaccatt tgccctttga aagacatttg gattgttcac agtttttttg 12540 ctattacaaa taaagctact atcagcattc atatacagac ttattctctg tgtatatgag 12600 cataagtttt catttctctg ggataaatgc ccaagaggat atgattgcta ggttatgtgg 12660 caaatgcaga tttagtttta tgaaaaactg tcaagaaatt ttccagagta gatgtacatt 12720 ttaaacttcc accagcagta taggaggggt ccagttttcc cacatcctcg ccagtaacaa 12780 actttttaga tgagtaagtg aacatgaaaa cattgtgaga tgacaaaggc cacatataga 12840 ctgggcaaag tatgtgaaag gagatatttg gcttgtatat gatcctcaga ccactttttc 12900 aggagagatg gcagcaacat ttgctgtaat ataaatttcc cctgctttta tcagcctgta 12960 gccatgaatc agcagtggct tcaagtgtta gaaaactcaa ctacagccat ttaagcacat 13020 ggggctattt tcctcacaga acaagagatg cagaaatcag cgactgcgga ggcttaaaga 13080 tgatggctgc tgctgctgtt gcttcaggaa tcatgttcac attcctccag gaagaagaca 13140 gaaggagaaa aggcagtgtt tctatcacag aaaaaaaaat tgtttttttt tttttttcag 13200 gaacaccact agtgttctgt tttggtcatg ttgcccagaa cactgcctca gatcccctca 13260 tggctggaac aacatggtag ggagaagggc cttggaatgc tgactgggtc aggaattcac 13320 tattatctgc cacaggggac cgtcaacatt aatggtcaac ctttgccagc ttaaggcttc 13380 ccccagtgat gcatggcctc atcttattgt aatgtcctcc atcgtaaagc atttctgggt 13440 atttctatgg ggtatctcac ttgtgcttat aagcaaagtc cggtcccact gctcaacacc 13500 attgttctct gcaggtcctt gtgaggtaca atgttatctg cagggccctc ccctccccta 13560 agcttccgcc ctggtcctct ggttgtcacc atggaggaac tagaaagttc acgcagttgg 13620 ggctgcattc cttgccaaag tggggagaga gctctccccc ctgctttggg cactctttgt 13680 catgctctgt gccatgcgtt tcatgactac ctttctgaac ccatttcctc acttgagctt 13740 atgaacgttc actcttcatt ggttcataca ttgtccatgg ggctggacag gtgaccagac 13800 acaaggccat ccgttccact gataatgtct ttctcattct tacattccca caaa 13854 <210> 38 <211> 346832 <212> DNA <213> Homo sapiens <400> 38 agcagatggc atttgagcaa acacttgcaa aaggtgagga agatagccat catagctgat 60 ggaacaagca aaacaaaagt cataaggaag aattgtactc gtgtgtttga agacatcaag 120 gaatccgggg cgatagacat agcaagtgag gggagggtat gagaggaatt gggtgggagg 180 cacagtggga ggccagggca tttaagatgt tgaggacttt cggcttcatg cagcataact 240 gagtatattt aagaaagaat gctcattgaa tgttcccgtt acaccatgca ctgaggtaag 300 cgctttattt atatttctct gtgatttttt tggttagtct tcataagaac cctacgtaca 360 aaatagtatt attaatatct atattttatt aacaagcatg tttagtccta aagaagtcga 420 ttaactcacc caaggtcaca tagatggtaa atgatgagaa ctgtatctag gctttccgac 480 acctgtctgt ttgatcatag cattatcctg agtccaagtt gaatggcttc tatttgattt 540 tgcaatgtca aattacctga aatgatgtag acatgcaatt caaagttcca ctgctgtgca 600 aagacttaat tcttgctatg ggctgaaagt ttccattccc ctcaaattaa tgttatactg 660 ctaaccccca aagttgtggt attaggagct ggggaatttg gggaggtgat gaagtcattg 720 ggcagagtcc tcatgagtaa gattagtgca cttttaaaag aggcctaaaa aagactcctg 780 ctcacctctt ccaccatgtg agggcacagc aagaaggtgc catcagtgaa ccagaaagtg 840 agcactcatg aggcatggaa tctgccagtg ccttgatctg ggacttccca gcatccaggg 900 ctgtacgaaa gttctgtagt ctgtgagccg tccagtttat ggtattttgt tatagcagcc 960 caaatgctat atgtacttag cccatgtgga ctaagataat tggtaagagg tcttcacact 1020 ttctcagcta ccagaaagta catttgaatt caactgagga aatctattta gtcattgttt 1080 tgccatgtta cccccaccca acaagcattt gttatgtttt catgttgcaa gttggattct 1140 tggagaggcc tttgggatca acccttgtga aaaggagaga agagaaaggg gaataggcag 1200 aagaggaatg agctgtgatg gaggcccact gatggcctca gctgatctca ccagaagctt 1260 ggcactctgg tggctctcag caagacttta ttcccttaca tcaatccatc attggttgtg 1320 ggcctctgaa ggagtattga ggcacaacac cttacagcat ccaccacaat ctgtagcatc 1380 aaaatgcttt ctgattactt gagttgccct gggtgctaca agggaaatac aagcagactc 1440 taagtgtggt tttattgatg ttgaagtagc ttcctttcat ggaaaaagag gcaaaaacct 1500 cgacatttcc cctatttccc cttctggtgt acagaaatgc atttggtgtg gatctataaa 1560 tttaaagcta ataagatttc tattctactg atgctataac tgtttgataa tctaaaaaga 1620 ttctcaaatg atttttgtgg tggggataac ctagatttgt gaaggtgcac atatgggttt 1680 gtgagtgtgt gttttaaaca tataatagaa atagaagaga gataacataa ggaaatgtgt 1740 cacttttccc aatttttcat tctcatgaat gctcacttct tcctttcgct ttcatggttg 1800 ctgagggtta tttgctggcg ggacaatagt ccctgtgtca aagggctggt gggtcaactc 1860 accaagctaa gctgctgctg acagatgagt gatggaaaga tgtactgttg tatctgtcag 1920 ctctgatgag aaaaagtgga gcttagctta gaatcattct catttccaga tttttatttg 1980 tattgttatt ttattcctga aaagaggatt gatttctttc tgcattatgt aggtctcttt 2040 ttcaatgctc ccgggtaaac caatctcaaa gcacaaagac tgaaattcct ctactttcca 2100 cagtttgtag gcaacgaatt tagaatgtgt ctcatcacca ctttattctt ctcatcacct 2160 cgaaaagtga ctagcagaat tcccacttgg tttataataa aagaaagcaa caatttcatc 2220 tacgaattag catactagta tgaatgcgca ctcttgaaaa taaatgtgct attttgtata 2280 gtcttgtttc ctgagagagc agtgacttgc atttttatat aaacatgctg aattttacgt 2340 gtgtttagaa aaatttggca tacatatttc cagaatactg aaaatctgac aaacccttgt 2400 gccctactgt tgttacccaa cgttccttct ctgggaactg cctattaaaa aatcctgcag 2460 attgtctccc atcccttatt aaaatgtgca ggaaataagc ctaactgtta agtgtatgaa 2520 ggtcttgaaa accatactct gctggctatt gtcattgaca ttaaactccc taaaatattc 2580 taaaacaagg acattcaagt taaccttact tcattattta acactaaaga aggcaacatg 2640 gattctccaa tctctgagat tgttaggaga taagatcttc cagaacctta tcactcaatc 2700 acagaatcaa agaatgtgct cagctaagac acattgattg acaaatcctt tatgcatatg 2760 agtgacaatg tcagctttca ggaagcagag aaaagatgaa gaaaaataaa atctctagat 2820 gactcacaat taactaggac aaattttctg gacatacaga gttcataggt accttgggag 2880 gcgtttataa tgtttgcccg ttaattgaag catttattta tttaataatc aaacatttat 2940 tgaatgccta tggggatcca ggatttaaag atacagagct taaaaactga gaccttgcct 3000 ctgctatagg gatttacaga aaaagaaatg aatttataat gcaatagaac gaaggcatct 3060 ctggaagcac gctcaggaat atggaaggat atgggctgga aaccaaaccc aaatagcaga 3120 catggaggaa gatgttttgt tttttcttca ggaattccac gtgacttcat ataagcttga 3180 aatatgagta tggataggcc aggaggccca ggaacaggga ttggtgaagt ggtagtgatg 3240 gtgggttggg gttacataaa ggagagaaag gacagcacat tcggagtcac caaggggcag 3300 gattgagaaa ctgcaagcaa ttcaagatgg cgggaataga actgatgagg ctagaaataa 3360 agaggttgat ctataagagg aggacaaggg ccagatcgag gccttataag ccctgctaag 3420 gaatttgaat tttatcatga aggcaatagg gacccagtga aggctaagta gggagatcct 3480 atggacattt ctgctttaga gctgggagtt acacacaggg gttttaaatc cattagggcc 3540 atgaaattag atattcagac cggtatattt tcttaatgaa atagaatcaa ttataataaa 3600 aaggaaatct taaaatacat tgcaagtagt aatagtaatt aatttgtttt atacaatttg 3660 tgtagtaggt cacaaagtaa gtttttgtta ctgagggtgt ggccaaaata atttgagaag 3720 cagtaattta gaaagatctt tcaggcagct gaaagcaggg agagcagtta aaagattatt 3780 cctagaacca tattatacaa gaggagagaa gtgggtcctg cagaatcatg ggaagatggg 3840 aggacacgtc atttcattcc tgtgatgtct ctgaggtgac taaagcctcc agactctgca 3900 tttcatagat tgcaacatga gacatggatg cctatgacct ctcaaaggaa gggcttccac 3960 catgtttgca gtgctgcttt gctgttccct ccacctcaga tgatagtgct tcatttctac 4020 atgaaaggtc cattattcga aagacagctt aaagtgttgc attttccatg aaatttcctc 4080 agatctccct atctagaaat aacctagcat caatcctttc ttccactgta ttagtcattt 4140 gtgtagcatg ccccataaat cccttcttgc tgcatccacc tgttgaatgg tcttcagaat 4200 aatcaacact atttgaaaag tgcttacaag tgtctttgca tttcttcctt ctcttccctc 4260 ttctagaatg tgagacactt gagggcagga gtggaactgt cttcttcact atttcaaggg 4320 ccaggaaagg gagtgacatt gagaagagac tgaataaaaa gttattaaat gaaggaatgg 4380 atttaaaagc accctgatct gcagtgtacc tgaaacagca tatacttcat atcacaactg 4440 tagtatcttc atccttgctc atgttttttc cactgcacta aagtgcttct ttaaatagaa 4500 gaatcaaaat agtgggattc aatgataagt agatgctatt ttgaaatttt attttgatta 4560 gaaatggatt gcagtaatat ttttactttc tgtggaatgg ttatgtacat aataaatact 4620 ctgcctgcat tgtatttgca aaacatcgat gtctttgatt ttgtggcttt agaaagtttt 4680 tcaaatacaa attcaatctg ccattgtttg tgtgagttgg ggaaagaagg gcccacacat 4740 tttggagctt cccaaatgga catgttggca atgattccat gagtcctgtc tctgaagtct 4800 ttgggaaggt ctccaacctc ctgcccactt atttttttcc ttgtttattt ttatggagga 4860 agccaaaatc aagttaagga tatttaatta taggctgtgg ctttctttag aattaaaata 4920 atcagtgata tattaccatt ttgccaaaca tctcatgatg ctcttgtttt taaggatgac 4980 aataattttt aatttaaaat gcaaacaaac ctgctgctta gccctttgtg ctttacctgt 5040 tgagagtatt tggaaatctg acattggaag gcttgtgtta cctttcatca ggttcaacaa 5100 ggcagtagca acataaagaa aaccctgggg agtcagactc atgatacact cataggctta 5160 tttagcgtta agatacaaat atctaggatg tgaagtccac gctaatggtt gatggaagaa 5220 tttaaattat tgctataacc tgaccatgca caattgtcta actcttactt tggattgatt 5280 gcttatatgt gatgtcataa tgtggttaag aaaggcaaaa atttactgaa atcaaaatac 5340 ctggattgta attgccgttc tgctataagt tagttgtgca ataattagag gattctaaaa 5400 caaagctata acagcaacaa caaatataga caaatgtagt tgaattcaag gaattataga 5460 caaatttaaa atcaaattct actttcagca cttaccattt ttgttagatt gagcaaggcc 5520 ctgcacctct cagagcctca gttttctcat ttgtgaaaaa tggtgcatca cgagcttatc 5580 agaattcact gagttgtgtt attgaaatgc ctaggaaaaa tgctggggat attatttttt 5640 tgtataacta aactcaggtg aactgaagca ctgctggagc tgttttggga gaaagtgacc 5700 aagatctaga agaggtggga aaagagtctt gaacaaagag tacttggagg atgaaattca 5760 gtaattcaaa cttaaaataa ttcagacgta aagctgttgg aactttattc tgaggaatgt 5820 ggctgtgaag cctgagtcgc atggcatgcg gatgcaactt ccgtcttttt tctgtaaaca 5880 ttcaggacca aatagtgcca aagaaaagac acctccccca cctcagatta tcctcctcat 5940 ggagtaataa agtcctcttc cttgtagcta atcaaatcac tggggtgttt gcactggtct 6000 tgtataaaaa atataatcct gctaaaattt ctatgtaaag gaaaccatac cttctctact 6060 ttggaatgct ggccccattc ctttggagtc gatgtttctg ggtggcccgc ctcaaacttt 6120 gcctcaaaga aactgtatac ttaatcatat tttctgaatc tcattattta aagttgacag 6180 gaggaactgg gaagttcaca gtggagaaga gaagggagca tattaaaaag agaagtgggt 6240 tgagagttgg aaatatgatt tatccactca gcactgccac taaatatgta tgccatggga 6300 ggctggtgac tgtcctattc tggaccaatt tttcttggct taaaaaatga gaaagttgaa 6360 gtggatgacc tttgaagtct ctcactgctt tcacaatcac ttgagtctga ggataaaccg 6420 agcagctact tgcacatttt taaaagtatt aatatatggt aggaggaata gacttattca 6480 gtgctgctat ggaaggcaga acaagtcgtg aaagttatat tgagaaagaa tatttgctta 6540 acataaaaaa gggcctctca aaaaattaga attatttaat gatagaaaag ctgccttaga 6600 aggtggtaag ctccaatgtt gagattttaa gtctctgtat ttcctctaaa tatttagaat 6660 attcttcctt tcactttttc actaagccgg ttcatattaa gatacaacca acttatcacc 6720 tttttggggg aaacttccta gggtttctct gtctggtaaa atcatcccct ttcttttccc 6780 tcagactttt gtgcttatct ctattttggg ggcctatttg ggggcaaaaa tttgtcatga 6840 tgagaaattg aaacctctcc aaaatggaag aatacttgaa aaattatggg atagccatgt 6900 gataaaatac ttcacaatca tttaaaattt tgttcatgaa aagattgttt tgaaatacaa 6960 aattatgtta ttttataatg ctacctgaga aaagaaaggt acaaattgta tatttaagta 7020 tagtcttctt tttttttttt ttaaacgttg tttcactctt attgcccagg ctggcatgca 7080 atggtgcaat ctcggctcac tgcaacctcc gtctcccagg ttcaatcagt tctccggcct 7140 cagcctcctg agcagctggg attacaggca tgcgccacca tgcctggcta attttttgta 7200 tttttagtat agacggggtt tctccacgtt ggtcaggctg gtctcaaact cccaacctca 7260 ggtgatccac ctgccttggc ctcccaaagt gctgggatta taggcgtgaa ccactgcacc 7320 tggcctaact ccaactgttt taaatgtgct tataaacact tgaatagaag ggtatatata 7380 ttaaaatact cattttgaaa gtgggcaaat ctttacaggc aaatatttat tattttatct 7440 acatttttct ttattttctt atgttctcaa gtgagcatgt ctgcttttat aatataaaaa 7500 ttgttaaaat agaaaaacaa taacttgtat tttgaaaacc aagaaaatag ttgatattca 7560 attacctgga tttctggatt gggttttgtg ctgtcacaaa ttgtgccgtc acaaatgaca 7620 cacatgacac acaaataaca caaatgacac aaatgacaca aaactgtcat gcacaattcc 7680 tgatgaataa tctttttatt ttgcaagcat cttttgtcct tcatcctcat ccagtatcca 7740 gcatcacagg ccaccgcagg aaagctgagg ccccgtggac aatgaaacca cataaactga 7800 gctcagagaa atgcagcttg atgaaataaa gtagttgaaa tggaaaaata gttccctata 7860 ttcttcctga ttccttcagg ttacctgctc caactatggc taaagtgctg gagagttttg 7920 attgccagcc acttcttgat catttctttg agtctctatt ctttcctggt ttaagctttt 7980 aaccctatcc ttccagagct cctggcatga aaggggctaa ggtcctagtg atcgtaatac 8040 aacaaaactc tgatgttgac tccagggagg gaaagaattc aacatcaatg tgctatataa 8100 tccaaagaaa ggatttggtt ttattgtgag caggtgactc aagtcaggtg cctgcaataa 8160 gctagaaaaa ggcaactttg tgaaagttat caagctgtta atctagttta atctcctcaa 8220 ccagcaaaca ttgggaaaga gcatacaata ttccaggctc agtgctaggc atttagggta 8280 acataaaggt aaagaaatct caaggtactc atcagggatg gcagcaagca gagatgtgaa 8340 gaaacaatta cgatgctgag ccataggcac aactctacac attatccaca gtgtatacac 8400 attatacaca tacatgtgca tgtgactgtg tcttccaact taggcggaca tgaacaatga 8460 gaaaaagagt tttaagactg aatgagaatt taccgaaaaa tatgagcaaa ggaaaaaaga 8520 ggtttttagg tggatgaaag tgcccaggta gatccttaga catatgaata ggtatatgtg 8580 atgggagatt aattgtttac tttcattaat atttagtggg agcctatgca tattaggaac 8640 tatatcagga actgttttag gtaatgagaa tcccaagctg agcttatatt gtgtcaggaa 8700 gggagaaaat aaacctatta acaaataaaa gtataattcc tactctgccc tcaaggaggt 8760 ggagcttgtc ttcctacccc ataagtgtgg gtagcatata gtgcctttct ttcaaagaac 8820 acagcgtgga aaagagtagg aggagaaaca acttcccagt ggagaaacct gacaaacttt 8880 tcctccacca ggtcatgaag gtcaacatca acagtcataa atcatgtgta taacatttac 8940 ctttgataca ctgcgatgaa aagggcactt cacctctgca gtctttctcc ccagaacaca 9000 taaccctagt ctaatcatga gaaaaaatca gacaaatttc aaaagggaaa aattttatag 9060 aatacatggc caatgctcct gaaaacatta aaagtcatca aaaagcagta acgtgtgagg 9120 aattatccca gcagagagga gaccaaggag acatgacagc tgaatgtaat gtgttgtcct 9180 ggatgggatc ctggaaggga aaaaggacac taagtaaaaa ctaaggaaat atgaataaag 9240 tatggacgtt agttaatcat aatgcattga tattgtttta ttcactctga catatgtacc 9300 cctaatgtaa gttgttaata acaggggaaa ctgagtgtat gcaatatgga ctctataaca 9360 tcttcataat ttttctgtga atctaaacca ttttttaaaa atatataata ccaagtcggt 9420 tgatgataag tgctatgaaa catagtaagg caaggaatgg ggtcaggaag gggctgggga 9480 gtgaggagtc ttttggcaaa ggtcctaggg gaggcctcca tgagcaggtg tatttgaaag 9540 agtcctgagt gaagagggag agatcatgcc agcacatggg aatgcagatc ctaaggccaa 9600 aaggctgaga caggcttgtt gtgtttgaag gacagcacgc atgcaagcat gcatagagca 9660 cagtgagcta gcgggagtac gatgaggtta gagaggaagc tgaggctaga ttatgtaaaa 9720 ctttgggggt catagtaaag gatttgaatt ttacttggag taagattgaa cagtgttgca 9780 tgatttgcct tgtatattcc tgagatttac ctggttgttg cctgaactat agatagtaga 9840 gggcagagtg gaaacatgtg aacacttagt aacctattgc agtggactag ttaaatgtcg 9900 atggctacct gggccaggat ggcagtggtg gcattggtaa gtagtagtca ggtcttggat 9960 gtgttttgaa gaaacatggc atgctgatgc atgagaatca gggaaaagga aaaaattaag 10020 gatgttttaa aattctttgg gaaattgggt ggatggtaga taggtggtct gagtccataa 10080 actgaatgag aagaatggtg gagtaaaagg gtgcagatgg ggttaataga tttgatggtg 10140 taaggctgaa gaccttctct gattaaatct attttttttt tttttggaaa atgagaagca 10200 ggtcagtaag ctgggaggaa cttagggagc aacagatttc agtgttaaaa caagaattca 10260 aattgagaga tgtgaagttt gagattcatg ttaggcttcc aattagagaa tcagatggtt 10320 agttatgtag atgactttgg aaagcaaggt agtgatagga gctgaagtat acacttagtt 10380 accagtttat atgagtgttt aatcaagcat aaattgtgag tttacatagg gaatgaccgt 10440 aagttagagg tgtctgaaga ctgaggcctc tggaactgca agagtgagtg gtcagaaaga 10500 aaataattta acaaatggac attccattga tgtggaagta aaagcaaaca gtgattgtat 10560 tgcaggagcc aaatgcaaaa gttgttttaa gatagaaatc agttggaaat gggttccaag 10620 atggccgaat aggaacagct ccagtctaca gctctcagca cgagcgatgc agaagacagg 10680 tgatttctgc atttccaact gaggtaccgg gttcatctca ctggggctca tcggagagtg 10740 ggggaaggac agtgggtgca gctcaccaag cgtgagctga agcagggcga ggcatcgcct 10800 cacctgggaa gtgcaagggg tcagggaatt ccctttccta gccaaggaaa ggggtgacag 10860 atggcacctg gaaaatcggg tcactcccac cctaatactg tgcttttctg atggtcttag 10920 caaacggcac accaggagat tatatcctgc acttggcttg gagggtccta cacccacgga 10980 gcctcgctca ttgctagcac agcagcctgg gggaggggca cccgccattg ctgaggcttg 11040 agtaggtaaa caaagcggct gggaagctag aactgggtgg agcccaccgc agctcaagga 11100 ggcctgcctg cctctgtaga ctccacctct gggggcaggg catagccaaa caaaaggcag 11160 cagaaaccgc tgcagactta aatgaaccct acagcttgga agacagtagt ggttctccca 11220 gcatggagct tgagatcaga gaaaggacag actgcctcct caagtgggtc cctgacccac 11280 gagtagccta actgggaggc acaccccaat aggggcagac tgacacccat acggctgggt 11340 acccctcttg gacaaaactt ccagaggaac gatcaggcag caacatttgc tgttcaccaa 11400 tattcgctgt tctttagcct ccactgctga tacccaggca aacaggttct ggagtggacc 11460 tccagcaaac tccaacagac ctgcagctga gggtcctgac tgttagaagg aaaactaaca 11520 aacagaaagg acatccacac caaaacccca tctgtacatc accatcatca aagaccaaag 11580 gtagataaaa ccacaaagat ggggagaaaa aagagcagaa aaactggaaa ctctaaaaat 11640 cagagcacct ctcctcttcc aaaggaatgc agctcctcac cagcaatgga acaaagctgg 11700 atggagaatg actttgacga attgagagaa gaaggcttca gacgatcaaa cttctcccag 11760 ctaaaggaag aagttcgaac ccatggcaaa gaagctgaaa accttgaaaa aacattagac 11820 gaatggctaa ctagaatagc caatgcagag gagtccttaa aggacctgat ggagctgaac 11880 tacgtgacca atgcacaagc ttcagtagcc gattcgatca actggaagaa agggtatcag 11940 tgatagaaga tcaaatgaat gcaataaagt gagaaaagtt tagagaaaaa agaataaaaa 12000 gaaatgaaca aaccctccga gaaatatggg actatgtgaa aagaccaaat ctacatctga 12060 ttggtgtacc tgaaggtgac agggagaatg gaaccaagtt ggaaaacact ctgcaggata 12120 ttatccagga gaacttcccc aatctagcaa ggcaggccag cattcaaatt caggaaatac 12180 agagaacgcc acaaagatac tcctcgagaa gagcaactcc aagacacata attgtcagat 12240 tcaccaaagt tgaaatgaag gaaaaaatgt taagggcagc cagaaataaa ggtcaggtta 12300 cccacaaagg gaagctcatc agactaacag ctcatttctc aaaagaaact ctacaagcca 12360 gaagagagtg gtggccaata ttcaacattc ttaaagacaa gaattttcaa cccagagtca 12420 tatccagcca acctaagctt cataagtgaa ggagaaatga aatactttac agacaagcaa 12480 atgctgagag attttgtcac caccaggcct gccctacaag aacccctgaa ggaagcacta 12540 aacatggaaa ggaacaacca gtaccagcca ctgcaaaaac atgccaaatt gtgaagacca 12600 tcagtgctag gaagaaactg catcaactaa cgagcaaaat aaccagctaa catcataatg 12660 acaggatcaa attcacacat aacgatattt accttaaata taaatgggct aaatgctcca 12720 attaaaagac acagactggc aaattggata aagagtcaag acccatcagt gtgctgtatt 12780 caggaaaccc atctcacgtg cagagacaca cataggctca aaataaaggg atggaggaat 12840 atccaccaag caaatggaaa acagaaaaag gcaggggttg caatcctagt ctctggcaaa 12900 acagacttta aaccaacaaa gatcaaaaga gacaaagagg ccattacata atggtaaagg 12960 gatcaattca acaagaagag ataactatcc taaatatata tgcacccaat acaggagcac 13020 ccaggttcat aaagcaagtc cttagaaacc tacaaagaga gttagagtcc caaacaataa 13080 taatgggaga ctttaacacc ccactgtcaa cattagacag atcaacgaga cagaaagcta 13140 acaaggatat ccaggaattg aactcggctc tgcaccaagc agacctaata gacatctaca 13200 gaactctcca ccccaaatca aaagaatata cattcttctc agcaccacac tgcacctact 13260 gcaaaattga ccacatagtt ggaagtaaag cactcctcag caaatataaa agaacagaaa 13320 ttttaacaaa ctttctctca gaccacagtg caatcaaact agaactcagg attaagaaac 13380 tcactcaaaa ccactcaact acatggaaac tgaacaacct gctcctgaat gactactggg 13440 gacataacga aatgaacgca gaaataaaga tgttctttga aaccaacgag aacaaagaca 13500 caacatacca gaatctctgg aacacattta aagcagtgtg tagagggaaa tttatagcac 13560 taaatgccca caagagaaag caggaaatat ctaaaattga caccctaaca tcacaattaa 13620 aagaactaga gaagcaagag caaacacatt caaaagctag cagaaggcaa gaaataacta 13680 agatcagagc agaactgaag gaaatagaga cataaaaaac ccttcaaaaa atcaatgaat 13740 ccaggagctg gttttttgaa aagatcaaca aaattgataa accgctatca agactaataa 13800 agaagaaaag agagaagaat caaatagatg caagaaaaaa tgataaaggg gatatcacca 13860 ctgatcccac agaaatacaa aataccatca gagaatacta taaacacctc tatgcaaata 13920 aactagaaaa tctagaagaa atggataaat tccttgacac atataacctc ccaagactaa 13980 atcaggaaga agttgaatct ctgaatagac caatagcagg ctctgaaatt gaggcaataa 14040 ttaatagctt accaaccaaa aaaagtctag aaccagacag attcacagcc gaattctacc 14100 agaggtacaa ggaggagctg gtaccattcc ttctgaaact attccaatca atagaaaaag 14160 agggaatcct ccctaactca ttttatgagg ccagcatcat cctgatacca aagcctggca 14220 gagacacaac aaaaaaagag aattttagac caatatccct gatgaacatt gctgaaaaag 14280 tcctcaataa aatactggca aaccgaatcc agcagcacat taaaaagctt atccaccatg 14340 atcaagtggg cttcatccct gggatgcaag gctggttcaa catacgtgaa tcaataaacg 14400 taatccagca tataaacaga accaaagaca aaaaccacat gattatctcc atagatgcag 14460 aaaaggcctt tgacacaatt caacaaccct tcatgctaaa aactctcaat aaattaggta 14520 ttgatgggac gtatcttaaa ataataagag ctatttatga caaacccaca gccaatatca 14580 taatgaatgg gcaaaaactg gaagcattcc ctttgaaaac tggcacaaga cagggatgcc 14640 ctctctcacc actcctattc aacatagtgt tggaagttct ggccagggca atcaggcagg 14700 agaaagaaat aaacggtttt caattaggaa aagaggaaat caaattgtcc ctgtttgcag 14760 ataacatgat tgtatatcta gaaaacccca ttgtctcagc ccaaaatctc cttaagctga 14820 taagcaactt cagcaaactc tcaggatacc aaatcaatgt gcaaatatca caagcattct 14880 tatacaccaa taacagacaa acagccaaat catgagtgaa ctcccattca caattgcttc 14940 aaagagaata aaatacctag gaatccaact tacaagggat gtgaaggacc tcttcaagga 15000 gaactacttt cactgctcga tgaaataaaa gaggatacaa acaaatggaa gaacattcca 15060 tgctcatgga taggaagaat caatatcatg aaaatggcca tactgcccaa ggtaatttgt 15120 agattcattg ccatcccatc aagcaaccaa tgactttctt cacagaattg gaaaaaaact 15180 actttaaagt tcatatggaa ccaaaaaaga gcccacattg ccaagtcaat cctaagccaa 15240 aagaacaaag ctggaggcat catgctacct gatttcaaac tatactacaa tgctacagta 15300 acccaaacag catggtagtg gtatcaaaac agagatatag acaaatggaa cagaacagag 15360 ccctcagaaa taatgccaca catctacaac tatctgatct ttgacaaacc tgacaaaaac 15420 aagcaatggg gaaatgattc cctatttaac aaatggtgct gggaaaactg gctagccgta 15480 tgtagaaagc tgaaactgga tcccttcctt acaccttata caaaaattaa ttcaagatgg 15540 attaaagact taaacgttat acctaaaacc ataaaaaccc tagaagaaaa cctaggcaat 15600 acccttcagg acataggcat gggcaaggac ttcatgtcta aaacaccaaa agcaatggca 15660 acaaaagcca aaattgacaa atgggatctc attaaactaa agagcttctg cacagcaaaa 15720 gaaactacca tcagagtgaa caggcaacct acagaatggg agaaaatttt tgcaatctac 15780 tcatctgaca aagggctaat atccagaatc tacaaagaac tcaaacaaat ttacaagaaa 15840 aaaacaaccc cctcaacaag tgggcgaagg atatgaatag acacttctta aaagaagaca 15900 tctatgcagc caacagacac gtgaaaaaat gcttatcatc actggccatc agagaaatgc 15960 aaatgaaaac cacaatgaga tgccatctca caccagttag aatggcgatt attaaaaagt 16020 caggaacaac aggtgctaga gaggatgtga cgaaatagga acacttttac actgttggtg 16080 ggactgtaag ctagttcaac cattgtggaa gtcggtgtgg tgattcctca gggatctaga 16140 actagaaata ccatttgacc cagccattcc attactgggt atatacccaa aggattataa 16200 atcatgctgc tataaagaca catgcacacg tgtgtttatt gtggcactat tcacaatagc 16260 aaagacttgg aaccaaccca aatgtccatc aatgatagac tggaataaga aaatgtggta 16320 catatacagc atggaatcct ctgcagccat aaaaaaggat gagttcatgt cctttgtagg 16380 gacatggctg aagctggaaa ccatcattct cagcaaacta tcataaggac aaaaaaacaa 16440 acaccgcatg ttctcactca cagttgggaa ttgaacaatg agtacacttg gacacaggaa 16500 ggggaacatc acacaccggg gcctgttgtg gggtgggggc agggggaggg atagcattag 16560 gagatatact taatactaaa tgacgagtca atgggtgcag cacaccaaca tggcacatgt 16620 atacatatgt aacaaacctg cacattgtgc acatgtaccc tagaacttaa agtatattta 16680 aaaaaatgct gggtgcggtg gctcgcgcct gtaatcccag cactttggga ggccaagggg 16740 ggcggatcac gaggtcaaga gatgagacca tcctggctaa catggtgaaa caccgtctct 16800 actaaaaata caaaaaatta gctgggcaag gtggcagggg cctgtagtcc cagctactcc 16860 tgaggctgag gcaggagaat ggcatgaacc ccggtggggg agcctgcagt gagctgtgat 16920 cctgccactg cactccagcc tgggcgagag tctgactcca tctcaaaaaa acaaacaaac 16980 aaacaaaaaa caagaacaaa acaaaacaaa acaaaagagc acctacctcg tagactgctg 17040 tgaatcttaa aggtgccaat gcacactaaa actttgcata tttccaggca catagcaaac 17100 ccttagcatt acctatctca atatttttct tggttttgtt ttgaataaaa gcatttggac 17160 ctaattttaa ttgttaatta taataaataa tttatttgtg aaaaaaagat agaaatctat 17220 tgtgtcaaat gctacaaaga gtcaattaag taagttcagg tgtgggaact gaccagtgaa 17280 ttaactccct tgacaaatgc gtgttagggt aatgatgagg ataaaggcat gactcgatgg 17340 aattcaagag agattaaagg gtgagagagt gaaaacagtg taagcaacac ttgctgtaac 17400 ttttgtcaaa acgaggaagg aaatgttaat ggtatctgtt gaaggaaata aaaaaaattt 17460 tcctattggg tatttattga gcacaatttt tatttggtga aaatgatcca atagggaaag 17520 aatagttgat ggcatgcaaa gagatgggaa aaattgtagg agcaaagcac tttagggaca 17580 agaataaata ggacccaggt cacaaataaa gggatttgct tagatagggg gtctgagtcc 17640 attcactgaa tgagaagaat ggtagagtaa aagggtgcag atggggttaa tagatttggt 17700 gtatggctga agaccttctc tgattaaatc tatttttttc agaaaatgag aagcaggtca 17760 ccagctgaaa atgagggggg tggagtgatg atttagtatt ttaaaagcga agaaaaagtg 17820 agaaatagtt gttttggtga gtaagagagt gaattggatg agcaaatata atagatttcc 17880 tggacagagt ttggatcata catttgaagt taagcacagt tagcatgtac tgtgatttct 17940 ccagcttgaa tcatcttgca aggatgatag agacaaaagc aaaagtcgaa tttaagccaa 18000 aattcggatt tcgtagatga ttatgatgaa ggaaacaggc aagaaaaaga atgacataga 18060 caagtaatga gatgataaca atagatgaat catacagact ttcgactgaa tacaaaggta 18120 gtgacaaact gatggaaggt ggagaagaaa aggggaaaat gttaatggaa tcacagacct 18180 atctgatgag ttgttggagt gttggagtga gagatctaga gaaagtagaa atggaaaaat 18240 gagtgttgct acacagaaga ctagatgctg aggtgaaata tttaattatg tttgagttat 18300 tggtaaggac agtctaagaa atggcctggg aagtggggac agttagacaa aggaaggtgg 18360 aaatgtaaga tggggtgttt ggaagataag aagacaagct attgagaagc ttgagtagta 18420 gatggttttg agtgatcaag gatgatgcta agagtagtaa gcagtggaga aaccgagcta 18480 aattaggtgc taaaaatctt gcaaaaatta ggaggattgc tcagaaggat agcaatgtga 18540 caaaggaaaa tagtggctgg tataactttg cagtgtattt gtcaaagaag ctggaaggtt 18600 tagggaggat gaaggagcaa tattctggaa ctgacaatgg agatcaaaga ggatacttat 18660 cctaagccca gtgaaataag aaagatatca cgccatggga gggctgtagg gaaggataac 18720 ctctggggag agccaggttt gtagaatgga aggtaaaata tttagagaag tggttgaata 18780 tataatatgg agattttact tttcctagag tttaaattct ggagaaagta ttttgaggag 18840 tctggaaagg attacagctt gagtcccatg agggaactta cagaacagtg gatggaagaa 18900 caaattttga cttattgtag taatagagac aaaaagggca tcatgctagt gttctcttat 18960 ggagaggggg aaactaccag agtatacaca aagactaaag aacagagtat gaatatcttg 19020 attaagaaag gtcacttgag caattcctag tgatgtagca gacagtgttg gatggagaga 19080 aagtggagtt ctataagcct ccaggaaatc caactgtggg tattgttgat accaaaactg 19140 aagctaagac agcaagctaa agtcatggga agaagattgg acttagtctt taggcattag 19200 gatgctgtat taggttgaat aatgacactc tctgatatgg ttaggcttgg tgtccccacc 19260 caaatcttga attgtaatct ccataatccc catagtccct tcatatcaag ggagagacca 19320 ggtggaagta atggaatcat gggtgcagtt tcccccatgc tgttctggtg atagcgagtg 19380 aatctcacaa gatctgatgg tattataagt gtctggcatt tccccttctg gcacttctcc 19440 ttcctgatgc cttatgaaga aggtgccttg cttcgtcttc accttccacc ttacaccatg 19500 attgtaagtt ttctgaggcc ttcccagtca tgcagactgt gagtcaatca aacctctttc 19560 ctttataaat tgccccatct caggcagttc tttatagcag tatgaaaaca gactaacaca 19620 ctccctcccc aataatatgt tcataaccac caaacctgta aatctaacct tatttggaat 19680 aagtgacttt gcttttgtaa tgaagttaag gatcttgaga tataatcatc atggatgagt 19740 ataagcctta aatctaatga catctttata agagaagaga agataaaaga agataaaaga 19800 agagaagaga agagaacaaa gacacagaca cagagaagaa tgcgacatga agacagaggc 19860 agagattgga gtgaggcaac aagccaaagg gcaccaagga ttgccagcag ccatcaggag 19920 ccaggataga ggcatagaac agagtctacc tcagcgtcca gaaggaacca accaaatacc 19980 ttggcttcat actctagcgt ctagatctgt gagtaaatgg gcttctgtgg ttttaagcca 20040 ttaaatttgt ggtaatttgt tatgacagtc ctagaacact aatccatatg cctaagtaag 20100 aataacttag tcacatatat gaacacatat gcatgacttc tcgcactttt gaagcagcta 20160 attttcagag acctgtggcc agcatggtct gagatgtcct cagcccagag tgcttattga 20220 attgatagaa acacatagta attgcattac tgaatgctat tctaatattg tgttagaaat 20280 aactttatgt taacagaatg tgcaaagaga ttggaataaa ttaggtgcat gagaaaaaaa 20340 tattgtgtgt aaatgaaagc aggtcaaata tttcagtaga tgagttaacc caaagacagt 20400 tttctgaagc tggcaggact ccttcttcat aagatcagca agaactgatt gaccaacatg 20460 ccttggggta tgaagggaca agaagtgtca tctgacctga ctttgtgcct tgacttagga 20520 ctggccccca aaatacacca cagaaaacaa aataacacat ctctgcagaa attctcttgg 20580 actctttctg tttgttcttt agtcttcatg gattctctgg tagtttctac tgtcttcccc 20640 catgatgtgg agaagtttcc tccagtctgc ttcaccctgt aaagtagatt gtccgtgatc 20700 atggctatgc catgaggaat cgctgtagtt tcccaatgac atcctggtat tggctcacct 20760 ggtagatgct tcctctggct tctctgtgat aggtgataga cttttgtgtt attcatttgt 20820 acatcaattt gaccaatatt ttacctctta ctctttgcca agcattgttt tagatatagg 20880 agataaaaac atctcataag gcatatattt tagtgaatga gcaagaaaat taccatgtga 20940 aaacataaat gccacttcag aaaagaaaca aaataaggaa atatacaaag aggaatgtta 21000 ttttggaaag agtaatgaag acaaactcta aggggtgaca gtagagcaca gatatacatt 21060 atcatgcatg tggggaagaa tattttaggt agagagaaga gcaagtgaaa agcccttaga 21120 acttgctata tgtgagtaac agcaggatgc tgtggactga gttgggggaa gagatgaggc 21180 tagagagact ggattttaag tgtcattgtt ttaaatgatg gtggaggagt aaagggagcc 21240 acataaactg atttatattt ccaaaatatc acaatggctt cagggtgaag gagatagtgt 21300 agaagccaag agtggacttg gagaaccatt tgagagatgt ccccagtagt tgagatgaga 21360 gatgatagtg actgggatga tggtgacaat ggagaaagtg ccaaaaagca aactgattcc 21420 aggaatattt aagggtagag tcaacagaat gtgccggtgg acttaaaaat ggatgtgaaa 21480 gaaagggaga aatcaagact cctgggcttt ggactaacaa ttggatgaat attgattata 21540 tttattgaga tgaggaaggc tagtgaagtg tcatgttgag ataggagatg ggaaacaaaa 21600 gaggtctgtt tttagatatg taagtctgca atgtatttct gatgtttaga tgagacattg 21660 tataggcaga tagaaatatg agttgatgct caggacagaa attgaagcta gagttacaat 21720 tatggtgtgc aaagccatga ataaggatga gctcatccag ggagtgagcg gaggacgaaa 21780 tttccatgct ggcatggaga gataacaaag aggcctggaa agtcttcaaa tctgcaaaac 21840 agtattgctg ccacccaaac tatcctcttg tgtaagagag atggacacag cactgatgga 21900 atggtgtcaa aggcatcatc acagacttca gtattaaatt gaagttgtca tttgcttgtc 21960 ttccaattat atcgggacac tgggtaaatg tactaatctt tggtgatttg gtgtgtgtgt 22020 gtgtgtgtgg ctgggtgtgc tctgtgtgta tttatgtgaa tacatggact tttaaaatat 22080 ggatgattat gaaatatatt aaaaatgggt aacccatatc cacttgcttt gcattataaa 22140 gctttcttcc tgagaagcta tgctacgaaa cattggggac aacttttttt tttttaaaga 22200 gaaattgaga ctattgtgtc ctggcatcag gccaccatca aaatgagttt gagtttggta 22260 ttacagagga tgagaaattt aatggaaaaa tttaagagga actttgagat gtggaattaa 22320 atcttaataa tgtgatcaag gctggagata tgaatttagg tgtcttccat ttataagtga 22380 gttttgaaac catagaaatg gacatgtttt ccaagagaaa agcatgccca gagacgagag 22440 ggcagggagt aaagctgtgt ccttgtgtaa gggcatggat tcttatttga cagctaaact 22500 tatacaacac agagaaatgt cattccaaga agcttaaagc ttagcatgtg gaagcgtcac 22560 attaaatatt tttccagttc atgaaaaaag ggagtaaatg aagacgtagt tgaaaggaaa 22620 agaactttgc acagaaatct gagaagaaat agttggagat atagcagcag aaccaagtta 22680 gaatgttgtc aaaaaaggca acatggtaga aaactaagaa ttctgaagtt gtttaaaata 22740 ttaaaagaga ggaattcagt tagcaatgag tcaatactca tagtttattg ttgaccttga 22800 tgacagcagt tttaacatga tgcagtagaa tgctaggaaa tgcagaagag tcataaatcc 22860 aaggaacaaa gtgagggtga gtctctgaag gctttctgga agaagtgtta ctaggctaga 22920 gtcttaaatg gctaggagga gtttcccaga aaaagtcgga aggatgaaaa atattaatta 22980 atattttcca atcactgtgt gtcctgttcc ttttgaatta acccctgaca gctctatgga 23040 atgtgattct tattcacaaa tcctatttta tactaactga aaagaatctc acatcaatca 23100 agttctaata atgactatat aattttttga gtaccttcta tgtacctgaa tctgtgcaaa 23160 gtactatggt agatccaaag gtgccagagc actgttctgt tctcaaagtg caaatgctac 23220 atttgcagat caaaaaaaat taaggtccat ttataaagca caggttacat gtctggtcct 23280 atgctctgga ttgcgggcat taagataaaa acataaggca tgtttttgga gaattcacag 23340 tctagtaata tttgatatac atgcaaacag acacagtttc tcatgatcta tgatatgaca 23400 gggtactgtg agaacaaaga ggagggatgc ctaacctagg tcacatgagg ggtcatggaa 23460 agtatagaat gggtaaacct tgagtgcagt cttgcagggg actctatcta ggaagttatc 23520 taggtgaagt tatctaggag aagcagaata tcctgcaagg gttaatgcag agatctgaga 23580 gagtaagttg catttgagca ttcagaataa acacctgaaa agtaaaatat gaaggtgagg 23640 gtgatagaga aaagacttga aagcatgaat tttggctaca aaatgataac ctcagattat 23700 ccagaaaagt gtgactttct aaccttttaa caattccata cttcttagta aaccttccaa 23760 taacatcatc tttattaaca gcttctacaa acccactagc atgatggagt tctgcttcag 23820 cacatctgga tcccaaatgg ttgtcattag tcatttcaaa ggcttagctt attttattta 23880 tgacttgctt caataaacac actattccta catggaattt aatgtgaact tttgacagtg 23940 attactattc aacatttggc ctctaatctc ttctgtgcct cgaagtagtt aacgagcact 24000 cattcaacca gaatttattg agcacttgct acatgtctgg aaccaggaca ggtgccttac 24060 agtggtgctt ctcaacttta ctcttactaa acattaaata tcactcttta aaaaatatca 24120 attgcaattt caaaattagc ttcaatttag aacaacagat atttacagaa gacaatttcg 24180 atatggagat gcttaaaggc ttttcttggc tcatacgacg acaatagaaa gacaaaggtg 24240 cacttgattg cttgttaaaa acttctctat cctaaattta taatgttcat ttaaccaata 24300 tttattgaaa atcagctctg cactgagcac tgatcatttt tgggatactt caatgaatac 24360 aacaaattaa aaaaaaacaa aacctgaaat ggagcttatg ttctaggaag tccagacagt 24420 aatatacaca aacaaaatga ataagctaaa caaagtttac ctttccgttc aagtctaagg 24480 tgctgctgct gctgctgctg aaattcatca tcagtgcaaa taatggtctc aaaacccacg 24540 tgaaagattg caggacaagg gaataaaaaa acttcccttg gaatctttca gtcaaagact 24600 aagcattggt tacttaagct cacaggcaga tatagaggtg gccgtagagg tccctggaat 24660 cagactagct tggttcaagt cttggtcccc ccacttccag gccaggtgac ttcagcaagt 24720 tacctggcct gtctttgtct catctcctca catgaaaaaa gtggcattaa tcttcccatc 24780 atagcattct gtgagaatta agtgagataa tacacataag atactcagag gtgttgagga 24840 tcaagaccgc tgatggcagg tacccgtgtc tgacatagac taaattctca gtagatatca 24900 cttattatta ttgctgagaa gacagtttca ttcatgtgtt taacagaaac tttcagctcc 24960 aatgtgaaga aaatatcttc tgcacacaga gtagatgaga tttgatactt tccctcaaat 25020 cgctttcaag atctttgtcc ttgagagtct catcaatctg agaacacgaa gagatgtttt 25080 agtaccaatt cacagtgttc atagatatat tttggctata aatggtgaag tatgtcataa 25140 taagtaaagc tattggtatt tgtccctaag ctttttgtgt catgtattca aagcttcaaa 25200 atgtatgttt ttatatgctg aacagaactg taaagcataa ttgtgggaag tttggagcaa 25260 atgattgttt taatggcttt cccaaagcag cttatttccc cttgaccact aacaaccata 25320 caattgaaga actttgtgat tggtcttcag atttgcacag agacaggcag tggccatgtt 25380 tttatcttta ctgtgcttgt cttgaatgtc atcagctgac aggaagcata gcaagactga 25440 aggcctcttg tgagttaatg ggcaatttta gttgtcaaag ccaggtagag aataatggaa 25500 ggagttctta aaattaaagt gcgtctgtga gtgtgtgttt aaatgaattg tatttgtttt 25560 gtttttcttg tctttatttc ttttttcttt ttttctaaca gaagaaatcc tgacactcct 25620 gcagaaagct tggctgactc acagtcagaa caggccctct ttattaattt caaattcacc 25680 tcattcactc caggacatag ctttaaagaa aaaaaaaatt agcatttttt tttggtaata 25740 tcctaggtta cagaaagcat caattcttct gcacatagtt aaacacaatt cctcttatca 25800 ctgaaggctt taaaactaaa agctaaagag agtgacaacc atatatttga aaaatgttgt 25860 tgatctcctt tgttacatta ccaatttggc acttaactga aatttctttt aaaatgtata 25920 atccaagcaa tgttttccaa agtagctatt ctatacattt ttataagttt ttctatgttt 25980 tttaaaattt tctatttcat aaaatgtttt cttaagctgt gaattcctgg tactctttag 26040 tccaatattg cctagcttca tgagtaggaa gagccaaatt aatcaaccaa tcacagaaac 26100 aaacaagcaa acaaataata aaaaacattt gtttaaatca tgtacaatat aaatattttt 26160 tacttaacta atttttaagt caagagagct ctgctcaggt ttaaaacata aaactcacag 26220 acaaatttct acactcttct ttacaatgta tacaaaaaac accgactagg aatgcactgg 26280 aggttggcat tggccttgat atttgaccaa aatctgatat ttggcttcta tattagtatt 26340 caaagggctg agtgtctact tcagtataat tttaattttg tgatcagata gattaccatc 26400 gatctagtca caataaaggc atgagtacca ggagcacaga caattttgat tctttaatgc 26460 ctaaatatta tttttcagat ataaaaatat ttacctgtaa cttgaagtga acatttctcg 26520 ccctactttt atacatgaaa aaattgtcta cttggttgaa gagtaaatct atatttacta 26580 ttacaagtag aaaatgctgc aaaaataaat aatgttgatt atgaaaaatg ttaattttat 26640 tttaaaaacc aataaagaat tcaccagtaa agccatctgg tcctgagttt ttctttctga 26700 gaagtttttg gttgttgatt caatctcctt attctctatt ggtctgttca aacattctat 26760 ttattcataa tacaggtatg gtaggttgta agtttctaaa aaatgtattt atttcttcta 26820 gattatgcaa tatgttggca aataattgat cagaataatc acatgatttt tttatttctg 26880 tggaatcagt tgtaatatgt tcttttacag ttttgttttt atttccatct tctggttttt 26940 ttttgtttgt tttctgaaag ctaaaagttt aacagttttg tttatctttg caaaaagcca 27000 acttttagtt ctgttgattt ttttctattg ttttcctatt ctatatttag cttatttctg 27060 ctttaatatt tattatttcc tacatcctac taactttagg cttgctttgt cctccttttt 27120 ccagctcatt gatttgtaaa gttaagttgt ttatttgaaa tttttcttct ttaatataga 27180 tttttatcac tataagcttt tctcttagaa ctgcttttgc tgcacctcat aagttttggt 27240 atgttttcta aatttttata tattatctaa atccccttac aatatattcc ttggcccatt 27300 ggttgtccaa attccacata tttgtgattt tttccttctt tttgtcattt ttagtttggt 27360 atttttagtt cttagtattt tttagtaatt tttttagtat ttttagtttt ttttctgtta 27420 ttcattttta gtttcattca tctctgttgg aaaagatact tggtataatt tcgatcttct 27480 taaatttatt aagacttctg ttgtgacctt atttgtgatc tgccttggag aatgtttcat 27540 gtacatttga aaagaatgta ttctgctctt gtaggcagaa tgttctgttt atgtatgttg 27600 atccatatgg tgtatagtgt tgttctaggg agaattaaca ataatccttc aaaaactctt 27660 ccaaaaaaat taagaagtat aatttccaaa ctaattttat gaggtcagca ttatcctgat 27720 accaaagcaa gacaaagaca ctataagaaa agagaactat aggccaatat ccttgataaa 27780 catagatgca gaaatcttta aaatattagc aaactgggga aaactggcta actatatgca 27840 gaagaatgaa gctggactcc tacctctcaa tatatccaaa aattaactca agatggatta 27900 aagattttag tgttaagacc ttgaactata aacctcctag aagaaaacct aggaaatatt 27960 cttctgtaca ttggcctaag cagggaattt atgaccaagt ccttaaaagc aaatgcaata 28020 aaaacaaaaa ttgacaagtg ggacatagtt aaattaaaaa tcttcttcat aacaaaagaa 28080 agtatcaaca gacaacctac agaatcagag aaaatatttg ccatctgtgt atctgagaag 28140 ggactaatat ccagaatcta taaggacttt aaatcaagac aaaacaaatt acttcactaa 28200 aaagtggtca gagaacatga atacacactt tctaaagaag atatacaagc aaccaatgaa 28260 catatgaaaa attccctgca tcactattgg agacatgcaa atcgaaacca caatgagata 28320 ccatctcaca ccagtcagaa tggctaatac aataaagtaa aaaataacgt gttggtgagg 28380 ttgtggcaaa aagagaacac ttatacactg ttggtgggaa tgtaaactga ttcagccctt 28440 aggaaagcag tttgaagatt tatcaaagaa ctaaaaatac aactgccatt caacccagca 28500 gtcccattac tgggtatata cccaaaagaa aatgaattgc tctaccaaaa agacacatgc 28560 acttatatgt tcattgcagc actatttaca acagcaaaga cataaaatca aactaagtac 28620 ccatcaatgg tggatgggat aaaagaaatg tagtacagac accatggaat attatgcagg 28680 cataaaaaag aatgaaatta tttgctttgc agtaacatgg atgcatctgg tggccattat 28740 cctaagtgaa ttaatgcaga aactgaatac aaaatactgc atattctcac ttataagtga 28800 gggctaaaca ttaggcacac atacacataa aaatgggaaa aatagacact agagacccca 28860 aaaagtaaga gaaagaggga caaggggcaa gggttgaaaa actacctatt agtactatgt 28920 tctctatatg ggtgacggaa tcaatataaa cccaaacctc agcatcatgc aatataccta 28980 tgtaatgaac ctgcacgtat accctgaatc taaaataaaa aatatatatt ttaaaaactg 29040 gcaagataaa tttgataaca cattttttag ttcttcttca aatatttgtg agaattcacc 29100 agtgaagcca tctagtccag ggcttttctt tgttgggaag tttttgattt ctgattaaat 29160 cctgcttgtt ataggtatat ttagattttc tcattttctt gcattagttt tggtagtttg 29220 tgtctttcta ggaatttgtt aatttgatct gcagagtatt ctttcataat cctttcaatt 29280 tctgtaaagt ttgtagtgat gtttctactt tcacatctga ctaagtattt ttgcttcgtg 29340 attaattttt tgttagtcaa tttacttaat gattgactaa ttttattgat cttatcaaag 29400 atccaacttt tggttgtact gattctctct attgtttttc tatgaactat tttgaatgtg 29460 gctttctaag attaactgta ttcagtgctt ttggatgttg taatttccta cagaaactct 29520 ttcccagctt tgcttcccag gctttaggga gtcttttgta catcacaact acaatctttt 29580 gccccagata actgggcttt tgattcatca tcaaatgttt ttgagcaatg ccttctcctt 29640 tttctccttg agttctgagt taggtgaaag agagataagc atcttccgca gtccttcatg 29700 tagcctctag actagttaga acagacaaac acacgaattt tcaaataaag tctgctcagc 29760 tccattaaga accagggaca aggactgcac tggaaatgca gggtgtcact ttcaagtctg 29820 cagcagaact aggaagggta gccaagggca actgaaaatg ccacaaactt tttctactat 29880 ttttatgttg cttttttctt gattcaacat tcacttactt cctgtatgct tttgaccatt 29940 ttctggggct gtgacaaagc ggtttcttat aattctgctt gctttttgat gtttttgtgg 30000 aggaacaggt gtttcgagcc acttgctcca tcagtttgct tacctcacct atccaaattt 30060 atttttgatc ccagaattta attctatgat agtgattatc agttttggcc tcaactttca 30120 gccactttat aaaattgggc cttttgacat ttggccaaaa tgtgtattca tttcacctta 30180 ttattgaaat gggaggaatt ttcccttatc cccctagcat ggccagcgac agggacgggg 30240 gtgtggctga gttcttcagt gccccacagc tcgaaaccct agggggacca ggcagacggg 30300 caggccatgg ggagcatttt tgggcttcga ctctatggcg atgtctaggg ttgagagttt 30360 acagctccca aagccccagt gggtgtgtat tacagtgtgc tctttcagtt ttgccgtcca 30420 caggtggctt gtgttaaaca gctcagttag accctcgctt tatcgcaagg acagagggat 30480 ttctgtatct tgggtgcttg ccttagtgta ccgaaaaaat cagatcacgc ttgggcttgg 30540 aggatgggtg caaggtttta ttgagtgctg gaagtagctc tcagcagatg gatggggagc 30600 cagaaggggg atggcgtggg aagatggtcc ttccgtggag tctggcctct cagcagccag 30660 gctcttctcc aaccgcctgc ccttggccga attcccctct gcattcgcgt cgttctgccc 30720 tccatggcct gcgagcgtct gttggtgggt gtgtttctct ggaaatccag ccacttgtac 30780 gtgcccgcta gggcctcggg gtttttatag gcacaggatg agggggtgtg gcaggccaaa 30840 gtggtcttgg caaatgcaac atttgggaac gaaaacagga gtgcctgtcc tcacttaggt 30900 ctgtgggcac aggcccaagg atggatcccg tggcagggac cccattcttg tctccccagc 30960 actttcctgc agccctccca tatctttagg aactttggaa aatgttcagt cttgtcacaa 31020 tcttgattta ttccttcttc ttccaaaaca taaatatgag gagtattaat gaggttgtct 31080 aatttacgtt ttggagaaat taatggattc ttggcttggc tatctgcagt atttactcat 31140 gtctgaacct taagcaaacc tgctttcaca tttatgtctt gatctgtagt ctaacacttg 31200 actcaattta ataatgccca aaagaagatt aaaatgctct ttatttgata aaatagtaat 31260 ttctagcata atgatttcaa gacaaaattt ttaaaaatgg aagtggtaac aaaaataacc 31320 ttgttgagtt caaacccgat atagtttcta agaccaacaa acaaaaaata gtttttaaac 31380 ttcttcattt ttaaaaatag aaagcttatt tacatttata atataagaaa cattcttgaa 31440 ctgaagtgta atgcaaatag gaacagtggt tatgttttag aggatgctgt cacttgagta 31500 gtttcaccca tcagacaaag aaacaaggat ggcagaaaac acagcaccct tttcatgtgt 31560 aaaatgtgac ttgtcacctg tcaaactctg aatgataatc tggaactcaa ctagttggca 31620 atttgaaaag tacacacaaa tatttatcca atatggcaca caaaacaact accattttgg 31680 agagccttga ggcagtatct cattaatttt aagatgtgca tacattacta tctagaaatg 31740 cccacagtta ggtagctacc ttagaaaaat tttcaaatac ttgtcacaag gacacatgta 31800 acacaatgtt cttttcagaa ttctataaca caaaataatc atagaaaatc aaaattatta 31860 caattagaga aaaaaaatta aatggttgct cttctttcca tccatgagtt taaaataata 31920 tatcaaatta ataagcatag ataaatgaat gagatctaca tgtattaaca ttgatataaa 31980 cattacactg agtgaaaagt tgtagaaaga tacatttcat cagttacata tatttgagaa 32040 acacaggaaa tactatatat tccctcaaat gtttttgagc aatgccttct cctttttctc 32100 cttgattgag ttctgagtta ggtgaaacag agataagcca tcacttcttt tttcatccta 32160 gggtgaaatt tgatatcacc ctatgatatt tgttatttga acaataagaa tattttttca 32220 taagtatttt ctttagttgt ccccaaataa gttaatatta caaatataga ataggcttgt 32280 ttacattaaa aacacccttc tccatcaaag aaattgtgat ggttgtactg ccctttcacc 32340 ccttaggtgg ttgcactgcc ctttcacccc tccttcctac tcccaccctg gataagccac 32400 agctccgggg cacgtgagag taatttctta taagatttct ctgtgataga cttcagaaga 32460 caagttatat actcatgaga ttctgaaatt gtaaaatatt agtgccaaaa atccctcaag 32520 aactgaatta tcttttacaa cacctcaatg aaaagactaa gaactgaagg ttagtggggt 32580 gtattcacct ttctagggtc acataatgaa gcagggcatg taatacacag caataaagga 32640 gaagaaaggg attaaatgct gaagtaagtg gtgaggttaa caattctaaa aaaggcagaa 32700 acaaaattga tttgagttgt ttaaaggtta cttaacattt catgtaaact ttcatagtac 32760 agaaaactat aggaaagcat tccaaatttg cggaccacag tctgataaaa gaaatgaata 32820 gcttattctt aaacaagatc tgtttggccc atctaggaag ttatgctggg aaagacatga 32880 aattaacacg cattaagaga tagaccctct atctgtgcaa tgtttcttct ctcataatta 32940 agaaaaatcc actgaattca tgccaggaag tctgtctgac cctgatgcct accttactgt 33000 caccataaaa cactgtcttc caggatgttg gggaatggag agattgaatg ggtgtacatt 33060 ttgggaaaaa aaacttcaaa ggcaaatatt ttgtgtgcgg ctttaatgct aagaccagca 33120 attagctatt gaggataatt ataccatggg gctaacttct atgacattta aattcgtttt 33180 cattgtgaat catttcagcc atataaaaaa gaatagcaat ataaaaaata atccatgtgt 33240 ttactaatat gatttatgaa atgttgacat tttgctgtat ttgtttcatg ttgtttttgt 33300 ttatcttaga agttttagat aagataaaag ctcctcctct ttttgttccc catctttcag 33360 tcccagaagt aaccatttcc tgaagcaact attttggtgt gtggcctcct gaagctactt 33420 cattctttac aacatgtcta ccctatatat tcttatgtgt ataaagccta tataatattt 33480 cctgtgtttc tcaaatatat gtaactgata aaatatatcc ttttgcaact tttcaatgta 33540 atggttatat caatgttggt acatgtagct ctcattcatt tatctatgct tattaatttg 33600 atgtattatt ttaaactagt tgattgaagg aatagcaagc atttaatttt tttctctaat 33660 tgtaataatt ttgtttttct atgatttttt tattatagaa ttctgaaaag aacattgtgt 33720 tacatgtgtc cttgtgacaa atttttctaa ggtagctacc taattgtgga catttctaga 33780 tagtaatgta tgaacatctt aaaattaatg agatactgcc tcaaggctct ccaaaatggt 33840 agttgttttg tgtgccatat tggataaata tttgtgtgta cttttcaaat tgccaactag 33900 ttgagttcca gattatcatt cagagtctga caggtaacaa gtcacatttt acacatgaaa 33960 agggtgctgt gttctctgcc atatttgttt tttttctttg tctgatgggt gaaactactc 34020 aagtcacagc atcttctaaa gtatacccac tgttcctatt tgctattttt tgctttttgt 34080 gatacaaaaa gaaggggtag gaatttgcta catgaccttg ttccatgcat atttgctaca 34140 tgagtcacat gtacacctgt gacctcctgc aagaatgcaa tcagtaccag agaaagaatt 34200 tgccctcaaa cctcctccat gagctgataa agattcctga gtcctactga ctgcttgaat 34260 tgtctaatgg ataagatgta gagtcttttt agtggactaa ttggtatcct gtcacatgtt 34320 aaagataccc aaaaatatga attgtccaaa tatactagaa gtcatttagt cattgaaggt 34380 ttaccaccca gaggccaaaa tccattcaag cgtcaaacaa ctgtgtctca ctccttcaat 34440 tttaccctga tggaaaatgg atcctgctga tggttatctg aggcaaactc tatcatgact 34500 ggttaataat aatcatattt cttcttggta tacctttacc aaccaattaa gcccttttct 34560 gtcagcgaag aaagctgaac tgtgtctttc atttgaacca catagcccag gaggtgcaaa 34620 tcttctcctc tgtcactaga ctctgagatc tctaagtgat atggacaatg aagacctatg 34680 catgtgatct ttccagtcaa tctcaagagc tagaatcaag ttctgccata cctagccact 34740 ttgtgtcagt atgaaaaagg tgtttcttcc atgtgaaagg agcgctgttc agggtgtatt 34800 agttagaggg aagagcccag gctgggattg ggcccactaa gccccttatc agggcagccc 34860 attgcagtca acacccgata tggccataag ctgcagctgt ctgctaacag ttggctccct 34920 ttgttattgt gctgttccag agagggattt gggaaagggc agtaagagac acaaactcag 34980 attttcatct tctcacaatc ctctccaaca tgtttacatt gtttatagat aattttaatt 35040 aaaggggatt acaatgcaga taaagtaatt ttatatccta ttttgtaggg ttgtattgta 35100 ttggttccat tttctgatgt cattaaattt caataaatgc aaatcttgca tattttattg 35160 tatgaataga tattgatcat aagacttatg tgactagagc tctgttttaa agacttttat 35220 ttccagtaat ttttagctta gtacataatg ctctgataaa cttttttatg catacatttt 35280 ggtctgcttt tcagactact ctctcattct ttcattttgc acatatatat tttgtgtgtt 35340 ttatgggaca gaaactgttt ctagcacttt tgatacacca ataatgaaga attaaaagga 35400 aatatgggac tctagaaatc taaataattt aatgttcttt acaaatattg gcagatttgc 35460 acctatgatt ttaaagttag agatggtctt caagcactac acattttgaa gccttgagat 35520 taatcactga ttgttggagg tgggatccca agacctgtct cttctttgct ctacaataca 35580 aaatattaga agttactttc aaaaaactat tcgtcaaagg aaggtagcaa tatcagcttt 35640 attgagatca aatgactgca gagcacgatt tccacctgag atccacactg ctggttctag 35700 tttctcccca ctgacaagaa agacctttga agaagcagct gaagaagcta ccagaaggca 35760 cagatcctgg taatattcct gtgctagcca gaagctcaga aggcccaagc ttcactcatc 35820 cataaaacag gcaacataac agaagacgca gcttgttcct tacacagaaa tcctatgcac 35880 cctcaccagg ttccaggatt tatctcgctc tttccagtca aattatctat agctccttcc 35940 agcttcctcc attcagagaa agaataggcg gcctatcttc agaaggaatg tgaggaggag 36000 tatttaagaa aagttagtcc tttggagaat attgaatgaa agttataggg agcaatatgg 36060 cttcccagaa ggggtaaggc aatagggctc tgattcctgg acacttacta tctatctaac 36120 cttgaaaaaa ttactcaaat tatcagaact tagagagtga gaaataagac actcatttca 36180 tagtgttgca tgaattaaaa gagataatat tgttgagtaa ttttacctcc ctacgaagtt 36240 gccaattcat tgacagagag aaaactaaac acacacacac acaaaacaac aacaaaaata 36300 gttgtttgat acgttacctc attgaatgtt atagccatat aggtcaatgg ttaaattaga 36360 gatgctttgt atatattctc attactaaga cagtttacta gatcttatgg ctcccatagt 36420 cccaatatac ataaatcagt cacacataat tgtccacata tgctccacat tattacacta 36480 acatgagctt gcttatttta tttgtatgtg atattaacag atttgtttct tacttgatag 36540 gccttgaaga tgacttagtt gttgagttca gtacctgtgt ctgttctacc gtgcactgaa 36600 tgttactgac ttgtacagaa atcatgctca aggtttggtg tccacactga ttgtctctag 36660 aagattaaaa tatatataaa tgacttatct atatttacta cttttattta tggaaaaatt 36720 aaattcttta tagagtctta tggaagcttg ctctgataaa atttttccat aactgtcaaa 36780 gtggaaagta tgacgagttc aggattagat tagaatccta atggtattat ggccaggaac 36840 ccaaatattt ctgaatcctt cctgggatat cacctttttt aaccatagga taccagagag 36900 agttgcaaaa cagaaaaaaa ataataatgg cataagtagg aatttggaat gtagtttatg 36960 tgcagatttc tgtcaaaagg ctaagtggac gctcatgtct tagcctagaa gcttcattga 37020 tgcctccaaa tctcctatcc caggatccta aaatctggca tgctgcaaga aacaagacac 37080 tgaaaaaggc ttggagtcta cagaaaaacc ttatgaatcc acacaactac ttctgatgga 37140 aaataagaca agacagagat tcactaagcc cacctgagtt gtcaagcatc acataccaaa 37200 gaaaggcaga aactggaagg caccaaaaag actgtaaaaa gcatttggtt tctgactgta 37260 agacattgag acactcattt gttaggagca actcctcagc tcttggcgag cagtggggat 37320 gaaagcccag aaaggtagaa gctcgctggt ttgtggatag ggttagaagt gttaaccttt 37380 ccctatattt ccctctcctt aggcaccttt taagcgatta gacttaaaaa aaaaaagttc 37440 agtgaaaggg caagcagaga ggtgggaccc accttaggat aggaaagaaa tagtcaaagc 37500 tgctctctcc ctcctgctgt aagctacttt ctggggccct ctttggcatc ttggaagact 37560 aagatgggta agttgtttct ctaagaatcc acgaaataga tcagaacttg aagttaattc 37620 caaagaggca atgcacatta ggatgaacaa ctattcctct tgaatttctc aactcatgtt 37680 ataccttgtt atgtccttta ccctagttta ccagaagggc acattaggag tacatatatt 37740 ataaaaccat gatacaatta aaatgacatg gagtcaaaca aggaaactgt ctttcttcca 37800 gagaaattac atttcaaatt gaaatttcag aggtgacatg aatggaaata ttgtaaaagt 37860 gatattgcta tcgtcttttg gccatcagtt ttctgaatat gccttctaat atttagatcc 37920 ctggagtgaa agaggggaag tcttgggaac tcaaactcca ataaattaga ggtcaattat 37980 aaggccatat aaatgtttgg tgcttaaaga gcacctcact aaaaaatgat aggagcaggc 38040 cagatgtagt gctcacgcct gtaatcccag cactttggga gaccaaggca ggcggatcac 38100 ttgaggtcag gagttcgaga ccatcctggc caatatggtg aaactctgtc tttactaaaa 38160 atacaaaaat tagctgagcc tgttgatggg tacctgtaat cccagctact tggggggctg 38220 aggcaggaga actgcttgaa tctaggaggc agaggttaca gtgagccgag atcgcatcac 38280 tacactcctg cccaacaacg aagcaagact ccatctcaaa aacaaaacaa aacaaaacaa 38340 aacaaaacaa aacaaaaaat ctggtgtaaa atacctccaa aaagctgctc ctttataaag 38400 gcaatgagta cactggaaaa gtagtaaata aactttttca gaactcaaac taagcaaaag 38460 cttgcaaaca aaaaaatgaa gttcttattt aaaaaaatag actgaatctc agtaaaaggg 38520 aactttgtga tgttttacct tatactattc tcagttccct ccctttcaga cccagaatag 38580 ctgttacaga ttgaattaag tggttttccc caccacaatt catatgttaa accctaattc 38640 ttaatatgat tgtatttgaa gatactgcct ttgaggaggt gactaaggct aaatgatgtc 38700 ttaagtatag ggcaccaatc caatagaact agtggtcttt taagaagaga aagaggtacc 38760 agagctctct cttcctctgt gtgtacagag aggaaaggcc atgcaaggac atagcaaaaa 38820 ggcagccatc tacaagccag gaagagaggt cttaccagaa accatccctg atgataactt 38880 gatcttggac tttttgtctc cagaaccttg agaaaataaa tgcatgttgt ttaagctatt 38940 cagcctatgg tactttttaa tggaagcctg aataaatgaa tacagaagcc tttaaaacca 39000 acagacttat aaggcagagt tgtaagctgc ctgcctcagt attgaagtca taccccaaca 39060 tggacacaaa cactaccgtc aaaggcagca atgcttatta atcctaaaca tttaagaaaa 39120 tctttggctg gtcagcagtt gaccactaag ataactgggc aaaaactttg gtgaccatac 39180 aaagaaaata aaaaatttac agaattcttt cctgacaagc aaacaataac agcaacaagc 39240 agcaacatca aactcagtgt ggggaatgga aactgacttt cagagtttcc atattatatt 39300 attttaaatg tccagttttc aacacaaatt atgaaatgta cacattaaca agaaagtgtg 39360 ccttatatga ggaaaaaaaa atcagtcaat agtgtccctg aagatcccag acactggact 39420 tgttagaaag catttaaatc aactgtttta aatatgttct aagaactgaa taaaaacaat 39480 catttctaag aaaatctagg aaaatatgag aacaatattg caccaaataa agaatatcag 39540 taaattaata taaataataa aaaagaaacc aatagaaatt ctgtaatgtg cagtaattga 39600 aataaaaact tccccagagg agctcaacac agattagact tagcagaaga acaaataact 39660 aaatatgaag atagatcagt tgagattgtc catgtgagga acagaaagaa aaacaagcaa 39720 ataaacataa acagagctag acatctgtag tacgccccca atcacacaaa catatgcatc 39780 atgagagttt cagaagagaa aaaagaaaga ggtagagaga atatttgaaa ataactgatg 39840 tccctaattt ttccaaacat taatcttcac agccaagaag ctcaacaaac tctaagttgg 39900 ataagttcaa agagagactc ttcaaagcag caagggaaag caattgataa gataccatta 39960 ataatattaa tagacattct cagaaaccat agaggcaaga atagagtaga atgacatgtt 40020 caaagagcta aacaaaatta atctcaatca gtatttccat atttcagcaa aagtatccat 40080 caaaaatgaa aaaaaaaatt attatcagta aacaaaaatt gagataaact gttgccagaa 40140 aatgtattct aaaggaaaca ttaaagagaa tccttcaggc tgaaatgaaa cactaaacag 40200 taagttgaat ccatgtgaca aaataaataa caccaatata aataagtgca caggtaaatg 40260 taaaatacag tatcaatgta ttttacattt acaagtcatt tttcccttct attttatttt 40320 caaaaaattg tataaagcaa taattctaca ttgtgtttat aggcatatga tgaataaaga 40380 cacaacttgt atgataatta cagcacagag aaggaggaag aaaatgaagt tatataagag 40440 ccaggttttt gtatatgaat gaagtcagtg ttcatctgaa ctaaattgtt gcaaattaac 40500 gtgttaattg taatccccag ggaaaccact gaaaaaataa caaaaataaa cagtaaaata 40560 aattacaatt tattggttag agctacagag aaaaaaaaga aatgatagtg atattaaaat 40620 actacagaga caaatatcta tttaacagaa aagacagtaa taaagaaaag gaagaagaaa 40680 aaataagaca tttgacaaat aaatatcaaa ttggtatata aaggagaatt ttcagtaact 40740 gtattaaata aaaatgggtt aaatactcca accaaaaggg attgacaaaa tattaaaaca 40800 aaaacaaacc atagtccaca acatgctgca tacaaaatac tttagattaa aagatacaaa 40860 taggttaata gtaaaaatat ggagaaagat atactaaacg aacagtaacc acagagctgg 40920 aatggctatg ttactcacag acaaaacaga ttttgggata aacattacca aatacaaaga 40980 acattatata ttaaaaaagc atcaatccat cagaaatata taacaattat aaacatacat 41040 gcccataaca aagggtccga aaatacactt agcaaagcat gacagaattg aaggaataaa 41100 tagacattca acaataatac ttggagagtt gaattctcac tttcagtaat ggctagacag 41160 caggttagta aatcaacaag ggagaagaag gtttgaaaaa cattattaag caattggacc 41220 taacatacgt ctacagaagc ctccaactaa caacagcaaa tgattttttc tcagttgcac 41280 attaatattc tccatgatag accttatgtt agaacacaaa acaagtctta ataaatttta 41340 aataatttat actacacaaa tatattctcc caccgtagtg gaatataatt actaattatt 41400 aataaatgga aaattggtaa attgccaaac atgcagaaat ttaaaaatat atttctaaat 41460 aaccattgtg tcaaggaaga aatcacaagg ggaattagga aattattgga gatgaaaaac 41520 acaacatata atttatggta ggcagctaaa gctgtacata gagaaacact tataactaag 41580 tatctataat taatagtaac tgaaatcaat aacataattg ttcacctttc aaaactaaaa 41640 aactagaaac aacttaacaa cccttgctaa caaccttaag caagcagaaa gaagaaaata 41700 ataagcgtat gagagaaaaa ggaatgaaat agagaataga aaaacaatgg aaaaataaaa 41760 aaaccagaat ttagttcttc aaaaatataa acaaaattga taaatgttta gctgggttag 41820 attaagaaca aaaagagatt aaccatgtag ctggatcaga ttaagaacaa gaagagatta 41880 aagttaataa aacttggact aaaagaagga atattactgc tgattaggaa aacaaaaatg 41940 ataatatgac atactataaa taattatatg cctactgatt agataatgtg tatgcactga 42000 aaagattcct agaaaaacaa accactaaaa ttaaattatg gaagaaaaac atctgtatag 42060 acttttaaca agaaaatatg tagaattagt attaaaaaaa aacctttcct cgaagaaaag 42120 cctggtccac atgattttac tgatgaattc tatcaaattc ttaaagaata agcatcaata 42180 atcttcaaac tacttcaaaa tatagaaaat cttcttattt tattctatga ggctagtatt 42240 atcctgacat aaaaaccata caaagtcatc acaataaaat taaactatac attagtatcc 42300 cttttgaata ctgacacaaa cattctgaca gaatacttgc aaactgaatc cagcaacata 42360 gaaaaaaagg attatacaat attaccaagt tgggcttatg ccaggaatgc agggttggct 42420 cattctatga aaatcaatgc aggtaatata acatacaacc aggctaagga acaaaaacca 42480 tatgattatt tcaactgatg cagaaaaagt actcaacaaa atctaacact cttatatgat 42540 taaaatataa aaataaaaaa cactaaacaa tctagagata caagtaatgt ctttaacatg 42600 ttaaagggct tttgtgagaa gcccataatt aatgtcaggc ttcttgaaga ctgagtcctt 42660 ttcttcctaa gatcaagaat cagacaaaga tgcctgcaat gtctgctcct gctatttcca 42720 tttaatgttg aagtgtatgc tcaggccatg acaattaggc caaaaaaata aaaaaagaaa 42780 aagaaaaaaa agagaggaga ggagaggagg ggggagggga aaggaggacc agggagggga 42840 ggggaggtgg ggagagggga gggcagggga ggagagaggg gaaaggaaga gaggggaaag 42900 gaaggaagaa aggaaggaag gaaaaggaag gaaggaggga aggaaggaag gggaaggaaa 42960 ggaaaaggaa ggaaggggaa ggaaggaaga ggaaggaagg aagaaagaag gaaagaaaga 43020 agaaaaagga aggaggaagg aagaaaaagg aaggaagaaa gaaggaaaga aagaacgaag 43080 aggaaggaaa agaaaggaag gaaggaagag gaagttaaag aaaaagaaag aaaggaagga 43140 agaaagaaag taagagaaag taaaagtaag aaagagaaag gaaggaagaa agaaagtaag 43200 agaaagtaaa agtaagaaag agaaaggaag gaagaaaggg aaaggaagaa agaaaggaaa 43260 gaagaaagga aggaagaagg aaggaaggaa agaaagaaag aaagagaaag aaagaggaag 43320 gaagggaagg agggagggaa aggaagaaag gaaagaaaaa aagaaagaaa aaaaggaagg 43380 aagggaaagg gagaaagaaa ggaatgaaga aggaacaaag gaaagaaaga aagagaaaga 43440 aagaaaggga aggaaagaag ggagggaaag gaagaaagaa agaaagaaag aaaagaaaga 43500 aaggaaaagg aaggaaggga tggatggagg gagggaggga ggaaggaagg aaggaaagga 43560 gggagggagg gaaaggaaga aaggaaggag gaaaggaaga aagaagaaag gaaggaaaga 43620 aagaaagaga agaaaagaaa agaaaaaaga aaggaagaaa ggaagagcgt ccaaattaaa 43680 aataacattt aaaataatat ctatttgtag ggtacatgat ttgcataaag aaaatccaaa 43740 ataacttaca agagagctaa caaattaatt cagccaggtt gcaggataca atatcaacgt 43800 aaaaaaactt aattgtgttt ctacactatc atgaaacatt tgagaaatta aggaaatgat 43860 tacatttgca gtagcagcca aatagatccc ttagtaaatt gtgcttaggc agctggatat 43920 tcacttgcaa aagaattcag ttggattttc atctcacatt atgtacaaaa ataaacttaa 43980 aattgactaa aatatctaaa cataaaagct aaaactataa acatctttaa aaaacagaac 44040 cgacccaaat gtccatcaat gatagactat attaagaaaa tgtggcacat atacaccatg 44100 gaatactatg cagccataaa aaatgatgag tgcatgtcct ttgtagggac atggatgaag 44160 ctggaaacca tcattctgag caaactatca caaagacaga aaaccaaaca ccacatgttc 44220 tcactcacag gtgggaattg aacaatgaga acacttggac gaaggttggg gaacatcaca 44280 caccaggacc tgtcatgggg tgggggaagg gggagggcta atattaggag aaatacctaa 44340 tataaatgac gagttaatgg gtgcagcaca ccaacatggc acatgtatac atatgtaaca 44400 aatctgcatg ttgtgcacat gtaccctaga gcttaaagta ttaaaaaaag aaggggggaa 44460 aaattcatga ccctgacttt gacaaagttt tcatagatat gataccagaa atacaaggaa 44520 caaaagaaaa aaaatagata tgttgtgctt catcaaaatt taaaactttt gtaaataaaa 44580 agtcattaac aagagaataa aaaggcaatt caaaacatgg gaaaatatat ttgcaaatta 44640 tatatctaat aatggactag catccagaat ctataaagaa atcttaggac tcaacaaaaa 44700 gagataaaca accaaattaa aaatggacaa aggctagaat gaatgttttt caaaataaga 44760 ggtaatgaat gtcccacaaa caaattaaat gatgttcaac atccttagtc attagggaaa 44820 tgcaaatagg gaccacaata aaatgccact tcacacttgc taggttgctc agaatcaaaa 44880 caatgaaaat ataatgcata tgatcaagca tgttgaaaag tcaaaaccct tgttccttgc 44940 tggtaagaat gtaaaactgt gcagccactc tctctggata acagtttggt agttcctcaa 45000 aagttcaaac ataattttcg tattacccag caattccact tctaggtaca taccaaaaag 45060 aatttaaaat agttacggaa atgcaattgc atatattttc atagcagcat tattcacaat 45120 ggataaacga tgaaaatgcc caaatgccca tcaactgatg aatgaataaa atgtggtata 45180 ttcacacagt ggaaagttat ttagccataa aaatgaaggg agtactgata acgtgctata 45240 acataaacaa gccttgcaaa aattgtgtta actgaaagca gacctacaca aaatatgatt 45300 ccacttgtat gaaatgacca gaataggcaa atgtatagag ataaagagca agtagctaat 45360 gtctgtggat cggcagagtg gcgagtgatt gtttaataag tgtgggtttc gtttttggag 45420 tgatgaaaga gttttgaaac aatgctgttg agggtcacaa aacattttga atatactaaa 45480 aaaccctgaa ttttacacct tgaaatgtat aatatataat ttttttccca atgagaagaa 45540 ataaaaattt gaaaacatca acaaaaaatt cctgactatt gctaccaaca atagcaataa 45600 attttcagct ataaatttac caaaagaaaa tagaaacact aaattagtag aaagaaaaat 45660 taaaatgagg aaaacagtca accaagttct cttagtgctt tggaattacc taggaaagta 45720 aaggaaagag atgcctaaat tttaaccttg tatgtggtta cacttttctg tcattggagt 45780 ttagatggca ctggtaagta aatcaattgg gcatattgat atgaactcca aaatatttaa 45840 agccaacttt cgataaaagg gtaaaatcag agcattaata cagatatgga cattttaagg 45900 gaacatgaat attgatcaaa atattaactg aatatataag taggggaaat tgattttgtt 45960 acactgtgag gagggtggac aattgaatct ccactggaca aaacattgtc tgtcagtgac 46020 ctatgactta tagcatataa aggaactcaa agacaatgaa agtctagtat caggtaacct 46080 gaagtggtgt cctctagacc agataaattt ttctattggg acttcttttt ttctacacta 46140 ttctacaaca tcaaatagaa agttagactt ctttctaaaa gagggttcag ccattagagt 46200 gacaaagtgc ctatcacaaa catttctagc cccaggcctg atcaggggcc accaatgaca 46260 ttcctaaatc taggtgtcag aaagcctact ccctaaccaa tgaggggctg acacatggag 46320 atacaattgt taagacagaa ctggcatatt gagaagcccg gggcaactga aaaatcaaag 46380 tgggacaatt ggagcaaaga ccatattaga gagaaggagc catcagagtt tctagaggag 46440 tggaaattaa atctgcttct acttcataag agatgatctg taagttccta gtgagccaca 46500 tggcctgcct cctgaagaag aatcattatg cctagcactt gagctcccag gagggttttt 46560 cttgctgcca atctcaagca aatgaagcca ctatcctgga tttggcaaga atggaagctc 46620 acaacccctg cagcaggatg tgtagacatg acagtgcaaa ataatccgaa gattggctgc 46680 ctcttgaggg atataaccat ttctctggtt aatgaacttc tgatccagga aaagtttctg 46740 atttctgggt cctggagctt tgggggaggc ctcacagact catccagtaa gtactgtcaa 46800 agagtttaaa tatatgggct tgcttctgac tcctcacaat tctagtcttc tttaattgga 46860 agtatctatg agacatctgt attagtccgt tctcacactg ctgtgaaaaa atacaagaga 46920 ctgggtaatt tataaagaaa agaggtttaa ttgactcaca gtttcacatg tctagggagg 46980 cctcacaaaa ctttcaatca tggtggaagg cacctcttca cagagtggca ggagagagaa 47040 ttgcagagca aagggggaaa agccccttat aaaaccatca gatcttgtaa gaactcactc 47100 actttcatga gaacagcata agggaaccac ctccatgatc taatcacctc ccacgaggtc 47160 actcccgcaa ctcttgggga ttacaattca agatgagatt tgggtgggga cacagccaaa 47220 ccaacatcca agcaaagata tcccaaagag atctggaggg ttagaaggtg gtggtcctgt 47280 gaggtgttcg aatcagtaat gtcagaaagg aacagtttct tatggtgaca cttgaggaag 47340 tggccttagg taggaatgtc tggctgaggt gtcaggataa agaagaccac ctcattggcc 47400 ctgaggaagc caaggtcttg tgaggccagg atgttggctg gaggcctctg gggtgtgttg 47460 aatttcctag agtgatggta gtaactgagg tagaactgga gatcttggtg gacttgctaa 47520 caactttatt tagtatagag aatatctaca ggtaagaagg tgttggcaat ggggatgagg 47580 tggagaaggc agcatcgcag ttggcatgga cttaaatggg gcaggggttt ttacatgaag 47640 attgaagggt gataagtgaa acaaaaaaga aatacataga aaagaaagaa aaggaattga 47700 ttccaaatac atattataac atacgtgtta cggactgaac tgaactgggt atactttgtt 47760 atggcaacct tgctaactca cacagattct ggtatcaaaa gggaggattc tgctgtaaca 47820 aataaccaaa aatctagaag tggctttgga actgggtaga gaaatccatc tcatttggat 47880 gtatgttaca caaagcctaa attgattgga agagagtatt gttaaaaata tagatgctga 47940 atgtgattcc cgtgagtcct cagaaaatta gagagctgta gagaaatctt ctagcatctc 48000 ataaaaatac atgtacagtc attaacaaaa tgttgctaga aatatgtatg ctgaaggtgc 48060 ttctggtgag gtctcagagc ttaggaatat gtaattgaaa actggaggaa aggagattct 48120 tcttacaagg tggcaaggac ttggctgaat tgtattctag tgttttgtgg aaaatagatc 48180 ttgtaggtga tgatcttgaa taattcactg aggggatttc taggcaaaat gttgaaggca 48240 taacttgatt tctcttcgct tgtatggtaa aatgtaaaag gagagataga ttgaagaatt 48300 gtcagcaaaa agataccaga gcttgaagat ttgagaaaat ctcagcctat caatattgca 48360 gaaaataaga aattgtgtcc tgaaaaatat caaggatagg gctggataat gatttgccaa 48420 aaaaataatt ataggtgtgt gacttatgat tccaatcagc tgtctcagct gaaaccatga 48480 atggagatgg ggatttatac cagtagaagc actgtcaggt tgactgaagg agagaaagat 48540 gaaatgaaat gaagcaaggc tgttggactc ctgggatttt atagcatggg ctaatacaga 48600 cacgtggttg tgaacatatg ctatctttca tgaaaaagga atggctgtga aggcagttca 48660 gaggttgttg gggctgccac tgtcaacgtg gatcctcagg tctgagagtt ttggggtagt 48720 gccaccacac tggtgggccc aaaaggcagc gttaggacta ggatgggctc tgaggacaca 48780 gcatggagtc aaagaggatt attctcaagc ttcaaaatcc tatggaattt tccttgctag 48840 gtttcagact tgcttgcaac ctgttacccc tttattcttc ccaattgctc ccttttgcaa 48900 tgggaatgtt tacctcatgc ctattgctct aagatgaatt ttgtctcccc aaaatccata 48960 catcaaaacc ctaaccccca ggatctcgga atgtgactgt atttggagat aggtacttta 49020 aagaggttat taagttaaaa agacagttaa gatgagccct catccaatct tactagtgtc 49080 cctgtaagaa caagaagcga gccaggtgca gtggctcatg catgtaatcc cagcactttg 49140 ggaggccgag gcaggcggat cacaaggtca ggagattgag accaccctgg ccaacagggt 49200 gaaaccccat ctctaccgaa aatgcaaaaa ttagctgggt gtggtggtgc gtgcctgtaa 49260 tcccagctaa tcaggaggct aaggcaggag aattgcttga accagggagt cagaggttgc 49320 agtgagccga gatggtgcca ctgcactcta gcctggtaac acagcaagac tctggcaaaa 49380 aagaaaagaa caagaagctt ggagacacag gaaggtacca gagatgtgca agctcagaga 49440 aaagaccata taagaacaca acaagaaggc ggccacctgc aagccaaggc aagaggcctc 49500 agaagaaacc aaatctgcaa aaacctcgat cttggacttc tagcctcaag aactaaaaaa 49560 gaaaataaat ttctgttatt taatgttatt taagtcaccc agtctgtggt attttgttat 49620 ggtaccccta gcaaactaat acacctacca ttctatttta gaagtagata actcatcaat 49680 ttcacaggat cacagctgga gagcaatttt gccccaggaa tcatgactca agtctcattc 49740 atacctgatt tagacagtat ttatatgaga ttttggactg agatttgatg ttgcaatgag 49800 ttgacttttg gggctgttgg gatggtgtga aagtattttg tatatgagaa gacaatgaat 49860 ttgcagagtg gcagggggtg aagtattatg gacagaattg tgttctcctc aaattcgtat 49920 gctaaaattc taaccccagt accttagaat gtgactgaat ttggaaatag ggattttaaa 49980 gaggtaatta agttaaaatg gggctgtgtg gacactaatc caatattact tgaatcctca 50040 taagaagaag agaatagaaa cacacagaga gaagaccatg tatggagacc agaaaaagat 50100 ggctatctcc aagccaagga gagaggcctc aggagaaaca accctgctga caccttcttc 50160 ttagactacc agcctcctaa atggtgagaa aacaaatttc tgttgtttag gtcatccagt 50220 cttcagtact ctgttgtggc agtttaagca aatgagtaca atgggtgaat cttgaaaaca 50280 ttatgctaaa taaaagaagt catatgcaaa agaccacata ctatatgatt ctgtttatat 50340 aaaatgtcca gaaaaggcaa atccatagac ttataaggca aatcagtggg tgtcagaggc 50400 aagggagtga gcacttagga gtgagtgcta atgggtatgg ggttcctttc caggatatga 50460 aaatactctg gaattatata ggggtgatgg ttgcacaact ctgtgaatgt actaaacact 50520 actgaattac acacttacag aaacaaattt tatgatacaa tgtatctcac ataaaaaaat 50580 gaaatcacag aatttatagc ttcaaagttc acagagctta aatacttcct ctgacgactg 50640 ctgcttggtt aagcaagaag cgttgcaccc ggtggcttga tggggtctga gccattcccc 50700 tttgcaataa gaatagctcc ttccatatct ccaaagtaga tctgaggcct tgccacacag 50760 gtgttccact tttctaaaat tctagtgaat caaaaagata tataaacata tcttaaaatt 50820 ctcagcaagg aaagtatttt atccatagca atatgtttcc agaatccagt ttacattact 50880 tacatccata ctgctgttac aaacaaaaat cagtaacaga ttcttacaca tttacataaa 50940 gaaattagaa ttgagagaat tagaatggag taagcaagtt gagtctcttc tgttcagcat 51000 tttctcccac aaggatgtct ggcattccag acaaattgtc tggagaaact gttaccttta 51060 actgagttgg gataattctc ccatccagtg tcttttgttt agctgaagga ttttcctaac 51120 cctatcagag gcccaagagc aacttagccc cttcctgctg ctgcagacct tccctagact 51180 gggcattgat ctttgccata tgattgtccc ctaaattgtg aagaagggta aggcctttag 51240 ccttgtgctg tctctgtttt tggaacatct caatctacat ctttagagga ccagagagaa 51300 gctgtgacca ccctctcctc catcgttttt tttcttttgt taattgttct tattcctctg 51360 gttttatttt atcttatcta catcaccaat gacataaaaa gattctttca atctcaaatg 51420 ttcctgctac aacaggattt tgatttgatg ctcctcagca ctggctgaga aaacacaatc 51480 tgcagcggcc acatatattc cccaaagctc tgcccttttg agttgaaccc caactttggc 51540 ctctccatgt gggactctgt ctaaggaatg aaaggttgct ttgggagttc aaggtctcca 51600 aaagcatctc tcctatcttc ccccaaattt tctattcaag ccaagaccaa gtcataattt 51660 gctttgtcta agattatgaa cggaccttgt cttacccaca ggtcgattgt ctttgataat 51720 aacactagtt atagccacac tggataactc aaactatcaa cataatatct gccaaaacaa 51780 tcatggtact ttattggtat ccatagagtt tctttcctca tgagatattc agaacccgct 51840 ggctagtacc tgtgcaaaac ttactctatt cctgcttcta cattctatga acactccaaa 51900 gtggacattg ctaatcagat tggtcctaga tatggagacg agataattag aagagggatc 51960 ccttcacttg aggacagaag ttcgagacta gcctggccaa catggtgaaa ccctgtttct 52020 actaaaaata caaaagttag ctgggtgtgg tggtgcacac ttgtaatccc gctacttggg 52080 aggctgaggc aggagtatca cttgagctta ggaacagcga gccgagatcg caccaccgca 52140 ctccaacctg gatgacagag tgagacccca tatcaaaatt aaaaaaaaaa aaaaaaaaaa 52200 aaaaaagaag aagaagaggg atctctgcat tttaattgca ttttaactta ggctccctgg 52260 ctcataattt taaacttttc atggaagact taacaagttg aaggtagcct ttcttggaat 52320 tgtcacctaa ctttctcttt ttctttatga ttcctgtggc ttggttgtaa acggacttga 52380 catccatatt ggcactagct gggcctctct acagacacac aggcagagtg gcaggccctt 52440 cttaggcgtg gaatatgagc cacagcaatt cagcatttga ccagagtact gcatagagtt 52500 ctgcagaatt attaattatt tagtgaacat tttgctgtta tttcttctga taactttttt 52560 taaaattttg gaagaatgta tggataatca taggttaaat ttgtggaaat tattggcttt 52620 cttactataa catcattgta atattccaca aattaaggga tttcctactt gtagttgcaa 52680 tattctataa gctattatta gcaattttgg cctggacaat tttgaaaaac aaaatgaaac 52740 aaaaaaacaa acttgaccaa caatgagaat tatagtaata aagaactatg tgaatatgta 52800 tatatatgag tgtgtctcta tgaattttaa attaaatttg gctaaagaaa ccaacctgtg 52860 caaaacttaa gctctagcaa tagcctcagc cttaatattt aaaagacact taacggaaat 52920 ttagcaaaaa gctccagcca ttgaggacaa ttttatcaga tgcccaaaat gtggccttga 52980 agcttatcta aaacctgctc aaaaaaatct gatgaataag gaatatggag aactttcaac 53040 tgggaagata agacatgaag ataaacatct gtgacttaag aaagacgcaa tgtcagctac 53100 tatggaagga ccaaggaaag tgacacccat gtaaagaaaa ggcaatttga atgtgaagac 53160 aatggggttg tcatcacctc atgtgaaagt tagccaccta ctagcaatga tctggaagga 53220 acaaaacaaa tcatagtcaa taaatgtgca aagataaata ttgtgttagt aactatttgt 53280 gcttttttct cttgtcggtt gtccaaggtg tcttagcttc aaattaggat agcttatgac 53340 aacatggtgg cagattggag taggggagga tatgcccata ccaggaggtc tggagctgag 53400 gattctgact ttatcgaagg gctaggcttc aagatggaag atcagtagtt tttgtttgtt 53460 tgttttgttt gttttgtttt gtttttttgt tttgttttgt tttgagacaa agtctcgctc 53520 tgtaacccag gttgcagtgc agtggcacga tctctgctca ccgcaacctc cacctccctg 53580 gttcaagtga ttctcctgcc tcaaccttct gagtagctgg gattaccagc acacaccact 53640 ccacctggct aatttttttt tttttcattt ttagtagaga agagtttcca tcatgttggc 53700 caggctggtc ttggactccc aacctcaggt aatctgcctg cctcagcctc ccaaaatgct 53760 aggattacgg gtgtgagcca ccacacccag ccgatggtca gtggttttgt aaacagtatt 53820 attcaaatgc agatagtaag tttagttgtg atttacaacc atatgatata taaggaggtt 53880 caactctgta ggatacccaa aacaagagta aactgaatgt aacagtgttt tgtataagtc 53940 agggataggg gtctctagtg aaaagtacat tccaagagca tatagaagca agtttcactc 54000 atttgaaaag atgctttatt aaaattaggt aaagtgatgg gtttccagtt ataaagggta 54060 gggttggcca aatatccatt ttcagtaaga atctgaaacc agtgggtatg gagcaacgaa 54120 aatctaaagg tcaaaccaag atacagagat ttagccaaca tggcaggggg taatgaaaag 54180 acctacaatt catggccagg tgtgatggtt catgcctgta gtcccagcat cttgggagac 54240 caagacgggc agatcactag aggctaggaa ttcgagaaca gcctgatcaa catggtgaaa 54300 cccatctcta ctaaaaatac aaaaattggc tgggagtggt ggcgcatgcc cgtggttcca 54360 gcaactggag gctgaggtgg gagaattggc tgaacctggg acctgggagg cagaggttgc 54420 agcaagctga tgtggcactg ctgtactcca gcctgggctg cagagagaga cactgtcaaa 54480 aaaaaaaaaa gacgaaaaag acgtacaatt attggatata tgtgtatcca gagtttaccc 54540 taactactgc agatactaag cctgctccat agccacccag caaattacaa aactaatgag 54600 tggagcaaga cttgggagtt gtagctgatc ttacacagtg cctttagtta agtgcttcat 54660 gttttctaga tttcctggtt tcccaagtta cttgtcaaat aagcttaaaa atcatttacg 54720 taatatttcc atttggatgg atttataaag catattatcc tatagtaaat aacaataaaa 54780 aaaacacttt gcttctccca attctattat gatctgtttt tgcccacaaa acacttctga 54840 caccaaatgt gtgggttttg tctacaccaa caaccagttc ttcaactaac tctccagaca 54900 tcaagtgggt gttcaacaat tcagttcaat tctgatgcta actttagaac ccagaggtga 54960 agggtgcagt cccacaagac tgctcccact tgacatgacc actgcaggtc ctggatttct 55020 catacttctg actgactggc tataaattgg gagttcccac aaccccctcc ttgggttcta 55080 taatttgtta caacagttta cagaactcag cagaccagtt tccttactac tggtagttta 55140 tttttataaa ggatataact cataaaacgc cggaagagaa acatagggtg aggtatgagg 55200 gttatgtgtg aagcttccag gccctctcca gctgtgccac ccacccacca tctccatatg 55260 gtcaccaaat tggaagctct gtgaactctg ttttgggatt ttattacagt ttcattacat 55320 aggcatgatt gattaaatca ttggctgttg gtgattgatt caatctctcc tgcccctttt 55380 ctgaccccag aggttagggt gaggttgaaa gttccaaccc tctactcatg tgcttggttc 55440 ttttggtcac cagcccccaa cttaaagcta tgtagggccc atggaaattc actgccttag 55500 cataaactca ggtacagttg aaagggctga ctatggatat caaaagatgt ttctctcacc 55560 gccaccactc aggaggttac aagaatttta gaagcctttg ccaggaacct gggacaagga 55620 ctaaatatgt ttcttattat attacaatat cacatactta atatattata ccaaagcaat 55680 gtattaatat attgcaatgt caatgcattt tcattactta agaaatgaat ccttggaaaa 55740 gtactttgaa agtcttgctt taatccaata catttgtctc aggaccagag atccagcaat 55800 ctgatccaga atatatccaa ctctgaacat ccttttccaa aaagtattgt tcactctatt 55860 ttctgcgttg ctgtctagtg tctgtccttg atccctttag cctctactct aagcattttc 55920 tttcctagag aaggagctgc ccagactcac ttatttctta ctagcctttg cacatactat 55980 tcctcaccac aagaatgcct catacttcac acactctccc cacttaattt gtgtgaagtc 56040 ctcctcctag atattcctag ctctcttttg tttgtatttg ttgagcacct attttgtgcc 56100 aggttctagg tgtttgggtt acatctgtga acaaaagttc tggcgttaac atctgtctca 56160 ctagatcctg atgttatacc cgtctcatta gattataaag tatgcccttt gcttacctag 56220 ttctcatgtt taactctagc tctgtaagaa aagaatccat ccaattaggt gaaagtatta 56280 ttcctgaagc ccagcatagt ttttggcatg tcttaatcat tcagtaagtg cttgatggaa 56340 tttaaaaaca atcacattat ttcttattca tttttttctt tgtttgctac agttgcatct 56400 atcaaaatcc tatctgggaa gctgtgtcta acatatccaa ataatttata gtgcaaacct 56460 caacagaagc ttctacagtt ttgccaagtt ccccttggcc atctctcagt tttctaccaa 56520 aaatgttttc tgttatctca gaaatatttt ctagagttag gaagagtcca gactgactca 56580 tttgaattaa gtcctccctt tgtcctggtt ggcttctatg actttgagaa acttacttaa 56640 catttttgag ccttgctctc tttatttgca aaacaggaat gactatggta acctccagaa 56700 ttatgctaac agccaaagaa ataggagtgg cgcatacctc gcacagtcgt gtgtctgaca 56760 tatagtagaa gctctataaa tgttagtttc ttccttctcc caagagaggg acttgccttt 56820 tatggaaagg attggggaaa gctatatggg aatgtcaaat tttggtaaga atgttaaatg 56880 aagacatttt aaggtgcaaa ttttatgtct cccttagctg agctttcatt attcaaagga 56940 ctgaacagga gtaacttgag gtaaaggcat catttaaaaa aattactgac tttatctaca 57000 gaggctcttt cacttgcttg aggtctgtaa ttaagacttg tctgaataag cactagtagt 57060 ttaatcgagg tataagagga agaagatgaa atgcagggaa gatggagctt ccagctttct 57120 tcagaatgaa agattactca ctttagagaa cagagtgagc cttcaaaaac tgcttacaat 57180 gggaaaattt taacattttc ttttaactac acaagtaaca tcaatgtgct aattattcta 57240 aaatgagctc agaatttgct gtatggttac actttatgaa atacttgagc tccattacac 57300 caagaaataa aacgctgcaa attcatttct gttaattcat gcataattga agaaagggtt 57360 ggtgtgaaga ctctagaaca tgcatatttt tgtttctttg ttctcactgc cattatagtt 57420 gaaggtttac aataacaaaa aggggtaaat acattggact cataactttt atgaactgtt 57480 taaatgcaca atgaaggtga ttcataaaag tctctaattg tataagcaca tcactaaata 57540 tggattgtaa aatatcttgt ttacttttta tataaaccta ctatagatga aggaatattg 57600 caaacatagc atgtattttg tgcagaatgg agattggatc tacttttaag aaaagtggtc 57660 ccacatcatt gaggccaatt tttcttcaat tcctttttaa ccaaaatcag aaaaatcatt 57720 ctggtaacat cttggtaaat ataaatgagg gccatgttta gctgaacttc ttaattaaag 57780 ctttaagcta aaccacattt ataataatag ctaaaagaga ggttttgaat gtcttcatca 57840 caaagaaaag ataaatgttc aaggcaatgg atatgctgat taccctgatt tgagcattat 57900 ataatttata tatgtattga aacatcactt tatactccat aaatacgtac aatgattaca 57960 tatcaattat aaattttaga catttctgct ttgaaaatct tgttaaaatg tttgaatcaa 58020 gcccctgctg cccctaggcc ccaccttcta gataaatata acatactatt atgattagat 58080 cattatttgt cttgctaggg tttttgtgtg acattaagaa agtcacaata gctattatat 58140 aatgatcagg tagtttaggc caaacatatt tgtaattacc tgttctcctg tatgcctctc 58200 caaccccacc ccctaccttc tagacagtga tccaggaatc aacttcttca ggcatatatc 58260 aggtactgga ggcactcagg actgttcatg aatgattttt tttttagttc atttgtgaat 58320 aaatacatgg tgggagaaat ttacagtaaa catctccaat cccctgcaaa ctctttgtgg 58380 cagcattaac taaaaaagtc tgagtcatct agccattgta acactgagga gaaataagag 58440 gaccgagttc cacaccaggt cttcgagatc taacctgagt tgtttccagt gctcaaactg 58500 tgctacaacc ccacctgccc aaacaggctc actggcttgg attgcaggaa actaaaaaat 58560 atacagggga tgaggggttc catggacttg caccaacctc tgaaaggtgg gtttctgggt 58620 ccagataaag gtaatttttg gtttgcttcc aaattgtttt ttagcaagta tctttggtta 58680 gtggaggttg tggttagttt ctctttaatt ggtgttttct ccacctcaat gcctgatact 58740 tgggattcta tagaccaggg gagactctgg ggcttatagg ataacatcaa ttttgagcat 58800 cagcctagcc taatataatt gggatgggtg gggttcttcc caattagcaa ccacacagat 58860 gactgaaatt aaagttggtg gttagaaaag tcatgcctag agagtaaaaa ggaaagttca 58920 ttagtttttg tagaggcaaa gggagaactg cccattggtc ctctgaaggt tcactgaaaa 58980 tcaactgaca aaaggcagat tcataggagg aaaggtatag aaatgtacta acacgcacaa 59040 gggggaaatc ccacagtgat tacctcacta cccaatgagg tagaggtcct tatataccct 59100 cttcctagga gaaagggaga tggggaagta tggatgattt tgaggggtta gtaaattatc 59160 tttaggatta tcaatggatt tgaaaaacat acaatggcct gggacaaagt ccggcgggcc 59220 cacagaatag tttgtgacaa aagtctgccc agctgcgttg acaagcttca gtttttcttc 59280 ctgcgatatg agattcagtt aatgaaaact cagggaaggg accagaagtc actgtcacca 59340 ccttttggtg gtctggacct taggcagatt aggacacttt agagaacgat tttatcctgt 59400 gctttggaag agagagggtg gagctgggga gggtcacaga gaccttgagc ggcttcttca 59460 gttcagcaag ttgaagcgcc atattttggg gtataggttt ctgatcccca atgccttctt 59520 cactaaagct gaatgctttg gaggggaaca tgttccagaa gaaactgtgt aagtttggga 59580 gtcagacaaa actagatcct aatcctggta tacccattta tcgactatat aactttgaga 59640 cagttactta atcctgctca acctcagttt ctgttctgta taatggggac tcacacctca 59700 cttgtgaagt tgggataagg aatattacac atatatatga tatatttgaa gtacctaaac 59760 cataagtttt gtctttaaac tctggctttt tgcacatata ggttgtctga attcttggtg 59820 gaacttacag aattatcatc atttgaggtt acagccatca gaacttcaca ataaactaaa 59880 tatcattttt ggaggaatta tacataatta aaatatttgt agcctgcatc atcagtggta 59940 gttgccaaga ctgtgagaga tgaagatata tatatatata tcttcatctt gtggcaccta 60000 gaaccaacta ataagcccct agggagaatg ctaaatggct atgatttcct catgccctgg 60060 agttatagct gaggctaaat tacagctgta gaaaccgaaa agctggaaac agaagccatc 60120 agcccagcat gctcttccca aggcactcgg ttctggaagt ctgaaggccc tggagtggag 60180 ctttaagcca cacttggact aagaaaaggg atataatttg tgaatgccct aaacattgaa 60240 ggcttttatt atttgaacgc tttgattatt tgaaggcttt tattaaaatt taaaaaacac 60300 aattttcaac taattaatgg attagtttat tttatcattc agaaagcagt ataaacctgt 60360 gtatataaaa agtctcctta aatttatcct ccatgttttt attggtttta agcacataaa 60420 tacataaaag tgcctacacg gcatctctcc ccttcaaaca tagattgcaa tacttataca 60480 atggtaaaag ttggatgtat acctttccag aaatgtatgt aatggaatac acagagagag 60540 agagagagaa agagagaaag acagagagag agagagagag agagagagag agatcattct 60600 acatatattg ttctgtcatg agttttgttt cataatacat gtggacaaat taatacataa 60660 tggccttttc attctgttta ttgcttatat aatattcttt gcacagatgc attatgaata 60720 atttaaacat tcttttcctg atatacacgc agacttgaca tcgtttgtta ttttggctaa 60780 gtccaactct cctgcagtgg atattctttt atgcctttgc atgcattctg gggaaagact 60840 gtttgaagta gttactaaag ggtgtgtaca aattgccgtc caaaaatgca tttttatcca 60900 caatacatgt cttctcattc ttaccagctc tagatgtttt gttttgtttt tgaacttgtc 60960 agtctgaaaa ttaaaaatgg catttaattt tactaatatt tgtgtttttc taattactag 61020 tgagcttgag tatatttaat atctttatgt cgtggaaatg aatttactgt cgagtgagct 61080 ttcctctgat ccatgcccac aatatgaaaa ccagtttctc tgattacaag aaaacagagg 61140 agtatgtgtg tggcctggtg tgtgtgagtg tgtgtgtgtg tgtgcgtgtg tgtaacacct 61200 actgcagata agcaaggcct cgttggcatt ttcattgtgt ttgctctggg tattcatttc 61260 tgcaaaagca cacctttttc taaataaaac taaattcatc ataggtcttt tatttctaat 61320 ttggaaatat tttagaattt ctcaaagtat cataaaataa tttagaaatt attttagaat 61380 ttctcataaa taccattcaa actcctaaag aatatggaga aagatatatt ataaaacaag 61440 aacttagaag ctctacttta gaggaatttt taagcatgaa atcatgtcta gttcccaatt 61500 ctaaaaaata gcccttgact cagtcagccc acagacatta agcatttgtg acatgccaca 61560 agtaggctgg tatggagatt cagaaacgaa ggggatattc tctaccttcc tggagccctc 61620 caggggagga ggaagtgaaa agtagagata agcataatac agtgcctgaa tgctataaat 61680 attgagtgta gtggcaaccc gaggaagggg agtgtttggg acctgctgcc tgctttattg 61740 tctcttgtca caggaggaaa aataattttc tcctgtgaca agagaataaa acctcaggac 61800 cttccaaatt tactatgcca agggggaaag ttaaaccttg aaaacgggct tgcataacac 61860 aactgttttt cttctctggt tcctgactac tgcttactga cctttgcgtt gagactttat 61920 accttgacca gactccctgt tcttcattca aacctagact agatgacatg aagatagaga 61980 cccttgtgac tattaccctt tatgacagaa tgttaagcaa gccttttaga gtgtaatcaa 62040 tagtagccaa tcaaatctta tatctgtatg ttagcctttg tacggaaaat gttatagttc 62100 agcccctcca tttttgctta tagaaacaat cctcattttt cccccacact aggagcactg 62160 atcactattc tttggtgtaa ttctgctccc ttgtcagctg ccctaccttt gtgcttgagt 62220 aaactctttt aaccggatgc tgagcctttt gactgtttta tgttggcatt cgctaccctt 62280 catagttctt agctgggaca aatccctgta acaaaagaaa gattcacaag agaaaaacaa 62340 acagaagttt aataacatgt atacttcatg tgtacataga agatatccag ggaaaatgag 62400 taaatctcaa agaagtggct taaatttagg cttaaatgcc atcttcagct gaaatgataa 62460 gagtatttgg gtaaggagca gttaatggga agatgaccac agaagcacag gaagcaggat 62520 aagttttgtt atgcaggttg gtccatgtct tctctataga tgagcgtttc tagtgactga 62580 gagtcatcct tcccttcctg ctacggagaa gaagacattc ttacaaatgg atgtttcctt 62640 tatagatata aattgctctt gtgaaaggac aacttctact gttttcagag cttcttttat 62700 ctttgctgtt gcccaaatta atcagttcaa aataatcctt atgctaaaga ggcatatttt 62760 ggggtggcat attctggtct cctacagtca tattttgttg tggtacatac taaacaccac 62820 tactccgtaa cagctcatat gctgaacacc actatgcagc aacagctcat atattaaata 62880 ccactactcc ataacagctg taaaattctg tctaaaaaga aatctgcttt ttgtgggtgc 62940 atgtgtgcat gcttgtatgt gtgtgtttgc atgtactaaa catttattga attcgctgat 63000 ctacaaaatg tatgaccaac ttccatccag aaattttaat aagattgcac cataccaaaa 63060 gccagagaat caggagatag attacagact atgctgtaat tcaactacag aatacagaag 63120 tagaggggat taataaaggc taaagttgga tgggtgtggt ggctcatgac tgtaatccca 63180 gcactttggg aggccaaggc tggtggatca cctgaggtca ggagttcaag accagcctgg 63240 ccaacatggc gaaaatccat ctctactaaa aatacaaaaa aattagccgg gcctggtggt 63300 gggtgcctgt aatcccagct acttgggagg ctgaggcagg agaatagctt gaacctggga 63360 ggcggaggtt gcagtgagcc gagatcatgc cattgcactc cagcctggat gacaagagat 63420 aaacttcatc tcaaaaaata aataaataaa taaataaagg ctaaagttcc acatttgcaa 63480 tgagttgcta caaccagcaa aaaaattaag gtttttttca gatgctagca gtcacagagg 63540 tgaaggtgca ggaatcagaa tggagagatc attaggagca aagaaagcag gcattaagat 63600 agaatgaatc accaaagctg ataacacttg aagcccctga tttcaatttt aatgattcct 63660 ggcatggttg aaaatagttg acatactgtt cctctattat atttgtgttt tcctgctgcc 63720 ttcactcttt cagacagagg gagtagagct acaaatatta aaagaaaaaa atttttttgc 63780 agtattttaa aaaaagctaa gttaaaagtg ctgaacattt tgcaaaaact tgtccttgtc 63840 agttctggaa actcaagggt tccatgtaat tcgagtaaac aaagaacacc tttcactgac 63900 actttctttc tttttttttt tttttttcct gtctcactca ttccagtaac attttggtcc 63960 ttgcattcct gaacatcttc ctgggaaccc accgtttctt cttattactg gtctattgct 64020 gtgctttata aaccccttaa agaagctttg aacactctga agaactgaat aatatatctc 64080 agaggaaagg tatagactaa attgactact gcaaatagtt tgcacagaaa agtaatgttt 64140 ggaaaaatag attggggtct cagtattggg gcatggaatg tttggttgtg gagtttagag 64200 cttattgaat aggcctcagg gatacacact taaaaagtaa tgctttggtg agattaatca 64260 gatgtaaacc tagagaatga ctgtaggatg gggataggag aagatgctga agacagacta 64320 ttacaacaat atgtgttata gaaatattat ataatactac agaaatattg cagaaatact 64380 attgcagaaa tatagaaatg tgagttgcaa attcatattt gaaatattgt cgaaagggaa 64440 gattaagaac acatgtagag tcataattca atcattaagc tttttatttg acatttgtgt 64500 tgcatgattt gagaagattc aaagatgtat caagcctgtt ttaccctgta acagcttcta 64560 taactaattg aaacttttgt ataaaattta ttcaagcaca acctgctgaa gaaagctttc 64620 tctgatacca tgcaacattg agagtgatgc tcagcttgat gctttcagaa tcttggtggt 64680 ttctatcatc aagtgctctt cacactgtaa tcatgatctc tttatatgta tactatccac 64740 tttacacggt gaggcccttg aaggaaggaa ctatgtctca tttatgtagg tacctcagag 64800 aaagtagtgc agtgcctgca acagaggacg aatcagcatt agccaaagga atgatggctg 64860 caagtatggg aagaaacaca attctggtac aaagtgttgt caataccgtt gggtaaaaaa 64920 agtattattg cttgtataag agctgggcaa gtgttggaaa accagaagaa tggtaatttt 64980 tctgtgaaga aattgagttc atttaattac atgttgcatg tgaagagata tttgctgtct 65040 ggcaaaaatg taaagaagtc aagtcaaaag cacagcacta tcaaggacgg aaagctctac 65100 acagatttgg agaaggaaaa ttaagtgtta gatttaaaga aagaagaaag ggcctaagga 65160 atgagggaat aaaggagcag cattaaaaat caaagagatt aaaaatatgt aggaagttga 65220 atacaagata aattggactg taaaggtcag tttggagaca gagcaatcag aggattctgg 65280 agaccaattt cttttctttt cttttttttt tttttgcgat ggagtttcac tcttgtcacc 65340 cacactggag tgcagtggtg caatctcagc tcactgcaac ctccgcctcc aggttcaagc 65400 gtttctcctg cctcagcctc ctgagtagct gggactacag gtgcccgcca ccacgcccag 65460 ctaatgtttg tgtttttagt agaaatgggg ttttaccctg ttggcaagcc tggtcttgaa 65520 ctcctgacct caggagatct acccatctcg gcttatcaaa gtacagggat tacaggcatg 65580 agtcactgcc cccagcccca gaggccaatt tttacgcagt gttgatctta tggcattggg 65640 cacacctgct gctcaaaaag atatagcaac cagggcatgg agcgtcaatg tagcagtcta 65700 gagagcagct agggttgtag aagttgcttt tcaaaggaca gtcccagatg gatttataga 65760 tgccattcag ttattcatta ttgcaacatt ttttaatgtt tattggctaa caccgtttga 65820 gaaactgaat tggctttaac acatttttgc taaataaatg ctagatgctt tgaacattac 65880 acaagtaaga tacatgctct ataactctaa ttctaagtaa aacatgaaga ttttaaggga 65940 cagagaggac cagttagaac accatgaaaa ggcatcagtt gatttgatgc tgaaagataa 66000 ataacatcct agcaaataga atttgggaaa aggaattgtg aaagagaaat ctagacatca 66060 ggaaatgcag gaatagacat tttataccag aaaatagtac atgtgtctaa gaaaatggta 66120 ggagttctgt ttagtaaaat aataggacat gtgcgtaacc tccattaaaa tgaagattct 66180 attggtgaga tactcacttc ataccaagtg aaaggccgat gcagttcaag gttgataaat 66240 gtacataata agtaagcagt cattctgcac acatttatga aaatgccctt agagaattta 66300 tccctctccc atagctcgtc ctgtgctttt cacactgagc ctcaatttta ttcacaaaga 66360 tcgtgataaa aagcaactag tggaactgaa agtcattaaa tctgaaaaca gccttggacc 66420 aggtagagaa accaggagcc agccaggctt tccttctgct taacaatgtg actttggaga 66480 tacttgataa gagaattctg agtatcaatt tccccatatg ttaaaacagt attgagctaa 66540 atgatagctt caattctttc tggccctgaa tagttgtaag tttatttctg ttttttgttc 66600 acatttgttt aaagacacag aaagaaagtg catgatctgg acaaagcagt accttctgat 66660 gatgttttct ttcccccaga tgattcatat aactacataa tgggatattt aaaaacaaat 66720 agaccgggca cggtggctca cacctgtaat tcctgaactt tgggaggcca aggtgtgtgg 66780 atcacttgag gtcaggagtt tgagaccagc ctggccaaca tggtgaaacc ccatctctac 66840 taaaaataca aaaaaattgg ccaagtgtga tggcaggcac ctgtaatctc agctacttgg 66900 gagggtgaag caggggaatc tcttgaaccc aggaggcgga ggttgcagtg agctgagatc 66960 acaccactgc actccagcct gggtgacaga gtgagactgc gtctcaaaac aaaacaaaac 67020 aaaataaaac aaataaacca tgataaaaac aagtgacact agcatcctat aattctatag 67080 attgagtaat gacatagtaa caaattcact attgcagaac tggggtggga gttccactcc 67140 ctgggcaaat taaatccacc caagtcatca gacctttaat tttcatttta aagtgagaaa 67200 atacacaaga aatcatctaa aaatataatt acagggtgaa ataaataagg cagagtatgt 67260 gtgtgtatgt gtgtatttta agttactctt ttcagaataa atggctttag gaaattattt 67320 ttgtggaatg agtttctcta ctatcaagga gacttccctc tactgtattc aaatttaggt 67380 aaaataatag gtaaaagtgc atattccagt actaaactaa taagcaatca gaaggaaaaa 67440 tagatttcag ccgttatgcc catagaatga atttgattgc tgaaggtggt atcttcagga 67500 tcctgttatt gttacttttg ctgaaataat aggccagatt ttattttata aaagaaaact 67560 atagattttt cttctaagtt cagacttgcc agctagttct actgttatta ttctgaagtg 67620 cataaagtcc tcattaactg atgccagctg accgggaagc acgttgatag atgccttctt 67680 actggtgggg aagttcactt aacatctgta cttggacgtg caggcgggtg cttggcaggt 67740 gacagcctgc aatgggtgct gtcatgctat aagcaagcag gctgcagagc cagagtttag 67800 cttctgttta gctctctttc ccagcataat gtgtgcaaaa cacaagtgat gaaattgatg 67860 cacagcgctg tgtgttccta caccactgca ttatatgaat aaggaacatg gaacaaaatg 67920 gcaacattaa gggtatgtca gattatttcg cagaaatctg ttcctttttc ccctgcagtc 67980 aaacccacag cattctatct cagaaatgaa tatagaggat tctgttagat tttgccttga 68040 ggtttgtatt tgtcccaaag agaaaaggag acttatttag aggactggtt gtgcagagtt 68100 gaggacatta gcctttctct caggcattat gagatgtcag catgattctg caactcggac 68160 ttcacaatat caagtgttcg catatttctg gaaaatgtga aagtaggcag ccagaaagtt 68220 atttaaaata tgaagaattt acgtgaaaat ttttcttggg tccaaatcca ccaattggtt 68280 aaaaggttta cccaaactgt gtgcatccag atattccact gacaaatatc cattcattca 68340 ctcatttata cattcactgc acaaatatct attaaatacc tggtacaaca gaaaaattaa 68400 gagaaagtcc tgcttttatg aagtttatat tctagaagat ccttgtgatt ttagcatttt 68460 tataatttaa acatttttca tagatttgct gatatgtttg gctttgtgtt cccacccaaa 68520 tctcatcttg aattgtactc ccatcattcc catgtgttgt ggaagggatc tggtgggaga 68580 taattgaatc gtgggggtag tttcccccat actgttcatg tgctagtgaa taagtctcag 68640 gagatctgat ggttttaaca gggggttctg cttttgcatc ttcctcttct ttctcttgct 68700 gttgccatga ttctgagaat tccccagcca tgtagaactg taagttcaat tgaacttctt 68760 tttctcccca gtcttgagta tgtctttatc agcaatgtga aaacagacta atacagttgt 68820 atacctacac acacacatgc acacacatgc acacacgcaa aggcacacct acacgtagtg 68880 ttttcatcag ctagggtctt aataggaaga aataacagaa ataggaagca ataaaaaaac 68940 tgactgcagt ttgtttaaac taaaaacaaa ttgttgaaag ggtattgagt agttcataga 69000 attgtagaga atgctaggta accaggttta gatatgaggc aggaatatag aaccacagcc 69060 agtaaatact acagagccag caagggaaga ctctgccatc actgctgatg aacaaacaat 69120 attgtagctt caaccctgga gactggatgt tgccactgaa aaccataagc tcttgcatct 69180 gggctttcaa agttattgct tccaatctgc ctgtttctta ggatcacaga ctatgatgca 69240 agtctcaggg aggcaagttt gattggttgg gcctggtctg agtgaaccaa aagttgagtc 69300 ttagtgaaat acacactgca tttggtcaaa tgtcagcggt tgtgaaaaag gtagctacct 69360 gcaccctcat ccccatttta ttgtatcttc atgagacagg acatgtttga ttttacctct 69420 gtcatctcag tttctagcat aacacaggcc acatggaaca tatttattaa atgtaggaat 69480 ggaatcattt attaggtgtg gtggtgaagg tagctttata ctcatgccac acatttgcat 69540 tttttttatt ttctctgagg tttgagttag ctcctaatgc tttacctagg tttctaaagg 69600 cttagactag gatgagtctt tggtctcttc cagatcatat caggattcag gggcctttga 69660 gctcctttga gagataactg agtgttgagt ggactctgaa aggaattttt catccaggga 69720 aagaagtcca cagaggaaac aaggcagaga cagcagagct gctgctgccg gaggcctgaa 69780 aactatcaac tctttctgac tctcctctga gactgggcaa caagtgtggg tccacaccat 69840 tcttgtaact gtttaggatg ggttatgctg ccctgaaaaa ttcaccttga gattcagggt 69900 ggtctgcatg ggaagaaaag aatggtgcaa tattagtgtc ccatattcaa ggaggcttag 69960 ttcttgaaag gctcattatt cagagcagac atttaatcag agggagttga gtgttaaggt 70020 caaactcctt gagatgagcc actgtgagga gactcttcta cttttcaagc taatttcatg 70080 tgtgccataa atcttggaaa gttaaaaaga gggcgggatt tgctaggtag tcaatttagc 70140 aacattttct tacaacttta agacattttt ttctttacta ttagagaact atttagaacc 70200 tttaggactc taattatcat gcacacagct tggaagaaat taaccaacaa agttcagaaa 70260 gcaaaaagtt tataagacat aatttaatgc actttatata tttaaacagc aacaatgaaa 70320 tgctatcctc ctgtgatgta aagttctctc tttccacctt ctaaatataa aaaaacgtgg 70380 ctctcatata caaatacaaa cacacacatg tgcacacgtg aacacacatg catacacatg 70440 gacacacatg tacctcacaa actatattaa gaagaacaag agaaaaaata atccaattta 70500 tgtggtgctt acaatgccag actaaggagg tgcttttact tgccttctaa tttattaatc 70560 acatagcaaa gttgacggta atgtactaaa attactgttt ttttttttgt agaatatagc 70620 ttagaatcaa agaggttgca tatgcttttc aagccaatgc agctaataaa tgacagaatc 70680 aatatttgat aatgaagggg tggagcaaga gagttgaata aaaggcttta ccaattgtcc 70740 cttctgcagg tacaccaaat ttaacaacta tctacattaa aaaaaaatcc accttctcaa 70800 gaccaaaaat cagatcagtg ttcacagtac ctgattttaa cttcatatca ctgaaagagg 70860 cattgaagag actaggaaaa gcagtcttga actgccaatg tcatccctgc cccatcccct 70920 ggcagaagtt gtataacatc aaaaactaat aatatttgtg cttgggagag ggagagtgta 70980 gtgattgtga aactctgcat tgacctcagt gttgccctgt catagtgaaa agcaaaattg 71040 ggctgaattc gccaatgcct gtgtacagag ggagcattta gatcagccat aacgagatga 71100 aaattgccca ttctagaggt cagaatttga gttctggaaa gcctcaccat aggaggctaa 71160 agtgctctgg gtccctaaat aaacttgaaa ggcagtgtag gccacaagaa ctgcaactca 71220 taggcaagtt ctagtcctga gctgtgctct aggccagtgg gcttggggga ctcgtgtcct 71280 actgagatgc caactggggc agctaaggga gtacttgttc catccctccc ccagcctcag 71340 gcagcacagc tcacagctcc aaaaagaccc cttccttcag gagaggagag ggaagagtaa 71400 agagaacttc atcttgcatg ttggatgcca gcttagtcac agtaggatag gacataggga 71460 agagttaata ggcctccatt ccaggcccta actccttaat gacatttcta gacacaccct 71520 gggccagaag ggaaactgct accttaaagg gaaggaccca gtactagaaa gatccatcac 71580 ttgatgattg aagagccctt gtgccctgaa taaccagcaa caacacccag ttagtgtgct 71640 atgggccttg ggtaagactc tgagacatgc tggcttcaga tgagacatag catattctca 71700 tctgtgatga ctatggtgag aaactccttg tccttaagaa aagcagaggg aaaagtaaag 71760 aggactttat cttgcacctt aggtacaagc tcagccacag tggggtaatg caacaaatgg 71820 gctcctaggg tttccaactc cagattttga cttttgtaca gcattactgg acctggctgg 71880 gtgagagggg agcccacttc cctaaagggt gagttccagg gctggcagca ttcactacaa 71940 tctgacggaa gagccattaa gccttaagtg aacgtcagcg atagcctggc aatactctgc 72000 atgggcctgt ggtggtggtg gccatgggat gagccccctc tgcctgtgga aagataaagg 72060 aatagtgaaa agagctgtgt ctcatggttt cagtgcagct cagttgcagt agaatagaac 72120 accaggtagg tttctaaagt tcttaactct agtctctggc tgccagatga aatctctgga 72180 tctcactcag tgcctggggg aacttgtcag cccaaaggga aagacagaac cctggctggc 72240 tttgtcacct gctgactata gagccctagg gccatgagtg aacattggca atagcgaggt 72300 agtggtaaca gtgggctttg ggcaagaccc agttctgtgc tggcctctgg tctgacccag 72360 cacagtccca ctggtggtag ccacaggggt gcttctgtca ctttatcctc agctccaggc 72420 agcccagcag agagaaggag attccatttg tttgggaaaa agtaagagaa ccagtgtctc 72480 tgccaggtaa tctagagaat ttttccagat tttatccaag accaccaagg tcttgggcaa 72540 gaaccacagc attactgggc ttggagtgct ccctaatgca gaaataactt agatcacaac 72600 atccaagact tttttttttt tttttttttg ctatctggaa agccttccca agaagaacag 72660 gtataataaa gcccagacat tgaagactac aatacctaac tcttcagtga tgagacacca 72720 ataaacatac ataagcataa agaccatcta ggaaaacaag accttaccaa atgaactaaa 72780 tgaggcatca gcaaccaata atggagaaag acagatatgt gacctttcag atagaggatt 72840 caaaatagtg ttgacaaaac taaaaaataa tcaggttaac tcagagaaaa aaattcagaa 72900 ttccatcaga tatatttagc aaagagatta aagttaatta agaagaatta agcagaaatt 72960 ctggagctga aaaattccaa ttggcatact gaagaatgca tcagaatctc ttaccagcag 73020 aactaatcaa gaaagaaaga aagagagaaa tggcgagcct gaatgcaggt aatttaaaca 73080 tacatacagg agacaaaaga aaaaagaata aaacatgcta caggatctag aaaatagcct 73140 caaattggca aatctaagag ttattggcct tatagagaag gtagagaaag agagagaggt 73200 agaaaattta ttcaaagata atatcagaca atttcccaaa cctaaagacg atatcaatat 73260 ctaagtataa gaaggttaca gaacaccaag cagacttact ccaaagaaga ctatctcaag 73320 tcatttaata atcaaactcc caaaggtcaa gggtaaagaa ataatcctaa aagcatcaag 73380 aaaaaagaaa caaataacat acaatggagc accaataaat ctggcactag acttttcagt 73440 ttacacttta caggccagaa gagtgatgtg acatatttaa agtgctgaag gaaaaaaaac 73500 tacacaaaac ttttatccta gagtagtata tctggtaaaa atattcttca gatgtaaagg 73560 agaaataaag actttcccag acaaacaaaa gctgagggat ttcatcagca ctagacatgt 73620 cctacaagaa atgctgaagg gagtacttca atcagaaaaa aaaggacatt attgagcaat 73680 aagaaaccat ctgaaggtac aaaaaaacac accaaaactt gacttgtact agtaagtgca 73740 aagaagaaca gaatgttata actgttaact atggtgtgta aactaaattt tcttaagtaa 73800 aaagactaaa agatgaacga gtcaagaata acaacctttc aagacacaga cagtacaata 73860 ggatataaat cgaagcaaga aaaagttaat aagccaagca acacagttaa agtgtagagt 73920 ttcaatattt ttgtttgtgc ttgttagttt gtttatataa tcagggttaa gttgtcagct 73980 taaaatgatt agttatagaa taatatttgc aagccttttg ttaacttcaa atcaaataac 74040 atacaacaaa tacacaaaaa taaaaaccaa taaatgaaat cataccacca gagaaaatta 74100 tctttactaa aaggaaggca ggaaagaagg aaaaaagaag gagaagacca caaaacaacc 74160 agaaaacaaa taacaaaatg gcaggaataa gcccttactt ttcagtaata actttgaatg 74220 taaatggact aaactatcca ttcaaaagtt atagagtccc tgaatggatt aaaacaaaca 74280 aacaacaaca aaaaataaga aaaaacaaga ctgtatgatc tgttgcctac aagaaacaca 74340 tttcacctga agacatacat agattacata taaaagaata gcgaaagata ttccatgcca 74400 atagaagcaa aaaaaaaaaa gtggaagtat ctatactgat atcagacaaa atagatttca 74460 agataaaaac tgtaagaaga gataaagaag tgttcattgt tagtatatgg aaatacaagt 74520 agattttgtg tgatgttttt ataccctgaa attttgctga gttcatttat tcattctaac 74580 acatgtatgt gtttgtgtgt gtatgtgtgt gtgcctgtgt atgtgtgtct gtacatgtaa 74640 ttttaggatt gactgcgtat aagatcatgt catctctgaa cacagggtga atttttcttc 74700 cctttttttc tatttgaatg cctttatttc attttcttgc ctaattttgc aacaaggatt 74760 cccagtactg tgttgaatag aagtagcaaa aacaggcatc cttgtcttgt tcttgatctt 74820 agaggaaagg ctttcagtca ttaattatat tagctatgga tgtttcatat atggccttta 74880 ttatgtggaa atatattttt ctattcctag ctttttgaat ttttattcat gtaagaacat 74940 ttaattttgt aaattttttt ctgcatctat tcagttgttc acatagtatt ttttcttcat 75000 tctgttaatg tgtataatat taattgattt gcatatattg aaacatcctt gcatccaata 75060 aataattccc cttgattttg agtgtatttt aattttaata tattgttgaa attagtttgg 75120 tagtattttg ttgagaattt tacatccata tttatacagc atatgagtct gtagcttttt 75180 tatgttacag tggttttatt tgtttgtttt ttgaatcagg ctgatactgg acccagaata 75240 agttaggagg tgttcctgct tcaatatttt ggaggaattt cagaagaatt gatgttaact 75300 ctaaatgatt ggtagaattt atcagtaaag tcatcttgct caagatgttt ctttattaag 75360 aggtattgat tactgactaa atctgcttac tagctatagg tttatttaga ttttctattt 75420 ctttataatt cagccttgga aggttgatta tttattggaa attgcctggt tcatctaggt 75480 tatccaattt gtttgtgtgt taccattcat agcattttct tacaatcctt tttatttgta 75540 taaaatcagt ataatgtttc cactttcgta tctgatttta gttatattaa tctttttcat 75600 agtcaattta gataacttta ttaattttgt tgatattttt gaagaatcag ttatttgttt 75660 tgttaacttt ttaattgttt ttctattttg tttacctctg ttctaatctt tattatttcc 75720 tttcttctgc taattttaca tttagatttg tcttcttctt aaagtgcaaa gttaagttgc 75780 tgatttgata tctttctctt tcaattaaag tgtttgtagg tatgatttgt tatattagca 75840 ttactttcac tgcaactcgg aagttttagt aaattgcgtt gtaattttta tgaagatatt 75900 ttctaatttt tctgtaattt tttttattta ttgcatgtct aagggtgtga tgcttaattt 75960 cctcattgtt gtgaattttc cagttttcct tttgatattg attttgagtt tcactccatt 76020 gtgattgaaa aatatacttt atatgatttt aatcttttaa aatttattga cttgtttttt 76080 tgcctaacat gatctactct ggcaaatgtt gcatgtgccc taaagaaaaa tatgtattcc 76140 attgttgttg ggttgaaaat tcagtgtgtg tcttttgggt ataattggtc tatacttatt 76200 gttcaataga aatttcttat tgatcttctg ttaggttgct atatccgtta ttgatagtga 76260 ggtattgcaa tctctatttt tgtagtgcta tttccctctt caattctgtc agtgttgttt 76320 tatatatttt ggagctctga tatttggtgc atatatgttt ataattatta tatctccttg 76380 gtgaattgac catttatcat tatatgatgt tttctttaac tcttgccaca gtttttgact 76440 taaaatctat tttttatatt attagtgtag tcatcttgcc cttttttggt tactgtttgc 76500 aagtaatatc tttttccatt ctttcacctt caaattttgt atgtccttcc atgtaaagtt 76560 attctatagt tggatcatgt tttattatac attttctcaa actatgtttt ttgatcagag 76620 aagttaatct atgtaaaact aaaatgacat ttatagggaa ggagttactc ttccattttg 76680 ttttttgttt tctccttgtc ttgaatggtt tataagaatc cattgtcttc ttcttaatca 76740 tcttctattg tagttaatta attttttagt ggactgtttt gattcccttt tcatttcctt 76800 ttacaaatat tctacagatt ttattttttg ttaccatgga gattacttat aacattagga 76860 agttataaca atctaaggtg ataccaagtt aaatttagtt acatacaaaa actccccacc 76920 cttacagccc cccctatttg aggttattga tgtcacaaat tacatcatta gttattatgt 76980 actcaattaa tatagattta taataatatt tattcattag ccttaaaaat gctgtaagaa 77040 ataaaacctg aagttaccaa ccaaaatgaa aaaaataaac cttgttttta tatttgccca 77100 tatctttatc aaagatttat atgtcatcat acatttttga gttactgcct atcatctttt 77160 cattttgacc taatttattt catttaacat ttcacatagg gttggtctag tgataattaa 77220 ctctctcaga tcttatctgg gaatgtctaa tttctcccac aaacctgtct gaaggacagt 77280 tttgttgcat acaagtcttt cttgacaatt ttaatacaag atccctctgc cttctgacct 77340 gcatgatttc tgctgagaaa tctgcttatt atctcattat ggatttcttg tatataatga 77400 cacttcattt ttattttctt tttgtgtgcc tgtgtgtgtg tggacttttt ttttgtctgt 77460 tgacaaaatt ctctttgtct tcagattttt aactgtttga ttataatttt tttaatgtga 77520 gtcttcttac atttattcta tatgatgtct gttgagcctc ttaaatttgt agattcatgt 77580 attccatcaa attttgtaag ctttccataa ttatttcttt agataatctg tcttctcttt 77640 ctctctccct tcttctgtga ttttcataat acagacatgt ttgtcccaca agttccttaa 77700 gttcctctgt tcacttttct tcacttgtcc cataacactt gatggtgtcc cattagttcc 77760 ttaggatctg ttcacttttc ttcattcctt tttttttctg tttgctcctt aaatttgatt 77820 atttcaaatg tcttttcttc aagtttgctg attctttttt atgcctgttc aagtatgctg 77880 ttggactcct ttagtgagtt tttcaattgt cattctattt ttcagctcca gaattttcag 77940 tcagttcctt tttacaatat tatctttgtt gatacaatca ttttgttcat gtatcatttt 78000 tctatcttcc tttatttatt tttctgtgtt ttcttttagc ttttagaaca tatgtaaaca 78060 gttgctttaa aatatttttc tagtacacct gatgcctatg tttcttcagg aaatacttgt 78120 actagttttt ttcatttgaa taggccatga tttttatttt ttctttgtat tccttcttcc 78180 tttttttgaa aattcatcat ttgaataaaa agttacttct tctggtcttg gcagagtgat 78240 attgtgtgga aaatacctcg ctaattagta gggcatgccc aaacaattca ttttgcctgg 78300 actatatgtg tgcttttttc aattccttta tatacatggc tatttttaaa tgtctttatt 78360 tgacagagag tttcatctca gcctatccat ggggatttag gtgatctatt atgtgtcttc 78420 atctgtattt tcttatgcca gagtctgcag gtcagtagtc cctggctgtt ttcatgcgca 78480 atgcctgtta ctgttttcca tagcttttcc caggctgaga tctgagctat gtcacttttc 78540 cccatacagc cttttctcca aacaagtata tatatagaaa aacttctggt ctttatttct 78600 tttcttataa ggacaacaat tctgttgaat tagggtccac tcttatgact caattaactt 78660 caattacctc cttacatgtc ctatttccaa atacagtcac acagggtttt agggcttcaa 78720 catatgaatt tgggtgaggg ggttccaatt cagtccatag cagacaaaac aattgcatgt 78780 tggtgattaa tatttgtttg ctttttattt atttattttt attttttgtg gttgctggtt 78840 ttactttttc ttaatatgtc attattttcc tttcattctt gaaaggctat tttaccaggc 78900 ataccattct aagttggcaa ttattttctc ctctccctct gataatattt gttccactct 78960 ctcctgaccc ttttggtgct attgataagt ttactgtttc tctaaataat gcttcttata 79020 ttcttactta aaaaaatcaa tttgcttttg gtgttctgta ttttcaccga aatgtgtcag 79080 gataattttt tgtctattca tagtatttag agtatgctat gctttctgaa tcataagagt 79140 tctttccttt ataatttctg gaaaattctc agtgatcatt ttattagttt ggttccattc 79200 tctctaagtt cctatgttct ctttctcttt atgttctgca tcaggaaacc tgagtcaatg 79260 cacgttagac cttctgaatt tattttccat ttatctcatt tttactttta ctcctctttc 79320 tctgagttct gcatttcatt aactttttcc tatattttta gtttactaat tctccgttca 79380 actatgttta atccgttctt taatatattt attgggtttt tgatataaag ggagatattt 79440 ttaatgtctg taaactctgt ttgattcttt aaaaaataaa catggtcatt gtatagctgc 79500 tttcccttct tatgctttca attctctgtt ttgttccttt acccttttcc catatgcccc 79560 aagaatactt tctagcagta cttgcggctg cagcatttac cctgagataa ctttgccaca 79620 aaatatcttg cttttattat taatttttgc accactctag tatacccact ttggaaacaa 79680 atgatatcat tctatttata gcattctatt tttagtagtg gttacttgta tttatgaaat 79740 atagtaattc tccatcgctg aattaataaa tccattttct tctaaatata tgattgacga 79800 ttcagatgat tctgatgtta gttctgttta gaaataactc aaacaatagc tttatatttt 79860 attttcacat taaaaatcag atttgcttca gcctcaaaga gtgtgtttat ataaaattaa 79920 atgagcattg acagtgagct gccttttttt ttctaaataa gaaaagggtt aaacacataa 79980 agtgtatttt ctgtgtgtgc tattttcaat acctgaagtc tttggaagtc taattctgtt 80040 gttttttaat ttctgctgac tctccctaat aatggcttat tttcatgcaa attttgaaag 80100 attggggaaa acccaattaa tgtgaagctc tgtttaaaaa atgtgaagga ctgaggttat 80160 ggattttttg aggagaatat tttttcctct ctaccacttt gggtgctgta atttactctc 80220 tcatatctgt tctaacttac ctcccacctt ggagatgcct gatgccttct ctcctgtact 80280 gttaaatctc aatactctgg atcaccgtga atcattggtt ctcagtgcat ctgctagctc 80340 cagagtgtac tgttcaacct tcaggcttct gctagtgaac tgaattcttt atttaaaaaa 80400 tcatatttta tctttttttt tttttttttt tttttgagaa ggggtcttgc tctgtcaccc 80460 aggctggagt gtagtggtgt gctctcggct cactgcaacc tctgcctcct gggttaaagc 80520 aattcccctg cctcagcctc ccgagtagct gggattacag gcgtgcgcca accatgcctg 80580 gctaattttt ttgtattttt agtagcggca gggttttacc gtgttagcca ggatggtgtc 80640 gatctcctga ccttgtgatc cacccgcatt ggcctcccaa agtgctggga ttacaggcgt 80700 gaaccaccgc gcccggccat cacatattat cttgtatttt gtagttttag ctactttttt 80760 ttttcttttt tcaagcttcc tgtttcttta tgagaaagga aatggtaaat aatcacttaa 80820 ttttgaagct ctttatgtga gtacgtgact gtgtgggaaa ataaaagaga cattaagcca 80880 agtgaattca ggaaaagctt ccaaaccaat agaagggaaa atatatggga gaaaaatata 80940 tatttttttc tttttttttt tttttttttt ttttttgaga cggagtctcg ctctgtcgcc 81000 caggctggag tgcagtggcg ggatctcggc tcactgcaag ctccgcctcc cgggttcacg 81060 ccattctcct gcctcagcct cccaagtagc tgggactaca ggcgcctgcc actacgcccg 81120 gctaattttt tgtattttta gtagagacgg ggtttcacca ttttagccgg gatggtctcg 81180 atctcctgac ctcgtgatcc gcccgcctcg gcctcccaaa gtgctgggat tacaggcgtg 81240 agccaccgcg cctggcctat atttttcaat ccaacagata acagaaaaga aataaaaaga 81300 agaagtctgg caactaggaa aaaaaatgat atggtttcat caaacctact atatcagtac 81360 tctaattcag aaggtttaaa gtaatctatt aaacgatttt tcaaaaatgg attacatatt 81420 tttgaaatcc aactttattc tccttataag acatgagtat tgaccctatg ttttacaata 81480 tctaaaactg tatagtaagt accgttctct accttagcat atatcaactc tcattgaaac 81540 tttaccatgt caccattatg catagtctct ttatgtgtaa acttttttag tctagaaaaa 81600 ttatttttaa aaatagatta tctctatctt ctttcttacc aacccatcct ctgggttaaa 81660 tttgcttctt tctaattttt tttcatactc atacttttag ttataaagtc tgtaagttca 81720 acttagtggt ttatatctaa agtttttatt ttggctttac aattgcatga ttgtttgcct 81780 tgatgtataa ttccagattg acaattatct tccctaagca ctttcattct attattccat 81840 ttttgtctgg catttattat tggtgatgaa acatctgctt gtcttgataa taagacattc 81900 taattgccat ttgctagtaa gtaacctgtt tttttgcttt agaacgttac attttttatg 81960 ttcttcagtt ttattactat atgtttactg tagatttatt tggatttatc ctttttaata 82020 tttaatatct tttcaatctg aaaaccatgg ttcttataaa ttatagaaag ttcgcatcaa 82080 aaaccttttc gaatgttttt tttttttttt tttattctct tctttatcta ctttgggaat 82140 tcttatgaag tgaataccaa agcctcttaa tctatctttc atgttttaaa atttctttca 82200 cattttcctc atccttttag ctttctgtat agtggtcagc agtgtattct aaaactgtat 82260 taatatactg tagatgttac atttttgaag acttttgttt caatggtcat gtttccctac 82320 tccagatttt tattggaatg gctctctttc tatattctgg ttacttctca tgcagcaaaa 82380 agctatcttt tcttaccacc ttttctgata aatatgtttt acttatctct catttctttt 82440 ttattttttg cttcatttct tctcataact catattactt cctgaaatgt ttgttcttaa 82500 tttctttctt tccccactcc ttctccctct ctttttcttc ccttcactct tgattttctc 82560 cctcactaca agtcagtagt gacttctgtg ttttgttcat gtttctttct agcacctata 82620 atagcgcctg ctacatagta atgttcaata aatacttgac gaatggatga ttctctttaa 82680 ttttccttct cttgatacaa atctattttt gtttttaaat tcgtttggtt aaaatattgt 82740 taatttcttt aacttttgag agtctttaaa catgcagtta ttcctttctg attcttttgg 82800 tagttaaatt aattttttga ctgtttacat tagtttgctc ttttacttag cctactttaa 82860 tctaggggat ttgggatttc agcctgcatg ttccctttga ggaccgtaat tcttttctcc 82920 catgttccct ttgtgttctg ctccctttgt gcgtattggt ttaatgattg catctaccca 82980 gacacattcc aaaatcaggt ttccaagtgg cacagaatgg acagaatagc ttttgtcctc 83040 agtgctatca gagcttactc actgatcctg ggggtgcttt ggcaaggtcc tgattatcag 83100 gctgtctctg gtcactccca ccatcctagt cgtataggct gacataaagc aaaaccctga 83160 cagtggtcac tattttcttg accactttta cataggtgag aaatctattc tagcccctct 83220 ttaggcctgg ttgtattctc ctattctcct ttattcatgg gaagactttt tttctttttt 83280 cttttctttc tttctttttt tttctttttt tcttttgcct ccgttgtact aagataaact 83340 cccagttacc tctacctatt ttgggacctg gaatgcagaa ttgtcagttt gtgtcttcag 83400 cacacttact gatttgcatt ttaaaagtag ctaagtctta caattcaaaa aaaatgatta 83460 tcaaagtcgt gcttagaaca gaagggttgg gaggaaattt aatgcaagaa cttgactaag 83520 tttttaaaat gttaaatata atacaaatat agaagagtgc ataaaataag tacacaaatt 83580 agcaagttgt tataatgtaa acaccatgtt aaaaataatc caaatcaaga gatttaccag 83640 cacccaaagt tcctctcatg ctccttctgt ttttataact acggtttgtc tctattgctg 83700 tgtaatagtc cattctacca gagatcagca aaccatggcc tgggagtcaa gttcagctca 83760 ccacatgttt ttgaaaacaa agtcttgtta ggacacagac ataatttttt atttaaaaat 83820 tatttatagc tttttttttt ttttgctaaa atgaccaagt tgagtacttg tgacagaaaa 83880 catacggctc agaaagccaa aagtatttat tatctagtcc tttcagaaaa aaaattgtca 83940 ctctcctctt tatatgatta tatggtaata ttttatccat tctaatgttg ttaaagatgc 84000 agattattat taacttctga tagttcatta aatgctacta aaataattca tcttcacttc 84060 tcttggatca catatctgtg tctctgtagc ggtatattta ggaaaggaat gactgggttt 84120 ttggtacact taccatcaat attatgagac aacgcaaaca gttttccaaa gtcatcatat 84180 catatataca tatatatatg tattgcattt ccactatgag tgtgttagag tgaactttat 84240 tctacatcct tggtaacact tgatattatt gaatctttta attttagcca ttttgatgag 84300 tgtgtagttt taatttcatt ttccggttgg ctaatgagat tggttatttt tttatatgtt 84360 tattggccat ttagacattc tgttttgtaa gtccatattc aaattgtgtg tttgcttttc 84420 atctaggttc cccttttact tctaaatttt gagagtacaa attacctgat agtgtgtcaa 84480 atttttcccc actgctatat aacgtcatat ttgtaaacaa acaaacaaac acctcaacaa 84540 atacaaattc atgggtccat ttctagggct ctgtagcttg tttcaatagt attctgtcct 84600 aagtcctgat acccagagaa gcaagtcctc ctgatttgtt cttcaaaaat atcttggatg 84660 ttcttgaacc tttatctttc catattaatt ttacaattag cttttcagtt tacacatgca 84720 tacacacaca tgcacacacc ctgttatgat ttttaatgtg gattaacttt ataggtcaat 84780 ttgaaagttt tcaaaaaata tttttgcttt ggcttccagg aaactctgaa aaagattttg 84840 attaatctgc atatttgttg gaactttcta tgtccttgac cttttattcc actgtttcat 84900 gtttcctaag aattgcctga aattatgtgt ggagggaagc aaggcatatt aacaatttac 84960 aattggagca ggagcaggag gatgtggtgt aactcagtac catcaatgtc tatctgatta 85020 ggactatagt cttaaaacct gtgttacttt aaaaatacag atataatttt tagatccaaa 85080 gcatgaagat attaatgctg gcaggcctga aatttgactg acttatcaat atttttaaaa 85140 atcttagcag gtgtttctaa tagataagtc taggttgagc attgctgggt taggatgttg 85200 tatagagagc agggcctctt gaaatgctga tagcagcatc ctctctggcc ttgaacaata 85260 catcaagact tgtgtttgga gtcaaagtta cttaattttc aaataaatga attatgagta 85320 tatacgccta aatctttgtg tactatcata aaattctgcc accctatgaa gatggattga 85380 tgtgaacatg gcagttggga cttgtctcct cttattttta tttttttgtg catgaatata 85440 gtcctaacaa ataaatccca tccttggtga acaatttaat ggttatgttt ctgttctcac 85500 tgaacaaaca cagaagaaat atgccagact aaattaatga agtgaaaacg atatattcag 85560 taatcccata cattttctaa tatagactaa aaacctattt tcttccatct tatcttcaga 85620 cataatggta tgaggaaaaa aacaattcaa agaggaagtc tttaaggcaa tttctacatg 85680 aagtaacatt tgttgggttc atgtgtcaca taacaggcat tccacctttt acaattcaat 85740 ccctttaagc ggcttatgaa ttaggcagct atttctattg aaaaaatgaa gataataaaa 85800 tcagaaaact taaataaata aaaagttaca ttcagtgaat gaataggagt agagtctgga 85860 tttgaatctt gcttttggct tttgtgtgtg accacatgtc acattctttc caccacccac 85920 agagacaaag cgacattcac attgaaggtg taagagatgg caatgaatcc atgacctcag 85980 agaatcactt cactgctgca tgaaatggat aataattatt tcttctcctt tcgctggatg 86040 ttgtggctta attcacattt gtaagatgtt atggataaaa tcactgcaat cgctaacagg 86100 catttatgtc ccacagtctc tttgggcttc ttgcctttta tcttccagca tgccatagcg 86160 atggtgctcg ctggatttat gaacaccgtg actgtctgtt tggaacactg agatgtgaaa 86220 ttgcctccac attgaacaag atttggctct tggtggtagg agggttgtga ataaagtgag 86280 cactggtggt acagaggagg acatgctgca acattatttt cagtaataat cctttagtta 86340 ccaggaatga tcattttttc tgattcattg tttagtttga aaacaattaa caactaaaaa 86400 tatcatacat ttaaagataa tatttaagta aaatatttgc atgtagaata aaggttttta 86460 cttaccaaat aaaaatacta caccttgaag tttgcattct gctttactgt tttacatttt 86520 agacagaaat taacatttga agtggtcaca aagaatgata gaatgaaagt cactcatatt 86580 ctgtttgttc ttctttacag ttaagacatt atctggttta ttttgactgc tgtttagaca 86640 tgagaataat gtggtcctac aggctctgaa gacatgaact ataatgcact gtcctctaag 86700 tgagctcaaa tgattctaac tccttaccaa ctgaccctcc aaacaaacac ctgtagctga 86760 gtctgtattt gtcaggggcc aacagtatga ctgggagttc ttaaagtaat ttgcatgtgg 86820 aacataatgt ttattatagg ataggtcata aaaatgtgct catttgacac agagaaatgt 86880 aatatcagat ctcaatagca gttaaaacac tccctagaag ctagaccaaa aaaagatttt 86940 ttgaggagaa atatttttct ttgacattgt ttataattgg tgaagcacag caatgacaag 87000 tagctgaatt tcagttcagt gtttcctttt ttaattatct acagacaatg aacatccttg 87060 ctgtctgcat gtgggatgga tcacttcacc ctgtagccta acagcacttt ttctgtgact 87120 gttatcacaa tccaagagac cttggagaaa agctgctttc ttacataaaa cactttcaaa 87180 gaaactgagc aaagatgcta agtgtgcatg gcacatggca agggtgagca caaatggatt 87240 caggcttcct tggaaaatca agaggataga gtgtgttgac caaaatatct gtgaatggat 87300 atagggctag aggagtctgg tggggtcatg tgttgcaaaa gaaggggagg tgcccattct 87360 gaaatgaaaa aagttaagtg aaaagtctac ttatatgtga ttcagggaca gagggaataa 87420 ctgaaaaccc tccctctcca cggaggctct gggctaagtc agctgagtgt tgtgagtcat 87480 gaaagccgag atttggagag tccagtgtaa gaaagcacag ggcatgaatg ccacaagcac 87540 attcagtggg ggaagccagg tagacactga agtcagggca ttcaggggga tgccagcaga 87600 gagacgtgga ttaggaaaat gatcataaga taaagtctta agcagagctt gaattcaagc 87660 tctgccattt attagctata tccttttggc cagtttactt aacctctctg accattaaca 87720 tcttcagttg caaaatggag taatgacatc tagtgtttct gggattgttg caaatataaa 87780 agaataatat atgcaaacct cttgccatgt tgaaggtatc taggaaatgt tccctatcta 87840 gctgtggcag taataaaaat aagcatgcaa agccacagcc agacctacag gaggagccca 87900 gagctatgat ggcagacttg ggagaagctg gaagccaata gagaggggcc cctgaatgac 87960 tcttgttgtt gaaaacctag gaccaaagtc aggagaatag atttcagctc tttccttgcc 88020 actggctggc tgtgtgacag atggtttgct agttgtcttt cctgggcctc ctttagtttc 88080 ttctagagca aggttattgt tattgggtca ctttgtacca gtcattttat caccaggaat 88140 attttggtcc cgataatatg aatgataatt gtccccatgt ttaagctatg atgttaaaaa 88200 catgctacct ctttttggtc tgtttgccta cctccatgcc caatccttac cacacctgac 88260 cctatgctgt cctcactccc actgcacccc agagccttgc ttacccttcc acccaggtaa 88320 ggtgcaaaga ttccatggaa ctgtgtttcg ggcccagtag ttagtaacaa gggaaagaaa 88380 atgtatcaaa gattcattcc ctagatggtt gtgttgttga ggtgggagaa tcggacttcc 88440 tctgggtaga tagccgtcag ggataaagaa agctcaggga catgtttagg atgctcactg 88500 caaaaattat ctaataataa aaaaattcac acataaaaat aatggttttt agagtcccaa 88560 aatggtggag tttttatttc cctggttttc tttaaaaagg cacattttta ttttctatct 88620 gtccatttag tcattcatgt atttaacaaa tatttattta gttcttctta tgcccttggt 88680 gctgttttag gtgttgggga taaaacaaga aatcaacagt ggatacaaca ataaacaaag 88740 agataactac ctatagcata tcacaggtat tccaaaagca ataaacaaac caggataaat 88800 agttattgac gtgatggtaa agctgcgtat ctccaaattt cagtggctca tagcagcaaa 88860 cattgttttc tcttgcacag tggcttgtgc ttggctggag tgagtgacct caggctgctt 88920 tcacactgag ttctgctcca ctgtgcttat cctccttata ttagcagcca ccggtgctgc 88980 tagtaaatgt tctcttcttg tagcatgata ggaacacaag ggggtgaagg gaaagtcata 89040 tggcttctta ggcttcaaca agaaattgca aaattctatc tgaggcccac agtctagtag 89100 acaattcatg ccacgtggat aagcccaaga tcaattggga tgtgaggggt acagtcagtt 89160 catagtgggt ggtactgcaa tgtcatatgg caaaggcata aatgcgttat tctattaagg 89220 gaaggagtaa agaactgaag acaacagtgc aatctaccac acagggaaag gatgatgagg 89280 aatgtcaggg taaggggggg tggcattttg tatacagtgg tcagagaaag ccttcaccat 89340 agatgacata tgaccagaga ccttgaggag gtgagctggg taagtaattg gaaggagagt 89400 attacaacag agaaaagagc tagtgcaggg gtttgcttga gaggtcaatg gggccgaagc 89460 agtatctgag ctggaaagat ggaggaggta aagtccaagg tatattaggg gaggagcatg 89520 tgtgataggg ggctgaagca ggtaatataa gcccttataa aggtttcagt ctttactctg 89580 aataaggtga gaagatattg ggggactttg atcagaagaa agatgtgaat tgataagtgg 89640 taacaatata actgatggat gtattgagag tgcatgcaga gagaccaagg tggaaggaag 89700 cagtacactt acaagtttat tgcattgatc cctatatgga ctgatgatag cttggtctac 89760 ggtggtgaga aatgataagg ctctggatat attttggagg tggtgatgat aagatttcaa 89820 ggtgtatcag atgtaggata tgagagacag aaaggagtca aaggtgattt ccaaatgttt 89880 ggtttgagac tggaaaggtg cattgccaaa aaataaggtc aggaatattg tcagccacga 89940 tatttagaaa atctgattct cattggtgag gataggaatc tttcttcccc tgctctgcaa 90000 tgctgagaag tctttatgaa aacaacgcaa gtaccacaat aaaatactat tcaggttttt 90060 atatgttcca cttaaaccaa accactgtat catataagct agaattatgt ccacattaat 90120 ttttgttgta ctttgatttt aaaagtcatg ggaaatggat cctagaaata aataattcat 90180 ggaaactaca ttattaagtt aattctaacc aatagcatgt cattaagata caaatgtgaa 90240 aatagttcaa ttttattttt taattaactc ttcagaagta atagccgaca attgtccttg 90300 atcaggtcaa atgctgtttt taaatgcctg acagttttta agtctttaat ggaaatcaat 90360 ggcccaactt cctgaaatgt attaattaca tttatctttc taggcagttt ttagtaagga 90420 ccaggactta aaaataactt ccaaacattc tctggctaaa gtctattttt ttcttaataa 90480 attcacagtg ggcatttact attctggtat cttccccaca atatccaaac tttgttcact 90540 aattcctttt ccttttctct ctacatccat ataccacttt atctttcaag catcagcgta 90600 aatcccattt cctacattca gtgaccctgc ctccaactca cactgatctc atatacttca 90660 atgtgatatt ttatatggaa gtcattgttt tttgcataag attgcaaagt gatttggaaa 90720 aaaaaaccaa aaaccttggt aagcaaccat tcaacaaata ctgcattttt gtttttcatt 90780 tctcattttg tatccctttt tatactgatt ctcggcagga gtatccaaga gtggaaacat 90840 gcaaggtttc agaatctttt gcaacttaat taggctctcc gtggaatatt ctgaatccct 90900 ggaccattgg agcagctgaa cctggagttt ggaggaaaga tgggactggg aggcagcgag 90960 tggggatgaa ggagcagcct gtgtcccctt catttgatgt ggtcctggca tgctatataa 91020 aaggagtggg gattgaggcg tcagctgttt tgctggtgtc catggcatca tttactggat 91080 gaaacttgca ggacgctgag gtttggacag ggaatggctg agccaaaact gaatcttcct 91140 tgctaatcgc tgtgcacaga gaggataaat acaaatggat gcaccccaag aggcagtcac 91200 tgtcattgaa caaagggaaa ttagttaatt attgctatag tccatgaagg agggatctgt 91260 ctgtcctctt tccaatcctc tcctcacaac agtggtagta gtaggaggag gtgagatgtg 91320 gaaaagcaga ccccacctcc cctccatgcc aggctgcatg agctgcaagg ctagtcatat 91380 ctggaagttt taaattgaaa ataaaattaa agttagtaag tgaacaacag tgagccagca 91440 ctttgggagg ccgaggcggg tggatcacga ggtcaagaga tcaagaccat tctggccaac 91500 ttggtgaaac cccatctcta ctaaaaaaaa caaaaattac cctggtgttg tggcgggcac 91560 ctgtaatccc agctactcag gaggctgagg caggagaatc gctggaaccc aggaggcgga 91620 ggttacagtg agccgagatt gtgccactgc actccagcct ggcgatagag ccagaatccg 91680 tccccccgac aaacaaataa aataaaataa aataaaataa aaaagaagca ataactcttc 91740 cagtaatcaa aaaagtctta attttatgaa ctcaggatga gattgtgtta agggaaccca 91800 ccacccagtg agaaatgatt tgaccaaagg cagatagtgg tatctgtcag gacaaataaa 91860 agcatctcat gcttatagcc caataagtta aattttctca ttaaattggt gattttctga 91920 agctagtttc cttctttaga aaaaaaagca ataataacaa tctgttatta ttactatgat 91980 ccactggctg gtaatcatga gccggacgtg ctgactctct atacctagca gtctcaaggg 92040 cacctgtgag cggtaaaatg gctttcatcc atctcacaac acttgaactg tgcacatgtt 92100 tagcgaacaa atgtttactt ctcacacttt gtttttatct gtagtattcc tgtaagctgt 92160 gaacaggaat tcctgtaggt gtgaacactc caaggtgcca tacacttagt ttgacatcaa 92220 aggaaaacta ctcttatctt tccccttgtg gtctttgttc tgcactgttt gtctcaacac 92280 cacatacttc cctcttatac cgccaatgct cccaactttc tcaatcatta ttcatcctta 92340 aatttcaggc cttggtgttc ctttccgctt gacacagatt tcctgcataa aaccttggct 92400 tctcttcaat caccatacag gttttctggt agtcttacac tgctgtaggt aaatattatt 92460 cagttctatc caacaaagta cacccaccag ttctgttcag gtttgttaga agtcaattgg 92520 ttatgagtga tttttctata cagtcatatg taccaaattc tctcttatgc attgctgaga 92580 agtattatag tctcaatact cacactgaaa aagttgcttg ctacttctca tctgcctgtg 92640 attacatgaa aaagctttgc atgtaggtca gaaacaggga aacataagga gccaacactc 92700 atttctaaca ttaatggaat ggagaataag gacattcagt ttagttgtaa ataaattaaa 92760 agaaaataat ttaaaaagct attgtcttca gcatttaaag ttttctcaac acttgctcag 92820 caatgctatt atttctcaga ttctgaaatg gctaccctct tatcatttta atgtaagtga 92880 ctttctgtat ttctttctct ctttttaagt agttattctt caggaatgaa catcaggatg 92940 caaagaacaa ttcaccacct aatcagtcat ttatggcaga aactgaatca aaatgattag 93000 acttagtgac tctgagtgta tactttgatt attgcttttt caatttgacc tactgaagag 93060 aacattattt tatgcctgaa tttactttgc tctacttttt tagttaaagt cttataaatt 93120 aaaaaaggca tttaatagaa ataaaatata gttatattgg catgagggag attttccata 93180 taaatcgatg gaaagaaatt gaatcaacac ttacaaacaa cattgttttg gttatttagg 93240 attacgttta cccactgggc tagcaagtag atgacatttt gcctcatatt tgatattcga 93300 ctaattcttt tttcagtgtg gaatgaggca ggtaaaatgt gcttaagatg ttctaagaag 93360 tcacaaggta ggtaaaaaat tgtgatcttt gaaattggcc aaatctgtat ttgggttcac 93420 atttcatcac tcaattgttg agtgtctttc ttgaccatct tgttggacca ctctgagttt 93480 cactcttgct gttgaactga ggctaataaa cccttctcct caatagacat tgtctacaag 93540 gtgagcagtc aaaggcattt atatgctatg caatgatttg aagcacactt tcaaatatat 93600 ggttcaaaac aaactcacga tgtatatatt atattttgtc atcactcttt tgagctgatt 93660 tgatgagagg cattttaatg tagccaaaat aaacaagcca ttgaacatta accttgatgg 93720 acgatgcaac tcaaactaaa agttccttga gaagtaactg atctgctcaa ggtcacacac 93780 taatcaggac agaggcaagg cctgactctt ggtctcatga gctaatattt atttatgttg 93840 accatgcaag ctatatccaa aaatagtaca gaattttaga gaattttaaa ctctgtcata 93900 gatggatgtt tgattaatcg agcggactgt ttttgtttaa tggaaacaat taaaattatc 93960 tttctaaaat aatatattga aactgactca caatactaag ttatatgagt agaatgacat 94020 ctgttatagc cacattctat ttattatctt taatatatta ttttaatata cttgacattt 94080 tatttactct ttaagtaata aatatcaaat aagagcaata aataaagctg atttataaat 94140 tactgttctt ctatatgagt taagatgcag tagaatatac cctcttgaga ttactagact 94200 gggttttagt ataaaacatg agtgcaattt gcccacatag ataggttatg ggaagatagt 94260 tttgaaactc aggaagagtc actctgaaga attgagactg gagttctgcc aagagatgtg 94320 caagtcaaat ggaattctgc aactccagag agggagagag agagtagagg cttggaagga 94380 ggaagagaca aagttttcag ttctcactag gcacagttga aatttctact ctgtgttttc 94440 ttgaaattta agtgactctt tccaatcgac tcttatgtaa gtcagtctga atcacttttg 94500 gtctttgcaa ccaaaggatg tattaaaacc atcttttgct tgtcagttaa acatatggct 94560 gttgtttaaa tgtaagaatg gagagaaaag gtgccacgta attcaggagt ctcttcatct 94620 ttgtcacaga gccttgaact atcttcccaa taaatatttg atttgaatct tcagcactga 94680 ggggaagtgt cttctgaaat aatacaggct aaattgttat gtagcagcca tctatacaaa 94740 gcaaattttt gtaatataca aaagagggga ttttgctatt atatcagttg gcaagaatca 94800 ttatcgtgat tggaaataaa tagatacaga gagaaaagaa tgagatttaa aaaaaaaatt 94860 cagcttcaag gaaattggat tttctgttga gtatggaatc gagactttgg aaactaaaag 94920 gctagaaaaa gattgcttta ttaagaaaag taaaaataca tttttttcat ttgaaaaatg 94980 cctactagac aataaaacat ctggctaaaa aatgaaatct tcagtgacac atctggatat 95040 ttgctccata agatatcaaa catgaggata attgaaaata tagagctaaa ttacttaaat 95100 gttaagctcc catccagatg tttgatgcta tgttagatga aaaaactctt tacatgccag 95160 acattaaagc aatcagggat atctaaatgc caccataaat aaaatagcat tgcaaatatg 95220 gttcactgga aagaatgtat taactgataa ttacagacta cacaagaaat ttgcttctta 95280 gttaaaagtt tttttaattt ttttatttta ttttattttt ttccttctga tcagtagtaa 95340 ctaataaaac atggaaacac gaaatagaca tccgtagacg acaactggtc aggcttattg 95400 acaaacaagt ggatttcatt tccaaactat ttttttacta tatatagaaa tatcaatgag 95460 ttagaggttt tggctcctaa ttagagaata taaaacttga tttttggaaa tgcattggag 95520 aaataggaca aaattttgaa tttcaattct ttggcaatat ttataaggaa taaaatccaa 95580 aatagatgaa actgatataa tttagcttca agaagtacca gatgacaact gaagttggct 95640 cacaaattat aatctatggg agaatgggaa gcagtgagag ttaaacagtc aaggacagca 95700 tcagtcgttt ggctgacact gcagatttat acagacacag ttttaaatcc aggcagatct 95760 gttagtgcag agaagaaagc actgtatctc ttatgtggtt caggcaggaa gcaagggtta 95820 taatctaggg agtcagaaaa gttaaagagt gccaccaagt tatgtgagtg gacagagttg 95880 aatgttgcct caaggacaaa aaaacaatat cttctctgtt ctacttttta aaatggactt 95940 ttaacattta ggccacatta aaatttttgc aatcaagaca gattcatcag gatgttggta 96000 acaaattcta atacatctat tgtaagtgtc tactcaaaat gaagataaat attttaaatt 96060 ccatttatgt aagaggaaaa caggggctca gagaattacc atgacacatc caagagtaac 96120 actctgtcat gaggaagcag agtatgacta caaatccagg cctggctaat tcaaaagacc 96180 acactttttc acttgtcatg ctgactctta aaacatcaaa acctgatcag ttgctttggt 96240 ctgaactaag gtaaaaattg ctacagatga actgtttcct agattattgc tacacataac 96300 tctttcctag attaatgcag atgtgtagat gacacaaagt gacttgagca acaaatctga 96360 ttactgaaaa gatttaacat attgtacaga ctactgtgtg cctgaacaac agaaagtgct 96420 gaataacaaa aaaaaattgt aggtttaaaa catttaaaac aatcaaattc tttaaaacat 96480 gcatgtaact ccgtgatact gactcagtgt ttggcacaca gaaccctgtg aatataaaat 96540 gaatgcccgc ctgaggaaac taattttata tctatatcta catctttatc tatagataca 96600 tgtatatata tttttatcaa tatcaatatt tttcttgatg tcaaggtcag gatcgtggct 96660 ggtgtgtcag ggtccacaaa tgtcatctca ttcaggaaag tatttcaggc ttaggtcaaa 96720 ttgtcagaag catttgaacc aaagcaactc catcttaaag aggagcttgg taaaatgaga 96780 ctgaaaccta ccgggctgca tacccagatg gttaaggcat tctaagtcac aggatgagac 96840 aggaggtcag cacaaaatac aggtcataaa tacctggctg ataaaacagg ctgcagtaaa 96900 ggaaccagcc aaaacccacc aaaactgaaa tggggatgag actcttctcc gatcgtcctc 96960 actgctacac tttcaccagc gccatgacag tttacaaatg caatggcagt gtcaggaagt 97020 taccctatat ggtctaaaat ggggaagcat gaataatcca ccccttgttt agcatatcat 97080 caagaaatag ccataaaaat gggcaatcag cagcccccag ggctgctctg tctatggagt 97140 agccattctt ttattccttt acttccttaa taaacttgct ttcacgttgc accgcaggct 97200 cgccctgaat tctttcctgc ctgagatcca agaaccctct ctgggggtct ggatcaggac 97260 cactttcctg taacaaaatc aagcatcttt ccagacaaag cgtggtttta cccattctag 97320 aatccccttc ttaatttata aggccgagac aagtgtccag gtaggcctta gctgcctggt 97380 gaatagtaga gaaacagttg gaattatatc tgcttggtta aaatccaaga aagcataagc 97440 caggagtcaa ttggaacctc tcagctctta aaagtaatat tggaatattt tgttccagta 97500 tttatctatt tcactttgca ctgcaggctc tccctgaagt ctttcttgcc tgagatctaa 97560 gacccctctc tgggggtctg gatcaggacc cctttcctgt aacaaaatca agcatctttc 97620 cagacaaagc atggttttac ccattctaga atctccttct taatttataa ggctaagaga 97680 agtgtacaga aataaacttc tttgatagtt tttagctgca acagaagtgt gggatggggc 97740 agtggagtga agagggaatt gtgttttagt ggtgaacttt ggatcagaat ctggcttctg 97800 ccgatttgtt taattgctta actgattttt ttcttttttt tttttttgag acggagtctg 97860 ggtctgtcgc ccaggctgga gtgcagtggc gcgatcttgg ctcactgaaa actccgcctc 97920 ctgggttcat gccattctcc tgcctcagcc tcctgagtag ctgggactac aggtgcccgc 97980 caccacgcct ggctaacttt tttgtatttt tagtagagac ggtgtttcac cgtgttagcc 98040 aggatggtct cgatctcctg acctcgtgat ccgcccgcct tggtctccca aagtgctggg 98100 attacaggcg tgagccactg cacctggcca gttgattttt tttatccttt tgtgatgcct 98160 gaattttggg cttgaaaacc cagatgtcaa atacaccctt ttctttaata tttgcagaaa 98220 gtcctcattc atagacattt gtagtttgcc gcttttatga gagatacagt aagaggaggg 98280 ggtggaagag ggggtactca catctaaggt aaccatccca ctggcccact tttggccacc 98340 cattgtgaga acttttccca tgccatctca tccctagcct tgaacctgct cccgctccac 98400 tttctccctt ttcccttcac cagtcctcct cttttttcta tatcttcctc tcattttcat 98460 atgcagtacc acttattcat cttttgtttg ctgctggctg ttgttttgaa ggttttaagt 98520 tctattgcaa ggtgcttatg aaatagtttc ttaaattaaa aaaaaacttc taaagtaact 98580 ttatggtgca actattattt tatcttattt tataaaaatg atatttttgg ggactaggca 98640 cagtggctta cgcctgtaat cccaacactt tgggaggcca aggtcgttgg atcacttgag 98700 gccaggactt ccagaccagc ctacgcaaca tggcaaaacc ccgtccctac taaacataca 98760 aaaatcagct gggcctcgtg gcacacgcct gtaatcccag ctacttggga ggctgaggca 98820 ggagaattac ttgaacccat aaggcaaatg ttgcaatgag ctgagattgt gccagtgcat 98880 tccaccctga gcaacagagc gagactctgt ctcaaaaaac aacaacaaca acaacaacag 98940 atctttttgg tattcaatca ggtattttta aaccatattt aatacatcta actagtaact 99000 tttagatttt atctcattaa tttaagtgtt ttgatgtctg aatatttaac atctggacaa 99060 aatggcttca gtaaaggcag gtgtatacag tattttgtgt aattccatta taattctatt 99120 ttttccagtg caaattcttc aatgttctca tcaaaaaagt tatctatgga aaggaacacg 99180 gcttcctttg cattctcatt tgaagcagga agtgtgaaag accgcgctag actcagtaat 99240 tggctgtcat acactattta gaacgctgct ttgaagaaga cctgcttcct cctttactct 99300 tctctgtttg caccacaaaa tattcaaatg gaaagatcaa agtggaatgt tcatttttat 99360 tgcctctatt tcatgtgtga tacttattct aatccttctt ggagtaaggg tcaaagattg 99420 ggggatttga aacataaaac agaatttgaa gggggatgga ttgagtctgg tagctgacca 99480 ggagactgac ttaaattaga agaagctgaa ctgtagtatt caaaatacag gtaaaacttg 99540 taatgttgtc tttatataca tgaaagcagg aattcatcat gtgagataat aaaatgcaag 99600 gtctggaagg aaaaaaaaaa catgagagaa agatatcctc atgaatttgt ttactgactg 99660 cttggtgaag ttatggatta catgcctgca gtccaaaatg gaattctgcc tctgagagct 99720 tgcctttgcc tgacttctaa acacaattgc ctggaagaag atggtgatgc gtctgtaagg 99780 agactggttt tacaggaagt gttacttccc gtcacactaa ttctcctgga gctaacattt 99840 caaacacttg cacttatagg ttatttctct ttgtagaaca gaaatgagcc ttcattttgg 99900 ctaccagtac tttagaatac ttggtgaaaa gtttctttct ctccctctct ctctgtctct 99960 ctttctcttc tccacccttg cccatcttct ctcttaatac attttatttt attttatttt 100020 attttagaat cttacctgga ttctccttaa aaatggtgca acataaatat atactcaatt 100080 ttgtttttct ttgctgcata aaacagtttt ttttaattaa agagaaatag ctataagtgg 100140 tctaccatca acaaaaacac aacaaacagc tcctttgtac cactgtcatg ttgccttcca 100200 tcttacagtc ctcagtttct tactgctcac ccccagtggc catagatgaa actaaaatct 100260 ctggatttcc ctggtttgtg actctcaact ggctcagcta gcagggattg ggcactggga 100320 taaagcctcc cattttctgc tttctttgct attcttctct gagttggtct ctcagctgtc 100380 tggtaggagt cagcatgggc acattgggta ggtctcagga aggcatatct cacaagaagt 100440 ctcaggacac ttctctaatg aggcatccgg cagagttatg aatggagcca gaaacgactg 100500 actgggctgg agaggggcac ctggcgattg gcagagcagt caaaggttgt caaaatgcac 100560 aggctggaat cagattgcac ttgatatctt aggaccgaat gtttcatgag ttgagatact 100620 gtgaagaaaa ataggtggag aatatttctg agcaattggt tggtttacag gattatttcc 100680 cacgtctttt ttataacccc tctttccacc tgaaaaactc ctagttaacc ttcaagattc 100740 tgccttgcct gatacaagaa ttaacttggt tgctccattc aggtcccttc aaggaaacgt 100800 catattgcat aagtgcccca attgatcctt ttaatcatga cctggtcacc taggtgtcca 100860 catcttccct tgacctcagt cttttccctg tgtttccagt gcaatcacag ttcctgatat 100920 gaggattctt aataaatagc tgctgcatga atgaaaaaca agacatagag aggaagcact 100980 tattagattc cagactccct gctatgcatt ggggattcaa caacaaatgt cacaaacttg 101040 ttccaaaata ttatttgtac agtgaggcct gtttattgcc tggtatgggt actgttggca 101100 gatacggggc ttctgggtgt ttaggaaagg tcaggtacct tcttcctgag agttttagaa 101160 agactgtgtg gtctattttt taataggaag ccttaagagt ggagtccagc ggcacatggg 101220 aaaatataac attgaaacta ttggaaagca tggcatcaat gtggaaaaac ggggtcctac 101280 attgcaattt aagttgttgt agatgaaaac agtaaactct gaagagtggg gccaacatta 101340 acctgctggt aggggttcct ctcaaggtca ggtagccctg agatttatgc taaaggacaa 101400 ggccagtgct taccacattt agcaacttct ctctcggtga gtcctagttt agcacgatat 101460 tgccacactc aacgactcga ccccacgatt tcaaatggca accccgttga agtggatatg 101520 gagttttgct tctgtatgtc cattgaaggt catgtatgaa gatgttacca atgttaagct 101580 attctgaata tccccagtat ctcttcaagt gcaaaactta cagcattata aaataagggg 101640 aagatatacc tgaaaaaaca tgaagatttg gtaatttaaa aaaaagtttt aaaaacaaaa 101700 attgcttaat taaagtccta tatgaattta ggcaaaatac acaaactagc tgatctccag 101760 attccccata tagatgacag gcaaagaatg tctacaatta ttgataagat taaatgagat 101820 aatgtgtata tttcttgcac attgcataaa acttcaataa acatttgcct acctaaattt 101880 ccattttctt tcattatata cctctgtata aggcccagtc agaatgcctt tccagatata 101940 aagcatggca ataactagga aatttggaat actggtaaaa atttcttgta tttttctttc 102000 tttctcttta tggggttcca tcaaattttg ctggaccatg tcacttggat atttttagat 102060 gagaccttaa aaaagtcata tatgggccgg gtgtggtggt tcatgcctgt aattccagcg 102120 ctttgggagg ccgaggtggg tggatcacct gaggtcagga gttcgagacc agcctgggca 102180 acatggtgaa acaccatctc tactaaaaat atgaaaatta gccaggtgtg gtggcgggtg 102240 cctgtaatcc cagctacttg ggaggctgag gcaggagaat tgcttgaacc cgggaggtgg 102300 aggttgcagt gaactgagat cacaccgttg cacaccagcc tgggtgacaa gagtgaaact 102360 ccatcacaaa aaaaacaaaa aaacaaaaaa aaaccaaaaa agtcatatat gttacgccaa 102420 atatggctga taaaactgaa gaggttgaac atgtaagtag tagttgtgct cagacattag 102480 agtgcctgtg aagaactaca aagcttgcta tcgttttata catttgttat ggtctgaaga 102540 attgtatttc ctcaagattc acatgttgaa acctaacccc caaggtcacg gtattaccag 102600 gcgaggcttt tggctgatta ggtcaagagg gctctgccct taaaaatgaa attagtgccc 102660 ttgtgaaaaa cgcttgaggg agcttgttca ccccttttgc catgtgaaaa tgcagcaaaa 102720 tgtgttatct acaaggaatg ggcccttgcc gcatgttgaa tctgttggca tcttgatctt 102780 ggactttcca gccttcagga ctgtgaacaa tgaattctgt tgcttataaa ttactctgct 102840 tataaattac tctgcttata aattctgttg cttataaatt tgttacagct gcctgaatag 102900 atgaaggcac cattcgagtc tctggatttt actttcccaa aattcagtga gttccagtat 102960 cattctttga gaaatccaat aattgttttt aaccttaaga ttaacaggta ggaaagtgac 103020 acacacctga aacctgttac tctagtggta gaatctcatg gtttgcaaac gtactgctga 103080 aaatatttcc tgcatatgaa aggtactctg aagcccctca gaagacacca caccacccag 103140 actgctacta gataacatag actccaagaa tggcatttgc taatgtgtgt ataaaatggc 103200 attttagaat tgcctaaata tccttattaa cactttctaa agaattgctg ttaactcttt 103260 taaaatcaat tagattgccg aaggaagagg gaggggatag gtttaagtga ggtactacat 103320 cacatagtgt tggatacatt ttccaaaaag ataaatgtaa gtctttttga acacataatt 103380 tttgtggcca tattgtctct gaataaaagg acaattgggt tgtcttcaat ctggagagtt 103440 ctagttgttt tcattttttt tgcctttatt ctccccagtt tcttcatgat gatgcatttg 103500 tttatagcct gcacaccaca tctgatacat ttttaatctt tagtgagcca tgacaaactc 103560 agaaatgatt agaaattcca aaagaacatg ttttttaact tcactgagta cttttttttt 103620 ttatttcact ctttgttttc tttggaaaac aaataaaatg tctgcttcct cttagccata 103680 tctctctaaa gtgttctgtt gtgtgtcatt agccaacagg cagctgggta aatgctggcc 103740 cacatccaaa atgatgattg cttttcataa gcactgtctt tgctgttggc tttctgacta 103800 atggcttctg cttgtaatgg atacaatgta gtatgattaa ctctcaggtg attaatagat 103860 ggtgtttctg agaactaaat aatgaagaag caattaaaca aatctgatat gctgtcttta 103920 ccacaaatca aataacactt tttcttccta ttccttggac agtggtttgg aggtcataaa 103980 gctgttctga ctcacaaatg ggagactttg gcaattgttt taggataaat aaagacagga 104040 aacatagtac accctcttca ccatcatact cacctgtgtt tgagattttg tagtgtgtga 104100 tatgaaaaat aggtgtcatt taatccgtga gccccaattt cttcatctct aaaacagtga 104160 ttataataga taatttgtac ctttaaatga agattaatga agattaaaca acacaatgta 104220 cacaaagcat cccacaaaaa tgccaaatac atagtattca gttaatatat gttggtttca 104280 aatacctccc tttcttctag ccttagcact catttttctg gaagcaaaga atattaggag 104340 ataggatgag gattgtcaga aactttcttt tcttctctga ccttcagtaa ttcagaaaag 104400 aaaaagattc atccctctac taacatgaaa ataattgcca tttgcagccg tgataatcat 104460 tttaagttat tagtattaaa aaaggcatat catagattat cgtatttcta gcctccaata 104520 tcaatttcta tactccctgt tacttggcct tggctgtgta gaattttacc atctcactag 104580 aaataataaa cagcaaacat caaaacaagc aaaaacaagt aagcaaacaa attataggta 104640 attaatatat tttatacttt aaacatttga agatggtgag tttttttttt tatttttatt 104700 ttttgagacc gagtcttgct ctgtcgccca ggctggagtg cagcggctcg atcttggctc 104760 actgcaagct ccgcctcccg ggttcacgcc attctcctgc ctcagcctcc ctagtagctg 104820 gaactacagg tgcccgccac cacgcccggc taattttttg tattttttag tagagacggg 104880 gtttcaccgt gttagccagg atggtctcga tttcctgacc tcatgatccg cccgccttgg 104940 cctcgagatt tatttttaaa cggcagaaat aggtggctaa tttgtcttgg aacaagtaac 105000 accttttgct tggttatgtc tcatgaacaa acaatcccac aatctcagtg gcttatagca 105060 acaagggcta acttcttgct cacgtcatac catagctgaa atcatttccc aattttatct 105120 tttaccggtt ggagatgaga aataattaca cttattgaac ttgctaataa atttgttagt 105180 ctttatctgc agctcccctt gttttctcaa ctttatgttg aagtataatt tacgtatcat 105240 aaaataaata gttaagtatt tctattaatc agtttttgta atagcatgca ttcatgttac 105300 caccacctaa acaacagagt tttttccatc acccacaaac atattctttg cttctttcca 105360 ttcagtctct gctgaggcaa cttctactgt ctgttagttt tacctacttc agaagttgat 105420 ttaaatagaa ttctacaata tgtgcttgta tatgtctgac tctgtctagt cagaataatc 105480 tgtgtttttt acattcatga tttgtatgta tcagtagatg acatcttctt tttgctaagt 105540 agttttccac taaatgaata tatataacat catattttat tttcttattc ttttttgatg 105600 accattagaa ttgtttacag gtttggacta ttatgaataa gtcttctgtt aattttgtag 105660 aagtcttttt tacacgtttt tattcctctt gagaaattac ctaggagtag aagtggtgaa 105720 tgatagagta ggtgtatatt tgactctata aacaactgcc aaactgtttt ccaatgtggt 105780 tgtgtcattt tacattgtta ccagcagtat aatagagttc tggttagtcc acttttcatc 105840 atctttaagt tgtctttcat tatctcaaca gtgtctttta aagtgcatag gcttttaatt 105900 ttgacaaatt taaatttacc agtggtggtt tttttttttt tttaataaat tgggcttttg 105960 gtgttagttc ttagaaatct tttcctaatt cctgctttct tccagcagat ttttagtttt 106020 tattatttca tttggaccta cgatataatt tgagttaatt tttgtatgtg gcacaagaaa 106080 tgaatcaggg ttttacttgt gttttcgttt tttgggtttt tttgtttgtt tttgcttttg 106140 cttttgtttg cttttgcaag tggatatgct attgttctag caccatttgt caaaagatca 106200 ttctgtcttc actgaatagc ctttacatct ttgctgaaaa tcagttaacc tatatgtgtg 106260 agtttctttc tgcaatctgt attctgtttc attaatctgt ctatatatat aacaaaacac 106320 gctgtctttc ttactataag gcttgaaatc agatagtttt caaacttggt tcttttttct 106380 ttttttaaag ttgttttggc tagtctagtt tctttgcctg tccaaataaa tgttataatt 106440 aacttgtcaa tatcaacaat acaatcttat gtggttttta ttaagatagt attgaattgg 106500 gattgtataa agatgaattt gaaaagaatt aacatcttaa caatattgca tcttccaatc 106560 cataaaaatg gcatagctct tcacttactt tactctcttt acttttcttc cagcaatgtt 106620 ttgcacagtt ctttcaaatt tttaaatcac atctatccct aaatatgtca tgtgttttaa 106680 atggtacata taattttcgg aaaaaaacca tttttttaaa gtcatttaat gaaagtatat 106740 ataagtaaaa tttattttta taacttttta atttgttctg tatgtcttga aactttgatg 106800 aacatattta ttaattccag tgcctttgtt tgtagatttc actccatgtt ctacaaagat 106860 gattaatgcc attagtgatt aaagaaaatt ttagttcttc ctttctgatt gtggtatctt 106920 tttctcgtgc cttaatgtac tgatagggac cttcagtaaa gtgttgagta gaaatagtga 106980 gagcagaaat ctgtgatctg ttcttgatct tattaaaaaa ttcaatcttt taccataaag 107040 cttgatatta actgtggagt tttccctaga tgtctttttt caggttgaaa atgctccctt 107100 ctatttcgca tttgttaaaa gtttatatca ggaatgaata ctagaattgt caaatgcttt 107160 ctctctgtta agcggctttt ttctttggtg gtttagtaag atggtgaatt ttctttcttg 107220 gctgtcaagt gttaaagaat taatgtttgc agtcccaaga aaaatccatt tggttatcat 107280 gtactattat ttttatatat tgttgaataa atagcacttt ctaaaatttt tttcagaacg 107340 ctgacatttt attcataagg tatgttagtc tatagttctc ttttcttgaa atatctattt 107400 ctggttttgg tttctggatg atgctggctc atagaatgat ttggcagata atacccactt 107460 ttcagttttc tgaaggtttt ttgtagattt gattttattt cttccttgaa tgctggtggt 107520 ggcacttatt agtggtcatc tgggcctgga atgttctttg tatgagtaca atttctttag 107580 taaatataag actatactaa ttatttgttt ctttttgagt gtactttggt ggtttttgtc 107640 tttcaggaaa tttgttcatt tcatctaagt tgtcaaagat attggcaaaa ggtgttcatt 107700 ctactttctg attattcttt tagtgttttt aaaatctgtg gtaatgtcac tacaccattc 107760 tcttccttct gattttgata agttctgtct tctctcttcc tttcctaatc aatctgacca 107820 aaactttaac agttttaaaa taagcttaat gatattctta aataactaac catcatttgg 107880 tttcctttca acaatttgta taaatttaag gggtacaagc gcaattttgt tatatgcgca 107940 cattacctcc taatgaagta ttgactttca gtgtatccat cacctgaata atgtacatcg 108000 tactcattaa gaagtttctc aacgccttcc ccactttcac ctcaccccta cttccaaatc 108060 tccagtgtct atcattcaca ctctgttgtt tttctgtttt gtatttcatt gctttttgtt 108120 ttgatattta ctatttttaa aacttacttt gggtttaatt ggctcttctt tttctggttt 108180 cttgtggtgt acactgagga cattgttctg agaccattct tcctttctaa tactgagact 108240 gagactcaat gctctaaatt tttccctgag cactgtttat cagaatccca taacttttga 108300 catttcattt ttattcagtt caaactactt tctattttcc atgttgatgt tttaaagctt 108360 tgttatttat ttaatttgaa gctatttgga gattttccag tgacttctat ttttcattcc 108420 aatttagtta ttttcagaca aaaaattttt tcacaatttg aatctttaag tttattgaga 108480 attgttttat ggaaaaacat atggcctaac ttgaaaaatg ttccatgtac acatgaaaat 108540 aatgtgtatt ctgctgtcgt tgggtagagt gttccaccca ttttaatttt gttaagttgg 108600 ttgatggttt tcatatcttt aatagccttt ttaattctgg ctacttattc tatcagttac 108660 tgaaagaggt gtattaaaat ttcctacaat aattatctgt ttctccatac aattctatta 108720 ggttttgcct catatatttt gttattaggt acgtaaatgt cgtaaactag catggtgtct 108780 taatgtattc agtctttcat ctttataaag tgacttttac ctctttgctc taaaatctcc 108840 tttttctgat gttaatattg ccactccagt tcttttctct tggtctagtg ttatcattac 108900 atatctatat ttttaaacta ttctttacct tttgtattta tatgtgtatt tgtaactaaa 108960 gtggattttt tttttttttt ggtggggagc tgtatttatt tcccagggct gtcagaacaa 109020 atatccataa attgggtgga ttagaacaac aaaaatttat tctctctaga gaagaacgtt 109080 ttcttgccac tccctggctg ctggtcattg ctggcagtcc ttgtccttcc ctgactagta 109140 gctacatcat tctcatttct gcctctgtct tcatatggct gtcatttcac tgtgtgcttg 109200 tctctgggtc ttcaagtggc ctttttataa ggacactggt cattggatgt agggcctacc 109260 ccaatccaat gtaacttcat cttaaataat cacatctgca aagaccctgt ttccaaataa 109320 ggccacattc acatgtactg gagttaagga catcaacata tcttttggtg ggggcagaag 109380 gggcaattca acccataata gtctgcctct aggctctcaa aatttatatc cttcctatgt 109440 gcaaaactca tccacccccg tcctaaccta cacaaaatct tagccctttt cagtatcaac 109500 tctaagttca aaacctcata taatgtcatc agtttttaaa agctccactt ctcattttct 109560 aaatcatcta aatcaagtct ggatgagagt ctgggtatgg cctactctgc agtaaaattc 109620 ttcatgtgtg gagctgtgaa attagaggat aaattatatg ctttcaaaat gcaagggtag 109680 taatagccat aggattgaca cttccatttt aaaggagaga aattggaagg aataaaaggg 109740 tcacagaccc caagatattt ggaaataaag cagaataaat cccattagtt ttcaaggcct 109800 gcaaataacc cactgtagct tgtcactctg ccctctgggt ctacagaagc ctaattcagc 109860 ttcagaatct gcaaccctag aggccccatc agcctctttg gtctcaaggc aaacttggag 109920 ttattcttcc cttttcttga agaatcacac atgttcacaa ctcattagct ctatttgcct 109980 ttttgctgcc tgtagatctc agaagtctga gagactctcc ttcatttctt ctcatctctg 110040 ttccatcagt caaagctggc aatgtctttt gtgctatcac attaagtagt gaattcaaca 110100 gttaagccat ctggtcctgg actttcctta gttgggagat tttatattac taattcaatg 110160 tttttggttg ttataagttt gttgagagtc tctacttgag tcagtttagt tatttacatg 110220 tttctaggaa tttttttatt tcatctggtt gtctaatttg ttgacatata atttttcata 110280 gtgttttatt gtaatccttt ttcttccagt ggggtaggaa gtaatgtttc tactttcatt 110340 tctgatttta gttatttgtg tctcctctct ttttatcttt tttgtaagtc cagctagaga 110400 tttgtcaatt ttcttgttcc tttcaaagac caatttttga tctcgttgat taaaaaaaaa 110460 ttataagcaa caaaacaaat aaaaacaaaa taaaatgaaa gccagagtga tagtgagagt 110520 gagggcaagg tgggtggggg tacagggaaa ataaccactt ctcctggtct ttgcagattg 110580 gttctgtgtc aggaccctcc tcaacactta gacaggtttg cactggctag acaacagccc 110640 acgatgaaaa ctcaaggtct tctgaggcct ttgctgagca tgtgtctttt gggtacacat 110700 gtagctttct gaatttctca gcatacttgt ctccttttgt taatttctaa agaaacgctc 110760 cctagctttc agttttgact ttaggtagtc tattgtatgc tttgacagtc agcttttgtc 110820 ataagcatct gagggtcctt actttggctt gcaatgttcc tggcaatact agctgccttt 110880 ccagcctgag tttccagttt ggcaaaacag agataaagaa cttatgtcac tcctacaggt 110940 agccctacac agggcagaac tgataaacac aatattttct aataagatct tattcttttc 111000 actccagacc aatgggaaag ggtcccacac tgggaatgca agctatagac acttgaagac 111060 caagactgtt caaagagggt aaggtggcag gtcgggagga agggagagta caaaggtttc 111120 ctagcatttt aaagtaccat tttcttgatt ctgtattttt ttgattacta taatgtttta 111180 ctgtattcct gaattctgac aaagttggtt ctgacaattt ctgcttgttt ccaatgtttc 111240 tgttgggaga cgaaaggttg gagcttcctc atccatcatt tcgcacatgt ctaggtcaga 111300 agtttcctga ttactgtctc ttcaagtatt tcctctgcct catcctgtcc ctgccaccct 111360 ctgaagctct cattacactt ctgttagaca tttcatgttt tatctcagat atctgatgtt 111420 ctgtttattt cattcttttt tgtctttgta tttcattttc aacagttttt atagatgtgt 111480 tctcaagttc attgaacttt cctctgcttt gtagagtcag ttgttaagag cagctaataa 111540 attcttcatt tataatattt tccacttcta atattttcat ctgtcctttt tatttctatc 111600 tctctgctga agtttgcaat ttcttcaccc atgttgtcta cacatccact agatccttca 111660 gcattttaat tacagtattt cattatcctg atttttaaca ggatgtgttc cctctacaat 111720 tattctttgt atttaatgac tgaagttggt tttcctgatt gtgacctctg gtgttttaag 111780 gactttggtt ttaatttgtt gtccaactct tggcttcaat ttgctctcca gggctgacag 111840 gtgttcccaa gctctggcct gggactcatg cttagtcagt gagattcttt ttatacagca 111900 tgtaatggag cacagcaaac cttctctgat ctatatcccc atccctctct ccgacaccct 111960 tttgagactg gtataggccc cttcatgtag taggacactt agttatgatg tcgctacatt 112020 gaaacacagt gaataatagt ataagcctta gaatagatgc acctgcactt aaatcccatc 112080 ttcatccttt ataagctctt tgatttgggg aaaactcact tcactttttc aagccttggt 112140 tccttaaatt gtaggttaga cagaaaataa tacaccttgt agaatcattg taaagattaa 112200 ataaagaaca ggggaacaca gtgcctgaca ttcattaagc agtcactaaa ctgtaattgt 112260 tattatttgc tttatgactc taacctcact gagctttaat ttctttatct gaaaaatgat 112320 ggttatgttg tataatagta acacagtatc atgtgccttt ccctataaaa taacatgata 112380 attttaatga ctaaaattca gaacacaatt tacaaattaa aaagtgttct tacacagatc 112440 acatttcccc agaaactcaa aaggcaggtg ttgtgttccc ttcctgtaga tgaggaagct 112500 gattctagga gactgctacc agggtgggtc ataagccagt gtctgtgtct ctttaatcct 112560 ggttctgtgc tttttacatt gcatgagtct aaactctgca gggggaactc aaccgttcct 112620 attctttagg ccaatataca catatggtct catgatttcc tttcatttcc cttaatgcat 112680 tctaaacgct gctgatttgc tgttttatgg acttcttggc tgtgtttctg agtatttttc 112740 catgctgcat ttcatttcat catcttctgt ctctatttcc aaatgtagct atttgttcag 112800 cctggttttg ctctgtgagg tgttatttac aatacttact aatttaatct ttgttcgggg 112860 aaatccaagg agcaattgca tacttctgtg aatcattgat aattcaagcc tggaaaaatt 112920 cacctagcac taggatcctg ctcttttttt gttcagtgcc atatgtatat atagtgccat 112980 acgcatacat atgtacagcc ttattccatt ctatactgta attgatgtta ttttgattgt 113040 tttgtagccc tttgaagcag atcccattgc ctacaaaatg aaaatgggta aatatcattc 113100 acaaaatggt gattgattgc aagcacggtt taccatacat ctaatatgaa cagtaatgta 113160 ttccctaatc acaaattctg gatacaaact cagaagccaa aaatgtgtga cacttaaaac 113220 ttgagaaagc caaaactaaa agggaattca cccagccatt ttcctgttcc cagcagatga 113280 aacatacaca gcaacctgca gtaagtcaca tatgatgcac ggcacatgtg ggcagtcaga 113340 gcctaccacc acactgcctg tccccagacc tttctggaaa gcatccttgt attaactctg 113400 gatttcattc tagcattatt tatctgactg tttcttcatg tacatggagt tggaggcttt 113460 gttaaaaaat ccacttaaaa tactaatttt aactactttc ccggtgtgta atgcatttct 113520 aggatgcatt acttaatgca gtacatcaat tagattatag aatttaacac cggattcaaa 113580 tatatattta tttggttaga atagcaagca attataggaa gaactcagcc tgaagaagga 113640 gttttagttt cccatttctg tggttggcta ctactaataa tattatagtt gctatgattt 113700 tagagtttga ctaaatatca ggcactctgc tatataaata cttgcttttt tttttttttt 113760 gagacaggac tttgctccat tactcaagtt agtgtgcagt agcgtgatct caactcactg 113820 caaccttcac ctcctgggct caagtggtcc tcctgcctca gcctcctgag tagctggaac 113880 tacaggcatg tgccatcatg cctggctgat ttttgtattt ttgatagaga tggggtttcg 113940 ctatgtcacc caggctggtg ttgaactcct agactcaagg gatcctccct cttcagcctc 114000 ccgaagtact gggattacaa gcttgagcca ctgctcccgg ccaatacctg cttttcttta 114060 atgggtgctg gtgaggttaa aatgaaatta tttctgtaca aggcaactga atggctcttg 114120 agtaatcata aagaacattg tcatggttta gatgcgtgtc tccccaagcc tcatgttgaa 114180 atgtgatccc caatgttgga ggtgggatct actgggaagc attaagttca caggggcggg 114240 tcctttatga agggcttggt gccatcctca caataatgag tgagttctca ctctattagt 114300 tcccatgaga gctgattgtt aaaaatatcc tggcatctcc tggtcacaca caggttcccc 114360 ttcaccttcc aacatgagtg gaagcctgag gctttcacct gacacccaat cttccagcca 114420 gcagaactgt gagccaaata aacatttttc cataaattac ccaacctcag gtattcattt 114480 atagcaaaag aaagagatga aaacagacat taaatgttat atatattttt taaatttttg 114540 tttaagattt tttttttacc agtaactgac aagctaattt agtatacact gttcacttaa 114600 tatgtttttc agtcttcata acttagatct tgttggattt tcggcctcaa atattcttac 114660 tcttttccat caagatgtct gtaaatctat ttaatccttc aaagtataat ccaaatcctt 114720 ctatccttga agattttcag atttttccaa acaaggtaat ttctttttcc tctgaatatt 114780 catagctttt aaatctctgc catagcaatt gttttctact ttaaattgcc actggctgcg 114840 tgcctctctt atttgctctt gtgaactatg agcccctcaa agccagaact tatgctatat 114900 aaatattttt tctctctctc tgaattaaaa aaacagtacc atatgactct cagtaaatag 114960 ttgataggca ttgctgaatg attttcaatt ttatctaata tcggcaaggg ttgcaggact 115020 gcaaaatatt ttttcactac tggttttgag aaaaggtaca acggatgaag tgttcaatgg 115080 cacttcctca aaaacctgtt gaagttctat catttggcag ttggctagga atcatacagg 115140 gcatttatct ttgaaatcag tgttctcttt gtcttgaaaa gggtaggcct gtcatgctgg 115200 ctcacgcctc taatccccgc actttgggag gccaaggggg gcaaatcacg aggtcaggag 115260 attgagacca gcctggccaa catggtgaaa ccctgtctct actaaaaata caaaagttag 115320 ctgggcatag aggcacacac ctgtagtccc agctacttgg gaggctgagg caggggaatc 115380 gcttgaacta ggagacggag cttgcagtga gccgagatcg cacccctgca ctccagcctg 115440 ccatctcaaa aaaaaaaaag ggggtcacat taggaatttt tttttttttt gtaatgctta 115500 tgtataagaa accagcttgg aactgagagg gaagtgtttt attagtcatg caaattgagt 115560 ttattagcaa gatggtgccc ctgtagagtc aggtaaattt agtgtgtgtt tgtttatgtg 115620 tgtttggtat ggcttttgtg tttttctcta catttggatt tatagtgcag tctctaaaaa 115680 gtattgcttc ttttgggaaa tgtgtctctg aaactgcctt tgaagaatta taggtaatga 115740 gataaatcta atatgaatga ctccaccttg cttctaacct cacagactat ttttattttc 115800 ttaatctagc atggaggcca agataactat gagagaaatt tagttttagt taaactttga 115860 ggctagggaa attgcccctc ctccttgctg gaagattgaa gccagattca tagggcaatg 115920 ttagaattat ggcacaggtt gtacttttct aaagaatagg cattgttaaa ccataacctg 115980 ccatggctta gcttgttttc ctgtaagttg tttgctgccc caaagtcatg taactgggct 116040 tgggtaggtg gggggtgtta cttcccacct acatcatcac catagacaac atcaccactg 116100 agatattttt cagatttagc atttcagcag accaagagct gccaccaagt tctgagactc 116160 cctcccaaaa actgactcag ctgcatgaag gctgttttag acacctctgt gatttcatca 116220 gttgtttcag tttcccagcc ccctgcttgc caaagtaccc taaaaaaccc acaccttcaa 116280 attctcatgg aagggtgggt ttaagaagtt tctccctgtt ctcttcactt ggctggcatt 116340 gtgatattaa actcatttct ttgctgtaat acctgttctt ctcagtacat ttgactttct 116400 cggcagcagg ctagatgaac ctgttgcact attaccactc ctctatccaa aatccaccag 116460 ggcagttatg ggtcagaact ttagaagatg acagaaggcg aaggtcatct ttactttgga 116520 tcccagagga caacaactaa ccagttagca gtgccattgc cacgctggtt tgttctatac 116580 taacccataa ggaatgcttt tcagtgaaaa acctaggctc taagaaaaca gtgatcaaat 116640 actttgtttg cctccactag gtcagagagt aaggtgaggc acacttgggg cctggggtga 116700 gagattggct atcgccagct gtgcattata gagaagcact ttgcctgcag aaggaaggga 116760 ggcttctgtg ttgaggaaag tgctatcaag aaaattaact tagagtgttt tctgagaata 116820 agcaagaggg aaagccaaat catttatagg ggaaaatatg gaaaaagttg aggggattta 116880 gaaattttct agggatggat aatccctctt ccaaatgtga aaatggcctt tggcaactta 116940 gaaaagcaac agaatagaat gatttttcaa ttcagagtca aggattgtgg ctaaggttct 117000 ctctcttggt tttgggagga tgatgtctgc aggacagagg gaaaaagtca gaaagcggac 117060 ataccagaac tgtgtggctt caagcttatg ggtagaacca ttgctgccag tgcatctagg 117120 tatctgcttt ttcaactgtg accatatatt ttggtgttat aattattttc ttaagaaact 117180 atacgttttt attggggctt actatgaccc cagtatttta tctaggtagg ttataacatt 117240 aaatatagta ttaggctcac tttattttat tttttattat tttttaaatt tggggggtat 117300 ataatagctg ttaaaatttg ttttaagtag tgttcctcaa cagagcctaa aacgcaagac 117360 aaagtaagtg aaatcttaaa tctaattgct tcagatatgt aaacatttta tagaaaataa 117420 aaacaacaat aaaacaaata aacaacatca ctaccacccc caacaaaaca accaaaccag 117480 ccaaaaggat caagatcttg taagataaat ggacagtttt ttatattcat acctagagtg 117540 tctgtgatat ttagtattaa tattattatc ttccattcag cttcgtttaa atatctttca 117600 acatagtcta atatttcaat aaatgaatta tttttctggg aaaataccat gaaacattgc 117660 attctgaggc tcatccaatt acattctgag caagtatcat cttacggaaa agaaacaagt 117720 tctattatgc cattgagttg agcacttcat atccattttt taattcagtc tccttaacaa 117780 ccctgcaagg ttgttgttgt tagcttcatt ttatagttgg ggcaagtgaa gcttgatgac 117840 atttggtaac ttgtgcgaag agaactagag ttcataaatg gccaaactta ttctaaagcc 117900 aagtctatag gcttccacag tgcatttcct gaaccgccat gctagacacc ccctgggtaa 117960 gagcgcttct aactccaaac ttctgtgatc tggagaagtt tggaaaagca acagaataga 118020 atgattattc aattcagaga caaggattgt ggctctcttg gttttggaag gatgatgtct 118080 acaggacaga ggaaaaaagt cagagaaaaa agtcctgata atgagaattg acaaagcact 118140 aaaagatttt tcacctttaa ccaaattttg ttctatgtcc ctggatcttt ctttaattaa 118200 ttatgaaact tttgattgct taagtatcat gtatagtttt gactttattt gagaaatgtg 118260 cattttgggt aaactcatct tgagtataat gattgttatg tttactagat ctaagaaatt 118320 aaaatatcta agtctttgta cactaaagaa gtacaggatt atttttaaga aagcaactca 118380 tatgtttggg aacatctgta tacatcatta atattttctt ttgtttgtag atattcatta 118440 ttatgtagac accactctgc tttaaatctt tgaagatcaa ttttgagaaa tttgatagtg 118500 tttggaacaa acagtattct gctcaactgg catgagtcaa aggtccacat tacccttagg 118560 aaaaaaaaaa aaattattgc tttctgtgag gggttttaaa gatgtgacat ttttcaatat 118620 ctgctttata acttttgatg ataaaaacaa aataataaaa aattacagca gaaaacattc 118680 tttgaaggct tataatgtgt caagttctat taaaaatgtt ttatatgcat atttaaattc 118740 atcctcatag catccccaag agatagaggc tattagaacc attttacagt tgggccaaat 118800 tcagtcagct cagaagtgac agttctggga attttcttct ccagagccca agattttaaa 118860 cattgagcat atttccttct aaagcatatt gccaaatact atagaaggac cgtgaattat 118920 accttgtgat tcaggctacc atcttgaaac taaattatga gtgaaaacat tttgtttggt 118980 tacatttttt atatttaaaa tacatttgaa aagaatttgg aatgtgttaa agtcagagtc 119040 atatattgag acctcgtatc tgaattgaat tactttaaac aaagtggaaa gaactttttc 119100 catcaatttg aaaagtaaag taaaagacag aaagaaacag agagattaaa tgtttttccc 119160 ttattttgta tattgtgggc agtgccattt atcttagcta tgttaataaa cactggattt 119220 tcagaaggtt tatgcttcat ccttgcttta tgctgtaatg tagccacaca gaatgtctct 119280 ttatgttgac tgaagttaat atatgcatct taccttttaa tattgcatca actatagtca 119340 tagtggtgga aaataataat gctctgtgtt ctgcactatg gtggatgttt tataaacagt 119400 atctgcaatt attacaaact cctattagag agctatgtct aaccttattt tacatgtaag 119460 acatagaaat tcgaagttcc cagaatcagt gagtagtaga tttgaactga gttttaacac 119520 aactctaaag cccaagcctg gcctccttcc gctgcgcaat tctcctccag agggaaaggc 119580 tagcaccatc cctaagaggg gccgaaagtc ttctaagggc acctgaacca ttgtgaagaa 119640 ttgtgttaat aacccagtaa ttcacacttg ttcaaatttt cagacatttc ctgggatgca 119700 gtcaaaactt ttaggagtct gaagcctgag gctgcctgct ctctgctgct gattatagag 119760 ctctctagtt gatgagtggt gtcctggagc tccctggcca tacatacaca gtgctcatgg 119820 gtcgactgta tggcaccagc ctctgctgct ctaccctttt cagccttttt ttctggaatg 119880 catgctgagg tcctccttgt gcctttgaaa tttttatgaa gagggtgatt atttttggta 119940 cagcaaaata tgtagaattt gcacttctta ggaattaaac atctcaattt ttttccccca 120000 gagaaaataa ctcttgagca agggaacact catctcaccg ctcagacttt gaggtggccc 120060 tacatgtata caagtttggg ggaacatgag aattccaatt aaattctggg aaatccagac 120120 atatattcaa caagtattta ttatgtgcca ggcgttattt tgagtgctag aaatataatg 120180 gcaaataaaa cgaaaagaac cctgatcctg atggagtgtg cgtctaatga gaaaaatata 120240 caataaggac ataagcaaat aaattcataa tatagcatca gaggcgataa acagtagaag 120300 gaaaagtacg tcagtgtaag gcacagagag ctcccggggg cagagtgttt tcattaggtg 120360 gtcagagaat atcttgtttt tttgtgagca gcttcagcca aagtaagtaa tcaagaatta 120420 tacttgaaac gattggtttc cagatgttaa gtataacaaa tattaaaatt cctcggtcta 120480 acaccctact catcttccag ctgctttaat tagagtagtt tctatttgtt ctacaaatag 120540 ggcttccttg taaaattttc tttggagatg ggtttcatat ctgagagcac tgcctcagac 120600 caaataaata ttaacacagg aggaagctga gcgtcaaagg gaagcagtaa cttggccaag 120660 gatgccagtg ctcccagtgg ccaagggaaa cccaggctgc ggtcctctct gtccaagctc 120720 tgtcctcggc cctcaggtcc tggcctccag cactgagagc aacacagagt gcctgtgagg 120780 cggtctaact tctgctgact ggtgaaggtg gatcccccag ccccaggaaa agtcaaccag 120840 cagcttgaac agcgcttccc tcgcggaggc tcagcactca gctcatcccc cgccatcggg 120900 ctgtaattca ggtgccagcg ttgctcctcc agcaggaaca taagcccaaa cttaacaaat 120960 tcctaaagca gaacaaagaa agtgtcagag gggaatgggc acggagcctg tggaccgcac 121020 tagaatcttc taattcttag gaatgcagat cgccctgtgt aaggggccgc tcagagcgcc 121080 cgaggagcgc cggtggcctc ccttggatgc ttcgctattc atcccacctt ctggaagagg 121140 ctattctttt gtggctgtct tggtgtttgg ctgagttgtt attgaattcc tccctgactt 121200 cttttttttt tccttcggaa gacagaagaa aagaagccgg cagtggaagt cttctctggg 121260 aagcctcctc ctcctgcatc tggctgctcc ctttggggca gcctggtccg cctctctggg 121320 cgccaggtgc gtctgcagcg ctctcctgga ggccggctgc aggttcatta gtgctcacaa 121380 taggcacgca gcgcagggga atatgtaaag aaagtggagg acatcggagt ggcattcaaa 121440 gcggcaggcg ggagtaggag tttccctagc ttttcttcct ttgtttctaa tcaccttttc 121500 tgtttcttca gagaggatgc taatagagtg aatacctggg cgttccagga gaagagttag 121560 tggaggtttc agaaaaggaa atgcaatctg ggacgaaaaa tagcttttct tccccttggg 121620 gtgtgtgtgt gtagtgtctg aatgctttgc caccgatgag gccgaggact aaaagcagga 121680 taaaggctgt gattggcaca gaagacccct ggtgaaattt ctggctcagg tactagcttt 121740 ctgtgagtcc tgtgcaattc ggcacagccc ttggggcttt gagtcctttt tttttttttt 121800 tttttaataa aataagagac ttggctaata ggatttctag cctaccactc ctttacagtt 121860 ttaagatatc attttaaaaa gttacatttc aagactgtag taaggaggtg acattatata 121920 cttaaacata aaaatgtgga gtgatttgaa gagcactgaa attattccac tcttcaaagt 121980 atatgcattt atgtatacat acatgtacat acacgtgtac ataaacaaac atatacatat 122040 agtcattttc agatgcctga aattctgtcc ttaaagacag ttgtgaatcc cagttctatt 122100 agtatttgac tgtgaccctc ttagttttgc ctactgtctg caagactcaa tttttctttt 122160 tttcctcata atgggaataa atattgtctg tcttctaact gtgttatgat atttaaatga 122220 ggaaatgtgt tgaatggtag ttcttcttgt ctgaaagata agaatacatg ggtgccatca 122280 tccaatctca aagtcattgg gttttgacag aaatggtatg atgggtaatt atcccatttc 122340 tccaaagtca ttaggaacct gaagtaattt ttttaaactt gtttttcatg cacctgtgtt 122400 ggctagatca cagagcctgg gcccatcctc ttgaggaaat attatctgcg tcaaccttcc 122460 tcaatgcctc ctggatgact ttaccaccat cttgcaaatg tctattattt gttagctcta 122520 gaagactcag agcaatgatt gcaccaatct gaaggttatt tcttccatgc tggtcttctg 122580 ccattggtga tattacagat gtttgtccag aacattactg atgacagcta cacacctgga 122640 aaataaagtt tcttgtttgt tccttccaaa ttaattttct gaatgaacac cagcaactca 122700 aaatgcattc agtttcagaa ttcaaagaac agaagagcaa atttgaggga cactctggca 122760 cagtagaggg tatgtacaat cattgaatgc aaagtctttt acattttacc ttacacgtca 122820 atctcagcta atcaggcttt atttttcagg aaagtgctgc agagcagaga agcaattctc 122880 aacaagacaa agctactata atagcgactt gtggagtcac gttaagaaga aaataggcag 122940 agaagtggac tcttgacggg agtctcatcc atcatttcct ctctgtgcaa cctcaggcag 123000 ggtacataat cgatctaact tttagttttc tcttatgtaa tctggagata ataacatata 123060 ttttatataa ttattgtgag tattaaatac caaaacccct ttatgtcaca tgtttagcat 123120 agtgtctata tcacagtatg tgcgtcatat gaaactcagt gctttgtacc cgctgattcc 123180 tggtgaatga aatacggtca cacatcacaa tgactgtctg ctgaaatgcc aaaatcctgc 123240 ctgtagttca ggaaccagag taaaggaaaa tgaaccctgt agtgttttta ctttttctct 123300 ctttttagag aaagatcatt tgcatgtggc tccaccttaa taattgcatt tgtaatgctt 123360 tcatgttgtc acatggtcta acccccagga tcttatctta ataaaaattc agttaaacat 123420 gtgttcaaat tggccagatc agccaaatct ggaacaggga aagttgtttt cctcctaatg 123480 aactgtcccc tggacacggg cagtgccaca gaagttcagg aatatttatt gtccatggca 123540 tttccaggag ttacactctt tgttgaaccc ttccatcgtg ccagggggag gctggtgatt 123600 cattaattca ctgtgatgat ttgtcctaat tattctaatt actgccttgt ctcctcagac 123660 cagctggtgc ctaaagcaga gggaaagtca ccagtcatga ggactgcggt ggtggctgca 123720 gaatcccggg cactggatct gtaggattca ctgtcaccac atcaaaaaag ctttgctgct 123780 gctgctgctg ctgctgctgc tgctgctgtt gctgctgctg ctgctgttgc tgctgctgct 123840 gctgctgctg ctgagcccaa cttatccttg gtgctgctct ggcctgagtc cgggttcccg 123900 gggccctgcc atgcatgcat tctctcctct gctcctcttg taccttttca gggagagaag 123960 agccctgata caggttgctt ttctgtcttc ccagcttgct gccccaccaa ttccagacag 124020 catctgctgt gtgttctttg tgcacccatc cctgtctgaa cgtatcttaa acccagtctg 124080 gtttctaaca actgtcgata ataaaaatat ctatttctta ctgcacacta tcaagtgcca 124140 agatggatgt tcattgccat atgtgcactg tctctaagtg ctacagtttg cagtcttagt 124200 tcatatatta aggctctgca tgacctagag actagtttac attgcccagc aagggagtaa 124260 cacatggaac tgaatcccag attgctgcat ccccaaagtc ggggggccct ttatgcgtct 124320 ctcttttccc ctcccacaag ccttcctggt catctacagg actcctgctg aaaccttcct 124380 tcggtctttt atccctgagc tcctttgctg tgataacata gactgttctg tctggcagcc 124440 ctgggcagtc atcagtgttg gctttgcagg tcagcttggg gtccccaacc aggattcctg 124500 aggccacaga atcttgctgc aaacacagct agtcttggag aactcatatc tgtgcctttc 124560 tgatgtgctg tatcacccca gcctgccctg tgtttctttg ggatattttc acagctcata 124620 cttcagtggt atttgcctct taagtcactt accccttatt actctgaaca aaactggaat 124680 ccgaaaaaaa caaaaacaaa aacaaacaaa caaaaaacac tggaactgtg gctcatctct 124740 cagggaatga gctgacactt agtagaatct atgacatgag ggctatgtta gagaccctga 124800 aatgaagctg ggtgaaaaat atcaaggtgt tgtgagtgac aaagatgata ttccaaagat 124860 tcaactgaga aagagtcagt gtatcttatt attaaaattg cttctgtaag agtcatcata 124920 agcttgactt gtatttcttg accaactctt atttctattc atatctcagc ttaactgtca 124980 tttcttcaaa gaggcagaca tcccaactct acaaactgta ggccaccagc ttctgtcatt 125040 ttataagaac aggtgaatca cttcacactt gaacttattt acttattttc tttttctttt 125100 ttttcttttc tttttttttt ttttttgaga cagggtctgg gtctgtcacc caggctaaag 125160 tgcaatggca tgatcaggcc tcactgcagc ctcgatctct ccggctcaag ttatcttccc 125220 acctcagtcc cccaagtagc tgggattgag ggcatgtgac aacatgcctg gcttatttat 125280 ttatttatgg aggcaagatc ttgctatatt gccagggcta gtctggaatt cctgagctta 125340 agtggtcctc ctgcctcagc ttcccaaaat gctgggatta caggagtgaa ctactgtgcc 125400 tggccttgaa cttattttct taatgcttgc tttcccaagt aggctgaaag ctttgggagg 125460 ctaagaggca acattttgta attacctgat attcttagtg ccaagagaag gctggctctg 125520 ggcaggccgt ctgcccatgt gctcgacaag gcctgtattt atgtatctgc aggcaggccc 125580 ctcatttgta ggcgactagg tcttcttagg gattcctggc catactagga ggtcatctgc 125640 agggacgcct gcactgatgg ggagtccttg agagccagct gactacagct ctgggatgat 125700 gagggtggga aaattgtcca gttagaagaa atactgaaaa cctcaatgga caaactggaa 125760 cttcaggaag aatggtggtg gacagaaaaa aggaaaaaaa aaagagaaga gtgaatgaac 125820 caaagtgaat gagcctcatt tctagatcta cagacttttg ataacacctg gcctgtttat 125880 atcacaaagc tgctaggctt tacaaaacaa attcaaaaca aaaacaacaa aaagccatga 125940 agagctatct acgtgcaaga ggttttatat ttagttgtgc tttattttac taaccaaact 126000 gaagactagc ttgctgggtt ccatttcaca ctgccagctc ttcactgtgt gcattcatga 126060 gcctgatgct aatgagacct agagtgatct cataggcaac ttgcaacgtt caggctggac 126120 aggtaagtgt gatgtgttgt gttcaaaagg aacagatggt ttaaatttaa attcaaattt 126180 tgaaggaaac acaaagacaa agtgaaactc tttgaatgtt agataaaaat gttgatattt 126240 attaatgatg atatcagatt taatggaatt tggttgaact attaaactgt ccactaagta 126300 gaaattaatg ccagttcttt gatcttttta tataattaca gtaataattt agacttttct 126360 tgactgcaac tctggggaga tgtaatgata gaaaaaacaa accaaacttc agggcatatt 126420 cagcatgatg tctgataaat taatgctctt gatcgtaatt tgaaaaggag ctcttgccct 126480 gcaggaagct gaccgggaaa cagaagcttt attagtgcag agatggcatt gactacacct 126540 acggtttatc tccactctgc tctgaagcag caaaagtagt gagacacgga ctgaaacagg 126600 atgttagttt tctgaaggag cagatacatt taagcccagc ttcatgcagt ggaaagggca 126660 caggactggg gctaaggaaa tgtgtgttct acttagagtg accaaggaat cagtcaaatt 126720 cttttttgag agttaagggg aatcatttaa taattatgtt gaggtaatac gtgtgaacta 126780 gaacgatcct tggcaaatca ggaccctaat ttggctcaag actagtcact taataattct 126840 ctcatctcat gtgattctct tagctttctc ggatctcagt ttccttattt gttgcaattc 126900 ttgcctgtaa acccttaaga gtgctaagag aataaggtaa gagaacatat gataatgaaa 126960 ggttggaaat aggaaggtga aaatagtcat ttggtagcat tgttctgatg aagagggtaa 127020 agctaattct cccataaatt atttgtgttt cccctgttga ccagaagaat gaagaataac 127080 tgagacaaaa attctattta tttcatagca tgatgtggcc acacattcta aatgttaaag 127140 ccttagtttt gggttaggag cttacatttt agcaccaagt ttccctgtta ttatttttcc 127200 tataggactg tcaagattta ggcaatatgg ccgctttaaa acataaaaat taactttact 127260 catcaaaagc acagatgact accaatctca agcttttagt ccaaatgaaa attcagtgta 127320 aataccttta gtacacagaa ttccagctga atgggaaaaa aaactgatta actcatattg 127380 tattatttgg tgagaaatta ttctttcttt ggggctattg ctgagtacta agaaaagaaa 127440 atgaatatcc aggatctgct gctactcccc aaaaaatata ttattgtctt ctttcttctt 127500 gaattttcta agggccccag tgagggctgg gcccttccac atgccgtggt agctaagctt 127560 cagagccagt tgccagggat cggaggctca gcaaggctca ggagagtatc caaggtcaaa 127620 cagctaacaa ggaaaggagc aaagactgaa gcaggtgaca aatcctctat gctctcctct 127680 aatccagtca ctaaccctac ctttggtagg aatctggaaa taagaggaga gattaagtac 127740 ttttcaaatg ggtacaaaag ggaagttttc tgggatttta ggatggtgtg catatatgct 127800 gaagtgtgct tgaaaacaaa ataaaatgca ggtgtggaag aatttttaaa aaccattgta 127860 accaaggggt tgattgacta atataatgtt agcaataata cttgccatct gcaattttgc 127920 cattctcata agaattggtt tagcttaaaa acattgaata gctaagcatg tgtttaaaaa 127980 actctacttt aaaataaaat agatttaata tgttatttga cttcagacag gtcttatgtg 128040 atgatttgat atagatcatc aatactgaaa tgaacctatg tttcatttga gaatatctgg 128100 aaaagagaag tgtgaatgtc agatttcaaa tcaaattatt tctattttaa aatataatca 128160 tcacaatact tttaaagctc aatgagctta ttttatccta catatgcaaa ccagagtaag 128220 gttaagtatg caacttcatc ttgccaacag ctgtaagggt gaccatcacc tgggaactcc 128280 caaaaaccct aaaagcacct ggctgggctc gcttgcctga agcaaagatg cccagtggga 128340 ggatctcgct ccatgaagag gcactgagag ggccagtgat gctagcagac agagaaaaag 128400 gcattctgct gcaggaaaag ggcactagcc aaaccgggtg tcccacagat cactagcaca 128460 ctatcaagtt ggtgggactg taaactagtt cactagttca accattgtgg aagtcagtgc 128520 ggcgattcct cagggatcta gaactagaaa taccatttga cctagccatc ccattactgg 128580 gtatataccc aaaggactat aaatcatgct gctataaaga cacatgcaca catatgttta 128640 ctgcagcttt attcacaata gcaaagactt ggaaccaagc caaatgtcca acaatgatag 128700 actggattaa gaaaatgtgg cacatataca ccatggaata ctatgcagcc ataaaaaatg 128760 atgagttcat gtcctttgta gggacatgga tgaaattgga aatcatcatt ctcagtaaac 128820 tattgcaaga acaaaaaacc aaacaccgca tattctcact cataggtggg aattgaacaa 128880 tgagatcaca tggacacagg aaggggaata tcacactctg gggactgtgg tggggtgggg 128940 ggaggtggga gggatagcat tgggagatat acctaatgct agatgacgag ttagtggggc 129000 agcgcaccag catggcacat gtatacatat gtaacaaacc tgcacattgt gcacatgtac 129060 cctaaaactt aaagtataat aattaaaaaa aaaaaaaaaa aaaaaggaga gcctcgtcaa 129120 caagatggag tgaaggtaga cgggtgcttc agtccctgta agacaaggca gggaccggca 129180 gggctcactg agcacttgca ataagttatg cacagagacc ttccctatat tttttcatat 129240 atgttttact gtaacccgat ttagtagata cccttttata aatgatgagt tcctggaatt 129300 cttggaataa agagcgatta gattgcttgc ccaagatgac agttataagt gatgaagaca 129360 agatttgacc ttctgtagta ggatttctct ttctgaattt ttaaccactc acaaaaataa 129420 gtgctttaaa acctagagga tttgaggatt ctaatagtta ctagaggaaa gagatgaaga 129480 agaggaaata gggcaaattt ttttagtatt atattctagg ccgattaaaa aaatctatta 129540 gtggacttga tcatttgtta caaaatttcc tgactttttt ctaatgaaaa cacagagact 129600 cagaaacatt aaacaagatt tcaacatcac tcagctaaaa caaagatgaa aggaattttg 129660 catctgtgat tgcagtcagt attctctcca ctattatatg ctgtggagat atgactctct 129720 gagaaatagt gaaacagaaa atattggcct catatctctt cttgagtggt actggctggt 129780 gcacccactt tcttccattc tgcatttttg aatattgaaa ggcactgtgt ttcaacattt 129840 ctctaactct gccctcctaa aataaaagcc tttgagtctg ctcctcacct gacggtcaaa 129900 atatatctgt gtcatgccat agtccctcgg acttttacta ggggacttat tgcctaatgt 129960 tacagacaca ttttatatgt gtttagtatg gtttaatata acgtgctcca tcgggggaat 130020 tggttttaaa ttgtgtcttt atgagaggaa atgatttatt tattcaacac tattggttga 130080 ggtgtctctc tggaccaggc actgggtacc ttacatgttg gcatgtctga caccgtggca 130140 tatttagtgt ggcatctagg ggtcatattt tctattttgg tttttttttt ttttttgaga 130200 cagagtctcg ctctgtcacc caggctggag tgcaatggtg agatctcggc tcactgcaac 130260 ctccacctcc caggttcaag cgattctctt gcctcagcct cccaagtggc tgagactaca 130320 ggcacgtgcc accatgtctg gctaattttt tgtattttag tagagatggg gtttcaccgt 130380 gttaaccagg atggtctcaa tgttctgacc tcatgatctg cccgccttgg cctcccaaag 130440 tgctgggatt acaggcgtga gccaccgctc ctggccatat tttccatttt aatattaggg 130500 agtatattag agacatagct gtttctcaca tagaattatc tgtccctact gcataagtta 130560 acataccagt taggtttccc caaagctccc atccttgttt ctcattcctg cttttagaga 130620 tactggggac aggagaagtc tggtcacctc tctaccacca aggagccaaa tgtcaattac 130680 acaagtcctc cgatttatag tttctccatt aatagagtat ggctaagtgt ttatatttct 130740 gatttcttag gtttttcatg aagatcatcc aggattgtag atgaaaaagt actataaata 130800 ctgaaatgta cttatcctat gtaacatcat tattttatgt aataaatcaa ggcctctgtt 130860 atggtttgat tgtggtttgt tcctgccaaa atttatgttg aaacttgatc cccagtgtgg 130920 tagtgttaag aggtggggcc tggtcttggg catgcaaccc tcatgaatag cttaatgccc 130980 tctcaagggg tgagtgcatt gttgctctca tgagaatgat tagttctcct gtgagcaggt 131040 tgctaaaatg agtctgcctt cctaggtttc tctctcttga catatgatct cttttcatac 131100 atccccctac ttttgttttt cccattagtg gaagcagcct gagacccttg ccagatgcag 131160 ctgcccaatc ttagactttt aagtcaccag acttatgagc caaatcaatc tcttttcttt 131220 aaaaattacc cagcctcagg tagtgtgtta tagcaacaca tagactaaga cattctctaa 131280 gccacatccc tgaaaactgt tttagaacct gcatctatat aagggctttt taatatactt 131340 ggtgtcagaa acccaccctt tcctctagaa aatatatgaa gagaatagat accttgtgga 131400 tgacttctct cccacttaaa cttcaaactg atcatagtaa tcaactccct gcccattcct 131460 ctttcttaca tctggatttt cagtaatcaa taataacaat ccagtaatgg tgcagctggt 131520 atggcagaaa aattattgca gcaaaacatt cacaatgagg ctaatgagat catgtgagag 131580 agggaagagg gttgaatcga tgttgaaact aattttattt cattagcact agatgtaaat 131640 tgcagtataa tggaattaat catttaaaat ggattgttca cttagaagtt acaaaaatac 131700 caacattcca tttggtgcta tctttttcct ctgatgaatc aatttggttt taaaggattt 131760 gtttgtattt aaagtaaagg gaaccaaggg gtttatacag caattcttgg gaacaggaat 131820 gagataagaa aaacagctag agcagaagga catcaacaaa caacaaaaac aacaacaaac 131880 tgagcagatt atgaaagggc aggagataat ttctacctgg agtatgtgaa catggcaaaa 131940 tcaacttaaa aaataagtct tctaaagact taatccattc tgagccaacc tgaaaacagt 132000 gattcttaat ccttcatata catcataatc tcttgggaaa cttttattag atagcaatgc 132060 ctaggcctca tcctaattta attaaatcag aattgttaag agctagtact gcagaacata 132120 tataatgcca acttcctatt tttatttttt atttatttat ttattgagac ggagtcttgc 132180 tctgttgccc aggctggagt gcagtggctc catctcggct cactgcaagc tccggctccc 132240 gggttcacac cattctcctg cctcagcctc ccaagtagct gggactacag gcgcccacca 132300 cccggcctgg ctaatttttt tgtattttta gtagagatgg ggtttcacca tattagccag 132360 gatggtctcg atctcctgac cttgtgatcc gcccacctcg gcttcccaaa gtgctgggat 132420 tacaggcgtg agccattgcg cccagccaac tttttaacaa taaaaatcac gtgggatttg 132480 aacaaaaagt atactaatca aaggaataaa tatttatata tctcctgagc tgcataagga 132540 attatgggat taaagtggta caagattctc ttaaacaggg caattactag cagattaggg 132600 atataaaaat atatgcatta attgtccgtt ggtggtgcaa atgttatata ccagagatat 132660 ttagaagaag gagaaatgac tttggaccca ggagaactag ggaaatctta gagttaatag 132720 gagatgaagc agaatttaaa ggaccatgta tcagcaaact attgctacac agaaactcat 132780 cttagtctta aagactttct aaacaaacat gctttaaaga gtttgcagcc acctcaaagt 132840 tggtctcagc ttgggttgag ttgctaatga tcataaattt ttgtgatgaa caatctattt 132900 cagaaagatg ctcacaaatt tctgtgacaa ttgtgactca aagtcatttc acaaatctta 132960 ctacaaagag atctaaacat tcttttctct ggccaggcac agtagctctt gcataaattc 133020 catcttttgg gaggccgagg cgggcgaatc acttgaggcc aggaattcaa gaccagcctg 133080 gccaatgtgg tgaaaccccc atctctacta aaaatacaaa agttagccgg gcgtggtgac 133140 acgtgcccag ctattgagaa gctgagacat gagaatcgct tgagcctggg aggtgaaggt 133200 tgcagtgagc caaaattgca ccactgcact ccagcctggg taacagaagc taactctgtc 133260 tcaaataaat aaataaataa aaacaatttt ttatcagcag ccttgacgac aggatcatta 133320 atgaaataat tctgaggaac agactcgcta catgcataat tttatagaaa atgaagctga 133380 tttaaagtgt ataaatgatg cagggtgtga tcaatttaag acttgaaccc aacattcatg 133440 gctccaaatg cagtgctcat tttcctgtgc aattacacat ggttttggac aaaggtcttc 133500 gtgttctatt ttattcatac aataatttca atttaattaa cctcaatttt aataagcagt 133560 tattcccaag acagaagcat taagagaacc aacatttttt aagagctcac taggtctcag 133620 acaattacaa gtcattattt aatcttagat gttgtgccct aagtgccttg cttgcttcac 133680 cactgccatg gccctaccag caacaagaac ttatccaagg ttttgtagac atttgtaccc 133740 aaagagggac aaactggaag gcagtacttg atgtatgttt tcatctatca ctgtcaaaaa 133800 cacgcgcctg aaacttccat ttacatacct gtccccacat ctctccttcc cagtccccac 133860 tgtgcttcgt gctcctattt tgatgatatt caatctgtta cgttctctcc accccagtcc 133920 catgatttct tcacttttac ctcattagcg tccagacttt acatgtgtcg tggataaaat 133980 acactttttc taagtctgtt gagaaaatga taaaagtggt atctcaaaca gcccaaggag 134040 acagcccaat gggcgctcga gccctggaca ggcatgttgc aaacaacgtc catcagtaat 134100 caggactgag agagcataaa gcctcagagg tcagaggtca atgggaggtt ccagttgggt 134160 cagaaatgaa aactgcagag aatgcagcag atacatggca ctgttgaaag agaggcctag 134220 aagcagaaga caggtgagtt atatttagct ggggacctgt gggaggttgc aggtgatgct 134280 cagtggagat atatgaatca tcctacctgt tacataggcc agctgggatc aaaggaaaga 134340 ttagagtgtg acaaatggct ttgtatccat aggagtttgg gttgataaga cattaagagg 134400 atttaacttt aatagcctaa actagtttta taaacagtgt ttccagataa gacacagaat 134460 gcccatttaa tgctgaattt gaaattaaca atgaatattt ttaatacaaa tatgccctaa 134520 atatagcatg agacatacta tactaaaaaa aaactgtatc tgaaatttaa atctaattgg 134580 acatgctata atttatttgt taaataccca accctgtgta tagagttgga aatcaccctc 134640 tttactgatt ataggactgg atattcctgt ctaaatgcta atagtgaggg tagagagaaa 134700 gaaaacttgg ccacatactc tgacaatact ggtataattg taaataatgt taaactccgt 134760 ttgctagcaa gaattaaggg agctatgtct gaaatggcac tgttttgtca gtgaattctg 134820 tttacctttt tcttctgtct ggagtgtatt tgtgaagagt cccttattat cagttatgtt 134880 ttatgaaaat cagcacacta ccacaatgac atttaagcac agaatcatta gtccatgttt 134940 ttaataaaca catcgattaa gaaaaaaaaa acttggccac ataaaagtta tttgaacttc 135000 agtttttttc tccgcaaaat gggcataatc taccaacgcc tcccgtagtt gcaaggggat 135060 gtgcatgaga taacgtttaa agtactgaac acaggcctgg aaaggtagca agtattcaat 135120 tgctttcaac cactgctcaa gtcaaccttt tatgaaggcg gggaaggctg agtgaatggg 135180 taaataaatg ttcttggtaa agcagcacac catcagaatt tcactaatat tcatcacaat 135240 ttattttcta cccgaagctc aggatccacc ccattccgta tgggaaacaa tcgaaacaaa 135300 gtggcatagt aagcagtccc atgacagttg tgtggaaatg ccaccctttc tttttaaggt 135360 gaagcagtaa agcttagcaa gtagcatttg tgcctttgac aaatggtagg ctgacaacac 135420 ttggacgtgg ttgacaagta caaaatagca ttcagtaggc aggtgccagg gaggggaaaa 135480 caactcttac gtattgctat ctgtattgag ccagacttta aagaactgga aaactctcta 135540 catgggaatt aagaacatga agatatttca gtaaaatctg ttattatttt taagatacat 135600 tgttttcaaa agctcgtttt ttggccatat gggattgtat tggaaaaata ttcctagaaa 135660 atataattca gcatattttg atggaaatca tttcccttca tttataagta tccaaataat 135720 ccattgtgaa catcagaaat tattgaaatc tctaatgcag ctttaataaa ttccttcctg 135780 tggaatatgg gcgtgttttc tgaagcttta ttgaaaaatg aaagtctcac ataaaatgta 135840 tttcagatca tttaactttt ctatcttatt ttatgatcca gtgaatttta ttcattctag 135900 caagtcgtgc tgaatctaaa cactttagga ttaagattaa aatactgagt atataaatta 135960 gggttaataa aaaaatccaa tatatgtttg gaaatgtagc tactgtcact taaaggaaat 136020 ggtgcagctc ggaagtagag tgtagataaa ttaaccaatt ttttgaaaaa aattgatgtc 136080 cacagaaata agactcagat ggtctcattg ttaaaaatta aggctgatca aagtgactca 136140 actccctagc gaatattttc tctagacact aaatcaagtg cctgtaattg catttctata 136200 gttttattcc atggtgtaat cagggtgaaa aattaagaca agtctctgga caatagaaaa 136260 tatctttcag atagatttca atttcagttg gttggattag ctataggaag cttgtccaac 136320 ccacagcttg tatgtggctc aggacagctt tgaatgtggc ccgatacaaa tttgtaaact 136380 ttctgaaaac attatgagtc tttttgtgtg attttttttc ttagctcatc agctattgtt 136440 agtgttaatc tattttatgt gtggcccaag accattcttc ttccagtgtg gcccagggaa 136500 gcccaaagat tggatgcccc tgagctagag aatataagta caaaagagaa aagctatgaa 136560 atgagtaata agcacctgaa ctttatacct gaactctaat gaaattccac aagtaggggc 136620 cgggcatggt ggctcatgcc tgtaatccta gcactttggg aggccaaggc aggcggatca 136680 cgatgtcagg agttcgagac catcctgacc aacatagtga aaccctgtct ctacccaaat 136740 tagccaggca tgatggcaca tgcttgtagt cccagctact caggaggctg gggtgggaga 136800 atcgcttaaa cctgggaggc ggaagttaca gtgagccaag accacaccat tgcactccag 136860 cctgggtgac agagtgagac tctatctcaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 136920 aaaaagaaat tccacaagta gggtaggtac tgggcaaaag ggaattaaga ctatttgtca 136980 gacttagtac gtgacctgag ttaagacact gtatatatgc aggtacatat ataaacctgt 137040 atgtatcttg ggagatctcc tctgtttgtc ttcactggac aacaaaatca tagagaaaaa 137100 atgcttgtga cacacacaac aacctctccc agccttgcac aaacaggcac accctagaga 137160 aacaacatgg ttagaaaggc agccttgacg tcaaggtgac gaaaggataa gtataagacc 137220 agaggtaaga tcactgcttg agaagttgtt aaaataatct gtcaagaaag aatcaatacc 137280 tggactatga tagtgacaac tcaagtggag agaagtcaag aaagttgaga aaccaaagtc 137340 agtggaataa caggacgcag aagaaagagg gtggaattca agagcagtca gggaccaggt 137400 gtttcatgat gctactcaac aagataaaaa agatataaaa aggaaagggt gatggggaag 137460 acaatgactc agttttgcat aagttcaatg taagatactt gtgggacaca ctaataatca 137520 ctcttagcaa tgcttttgat agttttagac attcagattg tccaaggtca ctgaaacaat 137580 ggaagtcaat gagacaggct ggaggactaa ataaattgga tgcagggtgt gagacacggt 137640 atgcacaaaa gagaacttat ttgtcatttt aagtggatcc actgaagttc tgatgtttac 137700 gatgatgctg aaaaatacac agagcaatag agaagtgtaa gtaccatggc gtgttggagc 137760 caatagataa cttcttggta attttgtaag ctgggtgtta gaaacaacta ttattcgata 137820 ttaaattgta taaatttaga atacataaat ttatattaag cataaagata atacaaactt 137880 acaacttacc atttcttatt ttattttaat ttataattta caactatcta tgtttgtgaa 137940 gctatttaca tctattttgt ctatattgtg gaaaaaccat aatggtgtga tgttgtgtaa 138000 ttctttccag ctctgctttc agtagcatca ccttgacaac ttgaaatcac actaaagtaa 138060 tcagcaagca ctacaaatca gaacttccca tcccagggag ctacctgtga atcatctacc 138120 agcacaagac tagttaagta ggaccatcca tatccaagga aggaatagta gaatacaaat 138180 gtgttccact tactattgct gaattagaaa ttcactccat aatttattag tagcttaaaa 138240 taacaattat ttcataatta aagctcagct tctgtttctg gaaagatgtg actggatagt 138300 cctggattgg ggtgtcatgc agttgtaggg ctagagctgg agggtcaggg ctgatcaagc 138360 atctctctct tcatgtagcc ttctccacac ggtctctctg catgaactat tttggacttt 138420 ttataacaca atggcctcat ggtagttgtc cttcttacat ggtgtcccag ggctccaaag 138480 gcaagtgtct taaagaagaa ggtaaaagct acattacttt tcatttcctt gcctcagaag 138540 tcacagaatc atttccatca cctcttattg gttaaagtca caagcctgcc cagactcaaa 138600 aagagggaaa ggagactcca attctcaaaa acggagtggc aaggtttaag aagaacatat 138660 gggattggag atattttggg gccatctttc aaaatacaat ctgctgcaga tcccaaatca 138720 caaaagaggg agacaactat atgtagctac cagtaggagg gctactctag aggatgcttg 138780 agaattattg ctttcatcaa tctgagacaa aattcacaca catgagctag aatatcattt 138840 ccaaatgata ggttggtagg atttggggga attttatgga gtagagaaaa ccaaacttag 138900 atgataatta acaataaata ttgtctgtat ctttatggct taggaaagtt tcatgtctgt 138960 aaccaggaac tcactacttt ttatttttgt tttgaacatt tcttctcaat tcattccttg 139020 catgagattt tgtccccatt ttgaccatca tacttgtttg cattctcctg cttttgtctt 139080 taatgcttta atttggggat atatatccat atgtctatgg atacatgtat atggatatgt 139140 atgatttggg gatatatatc catatgtata tacatatgta tgtgtataga gatagacaga 139200 tgatagatag atagatagat agatagtaga ttcttctcta cttgcaatgg ggtgatgtcc 139260 tgataaaccc accaaaagct gaaaacatta tcaactgaaa aattatggtt atttagcctt 139320 gtgcccatgg gctaaagaaa aactgtggct catccagaat cataagagct tatcctaacc 139380 tggaaaagat caaaattcga aattcaaagt acagtttcta ctgaatgtgt attgcttgca 139440 ccatcgtgaa aacaataaat cacatggcaa accctcataa gttggagacg ttctgtgtgt 139500 acacgtgcgt gtgtgtagtt tgttcgtttg cttttttttt tttttctgtt ttcctgataa 139560 ctttagtttc tatggacagc atatttagtt ctcacctgct catgctgcct caggttttct 139620 gatgataggg tgaagaagaa aatgcctctg tggcctaagt tctgacccct ctattaagtc 139680 caaaagccca aaaccgtatt tctggacttc caaaagtcca gaaataaaga tacaaagaag 139740 aaattctgag cgggcaaaat gggtactgca ttgttgaata aataaaggga aagttctaag 139800 cagagtttaa attaactaac aatttttttg agacaagacc acattttgga aattttagaa 139860 aattgtttta agaaagaaca tgttatggta tttattttgt attgaaaata gaataacaga 139920 aaagcttaga ggcagaggtt agaatctata gaaaattctt tagggccggg cgcggtggct 139980 cacgtctgta atcccagcac tttgggaggc cgaggcgggc ggatcacgag gtcaggaaat 140040 cgagaccatc ctggctaaca cggtgaaatc ccgtctctgc taaaaatgaa aaaaaattag 140100 ccaggcgtgg tggcgggcac ctgtagtccc agctactcgg gaggctgagg caggagaatg 140160 gcatgaaccc ccgggggacg gagcctgcag taagccgaaa tcgcgccact gcactccagc 140220 ctgggcgaca gcaagactcc gtctcaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaatt 140280 ctttagctgt tctctaaatt tgataaaaat tattgagagt ctgccaggtg ccaggttcca 140340 tgctaggttc ttgagacaga gcgagaagta agatagaaac aagcatctgg taggcactta 140400 aaatatatgt tgaaaattac atgatgcagt agagcctgcc aattagaggc tcatcctcta 140460 attttggaga tgtgacagct ttttatggga attaaaaggc caaagaaagc tgaaggtcag 140520 gtctagacac agtccaaagg tgaaatataa ttaaaaatgc tcgcttgttc aacaatatcc 140580 aggttgcctg tttgctcata gttattagat gattaagtat ctgtaattca gttaagcatt 140640 ctaagctgca gaaaatgcta taaaccagtg ggtttttttt tcattttcat tttctatttt 140700 tgaaatagcg tcttactctg tcaccatggc tatagtgcag tggcgtcatc acggctcact 140760 gcagtcttga actccttaaa ccagtggtgc ttcaaaccta gctttttctc agaaaaacta 140820 ggcagcttaa aagtgatact gaccaatggg taccaaacta aatcactcaa atcagaatag 140880 ctattggtat ggccagaatg gatttttgtc aaagcttctt gttatttcta gtgtgcaacc 140940 agcactgcaa actcctgacc taaccaactt gtgttttctc tttcccctta tgtgctatcc 141000 catctgccac cagatagctc ttggtaagat gttacctggt gtgttagtcc gttttcatgc 141060 tgctgataaa gacatactgg agactagcaa gaaaatgagg cttaactgga cttacagttt 141120 cacatggctg gggaggtctc agaatcaggg caggaggtga aatgcacttc ttatatggtg 141180 gtggcaagag aaaaatgagg aagatgcaag agcagaaacc cttgataaaa ccatcagatc 141240 ttgtgagact tattcactac catgagaaca gtatggggga aactgccccc atgattcaaa 141300 ttatctccca cagggtccct cccacaacat gtgggaatta tgggagtaca attcaaggtg 141360 agatttgggt ggggacacag ccaaaccata tcacctggtt atctgaattc tgatcaaggg 141420 cacttcagga atttgggaaa ttttcaggta ctgttgttct caaacgtagc tacatattga 141480 aataacctag agaattaaaa aacagaaact cacttatgcc tgagtgctat accctcctct 141540 gcttacaagt atgttcagtt catatggggt atggcctgag cataacaatg tctgaagctt 141600 cataaatgac tggtgtgtgg tcaagttgca gaaccactgt gctagaacat cctgatgata 141660 aagatctgac tgtcagttca gatacaatct aaatatagag aaattcttaa cagaggatgc 141720 agagtaaatg acttcaggtg gaaagcacgt aaagtaaatg tgagaagaag gtcaggtggt 141780 gagtgtgggg agctggggaa agcatgctcc tgggctccct ccaacagaag ccacctgtag 141840 cctgggacca gtgtgctaga ggaacctgtt ttcaaagaaa gccagaagta tggatgcatt 141900 tttatttgca gcctgatgat ttttatattt tggcaactaa ttcactttat taaaaaatac 141960 tgaataagct caagaaatct gtgagctgga ttcagccaaa gcgaatgcca gtttatgact 142020 ttcctcttgg aaagaaaagt ctttcatgtt gatgtatcac attttcgcca gcttttctgg 142080 ggttatgttc tcagaagttt cgtttagttt gctctcatga aaggtgacgg taatgttcct 142140 cagctactta taaacatttg aagaaacttt tcctctgtat tcttagtttt atactcagtg 142200 aaaatataag tcaagtattc ataggtattt cactgttaga tcaccatatt gaggaatgag 142260 tgttagttca ttaatgccgt acacaaacac ccaaaccaaa atgtgcagtg cttgtggaat 142320 cacgatgaga taattagcaa tttcttcact tcccactgag caggatgagt tgaggattag 142380 cttctctcag tagattacac attagagaga aaaatgtcaa acagcaaagt aaaatgggac 142440 tctacgtctt cccacacaag catctccagt gcactaatga gctagcttcc ttgtcacatt 142500 cacaactagc agcagatgac ctaagaataa gtcagagaag ctttctatta gaggaacttt 142560 atcttgcctc taaatatata gtaaaaaagt gggtcaattg gtacttacag aagatatttt 142620 agttcaactg gagaaactta actattttag aaataaagaa cccctggaaa agttagtctc 142680 ccttattatg catggaaata aaagcacttt cttaatttga aataagtgaa ttttttactg 142740 aagaaattcc tttatgctgt cctcagtcca catattaacc ccatgtatca aggcctctga 142800 tctgccatct caaccacctt gtcactgtcc actaacctct tgctgcttcc cttctctcct 142860 tgttccacct agggttcaca gtctctgctt tgaatcagac attcacagga tcagacatgt 142920 gattcaggga cttagcaaga gggagtgatc agtgcattgg cctctgtttt atgacaaacc 142980 accaaaggac atgtgtcctc acacaacagg tacacttgct ttggcataca gaacctcccc 143040 agatggctgt gctggaggtg agtagatggc gtgaaggaat gcctctgcac atatttgtca 143100 tttcctgttt cccattgatc aaaatctctc caaagagcac actgtctctc cttctttata 143160 cttatggact atgacacttg gccacactga gaactgcaag ggtaatcaga tcccatacac 143220 tgcagtatgt attttcattg aagtgtacaa atgacagagg agttaacact tttggactgc 143280 cccagtcctc tggcagaagt actaatccct ctgagaaata catttctgtt ctttatcaac 143340 tgcccagtct caagtatttt gttacagaag tacacaacag attaagacat atgtcttctt 143400 tttaagaaat gcctaatcag gtcctttatc catttcagta ttttattttg ttttgttgtg 143460 ctactgagtt gcatcagttt cttatatatt ttgggtatta accccttatc agatatatgg 143520 tttgcaaata tttttgctca ttatgtagat tgctttacag tctgttgatt gtttcttttg 143580 ctgtgcagaa tatttttagt ttgatgcaat ctcagtttat ttttgcttgt gttgcctgtg 143640 cttttggtgt cataaacaaa atattttttg ccaagaccaa tatcaagaag ctttttcaga 143700 tatattttct tctagtagtt gtacagtttc attgtcttat atttgttttt aatatgatgt 143760 gagagaaagg tcaaatttta ttttttttgc attggattgc cagttttgcc agcatcattt 143820 attgaagaga ttatcttttc actgttgtgt gttcttggta tttttgtcaa aaatcagttg 143880 actatcagcg tgtgaatatt tctaagctct ctattctgtt ccattggtcc atatgactgg 143940 ttctatgtta gtaccatagt gtttttatta ctatcgcttt acaatacatt ttgaaaatgt 144000 gatgccttca gctttatcct tcttgctcaa tattgctatg ggtatttgtg gtcttttgtg 144060 gttccaaatg aattttaatt ttttttatct ctgtaatgaa tatcactgag attttggaag 144120 gaattgcatt gaatctgtag atcactttgg gtagtatggg cattataaca acattaattc 144180 ttttgatcca tgagtggaga atgtcttttt atctgtgtct tatgcaaaac aatatggaac 144240 ttctttaaaa aattaaaaat agaagtacca tatgactcag aaatccaatt tctgggtata 144300 tatctgtatt agtccgtttt catgcctctg ataaagacat acctgagact gggaagaaaa 144360 agaggcttaa ttggacttac agttccacat ggctggggag gcctcagaat catggcagga 144420 ggcgaaaagc acttcttaca tggcggcagc aagagaaaaa tgaagatgca aaagtggaaa 144480 cccctgataa aactatcaga tcttgtgaga cttattacct accatgagaa cagtgtgggg 144540 gaaactgcct ccatgattca attatctccc actgggtccc tcccacaaca tgtggcgatt 144600 atgggagtac aattaaagat gagatttggg tgggaacaca gccaaaccat attgctctgc 144660 ccctggcccc tccaaatctc aagtcttcac tttgcaaaac taatcatgca ttcccaacag 144720 ttccccaaag ttttaactca tttcagcatt aacccaaaag tccacagtcc aaagtctcat 144780 ctgagacaag gcaagtccct tctgcctatg agcctgtaaa ataaaaaaca agctagttac 144840 ttcctagata caatgagggt acaggtattg gtaaatacag ccattccaaa tgggagaaac 144900 tggccaaaac aaaggggtta cagggcctac gcaagtccaa aatccatcag ggcagtcaaa 144960 ttctaaagct ccaaaatgtt cttctttgat tccctatctt acatccaggt caggccactg 145020 caagaggtag gttcctatag tcatatacag ctgtgcccac gtgaccttgc aggggataac 145080 ccccctggct gctttcatag gctggccttg agtttctgcg gcttttccag gtgcacggtg 145140 caagctctcg gtggatcaat cattctgggg tctggaagat ggcggccctc ttctcacagc 145200 ttcactaggc ggtgccccag tagggaatct gtatgggggc tccaactcca catttccctt 145260 ctgcactgcc ttagcagagg ttctccatga cagccccacc cctgtagcaa acttttgcct 145320 gggcatccaa gtggttccac acatctgaaa tctaggcaga ggttcccaaa tctcaattct 145380 tgacttctgt gcacccgtag gctgaatacc acatggaagg tttggggctt ggaccctctg 145440 aaaccatgga gcgagctgta ccttgacccc ttttggcaat ggctggagtg gctgggacac 145500 agggcaccaa gtccctagac tgcacatagc acggggaccc tgggcccaac ccacaaacca 145560 tttttccctc ataggtttct gggtctgtga tgagaggggc tgccaagaag atatatgaca 145620 tgccctggag acatattccc cattgtcttg gggattaaca tttggcttct tgttacttat 145680 gcaaatgtct gcagccagct tgaatttttg ctcaaaaaat gagtttttct tttctactgc 145740 atcttcaggc tgcacgtttt ctgaattttt atgctgtttc ccttttaaaa cggatgcttt 145800 taacagcaac caagttacct tttgaatgct ttgctgctta gaaatttctt ctgccaggta 145860 ccctaaatca tctctctcca gttcaaagtt gaatctctag ggcaggggca aaatgccacc 145920 agtctctttg ctaaaacatg acaagtcacc tttactccat ttccctacaa attcttcatc 145980 tccatctgag accacctcag cctggaccat attgtccatt ttgctatcag gcttttggtc 146040 aaagccattc aaccaatctc taggaagttc caaactttcc tacattttcc tgtcttcttc 146100 tgggccctcc aaactgttgc aacctctgcc tgatactcaa tttcaaagtc actcccatat 146160 tttagggtat cttttctgca tcaccccact ctactggtat ttattttaca atttacaaca 146220 atctatgctc ttgaagctat ttacatctat tttgtctata ttgtggaaaa accataatgg 146280 tgtgatgctg tgtaattctt tccaaatcta ctttcagcga tgtcaccttc atactaatgc 146340 ccaggtctca ctgtattagt tcattttcac gctgctgata aagacatacc agagactggg 146400 aagaaaaagt gatttaattg tacttacagt tccccatgcc tggggaggcc tcagaatcat 146460 ggtggaaggt gaaaggcact tcttatatgg tggtggctag agaaaatgag aaagatgcaa 146520 aagcagaaac ccctgataaa cccatcagat cttgtgagac ttattcacta ccatgagaat 146580 agtatggagg aaacttatcc caagattcaa attatctccc accagatccc tcccacaaca 146640 cgtgggaatt atgggagtac aattcaagat gagatttggg tggggttgca gaatgaaacc 146700 atatcaatat ccaagaaaat aaaacttgga tctttaagta gtatctgcac tcctatgttc 146760 attgtagcat acatatatat atacacacac acatatatat agatatgatg ggatatttct 146820 ctgctttatt tttagcctta gaaaaagaag gaaactctat aattggcaac aatatgtacg 146880 aacccgaagg aacttatgct aagtggaata tgccagacac agaaaacaaa tactgcatga 146940 ttagatgtga aactgaaata gtcaaactca cagaaggaca aagtggcaac ctggtgattg 147000 ccagggtcag agtggggagg ggaaaattgg gagatgtttg tcaaagaata cagttttagt 147060 tatgcagaat gacattccgg tgatctaatg taaagcatgg tgactacagt ttacaataat 147120 gtattatatg cttgaaattt actaagatgg aagattgaag gtgttctcac cattccaaaa 147180 aaaaatggta attatgactt cactatatat atataatata tatataaaca ttacattgta 147240 tactttataa gatttctata tgtcaattat ccctaaataa agctgaaaaa atttaaaaat 147300 aatcccccga aatatatgta atatgaacaa taaatataag ccacacatgt tttttaaaaa 147360 tttgtcatgt ttttaccctg acagcaaatc tccaattgga tagcctcatt tcaagtgctc 147420 cacaggcaca acgaacaacc gactaccatg tgggccactg cagccctagg aaatacgaat 147480 gatgggctct gaaccaatct aagtggaatg actttaaaca gaaataatga ctcaagttct 147540 cgaacttaag tatgcttcag tatcatgtgc agagcttgtt aaaacataaa tcgctggact 147600 ccacacccag agactgattc aatagttctg aagtggggat cccaaatttc cttttctaat 147660 aattttccag gtgatgctaa tactgccctt caagagccac gggtgatgag gctttgggaa 147720 atcagctttg taacttttaa gtggaaaaag ggacatatag ttcctaaaca tgatataaat 147780 ctctcctcca ttacagtaac aattagtgct atagtagaaa agacaggtgg tcaaattgta 147840 cttaagatta caatttggtc actaaatgga ataacacatg tttttttttt tttttttttt 147900 ttttttttta gtcttgttaa ccaattgcag ttgaagatgc aggtatttga atattatata 147960 cacacatatg gcacatttaa cttagtataa tttgtgcatt aaagtaaaaa tcgagtcatc 148020 tacatttcca ttcactgaag gaaacatcta ggcataattt cagtaaacaa actggggagt 148080 ggaacgttat aacatgtgca taattcaatt tatttgaaat tgactgtaag tcctcattag 148140 gccttaagtc ccttttcagg tgaactatgt ctcacattta ctgttgcatt tctagttttt 148200 aatatcttgt atactgtagg tctctaataa atagatgcat gagtagtttt atttgtttca 148260 tatatttttg ggaattcagc cttcagttat cctgaaattt taatacagtg ttgaagtccc 148320 attgtgaggt caggagagtc tgtatgtatg taaagataga catctctcta aatcttttgt 148380 tcctttctgt aataagtatt aggaatataa tgcacttcag agtaaaagtc cagatgctga 148440 caagctactt ttaaccttgt gattctggat ggtctgatta tagagtccat ttccaaactt 148500 cctttcacta cacaggagcc tggagatgaa ttaaaaatta cctgatgctc tgaattgaca 148560 tttcacagtg cagtatcata acatattgta agaagagatg ctacacacga atttttaaac 148620 gattaaaaat atatctctac tgatgcaaga aaggaacttt atgaatgtaa cattttctca 148680 aaattggtct cataaatgaa gatcaaaaac ctttagtcaa gtggaagcca atttagagtt 148740 gttactgtca agcatctata acttttcaaa taaccaaatg ctattgctaa catcaggctg 148800 tagagtttaa attttcataa attcgactat ggagcctact tcattgccgg actagaatga 148860 caaatacatg ataacctaca tgggataatt ctttaatatt gttgtttggg gttgacaatg 148920 agaatccacc cattgactga gttccaactc ttttccaggc acttaatttt tactcactga 148980 aatacttgtc acagccacct tataaagtaa aaattattat ttatgcccat tttctataga 149040 gtatactgaa gctcagggag cttaagtagt tttctcagtg acatggatgg taattggtca 149100 aatctgtttt gaaaagttcc tcagactctg cagcctgcat tcctatgact gagctatgct 149160 aattagcaag agacagaggc ctttggtaca caccttttta tcagggaaaa gacttcttgt 149220 gaataaataa acactaagtc gtatcagtat acaactaaat cggccctaac gcaaggaaat 149280 ccttaatgat agcatcatta tgactctctt aaactatttc actggaaagg gaatttttaa 149340 ctctggggct ttgagagctg gactcagtct gaaggagctg ataacatcaa ggatttgtgc 149400 tggcaagggc aagtgcagtt gctccactat ggagatcata ggttggccct acagctcttt 149460 ccttacaaaa aaatctatag aaggtgattt ttatggcatt atctctcttg caatagacag 149520 tgaggaaatc ctcaattgtt ctatttctac agtttcgtgg atcagagtac aattcttgct 149580 tccttcgtgt ttaggctccg gaaagggatt tatcatgaga gcaaacaaat aaaaagaggt 149640 agttcagata agacaaaaga caaaagaaat agaagtatgc cccagaggag tagatttact 149700 atttattctt tcctgctttt gacatgagat ctataccatg atctttggcc ctgactacat 149760 tctggacaca cattttatat agtgtttgtg ccttagggga acagtggcta ctatgcctcc 149820 tacctgttat cattaatttt tctttttcaa aaaaaagtca atgaaccata tttcttaaaa 149880 acattcacca agctcctcag agaaaatggt ttactctgct agaagttatg tctcaagatc 149940 tcccctctac cccagacaaa ctaatctcca tcattatgac aattctccca tacttacact 150000 tgatgacagg tcacaaattt atgaagttga ctgagttatg gctcaacaat ttagtcttta 150060 ttttctttgg ggagaaaaat gatatgaaat catataagat aaaaattttg gagcaataaa 150120 tcactcaatt tgaaataaac atcagtacag gacataaaga tgtcatgaaa catttccacc 150180 caattgttta atccaccctc ttagtcaagt ccagagtatg acattatctt tcttttctgc 150240 tttgtgaagc caagctcatg tttgaaatga gtttaaaaac aaatgaattt cagacttaca 150300 gaatgttcat cttttagtgt tgttattaag aaagttaatg aaaacagtat tcttaccctg 150360 atgctccagg aaaggcatta gatccaaatg agtacataac attccatcat tctaatttcg 150420 aggttgatat ggatagccaa tgaaatccta caattgcaaa ttgcttcaaa gtatttcacc 150480 ataatgacta gactgcaatt ttgatgggtt actgataaac accaaaaatt aataataagg 150540 aaatagatga aatcacttgc attattgtat tcaatacaat cttagtaatt aatataattt 150600 ggtcataata tattcatttg tgaacttacc atatgcctat tatgcataga gcactgtgta 150660 aagcactgga aatttgtatt tgttcaacaa ataattactg agtacttctc tgaatagaat 150720 attactgcag aactggggat ataacagtaa aaagtcacac atgaaaaagg cctcccttca 150780 tgaaacacat tctaatggag aataggcaaa gcacatgata aataaattag agtatattgg 150840 aaagtgttaa gtattgaaga ggaaaaatat aaacaggcaa ggacagagac cattttaatg 150900 agatggtggt ggtgacactt tagactgtct gtagggtagg cctctcatga aaagaagtga 150960 catttgaata aagattggga agaagccagg aaattatcca tgagggtgtg tatggaaagg 151020 gcacacaagt agatggaaag aagggaaacg agctgagcat tttgtggaag agtaaggagg 151080 ccggggtcct ttactggatg ctgtgagggg gcgagaggta gaagattaag ccagagagat 151140 aaagggaatg gctgatatgg aaggtcatat gaggattctt gagagtcact ggaggatttt 151200 aggcagagta gagagctgat ctgatttggg aggacgactc tgactattgt gataagacta 151260 gaatgcaaaa ataaataatt tatggtccta atgaactcac acttcatttg aaaagttgaa 151320 aaggatatgg attcagcgta gtgagataag ttctattaga gtacagaggg ttgatagtaa 151380 cgggtaagac tcctgctcac tcctcagcct actccaatct ggcttctagc cctgtcatta 151440 cactgagaca attcttgaaa ggattctgat gacttttagg ttgccaagct ccatgtcctt 151500 cctctagcct catcttactt gacttttctg cagcaattgt aacattttat atcgccctac 151560 ttcttgaaat actttcttcc cttgttgacc atggctctac cttgtccata tttttttctt 151620 gtttctctgg gtaggcactc acttttcagg ctcactttcc tctccctagt aattgggtct 151680 tacaatttct gtccatagca gccacattaa caactccaaa gggctcactc acaacatagt 151740 tcaagggact ggtggttttt tgaagttgta tattgctgtc ttgagctgcc taaaatgaat 151800 aactcatttc tgtcttattt tttgtctcct tgttttgatt ttctttacat aaacaatttt 151860 aaccatgcat gaggcttcaa ataggactta attgcaagtt tatgtttcca tccaggattc 151920 tttgttgtgt aacatactca tattcagttg actgcttgac atctctggtt aagtgtcttg 151980 aatacgcctc aagtttataa tgtcccaagg tgaactcaag ggcctccttt tgtacagggt 152040 tcttctccag tgttctctgg cttgatggat aacactacca cccatgcatc ctgctatgca 152100 agacagaaac ttaagtattc ttctggatgc ccctcacttg cgtaccctcc aaatccaact 152160 cattatttat tatccaatct attgatattt ttcctcaagc catcaccata gtccatgtga 152220 ccatcgtctc ctgccctttc ttcctccagg agttttttct ccttactaca gtcacagaga 152280 ttttctaaac tgttaattga gtcatgtcac caatcaccta cctgtttaga acactttaat 152340 ggatttcctt ttttatctta gagaaacatg atcatagtct ttcagtttcc aaatatccta 152400 accattgcct acttccccaa gctcctcttt ctcttaggct ttcttcctct ttccacttta 152460 cattcaaact gctactagcc ttttaaaatg tttttgaaca gggctgttac gcatatgagt 152520 tgctctacca aagacgtggt gcttctttct tctatttctc atgcaaacat attagcttct 152580 actttattct agattttagc atagttatta catcttcttc taaccctgcc ttcaattccc 152640 aggtgaaata aattaccctt tataagctct catagtatat atacctctcc tgcagagaac 152700 ttttcattga gacctagact gctgccaagc acagtgcagg tcctcaaaaa taattgctca 152760 atataaggca agaggatttt ttggcaggtg gtgccatgct cttatttaac caggatatca 152820 gatgataccg tcatttattt acatattttt ctgaagcaaa taatcactga actacatcaa 152880 gtatcgatga ctatctggac cttgaaattt taggcaaaaa tattacttat agggtttatt 152940 tgggatattt aatattttaa ttagatttga aaatattatg gagacaagtt aaaacataat 153000 gtgcttagga gcttgtttcg aaggttacac aggtgttgct tgtactctaa tctcagaact 153060 ctcaagttct tttttttttt gagatggagt cttgctctgt cacccaggct ggagtgcagt 153120 ggtgtgatct cggctcactg aaacctccac ctcccgtgtt caagcgattc tcctgtctca 153180 gcctcctgag tagctgggat tacaggcacg tgctaccatg cccagctctt ttttgtattt 153240 gtagtagaga cagggtttca tcatcttggt caggctggtc tcgaactccc gactttgtga 153300 tccactcacc gtgacctccc aaagtgctgg gattataggc atgagacacc actcccggct 153360 agaactacca agttctaact gtgattctag acaaaaattt ccatgcttca ctttctcctt 153420 ctacaaagtt tcagtgaatg ttaaaaagtg aaaatacaca aataaaacat agttaacata 153480 cacccgacta gctcttcaaa aacattagtt ctgttttcct gcacttccca catgttgata 153540 gaatttctcc ttctcaagtg ttcttaccag ttaaggcagt gcttctttgg cttcggatac 153600 agcataacgt ttttgtctgt aaagatcttc tctccctgaa tctgataaac ttaaatttaa 153660 tagcatgtac acaaagtgac atagatcaag caggagaagc tagacaggat tctccacacc 153720 actgttgagg aaaggaaggc ataatgccat cacctgcaat tagaaaagtt gtctgagcca 153780 ttacaaggca ttttcaagtc tcccataaca ttttagcacc tgtaggaaag cttctctttg 153840 taagcaaaag gttaatagct gtgcttctcc agctgtttca cgtgggccag atgtctgagt 153900 agcccaaact acttaactgc atattagtgg cacataaact gcaggctgcc gcttgtcaga 153960 gagttgttaa tttccataga atgttgcact gaaagtcatt actatgtgaa ttacaacaaa 154020 tttgttaagg aggttatggt aagcattggt acaaggatta gtgcgtttga aaaaaaaata 154080 gaaggttcat cctctacgtg atctgagcga ctctctaagg tcttagtcac acacacacat 154140 gccccatgct ttattttgtg tctgagtttt agcttccaca ggttgccagt atccatgtat 154200 tgtgtgtggc caagacatcc tatcaaaact gaattgtata aaatgtcaaa aatcttatga 154260 aacttgttag atgtttatgc ttattgagga tattttgtta tgatagtcaa ccataatatg 154320 gagttctata acttaaaaat aacgatcagt gcatgtactg aattcaaact aagcttcaga 154380 ttcagtactc agttttctaa gtgtttatct cttgtaggat agggtctgca aggtgaatct 154440 atgggtcaca tctcacatat ggcccattct cacacacacc atctcatgta atcctggtaa 154500 tgtttgcaaa aggccattgt cgtcgtcgtc gtcttcttct tcttcttctt cttcttcttc 154560 ttcttcttct tcttcttctt cttcttcttt cttcttcttc ttcttgttct tcttcttcct 154620 cttcctctgc tttcttcttc ttcttcctct tcctcttctt cttcttcttc ttctatcttc 154680 ttcttcctct ttttttttct gaaggtggaa cagacctaga agctggagtt cagtgtttgt 154740 tggtgacaca ggattttaac ttcacattta tgacttcaca gtcgctgata ttagtgttga 154800 tttttttgtg gattagtata gagtattttt ctacaactac tgatatcaga caattgccag 154860 aatgaggatt ttgttggcag ggctagcaag gaggaagggg agcatttcaa agctgtgtcc 154920 agctgaatga gactgcctag ggcttaaggg ggcagcctca ctcagggagg ttctaatgat 154980 cagtcccttc tccttgacca atgtgtgtgt gcatttgccc caataaacag tcctggtcat 155040 tttgaccgaa gatatttttg aattagtctt atatgctatc tacataaatt gatgctatgt 155100 aaccactaca tacaatggag tactattcag ccataaaaaa agaatgagat cttgtcattt 155160 gaaacaagat aaatgaaact agaggtcatt atgttaagtg aaaaacctat aattttaaaa 155220 cagaattgtt cttttaatga gacttaagga atattaattt tatttttaaa atttcacagg 155280 gagaggagag ctaaagtaag tgtgtgtgtg tgtgtgtgtg tatgcataca aacataggtg 155340 gaagatttgc taatggcaga taattatttt tccttaatta cctcacttag ttattttatt 155400 taaacattga aacaattttg ctaagtcggt attatctaca ttttatagaa acatttagaa 155460 aatgtgaata ccatgcctgg ggttgaaaat agagcatttt gttttgcttt ctttcacctt 155520 cttcactttg cttcttaaag gatataatct tctttttaat caattgtggt ataacatata 155580 tattttaatt ataatagaaa tgtttatttc atatgttgtg atcataaaaa cttggaaaat 155640 aaaaatagaa acaaattcaa attacgattt gtagtttctt ttttttaaca tgtcatatag 155700 cttattgctt atttctgaaa aaaaaattgt cttggaacct tccaagttgc tgcccactct 155760 gaaatgtttt actctataca gcctttgttt ggggcatgta actttctttc tttttttatt 155820 attatacttt aagttccagg gtacatgtgc acaatgtgca ggtttgttac gtgtgtatac 155880 atgtgccatg ttggtgtgct gcacccatta actcgtcatt tacattaggt atatctccta 155940 atgctacccc tcccgcctcc cccaacccca caacaggccc cggtgtatga tgttcctctt 156000 cctgtgtcca agtgttctta ttgttcaatt cccacctatg agtgagaaca tgcagtgtct 156060 gctttttttg tccttgccat agtttgctga gaatgatggt ttccagcttc atccatgtcc 156120 ctacaaaggt cataaactca tcatttttta tggctgcata gtattccatg gtgtacatgc 156180 gccacatttt cttaatccag tctatcattg ttggacattt gggttggttc caagtctttg 156240 ctattgtgaa tagtgctgca ataaacatac gtgtgcatgt gtctttatag cagcatgatt 156300 tataatcctt tgggtatata cccagtaatg ggatggctgg gtcaaacggt atttctaatt 156360 ctagatcttt gaggaatcgc cacactgtct tccataatgg ttgaactagt tcacagtccc 156420 accaacagtg taaaagtgtt cctatttctc cacatcctct ccagcacctg tttttttcct 156480 gacttgttaa tgatcgccat tctaacttgt gtgagatgat atctcattgt ggttttgatt 156540 tgtatttctc tgtggtataa tatatcttaa gagtcttgtg tctgtcatta caacttaaat 156600 aaacttatta gaattgtaaa cttaagcatt tacatgtatt ttacctagat attgaagtat 156660 tcagtcttta gaaaaaatga taaagagggg gaaaacatta gtacaaaata agatatacta 156720 acaaaagttt gaaacgatac aaatgaggca atttaccagt tacctaagaa tgcacaaatg 156780 cattaaacta acagggatgt gttttaatag ctgtgatatt ttaagaagtg ccgatacagc 156840 tattccattt cttattcaag tatctctaag gcacttctag gtacacataa ctgggagaaa 156900 attttaaaaa ccaaccaaac aaaagaaaac ttttcctatc tgttccaaac acacatgaca 156960 gacagattaa aatctatttt atgttaaaaa tataattgcc tttaaaaagg agagaggaaa 157020 tatctgctaa taccaaagac aaagggtaaa taaatttaat gcctatgagg gggggaagaa 157080 ggcagatttt ccacaaagta acagcgatta ctttgacaat agattttatc actaaaaata 157140 aataaggtca ataaactatt atccttaaag tattcagttt agaatccttt atgatagtta 157200 taccattata ctatgtggtg ggtgtcagag tgaaggcatt taagaaatat aaagactata 157260 aaagcttatt atccacccat ctggaaagga ccactaaggt tgtagctgag gaaacaatac 157320 tgtagtttaa aaaagtaagg ttcaaaataa aatcttaaca gcaaagtgtt gaaacatgct 157380 ttattagttt ttcaatactg tggtaataca aactaccaca catgtagtaa cttaaaatta 157440 acccagattt tttatcttat agttgtggag gtctaaagtc caaaatcctt ctcactgggc 157500 caaagtccag gtgttggcag gactggcatt ttgggaataa ccttggatag aattcttttt 157560 cttgcctgtt tcagcctctc aattctactt gtaattctta ggtttttgct cctatctcca 157620 tcttcaaagc cagcagtggt gcatctttta acctccgtga cttctgcttt catggccaca 157680 tctccttgtc tcactctttt gcctccttct tttctgtata agagcctttg ggcccatgca 157740 cataattcag gacagtctct ccattgaaat atccttaatt taatcacatt ttcaaagtct 157800 ttttgccatg taaggtaaca cgtttacagt ttccacagat tagggggact aatccaactt 157860 tgggggacta cttattctgc ctaccacaca tattgataga gctaaaaaaa agtactatac 157920 aaaaaaaaag aacagtgatc ctgttttttt ttaaaacaga gcaagagaga ggaactacat 157980 tagtaatgtt agtaaataaa catcaaacta actgtaaaga aaataaaagt taaaataaaa 158040 gttaaaaaag ttattcaaag tcaaagtatt aatacactat tgagaaaatc aatagagcaa 158100 agagttggtc ttttgagaaa acaaatatgt ttgataaact gctagaaaga ataaccaaga 158160 caaagcatgt ataatgcaca aatcatccat atcacaatac gcatacataa aaagttaata 158220 agagattatg aattgttata tatgaatcaa tttggaaact tagatgagat ggataaaatt 158280 tcccaaaaac tgcaacttag tagaaaatac accagaagaa atataagttc taaatagtcc 158340 tatatctatt taaaaaatga atacctaatt aatgaagaaa acttttgtga gattagaaca 158400 aacttgaagc ccaaaccagt taagacatta taagaaagga gaattgctga cctgtctttc 158460 tcataagcgt agatacaaag aattctggat ggactagcta tttatttatt tccagggata 158520 tattaatagg atgatacacc aaaaataaat tggttttatt ccaggaacac aaggttggct 158580 caacatttaa aaattgaaca atttaactta tcatagtcgc aaaacaaatg agagaataca 158640 tctgattatt tcaacatttg caaaaagttc acttgttgta atttagtacc cactcatgac 158700 ttgaatgtgt acttagaagg tataaataaa tgtatagata aattatgaga actactgagt 158760 gaatttagta agatcattgt actcaagatc gataaagaaa aataattttt gtatgtatat 158820 tgccacaaag aactataaaa tttgaaaatc ggatgccatt tataatacca taatataact 158880 ctagaaaaaa aactaaaaaa cccttaaaag gtattaacaa ggagaactac aaaatattac 158940 tgacagaatg tacaaaagac ttaaatatat aaagttatat tctatgttaa gcagtaaaaa 159000 actcagcgaa attaagttgt gtttttccct aaattgatcc attggtttac tacaatcata 159060 atttaaatct aagctgcatt tttggctgaa aaatttcaaa ctgaatctaa actatactgg 159120 gaaatgcaaa agacctagga aaggcaaaac actcttgaag aagaaggtgg acaatttata 159180 cttgtgaagg tgttgcattt attatgatac tctagtaagg aagacagtgt agaattagtg 159240 taaaaataca caaatagaac aataaaagaa aaaaaataga ctttccaaca aattatgctg 159300 tgtcaattaa atattcctat agaaaaaatg aatcttctat tttacaccat atgtcgaaat 159360 caattttagg tgaattgtaa atctaatatg aatggcagaa caataaagtc ataaaagata 159420 atatgtgatc atagttttat aatcttgggg taagcaaagt tgtttttttc aaaactggac 159480 ataaacaatt ctaaccgtaa agaaaattat tgatatattg aattatgcta aaaagacatt 159540 ctgctcataa aaatatatga ttaagcctgt gagagtcaaa ccacaggaga gagaagattt 159600 ctgaatttct agcaatacca agacaaaggc atacaagaca attttaaaac tgggcaaatg 159660 cactttacaa taaatctatc aaaactgcta gtaaatgtga caatgtgctt ggcatcatta 159720 attattctag aactatgacc tgatgctaat gcctgcatat taagagtgaa tacaattaaa 159780 aacagaagaa aaaaactctt tattatcaaa atttctcata tcttactggt gggagtgtaa 159840 attggtacag tccctcaaaa atctctttta cagatccact aaagctaaac atttgcgtac 159900 tgtataaccc agcagttcca ctgtcaggta tatgccccac agaatgttat gcatatgttc 159960 acaaaaatgt atacacagga atcttcatag gtgcaatgtt catgtgactg taagtgtaaa 160020 caattcaagt gtttataaac actagaacag ataaaaaatt ttggtatgtt catataatgc 160080 aatactataa agcaatgaaa atagacaaag aattgccata tccaacagaa taagcagaaa 160140 tgaatacaga caacatgatt ccatttatat caattttatt tatttatttt tacttatttt 160200 ttcttttatt tatttatttt tttgagatgg agtctcactc tatcacccag gctggagcgc 160260 agtagtgcaa tcttggctca ctgcaacctc tgccacccaa gttcaagcga ttctcgggcc 160320 tcaacctccc gagtagctgg gattacaggc acatgccacc acacccggct aatttttgta 160380 tttttagtag agatggggtt tcaccatatt ggccaggctg gtctcagact cttgacctca 160440 ggtgatccac ccaacttggc ctcctaaagt gctgggatta caggtgtgag ccaccacacc 160500 cagcctcatt tatgtccatt ttaaatgaaa ttataattaa tctatagttc tagtaactta 160560 tatgtttctt taatttctct ttcttatatt gacattaata atacccttga tttttattag 160620 aacatgccta ctttatcttt ttttaaaata accttattta caactgacct atttaattta 160680 ggcagcatat aactaattat ttttggtttg gttttatttg atataatctg ataatctttt 160740 taactcattg agttgagttt aactcatttt tattttaatt ataattatag gtatattttg 160800 ggtcagaagt tagaaagtat ttctctcttg tgataattag aatttgagca gaacttccat 160860 gttgatataa tatttcttga tcagagtggt aataaaattt atcgagatgc acatttaata 160920 ttatgcacgt tttgaaacat acataatatg tatgccaata aaatattcaa cattttcata 160980 aattaaatgc cttaatgaga taaataatcc aagaactgaa gaaaccactc taacatacat 161040 agataatgtg ttggatgtga tattataatt ctaaataaaa taatatcctc cccacattat 161100 aagcaaaaaa aaaaaagata aatttaaaag gaaaatatga aagaggtcac atcaaaagta 161160 ttagaagaaa taaagaagaa tgcatatgtg gcatcaaggt aaataatata ttatttagga 161220 agacagcaaa agaaaaatca ctaaccagcc gagtgtggtg gctcacgcct gtaatcccag 161280 cactttggga ggccgaggtg ggtggatcac ctgaggtctg gagttcgaga ccagcctggc 161340 caacatggtg aaaccccatc tctactaaaa atacataaag tagccgggtg tggtggcggg 161400 cgcctgtaat cccagctact tgggaggctg aggcaggaga atcacttgaa cccgggaggc 161460 agaggttgca gtgggctgag attgcgccat tgcactccag cctgggtgac atagtgagac 161520 cctgtcaaaa aaaaaaaaaa aagaaaaatc actaaccata gaagaagtac agtgcaatct 161580 aacttcattg aaatcacagg cttttttaac aacaacaaga tgccataaac atacttaaag 161640 gaaataggat caattaggaa aatatattta ccatgtatat aataaggtta gaatttttga 161700 tagaaatgta aattagtata aaatttgaag gacaaatttt aaatatctat taaaatagaa 161760 aatgaacagc aaaaaatata tgtatgcatg tgcatgtatg tgtgcatata tatgtgtgtg 161820 tgtgtgtttg tgtttgtgtg tatatatatt tatattcttt aaatatgctg tacacaggta 161880 caatggaatg tttgttggag caatatttgt aaacctaaaa atacatatgg cctaaatagt 161940 cttcaaaact gctaattact ataatgttga atacaattta aattcctata tatcaggtga 162000 aaagaagaat gtgtctcaat agttacatag gaatagacat tacagtacat tttgaatgtg 162060 gcgtaatatg tctatagtga tcttatttat ataaattaaa aataatcatg ctcaaaaagt 162120 tatacagatg gtccctgact taagatggtt ccacctacag tttttcaact ttacaacgat 162180 gcaagaggag gatctgtatt tgtaaatagg ttgtactaaa tttaaacgaa tgctatacag 162240 ccatccctgg gaatctgcca ggtattggtt tcagagcacc cctaccctat accaaaatct 162300 atggatgctc aagtttctta tataaaatgg tgcagtattt gcatataacc tatgcacatc 162360 ctcctgtata ctttattttt tgtagagaaa aggtcttgct atgtcaccca ggttggtctt 162420 gaactcctgg cctcaagtga ccctcctgct ttggtttccc aaagtgataa gattacaggc 162480 atgagccacc attccccacc ttgtacactt taaatcatct ctagattatt tgtaatacct 162540 aatacaatgt gaatgcaatg ttgctacact gtatttttaa aatttgtatt tttaattgtt 162600 gtaatgctat tttttattat tttttccgaa actttcaatc tgctgttggt tgactttggg 162660 aatgtggaac ccattgatac agaaggccaa ctgtgtgtat atagatatat atacacacac 162720 acatacatat atatatatgt gtttctcaga aatgactctg tgtgtgtgtg tgtgtgtgtg 162780 tgtgtgtgtg taaaaagcta tgaaatgcag tcataatgca ggttgcttct gacagggctg 162840 aacagtggga aaggaacaag ggagaagaat gaaacaggaa tgacacagag tacgatgcta 162900 cataaaaact taaattagct tttttttttc ctaatttgaa aatatgaagc aaatatttaa 162960 gaattttgaa tgtctatact tcttgaaggc atgttttaac atgtgataat gtagttttta 163020 cttataattt aattcaataa ttatcagagg gatttttttc tgaaataaat agggaaattt 163080 aggtagctgt gagcattgaa gaggttattt ggagagaaga tatgaaaaaa tcaactcctg 163140 gacctgggta aggaaagata acttgtgctg aaacaaaagt acagagagcg cagatacaca 163200 ccccccaaga tttcagctta atcttactta tatcatcatc gagttgggag aaggagaaga 163260 aaaagagggg aggcctgtga caataattct tttattcata tatttactca tcaaaaaata 163320 cttattgaga aagtgctaga taccctgtcc taggtattat caatttactc atgaaagctt 163380 cattctgtct caaggaattg tgatgattcc tgtaataaca gcaagtgcaa agtgctacca 163440 aatgatagaa gaaatagtct atttgtggat attgaagaag accgcacatt ccagagggct 163500 gttgaaaagc acagatggaa agagtggaaa aaaactgcag actaccccat acaaagacac 163560 acagtcatta aaggacaggg acatttggtc agtgaaacca tcttgttctg ctggaacata 163620 gacagtcctt gtgaaaacca agaaccagca gaattgaggc tgaaaatcag gtgaggtctt 163680 gttgccaact aacccttcat actgttccca gttttatggg tgatgggaag ccactggtgc 163740 atttccaaac tggaaatgac acaaggaatt gctgttttcg aaagagaatc caatcagctg 163800 tgcaaaggaa gttctcagga gagaccagat atagaaagac aaatctgact aatacatttt 163860 tttttcttaa aaaagagact agaaaggtaa aggtaagtgg atggatagga agagagaatt 163920 tatgaacaaa agtagtatgg tatggtgaga tttgatggct atttggttat gaggaggcag 163980 ggagaataaa caagtgataa tgactacatt ttttagtttt ggaaaagcac ttgtgagtca 164040 ttcagggatg ttcagttggc agatggaaat agaaaaacca attatgagtc ttctgctcat 164100 acattttagg aagtctgcat tgaagctagt tctcctttta ctcagtgatc ccatttgagc 164160 taataagctt cataaccact actcacttca taaccactac tcacttcatg tcatggctct 164220 ggcctgtgaa agggaggttt acctaatgaa gtaaaagtta ttcttctaaa gtatagtcac 164280 tgttgataca tttctcagga acattctttt tcttttgaca gcatgctatg aaataaaaat 164340 tgcgtgcaga cctggaggaa tattaacata tgaagacatt gggggaaggt tattgattga 164400 tttactgaat ggtctgattc aaatgaactc ctaatatata tagaccatct cagaattaat 164460 caccttctct actcttagag tgttccttat cattcaggta gcaatcattt gaacacccat 164520 catttttaaa aaatgaaaaa gaaaactgta actaccttga caactggaag catgatttta 164580 agtagctgaa ggagttactg gcttaagtta gaaacaaacc agattggaaa ctaggtataa 164640 agtaattaat ttcttccatt ttgagaagtt ggaaggtctc actgagcttt tgttggttac 164700 ttattcatat tgagaaattg attatttctt ttgcctaaag tcaaagagct ctgaagagac 164760 ctagtcaaga tttggatgtt ttgaatacag tcacaattat ggtctcagaa atactttaaa 164820 acacattcat cagtcatgct cttattcaga atcagggcac aaattttaaa caataaaatc 164880 catgtgaact taaaaatatg ccttcgagtt attgaacatc taattaaatt gcttatttct 164940 cattatgcct tctctaacaa taaatgattt tcattcctga atcccaatgg gattttcctg 165000 gtccacttgt aagttgttta tttagataca caatgtgaat ctatatgttg atttattttg 165060 taatggttca caggactggg ctactttcct ctgagtgagg gtaaaattaa tcagtaggaa 165120 atgaatattg tcagtgtcaa tgattataag aggaaattat atgtgggagc aagagagaat 165180 gaagcagatt atttgtggtt aggagttaat tcagagggat ccatgcataa tctccatctc 165240 cgccaatttg gctgttttac tcctgttgcc atcatgccag catgggatgc tcaatatcag 165300 aggctggctg acatcaactg gatgaaacca tttgttgatt gatggtttat tgtttcttcc 165360 atggtgaatg attgctactg ggaaataata tgggatacaa agatcttcaa acattatgct 165420 cacttccata tatctctctc cattcagatc tccttttccc cagtctctaa tctttctccc 165480 tgcaggcacc tgtcccattg tccagtccgt tggtcatggc tcatgaattc acacataatt 165540 ctaatcccag actatttctc ttcccacaca caatagatga ccagttttac tgtttgaagc 165600 tctgcccatt gggagcaatt ttctttacca ctctatttta aggtcactcc tgagaaagga 165660 ggtaatgcaa ctacagacta tttttacctt gcatccacat atctaagcaa attatccatg 165720 agctaagcta ggggtatttc ctcctccttc atttggttgt ggatctctca tagggccact 165780 ggagtgatct caagagagtt ggcactggtg cagcagtgag gagtgtcaca gggctctgag 165840 atgcttgctc atgcagcttg cttgtgccct cttgtcttgc ttatgcttag ccattgatgt 165900 gactacatac attcatctga caccatgtgc catataagcg atgcttaatc ttaggactca 165960 atctggacag aacccactca tggcagggct gcttacatca tagtctagat ctctgaagag 166020 cccttttctg ttctgggtca ccctcaaatc tgccagcctt ctgcacgatt aaattatagg 166080 ccatagcaat attctcgagt gtagaaaacg ctgtttccag atcctgaaga agtctaccag 166140 gtagaatgat tccttctctg tggtggtagg tgagagatgc aataatttgc tttttacatt 166200 ggctaagatg tcccatcata tacctaacct atgtgtccta aaaattataa tgagatgaga 166260 ggcccttgaa tcttagcagg attcatctcc ttcactcaaa agtgcacaca tttactaagg 166320 tttctgacat gtcattgaaa ttgcctttca aaaattgtaa cagttagata aatctaacat 166380 agctgactct gtcttgtttc taacctcgca agcaaactgc ctttgcccat ccgtacatgt 166440 aggacaagct aactatggga agaatttagt ttatagttta aagcaagaat gatagtagtc 166500 tcttcccaaa actaatctcc cacttattca ggtactgaag tcgctccttg taaagctaat 166560 aaaaggccat aattttagaa ttacagtaag atcctgaatt ctgctaatgc taggcatagt 166620 taaataataa ctagtcattg tctcctaata gatttactgc tcaggagtca tgtagccaga 166680 ggtcacaaaa tttgtaactt ccctaattgc cccgagagac agcattgcta ttgcaaaacc 166740 tgactggtgt ttgcaatatt ttttagagtt tgcattcttt gggccaacag atgccaacca 166800 ggctcatgac ccatatcaaa aaactgactc aactgctcct gtgacaaccc agaaactgac 166860 tcagtgcacg aaggcaattt tgatgcccgt atgatttcat ccccaaccaa gcagcaaatc 166920 aaattccata gccccttgcc caccaaactg tccttaaaaa aaacctcacc tccaagttct 166980 tagggaggca gatttgagaa ttatctccca ttctcctcac ttggctggcc ctgtgattat 167040 ggaactctgg gctgcaacac ctgctatgct caatgtattg gctgttttgg aaacagtggg 167100 caagaagaac ctgtcaggct gttatgttcc cagacagaac tggggtccag ctgcttgttc 167160 tcatggttca atcataagat gcaaacagac tgggcaagaa gggagtttct gcaaccagtt 167220 acagggagaa aaccagaata actcaacaga ccaactcaaa gttacaagtt tttctccagt 167280 gcttataata cattcaaacc atatgcctac gtgtgggaaa gcacctacaa actgaagtgt 167340 ttcactctgt ctaatcttta actagggttc agatctggaa attacttcag agcctaggaa 167400 caattatgta atctaaagtg ggtcttggta caaggtgtgc aagaatgcct ccttttatta 167460 attaaactct aatgtctgag aaagcccagg tggggtctta atggacttgt ttttacattc 167520 taacccttgt actaaggcac cagtttctcc agttctttaa tgcttaagtt atacactcat 167580 cagatttaca ctaaggtggt ggtgaaggat gactgccctg gttgctaatg gagacctggc 167640 ctgccacaat tacactagtt atttcttact cattcctcag ttagcatcat atcattgatg 167700 gagtggatca tgtgatgttg agtgagatgc atagataatc tagatttcct tggactatat 167760 tttaacagag gttgggggca gttaacataa ttgtgggaca aaacttgaaa catttgctgt 167820 cgttcctgcc ttgtgaatgt gaattttttc agaactgctt tttctgctaa gaatagaaaa 167880 gagtgtattc aataaatcaa tggccaatta taggtacctt agaccaagct aatgtgcttt 167940 tgcaaggatt ccatatttgg catggtggct gcaattgtgg ctactattac tttgtacttt 168000 gtagtggcag cttaatatct tccgttggga tctgtttggt tactgcagga atcaaactgg 168060 taaatcatgg tgtttgttgg gaccaccagc ctatgtcctt tagatcctga aggtgcttct 168120 attaatactt tctgccatcc atcccctgag agtcaccagc tgcccaatgc aatattgttt 168180 tagaaatacc atctagataa tgtaactctg tgtcccatca tgcaaggctt ggtaatatat 168240 ttacttttgt gtttactttt ctttctaatc cattatctat ttctcagcca atatgagctt 168300 tttaaaacac aaatgagatt atttaatttg tctgctaaaa atccctcaat ggctttctac 168360 tgcccttcca ataaaatcag aatctctgat taaaaactaa caattcttat gatttttgac 168420 cctgactaga tttttggcct taaaatacat gatcgtccac ctctagcaca agcctccagt 168480 cataggattt tttgcatctt aaacacagca cctttcccat cagggcattt ggacttgcct 168540 ttccctccgc taagagtgct tttcccagca cactgaagga gggcttgcac ttcatctttt 168600 tattttcaac tcaaataata catcttcatg aggtcttacc tgaccacata gtccctgaaa 168660 ggttcaccga aaagtcactg gcatgaggca cattgattaa taggagaaga gacataaaca 168720 tttatttaac ttctatacgt gggagcctta agaatgaaga ccagcttccc aatgagttac 168780 agaaatgtat ataccatctt gaggccacag taaagaatac agactcagaa catggccaga 168840 aactggttat attggtaaat caggcttagt gaaaagacag gttatgagag agagaaagaa 168900 gcttgactag caaatgtgac cttgttatgt agatgaagct tcccttagaa tagagggtaa 168960 atgtttctct tcatacttta aaggtgtcag actctccagt ttcttcagga tctggaaaag 169020 cacaggaaag ggaggcagcc tggctgcatt gaaggaaatt ctctacagat ccaaattttc 169080 cccacaaaag acagctttgc agggccactt ttgtttgcta gccaagtggc agccatttca 169140 aaatatgtca aaaaatacat tttgagggta agatcattaa atttccttta ccaccatgat 169200 taaggtagca gctccattta tatttccttc agctagtttt tctgcgtatc cacttgcctg 169260 tttgtgtgtc cacactgact agaatatgag ggcagcagca ggaacaacag caggacctag 169320 gagtggttgt gacttctttt gatctcaagg aggttcttct aaatgttgat tctactggaa 169380 tatgacatac cagtagacag atggacagac atctaatctg catagatggg atttggagtt 169440 attgtaatct caaattagga agtcagagag gttctttata tcctaatggg tgaagctagg 169500 tatacaagtt tcatagatat ttttgtacgt atcaactttg gtttaaaatt aatctagtac 169560 ttctattttt aaataatgat aaatgtatga catatagaca tgcacttgcc acccacaatt 169620 aatgaatgtt atattttttc caaacttttt aatgaagccc tttattccat atatatgaat 169680 aaagggcttc attaaaatat atatatataa aattttatat atataatata tatatttttt 169740 aaagaaaata attccaggta tagttagagc aaatctccct catgtcttac aactaatttt 169800 ctacttcccc acgcataatg gatctcacag cattttgttg cattcctata cacattcaaa 169860 tttttaaaaa atatatatat atccataatt tcttgtattg ttttgtttaa taatttatat 169920 aaatgcagtt acatcaaata tattatgctc caacttgctc atcttaaata atagctttat 169980 attctgagag aaatccacgc tgagcatgtg actctattta aatcttacct gttgaaaggg 170040 cccttatgcg cagagacaga ctgtccccct gtaggtccta agaggagttc agtaactgcc 170100 ctgatctctg aactcttggc aggtctccca gactcccagt tcttgtcagg acgccctcct 170160 cccaattgtt ctgccctgaa cggattgtgt tttctccact atctgccctg caaccaagca 170220 agcgttatct ccccattttt atcatcacag aaaggccagc cttccaggac atctctaatc 170280 cttcaattct aaccccacat gcattcaata catcaacgtt tctcaatatt taatgtgcat 170340 attaactact tatttttttt ttttttgagt ctcactctgt cacccaggct ggagtacagt 170400 ggtgtgatct tggctcactg caacctccgc ctcccgggtt caagttattc tcctgcctca 170460 acctcccgag tagctgggat cacaggcgtg tgccaccatg cccggctgat ttttgtattt 170520 ttagtagaga cggggtttca ccatgttggc caggctggtc tctaactcct gagctcaggt 170580 gatctgcccg cctcggcctt ccaaacttct gggattacag gcataagcca ccacacctgg 170640 ccttgaacta ctttttgtca catgaccttc tccctcttca agtccagcaa cagagaatgc 170700 tcctcacttt agtttcctct tgtgcttaaa gtctctgtca acaggacaaa cttgtccata 170760 ttgacgactc acctgattgc gtcagggtcg ctagaggagg atttcattat cttaagatta 170820 acttgggagg ctgaggcagg agaatcgctt gaacccggga ggtggaggtt gcagtgaact 170880 gagatcgggc cactgcactt tagcctggga gacagaggga gactctgtct caagaaaaaa 170940 aaaaaaaaag aataactcgg tgagaggtgg ccaagatggc ttattagaag cagctagtgt 171000 gtgtggctct cacagagagg acgggaaagg gcgagtaaat acagcacttc aactgaaaca 171060 tcaatctact cgcattggga ataatcaagg gaacaactca acccacagag aatggagaag 171120 agcaaggcag gacactggac cacctgggag tgacacagag caagaagaac ctcccctgcc 171180 cagggaagca gtgagtggat gtgtgaccct gggaagccat gcttttctgg tgagtctttg 171240 cagccctcca gtcaggagat ccccttgtga acccactcca ccagggcctt cagtgtgaca 171300 cacagagctg ccgtggagtc tcggcaaagc agccactcag gcatatgcaa acagcaggaa 171360 gccttagatg ctcaggcttt ctgggcttct gggcaaaagt agctgcaact ctagcaaagc 171420 aggagggtag atccctgtac atatccctag gaaaggggct gaatccagaa ggcctagcag 171480 tgacagtctg catgttccac ttccacggga ccttgcagga taagacccat tggattggaa 171540 ttccaaccag tcaccagtag cagcgttaca cctccctgag acagagcttc caagaggagg 171600 ggcaggccac catttttgct atgtgggtga cttagtcatt ccaggcttca agctttggag 171660 agttcaagcc aactaggggt ggaaaggatc ccacagcaca gcacagctgc tcttaaaagt 171720 gtggccacat tgcttgttta agcaagtcca agatcccgtt actcctcaca gggtgggacc 171780 ttgcaactgg ggtctccagc caccttctac aggtgtattt gggctggcaa cgggcttgta 171840 acttcctggg aaggagcttc cagagtgagg ggcaggccac catctttgcc attttgcagc 171900 cttcactggt ggtaatctcc aggtaatgga aaatccaagg caactaggga ttggagctga 171960 cctgcagcat actacagcaa ccctataaaa aagatgtcag actgttacgt gggtgcccat 172020 tcccatatct tctcaccagg tgcatcctcc aggcctgagc ctccagccac cctctgccag 172080 agctatcaac tccctaggac agtgccatca ggagcaagtg aaatcctctc tgtcactgcc 172140 tctgcagtcg aactgccttt cctagtctca gactgatgaa ggattgaaga ccataagtgc 172200 cttatgcaca cctccaacaa ggtgcagtca acccaaggag aggaggccag ttcatcaccc 172260 acgggtcccc cacatacccc actgctcatt accagactgg gaacccctgg cttgggccca 172320 cagcacaggc cctccatccg gggctgattg cactgagtga ttgctgacct taaatctctc 172380 tggggtggag ttcccaggag aaaagcaaaa gactcgctgc cataaccagt actaagttct 172440 cttcctttac tgactctaag ttgggaagga acataaacac tgagattgcc acagagtggc 172500 agtggacagc ccaggcatgc caagctggta tctacagcag cactcaaggg ggagaggaac 172560 ccatactttc aggacattga gaggcaacat ggctacaact gaaggaaaca gagcaagagt 172620 ctatcagctg gcaagtatgc ctgagtgaca cctactaaat cacaccccaa agcttcaaca 172680 ccaaaaatac cttgctaaca cgcccccctc tgaaaccaga gacaaggagt cagcttcaaa 172740 taaagacccc gcacaaagcc tttacccagt gagaatatcc ggcaaagtct attgactgta 172800 ctcaatctat actgcagtta aaggaacaca cacatgcaga gatgagaaag aaccaatgca 172860 agaactctgg taacccaaat ggccagtatt ctatgtcctc caaatgacca caccatttct 172920 ccaacaagag ttcttaacta ggctgaactg gttgaaatga cagaaataga attcagaata 172980 tggataggaa caaagctcaa tgaaattcag gaggatggca gaagccaatg taaggaaact 173040 aagaatcaca ataaagtgat gcaggagcta aaggatgaaa tagcgggtgg aaaaacaaac 173100 aaacacaaca cccaatgggt ctgtcagagc tgaataactc aatacaagaa tttcacaatg 173160 caatcaagta ttaacagcag aataaaccaa gctgaggaaa gaatctcaga acttgaagac 173220 ttgctctctg aaataagaca gacaaaaata aagaaaaagt ttataaaatg tgataaacaa 173280 aacctttcag aagtatggca ttatgtaaag aggccaagtc tatgagtcat tggcatactt 173340 aaaagggatg gggagaaagt aaacaacttg gaaaacatat ttcagggtat catccacgaa 173400 aactttccct atcttgccag agtccaacag tcaaattcag gaaatacaga gaatgcctgt 173460 aagattctac atgagaaggt catcccaagg tacataattg tcagattttc caaggtcaaa 173520 atgaaagaaa gaatgttaaa ggaaactaga gagaaaggtc agtttaccta aaaagagaaa 173580 cccatcagcc taatagtaga tctataagct gaaactttgt aagccaaaag agattgggaa 173640 cctatgttaa acattctaaa aaaaaaaaaa aaaaaaaaat tcaaccagaa attttatatc 173700 cagctaaatt aagctttcta cgtgaaaaag aaataaggtc tttttcagat aagcaaatat 173760 tgaggaagtt cattacctcc agacctgcct taaaagagat cttgaaaggc ggaaaggagc 173820 actaaatata gaaaggaaag accactagca gctaacacaa aaccactgaa acacacagat 173880 cagtgtcact ataaagcaac cacacaaaca aaccaataca ataaccagct aacaacataa 173940 tgacacaatt aaacccacac acatcagtac taaccttgaa tttaaacaag ctaaattcct 174000 tcacttaaaa ggcacagagt gacaagctgt ataaaaaagc aagacccaat ggtatactgt 174060 cttcaagaga cccgtctcac atgcaatgac acccataggc tcaaaataaa gggatggaga 174120 aaaatctacc aagcaactgg aaaacagaaa aaaaagcagc agtgagaatc catatttcag 174180 acagaacaga tacagatttc aaaccaaaaa aaagcgggca ttacataatg gtaaagggtt 174240 caaatcaaga agaaaaccta actatcctaa atatacatac acccaacaca ggaacaccaa 174300 gattcataat gaagcaagtt cttagagatg tacaaagaga cataaacctc catacaacaa 174360 tagtgggaga ctttgacact ccactgacag tactaaatca tcaacataga aaattaacaa 174420 gatattcagg gcctaaactt agcactggat caaatggatc tgattgacat ctacagaact 174480 gcaccctaaa acaacagaat attcattctt ctcattgcca catggcacat actctaaaat 174540 tgaccacaca aacgaacaca aaacaatcct cagcaaatgc aaaataatca aaatcatacc 174600 aagcacattc ttggaccaca gcacaataaa aatagaagtc aatactaaga aatctctcaa 174660 aaccatgcaa ttacacgcaa attaaacaac attctcctga atgactttgc gtaaatattg 174720 aaatcaaggc agaaatcaag aaattctttg aaactaatag aacaagggta caacatgcta 174780 gaatttcggg gacacagtga aggtggtgtt aagagggaaa tttatagcac taagttccca 174840 catcaaaaag ttagaaaaat ctcagattaa caacctaaca ccataactga aagaattaca 174900 gaagcaagag caaatcatgc tagcagaaga caagaaataa ccaaaatcag aactgaactg 174960 aagaaaatca agacatgaaa aaccactcaa aagatcaaca aattcaggag ttagtttttg 175020 gaaaaaatta ataagataga taggctgcta gctagaagaa aaaaagaaga aaagagagaa 175080 gatgcaaaaa aaaatacaat tagaaataat gaagagaata ttaccactga tctcacagaa 175140 ataaaaataa ccatcagaaa ctactacgtg cacttctatg cacacaaact agaaaaccta 175200 gaggagatgg atgaatttct ggagacacac catcacaaga ctgaaccaga agaaattgat 175260 tcagagaaca gaccaataat gaactccaaa aataaatgag taataaatag cctaccaacc 175320 aaaaaaagaa aagtccagta tctgatggat tcatattcat agccaaattc taccagatat 175380 acaaagaaga gctgtatcat ttgcacagaa actattccaa aaatttgaag aggagggatt 175440 cctccctaac taattctatg aagccgatat cattctgata caaaacctgg cagagacaca 175500 agaaaaaaag aaaacttcag gccaatatgt tcaatgaaca ttgatgcaaa aattctcaac 175560 aaaagacctg caaaccaaat ccagcagcac atccaatagc taatccacta cgatcaagta 175620 ggcttcatca ccagaatgca aagttggttc aacatacaaa aatcaattaa tttgattcat 175680 catataaaca gaactaaaga caaaaaccac atgatatctc aatagatgca aaaaaggctt 175740 ttgataaaat tcaaaacttt ttcatattaa aaaccctcaa taaactagga attgaaggtg 175800 cattagtcag ggttctctag aggtacggaa ctaataggag aggagtatat atgaagggga 175860 gtttattaaa gagcattgac ttacactatc acaaggtgaa ggcctacaat aggctgtctg 175920 caagctgcaa gcaaggaagc cagtctgagt accaaatgta aaaggtaggg aagtcaacag 175980 tgctgccttc agtctgtgac ttaaggcctg agagcctctg gcaaatcact ggtgtaagtc 176040 catgggtcca aaagctgaag aacttggagt ttgatgttca acagcaggaa gcatccagca 176100 caggaccaag atgaaagcca ggagactcag caagtctagt cctttcacat tctttcacct 176160 gctttttttt ctagccatgc tggcatctca ttagatgata cccacccaaa ttgagggtag 176220 gtcttcctct accagtcccc tgactcaaaa tgttaatctc ctttgacaac gccttcacag 176280 acacacccag gaacaatact ttgaatcttt taatccaatc aagttgacat tcaatattaa 176340 ccatcacaga atgatatacc tcaaaatgat aagagccata tatgacaaac ccacagtcaa 176400 cattataata gattggcaaa tcctggaagc attccatcga aaaccagcac aagacaagta 176460 tgccttctct cactactcct attcaacata ttattgtaaa ttctagccag agcaatcagg 176520 caagagaaag aaataaagaa cattcaaata ggaagagaag aagtcaaact atctggttgc 176580 agatgacata attctatatc tagaaaacca catagtcttg gcccaaaagc tccttcagct 176640 gataaacaat ctcagcaaag tttcaagaag caaaatcaat ggacaaaaaa tcactagcat 176700 tcctatacac caacaacagc caagccaaga accaaattag aaaggcgatc tcattcacaa 176760 atgccaccga aagaataaaa tatctaggaa tagagctatc caagaagata aaatatctct 176820 acaataaaaa ttataaaaca ctgcccaaat aaatcagaga agatataaac aaatagaaac 176880 acatcccatg ctcatggata tgaagtaata atatcattaa aatggccata ctgccaaaag 176940 caatttacag attaaatgat attcctatca aactactgat gaaattcttc acagacttag 177000 aaaaaactat tttaaaatcc acagatccta aaaagagctc aaatagccaa gcaatcccga 177060 gcaaaaagaa aaaagctgga ggcataatgt tacccaaatt caatctatgc tataggggta 177120 cagtagccaa aacagcatga tactgctgtt acagaaacag gcacatagac taagggaaca 177180 gaatacagag cccccaaatt aaggccacac acctgtgacc atctgatctt tgacagagat 177240 gacaaaaaat aaggattggg gaaaagactc cctatttaat aaatggtgct gggataactg 177300 gctagccata tacagaagat tgaagctgaa ccccttcctt aaaccatatg caaaaatcga 177360 ctcaaggtgg attaaagacc tcaatgtaaa actccaaact gtaaaaatcc taaaagacaa 177420 cctagccaac accatcatgg acacagaaat gggcaaagat ttcatgacaa ggacaccaaa 177480 agcaattgca acaaaagcag aaattgacaa atgagatcga attaagctta agaacttctg 177540 cacagcaaaa gaaactatca acaatataaa cagatagtct acagaatggg aaaaatattt 177600 gcaaactatg catctgacaa aggtctaata cccagaatct ataatgtaca taaacaaatt 177660 tacaaaagaa aaaaacacat taaaaagtga gcaaaggaca tgaacagaca cttttcaaaa 177720 gaagacatac atgcagccag caaacaggaa aatttcagta ttactgattg ttagagaaat 177780 gcaaatcaaa accacaatga gatgccatct cacaccattc agaatggtga ttattaaaaa 177840 gtcaaaaaca agagattctg gcgaggttgc agagaaaaag gcacactttt acactgttgg 177900 tggaagtata aattagttca acagttgcgg aaagcagtgt ggtaattcct aaaataccta 177960 aaaacagaaa tacttttcga cccagcaatc ccattacagg gtatataccc aaaggaacat 178020 aagtttttct atgttcctac ccatatatga ctgtgggttt gtcatatatg gctcttatca 178080 ttttgaggta tatcattctg tgatggttaa tattgaatgt caaattgatt ggattaaaag 178140 attcaaagta ttgttcctgg gtgtgtctgt gaaggcgttg tcaaaggaga ttaacatttt 178200 gagtcagggg actggtagag gaaacatgca cacatatgtt tattgcaaca ctattcacaa 178260 tagcaaggac atggaatcaa cctaaatgcc catcaatggt agagtgaatt ttaaaaatgc 178320 ggtgcatgtg catgatggaa tactatgcag acataaaaaa caataagatt atgtctttta 178380 cattgttgat ggaagtgtaa attagttcga ttgtggaaag cagcatggat tcctaaaaga 178440 gctaaagtac agaacaacca tttgacccag caatcccatt actggaaata tactcagaag 178500 catataaatt attctattgt aaagaacacg cgtgcaaatg ttcattgcag cactattcag 178560 gagagcaaag atatgaaatc aacctatgcc catcaatgac agattggata aagaaaatgt 178620 ggtacatata cactatagaa cagtagacag ccataaaaaa caagatcatg tcttttgcag 178680 gaacatggaa ggagctgaag gcctattctt agcaatctaa tgcaagaaca gaaaaccaaa 178740 taccacatta tcacttacaa gtgggagcta aattataaaa tcctatgaac ccaaaaatga 178800 aacaacagac agtagggtct tcttgagggt ggcggctagg aggctagaga ggagcagcaa 178860 aggtaagtat tgggtactgg gcttaatacc tggatgatta aataatctgt aaaacaaatg 178920 cctgtaacat gagtttacct ccataacaaa gcttcacatg taccccgaac caaaaataaa 178980 agtttttaaa aaagaataac tcatttgtgg tctaattata tcttcaaaat cccttcacaa 179040 caacacctag attagtgttt gactgaataa ctgggagaag gtgtgtgtat agcaagtgct 179100 gggaattacg gggtctatct tagaattttg ctagcacacc ttctgagtca aaggtgggtt 179160 cccattagag tagaaatcag cactgcttct gaaatttccc cgaattgaaa ctatgggcga 179220 actatacaag aaagatcttg gaggacttac ttttacccta tcgttcacta aatgtttatt 179280 gtccacatta tatttgctga gcacgattct attcatgaaa gacatggtgc tgaataaggt 179340 gatcacattc aagaaattca gagagtttag tctttagtga ataagaggag tgtaggaata 179400 tagagtctaa tagagtacat gttttaaagt tacttacaaa tttatctcaa ttatatatat 179460 atgtgtgtat acatataatt gagtatatat atatatatat atatatatat atatatatat 179520 atatactcag tgataagtgc tatgaaggga aacctgcgta cagaaaatga tgatgtagtg 179580 ggaagtattt taaatgagct attgacagaa ggcctctctg aggaagtaat atcagagcct 179640 aaacctttaa gaagtgaagg agtaaaccag aaattgcttc cagtacctct gtaaaagccc 179700 aaagctgtaa taagctcagg cttcataaag ataacaagga ggctgatgca gatacaatta 179760 aaatgagtga aagatgagta gtgtaaaatg aggtaggaag aaggagacta aagccagata 179820 atgtaaaaac ctgctactaa tagacgtcag tcattgtcca agcaaaataa aggtattttc 179880 aacattcaaa aataacaaga gatcatggtc gctaacaaag aggctgatgc agacagaatt 179940 aaattgaatg aaagatgagt agcgtaaaat gaggtaggag aaggagatca tggcagatgg 180000 gaggcaggat agatcgcagc tccaactcgg atggacagag caatgggcag aggcctacat 180060 cgtgaatttt agctccgaga ttgattgcaa gaatgaacca gaaatccaga gaggacccac 180120 agaccctctg aaggaagggg acttctcttg cagcacccag gagacaccca aatactgtga 180180 gtgtcccagc tgcagaagtg gggaaatgag atcctcctct cccaaacaca cacccccact 180240 ggggaaactg aaggtttgct tgttggagaa gtttctgacc ttaactggag ctgagtcaat 180300 ctagagagtc cagtgaaata caggggaaaa agaagcagca ggaaaggccc tgggagctca 180360 ctgggttccc aggcagtcca ttcctgcctg gcaccacagg gatccttggg agggtggcca 180420 gaggggcaga ggaaaatgcc acaggaagaa ggaagtctct ggctaaattt tgaaacagtt 180480 ctagctaggc aagaggcctc ttggccagaa ttccagggag ggtgtaaatc tggtgtgcag 180540 actctatagg caggggaaga accaagacct tttctttcac agctgggagg tgggtggcct 180600 ggggcaagtt ctcaagccct gctctccaac tgcctggaaa cagatttggg gctgttcaga 180660 tgtgtatggt gggagtaaga ccgtcccttc aggttgcgtg ggagctgggt aaggcctgtg 180720 actgctggct ttcccccact tccctgacaa cctgcatgac tcagcagaga cagccataat 180780 cctcctaggt acataactct attaacctgg gaatatcacc cccatcctcc acagcagcca 180840 cagcaagacc tgcccaagga gagtctgagc tcaggcacgc ctagccacac cctcagccgc 180900 acccccgcct gatggtcctt ccccaaccac cctggtagag gaggacaaag ggcatagtct 180960 tgggagttct agggccttgc ccactgctgg ttcctctcca tactaccaca gctgatgctc 181020 cctggaaaga accacctcct ggtaggaggt caaccagcac aaaaatagag cattaaatca 181080 ccaaagctaa gaaccctcac agagtccatt tcacccccct ggcacctcca gtggaacagg 181140 tgctggtatc catggctaag agacccatag atggttcaca ttacagggct ctgtgcagac 181200 aacccccagt accagttcgg agctgggtag acttgctgaa tggctagacc caaaagagag 181260 ataacaatca ccggagctca gctcacagaa agtgacagta ataggaaaat ggggagagta 181320 caacatcaag agaacaccct gtgggacaaa agaatctgaa caacagcctc cagccctaga 181380 ccttccctct gacacaggct acccgaatga gaaggaacca gaaaactaac tctagtaata 181440 tgacaaaaca aggcttttta acacccttca aaaattatac tagttcacca gcaatggatc 181500 caaaccaaga agaaatccct gatttacctg aaaaagaatt caggaggata gtcattaggc 181560 taatcaggga ggcaccagag aaaggctaag cccaatgcaa ggaaatccaa aaactgatac 181620 aagaagtgaa gggagaaata ctgaaggaaa tagataacat aaagaaaaaa aatcaaaact 181680 tcaggaaaca ttagacacat ttatggaatt gcaaaatgct ggaaagtctc aacaatagaa 181740 ctgaacaagt agaagaaaga aattcagagc ttaaagacaa gatcttcaaa ttaacccaat 181800 gcaacaaaga caaagagaaa agaataagaa aatatgaaca aagcctccaa gaagtctagg 181860 attatgttaa atgaccaatc ttaagaataa ttgatcttcc tgaagaagaa gagaattcct 181920 aaagcttgga aaacacattt aggggaataa ttgagtaaaa cttccccagc cttgctagag 181980 acctagacat ccaaacacaa gaagcacaaa gaacgtgttg gaaattcatt gcaaaaagat 182040 cattgcctag gcacattgtc atcagattat ctaaaggctt tacatgcata tggacaccaa 182100 aagcaagcag gggtagctat tcttatatca gacaaaacaa actttaaagc aacagcagtt 182160 aaagagacaa agagggacat tatacagtgg caaaaggcct tgtccaacag gaagatatca 182220 caatcctaaa cacatatgca cctaactctg gagctcccaa atttataaaa caattactaa 182280 cggacaagaa atgagataga cagcaacaca ataatagtgg ggtacttcaa tactccactg 182340 acagcactag acatgtcatc aagacagaaa gtcaacaaag aaacaatgga tttaaactat 182400 accttggaat aaatgaactt aacagataga tacagaatat ttcatccaac aaccacagac 182460 tacacattct attcaacagc acatggaact ttctttaaga tagactattg ataggccata 182520 aaacaagcct caatgaattt aagaaaattg aaattatttc aagcactctc tcagaccaca 182580 gtggaataaa actgaaaatc aactctaaaa ggaaccttca aaaccatgca aatatgggga 182640 aataaataac ctgctactga aagaacgttg ggtcaaaaac aaagtcacga tgaaaattaa 182700 aaaaattctt caaactgaac aaaaatagtg acacagccaa tcaaaatctc tgggatacag 182760 caagggtggt gctacgagga aagttcatag ccctaaacgc ctacatcaaa aagactgaaa 182820 gagcacaaac tgacattcca aggtcacacc tcaaggaatt agagaaacaa gaacaaacca 182880 aatcaaaact cagcagaaga aaggaaataa acaagatcag agcagaacta aatgaaattg 182940 aaatagaaaa ccactactaa aaaaaaaaaa aaaaagaaaa gaaacaaaaa gctggttctt 183000 ttaaaagatg aataaaattg gaaggacatt accaagatta accaagaaaa gaagagagac 183060 aacccaaata acctcattaa gaaacaaaat gagagatatt acaagggagt gacaccactg 183120 aaatactatg aacataaact agaagagatg agtaaattcc tagaaagaca caacccacct 183180 agtttaaatc aggaacaatt agatatcctg aacagaccaa taacaagcat tgagattaga 183240 atggtaatta aaaaattatg gtaaataaaa aattaccaac aaaagaagtc caggaccaga 183300 aggattcaca gcagaattct agcagacatt caaagaaaaa ttggtaccaa tatttttgaa 183360 actattccac aaggtagaga aagaaggaac cctcgctaat tcattccatg aagccaacat 183420 taccccaata ccaaaaccag gaaatgacat aaccaaaaag gaaaactaca gaccgatatc 183480 cttgatgaac gtagatgtta aaatccttaa ccaaatacta gctaaccaaa tccaacaaca 183540 tatcaaaaag ataataggtt tcataggtaa aagccctatt tatatttagg gtaaagaggg 183600 acacggagac tatgacatcc cttcccagtg taagagttgc agtaacaaag tgtttctcag 183660 tggaggataa ttcttctcag cagaacattg tcagcttctg gagggccagt ggcatggcag 183720 cagggctaag aagctggagt gaaagcacta gatactctac ttcctgagca gtggtagact 183780 attccctcca gaatttcaga aaaaacaaaa aatagggaca ctttgaggag aaagctaatt 183840 tctgataaca gcatcataga cttacactga cgtagttgag ttacaaatgt aaaatgattg 183900 gcaaaatgtt tagcacacag gatgcaacat gtggtacttt ccttccctct cttttacagt 183960 gaaattttca tctaaataag taagtaaata gattagtggt ctccactttg gctcctgtgt 184020 tcagctacaa tttctattta gaataggtag acacttttat ctgattggtg taataacttg 184080 gctaaagctg tggtgtgttg gtcatgcaga atagattatc caggatgccg aaggaatgga 184140 gctttgtatt tggggctttg ctgactgcct gattattcta cagaccaatg aagagtctct 184200 gcatccacag ctattacact gcctcctgaa gaggaggcca aatatcttat aaattacaag 184260 attcaaaata ttattcaaaa taatcccact tgtcttcaaa tacacatttc ctccaaaaat 184320 taaaacacac agaaagaaaa tgcaaaactc cacaaaattt aagaaacact ccaggccatt 184380 atttcaactt cgccgtgaac aattcaggga aatgacaacc caggtggtat tttccatttg 184440 actaacttat gttttagtac ttggcacttg tgtgtctact cccataacaa gcaactatgt 184500 ggtgattaaa aattaaatgt tttgccttgt ttgaagagct gctgttcaga gtattgcatt 184560 ggaaagcact tacctgaaag gagagcttat gttcggttag tggtggagag cagagtgatt 184620 tccatttgct ctgtgcatgt cactggagag gttctaaact gtaaatgctc actgtccatt 184680 tatggggttt atgtatgcaa tttctgcaga aatcgtcttt gtaaatggga atgaaaatta 184740 tccttgcact tattccacag ccttttctca tctccagcaa gtgaaaatga gcctttgggt 184800 ctcaaaatat ctcctgtgtg tttgattttg ttgggcagat ttgaaatgat cctccagctc 184860 caaagttggt aaaaacagaa tggttttctt cttattaact gagcaactga tatccttaaa 184920 aatgatgtct gtatatttct tattatatga cacaaattcc agggaaagac cacgggaatt 184980 gtagtcaggc ataacaacct tttttctctc tctgctgttt actggctgga taatacaggg 185040 taaattattt aaattctctg aacctaaatt ttctcatata taaagtgaaa ttgaaaatat 185100 ttttcccaaa tttctgcttc cagaaaatgt ggtccactaa cctaaaactt gagagcatgg 185160 tagtgtatat aaaacaaaat tctaagcctg acaaccaact gattggaccc tttctctcag 185220 tcaagagcgt tccaaaatta acctgaaaaa tcagttaatg tcataatgtg aagggggaat 185280 cagacacgcc ttatactctc catcctttgg aattcaagca cagctgacca gtatcagcat 185340 taaaacagag atcttaagac taacaaaaca gactatttgt agcaataaga tacacaattc 185400 caaccgaact ctagtatagc atcatacgac agatagcagg ccctgaaaga aatcaaagta 185460 tttcacccca aaatatatct tactaagtct tttcaggaaa gtcaggcacc ttttaaggtc 185520 tgataaaaag acatttacca tttaccatcc attgtctctg aagtcttctc cctagaggct 185580 tcacctgtat aacaagagcc ttggtttcca caaccctcct tatcttaacc ctaagcattt 185640 ctttctgatg acttcaactc ttcaaacaaa acttaactct ttcaaccaac tgccaattgg 185700 gaaaactttg aatccaccta tgacttggaa gccaacctgc ctcctttaag atgtgtcacc 185760 tttctaaacc aaaccaatgt acacattaca tgtattgatt gatgtctgcc tgtaacttct 185820 gccccccatc ccttaatgta caaaatcaat ctgtgacctt acttccttga gcacatgttc 185880 tcaggacctc ctgaggctat ggtgtgggca tttcctcaac tttagcaaaa taaactttca 185940 aaattgatgg acacttgcct gagatacatt tttgtttaaa gcacaaagag gagatagaaa 186000 aagagagatg agagtaatga atgtaaaatc tggaagaaaa tattgtggag acagaaaatg 186060 attgagtccc attgagggga aagcatctgt cttgagcaaa aaagatcctg acagatggtc 186120 agagaatatg ttgggagaca cttttcattg tgactttttt ctccccaaaa ttttccataa 186180 taagccattt ctcatccctt gacccaacat ggttggtctc tggaacagga gcactgttca 186240 catgctgctc aagaatggtg gtggtaacag cagagcagct cttgagactg gttggtggaa 186300 aataagtatc aatgagggta tgcaggacag ctcatctcta aaaattactt tgcctgcata 186360 aaacataact ccaagagcta gaggattact ctttggttct ggtttttatg gcagcttcat 186420 tacgtagcca tgattgatta agtgattggc cactggtaat caacttaatt tccagcctct 186480 ttctcctttc ctgaggttgg agggtggggc tgaaagtacc aactcactaa tcacacggtt 186540 cccctggcca ccagcccctt catccttaga gattttccaa acgtcacctt attaacataa 186600 actcaagtgt aatagaattg ggcttgttat gaataataaa agaccctcct ttaaacttta 186660 taattttgaa gctatttcag gaatgggaga aaaaacaatt attctttgaa aaaaggtatt 186720 cctcttattc ctataactca ggaatttgca agagttttac aagttctgtg atgggaacca 186780 gggacaaaga ccaaatatct gtttcttata tcacaagttt tcaaaaacca attaatacat 186840 tatttattca tttattcatg tatagataga tggttactgt caaaaataaa cactttgtgt 186900 ttataggtaa tgcagcaatt acaatatata gggcacgaat gaagcttcac aggtgtcaag 186960 actcgaaatc ttatagacta agttctttgg ccagaatgca atacaattgg aaatcagtga 187020 taaaagagcc acttcaaatt tttattttag acaattaagt aagaaatcaa agagattttg 187080 aaaagtatta gaatattatg agctgttata tgatactata tttgaaaact tagctgaaat 187140 ggtaaattcc tatagaaaca tgaaatttca aaaatcgttg ataaagtaaa gagcataaaa 187200 cattcagtat gtgttaaagt aatggaaatg gtcatcagaa gagcaacaaa taagttctac 187260 aaactttcac agaatagcta tttattaact tacaaaagtt gttccaggac aaaaaaataa 187320 agctttccca gctcatttta tgaagcaagg gtaatcttta ttccaatata cataaggttt 187380 ctaaaaagcc attcttgagg gtgtgtggcc aatatgctgc ttgttcaaga ttaactgagg 187440 gattagcaaa gaaagctcag aaatataatc atgtatttgt agcagatatg ctaagtgaca 187500 gaactggaat gcccagttag tagggaatat gtaaaggata aaggccacta aatggagaaa 187560 agttacgttc aatttctttc attcaatata taaatgttaa ctccagagtg cttaaaaacc 187620 ttaaacacta tcaagctaaa gtaagaaaat gtagaatatc attgagccct ggcgtaagga 187680 tgggggaaag agatagtata ccagattctc aaacaaaaga ctataaaaaa agagttaatg 187740 gattgtatta cggaaatatt aaatatttca ttaaagaagg aaagtatagg tgatgttagc 187800 aaacataggg cagattgaaa tgagggattt gcagcaacta aaaccaatta aaagccaatc 187860 tgttaaatat ggaagaaatt ctacaaatcc ataagaagaa cacaaggaaa tacagagaac 187920 aaacctaaat atctagaatt atatgaaaag atactcatcc tcaccaatag aaaactgcga 187980 tattgcctta tacatattag gagatgcatc ttaggaaaaa atagagcttt gaattatacc 188040 aagcattgtt atggatggag tggtgtgtgt ggcagtgacc agaatggatg caaactgata 188100 aggttgatct ggagagcagc tgacagaagt tacattgcat atgtgtacac cctgttacca 188160 acaagcccat tcctaggttt atattcccaa gaagttaatg aaaaatcatg tgtgaagctc 188220 attcttttta tcactgtttg tgatagctac tggttgtagc tatctctaca tttatgtatc 188280 tctaaataca taaaatatga ttgatgtatt cagtgtggca agcacttagg agcagtcaat 188340 taggtgtacc tgtgaccaca tgaagattac ttaatgctac cacgttacac gcacatacaa 188400 ataggctcca tggcacaatg tcatttacat atactaaaac acatacaaaa acccaacact 188460 ctttttataa ggttatatac aaatccaaag acatgtaaca aacacattag attgggtgtc 188520 tgtgttggaa catagaacag gattgggggt caggaaaagc aaaaagaaaa taaaagagaa 188580 tgaggtcttc catgaactaa tgataattat gtgccataaa ctggaagtta tacttaatta 188640 aactctatag ctgagaccaa atagaaagaa aaaagtgtgc agcagcaagg aaatgtttaa 188700 gttaacaatg ctcaacatat ttgtgcatct ctgcagttta gaaaattgaa attttgaagg 188760 gattggttaa taccatattc atttgctttt tgtttggtta ctttttatct cagttcctcc 188820 ttaaggagaa gagcttaatc cttgctgtga atttcttttg tattatttgg gcaaaatctt 188880 caagtgtctt aataaatata tgatctttct ttagtaccgg atgggtggga ggtttttttc 188940 tctttctcat attcagctcc atgttctttc cagcagatgc tgctatcaga gcgtgatcct 189000 cagttttcat aaaaatgcac acacttacaa caaaaattga ccacactttg gcagcttatg 189060 tattaagtgt tcctaccaca ctgcgatgta tcagtgggca aacactgcat taaatgagct 189120 atagcaaagc aatccagaag agaactatgt ggtcattaga atgatggaaa taactttaac 189180 aagacggtga ctgcaacaat atgagtggaa acaatgccca aacaacaata ttccacgtat 189240 agtatttata gtaaaaatac gtttgaaaga aaatatgaaa cacgttggta atgatttttc 189300 actgtggtga gaagattggt cctggctgta acagaaacca tcagtaccat catccccaca 189360 gccctccaac ccttccctgt gcttcgcagt ttccagctgc cagggtcggc atctttgtgc 189420 ctgagggctt tggaaagcct ctctgctgat gtgcccatac accaaggaat tgacacctcc 189480 tgggggcagc cctcaacaga gacccatggg agttcatgta taacaccaac agaaaaacaa 189540 tgcaacataa aaaattgtgc tgtgacaaat taatgattcc catcagtgtg actgacagag 189600 tttaaaaatg tttacaatat gactttctga cttcctcagg tggtgtcaat tcctaagaca 189660 aacaccttgt aattcattac aaatgcaaat atgtcaaaca ttgttctttg aaaataaata 189720 aataaaaatt gatatggtat taaaatactg ctgtttttcc tgtctgatac ataaagaaaa 189780 tgtaatgtga atacttatag tttccaagag tatgtggaaa ttgacattca catatacttt 189840 ggtacgtaag taaatttata gcaaaataat ttaaaatatg aacaactatt ggtatgttta 189900 ttgtggcatt atttgtaata tcaaattaga aacaaagtaa atgtccaaca actaaggttt 189960 taaaaaatgt gttacagttg cacaacaatg tacttaatgc cattgagctg tgcacttaaa 190020 aatcgttaaa atggtaaatt ttgttaggta tattttatca caataaaaca tgtattatag 190080 tgcacctaac aaagaaatga gttattaaag atgatatcgc aaagcatttt atcaatggag 190140 aaatgtattt ctatgtgtgt gaatcatgct ataaaaatgt gcttaatatt tacattgtat 190200 attatttatg ttatatatat gtaaatgcat atccatttat atttatagac attgaaaaag 190260 gttacatttt aacatacact tcatgtaatt atagttcttc acacattttt cttttgctta 190320 tttaattttt ttcaatattt ctctaataag ccaatcttac ttaagttaaa tgaaaatgac 190380 cctgtgatct caacactttg ggaggccaag gtgggtgaat cacttgagtc caggagtttg 190440 agaccagctt gggcaacatg gcgaaacccc acctctacga aaaataaaaa aaattagctg 190500 agtgtggtgg tccaagtctg agctactgag gaggctgaag taggaggatt gcttgagcct 190560 aggaggtaga ggttgaacaa tgagccaaga tgatggcact gcactccagc ctgagtgaaa 190620 gagacaggcc ctggtttatt gatttttttt tttttttaag aaaatgacct tgatgtggaa 190680 acatttggaa taacttcaca aatatgttct tgggtgtcta atccaaaccc gagaatcaat 190740 aatgcttata aaatgggaga aatagggcga aaatttattt ttcttaaatt tttctttctc 190800 atttctctga ttcaaacttt ttgacctact tttttttatg aataagaagc aattgattta 190860 aaatacctta attttatctc atttcttaat tacaaggaaa acataggctg atttgtccat 190920 ttttatttaa agtcattctc agaaggcttt ctgtgcttca catttaagtc actttttacc 190980 tgataatatt atttatgact atgttttctt ctattgggtt gtaagtttta tgaaaactgc 191040 attctggcta atttatttaa tgtatttccc acagtgtcca actaaatgtg tgtttgtaca 191100 taatagattc ttagtatatt tgagggataa caaatggcag taaattaacc ttttcttttt 191160 ctaccgtttt tttccatttt tttaaaaaaa catatggggc cttaatgggt tcctcccttg 191220 tgtgtttctg ttcctttcac tcaagctccc tcctctcctc tattagaacc attttcaggt 191280 atttttcctc tcttagggaa catgtaacat tcaatggtta agatttatgg aaatgtgccc 191340 cccaatatgg ctacatgccc attttgtatg gtgtgaagac cataatttta taagctagcc 191400 attccattat tggactgcca aagctattaa tatgttcttt ctaacacgtg agctgcattt 191460 ttttccccca tgaatctagc cattgaatcc agctctgccc ctactgaaac ggggaaaggg 191520 tatggtctct catctacatg gcactctatg gttgaagagc atgacctggg ttcctcagag 191580 gctcctttac tgggctaggt ggccctgggt tctcacatag cccagttttc tggaccttgc 191640 actgtgatgg ctgttcatga ccacactgtt ggttagccat ggtgctccca agacagggca 191700 cagtgctcct gatttaacta gccgcaaaca gaagacaggg gggctttgcc attttagaga 191760 ttataatcct atcataatca tctaagtgct ttggctttat ttcagcaagt gtggccattg 191820 ctctgttatg cagatcttat gcctctttgt cctgtttctt gatgtccatt tatattctga 191880 gtgtgtgttc tccagccctg caagcttgtg ctgctgactt cataggtaag aattccatat 191940 tttgtttttt taacccattt gttttcaccc aggttatgct ttataaacat taattgataa 192000 taaaacttga aagttaattt tctctctcta cgaatttccc ccaccctagc actcctgaat 192060 cattgtggca tcagaacaga gctggcatgg tttctatggc acagaaaaca ctgtgggaaa 192120 agggtctatg caagacttcg ggatggacac tgcagaagtt agggaaccaa aagaccacat 192180 gttaaaactt gctcacaaaa tatcaccact tggcagtcag agagaagggc caatgccagt 192240 ctgaggcacc gacttgaggt atagctttat gttagcacaa aattaatgct gattaacttt 192300 atattataat taattcttca gtacattatc tactctaatc ttctcaacca cttagtaaga 192360 aaattttgtt tattttccct attctacatt tcaggaaaat aagtattgga aaactacgta 192420 cttccccaaa ggatactctc aagttttggc aaaaaagacg tctttcttct ttgccccatt 192480 gtcctgtctc tgtccttagg gaaagaaaca tgaagaaatg ctccctggcc ttttaactgt 192540 tcttgtggtc acagctccca aagagagtaa ggactcctaa tctgtgtgga cagagcctaa 192600 atttctgggt gatgtttcac taggctgcag aaaaagcagg tgcccaacct ccacgttcac 192660 ttcctgcgtg tgtctctccc caggcttctt gcagttttgg gctccatgag aaaagccaga 192720 atgggggccc catctgtgca gagtgcagcc aaatgggcac tctctgctcc agattccaga 192780 cctgctggga caaggtctct gactaacatg tccactggcc gtttgtctag gaaacagttt 192840 gtgtatctac taggttggtg caaaagtaac tgcagttttt gccatttaaa gtaatggcaa 192900 aaccattatg tagtaatggc attactttaa atggcaaaaa ccgcaatcac ttttgcacca 192960 acttatagct cttctagatt caagggtgac aagtagaatg ctttacattg attcctgaac 193020 cttagccttg agtactgatg ggaagagatc tgctccagat ggccatggtg ttgtaatcaa 193080 ggtctggccc aagtactaag agaaagtagg gttttgtttt tgtttttgtt tttgtttttg 193140 tttgtatttt ccagtttctc tttggctgtt gtgctcatgt ccaggcatag gtaatgtctg 193200 agcgagtaca atttcctctc tgtaaaactg taaaggagtg agtagtaggt ttcttgtccc 193260 aaagccactg ccttatattc ttaacattaa ccttatactc caggtgccag cctgtcccag 193320 gtatagaggc atggggctta gttgattcat gcaggaagaa atcctaggta gtttcttgga 193380 aatcttctta gctttaatta atccagggaa aatctccatg gatactaagg acttttctta 193440 tcctctgtct taggacacac atgtgtggct taagttctgt ctagtttccc ctactgggga 193500 tttttttttc aactatcata ggcattaagt cggaaaggac ccctgataca catactgatt 193560 aataagagaa taacagacat tcattagcat attatttcat atatatggga gacacccaga 193620 gaatgagtag ttctcaaaga ggtggctttg aatgtcagct tatagagcat cttcgacaaa 193680 gtgttctttg ttggtgagga gtaaatttat agagaagtga caagaaaaag gaaagggacc 193740 tggagtttcc agccagggta acttgtggga aggcaaataa ctgatagata aagtctggtt 193800 agcaaatgtt gtcaacaaag attcctctcc agatggtaag aatctaaagc tgtcttcagt 193860 agttaacctt tgttctcccc aagggaggtc aggataccct ttacctttgt aaatctgtgt 193920 cttgttttta ggcaaacaca gggagggcag agagtttctt gtatctgctt caacttgcct 193980 tcagctcaac ccttcatatt tcagggaggt atattcggct gcccctctgc catactccag 194040 cattcctctg cttttctctc caatgtactg cgcctttctt ttccatccta tcctcacatt 194100 ttgatgtagt gtgtgttgcc ccaggccagg tagcagaaac atcccctgtg caatctctcc 194160 ttactctcgt caagctacac aagcttccct ctgtgaaatg accctctcct cctgcatttt 194220 atttcatgtt gcactttctg ctgggcagaa accaattttg agcctgctcc tgagagctgg 194280 gtgaagccct ccctaacact atgggtgcat cccagttcca tgggtgccca tgagcttgtg 194340 atactgtatt ctgtttattg gtttacctct gtctctacag cattacacta ggagtttctt 194400 aattattcca ccctttattc attcaatata tattgtgttg agcatgcccc atgtgctaag 194460 agccatggca aggtcccaga gtaaaaagga tcaaaacaaa caaaagaata aaacatggtt 194520 actgccctca agtaattcac aatgtaatgg aaaatccaga ttagtggaca cacacactgc 194580 ggcgatggtt caagagtcag ctaatgtctg tgaatccctg gaagagatgc ggtttatctg 194640 gatgagaagt gaggagactc agactctagc agatcacttt acctggtgcc ctgaaaggtt 194700 agcagttact ctccagaggc agcaggccag ggatagaaag gggtgggggg taggaacagg 194760 aaccacgcac acactgagga atgaggctga aatagcagtg caatgtcttt gtggctggtc 194820 aaagcacagg aaattggaag caattcagtg tggtgggaga agagagtatg gggggagggg 194880 ctgggagttg aggacatgtg gattggagac agaggctcaa ttcagctatt cgtctttgca 194940 tctactctat cactccacaa ggcataggct ctcttttctc agtctctctc tctctctttt 195000 tctctttctc tcagccgtta ttttctaatg agcaaatgaa tgaagaatga agtagacatt 195060 ccaaggctgc ctccaaatgc ctcttagtaa cataaatatg tatggatgat ggctgttgaa 195120 atcaccagga aaaaatatga acattactgt ttaagtctca ttattcctta agtgcctgtg 195180 tgtgtttgct taattacttt gaatggaagc atattttaac attgctatga catctcctac 195240 ggaataaatg agctaagaaa gagacttaag ctgtagacca caaatggccc ttatatcatg 195300 tgaagttatt aatacctgcc cttgttcatt gattatttaa gtaatttatt tccatttggg 195360 acattttacc tcaggtattc tagtctgtgc taaaagctgc aggaaagtgc acctgtccgg 195420 cctgcttggt gtgatgcacc gttcttgcac atatctgtcc caagctctgg ggtcactggc 195480 acccattagg ttctagaaaa actgtaggaa ggagcccagt gagcctggga ataggccagt 195540 ggggaagtac gaagaatgag aagcacaggg gagaattagg gacgcactgg agagtttctg 195600 ccactgaatt ggacaaaata tttgagttgt gtcagaaaat caaaattgaa caaaaaattt 195660 tgagaggcac ttactctgtt tttacccctg ggctaaacaa agacatgttt agatataaga 195720 atatattata ggtagataga tagacagtcc ctggcattgt ggaacttagg gtttacttaa 195780 agataattac ttcaggcagt attggaaatc atagtggtca atgaagatag tagatcttta 195840 ctatgtgttt tatcaaactg ctcttattca ttcatttcat aacatcgtaa tagctctcac 195900 ggaaaacaaa tttagtggga ataaaattgt tagatagtta ggcagacatg agcagggcag 195960 gagaggtgcc ttccaaccca ggaatgtcaa gtgaccatca ggtgatggtc aggcagttgt 196020 taaactgtct ctctaaaata aaaattggtc acagccagtg ctaaggaaag tctgtctccc 196080 aaaagataga aagtacttga agttggtgat ctgctgcttc ctgataagat ctcaggagtt 196140 gggcaagtgt gttcagacat gtgcactaag aggcaaaatg gcagtttaac tggtatatga 196200 ccttcctcta ggaacacttg gctggtaaag gaagaacgcc tcaagtgagc atgcccacaa 196260 catcagtaaa ccactgggca tgcggcccct cccacatgct ggcaggccac tgaacatgag 196320 gatagcccct cccaaggaaa aatcaaggga ggagaaatgc aaacactgga accaagccaa 196380 tgtgtaaaac cacaagtcaa gggccaaaca gcacacttag atctcttaaa tgtccacttg 196440 gcccccttcc aagtatactt cctttcgttc ctgtctaaaa cttgcctcag tctctctctc 196500 tgccctatgc ctctcacctg aaatctttcc tccaaggagg gaagaatcaa gttgctgcag 196560 atccgccaga tttgctgctg ctaacacaat gaactttgtg aagatgaggg aggaaagaga 196620 tttgagaact atgctctgat tttttttatc ttgcccaaat tcctatttaa gggtcctagg 196680 ggggtcatgc cctacaaatc ttaagttctc atcctatggg ttttatttaa ctctatatat 196740 tttgacttac tttccaacct gactctggcc ataaattaca agacaaggaa gaaaaataaa 196800 aatattttac catgaaacat atttctttgc catattttga aatggccctg caaagctgtt 196860 ctttgtggag gaaaatgttt catctgtaaa gaatctctat taacatagct agatcttttt 196920 ctttcagatg cttccaatcc taaagaaacc tctttaagat taactaagat ttgaatagga 196980 aacaatttgc catctattgt ctctaaaggc agccacaata agacttcaaa aaactttggc 197040 ctccacagtc ttttatctta ccctgaacat tccctttcta aggatcccag gtctttagac 197100 aaactcaacc aattgtcaac cagaaaatgt ttgaattcac ctatagctga gaagcctccc 197160 ccaactcccc tacccagttt tgagttgtcc tgcctttcta gaacaaacaa atgtattttt 197220 taaggtattt gatttatatc tcatgccttt ctaaaatgta taaaccaagc tgcgccccga 197280 caaccttgga cacatgttct caggacctcc tgagggctgt gtcacggacc atggtcactc 197340 atattttgct cagaataaat ctcttcaaat attttacaga gttcgactct ttttgttgac 197400 agaataacct gaagaattgg accacactta atgagaagcc gaatgtttgg aaagattatc 197460 gatttgtagt tgacgtttgt ttaattctag ggcagtatcc cacataaaat agagagaagg 197520 ataattttca tgattatcct taagcttaat aagatcacac atgcaaagtg ataggaaaat 197580 tgttgttgtt atttcaatca atgtagctat tatacttatg tcactcaata gagagaaact 197640 gcatgcttat gaaaggtcat atagtagctc atgggaagaa cttgagctga aacccagttc 197700 ctctgactca tattcaaatt atctttctag gaaatcacac aatatactca gttctcttta 197760 aaaacaccag agtccccatc ttgtgctcag aatgttctct tacactccct ttgcttcctc 197820 ttttctacta ggtgaaataa cagcatcact ggacgcaaga aggaaaccct taccccaacc 197880 ccactgaaat gatttagatg tccaggtaaa gtgtggcctc cctaaaacgt gtttcccaag 197940 ggtgactgaa atagcaccat tgaaaattca gcactctggt ttcagtgttg actttttcct 198000 ctcttttcaa agttgtcttt tgctgtgaaa cataaatgct ggtcacttca tcaacacttt 198060 atcataaaga ttattgaatt cattcaagtg actgagccct taggaatcct tcctgccttc 198120 agggaacact ctgacatttg gataaatgtc tcacattaaa gtaagtaaat aaaccagaca 198180 ccatttcaca ctagatccta gtgagaaaaa gaaagattcc aatcaaaggg acaaaatgga 198240 aatgacctct cccaactttt catatgtgta gattcagctg gggtaatcga aacaatggtt 198300 ttatcatcat gttccttcct tccagttcag gcctgatagg aatatctaaa gacctctgtg 198360 gaatcatagt aaaatgggca gatattggag catggtagta attattgatt gagaaaatat 198420 caatggcaaa tattacttta ataaccaggt tagtgagtca atccttgggt tgagaccata 198480 aacccaaatt catctttgtt taaattatag tatggcatat ttgtatcatg ttggaaaagt 198540 catttacttt ggtataatac acagatatat ttggtctttg ttctgaattc ctggcaccca 198600 gttcctagaa cgcttggaat ttcctgagtg atagaaatat cttttgttat tcataaggaa 198660 gctgtttcca tcacacctga gtttatgctg atatgtgact tcaggtggag cctttagata 198720 gcctcaggat gggagtggtc atcagaaaga ccaagtattt aggagactgg aacttctagc 198780 cctatatggc cactgacctc cagaaaatag ggtgagacaa ctggagttta tgctctataa 198840 aaagtcttga acaatgagat ttggagacat tttggggttg gtgaacatgt caatttgttc 198900 agaggtggca catctagaga gggcatggga gctctgtgtc acccactgtg ttatgccttg 198960 ccttatgaat ctattccgtt tggctgtttc tgagttatat cctttaaaat aagccagtac 199020 atagaactga agaagcagga gagaatcata ggaaccccag atctatagtc agttggacag 199080 aagtattaag tggcctagga ctgcaactgg tgttggaagt ggggacagtc ctatgggata 199140 gagcccttta atttgtggca tctgatgctc agtccaggta gatagcatca gaattaaatt 199200 gaatttttgg ttactcagtt ggtgtcagag cactggggaa tttgttgttg gtgtgagaaa 199260 acacgtgata cctttcaggg tttctcagtt tatttgtaaa atggaaatac taaagtctat 199320 ttcttaggtt gctatgtgga tttcattaga tatcataaat gaagtgcctt ctattttgtc 199380 tttcataggg tagttttttt ttttagaaaa agctaggtat tcttaaaaga ttttatataa 199440 aacagtttta gttccatatc ttatgagaaa ttttttattg cctaaataga gaggctcata 199500 gctctgcccc catagttagg atgtctcaac ccttgtcact gacctaagat tctccaagaa 199560 ttccaaagac ccagctatac cagggaatac agaccagcag cgatcttttg tttgcacaac 199620 atttttttgt aattgaaatt atttaaaaat gggtctatag taaggagatt cacatcgaaa 199680 gctttgatga tgtgcatctt ctgaaaaact aaaaggtact gcagagtagt cttcatagtc 199740 acgatgcgct gtgctgaggc tgctgcttag aaaggtgggg cttcttctcc ctgcttaccc 199800 acgtgtctgg ctgatctctc agctcagctg caggagcttg ttggtcctga agagtggtct 199860 gtctttattt gctgatactt aaactttcct tcttgaaaac tgaatcactg ctatttggtg 199920 cacattttca cccagtctga gtgccacctt acatctttca ttctgcatct tgagaattct 199980 gttttacagt cagaggtgac aactagatca gagcattgac tgctcccaat ttcgctttta 200040 caaaagagag caaaggaagt ggtgatgtta ggtttggggg tgatgataaa gtcagagagg 200100 ggaactccca ctgaagccca cattatgaaa agagctgaac caacttgtac tcttgatctc 200160 cccttaaaag ctggttttgt acctgaatgg agagaagtgc agatattaga gacctggctg 200220 atgtctggtg cttcattgcc ctgaatagac agaaaaatgc agacccttgg gaagcaaagt 200280 gcttgacaga gctgaaagtg aacagcagag gctgggagga agcaggacca aacaaatcca 200340 gaaatcctcc aaggctgtag ccctaggccc agcaggtggt ggtcaggaca aagtaggagc 200400 atgtacagtg ttgagatcag agtcttggga aagcacctgt tacaggtcag agtgaaggat 200460 gatcccagaa acaagtcaga caagaggcag gtaagtgaac aaagtgatca caagtcaagg 200520 gaaatggtga gtccataagt ttgtcagtag caatttactt taactacttc atcttaggcc 200580 atattgtgta catgcgtata ttggtttctt tcaattgcat gtcaaggaga tctgctcctt 200640 tttttttttt tttttttttt ggtacatgtg ttgctgaagt gaacacagat ctgctagctt 200700 ttaatcagaa aatccacact ccagggctgg ctactacaag ttgttttgct ttcttgctta 200760 ctaaatacta tcagaagcta tattaattaa gtataagggt tgatagatat tagaaaggtt 200820 gttgattagc aataatgagc attagaaatg tgcttacatt tttgtgcatt tttgatattc 200880 aatgtgtgtg gataaggtaa aacattttga aaacactttc tgcttttaaa ggagcagaca 200940 ttaaaatcta gtgtctattt caccatatac ccttagcgat aacatggaag gttcgatatg 201000 taaataatct tgtgttgtgc tgttgcttta gaaggttatt ggtcacagta ttccaagagc 201060 tgatttgctg aaatacataa tgagaatatt gtaacatttg gtttcaaaga actttccatg 201120 caacacattt tcagaacctc aaaacagaat agtgggattt tattaaggct gcatgcttac 201180 ttgtaaattg tgtacatttg tagcataatt cagtcttggg cttaatttta taatttcctg 201240 gaagctaaat aatgaaagag tgttaattct cacctgtctt caattactgg gcagcactgg 201300 tgagattctc aaaagaaatc tattacctgt gtgtgactac agtactcagg aactgtatgg 201360 atagagaaga acaagaatga cctgtggatt aaaaagacag aacagaggtc caaagggagt 201420 gagtgagacg ccagcaacag ggacaccttc tggctcagta aaaacacttg ttctgtggtg 201480 gggaatggtt agggttgcac tagctgtacc ttctgtgggg aataggcaac cttgggtatg 201540 gaaaatcact gagacaagat tcaggagacc cagttcagtg ctagccctaa ttggtcatgt 201600 gaacttgggt aagaccctta tcccctctaa gtcttggctt cctgatgggt tagatgaaga 201660 gttaaacaaa atattcttgg ctggggtagc acagtgtggt gaaggcagtg agatttcggg 201720 atctttagtc tctcttacaa tcttaggctc actctgaata tctagggctt cttgtgcaag 201780 ttgtttaatc catttaagct ttaatttttt tatctattaa atgcaggcga taacacctat 201840 atcaaaaagg ctatttttag tattaagtaa aaggtgacat gtgaagtgtt taaaaaactg 201900 cttaataatg ttaccccatt cctctcatct ttccctttac actcacacat tctacaattc 201960 tatgaattaa ggggaaatga ttgatggaaa tttgtggcac aggcagagat ggaatgggga 202020 tgttatttcc tcagtattgg gcttgagtga tagtaaacga tgaagataaa gttcactttt 202080 gaagtggaat ggttaaagta ccattgaggg aatacatgtt taacctaata aactggagac 202140 ccattttgta gttgtattct accccatggg aagtgcaaga gacacagcac accaaaaact 202200 aggaaagctc tacgattact agtcgggact ctggatccaa ctggaaacat cactgtgtga 202260 tggatcagaa tttgaagcat gaggagaatc tgggctaggc gagcacagaa atcatgccta 202320 caccaccagt gggaagagga aactctgtct ctctgtatgt atatatgttt gtgtgtatgt 202380 ttttgtgtat gtatgtatat acatgcatat atattatgtg tatatataac atatatttag 202440 tagatttaaa aattatgaaa ttatgataaa attgtggctt cagtcatcaa caattctttg 202500 ttaagtcatt aatgaatgac tttttttttt ttttttgaga cagtctcact ctgttgccca 202560 ggctggagtg cagtggcatg atctcggctc actggaatct ctgcctcccg ggttcaagtg 202620 attttcctgt ctcagcctcc cagatagctg agattacagg agcccactac tatgctcagc 202680 taatttttgt gtttttagta gagatggggt ttcaccatgt tagccaggct ggccttgaac 202740 tcctgacctc agatgatgca tccgcctcag cctcccaaag tgctgggatt acagacgtga 202800 gccttcgtac cttgcctgaa caaattttct tttataaaaa attgggttgc tccattcctt 202860 atttgacatt ttattttaaa aagtgattta tttataatta taaacttaag caatatagag 202920 gatgcaagga aaaaaaactg aaaaagcaga aatgaatccc aatctaatga aggggaatta 202980 gtcaccgtta gtatttgata aacatgtaga tggacatgtg gatgcagaga tagacctgga 203040 ggcagattgg cagaaagata gataattaac tagaggtgtc tgaagattgg agttgggagg 203100 ggtatcatgg acttgtcctg gaacaagtct ctttaggtga ctcacccagg ggatcagtgt 203160 gtctcacaat attgttcttt aagtcactag ttctctctgt taggatctta tgacatctgc 203220 tttcttattt ttcctcttcc caatttcatt tccaacagtt tcttagccag aaggtaggct 203280 gataataaga caatgacaag tgagagtgct tcctccttca cctccacctg ttttgaaaag 203340 gagtcttgta tgtggacatt cccctctttt ccttggtacc cctcacccct ccttgcggca 203400 tcacatggct atttgagcac catgaacctc cctttcaggg agatctaaat cctgcctaag 203460 gtctgagtta agactgcctg tctttcagcc tcctacctca cttgtcctca atataactgt 203520 atttggcaaa tattcttcca agtgtgaaat ttggagttgg ggcatattct tgttagtgat 203580 gaaggtggaa ctttcttctt gatattttct tgctgctttt atagatttta gcaagttttt 203640 tggaatgaga catcaaaaaa gaatggcttt attcaatgtt cttgagccag aaatctccta 203700 cctgtgaaga ttctggtact cagatttaat acaatcaagt gtctcttgaa attttatgtc 203760 ttagcatgcc ttttattttt atttttgggt gtgctatacc ttatttcagc actactaata 203820 gaaaaaaaaa ccaactatat agacaagaat aatcaagaaa aatacctcaa gggccaatgt 203880 gaaaagattt ttagtatttt ataatttata acattttata atttaatttt tctaagtagt 203940 aaaatatatt taaaatctgt gtatttttaa gaggaagttc caaatgaaag aaatatgaaa 204000 caaacaaagt tagacatggg aaggaaaatg atcaccccat tgctatgttc atcatgtctt 204060 attctcacta ttttaggagt gtcaaggtgg cgtttaggca ccgtgtgact cctttaccgt 204120 gaatcaccct ctgcaacccc caggtgcagg ctgctaatta ttctcttcaa attttctcca 204180 ggagttccct gtttctctgt cttggatata tatttggctc tgcatggtag accaggagca 204240 ccagaactga gacattaaaa tcttttgagt taaatagtat taggagatta ttttcacagg 204300 cgcctttaaa aatagatgta tccaattact gtaattctaa tttttcaaat gctagtcctt 204360 ttgacaagtt gcagctctgt ttaccagctc ttgtaggagt ctcatgattt cccccaaaag 204420 agcagcatga agctgaaatt gtaagtttat caaagcaaat tgcatgcatt ttccaaaggc 204480 aaattgcaga ccaaagccat ttgtagatga atagaaaact acatgaaaga gaacactctg 204540 ctgtgtttgc ctactcataa cttcaaccca aattaccttt taaaacacta tttggaaatc 204600 tatagaactt caaaagggcc cattaatgga tgtgttgaaa atagaaccca acttcttcaa 204660 ctccaaacac agagtttcac tattcaacaa ggaagtttcc cagaataagg tttaagctta 204720 agttcctgaa gttcataggc taaaaatata caaagtttac gttgtagttt ctcatcactg 204780 taagactcac cacatattca aaagaccatt aggaagtcct gaatgtatac tgtgtcctac 204840 cctgaagagg gcacagttta ttaaaactat tatcatatat atctaaacaa actcttttac 204900 ataaaaaagg taagtaaaaa tattatgtgg attaagggat agagggttga aaggactatt 204960 tcaacggctt ttaacaaact cagcagattc aaaacttgaa ttcaggtctc aacttatctt 205020 tcaagaggaa aatgctgaaa gtgtacagcg agtgtaactt cgggtttctg tataatattt 205080 aatgagataa atgcctccct ccctgtagtg tgggttactc agcatttgcc ttgcattttt 205140 attctccagc ttattctctt ctgtgtccag aaggctgatt tccatagggg gcatcaactg 205200 cattccctcc ccagtttcaa ttttgctagt aaaaagcatc agagggagat cagaggatga 205260 aaagtagaaa gattagagca tttattcctc ccaccccacc ccagcttgag ttcaggtctg 205320 acagtgtctg cagcactggc actatggccc tgagggccac ctttttccat gtccagctct 205380 taactaagct ccagtaacac caatgcctcc atttgttcca ccaggcctag gagtggcaaa 205440 ggctcttcac ccttgctagt ccctaggtgt ctacatatcc cttgtaggtt gttacctctt 205500 accacgcctt ggtaaacact cccctcatta agaagcttct ttgaaaaatt ccaactaact 205560 gagcatgcca tgtgttttag gctggggtcc tgacacatac aaatttgtgt atctaatttt 205620 aaaagcttat ttcacctcct gctcttgcat gcaattatag cgcataatct tgtggttaga 205680 gataagcaaa cacgctgaaa ctaaaatgca aatgcaccct ggaatactgt aacttaaaag 205740 ctgccaccaa aataattcta cagcagacaa gtccatcctg cacttaggag atgagtctac 205800 gtatgcacac aggtgctttt cttagcaaga acttcttctt atgtgggtaa ctctaggcct 205860 tctctctggt gtggagtctc tgtcttgttt ggtggtcctg atcgtttcac ttatcatacc 205920 tcctgctgaa cctttccagg caaggcagtg attcaggaaa gaccgctgac agtgtagaaa 205980 gtacacggtt ttgtttctgc tggccagcta gcggggaatc ctggtattca gaaggggaat 206040 caattctttc tttttgattt agggatatgt ttggcagtta ttaattaaca tgtgtgagag 206100 atcctgagaa tttcaaacat ttatttttta aaggagtcta agtttaaact taacttcatt 206160 atataaaact tccttctcct tcctcaacct cacttctttg aattatttta ctttagaaat 206220 ggcaagtttt ctcaaagatt aatgcaaagc tcatgtcaaa atagagctct ctctctctca 206280 attttatttc tactatttta actatttcat ctatttattt atttttttat agttttcgtg 206340 gtccattagt tccatgattt aatttactat tttactttaa aagattttcc cttgccagtc 206400 aagtagtatt ccatagaata catgagagaa tacatttttg aagaaaactg gtaaacaacc 206460 aattaaaact ctttatggat tttcttccac atataaatta ctattctata catgaaataa 206520 taaaaataag ctttggaatg aaagtatata aaaatgtcaa tagaaattct aagtatgggg 206580 taatcagcct tgaggtaatt gatagttgcc tatacttaca tgatttgtaa tctgtcaatc 206640 atttattcaa caaatatttt ccacagctcc tatacacaaa gcattttaag ggtagtatta 206700 aaaacaaagt actttccctt ccctaaaaat ctttataatt tatttcagaa gaagagaaag 206760 gtactttttt tttggcagac ggggacagag tctctctgtg ttgtctaggc tggagtgcag 206820 tggtacaacc tcagctcact gcaacctctg cctcccaggt tcaagcaatt ctcctgcctc 206880 agcctcctga gtagctcgca ctacaggtgc ccaccactac gcctggctaa tttttgtatt 206940 tttagtagag acggggtttc accgtatttg ccaggctggt ctcgaactcc tgacctcagg 207000 tgatctgcct gactcagctt cccaaaatgc tgggattaca ggtatgagcc accttgccca 207060 gcctcgaaga aaggtacttt ttaaggaagt gcaacgatag tggcaaataa gagttccaag 207120 cagaatgaag cctcttcctg gtagtgggaa ctggggcttc tggtctcagc cattgatcaa 207180 ttatcactga caggaaccat gagacctgtg caaatgaatg actgtgtaca gttctagtca 207240 ttgatctgat cctcaaaaaa agatgtgata aatgtggatt aattgaataa gggattgtgt 207300 gtgtgtatga gtatgtgtgt gtggaaggga gtgtaaagta tgcaactact ttgctatttg 207360 aagatagatt aaaatcacct ccatctcttc cttcagcata gaaagacaaa acgtgggaga 207420 agtgtgaatg caagtctatt caccagtttc taggatttgc tctccgggtt tggtgggtta 207480 ggatggggat caaaatttca aagaaatatt gcacagccaa gaaaataaaa gtctagtata 207540 cctattcagt tgctaggcag ttactaatag gttgttgata attcaactac tggtacgctt 207600 aggtaggctg aaatgcaatt aatttgaaga attacgcaga aaaaatcctg gatgagagac 207660 ctagaagtga ttaaggaaat aagagtggct caggcacttc tctaaccatt catcaactgt 207720 gtaatggaac acaagcaatg cttttcctca acctttaaca gagtggactg ctgggaagat 207780 gcattatgac acagatccag gaaagcatca tctctgagtc tttctgcctc tttgtgttgg 207840 ttgggagagg ctaaaagagg tttctgaaga ggaatgacca gtgttagaag aagtgtagca 207900 tgtgtgctac catttcaggg cattatagca gagaactcag aaaggccaga atcttgtacc 207960 aaactgtaac cacctctttt ccaggtgaga cagccagcaa agaaagacac atgaagcaaa 208020 tggagccaca cgtgatgatc atactgatct ctgctaaatc aagctacagc acacaggagt 208080 cccaaagctt gctgggcctt ctctcacctg catgttcact cttattaaat tatgatgagc 208140 cctctgacaa actgtcatat ttgaaggacc ttttaccaga gaagaggagg gggaggaaga 208200 gagaaatcaa aaaagataag caaaagggct gggcttgctg tgtgatcaca gataaaatac 208260 caaacagtta aataatgctg gagggtgacc tcttatgtga cccaatcaga gatttgacat 208320 ttatctcctg aatgtgacat cccatctcat caaggatttg ggacagtggg gatgaggaga 208380 cacgttctct ctccctttcc ttgctcagcc ttgttctctc tgtttactct ttgggcttca 208440 gtgcactttt gtggccaagc ccagtttgtg gcctgcccct tgcatggcca tctctgcagt 208500 atcagtgaaa actcaacagc ccctctgtgt ggccacactt tttttctttt ctaaaaacaa 208560 tgagatactt atatccaccc catgcaaatt cctccaggat attgctcttg agtcatcctt 208620 gagaaatttc cgtcttgaaa catgtctatc tccatgttgg gaaatttaat tagtactcct 208680 attgtaggga ttagggaaag cacaactaca cttttcatca gcttcaatga tttcaccaaa 208740 gggcatttat ttacttagtt ataccagctg tttgttcacc agataccgtc tcctttgacc 208800 ctatgtgcac acaaacccac gcacagcgga tgttgactat gagaactgat aatatcacac 208860 ccattttaga tacatcattg aggcaaaaag ggacatttat gggagatatt tttctttttg 208920 ttgtggaaat tctgacaatc tcattttatt ttctcattca aattattaaa tgattctctc 208980 tctctctctc tctgcttaca taggggtcat catttgttct tttaatccat ttcaagagca 209040 tgtccccttt tgccgtattc agggatgatt gccccctacc tgaaccccat cttgctccaa 209100 caaacaagtc atataatcag agatcgcact cttagtcaaa agtctgacca gttaaagaat 209160 taattgcctg cgccagggag tatggaaagc aaaaaagaaa ctctgttatg atttctatag 209220 atggaaggag aaatgcacta tttgaatgat agagtttaat tgtcattatc tagaaaagat 209280 acttcattta aacttctcct ttacttaaaa taaacacctc aatgctcaca ttcctgcctg 209340 gaacattttt agcaataact gctggttgtc aatgacaaca atcatattta attgttcatc 209400 ctgacatgct ccagcactct attaagcaca gattactata gattgaataa atgaatagca 209460 aagatgctgg ccaagagctc tgaacgtatc agtggaaata atgaattgca tcatccttcc 209520 atgaaaatgc aggaagggcc aacacaggtc aagagcttgt tagagtttca ggttgtccat 209580 tttgactgaa ttaaaaagaa agcaagttta ttatggatta tacatgtaag cagggagagg 209640 atgaaggtca aatttcttga ttaggtatta tttagctatt ttaccatatc tcaaagttat 209700 aattcagaaa tgaaatgaag tgtatcttgt ttcttatatg aatttttaaa aggtacacag 209760 tagatagtct tactgaattt tagtttaatt gcactttcat ctcaatatta ttattttatc 209820 aagccagata agtaaataat atcctttcat caggtatcag agcacagttg taatataaat 209880 gggattagca taatgaatgc ctttggagaa aattataaaa tgtcctttca tgcacataca 209940 gttttataaa catgactttc ctttgtttta attcaatctc tgatggaaat gcacaaattt 210000 taaaattctg ggaagaacaa acttatctga tcatttttaa gtaattgata gatcacagta 210060 gaattatgtt tttcttttaa gtgatgagga tagaaaattt gagttgttta attagacatg 210120 tgactgaacc cagacgtaag gggatcactt tggtgccctg gaaagtactt tgtactgaat 210180 ggggaagtcc agatatcata ttctggtgtt gggctaaata ctaattacaa aaccatcaga 210240 caaaattatt gttattatta ttttgcagca agtgactgtt aacattgaat gtgtgttatc 210300 aacttaaaag tctattcttt cttgaaaata tgtgtcataa atattttctc ctcaaagaat 210360 aaacacacct tttataaatg agttgattta ttactgaact atctatttat gacagcatgc 210420 ttcttccatt tatccaataa ttatttggtt aacaatcaca tttcataggc ttaatgtttt 210480 ataattgttt tggtaaacct cctgaatatc tctatgtgta cagaaagcag ggaatgggca 210540 ttttaagggg ctgagatttg caaactgtcc tttagaaaat ttgtaacaat gtacccagcc 210600 caataataaa caagaatgtc tttccattga ctataccaaa tttctacttt cctttaaagt 210660 ttggcaaaat tataagaaat attaaattat tattatttat ttatcatttg ttgtactgat 210720 aaataaccaa tccatccaat aacaaataat ttatccaaat tataaaatat taattattat 210780 ttatcattta ttaataaatt atttattcaa taataaataa ctcatccatg ttatatatca 210840 tgtgttattt attttaataa tgaataataa ataatattta gtatttatta tttgattatt 210900 taatttttaa ataaatgagt ttgcattttt aaatatattt attgacaatt tgtcaagttc 210960 tcttgctaat ttccttgcct tcttattcct agttagactt gcatgctatt tgtgttgcaa 211020 atatttctca gttggtcaat tttcctttct ttttattata gtcaatgcaa acttactaca 211080 aaagtagtaa ttttaaggtt tctctggcac cagaataaat gcatgctaac caataataaa 211140 tgatacagta taattttaaa gtccacacat tgtgtgggag ccaaatggaa cactgtcttc 211200 acaatgtggg gcacagtctt tgtgaggaca actcctctat gcccagcttc aattatgtag 211260 atttttgaga gtgtcagaag tctgaagtag gatcagtgga taggattcta tggtcttatt 211320 attattttaa ttatctggtg ttccaaaaag tgtttcctga aagttaaaca atgagagttg 211380 gtttccttcc actttactaa gtggtgtttt attttttcct tcttagacta tatgtatgat 211440 ctgtaattat gcatgaggtc aaattgatga gggctagcca aatatgctaa aatgtcagtc 211500 tgagaatttt aagtgtaact ctagcagaaa ataagagcaa acttgtccta ctaatactga 211560 ctaccctgga ggacacctgt actttaatgt ctaatgaatt gtttttcatt gagtcaattt 211620 tttttacatc aatgttcatt gaatatttat tctgcatcaa accctgtatt cagccctggt 211680 tggttaaaga ttatctattt acttatcttc tatgtatcta tctatctatc tattatctat 211740 ctgtctgtct atctatctat ctatctatct atctatctat ctatcatcta tctattcacc 211800 tatcatctat ctatccattt atctataacc atctatctat ctatatctgt ctatgtctat 211860 ccatctgtca tctatctatc tatcatctat ctattgtctc tattcattat tcatctatct 211920 accctatcta tctatctatt agctacatat ttagctagct ggcatctatc tatatgtctc 211980 tatcatctat cttgatatag atatacagat agagatacag ttttttcctc aggaaagtca 212040 gtgttaaata aggctctcaa ctgagcataa ggatgaggac aggtaaacga taggggaatc 212100 taattcaaat gagtagttca gggaaggctt cttcaggaag gggatcatta acactaaaac 212160 ttgaagggca catgcactta tgtgttatgt ggataaatta ccaggggaag tactggagag 212220 aactagagag aaagaagcaa gattcaacat ggttttttaa aaaagcgtga tgttaaaaaa 212280 aaaaatttac aggaaattac cctaagtcag tcagtgtttc ttaaggctga gcattaagag 212340 aaataattct tggggatgtt aaaagctcag atgtgtggga actatcttag gcctgttgaa 212400 aagaaactta atgaggccac aacaggtctg aagcagtggc aatcttgaaa aaaaacacag 212460 aaaaagacag agactgaaga ccaatgcaag caattctaat tccagaccca aagaaatgag 212520 ataataatta taatttctaa ataaagtcaa ctttctacta atgtacagaa agagaaaccc 212580 agggcaatat ttaaagtgaa gaaatgaaaa aaagataaca tatctgtaaa actgtgcatc 212640 tataacttaa ttttgtaaga ataaatactg cttttactag taacttaaag aaaaaggttg 212700 tgatttagac aaataataag gaagaagtaa attgaattca gttagtgacc gattagaaat 212760 atcaagtttc ttgactcaaa caccctattt atttttctaa gttagagtaa ggcttagaaa 212820 acagcaagta tggtcttaaa aattattagc aaaactcaga agttctccct caaatcagga 212880 attcctctct ctctttctta ctcacatgca tgcacacaca cgagcagatt ctaatcacag 212940 tgaaaaatac caagatcgat aaatatgcta ttcagatata agaaacttta atattttata 213000 atatttgccc tatattttta aaggaataat agggttatag ttaaaacctg ttttgcatta 213060 ccatctcagt cttacttctt tcacttcttc cctttgcaaa aaatgtcatt ttactgaaca 213120 ttaaatattt agatctaggt catttccttt aaatgctgtc tgaacattta cgtatgaatg 213180 tattacaatt tatataccca ttcctctaat aatagaaatt taatattatt cccagttttc 213240 gatattacaa aacattgcaa taaatatcaa tatttgtatc tctttgtgga ggttatcaaa 213300 gttccccttt agcgttccta tttagaaatg ggagttctaa gttgcaacag atactggtgt 213360 tactaaatct catccttttc ctctattttt tagttcatgt ttctgccccc acttgtacct 213420 aatcacactc accaaaaggg tggtaggtgt ggctgggttt cttgcctgtc actgtgtgat 213480 ggtttgaagc agctaatcct ttcaaaagct aaatggaatg caaagactta gccctatttt 213540 agagataaag aaggctaagt tagaacacac caagtatgtt ttttagatat catcaagcaa 213600 atggaatatc cattattgta actgaaaagt ctgggctgtt tcaactgagt tcaaaagcca 213660 cagtaaaaca tcaatttaga agcaagctgt tagagaaaat atgcctgtga atgtgtatgt 213720 ctgtgtgtgt ttgtgtataa aaatatatga tgtagcttat aacacaaata agtcagcctc 213780 ctacccacta cacatgtgtg cacgtgtaca cacagacaca cagaaaaaca tgcattgtat 213840 cagggctatt tgcagaccac ctataatatt ggattataaa ttactgcctt taataacata 213900 gttttgccgg cagcttggta ggaagtcccc agtaagaatt aatttgaagg atatagttgc 213960 aacgtctttc tactttccaa atatttccct tgtatacttc aacagtgcct ggtatttcaa 214020 cattagtgat ttattcactt gttttcaggc actgaaatct ccaaaggtcc tactttcaaa 214080 ataaaatttt aaaatttata gaagaaatgt attatgccac taagatcaga atgattgaat 214140 agatctaaag catttataac catttccctt tcaggggtgt ccaagggaga taatagagtc 214200 atagattctt agttctgttt ctggttgggc cagcgaaata ccttcctcat cccttttctg 214260 cttgtcacta gagacagaaa ctaaaagcca tggctcaggc tgccaaaagc ttaaaacaaa 214320 acaacaataa caataaaata aggcaggttg gacaagcttg tgggatggtg agggtgtaac 214380 aagtcctgga gaaggtatgt tccaatagac agcaggcaag agtagatggg agagggcttc 214440 ccacagtggc tcacctagaa cacatctcta aatgtcttct ttaaacacca tttcctttcc 214500 ccagcatagc tgataaactc tctctatatt ctcacccatc gaggcctctt tttatcacac 214560 ttcatttcct tccttattct aactctctgt gccctcaggt tctgagctac tcctgccatg 214620 ggcagcccct ccacaccctc aacctcaaca aggctcatgt gattctctct tcattccagg 214680 gcaatatttc tcaatcttgg catgattgcc agtttgagca gattaattct ttgttgtaga 214740 ggcaatcttg cgcattatag gatgcttgct agcatccttg gcctctagta attagatgtc 214800 agtaggatct ccccagttgt gacaaccaaa aatgtcccta gacatggtca aatgtgccct 214860 gggggacaaa caattgagaa ccacttttct ggatataatc tctatctcat tacactggta 214920 attgcaatgc agagtagtgt caaacataaa taatgagatt cagaaactat gtgaagtata 214980 gtgtttatct gagtgcaaag cttgaagatg accacctgga aaacacatac tctaaaacaa 215040 tgggtcttcg ttcctaagtg gataagtcaa ggtttcattt atatagggag agttgcaaca 215100 ttttccatac aaggtcagtg cataggttat ggcaacttga taagttacag attgccataa 215160 taaaaggaag attgccttga cattccatga ggaggggtga tgatctgagt ggggtcttat 215220 ctctgctgcc acaaggcctt tcttaatcat ttataggaag gggaagaagt tccagctgca 215280 cactatgtga ctcatgccac atagccagaa tcctctctgg gttcaaaatg ccttaaagtt 215340 ccaacagttt caagtttgaa ttatttaatt ttacagtaga aaaagatgtc aggaagagta 215400 ctgagaaagt atctaaccca gaataaagag ttcggagagg gatccctaaa ggatgtcaga 215460 aatgtcaacg catatggttg ggaaagagtt ttctaggttg agatacatca catacggaag 215520 cctgctgata aatgataatg aaacatcagg ggaaatatta agtaattcag agtaccagca 215580 gggaagtggt gaaatactgc tggaggaggt gggtgaaagg aacaggatga agagtgttgt 215640 gtactaagat gagtttgacc ttctcctgag gtcaagaggg gaccaccgaa gcattttaaa 215700 cacacaaata gtttcatttt agtaaagttc ttctggtagc ctgtggaaat caaagtcaac 215760 aaacatagag actattagga gactattata catcttagat aacattcgtg taatgtttag 215820 ggcaatgtgg tcattgacta ggtcaactag gtaaatctta gtgtcatcct ctttctacat 215880 cataatttca acaaagccat ggctgttggc gattcaaaaa ggaaatatca ttgtcacata 215940 gtgagtccgg aaagaaggta aaacatgctc atgagctctt actcatattt ttcattgtat 216000 ttttttagaa tttaattttt acttattatt ttctcaatct ataaaatttg aaattctcac 216060 aagccttagc atgtaaactc tgttactgtc ttcacacctt tgggagatct catccagtct 216120 cagggccata aatataacct atattttgtt aactttaatt tacatctcta gcttgaattc 216180 ccccacttaa ttcccaaaaa caactcaaca tatcaactta gatgcttaat agggacccct 216240 cacaatctat cagtaaattc tgaaagcact ataattaata gacatatacc tatacctaac 216300 tctctctctc tctctctcac acacacacaa atggttagtt tccaacatta tttcttctta 216360 ctttttctct aaaactggtt acagtgtgag tttccatttt ataatcaatc tttactcagc 216420 taacactagc tattgcgctt tatagttaaa cattagactg gccgttatgg cttactatta 216480 tgagaatcaa tgttttattt gacactttgt gcctcaaagc tgcttattat taaattgtgg 216540 cagcactatt acttcccaaa tgtgttggcc tcaacctaat ccccaaatcc ttgtaggcac 216600 atgtccatgg gcatgttatt aactgaaagt acttactcac acagccttac caactttaaa 216660 aaaacaagga aaatctgaag gaaaaaaaag tcatgtaata ttaatagcac atattgtatt 216720 ataaattatt ctgtaacaaa taagcaaatg taaaaatgat gctgtattca ccccccaact 216780 taatcttgtg tagtggcata ctgtgaaata gcatatctca tttcccagtc taatgagtta 216840 ttgtaaatac tgtttggtca aaattacatg tgtataaaac cttaggtctc gtgtttcttg 216900 atatttctgt gtttgaagtc tgtggtaact tgtcatggca gcctgaactg actaagagag 216960 gacccattct gatgctatca aatattaaca aataattgag atcctgctcc actgaagact 217020 tctttgtcct caattgtaga tggagggaat gggctgttaa tagaaatgat tgtaagaaag 217080 tccaaagtgg tttggtatgg tacatttaat aatttaaatc tgattatgct attttccctt 217140 ttggtttaac atgtatcaaa caaacaaaaa gtcatgtcct ggtcatatgg tgccttagat 217200 ttagggaaaa aaataaaaat agaaaataaa agagaggaaa agagatacct caatcctttc 217260 atcccactgt gcttaactga aagaactgca tttgataact ttactttgct atcgtttagg 217320 agactctcct taatttgatt ctgttcaact tatccagatg ctatttaaca catgtcttct 217380 gtagaagctg tcttacttcc cacactccct cccactttta tacattagtc aaaccattac 217440 ctcatccctg aaatgacctc tctccctgaa tgcctaagtt tacctactcc tcaagacctc 217500 ctcctatttt atttatatta tgcttttact ttttaattca tgatgttcag tgtgaaaaag 217560 ttgtaagatt aaaaacatta atttccattt taaggaattt atagtattct aatcggtaaa 217620 acactttcaa tacaaactga tatattatac aaacaataat atagccttat acatgtatac 217680 tattagtatt ctaattggtt aagcacactt tcaatataaa ctaatgtatt aacatagctt 217740 atacatgtaa tatatatata aaatgtataa ggctatgtta taattattaa tactatatta 217800 aatgtattaa gcaaacataa aatagcctta tatgagtaaa aagtagaagc gtctggaggg 217860 aataggtgaa attcagagag gaatgtttaa caattttgta gaatgggaaa ttaggagatt 217920 gggaggagaa gttcaggaag aattcacata actgcaatga tcctcccttc tgatactctt 217980 atctgcccta tcatttgtga catcttatac attggacccg ccattttctc tgtgtacttt 218040 atctttgtaa tgagattgtg aattcatgtg aagagcagac atgagttacc tattttctct 218100 atttgacaga atgcgctgca gagttcctat catttttctt ttcttttctt ttttttgaga 218160 tggagtcttg ctctgtcacc caggctgtag tgaggttccg cgatctcgga tcactgcaac 218220 ctcaacctcc cgggctcaag agattctcct gccttagcct cccaagtacc tgggattaca 218280 gacacgtgcc acaacaacag gttaattttt gcacttggag tagtggtggg gtttcaccac 218340 attggccagg ctggtctcga aatcctgacc tcaagtgatc tgcccatctt ggcctctcaa 218400 agtactggga ttacaggtgt aagccaccac gcctggtccc attttgttaa agttttgaca 218460 ttttctgaaa tctggggtct tgacactaat ccattttcag caattgaaat aaaaaaatta 218520 cttgatgaca gggaaggcaa taaatattat taaccaaagt attcttctaa tgcactagaa 218580 aatgatggga agggcagaga atagtctcaa aaacttttat caactagaac tgtgtgatgc 218640 aaatgctcag cttcatattt gcctcaaatg aagctgagct attctctttg ctttcccatg 218700 tagggagctg gacttggact acccacagcc tttggtcggc tgatggctgt ttaatcacaa 218760 acaaagagat tccaggacaa gtaacaatag cttttgttta aaaaggactt catatgtcac 218820 aaaattcatt atcacctgtg cattggttag ctcaggcttc cataacaaaa tacttcagac 218880 tgtgtggatt aaacaacaga tcttatttta tcatcgttct ggaggctgta tatccaagat 218940 tagcctgcca gagtggtaag ggtctggtaa gggccctctt cctggcttgc agatggtcaa 219000 cttatcactg tgtcctcaga tggccttttc tctgtgtgca cacagaaaag agagagagag 219060 ggtgagatag acagagagtt agatctctgg tttctattct cataagaaca cttaattact 219120 ctcttatggt ttccatttct aaatacagcc acactgggag ttagggcttc cctatgtgac 219180 ttttggggag acacagacat tcaatctata acaacccgtt accacctgga atcctcagat 219240 tagtaaagaa ggaaggacaa gaattaatat aaccatttgc caatgaagca ctgaatatca 219300 gggagcttac agattgttcc aaatcataga agcagcaaat cttagaattt ttgaaaccag 219360 aagttgtgtg caagtgtttc ttccccatgt ttctgtccat tactgatgtt ggtgccaact 219420 tggagttcaa tgcagaagtc ttgtggaata tgagggtagg aaagctgggt tatgtgcatt 219480 ttagaatgaa aatgtgaacc atctagaatt ttatctttat cttggctttt aaaaaaaaga 219540 attttccaga tgcacttaat gctctaggag gtaggcagag gattagaaaa gaagaataag 219600 acaaagttga atgataatga gcttcagggc atcagaataa gacctctgga tctgaatgtt 219660 tgttatagga tactttttag aaaaaaaatg tgttatttta aaccatgttg tttgtcatag 219720 tgaaaggatt atttatattc attacttgtt aacattggtc ttttaacgtt tttgtagctt 219780 cctgtaagca ttcatgaaca acaaaaatgt tttcttttaa gagagtaaga aacaaaaagg 219840 acatgcctat aattcttatt ttgaaataag ataaaattac ttagatacaa ggagatattt 219900 tgggagaaga tgtcttttac tacttaataa aatttacttt cttcctcaaa gataagaaaa 219960 caacagtaat aggaaccaga acaaaacaac cttcttgatt tctaagaaat tgaattaatt 220020 ttcccttcaa tgataatctt tttcatcccc ttcttttttt tttttctttt ttttcttttt 220080 tttttaacaa gacctagcat cagctttggt agagcaactg actaaggagg tacacacctt 220140 tctttgaagt taggaccttc tggctttccc taggtcatga agacatgtca ttttgcccag 220200 cacctacttc acctggctca gaaggaggcc aatgcacaca ctctgagtgc ttatctcact 220260 ttccctccat tctgcatatt caggcactgt tcttagcaac acagcctttt ccacaaggag 220320 agttgcaaca catttttctc aggaggaggg agagggaagt cgactttcct actacttgct 220380 taaaatactc aattgctccc cagtgctcat gggatcagat acccactttg taaacttctc 220440 caggaggttc tgtgggggcc tgccttctct ccctccccag cctccatttc atcgcttccc 220500 tattcacatt atatgcccta cctcagcaaa agccaggctg tttcttgact ttttgctggc 220560 tgctttgtgt ttttgttttt gttttggtaa aaacacataa tgtcaaattt accatcttag 220620 caatttctaa gtgcacagta cagtattgtt aactatatgc acatcgttgt gcaacaaatc 220680 tataaaaatt ccatcttgca acactgatat gatctggctg ggccctcacc caaatctcat 220740 attgaattcc catgtgttgt ggggtgaaac tggtgggagg taattgaatc atgggggcag 220800 gtctttccca tgctgttctc atgatagtga atatgtctca tgagatctga tggttttaaa 220860 aataggagtc tccctgcaca agcgctcttt tcttgcctgc tgccaatgtg agatgtgcct 220920 ttcactttcc accatcatta tgaggcctcc ccagccatgt ggaactgtaa gtccaataaa 220980 cctcttcctt ttgtaaattg cccagtctcg ggtatgtctt tatcagcatc atgaaaacag 221040 actaatacaa acactaaaat tctatgccca ttgagcatca aatttccttt tcaccctttg 221100 ctatcccctg gcaaccatca ttctattttc tgtttctaag agcttgacta ctttagatac 221160 ttaagtatct catatgagta ggattatgca gtatttgtct tttagtgaat ggcttatttc 221220 acttagccta aggtcttcaa tatttatcca cattatagca tatgacagga tttccttctt 221280 tttcaaatgt aaaaaatatt taattacatg tatataacat ataccacaat ttgcttatct 221340 attcatccat ctatgaacat ttaggttgct tccacctctt ggctagtgtg aataatgttt 221400 ccatgaagat ggtatgcaaa tatatctttg agactttgtt gtcaactatc ttggataaat 221460 acccagaagt gggattgctg aatcatatgg tagttctatt ttcaattttt ggaaaacctc 221520 catacaattt ttttatagca gctgtaccat tttgcattcc tacaacagca tgcaaatgtt 221580 ccagtttctc cacatccttg ctaacactct ttgtcttttg tttctgaaaa tagccaccca 221640 gacaagtgtg aagtggtatc tcatggtttt agtagcattt ccctggtgat taataacatg 221700 gagcatcttt ttatgtattt cttcaccatt tgcatgtctt tatggagaaa tgtctattca 221760 aagacaaaaa acaaaaaaca aacaaacaaa aacaaaaaaa cacactaaat taattaatta 221820 attaattaat taaaaaatta gccaggtatg ctggcatgta ccttgggagg catgctgatg 221880 tatacctaat cttctcggga ggctgaggta gaagaatccc ttgagcctgg gagtttgatg 221940 ctccagtgag ctatgataat gccactgcac tccagtcgtg ggtgacagag caagttcctg 222000 tcacaaaaag aaaaacaaaa actttaaaaa acttatatac tttgttattt ttaattttaa 222060 aataattcta tagctttttt tgtgtatgtg gttaccttgg agcttacaca aatatcttat 222120 tgtattacag tctatttaaa gccgatagaa acttatattc aattatgtag taagactaca 222180 cttcaatttt ctcccataca ctttgttatt tttatcatga tttatattta ttcatattat 222240 gtacctttca acatattttt agttatagtt attttaatac atttttcttt taacttttat 222300 acaagtatta gagcaattta caatgattac agtaacagta ttatgtactt gtctacatat 222360 ttacctttgc caacgagttt tatattttcg tatactattg tgttgctatt ttgcatcctt 222420 tcatttcaac cttaaggact cccttttgcg tttcttttaa ggcaggtttt gtgatgatga 222480 actccttcag cttttgtttt tctgtgaaag tctctatctt ccctttttgt tttaaagaag 222540 agtttttcca gatgtagtat tcttgattat cagtttcatt tttttctttc agcactttga 222600 atatattatt ttactccttc caacccaaaa agtttctgct gaaatgtcta tttatagtct 222660 catggaagtt ccttgtatat gacaagtcac tctttttctc ttgccgcttt cagaattctt 222720 actttgtctt ttacatttga caatttgatt ataatgtgtt tcgatgtgca tgtattcatc 222780 ttatttcgtg tctctgggct tctgggacct ggaacttact tctacagatt tgataagttt 222840 tagtcattat tacattaagt cacttttctg gttctttgtt tcttcttttt ctgggacttc 222900 agaatgtgtg tgttggtcaa cttgatggtg tcccataatt cctgtaagtt ttcttcactc 222960 ttttgcagtc tttttgtctt tatgctcctc taaattattt ccagtgatct gtcattggat 223020 ttgctaatcc tttcttttgc ttggtctagt ctgctgtgga acctctctag taaatttttc 223080 agtgtacgtt gttcagccca tgatttctgt ttggtacttt ttaagatttc ccatctcgtt 223140 gttgaaattc tcactatatt tttgtgtcct tgatgagcat cttgtaatta tttttaatta 223200 tctattggat aaatcatgta aggttggttt ctgtatgttt atcttgttcc tttgtttaga 223260 acatttttac ctgattcttc attttttctt gaccctctat gttggtttct gtatattaac 223320 aaagcaagca cctctcccag tcttcatgga ctggttttat aaaagagaac actttcacca 223380 acaaatacag ccaaaaataa tggtggccta taataattct ttccctcctg aggaggaatt 223440 aggcagctgt gatttttgtc catttattct gtgttgagcc agagagaggg tagctatggt 223500 ctacaagccc aaaacaccat tttcatactt ctctgagcag cttgactgtg ctgggcctgc 223560 ttaagtcagc actggttaga aatgctagtt attttggcat ccatggagaa aagttagggt 223620 gctggacaca tggataaatt ctttcctttc ctatggagaa tctttcagct tgttttttaa 223680 aacctacttg ctatgtgctg agcaaggggt ataatcactg gcatctacca ggctaaactg 223740 ttgccaacat tctcccctgg gtggttggac tgtgccagac ccatcacagc cccaatattc 223800 ataggacagc aaccagtttg ctgagagccc ccttgcagaa gtggagtgct gaacacacaa 223860 accaatctct tctctccctt gggtgaagct agaaggaagg gcatatgttc ttgatccaat 223920 ggcactgtgc aagggaggga tttctggtta gaaagtatcc tgaatttccc tactagcttc 223980 gacaaatctg gttaagcttt cttctgaggt gcaggagtct tttaattcgt ttgtgattac 224040 tcacagagtg ggctgatttt tgaattgttg cttaatcagt gtgtttgtgg gagaaaatag 224100 gaagtccagg tcttcctatt ctgccactgt gctgatgtca ccttttgctt ttgtcttggt 224160 aaccaaaaag aaaataccta tagaacataa acattataaa aaaaaaaaaa aagaaaaaaa 224220 agaaaaggtg acatcagcaa gatggccgaa tcagaagtcc tggaccctat ctcttttctt 224280 ctgggacttt tataatggat atacttgttt acttggtggg ataatataag ttttttattc 224340 tttctgtctt tattgttttt ccttctgatc cccttggtca ataagttcaa ataacttgtc 224400 tttgagttca ctgattcttc taataaatga agagtgtttt tgaaactctc tagtaaagtt 224460 ttcaattaag ttgttctatt cttcagcttc agaatttcag tttgaatctt ttttgtagtt 224520 tctaactcct tattgatact ctcattctgt tcatgctttg tttggttgtc cgtctattta 224580 tcttgtagct cattaagatt ctttaagata ttttgaatta tttttttaga aaattcacag 224640 agctctcatt ctttaaatat taatttttag agatattttt tcttttgatt gagccttatt 224700 tccctgtttc ttcatatgct ttttttggcc aggatttact tatttggaaa aaaagatcta 224760 aaattctcag gccataagga ctggcttcat gcaggggaag atctttacta attattctag 224820 tcagagattc tttgggcctc tcaaatcttt tctaaaaatg tgtcttctct gtgcttgttt 224880 gtgtaatttc ctaattacaa tggtatatag gattttaaga aaatctcata atttcttgct 224940 ccttccactg tctgtctgtg ctgctgctgg ttctctggtg ttgcaacaaa ccactccttt 225000 gttctcagtg gctctcaggc atccaatcta ttgcagctca tcatcaatgc tcttcaccag 225060 gtgaaacaga aaccagttcc atagacagct tcactgaaaa gtcagaaaat tttatgtaca 225120 ctcacactcc actcttctat ttccctctca aggaaaaatt tgtgagttgg gcatgttctc 225180 ctgattgcac taattgtgct ggcttggtgg gagggctgtt agtgaaatgc agcaggtttt 225240 cttactcatt tcaatatagc tattgtttgc tctggggtat tgtgacttct taattatttc 225300 cagagttctc ataaagactt tttgaacata tattattgtt aaatttgtat ctctgttgga 225360 taatgactct ggggttctta atctactatc ttgctgatgt aacccttttc aaaacttcag 225420 acttttaaaa cactttttat tgtgataaat tggagacatt gtatcattta cagtgcataa 225480 aaatttagaa caacccataa ttattctctg ttttagtatc ttccctttca atatttttcc 225540 atgcttttta taatgttgct attataatga acaagcttta tttaacatta tattctaagc 225600 actcaccgta aaattataaa ctactcatag aattatttta gaagttttat gaattctgct 225660 ctgagagcat tcacctacat atatatatat atatatacaa ctttttgctg ttatcaataa 225720 tagctaatat tattgctaat gatacgattc tatacctaaa aatctctaaa gacttcacca 225780 aaaggctcct aggcctgatg aaccatctca atgaagtttt gggctaccaa attaatgtac 225840 aaaaattagt agcatttgca tacaccagta aggttcaagc tgaaagtcaa atcgataacg 225900 caaacacatt tacaatagcc agaaaaaaat aaaatatcta ggagcatatc tagccaagga 225960 ggtgagacct ctcaaagaca accacaaaac actgctgaag gaaatcatag atgacgatat 226020 cattaaaata tctacactgc ccaatctata ctttcaatgt tatatgtacc aaattaccaa 226080 tgttattttt taaaaaagaa ttagaaaaaa gcattctaaa atttatatgg actcccaaaa 226140 gagcctgaat aagaaaagca atccttagca aaaaaaaaac aaagctgaag gcatcacatt 226200 gcccaacttc aaaatatact ataaggccat agtaatcaaa acagcatggt actgttaata 226260 aactagacac atagaccaat gaaacagaat agagaattca gaaataaagc agcacaccta 226320 gaaccaactg acctgtgaca aaatgggcaa aaataagcaa tgaggaaatg actccctatt 226380 caataaatga tgctgggaaa actggctaac catttgtgga agaatgaaac tagaccactc 226440 cctctcacta tatacaaaaa ataactcaag atatattaaa gacttaaata taagacctca 226500 aactataaca attattgaag aacacctaca aaatactctc tcaagtatca gcataggcaa 226560 agagtttatg actaagtcct caaaagcaat agcaaccaaa acaaaaactg ataattggga 226620 cctagttaaa ctaaagagct tctgaacagc aaaagaaact atcaacagag taaaaaggca 226680 ccctacagaa tgggacaaca tatttgcaaa ctatgaatgt ataaaggact aatatgcaga 226740 atctataaag aacttaaata aatcaacaag agaaaaagaa agtacaccat taaaaagtgg 226800 gcaaaaagta taaaaagtat tctcaaaaga agacataaaa gtggccaaca gacatataaa 226860 aaatgctcaa catcactaat tagagaaatg caaatcaaaa ccacaatgag aataatacct 226920 cacaccaagt gacacgcaca atcaggatgg ctatcattaa aaagtgaaaa aataacagat 226980 gatggcaagg ttgcagagca aagggaatgc ttatacatag ttggtgggaa tttaaatgac 227040 ttcggtccct gtagaaagca gtttagggat ttctcaaaaa actaaaaata gtactacaat 227100 ttgacccagc aatcccttta ctggttatgt aagtggaaaa taaattgtcc tgtcagaaag 227160 acacttgctc ttacatgttt attgcagcac tattcagaat agcaaagaca aggaatcact 227220 ggataaagta aatgtggtac atatacacca tggaatacaa tgcaactatg aaaaataata 227280 aaatcatgtc ttttgcagca acacagctat aactggaggc cattatccta agcaaattaa 227340 cacagaaaga caaaaccaaa tattgcatat tatcacttat aattgggagc taaactttgc 227400 ctacacatgg acataaggat ggcaacaaca gtcactcggg acttctaaag gtaggaggta 227460 ggtggggaga agagttgaaa aacttcctat tgaatgacaa gatcagtaga agtccaaacc 227520 tcagcatcac acaatatact ccataacaaa cctacacatg tgccccctga gtctgaagta 227580 aaaaaattaa aaactaatat ttgtataaca gtatctctgt gttaacatct accaagaatt 227640 ctgtctttta tctcatattc ctatatgtgg aagatttcat ccatccaaga gtggtaagca 227700 attgaaatat gatcatgttt acatagaaaa actagcatat ttaagatatt tttagcttaa 227760 aagagcagaa cgtcctggtc ttttgaaagc cctgcaagat aatttcaaga agatgtatca 227820 gcacatttta aaaagataga ccatctagga cagattttga gatctcaaca aggtcactaa 227880 ttctttatta cacagtatcg ctaactagta aggttgccaa aatggaaata tcaatacgaa 227940 catccataat cagtaacaaa aaataattga gttgattgtg gagcttttca ttgaagtcag 228000 aatactggaa ttatgataaa ctaatcgact atagataaaa attatccatc tatctatttt 228060 gtgtacgtag agttctgatg cttgtaaatt cttcaaggga gcaaaatgga catattcaca 228120 agaaatataa aagaatattt cctctattaa agaaaagttt tgacatttct ccctgtacta 228180 tatttacaaa gcaaatgcaa attattaagg attaaaaaaa gttttaaaat agaaactact 228240 atcatatgag tgtatattaa atcctttgct acaaaagaga atatgcatat tctaaaacag 228300 attggaagat taaaatattt accactgtag aaagcaaatt tagatttagg gaagtagaga 228360 tcttattgac cgaaattatt gtagtaggaa gaatgtttca actacaggat ctgaaaatgt 228420 ccaaaagtca cacagaaaaa aactcttctt ttatatggag gggtaaagta gcctagaaag 228480 aataaggtat ggggcagtgg ttgagcatgt catgatctac agttattcaa cgaatgattt 228540 atctgaagct cagcctgctc ttgacagggg ttgttaagga gaagttgttt catattacct 228600 tgcccaagag tggtccaaag ttgaggaact tgaaggaagg aatgaagctt aacttaaagg 228660 gtgataaagt caaaataaca atcacatttc atatcgatca gtggggcaaa aatctcagga 228720 acccttgata agacaaaaaa tgggaatttg atgggtctat atctggcttt tttctgtgta 228780 aacaggggac tctcattaaa tttaatgaag tcccacagga aaatatgctt ctttgcagta 228840 agctgttacc aaggaaacaa aggtttgggg gataaagttc cttaaacttt gcaattttcc 228900 aggattatac agttggagta aatttcaaca ttgtcactaa aaaaaaatcc ttgtctagac 228960 ctatgttttg aagcattttc tctatgttat tctccagtat ttcatagttt cagatcctaa 229020 atttaagtcc ttaatctatt tgagttgatt tttgcatgtg gtgagagaga gagagagaga 229080 tctagtttcc ttctttgtca cgtggatatc aagttttccc agaacaattt attggggaga 229140 cagctttttc tccagtagat attcttggtg cttttgttga caattagttc atggtaaata 229200 tctggattta tttctgggtt ctttattttg ctccactggt ctatgtattc gtttttatgc 229260 cagtattatg ctgtgttagt tactatagct ttgtactatg tttttaagtc agatagtgtg 229320 attcctttag ctttgttctt tttgctcaag gctgttgtgg ctatgtgggt ttttttcaaa 229380 ctaaaagctt ctgtaaagca aataaaacaa tcaagagtga agagacaaca tatagaatga 229440 gagaaaatat aaacaaataa tatgttttat aagagatcta tatccaaaat atataaggaa 229500 cttctataat gcaacaataa aaaacaagca acccagttca aaaaataaaa ataaaataaa 229560 gaacttgaat agacatctat taagagatac aaaagatata caaatagaca ataagcccat 229620 gaaaagatgc tcaacatcat taatcattag gaaaatgcat atcaaaacca cagtgagata 229680 ccacttcact accattagaa tgatgatatg ggttggctct gtgtccccac ctaaatctca 229740 tgttgaatgt aatttccagt gttggaggag gggcctggtg agaggtgatt gaatcatggg 229800 agtgaacttc ccccttgctg ttctcatgat agagttctca caagatgtgt tttttttttt 229860 aaatgtgttg cacctcctgc cacccctacc ctgctggcca tataaagatg tactggctgc 229920 ctctttactt tccaccatga ttgtaagttt cctgaggcct ccccagaagc agaaacctgt 229980 tcagcccata gaactgtaag ccgattgaat ctctttcctc tataaattac tctgtctcag 230040 gtagttcttt ctagcaatgt aagaatgaac taatacagat gactattaca aaaacaaaag 230100 caaaagtaaa acagaagtaa taagcgttag caaggatgcg gagaaattgg aattcttgca 230160 cattgctggt gagaatgtaa aatggcatag ccactgtgaa aaacagcatg gcaattccaa 230220 aaaacaacaa aaaaacaaaa caaaaaaatt atcgtaacca tatgatccag taattccact 230280 tctgggtggc aggttctagt ttcaatcacc tcttacctaa gggcaagggc actatgcatt 230340 cctgacaaca tatgtgagca tcctcttccc tgtccagcag cacattctct tggttatatc 230400 tttcctagat ctattctgat cctaattctc tccactaagt cacttcatag aggagagaaa 230460 taacaagtat tccataggcc aactccatta ctacaggaca gaatttttca ttctggactt 230520 caccaggcct gcctgtcttc agcacagtgc tcagcctgaa atgaaggcct caacagatat 230580 tggtataccc atgttcattg tttacaatag ccaaaagttg gaagcagccc atatgtctac 230640 taatggatta gtgggtaaac ataacgtggt acataaatat agatggacta ctattcagct 230700 ttaaaaggaa ggaaattcag acacatacta caatatggat aaacattatg ctaaatgaaa 230760 caaaccagtc acaaaaggac aaatactgca tgattcaaac ccatatgtga tattcaatgt 230820 agtcaaattt atagagagaa aagtagaatg gtatttgcca ggagctgggt gatagggaga 230880 aacagagagt taatgtgagt agtttaagct ttgcaagact aaaatgttct gtgggttgat 230940 gatggtaatg gtttcacagc aatgtgaaag tacttaatgc tggtgaaatg gctaaaatag 231000 taaattttat attatgtata ttttaccata agttggacaa aataaatttt tttttgaaaa 231060 ccaaaactga caaatttttt tcatgtttga ttgggggaaa aagatacaaa tagtaccttt 231120 attatataag aaaggagata taaatttaaa tactgtggaa tttttaaaac atgaaagatt 231180 atcatataaa atgacattac aacatttgaa aatacaggtg aaacagataa agaaaaatga 231240 ttaaaattca cttaagaatg tatgaaagct ctgagtaggc taatatgctt tagagaattg 231300 aatatgtagt aaacatcact aagtaaagaa aaaacctgca taggtttgtg agtaaattaa 231360 aaatttaaag caaagaaagc aaatatattg acaaaaatgc tttcagcaca caaataagtt 231420 cttattataa aacattttat aaacctaaaa atactttttc attaaacata ttttctagct 231480 cagtttacaa gtctcgcatt tttataaaaa aatgaacaaa agtagcacac aaaatgtaac 231540 tgtgaggtta atttgtttta aagggttata atgaagaaat tatatgataa tatcaagaca 231600 cacccaagct attattaata aattctcatt aaaatataaa aatcaaaaag agactgctgg 231660 caagatggcc aaaaaggaac agctctggca gctccagcga gaccaatgca gatggcaggt 231720 gattgctgcg tttccaactg aggtaaccta ttcatctcat tggaacttgt taggcagtgg 231780 gtgcagcaca cggaaggcaa gcagaagcag ggtggggcat tgcctcatct aggaagtgca 231840 aagagaggga ggcatccctc ccccagccaa gagaagccat gagggactgt gctattcagc 231900 ccagatacta tgcttttccc acagtattta ccacagacca ggagattccc tcatgtgcct 231960 acaccatcag ggccctgggt ttcaagcaca gaactggaaa actgtttggg ctgacactga 232020 gctagctgca ggtttttatt attattgttg ttattttttc ataacccagt ggtgcctgga 232080 acctcagtga gacagaatca tttattcccg tggaaagggg actgaagcta gggagccaag 232140 tggtctcact cagggggtcc cactcccaaa aagcccagca agctaagaac cactggcttg 232200 aaattctcac aggaagcaca gcagtctgaa gttgacctgg gatgatcgag cttggttggg 232260 ggagaggttt ctgccattat ggaggcttga gtaggtggtt ttcccctgac aggactaaaa 232320 aggcctggaa gctcagactg ggcagaattc aacatggtgt ggcaaagcgg ctatggccag 232380 actgcctctc tagattcctc ttcacttggc aagacatctc tgaaagaaag gcagcagctc 232440 caatcagggg cctatagata ccactcccat ctcactggga cagagcgcct gggggaaggg 232500 gtggctgtag gcacaacttc agtggactta aatgttcctg cctgctgact ctgaagagag 232560 cagcagatcc tgacaaggag ggtttttctc agtacagcgt ttgagctcta ctaagggaca 232620 gacttccttc tcaattgggt ccctgaccgc caaacctcct gactggaaga gacctcccaa 232680 caggggttgt cagagacttc atacaggaga gctctggctg gcatcagcct ttgcgtcaaa 232740 gcttccagag gaaggagcag gcagcaatct ttgctgttct gcagcctcca ccactggtga 232800 tatccaggca aatagggtct ggagtggacc tccagcaaac tgcagcagac ctgcagaaga 232860 ggggcctgac tgttagaagg aaaacaaaca aacagaaagc aataaaatca acatcaacaa 232920 aagaaccccc aaaaagaaac cccatccaat ggtcttcagc ctcaaatacc aaaggtagat 232980 aaatccatga agatgaggaa aaatcactgg aaaaatgctg aaaatttaaa gaaccagaat 233040 acctgttttc gtccaaatga ttgcaactcc tctccagcaa gggcacaaaa ctggacaaga 233100 aatattttga ttaattgaca gaagtaggct tctgagctaa aggagcatgt tctaacccaa 233160 tgcaaggaag ctaagaacct tgacaaaagt tacaggaact gctaactaga ataaccagtt 233220 tagagaacaa aataaatgac ctgatggagc tgaaaaacac agcacaagaa cttcctgaag 233280 catacacaag tattaatagc caaaatgatc aagcagaaga aaagatttca gggattgaag 233340 atcaacttaa taaaataagg agtgaagaca agattagaga aaaaagattg aaaaggaaca 233400 aacaaagcct ccaagaaata tgggactatg taaaaagact aaacctacga tagattgggg 233460 tccctgaaag tgagaagaag aatggaacca agttggaaaa cgcacttcag gatattatcc 233520 agaacttccc caacctagca agaaaggcca acatttaaat tcaggaaatt cagagaacac 233580 cactaagata ctcctcgaga aaagcaacct caagacacat aatcatcaga ttcttcaagg 233640 ttgaaacaaa ggaaaaaatg ttaagggcag tcagagagaa aggtcaggtt acctacaaag 233700 agaagccagt cagactaata gtggatctct ctgcagaaac cctacaagac agaagagagt 233760 gggaaccaat attcaatatt cttaaagaat tttcaaccca gaatttcata tcaagccaac 233820 taagtttcct aagtgaagga gaaataaaat tctttacaga caagcaaacg gtgaaggatt 233880 ttgtcaccac caggcctgtc ttacaagagc tcttgaagga gcactaaata tggaaaggaa 233940 aaactggtac cagcaactgc agaaaaaaca aaaaacaaac aaacagaaca ccaaaatata 234000 aagaccaatg acactatgaa gaaactgcat caactaacag gcaaaataac aagctagcat 234060 cataatgaca ggatcaaatt cacacataac aatattaacc ttaaatgtaa atgggctaaa 234120 tgccccaatt aaaatacaca gactagcaaa ttagataaag aatcaagaac catcggtgtg 234180 ctgtattcag gagacccatc tcacatgcaa agacatacat aagctcaaaa taaagggatg 234240 gaggaatatt taccaagcaa atggaaagca aaaaaaaaaa aaaaaaaaag caggggttgc 234300 aatcctagtc tctgataaaa cagactttaa accaacaaag atcaaaaaac acaaagaagg 234360 gcattacata atggtaaagg gatcaatgaa actagaagtg ctaactatcc taaacatata 234420 ttcacccatt acagtaggat ccagattcat aaaacaaggt cttagagacc tacaaagaga 234480 cttagacttc cacacaataa aagtgggaga ctttaacacc ccactgtcaa tattagacaa 234540 atcaacgaga cagaaaatta acaaggatat tcaggaattg aactcagttc tggaccaagc 234600 agacctaata gacttctaca gaagtcttca ccccatatca acataatata ccttcttcct 234660 gcaccaaatc acactattct aatattgacc acataattgg aagtaaaaca ctcctctgca 234720 aatgcaaaaa gaacagaaat cacatcaagc agcctctcag accacagtgc aatcaaatta 234780 gaactcagta ttaagaaaca cactcaaaac cacacaacta catggaaatt gagcaacttg 234840 ctcctgaatg actactgggt aaataacaaa attaaggcag gaataacaaa ttttttgaaa 234900 ccaatgagaa caaagagaca atgtaccata atctctggga cacagctaaa gcaatattaa 234960 gagggaaatt tatagcacta aacacccaca tcagaaagtg agaaagatct aaaattgaca 235020 ccctaacatc acaattaaaa caactagaga agcaagagca aacaaattcg aaagctagca 235080 gaagacacga aataattaag atcagagcag aactgaaaga gatagagaca cgaaaaactg 235140 ttaaaataga tcagtgaatc caggagctgg gtttttgaaa agattaacaa aatagataga 235200 ctgctggcca gacttataag gaataaaaga gagaagaatc aaatagacac aataaaaaat 235260 gataaaggag agatcaccaa tgatcccaca gaaatacaaa ctactatcag agaatactat 235320 aaacacctct acacaaataa actagaaaat ctaaaagaaa tcgataaatt tctggacata 235380 cacaccctcc caagactaaa ctaggaagag gtcatattcc tgaaaagacc aataacatgt 235440 tctgaaattg aggcagtaat taatagccga ttataaaaaa aaagcccagg accagatgaa 235500 ttcacagcag aaatctacct gaattataaa gaagagctgg taccattcct tctgaaacta 235560 ttacaaacaa tagaaaaaga aggactcatc cataactcat tttatgaggc cagtatcatc 235620 ctgattccaa aactgggcag aaacttcata caaatatccc tgatgaacat cagtgcgaaa 235680 atcctcaata aattactggc aaacagaatc cagcagcaca tcaaagagct tatccaccat 235740 gattaagaca gtttcatccc tgggatgcaa ggctggttca acatatgcaa attggtaaac 235800 gtaatccatc acttaacaca accaatgaca aaaaccacat gattttctca atatatgcag 235860 aaaaggcctt caataaaatt caacattcct tcatgctaaa aactctcgat aaactaggta 235920 ttgatggaac acatctcaaa ataataagag ctacttatga caaacccata gccaatgcca 235980 tactgcatgg acaaaagctg gaagcatttc ctttgaaaac cggcacaaga taaggatgcc 236040 ctctctcacc actcctattc aacatagcat tggaaattct ggccacagcc atcaggcaag 236100 agaaagaaat aaagggtatt caaataggaa gagaggaagt gaaattgttt ctgtttgtag 236160 acaacatgaa tgtatattta gaaaattcca ttgtctcagc cccaaagttc cttaagctga 236220 taaacaattg cagcaaagtc tcaggataca aaaccaatgt gccaaaatca caagtaatcc 236280 tatacaccac taatagacaa gcagagagca aaatcatgag tgaactcctg ttcataattg 236340 cttcaaagaa aataaaatat ctaggaatac aacttacaag agatgtgaag gacctcttca 236400 aggagaacta tgagccactg ctcaaggaaa taagagagga cacaaacaaa tggaaaaaaa 236460 gttccatgct tatgtgtagg aagaatcaat attgtgaaaa gtataagtaa tttataggtt 236520 caatgttatt cccatcaagc taccattgat tttcttgaca gaactagaaa aatctacttc 236580 aaatttcata tggaaccaaa taagagccca tatagccaag aaaatcctaa gcaaaaataa 236640 caagctggag gcatcacgct acctgatttt aaactatact acaaggctac agtaaccaaa 236700 acagcatgat actggtacca aaacagagat atagaccaat ggaacagaat agaggcctca 236760 gaaataacac cagacatcta caaccatctg atctttgaca aacctaacaa aaacaaggaa 236820 tggggaaagg attctctatt taataagtca ttctaggaaa actggctagc catatgcaga 236880 aaccagaaac tggacccttt ccttatacct tatacaaaaa ttaactcaag atggattaaa 236940 gacttaaatg taaaacctaa cactataaaa accctagaag aaaacctagg caataccatt 237000 caggacatag gcacggacaa agacttcatg aacaaaacac caaaagcaat tgcaacaaaa 237060 tccaaaattg acaaatgtga tttaattaaa ttaaagagct ttgctcagca aaagaaacta 237120 tgatcagagt gaagaggcaa cctacagaat gaaagaaaat ttttgcaatc tatccctctg 237180 acaaaggtct aatatcctga atctacaagg aactaaaaca aatttacaag aaaaaaacaa 237240 acaagcccat caaaaagtga gcaaagtata tgaacagaca cttctcaaag aaagacattt 237300 atatggccaa gcaaacatga aaaaaagctc accatcactg gtcgttagag aaatgcagac 237360 caaatccaca gtgagatacc atctcacacc agttaaaatg acaatcatta aaaagtctgg 237420 aaacaacaga tgctggcaag gatgaggaga aataggaatg cctttacact gttggtggga 237480 gtgtaaatta gttcaactat tgtgagagac agtgttgcaa ttcctcaagg atccagaagc 237540 agaaatacca tttgatccaa caatcacatt actgggtata taccaaagga ttataaatca 237600 ttctactata aagacacgta cacatgtatg tttactgaag cactatttac aatagcaaag 237660 acttggaacc aacaaaatgc ccatcaatga tagactggat aaagaaaatg tggcacacat 237720 acaccatgga atactatgca gccatgaaaa actgagttca tgtcctttgc agggacttgg 237780 atgaagtggg aaaccatcat cctcagcaaa ctaacacagg aatagaaaac caaacaccac 237840 atgttcttac tcgtaagtgg gagttgatca atgagaacac acggacacag ggagggtaat 237900 atcacacact ggggcctgtc agggggtgaa gaacaaaggg atggagagca ttaggacaaa 237960 tgcctaatgc atgtggggct taaaacctag atgacaggtt gataggtgca gcacaccacc 238020 acgacacatg tatatgtatg taacaaactt gcacattcag cacatgtatc ccagaactta 238080 aagtaaaatt aaaaaaatta aaaataagaa agcaaaaaac aaaaagatac tcactgttat 238140 atttttaaat atgaatgaaa aatataacat tctctaattg caagggttgt ttatcatgta 238200 tcattttaat gacttaacaa gattagcatc ccatttagaa ttaagaataa gaaagaatat 238260 tgaagaagat aggaaaagtt atttgcagat gatacgaatg tctattcaaa caaatctagg 238320 aggatcttca tgttattaaa attaataatt tgtttcagca acgtggccaa aatataagaa 238380 taaaaacgta aaaagcaatg tatgttttaa agtctgatca gaaaccaatt tgaatttttt 238440 tcttgaggta catttgcagt agaaacagag atattaaata tctaggaatt atttatagat 238500 gagatagctg tacatataga tatagacata tacatacaca gaataaaagc ttttcacttt 238560 aagacttcaa tgtcctttaa aagaacaaaa atatgtctag tttcagactt ttctgaaata 238620 caaaatgtta taagacagaa aagcaatttg taatggtgtt tacaagatca gatttttact 238680 gaaaatttta atataacact tacttattat taaaataatt taatgacctc ttcaaaaata 238740 tacatggcta ttgcctaagc catacactct tctaccttta aaaaatcact taaaaacata 238800 ctccaaccag ttgaaagttg aatccagtta atttctcaaa gactgcttag ttaatttata 238860 taattatttg cctttgaaat tttcttaata tctttttaga atgtttatgt aaacacttac 238920 aatccaaacg gaagtagtag tacacttaaa acacctgaag caagttcagt gatgcaatta 238980 tacatgagaa tgcttagaaa attccattca aaatcctcag tgcaagttaa tcctccggaa 239040 tttgtacaaa gataaaatta gcactatcac actaatgatg tacaaaaaat atttcctttc 239100 tttggagtca tatgactagc tacattttat ttgcatttac tattaataaa tgacggttct 239160 tctgctcagc atggttaatt gactggatgc acagtactca tcccctgtta tcagtacaga 239220 agtgaggata aatgaaaagg aaggaaggga gggaattagc caaagtgatg aatgacacat 239280 gaatccaagg ggaattggaa cctgatgatg gctttgatac ctacctagga agagggcact 239340 tgactttagg ttccatggct ttgggtagct ataactgagt tatattcgta aggttagaag 239400 tcacaaagtt ctacctcatc tctgaaacaa gttctgagaa aaaagtctac caaacagcac 239460 taggaagtcc caggaatact ttccaactcc caggaacgat ggctggaaat tgtatcacac 239520 acaaaatatc aggagcccag gcctacagct ttcacactta taaagtaaat ttatactatt 239580 ggcatggtga atgaatatca agataattaa tgtccacatt ttttgctcac attgcttctt 239640 aatcttcctc tttcctccta aaattacatt aaaattgttc tgcaactggg aaaccagaag 239700 gctgaatcat ttttggaaca acagcaagca tgcccactac aggccaggca catcaaggaa 239760 cctcactggg ggaactcaca ggaataaaat tataaatcaa aggaaaacac aaaacattat 239820 aacacctttt aaaaatattc aataaaaatt gtaccttata actgaagata aaaccactta 239880 ggcaatttta aataagtgta tttaaagtgc tcaatgatac agtggaagga tatgaaatta 239940 cgaagaaaag aacagtgtga aaaaaaagtc aaccagaaaa agaaattttt ttcaaataaa 240000 tgcaaataaa attatagaca ttgaaaatat aatcactcaa attaaaaaaa tctcagtgga 240060 tggattaata tctaagaaag aattagtaga tttgaagaga gatctgaggc aatcacccag 240120 aattaacaca gaggaatatt tagagatgaa agatactgat aagaatttag gagatgggaa 240180 agataagtag aaaataacca tcatgcataa agtagggttt ccaggaacat actattatca 240240 ataatgagga aataacattt gaaaacaaaa tgctttcaaa ttttctaaaa ttgcagtgtc 240300 atataggagg aagtctctgg gtcctgataa gctaattcca catcttggct atcaaatgat 240360 ggtacagaac ttgaaaagca atgaaagacc tcttaaaagc ttcttaaaag aaaacaccat 240420 acataaaagg aagaagaaaa tgtgattcac atttttcagc aacaatgtat aagagaagac 240480 attgaaacat cagcctcaaa gttctgacgg gaaaaaaaaa atacccgacc catgactcta 240540 tatctaatgg aaactatatt aaacactgtg tctacaatag gaatattttc agaaatagga 240600 atgaaagaaa atttactaat cggatgcttt acaaaatgta aattgacttg actcacatgt 240660 cttaaacatc tcccaatttt aataaaaatt aagtaaatct aaattcttaa ttaagttttc 240720 ataatttatt gtgtcctaga tggctggtta atttaagttt aagaaatctt tatttatcaa 240780 ctatcaaata tcaaggagtg tacagcatac aaagaaggga ttaaaaaacc atatgagttt 240840 aatgccctga aagaagacca ctacaaataa cagctaaatt ttttgttggc ttaactatgt 240900 atgccaggca cttagagtta catttacttt agagttatgc ataaaacttt cttgaggtag 240960 ctattatttt acagataatg aaactgaagt tgaaagtggt taaaaacttg tataaagctg 241020 ttaagaatag agacagaatt ctaaaattct aagtaatttt ccctcatgct gttttccatt 241080 ataattcatt gttttttcat gatgctttga atttataagt tatttatgaa agtttaagcc 241140 ttcattcata tgatgaccct gataatatag agaaatagaa gagttctcta attcattgat 241200 gtggaaaata caagaaaaag caataaggag ttttaccaaa gtcacagtgg gcctcctata 241260 aagttggaat aaaaattcat atttcaagaa attcccatat gggagcttat ttttacagta 241320 gaccagagtg gtaccttaga attaagagca cccgttgctc acctgtgtgc attgcacaac 241380 tcttagcatc attgtgcctt gacttggcca cttgtagagg ctcagtttga aagaatacat 241440 gaatggacca gtcatcccgt caccaacgtt tctttctttt tctttttttt ttctgtactc 241500 gagttgctta aattttcttt tatatatata tatatatatt ttttttatta tactttaagt 241560 tctaaggtac atgtgcacaa tgtgcaggtt tgttacctat gtatacatgt gccatgttgg 241620 tgtgctgcac ccattaactc atcatttaca ttaggcatat ctcctaatgc tatccctccc 241680 tcaaccctcc tccccacaac aggccccagt gtgtgatgtt ccccttcctg tgtccaagtg 241740 ttctcattgt tcaattccca cctatgagtg agaacatgcg gtgtttgctt ttttgtcctt 241800 gcgatagctt gctgagaatg gtggtttcca gcttcatcca tgtccttaca aaggacatga 241860 actcatcatt ttttatggct gcatagtatt ccatggtgta tatgtgccac atttcttaat 241920 ccattctatc attgatggac atttggattg gttccaagtt ttgctattgt gagtagtgct 241980 gcaataaaca tacatgtgca tgtgtcttta tagcaacatg atttatattc ctttgggtgt 242040 acacccaata atgggatggc tggatcaaat ggtatttcta gttctagatc cctgaggaat 242100 tgccacactg tcttccacaa tggttgaact agtttacagt cccaccaatg gtgtaaaagt 242160 gttcctattt ctccacatcc tcttcagcac ctgttgtttc ctgacttttt aatgatttcc 242220 attctaactg gtgtgagatg atatctcatt gtggttttga tttgcatttc tctgatggcc 242280 agtgatgatg agcatttttt catgtgtctg ttggctgcat aaatgtcttc ttttgagaag 242340 tgtctgttca tatcctttgc ccactttttg attttttttt ttcttgtaag tttgtctggg 242400 ttctttgtag attctggata ttagcccttt gtcagataag tagatttcaa aaattttctc 242460 ccattctgta ggttgcctgt tcactctgat ggtagtttct tttgctgtgc agaagctctt 242520 tagtttattt agatcccatt tgtcaatttt gtcttttgct gccattgctt ttggtgtttt 242580 agacatgaag tccttgccca tgcctatgcc ctgaatggta atgcctaagt tttcttctag 242640 ggtttttatg gttttaggtc taacgtttac atccttaatc catcttgaat tgatttttgt 242700 ataaggtgta aggaagggat ccagtttcag ctttctatat taggaaaaga ggaagtcaaa 242760 ttgtccctgt ttgccgacga catgattgta tatctagaaa accccattgt ctcagcccaa 242820 aatctcctta agctaataag caacttcagc aacgtctcag gatacaaaat caatgtacaa 242880 aaatcacaag cattcttata caccaacaac agacaaacag agagccaaat catgagtgaa 242940 ctcccattca caattgcttc aaagagaata aaatacctag gaatccaact tacaagggat 243000 gtgaaggacc tcttcaagga gaactacaaa ccactgctca aggaaataaa agaggataca 243060 aacaaatgga agaacattcc atgctcacgg gtaggaagaa tcaatatcgt gaaaatggcc 243120 atactgccca aggtaattta cagattcaat gccatcccca tcaagctacc aatgcctttc 243180 ttcacagaat tggaaaaaac tactttaaag ttcatatgga accaaaaaag agcccgcatc 243240 gccaagtcaa tcctaagcca aaagaacaaa gctggaggca tcacactacc tgacttcaaa 243300 ctatactaca aagctacagt aaccaaaaca gcatggtact ggtaccaaaa cagagatata 243360 gatcaatgga acagaacaga gccctcagaa ataatgccgc atatctacaa ctatctgatc 243420 tttgacaaac ctgagaaaaa caagcaatgg ggaaaggatt ccctatttaa taaatggtgc 243480 tgggaaaact ggctagccat atgtagaaag ctgaaactgc aaagacaaaa gccacatgat 243540 tatctcaata gatgcagaaa aagcctttga caaaattcaa caacgcttca tgctaaaaac 243600 tctcaataaa ttaggtattg atgggacgta tttcaaaata ataagagcta tctatgacaa 243660 acccacagcc aatatcatac tgaatgggca aaaactggaa gcattccctt tgaaaactgg 243720 cacaggacag ggatgccctc tctcaccact cctattcaac atagtgttgg aagttctggc 243780 cagggcaatt tggcaggaga aggaaataaa gggtattcaa ttaggttttt aaaatatttt 243840 tgagacttgt tgtgtggtcc aacgtgtcat cagtcctgga gaacgttctg tgtgctgatg 243900 aaaagactgt gtgttcttca gctgttgggt gaaatgttct gtaaatgtct gatgggtcaa 243960 tttggtctat ggtgcacttt aaatccaatg tttctttgtt gactttttgt ctcgatagat 244020 gatctgtcca atgctaaaag taagctattt aagcccccaa ctattattgt attggaacct 244080 atctctgctt ttatatctag taatatttgc cttatatatc ttggtgtcct gttattgggt 244140 gcatataaag taatattgtt acattctctt actgaatcaa tctctttatc attatataat 244200 gttctttttt gtctcttttt atagttttga acttaaagtc tatttcatct catgtaagtc 244260 tagctatttg ggctcacctt tgaattacgt ttgtgtggat tgtctttttc cattccttcc 244320 gttttagtct atgtgtgtct ttacagagga aatgagcttc ttgtagacag catttagttg 244380 agaaatccaa ggcaatgaga tatcatctcg cttgagttaa aaatgtctat tttcaaaaag 244440 aaaaaaatag caaatactgg caaatatgtg gaaaaaggga actccaattt gctgttggta 244500 ggaaggtaaa tgagtacagc tattatggag aacagtatgg gagttcctca aaaaactaca 244560 ggtagaacca ctatatgatc cagcaatccc actacagggt acatatctaa aggaaaagaa 244620 aacagtagat aaaagggtta cttgcaccct cgtgtgtact gcagcattat tcacaagagc 244680 aaaaatatgg aatcaccata agtgttcatc aaaagacaaa tgatgcaaaa tgtggtatat 244740 atacacaatt gaatattatt cagccataaa aagaatgaaa tcttgaaatt tgcggcaacg 244800 taaatgagca tggaagacat tatattaggt gaagtaagac aaacagaaag acaaatacca 244860 cattttctca ctcatatgta ggaactaaaa aattaatgtt atagtagagt gttgaatagt 244920 ggttaccaga gggtaagatg gacaggagag atggagaaat aaggagaggt taggtaatgg 244980 gtaaaatatt acagttagac aagagaaata agttcgagtg ttctacacca cagtaggatg 245040 actatagtta acagtaattt actatatatt ttcaaatagc tagaagaaag aattttgaat 245100 atttgcaaca taaagaaagg ttaagtattt aaggtcatag gtatgataat agccctgatt 245160 tgattattaa atattatatg tattaaaata tcacaatata cccataaata tgtacaatta 245220 ttatgcatca attaagaaaa gaaggaaaaa tctaagggaa aacaaaattg aggtggtaaa 245280 taatatatta aattttttgt gtatataatt ttaaaggaaa atgatttcag ggtgtgtata 245340 cataaaatat cacttggtat actttaaatg tgtgcagttt atgtatgtca attacacctc 245400 aataaatctg tcaaaaatgt gtgaccataa taatctaagc caaaattgta gatgaagacc 245460 atgcagcagt agaattgggt ggagaagtcg agaaggagaa caaattattg ggaaagagaa 245520 gacataaata acatagacat caatataagt atgaaagaaa taataaagca tgaatttaat 245580 taatataacc aacagttaaa tgaaaatgaa agattatttt caaaacagta gaagaaaatt 245640 tgatatgcac attggaatat aagaaaggag gggaaagaaa aactataaca aagcaaaaaa 245700 gaataaacac agattaaaat ggcaaattaa aataataata ttagctataa taaatataaa 245760 tgacagatag aaaaagaaaa caggatcagg cagaagggct ccagaggagg actaatctcc 245820 cacagaattc cagaaacacc tgctgtcagc aatgagtctt tgtagggtgc tcaggtagcc 245880 aatcagacag ttctttcttt catataattg caccacacgg ctggcacccc atctctgatc 245940 acacctgggg aggtgcatag tgagctgaca gtacagactg aggccagaga tctggtgcac 246000 cacactgcca aaatcccagt ccgtttccca gacccatcct ctggagcttg gtgttgtctt 246060 ctgctggcat ctgtgctata ccacatgtag gtcattaggg caataacatg gctattgctg 246120 tttctgtctc tgagattcca agaaatgtga atcaatacct ggttattaca ctttgtttgc 246180 gccatgacat ctctaataga aatatgtaaa gtgaaaagtt agtaaaaaga gattaatatt 246240 tcagtaatag gatgaactag caattctaaa tgattctcca ccagtagaaa aactgtatgt 246300 actgggtaaa taattacagc caaggtttta aatgaatcat tggcttcaca agaaggtatg 246360 ataaatctct aagatttaga ggtgaaaagg aagaataaat taaggaagag tgaacataaa 246420 ttcagaagaa aatattgccc tgggaatcta ttgcagggat tggaccagat tgttagagta 246480 gctctatcca cattggacag atatagtcac acttccttac acatctgcca tctccatgag 246540 gggaacaggc cctgactagc ctgctgttcc aaagaggatg agagatgcat aggacaccct 246600 tggatatgat ctggagcttg gcgtcaagcc aagcagacca gcctagatca gcttctcact 246660 tggtccattt ttgtcttctc aggtttatcc caataaattt tttgcatgta attgtctgag 246720 agcctcaata agtctagatc agccaacccc aagacacatg ctttttgatt caagccactg 246780 agttttggag tggtttgtca catatcttta ttgtggcaat tgctaaccaa tatgttactt 246840 ttaaaactgt agctggagtc tcttggtagc aactatgttt acaggatttg attgagaagt 246900 aatcatcctt gcttctcaag aactagaata tgagttgtgg agacatgagg tgcttctcag 246960 tttgggatgt agaaagaaag aactgtgatc tggtggaagc aaagcagaaa aggcagcaga 247020 gagggagcct tcaggagggt gttaagcctg tcagtgtgtg atgggtaata cttgtgctat 247080 ggactgagcg tttgtgtccc tataattcac atgtggaagc ctaaaccccc agtgtggcta 247140 tattttgaga tgggacctct aaggaagtaa ttaaggttaa atgaggccat atgagaggga 247200 ctctgattca ataggataaa aagagatatc agagagttca ttctctctct cttcatgaac 247260 atgcactgag gaaaggccat gagaggacac aacaagagcg gggccatcta caaaccagga 247320 agagagcctc accagaaaat gaattgtcca gagcatggtt cttcaacttc tagcatccag 247380 aactgtgaat ggatctattt ctcttgttta agccacccac tctgggtatt ttcttatggc 247440 agcttgaact gactgagaca atggggatct actcagttct ctgcttcagc ttcaacttac 247500 tcacagctac agagaatagt gctgctttag gctcacagcc tctcccagga tattaccttc 247560 tgtcactgat atggtttggc tgtatcccca cccaaatctc atcttgaatt ataactccca 247620 catgttatgg gagaaaccca gtgggaggtg atttattatg ggggcaggtc tttcctgcac 247680 tgttctgatg atagggaatg agtctcaaat gatctgatgg ttttaaaaat ggaaatttcc 247740 ctgcacgagc tctctttttg cctgctgcca tccatgtaag acatgacttg cccctccttg 247800 ccttctgcca tgattgtgag gcttccccag tcatgtggaa ctgtaagtcc attaaaccct 247860 gttttgtgaa ttgcccagtc tctggggtct ttatcagcag tgtgaaaatg cactaataca 247920 gtgtattggt accagtagag tagggtgctg ctaaaaaata ctctaaaatg tggaaacgac 247980 tttggaactg ggtaacaggc agaggttgga acagtttgga ggggtcagta gaagacagga 248040 aactccagga aagtttggaa tttcctacag actttttaaa tagccttgac aaaaatgctg 248100 atagttatat gaacaagaag atccaggctg aggtaatttc agatggagaa gagaaacttg 248160 ttgggaactg gagcaaaggt gactctggct atgttttagc aaagagactg gcagtatttt 248220 gcccctgccc tagagatttg cagaactttg aacttgagag agatgattta gggtacctgg 248280 aggaagaaat ttctaagtag cgaagcattc aagaggtaag ttgggtgctg ttaaaagcat 248340 tgcattttaa aaggaaaact tagcattaaa gtttggaaaa tgtgcagcct aatgatgtag 248400 taaaaaagaa aaacccattt tcttaggaaa aatttaaact ggctgcagaa ttttgcataa 248460 gtaacaagga gtggaatgtt aatccccaag accgtgggga aaatgtccac agggcatgtc 248520 aagagacctt tgctgcagcc cctcccatta cagacccaaa agcttaagag gaaaaaatgg 248580 tgggccaggc ccagagtccc catgctgtgt gcaggctagg gacttggtac cctgcatccc 248640 agccactcca gccactgcta aaaggggcca aggtacatct tggcccatgg tttcagagag 248700 tgcaagcccc aaaacttggc agcttccatg tggtgttgag cctgcagatg cacagaagtt 248760 aagaactgag gtttgggaac ctctgcttag atttcagagg atgtatggaa atgcctggat 248820 gtccaggaat aaatttgctg caggggtggg gctctcatgg agaacctctg ctagggcagt 248880 gaagaaggga aatgtgagat cggcccccga cacagagtcc ctactgggca ccccctaatg 248940 aagctgtgag aagacagcca ctgtcctcca gatcccagaa tggtagatcc actgatagct 249000 tgcgctgtgt gcctggaaaa gctgtagacc ctcaatgcca gcctgtgaaa gcagccagaa 249060 gggaggctgt accatggtaa gccacagggg tggagttgcc caagaccatg ggaacccacc 249120 tcttgcatca gtgtgaactg aatgtgagac atggaatcaa aggagattat gttggagctt 249180 taaggtttga ctgccctgct ggattttgga catgcatttg gcctagagcc cctttgttct 249240 ggccaatttc tcccatttga aatggatgta tttactcaat gcatttaccc ccattgtatc 249300 taggaagtaa ctaacttgct tttgatttta cgggctcata ggcagaaggg ccttggcttg 249360 tctcaggtaa gaggttgaaa tgtggacttt tgagttaatg ctgaaatgag ttaagacttt 249420 ggaggactgt taagaaggca agattagttt tgaaatgtga ggacatgaga tttgagaggg 249480 gcctggggtg gaataatatg gtttggctgt gtcctcaccc aaatctcctc ttgaagtgta 249540 acttctacag ttcccatgtg tcatagaagg aacccagtgg aaagtgatcg aattatgggg 249600 gcgggtgttc cctacactgt tcttctgtta gagaatgagt ctcacaatat ctgatggttt 249660 taaaaatggg agttttcctg caaaagctct ctctctttgt ctgctgccat ccatgtaaga 249720 tgtgactggc tcctctttgc cttccaccat tattgtgagg ctaccccagc cacgtggaaa 249780 tgtaagttca ttaaatctct tttttttttt cataaattac ccagtctcag gtatgtcttt 249840 atcagcagtg tgaaatggac taatacagcc acagaaaatt atcttataca agaatgtgtc 249900 ttttctcagg gtgtggctta tagtcaagaa tatcaaagac cccggccttt cctgcaaatt 249960 ggaacaaggc taaacagtat ccaaggtgta gagctcccta tagaatcagc agagcttgca 250020 tttgcaagtg tattaataga tcagcttctc cttctgccca atcttgcctt cctcactttt 250080 tatttcagaa ggacatttac tagtacaatt tctgcatcta cttcttagtc tcagaatttg 250140 tttccagaga acccaatcac aggcagagtt tttgagtgat tttctgcatt gcactttcat 250200 tccaatagtt ctgttgtacc ctctcattaa ataatggaag cgtctgacta ctgtatattc 250260 aagggcaaag gatcatcccg tgttttgctt gaagtggtac aaagaaaaac agaaaacact 250320 tgagctttgc aagacttctg cctcagaaag aagtaggtag acaagtgtaa gctgggatga 250380 atttaagata tggaaccatt tactaggcaa cctgggggtg actgaggaga ttaacttgtg 250440 gtcaaaaaca aggattcttt cagtaacagt tgatgagcac ttgggcaatt gtaatttgac 250500 acaaaggaaa tcaagacttc caaggccagt aaattatgac atccacagga tatctttatt 250560 tatatccata catttgcaaa attgagattt ttctgcatat aaaaccttat gcattgcttt 250620 atttaacttc taaaaatatt ttaggttata aaataatttt cagagtatag cttttgatga 250680 ttgcataatt ttccatgctg gagatatact gtaaattatt taccctactt ctctattttt 250740 tgatatttat atggttttat ttttttctat tataaataat actgagttga ctatcattac 250800 acataaatct taatgtgtat ttctgattac tttcttggga taaacctatc gaagtggatt 250860 taatgactat tttcagtaat aaaaagaaag attattttga aagcttgtga tacatattgc 250920 agaaccttga tctgtaagtg tgaaatatgc actccttcca gcctttcaat cagtatatgt 250980 ttattgactt gtacgatgta agcagaactc tttttagatg ttagagaaaa gaaacaggta 251040 gagtcttgtt ctcagggttt tcatgttcaa tacaacacaa cacaaagttt tgtgtatgtg 251100 tatacataat gtgcaattgc ctatgtaagt cctcattatt ttatcaactg tagcaggcat 251160 gatttaaagt atttttttta attttctggc atgctaacaa caaaaagttt atcaaggaaa 251220 catcattttc ttgcaaagca aggacagtat atttgatatg agctttttac cctgctctga 251280 taagaacata gaagatatgt tgctattgaa ctttcttctc cacatatatt tttagttact 251340 ttttatttca tattctgcag ttacacttcc tatacttcag catcagttta tattcaacta 251400 catctcaaac ttgaaatcct tacacttcct tcagaatctt cttacaaatt cctttcctgt 251460 ctttctaagt tatatgtacc ctccaggttt tcacctcata aaagggtaaa gaaaaaaaaa 251520 atagaaagca acatcttttg tttttacagc ataaggagtt cagctcctgg cagttcttct 251580 gccagcataa cagttgatga acactggaca gcctgtttca agtgagatgt aaaagaatca 251640 agactgtatc ttaactgttg tatctgattc ttttaataat tttcacccaa gtgaagggca 251700 tgtttgcagc agttatttgc atgagccgca tcatcagcac cccgaacatt agcatcctgg 251760 gcattactga agactcttgg tcctttccct gacgaacgat ggtgcatggc atgatctact 251820 ttttctataa agcctggaat gacatagctg tggcaaacac tctaggagga aaatataaat 251880 gtccttcttt tctgatattc tcattttcat cgagtaataa aggaagtgga aaggtagaag 251940 atacatgcaa aatcataaaa gtaattctaa ttcacaagat aatctatcat tttcaagcaa 252000 gtggaatata aatactgtag gttttagaga tatttagccc caaataaaac cacaggtcta 252060 cacatgagtc actgtagcac tttaacctct ctgggctcta tttccttctc tttaaaatgc 252120 acagagggtt tttgtgaaat cagtttagat tatgcatatg ccatttctaa aatagtgcct 252180 tctctactgt agttgttgaa taaaaaagta acaatattag agaaacaatt ttagattttt 252240 ctttcagtaa ataagcttac aaataaaata tctactttgg cttttatgat aaactttggt 252300 ttgaaattat ctgaaaagaa atccttagtg ttctcatgta ctactcttat tcctgtccat 252360 gaccgttttg aacagtgaaa gaggtcaata ttttctaaag agcctatgtt ttgacgactg 252420 tatatttgct tggcaatgtt ttatgaaata aataattagt aatggtttta gctatatttt 252480 aggtactcac tacaatactt tttttgttct acatttttct aaataccaaa taaagaatta 252540 gaaaatcatt caattatagg atgtgacctt atcttgctga ttacaccaaa tccaaagtca 252600 attttagcct ctctttcaga ggttgtaaat agaaacccaa attggataac acatttcccc 252660 ttcaagacaa acaggtggag cccatcattg aaagtaaatt atcaggtgag gactcaaggg 252720 acccgggcca gttcagattc tgtccagtca ttaaactttt tagatctcac tgtcttcatt 252780 tgtcaaaggc agatagcgac cctgacttca ctgatacaca gagttatcat gaaggctgcc 252840 tggtacaatg ggcagaaata tgctctaaca aagagatgta aatgcagtat gtatagcatt 252900 gagacttctt agaagggagc tcgctgctgc caatgctctg ctatgagttg cctcaggttg 252960 tacaattcct ggtgaaggcc tagaatttaa gccattgaat aggaggatta tttgggaacg 253020 atataaaatt ggagataggt taatctaggg tcaaatatag gtgagaagca aggaaataat 253080 actgtggtaa gaaaatagat taagcagaga aagattctat gattctgact gaaataagca 253140 ttgctaacta taactggttt ttgtgcccct tggagcatga ggttttgaag agctcattgt 253200 gttggactgc ctctttggag aaaccatcaa tggaccttca atctcatcaa tggaaatttt 253260 acccaaaaac acaaccttga tgcttcagaa gagaggagga gggaaggatc atgtgcccat 253320 gagttttacc cctttgatac gcagtagagt attgtttggc ttacaaagta tttgggggaa 253380 gatatgagca agtaagaata taagtgcctc atctctcaga tagatatgat ttgaggcatt 253440 agttgacatc ctacagaaga aatatttttt aaaaagtcca gcttcaacta ctggacccat 253500 catttatcag ctatttgact ttgggaaagc aacttatttt tctaaacttt atctctgaaa 253560 tgaaattaag gatactgtat ttgttatggt tctccagata aacagcagat agatagatag 253620 atagaaagat agatagatag atagatagat agatagattg atagatagat agatagatga 253680 gcaggagaga ttttaaggaa taggttgaaa agattacaga ggctgacaag tctgaaattt 253740 ataggccaaa ctggcagcct gaaaattcag gtaagagttg atattgatgt catagttttt 253800 agtgcgaaat ttgtagggca ggtcagcagg ttggaaactc aggtgagatt tctgtgttat 253860 agtcttgaaa cagaatttct tatttttcat gaaacctgag tttttgaact gaaggccttc 253920 aattgattgg atgaggccca ccctgcagca gatgttgcag ggtaatctgg cctattaaaa 253980 ctcagctgac catagtatta atcacatcca acaatacctg tatagcaaca tcgacaccag 254040 tgtttgatcg tacaactgag catcatagtc tagccaagtt gacacataga gtcaaacatc 254100 acagatactt acctgtggtt cagtgggata atggtctgaa cacttagcaa ggaagttgag 254160 atgatttcct gtgtcagcat tttatttaag tggctgaggg tgtgggagtg gcaggggata 254220 tatttcaaat atatcaagcc taaaatatct tcttgttgac tagataggaa tatgtgttac 254280 tttaatacat acaactttac tttatcttaa agatattgat gattcaggtc aaggacccag 254340 caaaaacaat gttgtgtaga aagaaagagc acaaaatttg agtgtgtgag aactgggttt 254400 gaatctaagt tatatcctct ctatcacttt gggaaatcta ctcttgtctt caatttcctt 254460 atctgtcaaa tgaatttaat aacaccactt ctttgagttt gggggatgtg tgaaacacat 254520 gaaacataga gtttctcaga aaatgtagtc taatatttgt aatgatcttt tttcttcatt 254580 tactgttttt tcaacctgct gagtagaagc tcatttttcc atctgagaaa tacattttca 254640 aattccacaa ctttcttgtc atttatggtt actaaaatca gttgaggtag tttataaatc 254700 caatcccata tcaattgtaa aatctttgtc tccttcttta ttggacaaaa ctgagggtca 254760 gagacttgga atggagtttg tgcatggctt tttctttcgc ttctttttct tcccactttt 254820 ggatcttgtt tcttcaagtt tgggacaagt gaagatctat catgagatgg taatggtcat 254880 atgcctcttg ggctgcttct gtgatgcaga agtgctcctg gcctgttcct gatgttccct 254940 gatatgtgag gcaatctgca gatatgttgg tttctgtatg gtgtgtatgc ttttcttgga 255000 gaggtgtcca gatttccaca gcatgcctct tattgatgac ccacttttag agacaaatgt 255060 gtttctttat tggttgcccc catcaaaaat ccatacctcc aacctctttc tagctgcaga 255120 cactgaggct attgaggtat tcttccttcc atatcttctg ggagctttag ggatgtggag 255180 tggggagatg cattttttca tactggttag ggctactctt gcaattctgc catattcaga 255240 taacatgtgg cagaaacagg cagacctctt taattacatt ccaaggggca caggcaccaa 255300 gttccccagg aactctttca ccctgcagtg ctcctgtgga agcaataaga gggtagcccg 255360 gcagatgtgt aatgcaatga acatgacctg gtaagccaaa attcaagctc tctttctttc 255420 aggaatatcc acctgacttg cttaaagctc tcatccccac cattccttgt cttcggggat 255480 gtgatggtga tggaagggaa tcacagggca agagcatagg gaaagtattt tgcactatga 255540 gtattctatt ccctaaaaga aagaagatgt ttaaaaatta cctctgtatt tcccctcttt 255600 cgttctttag ccatccatcc tatactccag gatgacaagt tatccagtgc cctgggagct 255660 gtatctgacc ccatttgatg gtcactctct tctgaataca ggctttaatt gtcaattaca 255720 aggcaactaa aaaaagtttc attccatatc ctaatacagt agctattatt attatcagca 255780 ggaacagtag ctcctttatt cacactgagc tcgtagcact ctgtttttct cctttatgac 255840 cattgtataa tggatgcttt ctggatggtg gcatattggg ccgtaaatac tgtaacttcc 255900 tcctacatag attaccagtt agagctcctt tacaatcatt ttatggtttt aaatatagcg 255960 ccatacttgc ttcaagatct tgtttcctgt ttcacaaaga gcgattggtc ttcctcgtgc 256020 tgagaaaaaa taacatttga aatgcagaat ccagcctgtt ccccagggct ggctttccac 256080 caggttcctg tggggaggtc aagcaggtat ttcagcaggg cagtgtcatg ttgctccata 256140 tcctggccac atctcccttt agactccaca tcccaatatc tgctgttcaa ttccctgggt 256200 aattaattac cctacaggag ccaatagaat cctgtataag ctggtgggat tccattgtat 256260 gagatgaaat gcagcactgc cttggggggt gctcttttca ttaggcccat gctattctgt 256320 cttagttgaa cacaatctat aggtatctct taattagaac cccaaaagca ctgacagtga 256380 cgtcctttgg ataggcctgt agtaagtgaa ctaagcggtg tccacctgag gccaaacata 256440 atctcccctc tccttcaagg taaacttcta taaaatagaa aacaaagaaa ctggattttg 256500 atgaatctga aatgaatccc tcttcatata tttattactc gtatatagga ggttttcttt 256560 tatacttttt gaggattccc caaaacaaaa ctgcacttgt atagctagga ggactaggga 256620 acaatgcaga cgtgggagaa agggtgagtt cttgtgaccc agaactgggt ttgaagcagc 256680 aacttccgtt caatcaagca tgcctctcag cattgcaggt gccaagttgc cattctctct 256740 ctttccttcc atgcgctcag gtttcccagc tctcgactgc tttttttctg acaccttttt 256800 ttatttcttc ctctccacag gtctctcagt tttgctgata aagatatttc actctacccc 256860 agtttcttta ttttgcattc cgcatctatt ccttaaaact gttttctgaa gtggcaaata 256920 cttttgtttt tgaggatgaa gattttggtt tttttcatgc tcactaaagt aaagcagatc 256980 ttgttgccag gattctccct cctctgaaga cagtgggtta taacaagtga caaatatttt 257040 cttcctgtct catagtaata ttcaaaataa gagatttatt gtgtctactc agtgtgaggc 257100 aagacagttt ataatttacc atttatttga gttgtgtgca gaaacctacg ttaactcaca 257160 ccatatttct tatttatttg attgatattt cagcacccct tgtagattga tgcctccagc 257220 agatactcag aagttcagct cattactatg tgtctgggcc actctgaccc tgagctctac 257280 ttagcctact catctctacg catagtgctc agagcaaata aaaatggatt tgaccattac 257340 agaagtctca gatcaatgca aagacacagt ttttactctg agcttggctc tcttctactt 257400 ttacttggtt tttagccttg atttcatttg tggttggtcc tgaggttgct cctcagattt 257460 catgaaacag tttaacttcc tagtttggac cccaagatcc ccttaagaca ctctctatag 257520 taaagtccat gggggcagaa atcatagatt ggaatcatag gtcagccact tgctagcttt 257580 gcgatcttgg gagattcacc tggcatctca gagtcaggct tctcatcagt aaaattgggg 257640 caatttagag acatttgtta caaggattaa attagagaag cagttaaatt gctttagcac 257700 aatatgagta acatggcaat gtttaataca tattatttgc aattataatt tcatcagttt 257760 attagtaaaa ttatatctca ttattgccat ttctagcaat cacccagtct ttctcatcac 257820 tgggctctca cccaggcatt tgcagtcctg gaatccatgg aaaagctcac cctcatccct 257880 ggtgacaggc atgttggaca gctactttcc agcatattat cacttgagaa ctatcacttg 257940 agagtcccct gctcagaaag atctcttcag atgccatttt gcattaactg tcagaggctt 258000 tataatcctt aaaacagtct tgctacatgc tatgagatat attttagaca tattttctca 258060 tttgatacat acaaactgtg taagattttg ttttcatact ataaagaaac caaacttcaa 258120 taggattaaa taacatatct atgggttatg gaactagtat taaaatctgt tcgtgataac 258180 tccctagaca tggtgctacc attatagcat gagctatagt gagtgaagat ttaggctgga 258240 gagtggtggg gcagaggctg caatatgctt cacttaaggg tcctcggaac gagtcaggac 258300 caagtaaaca gcttggctga agctcaggct ttcttgtaga tggagaattt ttttaaggag 258360 aagtgcattt catgaatttt caagcagaag caatatatgt aggcagtacg aagcatttct 258420 taaggaccca aagcaagtgg atgagaattg gagattgatc catcatacac tagctggttt 258480 ggtcttagga cattgcttag actctcaaaa actcagtatc ataaataaaa ttaggaaaat 258540 agtagtactt atcccataag aatattttga gaattaaatg agttaacaaa tataaatcat 258600 ttagtacatt atctggtgca tagtaagcac cgaagctatt gtcatttagc tctcattaat 258660 tcaagacaca aatataaagc ttaagcatat aataatgtct tgagagatac gacatttgac 258720 tataactatc attttgaagt tgtcatacca aggataaata cagcagaccc tggaacaaca 258780 tagatttggg ctgtgcaggt ccatttacac aaagattttc ttccacgtct gccaccttga 258840 gacagcagtg ccaacccctc ctctttctcc ttcccctcac cctactcaat gtgaagagga 258900 tgacgacctt tatgatggta cacttccact taataaataa taaatatatt ttctcttcct 258960 tatgattttc ttaataacat tttcttttct ctatattatt ataagaaaac agtgtgtaat 259020 acacataaca taaaacttat gttttaattt actgttgaaa ttattggtag ttaatggtgg 259080 ggcaagttag tgtccaaccc caatgttgtt ccagggacaa ctgtgtttga tgtaatataa 259140 tgtttttgtc ttaagagctc attagaaatt atcttttttc actttccaat tggaaagtat 259200 ttttttaaat ctcatgacaa tatatgaatt tgtcagtttg agctctgttt ccagaaaatg 259260 agcatctttg attttatgat atttgaaatt attgctctgt gtgtgcacat atatacatgt 259320 aatttataac taaatgacct tcttttgttt tcatttgtgt gtatcccttt gctagggctg 259380 ctgtaacaaa gtaccacaca ctgggtggat taagcaagag caacatagtg tttcacagtt 259440 ctgggggctg ggagtctgag atcaagaagt tggcagggcc atgcttcctg tgaaggacct 259500 agggcaggaa ctgttccagg cctctctcct agcttcttct ggtggtttcc tggcaatctt 259560 taatattccc tggcttgtag atgcatcacc ccaatctctg ctttcatgtt tttgaggtat 259620 tcttcctttg tgcatgcttg tttccaaatt tcctcttctt ctcagggcac cagtcatatt 259680 agggtagggg ccaccacact ccaggatgac ctcattttaa ctaattccat tccaacaacc 259740 ctattgtcaa ataaagtcac tttctgtggc acttgggatt agaacttcaa tatatgaatt 259800 ttcagggtgt ggggacacca ttcgactcat gcacatgatc ttcatttatt tcacatctat 259860 acattatata taattattta ttttatgtat gttatatatc atatgtatat atcacatgca 259920 tacatgcatt tccttaccat cacattacag tctactagat tatgtcctta agtgtcatgc 259980 ttttgccttt attcattaat aattatatcc ccagtttgtc agtactcagt gctgtatctg 260040 tcacactgta ccaatgcagc aaatgttgtt gtgaatacac aaaattctag agaaaataga 260100 aagggtgaca aatagttatg aataggtatg ggaacgaatg ggtataagga ttgtgtagaa 260160 agatgtgggg aataaatact cacacctgcc tagtttgggc aattgtacct aaagacaaca 260220 attctgctgg cttctctgtg actggtaggg taagccctaa gcacatgttc ctgcagtgta 260280 agggggatat tggggaaggc ctccggtttc aaattccctt tgctttatgc tctgcaagtt 260340 agcgcacatc agttcactag tttgaatgag attccaagca gccttctgac agcttcccag 260400 ttagggtcag tcccttttgg atcctatcaa tgatggctac tccatggtac ctggagaggg 260460 cttgctctga accactcaat caaccaccat gtgtcacact accctcattg acaaatccac 260520 tctcattcca tatttgggat tatacaattt taggaattct tattcctctc tttgtaaagt 260580 caaagattta tttataaatt atctgcaaag cattcctcag caagcatgtc ctttttgcaa 260640 tgctgtagca taacctactc ggtcaagttc aatttaacat tttgtgccat cattttctta 260700 gcttgaaaat gtcagccatt ttctacacaa acttggcatt cttctggttc aacacttctg 260760 tgagcttaag gcaattactg cagctgtgtt actttattca aatgtagcat acaactcaag 260820 ccaaagatgt tcctggtgga caaggtctcc tatgacactt tacctataaa ttatcatatt 260880 cttcacttac aaaccttaca cttatattac tattttaaag tactaaatat tttcaaatcc 260940 tattttttaa ataaacccaa agacaggact ataaaatgct atggaaaggg agaaaagaac 261000 acttaataac aagcagatgt cctcactgta tcctattctc ttggtatttc cttttacata 261060 tgtcatctta tttattcatt aaaacaacca tgcaggctgg gtgcagtggc tcacgcctgt 261120 aatcccagca ctttgggagg ctgaggtggg tggatcacaa tgtcagtagt tcgagaccag 261180 cctggccaac atggtgaaac cccatctctt ctaaaaatac aaaaattacc cggacccggt 261240 ggcatatgcc tgtaatccca gctacttgga aggctgaggc aggagaatct cttaaaccca 261300 ggaggtggag gttgtggtga gccgagattg tgccattgca cttcaccctg ggtgacagag 261360 tgtgactctg tcaaaaaaaa aaaaaaaagc aaattaagtg ttacagagca agaaattgag 261420 tatcagatag gacaaaatta atgtcccttg gattcacaac tacagggcag agatgggatt 261480 aaaatccaca agcaaaagcc atctaagctt cgttgcatta taccacagtt aggagtattt 261540 cattctgagt ttgaatggaa tatggtaaat attgttaaac acaggtaata catgaacgat 261600 ctgcaatttt agaggacgtt ttaataaact acctaaggac ctacagccct acagccaggc 261660 cgtggtagac tcaaggccaa tatttgccta ccaattaaaa taaaatcaat tcaatgtgta 261720 ttgttaatag ctcaaaattt ccatttaaca cagcttttac tattcatata taaaggtgaa 261780 attgtgtttg ataaaattgt ctttatatct cttaatagaa agatgatttg tttttcctat 261840 tatagctagt gctgaaatca ggcctattaa caaaaatgag ctgcagtcac agttttagta 261900 aataatacac tctcttgaat gtactttgag aggaaatata tttggaaaac agccctttat 261960 catttctgac atgatgtaaa catgtcacca ctctcaactt gtgcacttgg ctccaatttc 262020 tgagagcatt tcattctttt tttaaaaatt ggttacataa aagtaaagta ccttgattta 262080 tgcttggttt aattagagag aaaatgaaag aggcagattg acaaggaaag aaagttattg 262140 gagtagctgg accaggaggg gcagatgcca catttgcttg aggccactgg ggagaatgaa 262200 cccccaactc aggtctaagc agtacttttt ccatttgtag gaaaaaaaaa acaaaggagc 262260 aaaccaaaag ttagcaagtt gtgagggact ctctgggctc tgagattgga agtaggttgc 262320 agcaggaagg aactcgctaa gcgccctagt ctctgcatgt atttgggaca cacatctccc 262380 ttcttggtta gaacattgct atctcagctg actcttctat ctgcttttcc cttgaattct 262440 aaactttgtg tttctggcgt ttatatgtag tagttaaaat aatgaggtcg aagccagtgt 262500 tctgctgcaa atcttgacta tcctacttcc aagctttatg agctttggta agtcacttcg 262560 cacctctaag cactagtttc ttcatcagta aaatgggcgt aataatggct acctactcat 262620 gacttagtac attaagatac tgacaaactt catttgtagc aattgttaaa gatatttcta 262680 atgacaacat aatgcctgct gcagtgaaaa ttcaagatga atccctcagc tgagtgctgt 262740 gctgctgagg aagatcacac agccatccta agtagcttcc tagaaaagtg taatataagc 262800 caaaactggc actcagtatc atcaggatat cttctgtgtt tttctagaaa aatcagttta 262860 tattctcaaa ataaatactg tattatgact gtcttcacaa aactgctgta ctactcctcc 262920 tggctctact ctcaagtatg acattgttca aatgatattg agagaataga aatccataca 262980 cactatcttt ctcattttcc tgttaccaac tggtaagtct ccctgctcct cagcctttct 263040 ttcttaatcc ctactacaaa ataggaattg ttcattcccc tatcaaaggt cagtttttcc 263100 atcaagggcc tgtgtctcac accttcctgc tctgttgggt tatcctcttt ctcctgaaac 263160 atatgcatgc atatttctgt tggataattt tcaataggac aaagacatgc tctggtacca 263220 ttaatattta aaatgaaaaa ctccagtgtg gtatccagga gaaaagtaaa taaataataa 263280 ataaaatttt aaaaaacaca aaacaaccca ttctcttttt ccttcattcc catttgatta 263340 ctgttttatg tttttgcttt aaattcagag aaattttttc caaagaggtt taatcttcct 263400 gctatccatt ccctactaaa ccaattccaa cagtcttctt cttgcctcac tccatttgtt 263460 cgtttatgta gcgaatgaac aggctaaatc tatgctaggc tttagagctg caatagtaag 263520 cgagacaccg attcttcatg gcaattatat agtctagaat taaaaaggat tttaaaaagt 263580 gatcacatat aatcttttat tatagaagat atttacagga cagaaaccat taataaatat 263640 agatagtgac cgaggttcac ctggagaaga ctgtagggcc tgtgggaaaa gctcactgga 263700 atccttctgg cacagggaag tgaagttctg ggtttggttc caggtctctg tggaacgtag 263760 ggacagacac tttaggtaat gtggatcttt tcaaaaacag aaaatattaa cagtttaata 263820 aaaaagagga cctagtcaag agcagaagaa acagtattca aggaagggca aatgagcata 263880 tgccaagacc tgatggagga aagtttgaac gatcaggaat tatgaccaag acacttaata 263940 ataatttgga atggaagagt gaagacaaaa aattagttga gaatatttaa tgctttcttt 264000 ttttaagaaa tagtcctact tattaggctt tctgctgtgg tggtgaaagc agagatggag 264060 gtgtatacct ggaagagatt tcatttttct agataattat agaagctaaa tcatgagctc 264120 atcactctag ttttttgtat gtttgaaaat tttcataatt cttaaaaatt attttgtaca 264180 aaatcatcat gtaaattttg aaatacctct gagatatcca agaggaaaca tctcatagaa 264240 gcactatgta tattcactaa tgtttcacgg tgatacaatg atgagagact tacatttgta 264300 aattatattt actggaatgt tttcgatcac ctcgggaggt tgtgttggga gaagagagac 264360 aagtaaagca agactgaatt ctgaggaata ctgtacagac attctgcaaa gaagactctg 264420 ggttaaaaca gctggtgagg tcagaggaaa cagatatacg tgtgtttatg aataaagaca 264480 ggagaagaag gtgctttaaa aagaaagcac atttcagcag tgttgacttt tgcaatgagg 264540 ttatgatgaa gctgaaaaat acgcactgag tcagtcacca tcgttgtctt ggggactcca 264600 tgttaaaaaa attcttttgg tcagggtagt aacactccct ttgcctggct tagaatttag 264660 ttcatcgctt ctttactgtt ccaaatgtcc acatttgcag atgaatatga ggttatagca 264720 attcttccat agtaagataa gaccaatatc attgctctct tctatagcta cataaagtgt 264780 aggtaccagg gccctaactt gagtataagt tgtgaagaat atgaaaactg aggtccacat 264840 agataaaccc gaatggccta tgggaaaagc ccatgaaacc tcctggcaca gaaaagtgag 264900 gtttccaggt taagttccag atttttgttg aaaataatga caatttttat tgtctttgtt 264960 gaagataagt ccagtagagg aaattctact caggctgtct catagtaagt gattctagca 265020 cagaaaatag cacagtgcct agctcacaga atatgatcaa taaaaaatat gtagtgactg 265080 atgcttgctg gtaattaatc ctcagttgca attaaaacac acaacaactt catcaagtat 265140 ttacccatcg taattttttg ggcctggaaa tggagacttt tgagaggcta atgacacatc 265200 caacatctca tagttactag cagatttcat gttctaaaca aattgttctg acctgtcagg 265260 caacaaggag gtagtaaatt agccttaaga tcattatgtt acttgagtgt catacatgta 265320 ctggtatatt tctcattgta ttgaagtttg tttctttttt ttcttcatct ccaaatgtcc 265380 tctgattgct attgtttccg tagctgagtc acgcctgaga catctcactg actttctttc 265440 ctaactactt gatagtctaa tgaaaggaaa gagagggagg tgaagaaata gaataagata 265500 aattagtaac ttctggacaa ttctggaaaa ctgaaactat aggattaatg ttcagagcga 265560 agtacaataa atggaccata agtcaaatat ttcataataa ttctgtagaa agtgacattt 265620 gaaaactcaa attgtacaaa accaaatctt tccttcatga tggcaaaggg atgggtcaca 265680 ccttaaattt cttcccagtc tccatgctat agccacactc tatggggaaa aatagccggg 265740 gggggcgggg gtcattccat tacttgaaat gaaagacacc attctaaaga aatttcaaat 265800 ttctttacat tattaataca ttattaaccc tatacatgtt tagcaatatc tttctcaaag 265860 ttagtaaaag gaatgcacca ttattttgtg agaggggctg tggaaaacag ttcttgctta 265920 ttggacatat ctgatgggga gaggtcagag gtgttaatgt aaccagagca tgtgcttctc 265980 ttatacagtg ggatccacga gggggataga tgactggttg tctggtgaat gcagtgttac 266040 ttttattagg ccataaaaag gaaagtttca aggccaacta attgtattgt ttgtcatagc 266100 agtgtccctg taaaaggagc atattttcca acctcggcct gggaagatgc aacatgaact 266160 gtcactaaaa ttaaggaaac atctctaaat caaactaatt tagactaaat ttagactaca 266220 tttagtcatc aggtagttta tggtgacccc attctctgca tgtgctgaaa aactatggct 266280 gtccatctct catagcctgg gcaggtttgc acaaaatgta tttgtgctag aaatccagaa 266340 aaacaaacta ccacacacca gcataaaaat tgaagctcag aaaagtgaat tgaagtcctc 266400 agagcatcag ttttcttact ggttgtatcc attttctgga cttgccataa aagttgccac 266460 aaacttggtg gcttaaaatc agaggaatgt gtcgtcttaa tggtttttga ggccagaagt 266520 ccaaaatcaa agtgtcatca gagtcacact ctctccgaag gctctagggg agaatccttc 266580 cttgctcctc ttggctttgg gtggctcctg agagtcctca gctgtgacag cctcactcca 266640 gtctatgcct ccattttcac gtgtccctct ttcctgtgtc tgtgtgtcca ctcctattct 266700 tataaggact ccatttatta aatttagggg ccaccctaaa tctagagtga tttcatttca 266760 agatatttaa ctaattaaat ttgcaaagac cctatttcca aataaggtca ggttctcagg 266820 ttctgagtga acatgtattt tgggactatt caatccacta cacccgtaga ttgagctggc 266880 agttcttaac ttataagact tattgtgact gaataacttt tctgtaaagt atttggtagc 266940 taataggtga tcaacaaatt ctttgttttt aagaatacca ctatagttat ctttaatcct 267000 gaccatgact gtctgaatat tctcattttc ttaaatatat tagtatgttc aattcttaca 267060 ctggtctagg cattcattat ggaagcaacc tgctatatgt aaataagcat gattttaatc 267120 ctatctagta ggctgtgtgt tataaatgat ccctagaaac atagacattc cgttgtggga 267180 gcacggaaaa gggagtgatg atttctgaga agatatgact tgtaactttc caataacact 267240 tttctagaag ggtctcatgt taaaataaat aaatgtcaaa ctaaactaag agacagcact 267300 ataatgtact aattggctcc cagattaggg ctcttaacca tcaggctatt ctgcctccca 267360 aattaaaatt ggtagcggga catgaattta ttgtttgaaa tgagcacagg ttaagtaaaa 267420 tgagaactat ggaaaaacaa tgacaggaag aacgggagaa ttatactttg ctaacagtaa 267480 tagtaaatag tgaacattta ttgtaaataa gtttaacaat acgcatttaa gacaaattta 267540 agagcttata ttttttgacc agtaattcct tatttaagaa tctaactttg gaaatcatac 267600 aggatttgta gaaccttttt acagaaagat actcattctg gaaatatttt taacactgag 267660 atttggaaac aatataatgc ccaacctcaa aggattaata aattaaattg tgatattatc 267720 ctcaattgaa tactatgtgg tcattataat tcatgtttca aaagagtata ataaaatagg 267780 agagtcctgg gcttttactc tgagtgatgt tggaagccat tgaaggtgga ggagaaagaa 267840 atgagaagaa cgtttccaaa caatgaagat gtccagccag tcattgacaa aaatgttctg 267900 ttaatcatgg tggatgggaa gtaggactag attgcagctc tgtatagatc agtgtgcaga 267960 ggctcgcatt gtgaatttta gctccaggtt gactgcaaga acaagccagc aatcccgaga 268020 gtacccacag actctctgaa ggaagcgaac tgtttctgca gtacccaaga gacaccacaa 268080 atactgtcag tgccccgacg ctggaagtgg taaagggaga cccccctctc tggaacacac 268140 agccccactg gagaaactga aggtctcttt gtgggagaag tttcctacct tctctggagt 268200 tgaatccatt tagagagctg agcaaaatac agggtttgag gaagcagtag aaaggccctg 268260 ggagctcact gggtgcccaa acaggccatt cctgcttggc accacaggga tccattgtga 268320 gggtggccag aggagcaggt gttgaaactc cacaggaaga aagaaatcta tagttgaact 268380 ttgtaacaat ttgaacaggg cgagaagcct cctggccaga actcatggga gggcacaaat 268440 ctgttgtgca gactccacag gcaggggaag aaccaagccc tttttttcca tagttgagag 268500 gcaggtagcc tgaggcaagt tttcaagccc atcttgccca ccacctggaa acaggctcca 268560 tgagaactgc tctttggttt gcatgggagc tgggtgaggc ctatgactgc cggctttccc 268620 ccacttccct gacaacctgc atgactcagc agaggcagca taatcctcct atgtacacaa 268680 ctccattaac ctgggcatct cacccctatc ccccacaaca gccacagaaa gacccacaca 268740 aggagagtca gagctcagac acacctagcc ccacccccaa ctaatggccc ctccctatcc 268800 accgtggtaa ccgaagacaa agggcatata accttgggag ttctaggacc cccaaccccc 268860 accactggtc cctatacata ctactacagc tgatactccc tggagctgat tcctcctggc 268920 aggaggccaa ccatcacaaa actagagcat taaagctaag aaccctcacg gagtccattg 268980 cactccccac cacctccact ggaacaggaa ctggtatcca tggctgagag accaatagac 269040 ggttcacatc acagtactcc gtgcagacaa cccccagtgc cagcccggag ctgagtagag 269100 tcactaggtg gctagaccca gaaaagagac aacaaacact gcaatttagc tcacaggaag 269160 ccacatctat aggaaaaagg ggagagtact acaacaagta aacacaccca tgggacaaaa 269220 gaatctgaac aacagccttc agccctagaa cttccctctg atagagccta cccaagtgag 269280 aaggaaccag aaaaccaacc ctggtaatat gagaaaacat acctctttaa cagcccccaa 269340 aatcacccta attcaccagc aatggagaca aaccaagaag aaatccctga ttaacctgaa 269400 aaagaattta ggaggttagt tattaagcta atcagggagg caccagagaa gcgcaaagct 269460 caatgcaaga gaatccaaaa aatgatataa aagtgaaggg aaaaatattc aaggaaatag 269520 atagcttaaa gcaaaaacaa taaaaaattc aggacactct gaacacactt tcagaaatgc 269580 aaaatgctct ggaaaatctc agcaatataa ttgaacaagt agaagaaaga aattcatagc 269640 tcaaaaagaa ggtcttcaaa ttaacccaat ccaagaaaga caaagaaaaa ataataagaa 269700 aatatgaaaa aagcctccaa gaagtctggg attatgttaa atgaccaaaa ctaagaataa 269760 ttggtgttcc tgaggaagaa ggtaagacta aggaaagaat cttaagagct gtgaggcagg 269820 agcaccaggt aacctataaa ggaaaaccta tcagattagc agcagatttt tcaacagaaa 269880 ccctgcaagc tagaagggat tggggcccta tcttcagcct cctcaaacaa aacactattc 269940 agccaagaat tttgtatcca atgaaactat acatcacata tgaaggaaag atacagtctt 270000 tttcagacta acaaatgctg agagaattca ccattaccaa gccaccacta caataactgc 270060 taaaaggaac cctaaatctt gaaacaaatc ctggaaacac tcaaaacaga atatttttaa 270120 ggaataaatc acacaggatc tattacaaaa atactagcta aaaagcaaaa aaaaaaaaac 270180 caaaatacac aggaaacaaa gagtatgatg aatgcaatag tacctcgcat ttcaatacta 270240 acattgaatg tatatggcat aaatgctcca cttagatata taaccgcaga atggaaaaga 270300 acttaccaac caatcatctg ctgccctcag gagactcacc taacacgtaa ggattcacat 270360 aaacctaagt acaggggtgg aaagaggcat ttcatgcaaa tggacaccaa aagctagcag 270420 gggtagctat tcttatatca gacaaatcaa actttaaagc aacagcagtt aaaagagaca 270480 aagaaggaca ttaaaggcct tgtccaaaag gaaaatatca caatcctaaa catatatgca 270540 cctaacactg gagctttcaa atttataaaa caattactaa tagacctaag aaatgagata 270600 gacagcaaca tagacaccaa tagtggagga tttcaatact ccactgacaa cactagacaa 270660 ttcatcaaga cagaaggcca aaaaagaaac aatggattta cactatgcca tggaacaaat 270720 ggacttaaca gatatgtaca gaacatttca tccaacaact gcagaataca cattctattc 270780 aatagcacat ggaactttct ccaagattca ccatatgata ggccataaaa caagcctcaa 270840 taaatgtaag aaaattgaaa ttatatcaag caccctttca gactacagtg gaataaaacc 270900 gggaatcaac tctaaaagga atcttcaaaa ccatacaaat acatggaaat taaataacct 270960 gctcctgaat gagcactgag tcaaaaacaa aatcaagatg gaaatttaaa aattcttcaa 271020 cgtgaatggc aataatgaca caacctatca aaacctctgg gatacagaaa aggcagtgct 271080 aagaggaaag tttataaccg taaatgccta catcaaaagg tctataagag ggccaggttc 271140 ggtggctcat gcctgtgatt gcagcacttt gggaggccga ggtgggtgga tcacctgagg 271200 tcaggagttc aagacgagcc tgaccaatat tgagaaactc cgtctctact aaatatacaa 271260 aaaattagcc aggcctggtg gcacatgcct gtaatcccag ctactcggga ggctgaagca 271320 ggagaatctc ttgaacccag gaggcggaag ttgaggtgag ctgagattgc gccattgtac 271380 tccagcctgg gcaacaagat taaaaaaaaa aaaaaaagtc tgaaagagaa caaacacaca 271440 atctaaggtc acaccacaag gaattagaga aataataaca aatcaaaccc aaacccagca 271500 gaagaaagga aataaccagg atcagagcag aactaaatga aatggacaca cacacacaaa 271560 tatagaaggt aaatgaaaca aaatgctggt tctttgaaaa gataaataaa actgatagac 271620 cattagcaag attaaccaat aaacgaaggc agaaagtcca aataacctca ataagaaacc 271680 aaacaggaga cattacaact gacgtcactg aaatacagga tatcattcaa ggctactatg 271740 aacaccttta tgcatataaa ctagaaaacc tagaagagat ggataaattt ctggaaaaat 271800 acaaccttcc tagcttaaat cgggaagaat tagataccct taacagacca ataacaagca 271860 gcgagattga aatagtaatt taaaaaatac aaacaacaac aacaaaaaaa gtccaggacc 271920 agacggattc ccagcagaat tctaccagat attcaaagaa gaattggtac caatcctttg 271980 acactacttt acaaaataca aaaagaagga accctcccta attctttcta tgaagctagc 272040 atcaccctaa taccaaaacc aggaaaggac gtaatcaaaa aagaaaacta cagaccaata 272100 ttcttgatga acctacatgc taaaatcctt aacattatgc tagctaactg aatccaacaa 272160 catatcaaaa agataattca ccatgatcaa gtgggtttta taccagggat gcagggatgg 272220 tttaacatat gcaagtcaat aaatgtgatg caccacacaa acagaattaa atacaaaaat 272280 cacgtgacca tctcaatagc tgtagaaaaa acattcaaca aaatccagca tccctttaat 272340 attaaaactc tctcccagct actcgggagg ctgagacagg agaatctctt gaacccggga 272400 ggcggaggtt gcagtgagct gagattgcac cattgcattc cagcctgggt gacaaaagct 272460 agactttatc taaaaaaaaa aaaaaaaaaa aaaaaaaacc agctctcagc aaaatcggca 272520 taccagggac atatcttaat gtaataaaag ccatctatga taaacccaca gccaacataa 272580 tgctgaatgt ggaaaagttg aaagcattcc ctctgagaag cagagcaaga aaaggatgcc 272640 tactgtcacc actcctcttc aacatagtgc tggaattgct agccagttca atcagacaag 272700 agaaagaaat aaagggcatc aaaattggta aagaagaagt caaactgtca ctattttctg 272760 atgatatgat tgtttacctt gaaaacccta aagactcctc cagaacactc ctagaactga 272820 taaaggaatt cagcaaagtt tctggataca agattaatgt acataaatca gtagctcttc 272880 tatacaccaa gagcaaccaa gcagagaatc aaatcaataa ctcaacgctg tttataatac 272940 ctgcgaaaac aaaaataaaa tacttaaaag tatacctaac cgaggagcct aaagacctct 273000 acatggaaaa ctgcaaaaca ctgctgaaag aaatcataga cgacataaac aaatagaaac 273060 acatcccgtg ctcatagatt tgtagaagca gtattttgaa aatgaccata ctgccaaaag 273120 caatctacaa attaaatgga atgcccatca aaataccacc atcattcttc acagaattag 273180 aataaacaat tctaaaattc atatgaaacc aaaaaagagc ccaaatagcc aaagcaagac 273240 taagcaaaaa gcacaaatct ggaggcatca cactacctga tttcaaattc tactataagg 273300 ccgtagtcac caaaacagca tggtactggt ataaaaatag gcacatagac caatggaaca 273360 gaatagagaa cccagaaata aatccaaata cttactgcca actgaatttt gacaaagcaa 273420 acaaaaatat aaagtaggga aaggacaccc ttttcaacaa atgatgctgg gataattggc 273480 aagccacagg taggagaatg aatctggatt ctcatctctc accttataca aaaagcaact 273540 caagatggat taaggactta aatctaagac atgaaactat aaaaattaga aaccaaaccc 273600 tttagacatt ggcttaggca aggatttcat gaccaagaac ccaaaagcaa atgcaataaa 273660 aacaaagata aatagctggg acctaattac actaaagagt ttttcatggc aaaaggaaca 273720 gtcagcagag taaacacaca acccacagag tgggagaaaa tcttcacagt ctatacacct 273780 gacaaaggac taatatccag aatctacaac aaactcaaat cagtaagaaa aaaacaatcc 273840 catcaaaaag tgggctaagg acacgaatag acaattccca aaagaagata tacaaatggc 273900 caacaaacat atgaaaaaat gttcaatgtc accaatgatc agggaaacaa aaatgaaaac 273960 cacaatgcga taccacctta ctcctgcaag aatggccata ataaaaaaaa taaaaaaaca 274020 ggagatgttg gcatagatgc agtgatcagg gaatgcttct atactgctgg tgggaatata 274080 aactagtaca gacactatgg aaaacactgt ggagatttct taaagaatta aaagtagaac 274140 taccatttga tccagcaatc ccactactgg gtatctaccc agaggaaaag aagtcattat 274200 gcgaaaaaga tgcttgcaca agcatgcaca attcacagtt gcaaaattgt gaaaccaacc 274260 caaatgccca ccaatcaacg agtgggtaaa gaaactgtga tgtatatata tatataaaat 274320 atatatgtat aaactgtgat atatatataa agaaatatat atgatggaat atatatatac 274380 atatatatat atatgatgga atatggtgaa tatgatggaa tactactcac ccataaaaag 274440 gaatgaatta acagcatttg cagtgacctg gatgagattg gagactatga ttctaagtga 274500 agtaactcag gaatggaaaa gcagacactg tatattctca ctgatatata ggagctatgc 274560 tatgaggatg caaaggcata agaataatac aatggacttt gcggatttga ggggaagaat 274620 tggggggagg tgagggataa aagactagaa atatggtgca gtgtgtatgg cttgggtgat 274680 gggtgcacca aaatctcaca aattaccact aaagaactta ctcatgtaac gaaataccac 274740 ctgtacccca ataatttatg gaaaaataaa taaataaaat aggaaaaatt actttcactc 274800 tcaactatgt gtagcttaga ttgagtgtcc ctagaagacc ctgagacaag aatttgtgca 274860 agttgtttat ttgagaaatg atagtaacaa gcacagtaag agaggcaaag aagtgagaca 274920 gacaagggaa agatgccact aaaaaatggt ttaaaaaaac cccataaaac aaaacaaccc 274980 ccccaaaaaa ggctatgttt tttcccaaaa atatatcatg tttattgagg tataacatac 275040 agggttaaat aaagggtttt agtcccatat acacagtcac ataaccacaa tcaagatgta 275100 gtataatttc ttcacttatc aaaatgtccc acattcttgc tcctgatagt caatccccca 275160 ctccctggag aacactgatc tgttctttgt ccctctattc ttgccttttc cagaaagaca 275220 tatatatgga attatacagt agccttttga gtctggcttc ttcacttaat aaaatgcatt 275280 taatattgaa caatgttgtc gcatgaatca tgttttcttt tttaattttt aaattgttga 275340 gcaatattcc cttgcatgaa tgcactacca cagcagttgc cattcatcag ctgaaggaca 275400 gttaggttgt ttccagttct tggtgattat gaacacagct gctataaaca ttcatatgga 275460 cataagtttt cttttctctt gagtaactaa ctaggaatag tattgccagg acatatggtg 275520 ggcatatgcc taaacttatc agaaactgct cagtgggcaa ctgggactca ctcctcctgg 275580 agacttcttg tagactgcac aaaactatgc ttcacagttt ttccattcaa gggaccagga 275640 agctggggga ttcatttgtc ctccaactct gccattagtt gaaggttgct ctcaagagta 275700 ttaaccctag agcatctatg gcccatctgg tacagaatat gcatgttcta aaggacatag 275760 taaaacctag gttagaagtt gaagctgttt tcagtaggaa gccttggggt tgatatgcac 275820 agaatgttga ggcctgccag caccttctac atcatgtggg gaaacatgtt gccattcaaa 275880 ttctagtaat aattattttt gtgggggtgt aaggctttaa caggaacatg actttccctt 275940 gtctcagaat cctcaaatat aagaaatctt atgttagtat attttgtaaa taatcacaat 276000 aatactgatt attaccgtga gagagtttat gaagcactta ctatcaggga actatcatta 276060 tctctgtttg cccagggtga tattgctagg agatagtgaa gccactattc agttaagcag 276120 cctggtttca gaaaaggtac ttctaaccac tatgttatac tatataatcc tgttataact 276180 taggttatga gaatttctac aaataaaaaa aagagaataa acaagagttt gtatataggt 276240 cactgaactg ttcatatata ataaaatagt aaacaaaatg taatgttcta caaaatactg 276300 tgcttgtgtg gtgggttgta gggattttgc ttctgtttcc ttgttttgga taaatttaat 276360 ttaaagatca tgtgtttgtc tatggaaaaa tattgaaatt ttactttttt aatgtaaaga 276420 atgtgtgttt tttaattaaa aaatttaaat ggactattaa taaattataa ttatatatat 276480 ttatgaggta cacatatgta caattataat ttattgtata tatcatgttc acttatacat 276540 atgaggctaa gacatatgta tacaaagtgg aatgatcgac tcaagctggt taacatatcc 276600 atcacttcag atactattaa atgatggtgg gaagaggtca aaataacatg gggaaaactg 276660 aaaactgaat cctgattctg cagttaagaa gcagttgtaa tggtgagatg tcaactgcca 276720 agagacaaag gcagagaagt attaaactct ctgggtgctg tgttctttaa gagcatctgt 276780 ctttgctgga aagattgatt ctggcttgca ggcagtcatt accacagtgt ccaacatcaa 276840 aaagcctcct tgctctaccc ccagcagttc atcgattctg gacaaccctg ggtggtcttg 276900 gactcttacc agcatctgct tagcctcgaa gcccctccaa atctcacttt gcctccacag 276960 gccacattaa gttcaaatta acgaattcct ctaggcagaa ctttttcaaa gagttgaagc 277020 caaaataaaa gttaatgaat tccagcaaag gcaaaagacc tctggataga tgttttgccc 277080 tttttattca ttgaactcat gcagttttta ttttctcagt tttctctgtg taaaactctc 277140 tgttccacca atgtttccaa aattaatttt gaccttctgg caacatttta atttcacatg 277200 ccccagtaga ttctctttat tcaacaactt atttcatata ttcattattc cttttagaaa 277260 atagcagtat cgtgctcaac ataagtattc attatatgcc taattacact gagaactgtg 277320 cacagagaca agagcctggt gcagaggaag gagcacttgt ctgaggggag ccgacccagc 277380 ctcatgcagg gcggcgaggc tgaagtgtaa ccctgaggac agggggcgag gcaggagctg 277440 aggacagaga gctgacttgg gacgaggttg ctcaatgccc tgggtaacat gtgaaggagt 277500 ttagatttta ttcctgagcg tggaagaaaa ccatctcctc ctctaatttt aaaccttctt 277560 gagggcaggg catgtgtaat tctgaatatc tcttagtatc ttctagtaag tgttgaggac 277620 aagttatcat taatagcaac tacttatata ttgtggctca gcaccttcca aataccctaa 277680 caacaccatc cccaaatctt cacaaaacac taaaagttgc tatcatttaa ttgaatgtat 277740 ggatactcaa aaataagact cagagtagat gagttgcaac tgctttgttg agtatctaac 277800 gtgaaagatg tagagagaag caagaccatt ttatgaaatt gtcactgtcc cataatagat 277860 tagagtaggt tctaactcca gcttttccct tctccatgct tgtgactttt gacaaatcag 277920 ttttttacat atcaatgggc atttgttaaa aatctcctga gattgaggca tgatgcttgg 277980 ttctacgatg gagaggcaac aaaaacagtc tttactctca aggggctcat ggtcttgtag 278040 tagaattaaa atttacaagc aagtaatagt aaatcaatgt gaaaactaca ttaataaatg 278100 tatacaattt attaagggac aaattaactc tacagggttt tataataagc tgacatgaaa 278160 atgactaatg gtttgccagg cagaggagaa tgagacagac attccaaaaa agaaagaata 278220 tccacaaatc catggatgtc caagtgtgag aagactggtc cgcccagatc atgtgggcac 278280 ttatagcctt caatcactgt cttcacctcc agtctacaga tgtgtggctg ttaaaatggg 278340 ttcctgggaa ccccagacgt cctgccagtg ttgcaaacat aaccctgtga ggcccagcat 278400 ttgcaagacc agcaaagaga ggtgataagc agacaaaatc caggcctctc atcatattaa 278460 ctgtgtgaca ttgggtaagg gtccaaatct ctctgtgcct cagtttccac catatgtgcc 278520 attgggaaaa taagagtaac tatatcacta ggttgttgag gagataaatt atttgaatat 278580 atgtaatgtt tttggaacaa ggcctggtgt agagtaaatt tcatgtaagt gttagctaat 278640 tttatgatgc taatcacact ttaaacagaa ggaatcttct ttacctattt tataccttca 278700 gctttcatat aagatatatt ttgaaaaagt gtttgcacaa aatctttcta aaaaatttta 278760 atataacccc tataggtcca ttctttcaac aaatatgtaa tgagtatctt tttgttccag 278820 gcaatgtgct cgggataggg cagcaacaca tttaacaaat acttctgcca tcatgggctt 278880 tcttctgaat ggggtaaatt aaaaagttat atatatatat atgtgtgtgt gtgtgtgtgt 278940 gtgagagaga gagagagaca ttatattgtg ttaaaatatc tgagaaaaat aataaaaatg 279000 ttggagaaat aatgctgtga gtggggtgtt caacaccaag tagggctgat agagaaggcc 279060 ttggtagaag gtgatgtctg ggagaagtca cgaagcaggt gagggaagga gttagtagat 279120 tcctgggcat ggtgggagca ggccctgtgt gttgaggagc tgccagaagg ccaaggaaag 279180 caggaacgaa tgacatgaag aagcatcagg gagggaggga ccggtagcca aaggtgagag 279240 gctatacaga ttgaggtaac attggtaact tggaagactc agggttttat tccttgaaga 279300 tggggaagat gggaaattac aggagggttt ggagcagaag catgacatgg gtgattaagg 279360 ttttatgcaa atactaggct gtgagtggtt ggtgggagca taggggtatc ccaaaggcta 279420 ggaaataagt tactcagcaa ttcacagaag agaccatggt ggttttgatg agagtggtag 279480 caataggagt agtgagaagt ggtgaaattc ttggtaaaat ttccaaaggt tatataaggt 279540 tgtatatagt gagactgtgg cagagtgtat ccattaaaat cttttttgtt gttgttgttg 279600 agacagaatc tcgctctgtc acccagcctg gagtgcagtg ctgcaatccc ggctcactgc 279660 aacctctgcc tcgcgggttc aagcgattct cctgcctcag cctcctgagt agctgggatt 279720 acaggcgtgt gccaccacgc ccggctaatt tttgtatttt tagtagagat ggagtttcac 279780 catgttggcc aggttggtct cgaactcctg gcctcagggg agctgcccac ctctgcctcc 279840 caaagtgctg ggattacagg cgtaagccac caagcccagc ctaaaatcat ttttaactga 279900 tgcctttggc gcttccattt ctgggaaatt gttcagtagg ttcctgatta cctagtcaag 279960 aaagggttat gggagcagag cagggtctgg ctcttattcc aagcacaggt gcagcccaat 280020 ggttttcctg tctttagaca agaatgctta gtaattccct tgcttaaatt gttcctccat 280080 ctctgtcatt gaatagaatc tgaccctgag taatgtgact taatgagggc agtttgactg 280140 tgcattcaaa gaaccactaa atatatgttt actttatatt tagtctcagc cattatgcat 280200 aattatattt aaaagggcac tgaatagata agttacaagc cacaacaggt gtgactggag 280260 aaacacagag aacgcacata aaatctggga gagagagcag gttacataaa tttcccatca 280320 gggcagagaa atataaggta tatttgaact ttgaagccaa tcagtgtgca accaggtaat 280380 tacaggcagc ctacaccagg atgggagatg ctggagtgtg agcttgggaa tgcccccata 280440 actcattcat cttcaaagtg cccttggggg cccggcctca ccagccagga aatccaggat 280500 cgtcagttgg aattatatca acatctgaga ggccatggag ggaatgaacc tcatttacca 280560 tgattaaagc agatgaactg caggtttagc tcttctccat taaattcctg ttaaacttga 280620 gaacttccac aggcattatc ttattaatag gcaggacagt cattaacagg tgatgaaagg 280680 agggaagaaa tgactgtgaa atttctgaga atttaagaat gtctgcttca tgtacagtta 280740 agaaagaaac taacattcaa catttttatc aggaatttgc atgcattatt tcattcattt 280800 ctcatatcaa atctgttctt tattggcatc aatctaaata aggatactga cggaaaatta 280860 atataaaaat tattttaggc ccacgttgag gattgaagcc tgggaaatac ctggaaatgg 280920 cttcattcag ccttcgttac aagcaggttt ttagaagtga aagggaataa agaatgtgct 280980 gatacaaagt tttttgttag gaattttcaa tggtttacag aaataacatt gattagtgat 281040 tggctataca ttttagagct ctgggttatg agttatggtg tccagcgtat ggcattgtta 281100 ggttaattta tggctacttg tcatcaagta atccagagcc cacccagcaa gtggcttcaa 281160 aaggtgatta cttagctcaa ggttggggtg gtggggaatg agacctcact gctgtctcac 281220 cttaatggcc cttttcagat tgctcagata atagtttctt ctctttctca taaataaagg 281280 aagagagact gaaagaatct tagtaatttt ctagaggtgg tattttctag attcagaatg 281340 aactacacaa atattgagtc ccctgttatt tccacactat catttgtcct ccaaaaggtg 281400 aaatgcattg tctgacatca tattttagtg acagagcctg tccttgtacc aaggtctctt 281460 gtggttttct ctatagtctc atgccagctg cctagctatg ggcccacaga atcaaagcct 281520 ggagagttcc tatgaagacc tagataacca ggtttcaaca tagctctgtc tctggagtga 281580 gtggtgaagg aaggagggga gcagaccacg tagccgactt ctctatttgc attttttact 281640 tattgttttg tagtgcaagc atcaaacact ggaagcggct gagcattttt ctctaagtat 281700 ggcgaaagct tgcctttttt caggtcttct tcttctttct cattaaatca ctttggtctc 281760 acacaacaaa atagtcttca gggatggcct taggcaaagc tgtaaaatct atcctctgtt 281820 cccagaactt ctccttgttt gtcctctctc tcattctgtg aatctctcat cctcttctga 281880 tacttaggaa atttctctca tacaagctca aaaaaggatc cagatcattg tatgcatgaa 281940 aacaaggcct catttgcaat tcaaagggca ggccaactgt gattatgcct cttatgtgtt 282000 gtgaatccaa tgaagaattt taataaaagt tctaaattga ggcatagcca cattctaaaa 282060 gcaatggaga atgatttgtg ggacatgaaa acgtgtcacc ctttaccatt gctttcttta 282120 acgttattca gttaagtctt aattctcaag tttctatatt tgattttttt caaattatgc 282180 tccaacctat agactaaatg gactctctgt ggctgagatg ctcaaggtaa agcagaacca 282240 ggcagccaca gcaggatgag ggggtcatca tgcatactgt gcgctcggaa aatgttgcaa 282300 aaatgtcaca agacatccct tcctgcaatc aagccaaact gaaataggct acagctggaa 282360 attcccaaac agaccaacaa ttgtccacca agagtcagcc aacaaagaga gacctgtggt 282420 tttacactta caggtcatcc attcaaggct ctgttcctca ctcccccagg ccccttcctc 282480 ggcctttcgc tttttacctt tataatctct aactctccaa cccttcctgg gagtgcactt 282540 tcactttatc ccaaaggcta ctcgtctcca atctataggt cactgtcaga aaataaagcc 282600 cctttctgcc tctgtagatc tcatcttttg ttaatagctt taatattcta aaaagaagat 282660 tcacaaacac ctagacccgt ggctgaacta agtttaaaag acgattgatt gagtgttgtt 282720 ttctggatcc agttgaagtg tgttactcac ctactgagct agtaagaatt cccctaggaa 282780 gaacagtaaa aatgaagaaa acctgagctc cagagtcaac gtagctgtga taggctcaat 282840 aatagcccct ccacagttgt ccacgtttga atactaaaaa cctgtgagca tattacctga 282900 catggccaaa gaggctttgc agatttgatt aagttaaaga tcttgaagtg gggagaaaat 282960 cctagattat gtggatgagc ccagtgtaat tacaagagtc cttataagag gaaagcagaa 283020 gagtcagatc ctgagaaagg gagaggtgac gacagaggca aagatcaaag aatcagagag 283080 acagacgttt cagatgtcat gctgctggct ttgaaattgg aagaaaggtt tgcaagctaa 283140 tacgtgcagc ctctagaaaa gacaagggaa cacttttttc cctagagcct ccagaaagaa 283200 ggctactcca ctgataccct gattttagga cttctgacct ccagagctgt aaaagaataa 283260 atctacgttg ttttaagtga ctatatttgt gatcatttgc tacaggagca gtaagaaact 283320 aatacagtgg tcggtgaaga tgatcttccc tagtaatggt tagtatttga ggcaattaga 283380 ctttgtagag ttgcagctgt tgtaggggaa tattataaga tcgtgttaga aaatacttca 283440 ggagaataag gtgaaaatgc ccacggcgtg taccagcagg ctccaaagcc tttgaaaaca 283500 gaaatggtag cagtaaacaa acggcacttc ttggagtaaa tattagcgtt ctattaaggg 283560 ccttaagatt gtaaattgtc acattccacc aaaatgctct tttttctcct tctcttttta 283620 aaggtttgtc caatagaaca taaaactgtg acgcttgaag ataaacgtga ccttgaccag 283680 ccctgaggtg agcagtgatt tctttcaggt gtcaatcctc agcaaatgca agagaaatat 283740 taacctgtgg caaaatgtgt gctggtgtga aagagagaat gatgtttcct gaagaatcta 283800 acattttttc tccatgtgta gaattcaatc aggcttatga tgagcaaaaa atgaaatagt 283860 tcccttctct ctgtagaaga aggtgatgat tttttttttt tgacttacag tgcatgcaac 283920 ccagatttaa atccaggaag aaacaaaatt ttgtgttcta taaaacattt tggaaaaaga 283980 aaagtgctac tgtaggtaac atgcacagtg gtgtcctggg acccccaggt caaatccttt 284040 gcatccactc ctgtgttttg ccacgccctc actccatcaa aagtctgcca ccaccatcct 284100 cctaaatgct gtaaatgaaa gtagcatagg gtgccaagac tcccaagata ctctccttta 284160 cttgtccaat cattatccca attccagcta aattccttaa cgggcataac tgcctaagtc 284220 aaatttaaat gtaaaaactt acatgtggcc agtggcattt tatcggacag cactgatcta 284280 aacaaatatc tgggattggt tttctcacct tgttcactgg gttggaggag atggtgaaga 284340 acagcctcaa atctcccagg acggacatta ttttcagaaa gggggcagat ggagggggaa 284400 ggaacagctc gtctatcatt ctttctctcc tacagtaatt atgccaagat acaaagttat 284460 aatttcttag agttcaacag gagtccaaag actcctggtc tttctttgtg tgagccagtt 284520 gatttgcatc ctttccaggc tacataaaca cagaagccca cagggcaatc cagctgtgtg 284580 tattacctga gccgtgggga gggatgctgt gtgatcacca ttacctgtga gaaacttgcc 284640 ttactatctt cttcctactg tttttgctgt acttacccag cagttgccaa ttagatgggc 284700 ctcacaagag taaaaatcgt caggtcaact gtggttacaa caagaatcct tgcatggaga 284760 tgccataatt ttagacgcac ctatcatggt ggaggaaagg tgacctttgg gatgattgtg 284820 tctcactgct ttacagttgg gaaagcaggt caaaagacaa taaattactt gtccaagatc 284880 ccatggtaag attgttccag aagcacatac ataagctgtc tgtactacac ctatcctgaa 284940 attgtgctct ctctgcaagg ccattttctc tagcaatttg caagaactgt aggaatgttc 285000 ttgctcaaat atgaagcatg gacgttcttt ttattgccct caaaataaaa tttttcttta 285060 tatcttctgt tactaccact gaacaaatgt tttccaccta ctcccaaagt aaaggaagat 285120 aaaaagagaa gttagaaata attgcattac aactaccact attatgacta ctatcatttc 285180 cgctaatgct acatgagaaa ttctttctat aaagtacatt atttaattat attaacagcc 285240 ctatgtggta ggtattgtta tccccaatag tcccccaaaa gaagcaaaga aacagaaaaa 285300 ttaagtaatt tatataagtt cccagagcag gtaagtagtg atgttggggt ttgatcccta 285360 aggtaagtat tcccaaagct cgttattttc caataatgtg tttgaatatg ttaaatacct 285420 tcacttcaga tctctccctt ctttcccatc ctcattctaa ttttgtagag tattggtccg 285480 tctttgaata tatagaaaaa cagttcttat taatatttta ctaaatgtaa tcaactgatg 285540 ctatgtattt ccagtttcaa atgagttgaa cataattcct ttaaaaagag tggcttgaaa 285600 agagtatcag aatgagtcaa gtgacctgca tttctcttcc gagctctatt ccaaacaaat 285660 cacaagcaac aataggttgt ttttgtacaa tttcagaatt tgtcaatatc tgtggtctca 285720 gttgaatgtt tctggaagcc gaatcagaca cacagcaatc aaaatcacca gggaatgctt 285780 tttcagcatt ttatacctgc attctccaat cctctaatcc ccaagtaact acagaacatc 285840 aaggacagtg ttggtgtgga atgtgacatg cacattttta aaccagtctc taaggaattc 285900 taatttacac ccttaacccc tggaaaagat aatcttcgag atttttaaaa gcctatttta 285960 atagacttgt gagcacttca agctctaagt cagaagataa aataatatat agaataagtg 286020 agcctttaca aagctcattt ttaccaaatt actgttcact ttaccaagtt accctactga 286080 tatatttaga tgagccatta cacattcatg cctctgctcc tctctgacta gtcacctgtg 286140 ccaggtgcac tcacaggttt tattgaagac ttggaagtgc tatatgaaat tctgaaatgt 286200 tctcaaagtg cctgtaaaat gttttctttt tcctgaaagc aaagatttgt agaaaggtca 286260 cttaactgtt ttcttacaga aagttgatat tcatgaatcc ataccagttc tggatgaaat 286320 aaacatcttg actgtcctat tgagaagaca tgatattggg gtgaagtcca aggcatgtct 286380 tcagttttgg ctttatattt aaagttataa accgcactca aaacagaaca aaatatgtat 286440 atgtatttga gaagttgtaa atgtagtaca aagaataata ataatgaaaa caaaaagcac 286500 tttaggctct aattcaacat tcgtggcata gtttataaca gtgaaaattg aaaacatatt 286560 aaatgctgaa cagaagataa gaaaactgtg gtaaatccac tagatggaat attatatagc 286620 catacacatt acagttatta cttctgtata ataatataaa atatcttata tcataatagt 286680 aagcaataaa aacatgagaa aaaattttat ttaccactta aataaaatta gcttgaatta 286740 catgtatgaa aaaagatcac ttaattatgg aaaataacat aactaacagg aacataatct 286800 taaggatgag tgttttgaat tggttctgga gtttctggaa ttgattctct aaattaatta 286860 gatttaaagt caccaatgac tctatttcca gcagtgaaga gagcactgat agtctataat 286920 gtgatacagc aatagagatg ggcaaagcat caccattggc tactcctaat cagatagcta 286980 tgagaggcca ggttctgggt gaccatatat ataatacttt ctaatctttt tgtcaaactg 287040 acagctgtaa tgatattcac tagttgctcc taattttgct agaggaagga aaagaagagc 287100 tcaggggttc aaattcccaa ctcaagaatt atataaatga cctgaaaatt tctaagtctt 287160 ccctgcagga aatctttatc ttctatagct gcagatctga gattgctcaa aaatcaaacc 287220 cagaatctca tcctgtgaga ggctgaatta taataccagt tgaatttcca acctcacggg 287280 gtgtttattg ttaaactagg gcattgattt gcaaggaatg ggatcctgag agttggaatg 287340 aagaaataag agaaggccct gatgagattg gggacactga tttcctcaac tctgataagt 287400 cttctttgcc agcaaaagct gttattccat ccccatctga gtagatcaac ctggctttgc 287460 ctaaggaaac tgtaatggcc tcccctgagg cagttgctat gcaaattgta gacctataag 287520 tatactcaag tcccagcagg cccctaaagg tgaggtacag aatgtgaccc atgaggaggt 287580 gtgccattct ccaaaacaaa caaacaaaca aacaaacaaa caaacaaaca ccttgatctt 287640 tttcaatata tatagacaga aattttagga atatatgtgg gaatgaatat ttatgtaaaa 287700 tggcagaaga aacataaatt tggacaaaac agacttatat tgacatgagt ccactaatta 287760 gagattctta tttaaatgtt gcagtttgga gaattagaag gggactctaa cagttagttg 287820 aagtggtaaa ctatattatg gcccaaaagg tggtccaccg tgaataaacc agaatgacat 287880 tctagtttaa gtgttgcagt ttggagaatt agaagtgggc tctaacagtt agttcaactg 287940 gtaaactaaa ttatagctca aaaggtggtc cactgtgaat gaaccaggtg gtacccctga 288000 ctgttcattt tacgtggaag gagaaatagc cagacatgta ttatatattg cttcatggcc 288060 atgaccaatg gtttgcctgc atggtaaagt acttggaaga aacatgattg gaaatgctgg 288120 acctgatttg gtatactgca aaggaagaca gtgaaggctt agggagatgg gaatgttagt 288180 tttttcactt acaacctact cacccacatc gggagggtcc agcagacata gctttcatca 288240 atactgtgag aaatacattt gtgagggagc cttagcctcc ttgaacagct ctgtgatcgc 288300 tctcctctac tgactagaac taacagtgga aactgatgtc actgatatgg gaagcctaaa 288360 tgcagtgaga acaattgcat ctaggagtgt caggggtcaa gtggcagcac tcaaccaaca 288420 aaaggtgggc atcgttgctg taatggacag cagggatcaa ctctccagct ctatgtcata 288480 gtagggttag cagggatctt ggtcaccttt ctctttcaga atacatcaca ctgtttcact 288540 acattgatga cattaggcgg attgtacctc gtgagcaaga agtagcaact acactagaca 288600 tactggcatt acttggagat attgtgggtt ccgttctaga ccaacatata aaagcaaata 288660 tttcaataaa aggagtcaca caaatttttg ggtttcccag tgcatataaa aattatattt 288720 actctttatc atcatctatt aaatatgtaa tagcattatg tctaaaaaac atacatacct 288780 aatgaaaaaa tatttcattc ctaaaacatg tccaaagtca caaagtgagc acatgctttt 288840 agagaaatga cattgataga cttgcctgat gcagggttgc cacaactctt gtatttgtaa 288900 aaagcacagt atttttcaag gtgcaataaa gtacagcaca ataagataaa gtatgcctgt 288960 actggtaaga catttgcatg ttagaggttc gtacataaat tcagaggcct ttccaaatca 289020 gcaaaatttc taggacttca gttgtatgga gtatgttaag agatcccttc taaggtgaag 289080 gttaagttgt tgtatcactc agtaaagacc ctagactatc aaacccagat gagtaatata 289140 ttgactccaa aattcagaaa ggcccataat aatgactagt gggactcttt gaattttgga 289200 gtcaatatat ttctcatctg ggtgtgatat tctaggatct taactgagtg acttgaaaat 289260 ctgctagttt tcagtgggtc ccagaagaag agaagtctat acaatagatt taggttgcca 289320 tgcaagctgc tctgcccttg ggtcatatga tgcagtagat ccaatggtgt ttgaagtaac 289380 agtggcatat atggatgcca tttggtgtca tttacaggcc cctataggta agttttatag 289440 caaagtcctg ccatcctctg cagataaata ctctcctttt gagaaacagc tttaccctgt 289500 tattggagct tagttgagac tgaatactta actatgggca accaagttac catgtgacct 289560 gagcttccca tcatgaagtg gatattttct gagccaccaa accttaaagt tgggtatgca 289620 caactgcact ccatcatcaa atggaagtgg tatagaccag atgggactca agcaagccct 289680 gaaggcacaa gtaacttaca tgaagaaatg gctcaaatac ccatggtttc taatcctgct 289740 atgctgcccc ttctctctcc tagccagcac ccatggcttc atggggagct ccctaaattt 289800 aggtgacaga ggaagtgaga atgcatgcct tgtttacaga tggttctgca caatatgcag 289860 gcaccatctg gaagtggaca gctgtaacac tacagtcctc ttctgaaata tccctgaagg 289920 gcaatggtga agggaaatcc tctgagaagg tagaactttg agcaatatac ctggttgtta 289980 attttgcttg gaaggagaaa tggccaaaca tgtgattata tattgatgca tggtcatggc 290040 caatggcttg actgcatggt aaaggatttg gagggaacat gattgaaaaa taggtgatag 290100 agaaatttgg aaaagaggta tatgaatata cctctctgaa tgggcaaaaa cgtgaagata 290160 tttgggtcca gtgtgaatgc tcatcaaagg gtgacctcag cagaggagta tttttatcat 290220 caaatggata gagtgaatca ttctgtggat accagtcagc ctcttttcat tgtcattaaa 290280 ccaatccacc cctgtcgtta ctcaaaaagc tcatgaaaaa agtggccatg gtgacagaaa 290340 tggaggttac gcatgagttc ggcaacaggc acttctactt accaaggcca acctgacccc 290400 agctgttgac aagtgcccaa cctgccagca gcagagacct acactaagtt cccagtatgg 290460 caccattccc cacaattata ggtcagctac ttggtggcag gttacttaca ttggactact 290520 tacattattg aaagggcagc attttgtcct ttctagaata aaagctttct ctgcatgcca 290580 atttcttttg tttgcttgca atgcttattc acagtgccct ggtggttact attattaact 290640 ttattctcta aacaaagaac ataaggtaca gagggtataa atcagctgcc ctttgctacc 290700 tggatatgga tagcaatttt ttcctttctt gtcaactctt cagcatctct cattaatctg 290760 tctcctcatg caagaacagc actcttttca attttgaaag tttatattgt gtttaatatc 290820 acctaggatt aatcttccct cattactctt atttttcata acttttcaag ccattcttgt 290880 agggttttag gatcctgtaa gcattttgaa aacaaatttt acttcagaaa catattggaa 290940 atgtactgca gaagcataaa tttgtatgtt aatagagatc atttaaatag ttttcttctt 291000 taaatacaat aaggcttccc atttgatgat gtctttgttt ttgtgtgcct atgatcatca 291060 atatcatttt caataccgac cctgtttcag tgcagacctc gtagataatt catgttgttt 291120 cccactacct ccttctcact gatactcatg atgtgaatgt ggtttttttc tcccattatt 291180 tcttttaacc acttaataag aaagttatta atttctatat gtttcatata tagcaactgt 291240 cctgagtttt ttgatcattt gaataaattt gctcatttga atctagcagg tgtttcacgt 291300 ataaggatat atctctgcaa atgatgacta ttctgccatt gttttctaat ttttgtattt 291360 ctgttttgtg tgatagcatt tacttgcaac tgcaggacca ggtgaaataa tagtggtgat 291420 aatgaaaacc cttgtcttct tcctgcctct aatgagaata attttaattc ctccttgtaa 291480 agcctgaggg gagcgtttga gtttgacata ttaaatgttt attcacacac atgcatgtgt 291540 ggataaagaa gggacagtaa tatctacctc atggggtgtt gtgaagatta agagacataa 291600 tgtatggaaa gcacttagaa cagtgcctac ctcgtagcaa actctttaca atgatgaatt 291660 tctatgttca tatgcaagag ctatccagct gtttactctg taaaaccgca gccataaatg 291720 ggtgagttaa tacacacaag acatttggaa tggttcctgg aacatagtaa gggctcaaga 291780 aatgtctaag ccattaatat actgcattat taaggcattt tgtcaagaac tgatgctgat 291840 ttttatcaaa aggttatgct gaggtttttc tacttttgat ccatcagtca aatgaattgg 291900 tctggaatat tttctagtgt taattcgttt gctttcgtgg aattagctcg tcttgcactt 291960 acattaaatc agctgccaga gtttgcaact atttcgttta caaaattttt aaattaatac 292020 tgaaataaaa atttgatctt agtttttttt agttgagctt tagtaggaac agttcgctaa 292080 cttcacagaa attattggaa tcttttccta aatagaaaaa taatacaatg caagagtata 292140 aataaattat atatgtatat atctaatatt tggctcccta agtatttaga aaatcaatat 292200 cttccttaaa gagttagtga aaatcccctg tgaaacaccc tggcctgctt attgtttttt 292260 gtcttatttt attctttggt agaagtagct tttgacactt ttaatgattt taattatttt 292320 acttgcttta tttgacagtt taggtttcta cctctttagg ttccctgcct catctggagt 292380 tagttttaat agtttatata ttccataatg agcatacatt gtattctttt cagtttattt 292440 ctatggagtt gaacaaagtg atgtcttgtg aatacaatat tttcatctgt atcttcatta 292500 ccttcctccc ataaatttgt attgttttat ttcactttgc tttttatttt ttcattaact 292560 ttggttaaat taggtaatgg tttattttcc cagagtttta tgtatttttt tcttttattt 292620 ttaatttatc agtattatct ccttcattat aacttatata ttttgttttt ccttttcctg 292680 atttttttgg atggggtggt atggaaacca gtagtttgca ttcttttcta tttactaagt 292740 ataagactag ccatgtttct ctgaatattt tcactgaacc actgatttta gttgcatact 292800 attttatgct aatttatttt tgcattttct gtaattttag ttttaatttt ctctttgatc 292860 aaaacttgct tacaaaagag ttttcattta tcgattggtt aattttttaa tatttaaatt 292920 ataaataagt tttttattaa catatctcac ggcagataaa tcagataatg ttttctgtat 292980 tatttctgct tttaattgtt tttgcttaca gtgcttttat ttttgcaaat gtttcagaca 293040 tccatgaaaa gaatatatat tctatgattt tagtcttagt ggttgctatg tacatagtta 293100 aatgtgcctt aataattagt ttaattataa cgatcttaag tgttttatta attagttttt 293160 ttttaagttt ttttcttgtt ctatactaaa tcactcacaa gctgtgaagg atgaattgaa 293220 gtccccctct actaaaagaa ttctatttct atttggtttt cttgccatgt tactcattcc 293280 tctcttaggt tatgttattg tggttactga ttttttttta agtttaatat tcaatttgga 293340 ttatccttgc ttgcttaata tattgccttt cttggtctca tttaattctt tatgtcctga 293400 aatattttta aaacaccttt attgagatat aattaatata caaagaactg tgcatattta 293460 aagtatacaa tttacaaaaa aattaattaa aggaattcaa atagaaaata aataaataaa 293520 attatacctg tttgcagatg tcatgattct ataaccagaa aactaaaaac accacacatg 293580 gacatgaaaa gtgtttgaga gaatacataa atacagttaa gttttgggtt acacagtaaa 293640 catataagaa ttagtgacat tacactaaca acaagccatc tgaaaaataa attgagaaaa 293700 caatcccatt tatagtagca taaaatagag tcaaatactt aaaagtaaac caaagatata 293760 aaatacttcc atactgaaac atacagaaca ctgatgaaag agattagagg agacacaaac 293820 aaatggagaa acaattttgt gttaatggat tggaagactt aatattgtta aaatgcccat 293880 actactccaa atattctaga tattcaattc tatctccacc aatcccaaat gctttatcta 293940 tagcaaaaga aaacacaatt ttaaaattta tacggaacca caaaagtcct agaatagcca 294000 aaacaatctt tgggaaaacc aataaagctg gagacattac acttcctgat ttcagaatat 294060 attacaaagc tgcagtgatt aaaacaatat aatactggca ttaggacaga catttagatc 294120 aatggaagag aatagaaagt tacagaaata aacccacata tatatggcca actgatcttt 294180 gacaaggctg ccgtcaatat acagtgctgg ggaaactaga tatcaacatg caaataaaaa 294240 aatctgactt tttaatattg aaatgccctt tctttttttg tttcccttta gaaacaaaaa 294300 gattttctat cattttcctt tcaatctttc ttaaacattt tgcttatatt ttttgaaaga 294360 atatttgagt tttgattttg tgacccaatc tttttattta aactattaat tgtcactgat 294420 tagcactttt tcttctctgg tttgtagata gttttgagtg tgataacatt atattaatta 294480 aagctattct ttctgatttt ggagcattta ttttgtttta tcttttactg tgctgtctgt 294540 gatggttttg ccaggggagt ttgcatatac tgagctaatt attaccttta tgacaatgag 294600 tttgtatgta tcacatttgt ctctctttct ttacacattt tctaatatat acttgccaga 294660 gataatagaa aaacacatgt caccactttg cctgcttcta cctttgaaac tcttcatctc 294720 taaattttag atgattatgt tttttctgta tgtttaggct tatgccctta tgtactcaat 294780 tattttattt ctttaaagta aattttttga cccctggcta taaaatatgg ggaaatctca 294840 taaaatctta caccttctct ttcccatcat actcccatta gttatacaat ttttatcgca 294900 tcagagttta taattttcac atttatattg aagacataat gctgcatttg tttcagcttt 294960 tattcttgag ttaaatggca tcaaccctca gcactggccc ttcatgacaa tttctccaac 295020 catctctctt tttttttgtt caagtttatt ccatcattgt ttccttaaga aggcgtcatt 295080 taaaatattt tctctgttct tggaaattct aaacaatgca acaatgtgtg tctgtcattt 295140 tcattctcaa actactatat gccttgtata aaattcttgg gacacttctg ctcactaagg 295200 aatttaggca ctcttctagt gttttccagc agtgctgcaa aagttagatt aaaatattct 295260 ttatttaatt taatgttcag taactttatt aggatatgtt tcagggttaa tcattatgtg 295320 tcatgttttc caggtctcaa tatacttagt gatatctaaa aacaagattt tttaatatct 295380 gagaaaaaca ttgaattaca ccttaatttc ctttgtttct tttctcctct tcagaaataa 295440 ctattttcct tcaaaaacaa gtattacaag aatctgtctt ctatagctat tattataatt 295500 tcagttcaga tcatatcttt tcagttcttt tatagcatat ttttcctttt gcttattttc 295560 ttttattaat taattaatta attttttttg acagagtctt gctctgtcaa ccaggctgga 295620 gtgcagtggc tcaatcttgg cttactgcaa cctctgcctc cccagttcaa gtgattctca 295680 tgcctcagcc tcccgaacaa ctgggaataa ggcaggtgtg tgccaccaag cccggctaat 295740 attttgggtt tttagttgag atgggatttt gctatgttgg ccaggctggt cttgaactcc 295800 tggcctcaag tgatgcaacc atctctgcct cccaaagtgc tgggattaga ggcatgagac 295860 actgcagcag gccatttatt ttcttttttt tagaaacaaa gtctcatttt gtcacccgga 295920 ctggagtaca gtggcgtgat catagtccac tgcagcctga gatcaagtga tcctgtcacc 295980 ttggccttcg aaaatactag aactacaggc atgagccatc tttgcttact tttcttaatc 296040 ccgtgctcca tatagcatcc tctgtttttc tgtaacgttt atttcccctc atattgtttc 296100 caaggttacc tttatttttg cattttgtat tgatcttatt tttatttcac cttttttttg 296160 gttctgccac tcatatttca agtccttgtt tcgcttcacc atttccctcc ttaaatgttg 296220 tttgtcagct ttgactcatt ggtttttttt gggagattac tccattgatg tttttctttt 296280 tccttttatt ttatggtaat ggcaacagtt tttatctatt caatgggaac attttttggg 296340 ggaagtgtgt gtgtgtgtaa attataatat atttttatag acccagtgct aatttttttt 296400 ttttcatttt gaatcaggtg atttttagtc aggctaacag atttttattc tctatgcaag 296460 ggagtcctta gttaactgag taatatggct gtaggctcat cacatccact gtgttctcac 296520 tcccccaaca ccttacccaa aggcggcttg ctgtaggtcc aagttgagtg tatgctgcct 296580 cctatgcccc tacctcctgt gcttattgtt ggtaccaaac aggttccctg gaagctctca 296640 ctttcattct cattctttca aaatgagctt tttaagtgtg gctcctgaac gtggtccatt 296700 gactttgtct tctacaaaga tgtgctttct acagactctg gaccacctgg gtggccgtga 296760 cagcactttc atcttgttct tcactgaatt acatatcttg tgttttctag ttttatgaaa 296820 aagtggcttt acactgttgc tttcattttt tttctattgt ttctatatca tatctgtgag 296880 agaattaggg aaaactgact ttagagtttt aaaatcaggt ggcctgttat tcttgtaact 296940 atgttaccgt aatcatattt caaaaaattg gcatttccaa aatgataatt aaacaaatat 297000 tttttccatg aatttagcaa tgtaatagct tcatggagat ttggaggcaa taagtggctc 297060 acttctttga aaacttacct tacaccttgt catgtgtagt gtgccaattt ttataagagt 297120 gggagaaaga atcaactgca aataaataaa aagaataaag agaagacatc aggtaatcat 297180 gaaacacctc ctaccaactt tataaaatta atcaggaaag aaggaaggac aagaaacaaa 297240 actgaacaca gcttgcagca cattcagcat tgatcaccag gtcagctgct ctccgaccta 297300 cttcctcata gttgtttcat gcctcttgcc tcagaatcac atagaccatg ttacaagatt 297360 atagttctta actgctctac agataacaac ttgaacatta tgagatggta agttttctat 297420 ttgagatatt cttgcatgtc ctgcatactg atgaaactac tgacattagc tggtctgaag 297480 gaccccacaa gaagctgacc aaggaatgca gtttacatat tctgataatt ttatctccct 297540 taccccaacc aatcaatgat ctgaattctc cagcccttca ttatccatga acccctttaa 297600 aaactccagc tacaaactcc ttggggagat ggatttgagg gtcttctccc atctctttgc 297660 ttggtgccct gtgaccatta aactctttct ccgctgcaaa cccttctggg tcagtataat 297720 tggtttgtta ctgcatatcg gacatatgaa cttgttgatc ctgtaagaaa ttatggcaag 297780 cctagtcagg agcagtttgt gggcatttgc ctaaggctca gtgttctgtc attattggga 297840 tggacccagg gataagccca aatggccact tagctccagt gaactagact gtctctgctg 297900 ccttgcctat caatggggca cataagtcac ttgtgcatag aaacagtttc tggttgtgaa 297960 aaacattgtt ggtaagtttt atttgtgcaa ctggcacccc ctttgtcttc tccctatttc 298020 ctggcctcct tggatgtctt gtgacctctc ctgaggtctt gtgaactcct tggatgttct 298080 gatgtctcat gtctcttctg atgtcttgtg gcctccttgg aggtcttgtg gattctcctg 298140 ggtttttgac gaccctcttt agtaatagga agggccttat ttgagggaat ttctcttaaa 298200 ttaaaaggat taaaaagggc agtgcttggg agaaatactc ttgatttctg aaatttggaa 298260 attgagtttg gaagtccttt tgtttgtctt tgtcctgtta tgtatgtttg tatgtgaaag 298320 agatccctga aagaattggt agtgaagctc ggcaggccta actcggggtt accatccact 298380 tttccacttt gcctcaagac cacctgctga actcctggtt ggaggtcatt ccccccgacc 298440 ttgagtaggt caaaggtgcc aaggctagct gaggcaaatg tgagccttgc taggtcaccc 298500 atgggtacta agtagagtga ttagtgtgta cattttgttg tgcatgcatt atttaggcca 298560 gaatgaaaaa tgttcatttg gtttctccaa gcagcccacc gggctttatg caaaattggg 298620 aagacaagag agatctttat taggtagtgc aataggtaac ttacccacta agggcacgaa 298680 ctcctgtgaa aaaactatgg aaaagtgcaa aggcatgcca ggttttctag gattccagtt 298740 ggttataaac catggctcag tcttgtgcac atttgaaatt gatgggcaaa ttacagtaaa 298800 gtaaaaattc agagctcaaa tgagtttatc tgaaaacata aaattaaaag ttctctgtct 298860 gtctttattt tcttttctgc ctgctttgta tctttcataa accactgagt ttgtattgct 298920 atctcatgac tagaatttca aagcaaaacc tatagcatct ttgtattgtc tgtatgtgca 298980 tttagataaa tttatatgta tgcacatgta ttgtgttata tatcatgttc atatggtact 299040 aaactggctt ataattaaaa gaacactcat aaataaagtt caaatatttt tcaagttcat 299100 gtgacttaaa tcattaatta aaaagctggc tttaaaatta ttgataaaat aaaaatagaa 299160 atgtctccag aattgtcagc atatattttt gtctgggctt actgatgatt ttatatgttc 299220 ctcttctaga tattttaagg tatcagattt tggcacaaag gttataagac tataaaccca 299280 tccaaaaaca gaatggtctt cgttggtgta attttttgac aaataagact aatttaatgt 299340 tttttgttca atgaaaacag ctaaatcatc taagttattg gcaaaagtac tcataagttt 299400 aagtttctta cttaggtgaa ctaacacagg ctataaaaat gtcaaacaga aataaattta 299460 aatgatgact agctttgtct aatatctcag ttatcataac taatctagat aaactgctaa 299520 aaataaatga gtaaatatga atgggctaaa tacttaaagg taaacttttt gtttgtttaa 299580 aatcttaaaa ttattttgaa tgcttgttag atatctgggt aattttcagt taagaaacag 299640 ttacgatata gggaaacaag tttctaaaca ttgttaaatc atttcaacta taaaacacta 299700 acatctaaca aacagttcag gatttcttgc ttcctaggtt ttcactaaaa cttaaggtta 299760 cctgaaataa gatttctagt aaatatatag ttctgcatgt aaaacgtgtc aaaaaagatg 299820 tgtttctcat tagaaaaaaa attaaaaaaa tataaagttg ggtttttatt aagaaaaaga 299880 ataattttgt ctaattcaga agttatctga agattgattc aaattatgaa cttgaaaaga 299940 ttatgaaaca aggtaaaaag gccagtaagt agaggagaaa tatgtaaaaa caattacaaa 300000 tataaaaata tatttttcat aaggagggtt ataaaaacaa agataatact tttatatgaa 300060 aaaatatttt gtgtgatata tttttgttct aaaataaaat gactagttat ttagaaaaaa 300120 aaagaaagtt cagacatgtc atagatggcc tgtataagtt gtgacaagac tcatgaaagg 300180 gaatttatga aagaaattta gtatttgatt aggttgacta taattgaaaa tattattcat 300240 aatagtcctt ctaaagattg gttatcctct gataaaacaa gatttcctta aggtatgaat 300300 ttactctaaa taaaattaca agaggtggct gggcacagtg gctcacgcct gtaatcccag 300360 cactttggga ggctgaggcg ggaggatcac gaggtcagga gatcaggacc atcttggcta 300420 acatggtgaa accccgtctc tactaaaaat acaaaaaaca aaaaaaaaat tagccaggcg 300480 cgatggcggg tgcctgcagt cccagctact cgggaggctg aggcaggaga atggcgtcaa 300540 cccgggaggc ggagcttgca gtgagccgag attgcaccac tgcagtccag cctggacgaa 300600 agagcaagac tccgtctcaa aaaaaaaaaa aaaaaaaaaa aaaaattaca agaggtttac 300660 cttttaattg tgttacctgt ttcattttga aaactcagat ttatatctca gaagttcgac 300720 gtttgctgtt tctcattgtt ttcacccttt tctccctttg agaaggccag agatgaaaac 300780 tctcttcttc atttttattt tattttactt tatttatttt attttatttt attttatttt 300840 attttatttt atattttatt ttattgccag ctcctgtaac attctgtctc tgtttttcac 300900 tttactgcta tggcctgaca ataaaatatt tatcttaaag ctctagaaaa gcaatgtttt 300960 tctttagaat aatttgattc tgtatacttg acttttcttg ctatgtctgg atttttccat 301020 gtaacagaaa acttctcaag gtgttactag gagtcatgca ttactagttt tctagttttt 301080 tgtttcctct ataatataat ttataaccat aatcctggac acattcttcc tgtattggat 301140 tgattcaagt gcccttttca tcagggttga ctttaaggtt ctctaaatgg gtttcccata 301200 aggagaagca atcacacttc actctgcagg tggttttcct tggtgttttt gataacaggc 301260 ctaagaagca agattttata ttttatcaat ataattccta tgttgttagt tttttgatta 301320 cttaggaaca ttcagcttta agaaggaaag tttttacttc tgtataactt tctgtagtgc 301380 ttttaaagtc ttgattatca ctttggttaa attaataact attattttac aatgacctgt 301440 gattctgttt tgatcaaatg ttttggcctt ttaacatctt tgatatacat cctcaaaatc 301500 aaattctaaa ttaagtctct gacttagact tattgctgat acttatcaaa gctgtaaaaa 301560 ctgatccctg caagatttta gcatcttttt acagcttcca gtcaaaccat gaactccagc 301620 atcaccaact ccagcctgat aattacatgt actgaaagag atatccattg aaagactccc 301680 tcgacccccc ctttaaaggg actttcatca ggtgctatta attaatcctt gtactgttaa 301740 gttaaagggt tttgattcct gggtgcacat atctcatctg aaaaaggcac caactcctac 301800 taattcttaa aatattgata ctattatctg acaccatact caggttaaca aaagccttgt 301860 cttcagaccc agaagaaagg tagcatgaaa atgatctgct tttgtgagac ataagactag 301920 aaattaaaac tattcaatct ctctaggctc agtgactact gcaggagaga tgggcatgtg 301980 agattgtaag ggcctgtttt gagggataca attagttcag atgctccaaa tcaaggatgg 302040 cacagagtta cctaaacagc caacaagttg aggaattttg ccactctgaa ttccttaact 302100 caaaagggtt taaccaaatg cttatgtttc gtattgctaa atggctacaa gtcagtatct 302160 aagaccagaa ttcatttcta taaccttact ttttggctct tatatgctga aaaggttttt 302220 taagcattat tgagtgtctg cccacttcca ttcccatctg gcccagaatg tttaattgac 302280 tacatgtctt ttgactgaaa gtcatttggc cataggggtc tcaccaaggg acaagatgga 302340 cccaaagcag gtgaccacac caacctgaca atgatatggc acaaaataaa aagctttgca 302400 atccatgctg cttctggcat atcttgacca aaaatactga acccagaact ttttggggaa 302460 atagatttga gagtctcctc ccatctcttc acttggcacc ctatgatcac ggaactcttt 302520 cctgctgcaa atcctgctaa ctcagtgtaa ttgatcagtg ggcaaacaaa cctgttggtc 302580 ctataatagt caaagtcctg tgatgcaaat aaaccttaat ggagagacag ggttagtttg 302640 tgtttggtgg tttaagaggt tgtcatcaaa gagtgagtaa ttaagatggg cattgaatgc 302700 taagagagag gcatttatgt gcagttgttg gggaggaaca ttctaaaaat aaggcccagc 302760 aagtgcaaag tcccaacttt ggaaagataa aagctacttg ttttatggga taaaagaaaa 302820 ggaaaaaaat acacataatg agagagatct gcaggaacca ggtagagtca agttgtgtag 302880 gcctgagtca aggacttggg cttcattaaa gatttttgag aaaagaaaaa cacttcttac 302940 aatgaaatca gatgacttca actgatattc ttaatgatat actgtatata aaaatataga 303000 cattcttgat tggtcaggta ctaataaaat gttttccaca catacagttt tgtgaatttc 303060 agttacaact gaaaacctgt ggattcccct gacctcacgt gctcttccat ctagagagtc 303120 tgaattgtaa aggagaggtc caaaaccagc attgatgaag acctaaatga cctatcactc 303180 atgaaggctt aggtctattg tcaaaggctg acactctagc ctgatggagt gcttccttga 303240 aacaggttct tacaaacatt gtctgattta attttcacaa caatccattt gaaataggtt 303300 taaattgctt ctattttaca gttgaagaaa cacactttaa aaggtttaag gaattttcct 303360 gaggttactc agctagtaag tggtagagac caaaaaaaga acttgggtct gttcattgcc 303420 cagcctgggc tctcccgcaa agcctgccac ccacaaggct tgagatggag agaatctggg 303480 gtaggaaata cctttctgtt tttttcaaaa ccactccctg ttggcagaac tctccttaag 303540 ctacgcaaga gggttgtccg gttaagccat ttatctttct ctatcagaga gcaggctctc 303600 ttttctcata gctgtgtagt cttagcagtc agaattgata acagctgctg gacacctgag 303660 ctgtattatt ttgccaggag ataacagagt gaatgacttg tagcagactc agaacactga 303720 tgagttcaag gcccacagta gagattgtga aatgtaattc ccagataatt caaggggaag 303780 agaagctaaa caaatctcgg tttcactctt cgaatttgta ctctgagaac aaattgagaa 303840 atctgagaag aaaagtcgtc atatttgaag tgcttcagag aaatttttgt cttctttttc 303900 ctttactctt tggggcttga ataccaacaa gactcatttt tgaaattaga atttctcttc 303960 catagggagt gagatttaac ttaagataaa atttgatgct tccttcagag agagcaaatg 304020 tcttagatac aggtcaggga agcttttgct ggccactcat gtgcatggat ctcattcttc 304080 tgctttgcct ttttagtaaa tgggtggcgg gaatgtaggg gttttttgat aattgaaacg 304140 aggtgtttcc tttcttgcaa agtgctaaat gcattaagta cttttgcaaa ggagatagta 304200 cgtgcctcaa tttagacaga aattttactt taaagaagtt aattcgtgat gaaatgaggg 304260 tctatcatgt gccatgtgtt gaaacttagg gatgagtcag atgctggtcc tgctctcacc 304320 aggttcacct tcaccttggg agacagacgt gtagccaagt aactccagtg tgcaatgagt 304380 gaggctccat acactttctt gaatttttag gagtcccctc ctatctttca tcattactcc 304440 atcttgttag aaaggaggca tagctgaata tcattttaga agagagactt gccagtggat 304500 gtatgacgat ttatatggag ttactaaggg gttcttagtg ggcttttgag acagatctga 304560 aggtaaattc taatgcttct gcttcttgtc cctggcacct tgcatatagt tcatatttga 304620 ctcctcaggg agatgagaag ggattaaagg gaagaacaca gactttgtga ctagttccag 304680 cacagtagcc gccagtactc ttagttatgt ggctgtctag aactgacttt gcttattaca 304740 tcaggcactt ctgtgacttt ctcagggacc ccatactagg aaattccagt ggcaggtcct 304800 gtgatatggg tgatgttttc tcctagaagg ccacataatg attctgtacc ccaacccctg 304860 ctataaccca ttctgaagtg gccccattct aagagcctca ccaggtagct cttacaggtg 304920 aagttcattt ggacttgcat caaagctgga actttcctac atgcctcaca tcaggttcac 304980 ccttttcacg gctgttagta gaagtcaatt taagtcttaa tccaacccct tatctctctg 305040 tcatgtcatg ggcagtcaat agttacagtc taaattttgc agtttttagc tcactggtta 305100 ataaagacat cacattaggc tgggtgcaat ggctcatgcc tgtaatccca gcactttggg 305160 aggccgaggt gggtggatca cctgaggtca ggagttcgag accagactga ccgacatgga 305220 gaaaccctgt ctctactaaa aaaaaaaaaa aaaaaaatat atatatatat atataaatta 305280 gctgggtgtg gtggctcatg cccataatcc tagctacttg ggaggctgag gcaggagaat 305340 ggcttgaacc tgggaagtgg aggttgcggt gagccgagat cgtgccattg cactcctgcc 305400 tgggcaacaa gagtgaaact ctatctcaaa aaaaaaaaaa aaaaaaaaat gacatcacat 305460 cagatgtaaa agactcaaga cacattcaat atgtgtagga tcacaaaaca aacacaacaa 305520 caataacaac aacagcaaaa tacagagtct attaaagaca aaacagcaga aacaaagtga 305580 aaaatacata catatgcagt atggaaaaga tcaatgaaaa gcccagagag taataaatat 305640 tattttccag gcagttttgg ctccacagga catgcatcaa tgtccggaga tgtttttggt 305700 tgtcacaact gaaagggaat ttgctcctgg tatctaatag gtaaaagcca gagatgctgc 305760 taaacatcta atacacagga cacatctccc atccacctac tcacccaccc acaacaaata 305820 attaccctga cccaaatgtc aatcatgctt aggggaaaaa ccctagtgta gaggaattta 305880 ataagaacat gagtgaataa aacaatgcaa taataaaatg acaaaacaag agaacgaaga 305940 acgggtaata gggagataag gaggaacatt aagaatccct acaataacat tgctagaata 306000 aaatagacct ggttgaaaaa cagatgccta ctttcatcat tttattttat ttgagacaga 306060 gtctcactct gtctctcagg ctggagtgct gtggtgctat tctagctcac tgcagcctca 306120 acctcctggt ctcaaatgat tttttatttt taaggttgga tgtgattgga catgatcgca 306180 cattgatttt cccacctgca tcaccaccac taacttggaa acatgagtct tgtcattttt 306240 ctcaaggact cacttctaca aatttctgag tgaggccttg ggaacaaatc cagtccctca 306300 ggacactagg tctgggaccc ccaaactttc cctgactctc taacaagtca agggaaaaaa 306360 ataatacaat attaagggtt aaactacttt tcattcccaa taggaaatgt tatttttctc 306420 atcttgtggc tattggggtt ttgagcacca gcaagggaca cttaataagt tgtagatgca 306480 tcatgtgaag gggcagtaat aattatttca tctgaaataa accagagtgg gcatgtgtct 306540 gctcatagat ggaaaagtat gcattttgca cttgggtaac agttggcaac tctgactaga 306600 aaaccttttt tgactatggc aagcatcctt cttacttgga ggaaaaattt atgcaaaaga 306660 cctggcaaag ttcctggaac atatagtgtg cctgatcaat gaacatatta ctttctcacc 306720 ttaaacaagt ttactgtatt tcattattta agaaaaagcg ggccgggtgc aatggctcac 306780 gcctgtaatc ccagcacttt gggaggccaa gttgggcgga tcacttaagg tcaggagttc 306840 aagaccagtt tggccaacat ggtgaaaccc cgcctctact aaaaatacaa aaattagttg 306900 ggtgtggtgg cacacacctg taacttggga ggctgaggca tgagaatcac ttgaacttgg 306960 gaggtggagg ttgcagtgag ccaagatcac accactcact gcactccagc ctgggctaca 307020 gagtgagacg ccatattcaa aaaaaaaaaa aaaaaaaaaa aaagagagag agaaagaaaa 307080 gactcatatt caaatcttgt cttacttaat atacttttcc taagtgtaca ctcaactcct 307140 aactctttaa taagactaga tctctttaaa gaagataaac aaacagcaaa gcaatatgta 307200 tgcagttaat cctcaggaaa ggataagata ggaagtaaat ggaaatgata tcttgaagca 307260 aatccttctt agactccttc gctgcctctc agaagaatgc taaagtgtga cattttttct 307320 gatcacactt aatttatatt gcatcactat tggtgtagcc attctttaat tgaatttatt 307380 tagtctcttc ttcttgcact ttgataggcg aaaataatac agcggggacc aaactgcagt 307440 tgtttattca aggcacttaa ggggcaaata agttgataat tatagtattg tttgataatg 307500 ataaattatg cttaatgaaa aatgcaaatt aagtataatg ataaattatg cttaaataca 307560 gatgagcaca tagggagagt tcccacaaat tattgggcca cagaaactaa cattttccgg 307620 agaaatatac atcttgtgga ggcctgaagg gtgaatagga gttgtcagga ggcaaaagag 307680 gaaaaaccca tggagaggaa ggattaacat gttcaaaagt ccagcagtaa gtaagagcat 307740 agtacggctt tccagtgttt ctttatgcaa atgtaaacag atacacatat acccttctta 307800 cctactcaaa agatagtgaa ctatgcacac tccttttagc cttgctttat tcaaataaca 307860 atatattttg cagaccttcc catgtaggta cttaactttc cagctgctta tgattttaat 307920 gagtacagcg gaattaaacc agactcaact gatggtcact tggatgattt cttgcaataa 307980 tcttgcaaaa atgttgctat gaataaaatt gaaatagttt cctagcttgt catttgtctt 308040 ttacatatgt tttggggcct aggcataaag gtgtttattt atacatagta aaaaaatact 308100 ttattttatg gcttgaaatg cctcatttgt tagatataaa attcttataa tatctgaatc 308160 tatttctaaa ctttctttct catttccttc gtttgacttt ctattcattt gccagcacta 308220 caaggtgaaa ttcttgagtg tttatagtat atttaatatc ttttaaggct atatctcctt 308280 attgcctttt tacttttagt gttattatgg tcatattgtt catttttttt acataagatt 308340 tagaatcagc atatctaatc ctgaagtaaa tcctgattat tttcaatggc ttaatgttaa 308400 tttatattac agagagagaa ttgacatctt tatgagactg agtcattctt ttgaaaacat 308460 gttatatatt tctacttgtc atgtctattt ttgtgttcct tgaggacttc taaaaaagtt 308520 tctgcataaa gttgttcttt gcacatatct tgttatgttt attcctatgc ttgtttttgt 308580 ctcttattaa aagtgaagtc ttctttttca ttatgtctcc ttttagattt tttttttaat 308640 atgagggcca ttgattcttc tttattagtt ctatatcctg ctatctcatt gtttttagta 308700 gttgttaaaa tttttacaaa ctctctaagg cctggtaaga cagttacatc atctacaaac 308760 tatgtgtgag ggtgttttaa cctccttcct accactttta aacgaatata ttttactctt 308820 ctgatacatt gctagtgcct ttagcagaaa agtttgataa taattgtgaa agctgagaga 308880 gtgtcttgtt cttgacttta ataattgact atgtcacaaa gtatgtccct gcattaatct 308940 agatttgtgt atgtgtgtgt gtgtatacac aagcagtcac atgtaagtat gtatgtaatc 309000 attcatttcc atcatgttgc atttgttgtt gttgttgttg gatgaagaat gtagctgaaa 309060 gttgtcaagt acctttcaat ttctgtagag atgctcatat aatttctata attaagtaaa 309120 ataacataat taattatatt aatatatttg ttaatagtga atcattcttg aattcttagc 309180 atgaggttac ataaaagaga tgagtcttgc agttttgttt ttctgcaatc attatttttg 309240 gaatcaatat ttcgtcatta caataattca gaaatggccc ttttgtcctc taatctctgg 309300 aacagtttaa ctagtatggg aattgtggtt tgttcagtag gattctccta tgaaaccatg 309360 tatttttgat attaccttag cagtacacca ttgtcagagt tttctccatt tttcgtggaa 309420 attaatctat tttcgtttct attcctatga agtcagattt tggtaaataa tattttgtca 309480 aaatagttta catttcattt agttttctat ttatttgcct tgagtttacc aaaacgaaac 309540 tttctaactt aaaaaaaaag ttgttatttt tatatcagtg attgttttcc ccttatcata 309600 accgtgtttg tttcttttgt gttttttctc tttttttctc aggtaattta atcttttatc 309660 aattttggag ttcttcaaag aagtaatttg tttatttatt gctgaatttt agcttgaagt 309720 attctttctt ttcttttcca ttaattggtt atttttcaac cttttgttct aatttttagt 309780 ttgatgctta atttgttaac ttttattatt ttttgtatat tttatgaaga tttaaaacaa 309840 tatttcactt gagtatttgt tttgctgcat cttgattctg aactatagtg ttttcactat 309900 tactgttttc cagaaatttt gcaattttga tttgtatttc tctttttacc taaaagttgc 309960 tgataacaga ctaagttttt catgacgatc aaatattagg tttatatgta taatataaac 310020 atcaggattt taaacacatg agaaaactta ctctctgcat agcagagaat aaatcagagg 310080 ggaccaggct gtagaaccct ctttgtatgt gaaatatgct tatgttcaaa gataaagttt 310140 aggttgcctg agattgagca gtagtttggg caacaacaat aaaacaagca gatggatttg 310200 agatatataa agggagtata ataaactttt catggtgatt cattaaaagt gctacctgaa 310260 gctgaggaaa gagttaaggc caacaaagtt cagacatggg caactccatg ggtggtagag 310320 ctacttactg aggcaggaac tgatggacca agaacaggtt tggaaagaaa gacatgaaga 310380 ggtgtgagag tttggatttt agatcctgag aagcatacaa gcaatggtgt tatcaaagca 310440 gttggatata taaaagactg tatggtgaga gacaaattgt gaagtcatta gtactgaggt 310500 gataatttca tatatagaaa cagctgatgg aagaagttta aagtaacaag aaaaaaagca 310560 ttgaaaaggg aatcctgagt gctccaggca tttatgggac aagcagaaga agggtaatct 310620 ttgatagatg atgagaagga gccagtctgt catcccactg aattgtggct gccttgagga 310680 aaacatagaa tctgaattat ggaagactgc tgaaaaagta ttaattgcac ataaatgaat 310740 gcatgggcaa agcaattttc caaaactgat acagattatt aaaactatta tactcattta 310800 attctagaaa actgcatcat gaaataagtg gtggttgagc tggcacttct aggaatggac 310860 aaacctctgt gtagaaccca tggctccatc actggagtcc gtattcagca gtaaaacagc 310920 ctctctcagt catgcttgct gtgagttaca cccagccagc aggatcatct tgacagctag 310980 ctatttaact aagttatcag taagcaggta atagtccctc agttcagtca aaacagtcaa 311040 attagttgta cctgtagaca tagcctttct ttgccaacat ttatgacacg gacaggaatg 311100 aattaggaaa tagaacaata gctccctgta tgtgaaagat gtgtcgtctg tctaaagaga 311160 aaacacattg tgtttattga gtgggaattg tcatggaagc tttgcatagc tttaaaaaaa 311220 aaaacacaat atgctaactt cattccagtg attgaagcac acaattttgg aaggttttat 311280 ggaaagaaag aggaaaaata aatagagaag ctgaagtccg aaataaatgt gtgagtcagc 311340 cctcatccaa atacaattat taccttcacg ctttgccctg ttttgtttga cctaggaaaa 311400 tatattcaat gggatttcaa agaaaaatca aataattttt ttttcaaaca ctgtggcaaa 311460 aacccatctg gccaaaattt tacataattg cattctcaat gcaacccaaa tacatatttt 311520 taaaaaagcg gccaggtgca gtggctttca catgtaatcc taacactttg ggaggccaag 311580 gcgggcagat catgagctca agagatcaag accatcctgg ccaacatgtt gaaaccccgt 311640 ctctactaaa tatacaaaaa gtagctgggc atggtggtgt gcgcctgtag tcccagctac 311700 ttgggaggct gaggcgggag aatcatttga ccctggagac gcaggttgca gtgaactgaa 311760 atcgcgccgc tgcactccag cctggctaca gagtgaccct ctgtctcaaa aaaaaaaaaa 311820 aaagaagcaa aaaaaaaaaa aaaaagaaaa caatcgatta tatacacaca atgctgtgtt 311880 cttaggaatc cactgtccta ttctctgtca gtgaaaataa aaacacaaac acaaaagcac 311940 tctacccatt taaagctgcc tgattatttc ccctctgaca aactgctgcc cctttgagat 312000 agctgttaaa tctcatggcc tttatctttt gacattttat catattttgc ctaaggagat 312060 ttatagaatt gtgctatgat tttgtgccat gctttaactg taatgttgtg ctgtggtttg 312120 gctccaacac ttgatttcct cctatgtctc ttctatgcat gaactcaggc tgttctgcac 312180 attaaaaggg cccagttatt tattggatga gtaactgttg ctttcttcct ctcctccctc 312240 tctctcttcc ttcccgccct actttctgta tacttatctc taaacaaatg gtttatggat 312300 ctctgcccac ccctctgcat gggtgacttc cacgggcagg gaccgtgcag tactttggtc 312360 ttcctgccat gtttcccaat taaatctgtg actttttctt tcccttggtg ccatccaggg 312420 ctgcagtcag ttaactaaaa ttcaggacca gcgtgtggtg gactgcttcg tttatagaca 312480 tggggaattc aatctcaaag tacagtttca gttttaattg ctaatattaa gtggtttttg 312540 aatttctaat gagtacctaa ttagagcaaa tgttttcctt actaacaagt aattatagca 312600 ttccaaacac gtttacttta attaaacaaa actggttgac taattacgaa tggcaaggca 312660 ggacacagcg gatttctatc ttcaaggaac tccagcagac attcttgtgt gggtaactac 312720 acattaaagc tcacttttgg gtgctctcag ggcggctcct gatagtacca gttacgcaaa 312780 gcgaagttgt tcaactggag gctcagtgcc tcctccatgt aatagagaca tctccgtggg 312840 gttcttctca actcttttca aaatttcccc attgaacgaa aacaaattat gcctgagtgc 312900 atgtggtggt tgcctgaaac agctgtcaga atgtaaagag tttttaaaga ctcaagttta 312960 atttaaaaat tatataccat ttgcattata tgcaataata acctgtttta attctagttt 313020 ttaaagaaac attttcctca acccctcaat cctcccaaag ataacaaaca ttcaactgga 313080 gcttactgac ctcctagcta tagttgtggt ttgagagcag gaatttcggc gactgaatgc 313140 aaaatccatt cttttaaagc tatggtatat gcctgtgggg tatactccaa agtatggatt 313200 ctgtttggcc atcagtattg tggatggcta tacttcagtt tcctcttatt gatgttacat 313260 attgaactac tgctgaaatt tggaattaga ctctgaaatg ttactattgg cctttatgca 313320 gtatctggca actgtgaaaa cagataatta ggtatttgtt cacacttgtc tctttgaatg 313380 aagctgtcat tgtagtctga gtagggagtc acttaaagga aatgtactcc taaccctttg 313440 aagaggccaa tcatggtaca caaaccacat gagtcaccaa agctgatatg gacacatcca 313500 tctgtatgtg cttgggtaaa aagttcatcc gggagagatg tgactgagga aagatgatca 313560 tgaaaagcag ttgtgagaga atgcttctgg ggaaaatgga tttctcaagt cctgaggcca 313620 ggttcacaac ttagtaagaa aaagagaata ttcacacaca ggaattgact tgcatgatgg 313680 cattgagcgg aactggttat ggtgtaggtc aacaagtagg aggaacaaaa tagtacggaa 313740 gatgaaaatc aaagatgaaa atggaagaga ggtagaacat agagcttaac agagcccagg 313800 cctaaaattt gaggttgtac aaaaccatgc ctgagtgttt cattgtgtta cttaacacat 313860 gcccgtccat gcattctatg agtatttcac tgcccttttt caggtgctgg tcatgtaggg 313920 ataatgacat attcataaac gggtgtaata tgaggtaaga aacgacctgc cttataaaag 313980 agaagcaggc aaatgcaata ggtgttcaga gatcccagcc tggccttgct tctcagcttc 314040 tttgcctgct caattctgtt ctgtgactct cctcagagtg ggttcatgct gattgttttc 314100 actagtcctg cttcgccttt tcccttaaaa tccacatcac caactcagag tgttagaatc 314160 tttttttttt tttttttgag atggagtctg gctctgtcac ccaggctgga gtgctgtggt 314220 gcgaactctg ctcactgcaa gctccgcctc ccagggtcac accattctcc tgcctcagcc 314280 tcccgagtag ctgggactac aggtgcatgc caccatgcgt ggctaatttt ttgtattttt 314340 ggtagagacg gggtttcacc atgttagcca ggatggtcta gatcttctga cctcgtgatc 314400 ctcccacgtt ggcctcccaa agtgctggga ttacaggcgt gagccccttg tcaggcagtg 314460 ttggaatctt accccagtga aatacaatag tgacccatgg gccctgaaca ctcacatgtg 314520 cttagcactg ttctaagggc tttttagata ttaatgaatc caatttgacc aagggtgaac 314580 agctactaca ccaaagagct agtatctgac ccaaagaggc tcatttccta gccgaagtct 314640 aaaaacaaac aaacaaacaa acaaaaactc catagtatct atttgatgcc tcctttgtta 314700 tcatgaagta tctctgattt atccatatgg aggggtctct gtctcctctg aactcacaaa 314760 gcattcttta tgcctctcat caaatacctt tctcactatc attctacatt tggggagggg 314820 gctcttggaa gtatgactca tggagttttc attgttttaa atacattttg aacttttgaa 314880 gatgttttag cagaaaattt tagagtaata tcaataaata tttgtaatgg aatgattgat 314940 cctatatcta acatacaaag aaaatgccta aatagtctca gattctcatt ttaatgtttt 315000 ttaattttat atttttatat ttttgttggt ccttggaatg ataggactta gggatttttt 315060 tccttggctg atcttgcttt gaaggcaaag ttataaaaat atactttgaa tgatttgtga 315120 ttaatttatt ttagtataac ttttttcttt tcttttcttt ttttttttaa taaacagagg 315180 ctaagcaaat ctttggagat tttctctagt tccctcttag ttctcttctg tggtcctctc 315240 caatgtccta gcgtttgcta tttacttggc tagagcctcc agtctggtat ctgatccagg 315300 cctgcctttc ctaaaaggcc ctactatgct tagctctttt taaaaagcca gctttaaagc 315360 ttttattagt attctaacag ataaatttat acttaagtat taataattgc ccacttctca 315420 ttattattat tattgttgca attgttatct cagacagtta ggaataatgt ttggaatggc 315480 aataatggta ttctttagtt agagatagta ctcctgcttg atacttaaag tgcctcataa 315540 aattcaaagg aaatcagaca tccaatttct tactttagtc gatgtaacta ttgttcactt 315600 aaaacactca tgagttcttt tcatgagtcc taactcagag gaaacttcct agagctcatt 315660 aaaactttag gctctgttta ggtgacctat aggctgtgtt ggcatataat gattttgtct 315720 tttgagctcc aaagatatac cattaatcta atgttatcaa gatttgaaaa atggatttat 315780 aaaaagtaaa cacagctgag cgcagtggct cacacctata atcccagcac tttgggaggc 315840 caaggtgggt ggatcatgag gtcaggagtt tgagaccagc ctgtccaaca tggtgaaacc 315900 ccgtctctac taaaaataga aaaattagcc gggggtgatg gtggccgcct gtaatctcag 315960 ctacttggga agctgaggca gagaactgct tgaacccagg aggcagaggt ttcagtgagc 316020 tgagatcacg cctctgcact ccagcctggg tgacagagcg agactctgtc tgaaaaaaaa 316080 aaaaaaaagt aaccacaagg gtattattct cctgaagaat cctttgcttt ctgatatgat 316140 aacatttgct tatcagaatt cagtttctgg tatgatggaa taaattacaa agtcactgga 316200 caaattagag ggtaaattct taaaaatgtg aattgcaagg tgtagatttc aagtagcaca 316260 gaacccagat gaatttcatc cactacctgc attataatca ggaacagaaa aatggagttt 316320 actttaacac tatgttactt gagtgcaaaa tcccagctcc acaaaactct gatgtcctga 316380 aatttgttca catgccttag ttgagctaat tactagaatg agtttgggca agttactttc 316440 ccctcagcag gcttcacttt tcctcactgt aaaatgaaag tgtgggtctg tgaatctctg 316500 agatacttcc gattttgtgc attagtgatt ccaagtgaga tttccttcag ctagcatgcc 316560 attaaatgct acatttttat ttgctttctg atttccctct tttcatttat gaaaagagct 316620 cacaaaacct ttttcctgtc tatttgctct tggaaaatta tgggctcttg gaagttttca 316680 atttaaatta tatttacttt tcattctcac tccgtcagag gcatgtgcat atgaaaatgt 316740 ttgtcttcca tccataccct actgactcat taggaacaat cagagtgagc tgttcttttt 316800 cccctgctaa taataacaaa ggaaccaaac atatatagat gagattgtat cttcaaagga 316860 aatttacgtc ggatttgata tttattttca caattatatt ctgacgtaga aagcgtcaac 316920 accaatttcc caaatgagaa actctattat agaattgaaa tgggagctac tctgcaaaac 316980 ccctaggtgc catgggtaca atcaaccatg gttatgtgcc ttccccacag ccatttaccc 317040 ttaccctgtc aaaagaaaaa ctgttgtttt cctatgtact caaaatactt ctgacaccaa 317100 acatgtgggt tttctaacca agcaattttc catttctctg tggacaccaa ccgagtgttc 317160 tacaatttaa ctaaattctg aaactaactc cctggagtca gtgtgggcct acagtttaag 317220 tgctcattcc cacaaggctg cccaccactt cagataccaa ttgcaaggcc cagattgtta 317280 cctgtaattc tcataaactg gctataaata tgaggctcct ctaacccctt attgtttgat 317340 agttggctat aaacactcac aaaacccaag aaatggctta tttaggttta ctggcttact 317400 ataaaggata cagacaaaca atcaaacgaa agagatgcac agatcaagat gtagggtgca 317460 gcacagagct tttatccctc tcccagtgtg cactctctca gcactgacgt gttcatcaac 317520 ctaggagccc tctgaactcc attgtttggg ttttcttttg aggtgtcatg acataggcaa 317580 gattggttaa atcactggcc ttgtgattga gctcaatctc cagccgctct tcccttcctg 317640 agggaggtta gaggtggggc tgaaaatttc aatcctctga ttacatggtt ggttcctctg 317700 gcaaccacgc ctcattttcc aagagccatc tcaatctcag gtatgtttga aaaggactta 317760 ttatgaaaaa caatagacgc ttccctcaca ctgatcactc aggaaattcc aagagtttta 317820 ggaacttgtg tcaggtacca gggacaaaga ccaaatatgt atttcttatt atgtcatacc 317880 ttgcccgcat acaccctcac acacaaacac acaattcaca catgtacaga atgaaaaggc 317940 aaagagtaac atctttatat ctgtgtaagt caattagttt aggatgattg caaaagttaa 318000 aacattccat agaacaggaa catagtgaaa gctcaacaaa tataataatt gagcctgctt 318060 tctcacctat aaattatgat agacactacc ttgaaatggt tgtaagaact atacatgtaa 318120 gattatttaa tacttgatgc ccagtggcgt ctcaggggat gatagcctct ctttctcttt 318180 ctctttctct ttctctccct tcccttccct tcccttccct tcccttccct tcccttccct 318240 tcccttcccc tcccctcccc tcccctcccc tcccctcccc tcccctcccc tcccctcccc 318300 tcccctcccc tcccctcccc ttcctttcct ttcctttcct tctttcagca attccaaact 318360 tgcagactgt taggaacttt ggataatttc tccatctcga aagtaagctt gtgatattcc 318420 ataaatcact tagcttagac ttaattgtgc tgtaaacaaa caaacaaaca tatctgaatg 318480 gcttccaaca gcaaatgttt acctcttgcc ctctgttcat gtcttctgta agtttagctg 318540 aggtttggta tactctgtat ccaagactcc tgtgaagaaa agtccccatt tgggacatac 318600 tcgtctcata aaacagggga aaaacagata atggcaccat gcagctgttt ttgacatatt 318660 tgcttagagg tgggtagcat catttctgct tcactgtatt ggccaaagca aatcagatgg 318720 ccccgcctgc tgccaaaagg ctggaagaag taagattgtc acacaagagg agatagccaa 318780 catttggaaa tagtaccaca aaccatcata tttctaaaca tattttaatt gctctcatac 318840 acatgaatga ttgcaaactc gggttcctca tttgctcatt tgtttatgca tcactcacca 318900 gacagtcatt gaagaatcgc tgtgttctag atactgtgtt ttctgatgta ggtgatacag 318960 agagaaagaa aacgcaatct acgtgtagct agaaattttt tgtcattatt tcttttttca 319020 gctcaaatga attctgatag aaaatttttg gtagagagca aaaggaaaaa atactgtatt 319080 ggggaatgtg tgtgtgaatg tgtgtgtatg tgcatgaatg tgtgtgtgaa tgtgcgtgtg 319140 aatgtgtgcg aatgtgtgtg tgcatgaatg tgtgtgcgtg tgtgtatgcg tgaatgtgtg 319200 tgcgcatgtg tgtgaatgtg tgcgtgtgtg atgaatgtgt gtgactgtgt gtgactgtgt 319260 gtgaatatgt gtgtgaatgt gtgtgactgt gtgtgaatgt gtgaatgtgt gtgaactgtg 319320 tgtgaatatg tgtgtgtgaa tgtgtgtgaa tgcgtgtgtg agtgtgtgag tgtgtatgtg 319380 tttgcgtgaa tgtgtgtgta aatgtgtgtg tgcatgtgtg tgtgaccgtg tgtgaatgtg 319440 tgtgtgaata tgtgtgtgaa tgtgtgaatg tgtgtgtatg agtgtgtgtg agtgtgtgtg 319500 aatgtgtgtg tgtgagtgtg tgtgcttgga agatgagcat gatgtcaaac aaacatacac 319560 ttccaaaagt agtgggcatt cctgcttagc cttttgaaag cgatatgggg aagagagaaa 319620 agaacatgag ccatgcctca ggtactccat gtccagggaa tgcaaacttc ataaaggcag 319680 aggtcacatc tgcttctgct cacttctgtg tctaaactca ataactgctc tttggaaaag 319740 aggaaaccaa gtgacccaac acatggatac acagagtcag gggacagcag ttcccacaga 319800 agaccaccgc agcaaagctg ctcccaagta gagatagtga tgcctgctca cggtcacagg 319860 ctgtcagagg ttatgtgccc agcaagaaca aaaggaccat tggaaactgg gtagcagttg 319920 gggccgttct gagaaggcaa cagttcctct cttctgtaag gacaactaga gggccagagg 319980 gaacttcgtg ttgagatggg gctgtacggc acccagggtt tagtgatgga gggctaggag 320040 gctttgatcc aggagcagaa gaggcaggac atgctcatgg agctcatgag gaacaaatca 320100 catttgagag agcagtcaat ggtaattgca agtctgaggc cgagcatggt ggcttacgcc 320160 tgtaatccca gcattctggg aggctgaggc gggtggatca cccggggtca ggagttggag 320220 acaagcctgg ccaacgtggt gaaaccctgt ctctactaaa aatacaaaaa ttagccaggc 320280 gtgatggcgt gtgcctgtaa tcccagctac tccagaggct gagacaggag aattgcttga 320340 actcgggagg tgaaggttgc agtgagccga gatcactcca atgcactcca gtctgggcaa 320400 caagagtgaa actccatctc aaaaaaaaaa aaaaaaaaaa aaaagaaaaa agaaaaagaa 320460 agtctgagca ggttttctgg gacttagcag tgttcctatg caggctatac atttacattt 320520 aatgttaatt cttttgtgga tgtgttttcc ccattaattt atcttcttgg tatgactttc 320580 cccagagtgc atgtaagaaa taatgtgctg ggcaaagcaa tggcttggta gaagaaaccc 320640 agcacccctg catggactgc atacttcaaa cataacttca aacctcctac taggtttgaa 320700 gatccttaaa gaaagggata tctgagtatc ctgcatatat taggtgactg gtgaatgctt 320760 ggggaatgga tatgtgagta agtgacggtg tcattgtcat gagaaagaga aatattcctt 320820 gcattttctt attctatcaa tcaagtctat aagatgtcta tttactctta tactttagca 320880 cagtgctggt gagatgaata aacaggcatt aaagagcctt ctagagcata ttaaaacaaa 320940 ttacttgctt tgcaagctca atttaatttt atttccttaa aaatccaaca aaagtgcatt 321000 gaatcacctc taagcattaa gtaatgtgca aggttctagg gtttcactga tgatgaatat 321060 gtgattccta ctttcaaaga ccactttcaa ctgaagaaac aggttatcta attttaaaaa 321120 ggtagcataa tttgtactct aacaattgta tttgtataga gccaagacag cattgttgtt 321180 ctctctgcaa agttctcagg gacgtgttgt tgacccagtt gttagggtgg ttaaagctgt 321240 gaatgaaccc tattttaagg cgttagcaag aattcagtct ctttcatcat gagaagcaat 321300 gatcaaggaa cagatacatt tataaagttg aagaaaatac cgaaaaatgt attgaatcta 321360 tgttttccca ggaagattgt cttttcttta atttatccat aaaaaatatc tgattttaca 321420 attttactct gtgcctttaa gagatagaaa ggaatgaatt ctattacatt gcattgtttg 321480 gtgccaagcc ataaatttac atagttgcaa cataaacagt ttcaaattat aactctacaa 321540 tatccaaacg aaacactatc aattcttttg ttattgactt gttttatagt tgtaatgcag 321600 actccatata tttgttattc agttttttat tatattattt ctcaggcaat tacattttta 321660 ctgcaaattt gggggattta cttgatataa tcattgagta caagcatagt gctaagtatt 321720 taaatgagaa tgttatcaaa tgaacttaat ttttcttgtc ctgttgcaac cagattattt 321780 ttactatgta agatttatta aaacatattt tcaattatgc tgggaaattt aaatgaggca 321840 agcattccac acataatatt gcctcccaat aaggttgaca tttacaagat ggtgagtaac 321900 attttgtgtg cttatttctt aactactttt gattttgtca atacaagata aattagccaa 321960 aatcaggcaa ctatgtttag gcatttgtat taatcaggtg ctccatcttg tctgcaatat 322020 tgataggaat gtttagcaac tgtgccaagt agactgagtg gtaaaaatga atacagattt 322080 tgctataaat tgcaaataag tacaaaatta atctgattga cttaatcagg aatacagaaa 322140 aacattagca tttcaagtac ttctattttg atttgcagga ttcattggcc atgtaaaaca 322200 gcaattctat aaatcctcag aagaaatagc agaactgctt ttacaaatta ataatgttta 322260 tgttgtgtaa agtcatttta gacagtgcca gtttggtgtt attgtttagg aaaaaactga 322320 gccttgtaat gaaaaataat tgttcctctg tcataggagg ggtttaagac atattccttg 322380 attgaatgtt tgatataggc tcaagcactg gtgggaagtt aaagcgttct tggtatgacc 322440 tcttctgctt gtccctgttg accaagttct ttaacttgga cacaactcac caccccacaa 322500 accctctcct ggtattttgt gttggggttc ctacagtaaa tatcagttac tggagaaaag 322560 gacttttcaa agaagcatgc ctagtactaa cactcaacat tcacattcca tattttcttt 322620 taaccaactg tctaaataag tatatattgc acgaatattc agttttaatc tatcgtaatg 322680 ttctcaatta ttctttgaat tagctagttg ctattattga gctgatttag aattaatcag 322740 tttttctgaa cacatttgta agaagaaaca atttaatctt ttccccattt ttacacctca 322800 aaattatctt aagaattcat ttacttttga gacagaacca tttctagttt cagtaccact 322860 tttgaaagag tacacatata ggtagatcaa ctttgaaaaa ataacacaat aggtagtgta 322920 tataggatat attgtataga aataggagga aactttcctg taataggaaa ggaaacttcc 322980 gtcttctgtt tgttaagaaa tatttgagag atctcaccat cctgccttct tgctttggcc 323040 aaattgaata aacctttctc tatctctcag cacctatgtg tcatgtttgg cattagctac 323100 acatcccata caggagcctg aatttgggct tctacaacat gagggtggcc tctagaaaca 323160 accttaagag ccccttgcag taacccaaac aggagataat ggtaaaagaa cttttccctt 323220 tctaggatgc tttgtagaat aaaacattta gatgtgttgg tgacaggctg ggaggctggg 323280 agaaagggta agcaagacca cttcaaagga tttattgcct ctgaaaacca ggaatgttaa 323340 agctgttatc tactgtgaga gggactaggt tgtaatgagg gtaggatcag gagttgggtt 323400 ttggacttgc aacatttgga atgactactg ccatcccagt ggcattcagt gagctccacc 323460 catgaacacc aagcaaaagg aggcaaacag gagacagtgt cagaaacaga ggatgcaccg 323520 gcagaggtga aagcaaacag cctgaaactg aaacataact ggaagagtca agctgccgct 323580 tctcatgatt aattttagtt ctgtgtgggc taaggctaat tagtaatgta agaattacat 323640 gagcaggact gaaaagtatt tccccagccg tggcatctgg ctccttaaag ggttgtattg 323700 gcagctctat ggtgctctcc aaatctggca tatggctgaa attgggtttt ggcaggtgtg 323760 acttgtgccc ttgtaccttt tcattaatgc atcctgtgtt tattggaata aaaatggtat 323820 tgaacataat ccatttctaa gggaaagcaa cctcaaaatg atatatgttt gcgaacataa 323880 ataacattta ataattaaat gtcatttcta actattaaaa gtgcttgcat gtggattatt 323940 aaccagttga caatcattca tgggaaggtc actatgcata tctcgttatt gtaaaggagt 324000 gataaaaaaa aaggttgatc attattgggt attggatctg cacactgatt agataggagg 324060 ggtcccaagg gagaggcgaa gttggccagc agtggggtga gcacggggag tgttggggca 324120 gtggctgtgt accagtcata tagtcagatt atgacacttg agcagccctt tgtttctagt 324180 gttttccagc taatacttac actggtttaa gcaaggtatc ttacaggatt ctctcaacaa 324240 tctggtggtt tgtgtttctt tggcaattga aatagatgcc cagaaaagtt gtgattttcc 324300 taagaacatc cagctggctg tgagcagtac tgaactcaca tccagatgaa ctggactaga 324360 agagcaggct acatgttttt gaaatttcta aggattgtta atattcaaat cttctttctc 324420 aacctggtca tataatctct gatatcacct ccttaaactc atctagtaat atttcccatc 324480 ttcagagcct aaatgtcaaa tgtcatcagt tttatgcttt tatcttacaa taatataaaa 324540 taaaatgact ttactcaaac cacattgcaa aagcattttt ccagcatatt aaccttttta 324600 taattgttga tatggaagag ttttaattcc gtcataggtt ttatgcattt taaatattga 324660 gtcttggact gtgctgatat ttttggtaaa taaacagaaa gatgtgcaac tgtgctgaca 324720 ttacagtctg gagaagtgag aaattaactc tgtaggaagt caacatgatg tcagatcaat 324780 gtgaccacta aatagatgag agttgccagg gcaacttttc acatgctcta agcaatgtga 324840 tggtttgttt tcctattgat gcatatgcta ccctattttg gctaacatcc aattcaatta 324900 cgtaagtatt tattgcaccc tttctacata tccagcatat tttataattt tctgacatca 324960 ttcatatatc tattcaaaaa cgaaggctta cacataatga actggcttag actttatcta 325020 ctttatctac caggaaattg attctttttg taaaaatgac gagttccatc ggccaggatc 325080 tataccaaat tccgaagcca aggatatgtt agaaaatatt ttgacacacc agcctttact 325140 tgatctgtag tataaagcaa gagtttctaa cttgcctact atcttttttt ctgcctctga 325200 gataacatat acaggttgct gttatggccc ctttaaccat gagtatacca agggcaaaga 325260 ggtagaagtg agtacaggca ctttagctaa acatttagtt gagttgagtt taacttttgg 325320 tttagttgaa gtgcctgcac ttaatcaact aaaagttggg ctgctttttg ttattactgt 325380 gcatggccaa tccaactcag tgtatttaac tcatagactc ataaatcagt gcattaactc 325440 atagacaact gtgtatcttg tttgattgat tgattgattg attgatttgt ttattttgag 325500 atggagtctc actctgtcgc ccaggcttgt gcgttcttgg ctcactgcaa cctccacctc 325560 ccgagttcaa gtgattctcc ttccttagcc tcccaaatag ctggtactac aagtgtgcac 325620 caccatgcct ggctagtttt tttctttttg tatttttaat aaagatgggg tttcaccatg 325680 ttggtcaggc tggtctcaaa ctccagacct caaatgatcc acccgcctca gcctcccaaa 325740 gtgctgggat tacaggcatc agccaccgca cccggcagta tcttgttttt tatttttttt 325800 ctttaacttt ctaagtatga aggaagctac gattattctt tccaaatctg tcaggtcatt 325860 ccattcctct gcaccaaacc ctgcaatgat ccccctctcc gtgcaggaaa aaaaacaccc 325920 acagtccctt caatacatcc aatatgctgt gtgtgctgcc ctatggtctc acctcctccc 325980 cactgctccc tttcttcctg tgctcattta ctgcccctca ggcctttcac catttaaaca 326040 gctgtgccca ctagcctacc tgaccacttt gtaaggatgg ctcccaccac ctgagtcact 326100 ctttcatcta atatccatgc agctccacag ctcttctttc agttttacac aaatactgta 326160 ttttcattgt ggttgccctg actgctgggt tcaatacttc agatcccaca cctagcatgt 326220 ccagctcccc acatcctgtt tcatcatatt agatcactta acatcttaaa atacactaca 326280 tattttgctc acttattgtg tttactttat ttttcctccc actagaatat aagaccaaaa 326340 ataaagatga ttgtctgttt tgcttttttg tctccctgat gtatctcaag tatctagaag 326400 aatggcacag agtaggtgct catttttgtt gttaaatcaa agagtgaagg aatgaaagtt 326460 aatcctgaat cttgtattct gtcctatcat tattttaaat atcttaagga tgctcttaca 326520 aataagtact aaaaaatagc aggagaaatc tatgccatcc aagaaaatct ctgacaagct 326580 gtcacatgtt tggacacctt tagtcagttg aagaagaagg ggagttgtgg tcttctgggt 326640 aaagaagttg ccctgggagg tgactggaga ccatcttaca caaaataact tgccttgatg 326700 cgagagaagc cggagcaaag gatagtcctt ttcagatcag gtcaaaagac cacctacaac 326760 gaaatctcca gccatagaga ggggcattat gtatggcaga tgccagacgc ccactattta 326820 atccaaagaa gaccagaact ggaccaagtg cactagaata tctgcagatg ggacatggag 326880 acctgtactt cctagcaacc caggagaccc tggcttgacc taaactttac ctggataatt 326940 ctattttctt ttttgttttg agatgaagtt ttgctcatgt tgcccaggat ggagtgcaat 327000 ggagcgatct tggctcactg caacctccac ctcccgggtt caagcaattc tcctgtctca 327060 gcctcctgag tagccgggat tataggcatg ctccaccatg cccagctact ttttgtattt 327120 ttaatagaga cggggtttca ccatgttggc caggctggtc tcgaattcct gaccttatga 327180 tccgcccacc tccgtctccc aaagtgctga gattacgggt gtgagccact gctcccagcc 327240 tgccctgaga attcttacca atggtgaggc accaagcatc ggattggagg gagaagggtt 327300 ggtataaaaa cagaagaaaa aggaagaaga tgggagggac ataaatcaca aatgggctga 327360 gaagctctat tattattgtt attatatatt atttattatt attagcttca ttttgcaaat 327420 aaaataaacc tcaccaccaa gctctagcag caaaacattt gcggagcacc actgtgtgct 327480 tggccccagg cacacctgcc atctcatctc tatcgacaca gattgttcat tttgcagatg 327540 agaaaagttg ataataggag agataaagca attttcataa gattgttctc tcattaagca 327600 aatatttatc aaacaccttc tatgttgtct gtgggtgggg catcctgaga ggaataaggg 327660 agatgaggtt tctgctctta cagagttcac attcagctgg gagaggcaga ccacaaaaag 327720 cgactaatca atgatgaaga agctttgagg tcacggagaa gaaagtgcgt ggagagctgg 327780 gatgcagtgt ctggagcctg gctctggcct ttcctctcct ctgctaggct gcagttctgg 327840 gcaagagcag acttcactga aacccacgct ggctgtgtta gccaatgtgt tgacagcacc 327900 ctgtgtaaag aagtcaccca acactgcatc agtgtgtaaa gtggaaacct aacaatctca 327960 caatgttcac gaaacgctaa ggacatcaca aggaatgatg tagtaaagtt tttccactga 328020 tgtcatcttt ggaagtagat tttgctcaat tcttattgga acatgtgcac agctgaactt 328080 caagatcctt gggttctcag ctcaaatcta tataaatgac ttaaccaatt gcttaacttt 328140 ctggaattca gatgctttaa ctgtaaaatg gtttggagct ctgaatggag tatttccaaa 328200 ttatatctaa ctgtgaaaat tcaatgacat agaagattta ggatggagag gaaaaaaaat 328260 aacctacata acgtacaaat gaataaaaat tataacaata ataatataaa tttattaagg 328320 tgagatttaa aagaaaaaag attgctattt ttttattgct agttaaagct attcttggaa 328380 gatttccagg tactttttaa gtgaaacgtt gtgtgcatga gatgtcctta tatctttttc 328440 aagtatatag atgggctcta ttcaaaaagg gcctctcttc tcgtcttatg cccacctgcc 328500 atctgagcaa ctatatctat tttttgctgg gctacgtgga atgattgttc tttttatgtt 328560 cttgcctaag aacacacaca accacagcac tcctgacact tagaaggaga tgaattatat 328620 ttaaccgaaa ggacacttgc ttgactagga ctgctaaatg tgttagctgc agggaaggcc 328680 agctgccttc ttggccattt ggacatgccc aatcttctct tactgatgca cagatgtctg 328740 aggccttgtg ggtgaatccc agtgtgcttg cagccaggag aaggtattgt gagcggtgct 328800 gagcatgtga ggtgacatat ggttctcctt ctccatttga caactttatc agcttctttc 328860 catagttcaa gtttgcagct ctgcagaacc aaaggctgct attcaaaata gcctcatcac 328920 ctcttcctta ctccctcaac ctccagccct tgtccaattg cctggattgg gaaagttctg 328980 cagtggtttg agcaatcact taataagacg gctgtcggtg gtaaaactgg aattggttgt 329040 tgctattgtt gcggctttgg tgagtatcac aagtaagcac tggaaaatta gaagcaccca 329100 gaggttttag ataacatata tgtaatggac aatcatgtca gggacccatt gattcctata 329160 tagaaacacg ctgtgccgta agtctcttta cttgtatgta ttataaatat ttagaaagga 329220 aaagtgtgtg tgggggtgtg tgtgttttat actcaaaatg aactttttga tcactacaaa 329280 attcatttgg tatggtaaaa tttagaaata atctggaagt taaaatttga agaaatatca 329340 ataatggccc tttaatatat aaacatatta ttactattat aaagattata tagcaatatt 329400 aaaataataa tcatctaata ttcaatgaca atggaaaata taaaatatct atactcatga 329460 tatctctaac agtgtgtgta tatgaacaat gtgtggaaag aaacacattg aattgttgat 329520 atgtgatagt ggtaggactc ttgttcttat tttaaagctt aatttcatta gaatagcatc 329580 tgcaaggcat atatcaaaat atatgtttat aaggttttaa taaataagaa tatgaaataa 329640 ggtgcattga tctcttatta tgtgtcaagt ctttgggccg ttcatgctca cagccatgtt 329700 gtgaggcaga cagtatgccc attttacaga tgaacagacc aaggccgatt aaccaaggtt 329760 aaattaattg tccaactgta gctacaaagt tacgattaga aataagttct ggtgttctgt 329820 tgcatactag gtttagtgtg gttaacagta aggtattgta tattacagaa tagctagaag 329880 agaggctttt gaatgttctt accacaaaga aatgataaag acatgaggtg atgaatgagc 329940 taactaccct gatatagttt ggacatttgt cctctccaaa tcttatgctg aaatgtcatt 330000 cccaatgttg taagtgagac ttggtggaag gtagtgtatt atgagggtgg atccctcatg 330060 aatgacttgg caccttccgc ttggtgatga atgagttctt aatcacatga aatagttcac 330120 acaagatctg gttgtttaaa agtctaggac ctcctgtctc tctctctctc tcttgctccc 330180 tttcacacca tgtgatactc cagcttcccc ttccccttct gccactattg aaagctttcc 330240 gaggctccca ccagaagcca agcagatgtt gttcacagcc tatagaacca tgagtcaaat 330300 aaacttcttt tctttaaatt acccagcttc aggtatttct ttataccaat gcaaaaatgg 330360 cctagtacat accctgattt gatcagcata caacacatat acaaattaat gtaccaaatc 330420 atactccaca aatatataaa attacaatgt gtcaacttaa aaagaattac atatttgatt 330480 tacaaatttt ttattccttt taattctatc tcagtatttt ttacaatctt tgattacttt 330540 ctcatttttc taattccatc ttttatttgt tttaaataaa tattttaacc aaaactgtta 330600 aaagaagagc aacgtgcacc aaattaagtt cagtgctctt tcaacaacat gaaatttcta 330660 ttatgcaaag tactgaaatg aggtacacaa aaaactcttg ttatcttaga gcgagtctat 330720 tgtcaatgtg tctggagaga cagagaacaa aaatcctagg tctcaaaata gatgattctt 330780 tttttggaat agtttactcc taaacaactg atatacatgt ttttctattg tatttcaaat 330840 aggtgaagtt attttcacta atcctgtcgg tgctcacagc taagtcctac aatgacagat 330900 catctaccag caatctagag aaaatcagtt ttgtgtatag agaaataagt tcccctggcc 330960 caccatggcc agcatatgac aaggaaatga cagaggggac tgactatctg ggccagggga 331020 acaaagggag gtttgcagag attctgaggg tacacgcaag agagtaggga gcatttctgc 331080 agcgagaggt acttggccat ggctacagca gacaaaggat ggtcaggaat actttagcca 331140 caacgttagc acagacatta gcagaatgct aaatcgtggg atccaccata accagaagaa 331200 tgctagatca gtcccacctc agcaaggact ggcaaggacc cccaaaacaa agaaaaaatt 331260 caaggactct gtcactccat accacaagtt cacaggagcc cttcatcctc caaacagtgt 331320 gatgccacac tgcggacata cagatgaggg cagaattgat gagactgaaa aagtgcctaa 331380 agggattatt tacaatattg gtttggacac agttttgaac caaattagac taagtaaatt 331440 tccattttta tcatcaaata aaggatcatg aaggaacacc acgtcagttt tagacaaaat 331500 gcgttctata tcggcataca cagatccccc tccatactgt gtatatgtgt ttactcatat 331560 atagatgtgt gtacatgcat agtcacatac cttattgaca ttacaactat catcacaatg 331620 gttttcacca tactatagca cagacaaata tttttatttt attttatttt agtttagttt 331680 agtttattta tttatttttt ttatttttca gacaagttct cactctgttg cccaggctgg 331740 agtgcagtag caccatctca gcttactgca gcctcaacat tccgggttca agtgatcctc 331800 ccacctcatc cgcccaagtg gctgggacta tacgtgcata ccactacgcc cagataattt 331860 ttttattttt tggtagagac agcgtttcac catgttgccc aagctggtct tgaactcctg 331920 ggctcaagcg atccacctgc ctctgcctcc caaagtgctg ggattacaag tgtgggccac 331980 tcaccaggcc aaatcttttg attacaaatc tatttgctca attcctagtt ctgtattcaa 332040 cactgatatt gttgttgttt tagatcacac acaattcaca ttgagccagt aatgtctttg 332100 aagcattact gaaataaaaa tttcagcata ttctcaataa ttttgcagct cctccaaatt 332160 taatcactat atagaatctt tatttacagt tttaaaattg cactagccat ctcttccttc 332220 accttttttt aaactgtaca aaactgagaa ggctgaaatt atatttttct cataatttta 332280 caaacatacc tactttttct acctaaaatt atccagaaag tgctttcttc tctatgtgtt 332340 gtgtggaaag gcttctatat gcctattttt gaagaaaata gttcactttt actccattat 332400 atgaaatttt ttcattattt aaatcctgtg attagttttt tcactgaata gtcacttcca 332460 tagcagtttg gttaaaaatt ctacagtaaa agtagtaagt gttggccact taccacttgt 332520 aaagtgtatg ggcatagctg tatgtgtgtg tttatacatt tatatacaga tgtgtgtata 332580 ttaaatatgt aatgtaatat aatacaaatg gtctctgact aatgaaggtt aaacttatga 332640 ttttttcacg ttacaatggt gtgagattgg tgcacattta gtagaagcca tactttgagt 332700 acccatacaa catttctatt tttcagtgca gtattcaact aattacatag ctcttcaata 332760 ttttatttgt gtattttatg cacatattta ttttaataca aacgtacagc tttggtcaaa 332820 tgtttaatat tcactgtaat tttatgggtg acattagcaa gatctatttg tctaaaaact 332880 ctttcttaca aaaaaaccca ctttaaactt ctcaaatgcc cctccatccc atttttttaa 332940 gtttctaata aacataaaac atatttttaa aagaagaaga aaggctccag aagatcagaa 333000 caatacaact ggttttacca aattcaggca tttagaaatt gagaaaagag gcaattttta 333060 aacttatgac atgacaacag gcataaaaca gcctgctatg gacaaagcag caagtgtagt 333120 cagcctgcta aaattcagcc tctgtgagca cagcacttaa ttttacccct tattttttag 333180 tagaaatagg atctcagaaa tcaccggact tctgtattgg tctcgttgga agctgcagac 333240 cggaactgtt tctatttggc catcttggcc ccccgccgcc aattctactg taaagacaca 333300 tgcacacgta tgtttatagc aaagacttgg aaccaattca aatgtccatc aatgacagac 333360 tggataaaga aaatggggca catatacacc acggaatact atacagccgt aaaaaagaat 333420 gagttcatgt cttttgcagg gacatggatg aagctggagg ccatcactct cagcaaacaa 333480 aggaacagaa aaccaaacac tgcatgttct cactcataag tgggatttga acaatgagaa 333540 cacatggaca cagggagggg aacaacacac accgggtcct gttggggcgt ggaggaaaag 333600 gggagggaga ggattaggag aaatatctaa tgcatgtggg gcttaaaacc tagatgacag 333660 gttgataggt gcagcaaacc accatggcat atgtatatct atgtaacaaa cctgcacatt 333720 ctgcacatgt atcccagaac ttagagtaaa gtaaaaaaaa aaaaaataag aatcgcacta 333780 tgtttcctag gctggtcttg aactcctagc cttaagtgat cctcctgcct cagcctccca 333840 aagtgctgag attacaggct tgacccacca tgaccagccc aatatggctt ttaagaagaa 333900 gctgagccag ccccacctgt ttcgtttggt tctggtgctg gcctgtgttt tgacaacatg 333960 cttgtaagag ttttaggttc tgtcagcatc agcagacaca gcccatcctt ctctccaaat 334020 gactgttccc ttaggcactt gagtcacttt tcagtaaaca tctgcatcat acttcaaatc 334080 ctgttactaa catttgtgtc tccaaaattt attctccaaa ccccaaaccc cgcacacttt 334140 aatgcaggcc tgaagtagat ggaaaagggg aaataaatga tgtcaccata gcttatcaca 334200 tgacctaaat taacttttca tgattgacca gcattaatat tcacagattt aacaatgctt 334260 tttaagaaaa aacaacagtc cagaagtgat tctttctgtg tggtagatat aggtctgttt 334320 atttttaaat gtgtttttct ttgtactttt tcgttctgaa aactcttgca ttttcattta 334380 atatcactca ttataaagtt tatctctgaa gtaggatgta ttttctgatc atattttcat 334440 ttcttagaaa tatattgtat tttaatacct caattttatc agtattttta tatatacttg 334500 tttgcttggg ggaagatatg agtgagagaa gctttgcact tctttctcta tgggtaaaaa 334560 aataaaaagt taattttagc attagaattt attttagctt actatattca ggggaatgca 334620 aatagcaaaa tttctattct tctcaacact ctttccaaga tgaaatgtgc tcagattgtt 334680 caaacctaac ttaatagcta ttagaatctg tcttgtcgaa agtctcagat tctttatttt 334740 actctttgta gcagcaggac tctttggtcc aactgcccga aaaactattg tcaagaaaat 334800 gcccagtgac ctccaaactc ctgacctttc aattacctca gtggatggac cgagagaaag 334860 gtgactttta ataaaacaca aataatatca ctaaaccatc aaaaattgaa tcccaagacg 334920 gtttctcact aaattttatt ttccctgcct ccctcaaagg aactgtgtat tgaagttctc 334980 catctgctga tgatctctta ggcttatctc ggtgtagtac atccatttag caatgcagat 335040 aatcagcatt tgcagaatgg cactcagttt tgcagctgaa aagattagag tatacaatcc 335100 accattcatt ctcaagggaa ggagtcatcg cattgaagca gtctaattat ggccatcagt 335160 ccaaatggca tggtggccaa ggatcaaccc caccagcata ggaagttcca ggctccaaga 335220 aagcccagag gttttggaat tagtgagcta agtgagtttg cctcattccc acacatcttg 335280 ctcctcactt cctttactgt gccctgtggt tggtgacatg actgcatatc tgccacttct 335340 caccactttg tatattcacc ctgccttgtc ttgatttctc atcttgataa ttctcccatc 335400 ttttgctcaa gacactttta aacaactctc agagtaacat ccttctttgg ccctagtgag 335460 catttgaaat atgttctata ttctaaagat ccagaacatg tgggcatttt cacgatccag 335520 cctgtcacca tgtgttgttt agccacacgt gttcaaagca gatttcgagt tgagttattt 335580 ctagctgggc acaaacaggg ttccattttc ataggcctca ctcttcccta ctgcattaca 335640 tggtttcttc ttcacttcta ctacactact ccttctttaa attacagaag cttaaacata 335700 aacaaaagta gaacaaagtg gcataatgaa acaccacaaa tccattactt tgcttcaaaa 335760 tttcttagta caaagctatt attttttata cctacatgcc tgtgctgtaa aatagatgga 335820 ctactttgag ccaaatcaaa gacatcttat aacttcattg gtaaatagct tgtatttata 335880 agtaggtaag agacgttcac tttaaaaagc acaaatcaaa tatcaattaa acattcaaat 335940 ctcaagaatt ctcacaatcc ccaccccacc caccctcctc tatcttctcc atccccatta 336000 cactatcact cttcatttga ctggttcaaa tcagaagtca aatgaagttg acacgttgtg 336060 tttggttgat atgtcaacaa agtcacttat aatttatcat ttcttatctt gtaatttctt 336120 tttgaaaatg ttgagtttat cacatttgcc cttttcccag caaaaggcat cccagtgtct 336180 cctcactatg gagtggaagg agcaagaggt ttataatagc atcttgttat attgaagtca 336240 caagctacca gcatcttctt atattgaagt cacaggcagg atttaaattc atcttatatg 336300 taagtatggt atcccagtgt gtcagtgaag agacagatgt tactgagatc accttgccca 336360 gggacgcatc tcctaatatc tgcaaggatg tcctgtatac caaaagtata gcttcattcc 336420 ttctaatccc aaagactctc aaataaagca aatctgcggg aggacaaaga tgatggtaag 336480 cacagaggag aatgggtatc aatcacttac atcattagga aggagtgaaa tcttacaatg 336540 atctttccct ctgctttctt cctttcaggt gatctaactt cctgtgccag catcatcatt 336600 ttacaataag atttgacttt ggttaaagtt tgaaattctc ctctgaggaa acacatttca 336660 ggatgttatc tttcatgcat accttatcat gaagaaagga tccaactatt cataatctag 336720 atttccactg atttctttaa ccacagtttg ataacaacca ccagtgaggt agtcaggtcc 336780 aggtcttatg gaactttatt ctgttcattg ggaatgtggg ttttattgat gagggagtga 336840 taaactattg gagaattctc aattgtggcg tcatgtcttc tgagttatac ttttacagga 336900 atgattctgg ttgctctgaa ggaacagata gatgtgggga gacaagaata aaagcaagga 336960 ggcttgtaac tggctgtttt catactagag gtgagtgaga gagtttgaga gtttgatctg 337020 ggctttagag gccatagtct tactttatca cttttacaag gaaagaaaga aaggcccatt 337080 gtagtaaagt ggccccttta agaggccata gtaaaaggat ctcagtcctc aaatatataa 337140 aatagtatat attttttaaa aattgtaaaa acctttgcca ttcattttct gacttaaaat 337200 gcctgatgag gttgtcttag ttctcagatt tcaaatcttc tgatctatgc atggcacata 337260 agttcctcac tgaacaattg atgattaatt ataaatgcca ataatggtta ttgtttgaga 337320 ggagatgact gtggatatgg agaagtaaac agaacactct cctttctctt tgacttcatt 337380 taaccaattt tttctttcaa atcattttct agtaagaaac cacctacaaa tgcccagagg 337440 attgctgcct tatttaaagt attataaaac ttattgcata tgcataacgt gactgtgacg 337500 tggaaacttc tcagccttgc ccagtccttt tgaaatgtta agctcactgt aaaaatgata 337560 aaatattgtt attttctctt aagaaataat aaaattaaaa cccaagaagg aaaagactct 337620 gctaataaat aacagtgtca aatttaaaga agatatttgc ataaatatta ggtttaacca 337680 aatgaaattg ccaatattca aaagttttta accttcaaag catcggtttc atatggttcc 337740 gtctattaca aactcttgct ccttccaatc cactgtggca accttcagaa agatggggga 337800 tattaaatgt ccttttgttc tcacagagta tcctttatgt tgtgaacatg gacttagtta 337860 tcactgccac tctgtgggct tttatgatct attataacct ttactatagt gcaaatatct 337920 gtatatataa acacatatat atatagccta ttagaccctg aatatcttaa aggcagagaa 337980 agtctcttat tttcctttta taactagcaa ctggcatagt gacagacaag aatggatgct 338040 ccatatgtct ttgtttagaa tgatataaat gcaggggttg atgaatcata ttcttttaat 338100 aatcttataa gaagcagtaa tgagaagcca ttttgacaac aggcttttaa atcagacacc 338160 ctgggtttag atgtgaatcc gatatttact tcctatggaa gttgggacaa gttgctcaaa 338220 cttgaagtgc ctcagcttcc tcatatatgt aacagacaat acttacctca cagagatgta 338280 gtgataattc aataagttat tgcttagaat agtgagtggc atgtaataat tgccatatac 338340 atgttatatg tgtttgattg ttatttttaa taattgtttg ttgaattgtg attcctgtgt 338400 gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtcttgtgga ggtagtgatg gcagtgggag 338460 gctgttctca ctagtgttgc tttcagaatt cgttagcact aatttgccag ccaattacct 338520 gggaagtatg gcatctggtt gaataaagga gtcataattt ttataacttt tgtttttgtg 338580 accctttgca attttttgaa catccacagt gagtctcagc aaataaagca tctggaaatg 338640 aatattagtt gcaaactaat tgaagcaata acactaaaaa agattaaaaa aggataattg 338700 tcatgtttga gatcccacac aatagtgcca atatcctgtg ctgaatcttt tctgaggcct 338760 gaaaacaagg taaggggtca ttgcaggcat catgtgattc tttttcacag gaacttcagg 338820 actgaatcct gcagtagaag caagaacagg ctattgggag actctggtcc tcaactgcac 338880 aaagaagggc ccatatcctc aactctgcca cagacctctt tgattccagt tggaagcctg 338940 gagatttcac tgctgctgag gagggttcca gggactggga aacctgagct gtgagctgag 339000 cttgggtgat ctgtttccat ctgtggtctg gtgctgatgg tttccaaggc aggaatcaag 339060 tcagtccttg aagagctaca acagagcaaa agtgcaggta tgagagcata gatggacaaa 339120 aaaaagcaag taatcataat cagagaagag ctggagcagc taggaaattt agaagaagag 339180 aacaggttac aatagatgcc gtgaacacag cgatggttct aagactatgc ccatcttgtt 339240 tacttctgtg gcttcagtgc ctgacaaata catagtcagc actcatcaaa tattaaataa 339300 atacatgcat gaattgtcaa aaggaggtga cactatccaa ccacttaaag tataaatttt 339360 tccagataga tacaatgcta cagatacatt atcaaatagg atggaggaac tagaagatta 339420 agagaagcat tagattgctc tactctggaa gtaatctcca gcaagataag gaatcaattc 339480 tctttgccca tttaattacc atatttcctg aagatttaga aatattttat ctggctccct 339540 ggtcctaata tttgaggaat ctatgatttg ataaatggaa caaatgcctt acagagatat 339600 gatatagcca gggtgtcttg ggcagaaata cgtaattggt aaagtcaaga tggtggaagg 339660 taagctctgt ttctgaagac aaatcacatc cctgtacttc agacttgatg ggtgtctatg 339720 agcaagaatg ttttctctat ctgagcccca gggtaaaaga caagacatgg agcactctaa 339780 tgtagccaat cgactcagaa tatctcattt taaatatatt ttttcatatt agatgtgcga 339840 gtgggaaagt aattatgagg tcacacatcc tttccttagg taaaccaaca tttttttaca 339900 tttaggaaga aactgaataa aactgtcttt tgtccaagtt aatatacctt gtgaacccca 339960 gctttttgtt aagaaaacaa agtgctgtga cttattttaa acaacagaag ggaaacatga 340020 cttctgattc ataacttccc ttaggcttga gggtctctga aaggagagct ggaaatgctg 340080 agagatgtga agatgctttg ggagggcaca gtttcccctt tgccttatgg gagattataa 340140 agtttcacag actatcacca ctttacttta gaattttcct caatacttcc ctctagaagt 340200 ttgcagggaa gatctcttct tggttattaa tatgtttcag aaatgacagg ctaaagttct 340260 acctacccag atggaagcaa actgattttt ggcttctctg tttgagtggc agccagtgta 340320 accctgggtt tctggttgaa attccaatgc agagattccc aagccatcag ctggaagaca 340380 caactttcag caacaactct gtttgtgccc atcaggaagt tggatgaaat aattttaaaa 340440 tatggatatc tgtacatcca gatattttca gacaagttca gaaagattat tttataaggg 340500 atgcaattag aaaaacaatt attacaaaaa ttgtactata tttaataaac ctcctcctat 340560 gtctcctaca atgtgtgtgt tattatcaga ttgatgggaa catcactgaa taatcagatc 340620 aagtgaattt gattggtgag aaaaaaatat gctcgcttat gaaattaaca attggtcatg 340680 acacagagta acaaagattt tatttattat ttattctatt ataatgttta aatatataat 340740 tttatgcaga ttatgcattt tgcataaatt ctgttatgca aaatataaat tctgttaagt 340800 tctatagagg gcagaagttt gatttaagac aaatatgaga aaatgttctt tcatgactga 340860 ataatatgat tctggtaaaa taagtgtctc tgagagaagc ctcagacttg tgtttttatg 340920 ggaagagcga aattcttctt gcttgagggc aaccttttgc agagaggaaa aataatagca 340980 agaaggaaag gtgaggacta ctttttgata gtggaaatca atctgtgatt catcacaaaa 341040 tacaagtcat ctggagctac aaatttatgg gtggtttaaa tagcaagaag cagaaagcat 341100 atacttgggg ataactggaa agaagatcag aggtgaccca agtttcagga attgaactaa 341160 agagatggtt ggaataaaac tttttcagtg gaaaggcaga agaagggaag tgatttttat 341220 tgtctacttt acaacacgct tagccaacat tatctcactt taatccacac cacagccgta 341280 gcctttcaca gtaatatcat ccacatatca cacagggata gatggggtta tgttagataa 341340 attgtccatg accacccagt gagtaagcaa cagagccaga actcaaacct aggttgtcat 341400 ccaatgtcag gcatttttca agtttggaaa aggggtctat acttctaaat atatagagca 341460 atattctgaa gagaaggtta aataatatgt tgaatggaga gaactttatc ctgtctgaac 341520 aacctctttc gatctattta gattacatgt gaaaataaaa atgttctgtt ttttctctat 341580 atggtaaaga ataaaagtac atatgtttat caaagtgtac aatattctaa atcaggagtt 341640 cttgaataaa ttaattacta catgctagaa ttcttagaaa tttagattac acactttgtt 341700 tttataaaca gatatttaaa taacatcggt ctttgcgtat ctatgcacac gcgatgtaga 341760 ggatattttc accaaatgta agtgggatgg aggcggcagt ttgttgactt ttcctccaat 341820 ctttattcta ttttaaagcc tttagggaat tgttccttca gaaacaacgt cagatactgt 341880 ctcaaagaag cttttctgga aagccctgat attaaaaaca aaatgagagc cacaaacaac 341940 aaaaagtcca ggatgtccag agaaaatggt ccatcttcag gcattcctga aagcagacca 342000 tcaccaactt tgtcatcatt attattattt gctcaggcat ttctaaggag ataacatcat 342060 atctcccagg aactgcctca aaggcccaat ccacacaagg aagccctatg caaaattttc 342120 aatgaaaatg cattgcctag agtaaagatg gagcattaag agaagatgga ggcagaagta 342180 aggatctatg agtaaatcaa tggccatgaa aactggaggc actaaaagaa gctggaacaa 342240 aacaggttga ggtcaagatc agaggtaggg aatgcactgg tgaaatatac aagctacgta 342300 gggttagatg gttcaaagga aggccttttc atgcagggtt gtacctaatt gtagacttaa 342360 aattgaggct tatggaatca cagtagtggt tgaccctaaa tgattatgtt attattctta 342420 tcccctcata tgaatttttt aaatgacttt ctgctaaaga cgcatttcta tttcaaaatt 342480 tagtatcatt atctaactct gactctcttc ctaattcttg tccttctaaa tcatttttga 342540 gagctaatta ggttgagtgc cattttcaac tgctactttg gaagataagg tacatgcctg 342600 catattgtgc gcttactgct gtgcacatct gtgctcaata tcaatctgca gggattctga 342660 aaattaacat ccctttaaag gcaaacagga ttacagggaa agctatgtat tattacttgg 342720 tgtttggttt tacggataca gcctggattt caattgaaaa tagtaagaaa attagaaaat 342780 attttctctt ttctaaaaat gctcccctcc tccacacaca catagaaaaa tataattaga 342840 aaaaatcata tcttaaaaag caaataagta ctttaaaaat atattcatag ctttgaaaga 342900 tgcactatgt caatataaaa ttaaatccat ttttattgtc aagaaaatgg gctaatagaa 342960 ttttctacca attttatgat aattggcata tggataaaac agaaaaaaac aaagtcttga 343020 ttagaattac tgtatctgga ggttttaagt taggggaaaa aaagtcaact tttttttttc 343080 ctctctctct aacagtttat cacaagcaca gtttcccccc actactttca attttatatt 343140 ctaggtttta gacctctgaa atctgagaag atctgtgcct aggggaaaga gactgccttg 343200 aagaaacatg tgtttgtgac tgagtcttat cagagtataa ataacacaac tgtttccaag 343260 aagaaaagat cagataacat atagtcaatt gtagcctgca gggttgaaag aattgacagg 343320 ttttattact tgctcaaatg aatctttaat actttttgtt ttgttttgtt ttgtttttga 343380 gacggagtct ctctatgtcg cccaggctgg agagcagtgg tgcaatcttg gctcactgca 343440 agctccacct cccaggtcac gccattctcc tgcctcagcc tcccgagtag ctgggactac 343500 aggcgcccac caccacgcct ggctaatttt ttgtatattt agaagagatg gggtttcaca 343560 gtgttaccca ggatggtctc gatctcctga cctcgtgatc cacctgcctt ggcctcccaa 343620 agtgctggga ttacaggagt gatccaccgc acccggccaa tactttgaag atagtaagaa 343680 aaggagcaag atcggtagtt aaaaacacca gagaatgttg ctagaatgag ctccacaagt 343740 gtatgttgaa ttctctggtg ttatagttgg gacgacagag tagacagagg gagtgattaa 343800 agaacagaaa cttaacacac cggagcaccc ttgtttgtcc cgtgctttac agtcttcatt 343860 taacttatca cacacatagc aagtacagta tagacagaaa ccaagacaat atgctataag 343920 attgagtaaa aaggaaagtg atttaaaaga ataaggaagc caaaaaggaa gcagtttgtg 343980 gtcgcctgag agatttgtga ccataaagca ggggctggtt aatattttct gcaaatatcc 344040 agatcgtaaa tatcttagat tgagcaacta ttcaattctg ctttgctggt aggaaagttg 344100 cctagataat atatcaacaa atgggttttg ttccaataac actttattta ggaaaactga 344160 aatttgaatt ttatattatt ttcatatatt acaaaatgtt tttcaagcac taaaacatat 344220 gaaatccatt ctgtactcct ggattacaca aaggcaggca ctgggctgga tttgtccagt 344280 gggctaccat ttgctgatcc ctgcattagg gcctgtgctt ataccttgac ttcaggtatc 344340 tgcaaggata aagaggagga accctataac accctcaagt tctctctgac cactgtgatt 344400 tttaaaacac actttctttg aatggctatc tttttccttt aagagataac ctccacattt 344460 agaaacatag acactagaag gtctggcaaa tgaaagagaa ttgtggatta tttttccatt 344520 gaatgattta aaaataaata aaacaacttt gattgacatc tggtagatta aaaaggcaag 344580 atttatttcc tacaaaataa agaaactgac acatatgtca gacacacgtg gcatttctga 344640 tgtggaaaga aggaaagaca tcaataagac caattaattt actttcttta gctttgtggc 344700 aagtcaccta actcgtcaat ctgtgtgcag gcaaatatgt attacattgt tctgtgctag 344760 gatggtatta aacattgcca ctttttaatt tactctttat tatactgaca ggtaaacaaa 344820 gcaacacgaa ggctaaataa aagtcatttc cccaaggtaa gtttacaatg ttggttcatt 344880 tacagtttag tggtcttgaa agtgaagagt ttattttgta ttgttcaact agcttgcttt 344940 gctgtggata cacttgctca atattagtta taaatgtaat ggacatgtct atataagaat 345000 gagtataggt cctataatgt ttatttaacc aggctgaata atgagaaaca tccttgtcat 345060 ctatcacacc cttcaaataa aaagatgagc aaccctgagg gtgcgttgct ttttcttttt 345120 ttttttttct ttgagatgga gtctcggtct gtcacccagg ctggagtgca atggcatgat 345180 ctcggctcac tgcaacctcc aactcccggg ttcaagcgat cctcctgcct cagccttccg 345240 agtagctggg attacaggtg cacgccacca tgcccagcta atttttgtat ttttagtaga 345300 gacaggtttc accatgttgg tcagagtggt ctcgaactcc tgacctcgtg atccacccac 345360 ctcagcctcc caaataaagc tcagcggtac attgctttaa caacattaaa ttgcaaggtc 345420 tatgtctcat aagagagcag gttaggacta gtctccacag gtccagtggc aatatcctta 345480 gtatcataaa caatacactc agaccattaa gacatactgg aaacaacatt ttggttgcca 345540 ctatttccac tgatgtgtac cagagacata tgaagacact tttacacaag ttgcataata 345600 aaaccaaagc aatgaataaa ctttgaacat ttgtgactaa atgataccta cattgtattt 345660 aattatatta tgcatatata ctgcatttga ctctcactcc aaatatgtta gaaacttttc 345720 atattaaaat ataaagctct attttcattc aatagatgat ccttagttaa ttcaatgagt 345780 cccattcatt gatgaattgt ttgccttcat tttgtgttaa tttttttgtc atttttttct 345840 tctcatgagt tttgttacct gatatgataa cctttcccag tgaaatattt taattttatc 345900 tagctataca ttcttctaga tcttttttgg ttataggcat ttttagtttt caatctgtga 345960 tttttctgta attaattttt gtaagaacta aattaaatat tatctttttt gaattatctt 346020 aatgtctcac atcacttatt gagtagcctt tctatcctcg ctagtttaat attactgcaa 346080 tttttacaaa ttgaatagcc atgtgcattt gtatctattt ctacctctag attctactga 346140 actgtccaga tatgaaataa ctacaataaa caggctatta caatattaat aaactatctt 346200 aattgtcttg ttactatttt ttctgttaca gcaaaataag ggtagggacc ttcagatgga 346260 cagattagcc tggattaagc aggtaagccc aataaatcac atgagtcatt gactatggtg 346320 aacttttttt ctggctggga gcaagagacg caaagatgga aaggttagag agatgctatg 346380 tgagaagact caatattctg tctctggctt tccagatgga gaagccgagg atcaaggatc 346440 gggccaggag ccaaggaata ctgccacctc tagaagttgg gaacggccct cagcttacag 346500 ccactaagaa aagggggatt ttggccctct agctgcaagg aatctaattc cacttgaatt 346560 aacaaggaac atccaggcag gaatgtagcc ctgacaacac cctaatttag gccagtcagg 346620 cccggacaga cttctgaccc acggaattct aaaataattt gtgtttctta aaccatcaaa 346680 tttgttgtaa tttgttatgg tagcaacagg aatcaaatat acctctctac ttttacaaga 346740 tattgttgtc tgcagcctgt ttgaagtcgg tgactaaaca cagctggtta ctatggcagg 346800 cccattctga agagttgcag gacaccctcg gg 346832 <210> 39 <211> 10584 <212> DNA <213> Homo sapiens <400> 39 cccgcagctg cgccccaccc gggccaccaa gcacggtgga gggggaacag gacactgcct 60 tcttgcttct cttctctctg gcatctccct cttccgcccc cttcctttta cccttccctg 120 ttttcatcta ctcgctgtga gcttctctct ccttacaaac cctttttcct gggctagaca 180 ctctgggtca agttcagagt atcgtgtcct caaggcctct tctctgcaag aaaccccgat 240 gattagaggg ctggagggaa aaactcatgg ggaagaaagc atggggtgtt ttcaccaaat 300 gccaaattca tctcagtttt attgcgcgcc aactgcatgt gaggcaccag gtgcagggag 360 acaggagaca gtatccgagc tccaccatcg cggtatagag ggtgagacga acagtaacca 420 agaaattaat agaataggca ctaaagggct tggcgaatgg aggctccacc acactttcct 480 ggagcgagtg agttggacaa gatgaggttt ctctgggatg gcgatgtctg agctggggcc 540 agaagtaaga gttggggatt caggggtccc atcacctgtg tgtgctggaa ggaaatcttt 600 gctattctta gcacggtggt gtggggccag ggcgaggcag gaggtggaat ggaaataatt 660 aaataggaag caaaaattat cagtccacag gatcctggtg tgatctgcga gggagaggtg 720 gatgaaccca ggagtgaggt ccttctgctt ggaggttcct gctctgcact catccaaaca 780 cccagcagga aaccccagtt tactgcaggg agaacctgaa gttgtatact cgttttggct 840 acctttgccc ttcagctggg aggaaaagca gagtttagaa acaagtatac tctccgtctc 900 tgggactgtt tcattatttg taaaataggg tggctgaagt tggaaattca cgggtccttt 960 cccgttaggc gatttgagga gaaaggagca tttggacact atggctccct cggttttccc 1020 acgcctaacc tggaagaaag ccatcggccc agctgcttgg ggggctgccc cctaactagc 1080 aaccttggtg acaccagatc gggtgttttc agcttctggc ttttggtgag ctggacggtg 1140 ggagcacgtc tgtccgtggg gtggcttagc caggtcgcag gagtgccgtg agcgggtcag 1200 gcccgtaatt tccatcttta gtcaggagct agatttctgg ctagctctat gtggccagtt 1260 tgtcctaggc cagaagacgt ctgagaatag atgttacgac tgaagcttgc aagaaggccc 1320 ggggaaaaga gcagcttctt ggtcctaagc ccttttcaaa gtaagatgtt ttctctttca 1380 ctgtatgtcg gaagctttcc tcctgccata ggagtttctg cgcgattttt gtccgctgag 1440 acacttgaga gagccgagca gcggacagcc tcttggcctc gggaagccac agaattccaa 1500 ggacgctcac agtttgacaa gagcctgctg gagccaggtg gctccttttc cttggaacaa 1560 gaccgtgaga caacagccct gtcccagccc aggaagctgg ggtctcctgc accgctgtca 1620 ggccgctgct gaggagctct gcgtgccgca cacttaaggg ctctccggac ttcgacccca 1680 cacgcagctc gagcaaaggg atcttttgtt gatacctcgg atagcatccc ttccgcgggt 1740 tgctggaaca gcagagtctc cttttgggga gcagctctgg gaccgtgccc gttgggcact 1800 tgcggctcct gggaaccgat cgaggggagg ggcccttcag ggactcccgg gacaaatctt 1860 gggcgcataa cgcgaaccct gagcacaaaa aatgagccag gccctcactg ggtgagctcg 1920 ctacagcccg cagacccgcc gccacaacct caggttcagc gccaggggac gccaggggct 1980 tggccagtgt cttcggcctc ggcgagccag gttccacgca acctgggaca aaacagtctc 2040 ggaggctgag cgaagcgccc cgagcctcac gcttccgcat tcaggttgtg cttggcgagg 2100 gtagaaagta cttcccacca cctaggccac agccggacgc ggcggcccag gccgcaattg 2160 ctgcctagag cgcagacagg gagctcgggt cgcgtgtctg ttttggagag tggcgggctg 2220 cggccgccgc ggaggatcct gggggattcc aagcgcggca ctgggccggg gtgcagagct 2280 ggggccgcgg tggggagggg ggcgcgctct cctcttcccc tacttccccg gaggttaatt 2340 ccgacaagtt ttgcaggcgc tcagtggcac cggcgggggc cggaacgcgc gcgctccagc 2400 tgcctgcaga ccccctctca agaaaaacag atcgtgtaac caccctggca ccaaccagtc 2460 ggtttcaagt ttccgcgagt aatttttttt tgttgttttt aaacaactac tgcactatcc 2520 aaatattggc tggcgctcag gacgctggca ggcaaatcat tgccccgggc ttagtgtaat 2580 tatctcaggc gtatttggtt taccccttag gcaattgttg gcgacgctat gctaggaaga 2640 ggggttccat gcaagctttt attgcgttta attggctcta tggaggggag taaaaaaaga 2700 tgtggaactt taggagcggt tatttattca ttctttctcc tccatgcccc cagcccctgg 2760 agggtctcac gcgctccttg ggctggatct aggccaggcc ttcccacggc ttctgcggac 2820 agctgtgccc agggcgagga ggaacacaag ttaccgatag ggctaggacg acgtacagcg 2880 ctagaaaaaa ggcaaaggtt taggcgcaca tctcaatttc catgggttct ccctttacgc 2940 actgacttag ctgacgtgcg gaaggttgcc tgggttagtt acgtttgggg tcctcccagg 3000 agccttcctg gtcacgctag cctggcactt gcctgacctt cggctgactt ctcggcgcat 3060 acttttccca gacgaaactc ctaaagtgga tttgaagagg gtaggagaaa gccagcccca 3120 ggactcggaa acgtggcttc cagctcgagt ccaggcctgg atgaccctgg aggcatcatt 3180 tcaccgcttt gggcttcttt ttctttccag gaaatactca gtagtcagaa ctgcgccttc 3240 gaaggctcca aggagttgag gtttgaagct gtgatctcga cggtggagtg gcgctggggg 3300 tctgggcgct cggagcgggg agctcaggag ctgcgcagct ggggacgctg cagggcagca 3360 gcgccacccg tcaacccctt ataacgtttt aggaatccgt cgcctccagc gtcaccaacc 3420 cgacctgaca tctctgcgaa gtgcatccct gccccgtttc cgacccgtcc agtccccgcg 3480 ccttgcccgg caggcgccca ggacacaggt ttggctccgc cctacttgga tttgagtgca 3540 taagctcgat ttgacttttc ggaatgcccg agggtggagg gcagaaggga aaagcctgag 3600 gtcaggggca tttatttctt ggagaaaaaa agcactggcc ttgaatttag gagacgatac 3660 tcgagctcca gcttcgccac ctactggctg tgcgactgcc tcttctctga gcctcagttt 3720 ccttttctct aaagtggcga tgaccctgtt gccttaaaag tgcgattctg agacgtggga 3780 ttttgagagt gactgctgga atactttgat ccagtaaacc tctatcaaga gcctactgtg 3840 tgccaagcgt cagaaaacgc cttgtaaagt gtgaagcatt gtaaatacat aagatgctat 3900 tatcgttttt gctgttagaa gtcatcatct tttccttcct ccaaatctaa ttgtacctaa 3960 gaagagctcg acaaaatgaa gcccgacggc ggtacatgag cgggtggatg tatctggcgt 4020 tggagtggtc agccgcgggg tgcacacggc tttctctcgc agtgccaccg gccaagaaag 4080 acagcccagc tttcgtcccc caaagtttct agcacctccg ctcgcgggcg agactggctg 4140 ggttgtctga gccgtaggtg tgcgagtttg agggaaggag gatacaaggg ggtccagcca 4200 gcagcggaga gccaggggat agcgccgggc cgcgcaggct cagggttgcc gtgccagcgt 4260 cgctccacct cgacattgac cccaggctct cgtctgaccg aaactcactc cgcaaagacc 4320 ctacgtgctg cccagagtca gaaacctgac ttttaaatct ccactcttcg aggcgagatt 4380 cgtctcgaac accgcggctg tgtacactgc ctgtggcccg gggcgcgcaa tcagcgtgga 4440 gatgggaagc gtttgtgtca ccctagcaga gcaatttccc ctttacagtc cacccgcgcc 4500 tcacacctct tggccaacat ccagaagctt tcctacgggc cgtgtctgtt taggtagcgg 4560 ccactgacaa ccataaccac caaataaata accaacgatt aaaaattaaa taactttctt 4620 gcgctccctc cgacgactaa taacaaagac tccgcacatc agcaaccagg tgtcgcggtt 4680 aaactcctga cagtaactgt cttccttttc agccagccag ttctggaata cattacatta 4740 attaagtctt tggtgattta gcctccttgg agagaagtcc aacaatgtaa ttaagagcat 4800 actggctata ttagatatga atattcaaaa cagtgtcaat taattagcca acagatctag 4860 ctcactatgc ttcgaaagcc cctgaagtcc tctaagatac atttaaaggg tcatcggcgg 4920 ggaaaggaga ggggggtaaa gaatattaaa gaggtgggtc cagatgatct cttcgttcca 4980 cataaacatt ttctaatgat ggcgatttat aacgtccctg acatcacata ccgcaccttt 5040 gggcacgtgg gtgcccgccc atgtctgtgt gtgtctggtg gtggtggtgg agttgggggg 5100 gcggggcgga tgttgttgat ccatcagagc aaagatcttt tataattaaa gtgaggaggc 5160 atccaactgg aagggccttc ttagaggcac caagaggcta tccattgtac atcctctcag 5220 acatgttaga aagataaata ttaaatctgc tatcacaaag ggagctgtta aatagatact 5280 aagctgatat gcataaaaaa ttaattaggt agttttctca gcatcaaact cctggacaaa 5340 taactacttg taaagtacac cttctgggca tattgaacat atgctggaat tatccttaat 5400 tgactaatta cataaattac tcattaattt tacagcacat caattataaa agatatatca 5460 attaattttg cataaattaa gactggaatc tccctccccc caaaaaacac aagagagagg 5520 ctgctgtaac aaaatatgca gagaggggag aaaaacaatg tttgtgtatt tgtagattgc 5580 aataataatt tgttctgctc tgggcagaga ttttcttaag gaaaaacatc cttggcaatt 5640 aaaatagtcc taaagaccac ttacgatgtg atcatgcgtg caccaaggcg aaacagacca 5700 tttaaatcaa ttaggactgc tctgatggaa aatgagggcc tggcaatgac aaagtactca 5760 gacattagta atcacaaatg atttaacatc cacattaaat gcctgactgg gtagtaaggc 5820 ttattttcct aagtcagcag ggtgcccgta acgaagttat ctctgggtat cccaaagtag 5880 acttcggcaa cgatttcaca cacaattggt ggaaattaat ttgacacctc tcttcaacct 5940 aactcctcca gcctgctcgt ttcgggctct cctaagcggc tgttggcctc ctcacctcct 6000 ccctcgtttc cttaaaaagg tcattaaatg cttcgtcacg agcccagccg tggggccctg 6060 ctccttctgt tttgggtttc tcctcccctg gtgggactgg cggctttcag aatacagact 6120 gtgtctcggc ctaggctagc gggtcgagaa ggtgatttcc aaggggtgag caaagtctga 6180 gacccccggc tccttgactc ttcctggccc gccctccgca gtctgccagg ctgaggctga 6240 aaacacgagt ttccagaaag gctttaggca ggctgcgggc gccgggaggg aagccgggag 6300 accgctgcgc ccgctgcgcc cgctgcactt tggcaacgag gcctgcgtga ttttagtcag 6360 cagggggcgc tgtctcccct ggtcgccgcc ttagagagga agccgccttc ggtgcgggtt 6420 ttctccgcac agcgatggag gtggagagat gtgagtttcc tggggtagcg gcacttctag 6480 aaatgccagg ctatggttca ctggtttccc ttctgtgtga aaaccccaat ctaccttgat 6540 ttgtgccaac catctgtaat gcttttcata gataacttta gacaacatca aatcaaacgg 6600 tacttgaaat acatcccaaa tttcctcttg gaagttgtga acttcgaagt tgcacctaca 6660 aatatagagg tgcttttcca aaagaaacaa aaacttcctt gaaaggaatc cgtagtcatt 6720 atttaatgcc agccccacgt gtgtattgat aattattgac aatagaaata tagaattttc 6780 tatgttgtta agaagccttt caacgatata agtgggagat tcaagttata tagaatcata 6840 tggttcaaaa attttgtttt tatattcttt taagtatttt gtattcatag tgatcattca 6900 taactctgaa gtaaaataaa tcagaatgac agacaactgg atgttggaga aacagaaagg 6960 ttttactttc aagagatgcc tagtttggtg gatagtaagt ttatgatcag cagattccca 7020 atcccacact cataaattgg ttgtgttaaa aatactttgt tttaaaacca ctatgtattt 7080 cactcaaagt gaaatttccc ctaggaataa tactgtaact ggtagatagg atcccagcta 7140 gttggtactg ttccgcttta agtcctgtta aaccagtaat gtatctaaaa atttgaattt 7200 ctcctttgag actgatcaca accctaaaag gtccttttct tatccccttc tgttgctagt 7260 ctccaaagat actggctccc acccccatat tggaccatgc cttctggaat tcatgccctt 7320 gtgcagtttc ttctcatatt aaatctgacc cagtcccatg ggaacaagta gcatgtggca 7380 gaagtggtgc agtatgattt caagccaaat cagaaggacc cttgcagctt ttgccttgcc 7440 cttttaaaac acacactctg gggtggtggt ggggattggg gggtgggggg gcagtgccag 7500 ccaacaggta agaagtccta cggctcacac tgtgaggaaa tccagtttag ccaaggagag 7560 agagagagag agcttggcgg gggagagaga gagagagcgc gcactcttgg agagagagag 7620 atgcctgatc agccaccagc tctgccaacc atcccaagtg agatgtcata tgtggtgagt 7680 aaaggaactg tcctggatgt ccagtccagt taacttctag ataatttcag cctcagttct 7740 acctgactgc aactgcatga gagaccttag tcaataacct ccctgctgag ctcagtcaat 7800 ctacagaaac gcatgggcta acaaaccatt gctgttcagg cattatgttt aggtgtgatt 7860 tattacacag cagtagataa ccagaacata cattgtcctg tctcccattc tttttcctat 7920 actatttttt cttgaatctt atttctgcta cagtttgaat ctggctactc atgtgagcta 7980 gcctgggaat ctgaacacta gttagaatat cgaggctggg attgtgtgcc aaagagattg 8040 gcaaggagag tagatgaagg agactgcaac ataattagac atttctattt acgcttagga 8100 aacagttacg agaaactaaa tactgctctt cctcggagct tctcaggggc tggcactgga 8160 ggatacaact gtcagtaagt tcctaagtca cgtgctcaaa gagaagtgcc tctattagaa 8220 tttctatctc aatcatgtgc attgttttaa ttaaaggttt ttttctaata ttctcaaaca 8280 acagatatat aattgtattt atagtatgga agacaattaa attagaatct ttttcaagat 8340 aaaaatagtg tctttgaaat tgctcacatt tctagagaat aatggtgcta tgatcagtag 8400 tttctgttcc attagcttct cctttccaac taggcaaatc aataaacttt atagtgtttg 8460 tttttcacct tttattgcca ccatttattc aagtgcagac ttgccattgt aacttgtact 8520 tctggatagg cagtcatata tttgctttgt tatattgata agattttttt tttttttttt 8580 ttgagatgga gtctcgcttt gtcatccagg ctggagtgca gtggtgtgat cttggctcac 8640 tgcaacctcc acctccctgg ttcaagcgat tctcctgcct cagcctcctg agtagctggg 8700 attatagaca cacaccacca aacccagcta atttttgtgt ttttagtaga gacagagttt 8760 caccgtgttg accaggctgg tcttgaactc ctgacctagt gatctgcctg ccttgacctc 8820 ccaaagtgct gggattatag gcgtgagcca ctgtgcctgg ctaagttttt tttttttttt 8880 tttttttttt tttagcgcaa cttgtgctgg tccttttgtg aagcaagaat attcaagagt 8940 ttatagatat aaaaatatcc tcagctctta ctaaagaaaa atcatcttcc tattgttcat 9000 tgtagtctca tctttcagat ggaaaaacag ataaaatccc agacattccc aaagaatggg 9060 cttcataagg ttcaagtaga tagctggtat ggattttaat tgtcttctaa atcatccttt 9120 atgcagggaa agcctaacat gtttgagtga ttactttttg tttggcatcc aatagtgcca 9180 aaatggactt tggcatcaga ctgatttggt taattttagg tgcttttttt tttttttttt 9240 ttttgagaca gaagcttgtt cttgttgctc aggctaggtg caatggcatg atctcgactc 9300 actgcaacct ccacctcctg ggttcaagag agtctcctgc ctcagcctcc cgagtagctg 9360 agattacagg cacccaccac cacccctggc taatttttgt atttttacta gagtcggggt 9420 ttcaccatct tggccaggct tcagtcttga actcctgacc ttgtgatcca cccacctcag 9480 cctcccaaag tgctgggatt acaggcgtga gccaccgagc ctggccctag gctcttatta 9540 tttagtgagt gaccttgggt atgggaccta acttttatag cctcaaatta ctcatatgta 9600 aaatggggat gatagaacct gaaatagagt gattttgatg attacatgag atactggacc 9660 taaaatgcac acggcgaatg catcataaat gttagcaacc tgtcacttac tcaggagatt 9720 tctggggtaa attgctgttg tattttcact tgttgatcac tactttggaa aggttaaaag 9780 tgtactttta aaaatctcag ttggcagggt cttaagatga cttgaatcta tcaggttgta 9840 cctgaagaat ctggagtatc cttcctcatc taattctcca gtttttctcc cctcgaattc 9900 ctctgtcaga agcacaactg taagaacacc accacttctc tgctcagaaa ttttcaatag 9960 cagtttggag atgaccttag gcaagtgcac acctcttagc ttcacattca aaaagccttc 10020 tacaattggg cctctgggtc tatccttcta gatttatcac attccctctg ctcctaccaa 10080 aggaggtcag ttgcatgctc ttccgaatac atagccgcat tttcccccct gacttcactc 10140 ccattgttca ctctttctga aatgtgtatc ctcttctatt tttacctccc caaactctac 10200 tcattcatca aataagacct cattcaacaa ttgcctcctc cacaaagcct tctgttacct 10260 ttccttgtag aatcatcttt ttcctctaag tgtctagaac atgttgttta cacttcaatt 10320 atgcaacaat cacaacctgc ctttcttatt aatatgcaaa ctttatgaaa gcagggatca 10380 ttttttatcc aatttttgtt tgccacagta gttagtacag ttaaatcagt gcttcccaaa 10440 ccatctttga aaaagaacca gctttgaaaa aaaaaagcaa tctgttgcag attgagatgt 10500 ttgtaaaaca caataaaaat gaaagattag aaaactaaaa taaaaatacg gggcaaaata 10560 caagcccaaa tgtctctctc tctt 10584 <210> 40 <211> 4241 <212> DNA <213> Homo sapiens <400> 40 atgtgccacc acacctggct gattttttgt atttttagta gagatgggat ttcaccatat 60 taaccaagat ggtctcgatt acctgacctc gtgatccgcc cgcctgggcc tcccaaagtg 120 ctgggactac aggcgtgagc taccaagcct ggccaagtgc aacaagcttc taaagcaaga 180 atgtggactc cacgttctga tttgcccact tactagttgt gtggcttcgg ttggacttgt 240 gttagtcatt tttgcttctg ctcctctgag ttctcttatt tttaaaatgt ggataatggt 300 acctagctca aagggtttct gtgagagtta actgagttaa tcactgtaaa gtacttagaa 360 cagcatgctc taaagggaga agaagaggtg tggagaaatg gagtagggtt gaagaaactc 420 ctaaagctcc cttgagttca gaagggagat gaggccagct gggtatagtg tgtgtgtgtg 480 tgtgtgtgtg tgtgtgtgtg tgtgtgttta ggggaggttg gtgttggtct cagtgttatc 540 taagtgtgtt gtacaggcaa ggtaactgga gaaaagggca aggaaaggca agtcttaaaa 600 tttcttagaa agacctttca caagccaggt gcagtggttc atgcctgtaa tcccagctct 660 cagagaggca gaggcaggag gatagcttga gcccaggagt tcgagacctg cctgggcaat 720 atagagagac cccgttctcc acaaaaagga aaaaaaaaat gacaaaaaaa aaagaaagac 780 ctttcaagaa taatttctac caatgagtgg atcaagaaaa tgtggtatgt atgcaccagg 840 gaatactact cagccataaa aagaatgaaa taatgtcttt tgcgacaacc tggagggagc 900 tggaggccat tattctaagc gacgcacctc ggaaaaggaa aaccaaatac catatgctct 960 cacttacaag ggggagctaa gttattagta cgcaaaggca tacagagtga tttaacagac 1020 tatggagact cacaaggggg aggataggag gggcacaaga gataaaaaac cacatattgg 1080 gtactacata ttgggtagag tgacaggtgc gctaaaatct caggcatcac tactatacaa 1140 ttcatctatg taaccaaaaa ccactggtac ccccaaaact attgaaatta aaaaatattt 1200 ttaaaaaaga actatatcca cctgtggcag agaaaatggg gtatagggtc tggacagaaa 1260 cagacctgca ttctccagag accaagaaag ctattaagag agtttaattt ggttctatgt 1320 tagtgtggtg tcaaagcagg gtgaatttgc attaaagaag tgtgaaagtc taaaggcaaa 1380 gtaggtcatg agacacgaga attaaatagg gagatatgga gactgtttaa tgatttaaac 1440 ctctatcaag cgaattgaac aaagagagac tgtttctctg tgtttgcatg gtcatggtca 1500 ttgtgatcac tgctcacgtt ggttgcagca ggctgtcttg ccaatggctg ctatagcagt 1560 aacaggggac tggtcagcaa atgtgcattg catcaatgac atggagccca tgccctttca 1620 ctggcttgtt ggtagtggtt gcatggggct ggggaccccc tcttggatct ttattgctga 1680 cctcacttct ctgtatcaca caagtctcaa gaagatagag aagacaataa tacttaataa 1740 aatgagaaaa ctgttttatc aatatgttaa gtgaaaaaag cagaatatga aactatgtat 1800 atgaacctaa ttggttaaac atatgtgtag aaaaatgact gaaataaaac agattaaaac 1860 agtaaataat agttgtctaa ggatggaaat tacagatgac aatctttcct ttatatttta 1920 tatcttcttt gctttcattg ataaaaatgt tttgcttttg caattggaaa aggtgaaata 1980 aatgtaatta acttataaga aatgtaagtt cttccttgtt cagagcttta cacattgctc 2040 agcaacaaat ggttgtttgc taattggtat gtaaagggca ataaacaagt taattgctgg 2100 ctacattctc gaatagctag aggaagttca aagcttctca accttatttc agctccaaga 2160 aagaggacct ctgatgtggg tcaaagacct aatggagtcc tcaaaagccc accatgcgcc 2220 atagtgggtg gaggctgggc aggagggaga agcttcaaag ccccctcttt ccatgacatg 2280 cttcttcttc acatcaattt ccatcacttc cctttccctc tctcagctac tgttaaaaga 2340 tggacttttg tattaggttg ctggggttgc caaagtaaag tgccacagac ttaaatcaca 2400 gaaatttatt ttctcaaaat tctagggtct agaagtctga gatcgcagtg gcagcagggt 2460 tggtttcttc tgagacctct ctcctagctg gcagatgccc tttttcctgt gtcttcacat 2520 ggtcttccct ctctgtgtgt ctgggtccga atctcctctt cttatgaaga tatcagtcat 2580 attggattag aacccacact aatgacctca tttaacttaa aggctctatc tccaaatata 2640 ggcatttgga aatactgggg gttagggcca caatgcataa atttttgggg gacacagttt 2700 agcctataac aggattgaag tgtctccttt cttaaggagc catgtctctg ctcatagaga 2760 ttcaaaagaa agccaaggtt gggcttagga gaaaataagc aaaagtagag gctgcttaaa 2820 gtttttgggt ttggtatagc ccaccaggtt aagaaatctg acaggaattt gagtaatctg 2880 aatccattct gcgtttgccc agagtctcct tctggacaca tagccctctt aaatctctgg 2940 ctgcattgag gctgcttgag aatttgaaat ctcagtcatc tcctccttgg ggacatggtg 3000 aatatgtcat tctgttgaac tgatcaccat attatcggat gtttctacaa aagcaaaaca 3060 gagttgagag cagaaatatt agaatcttag aaagtgacag gggctggagg atgaagaggt 3120 ggcagggtaa aaggatgggg tactttggtc atattatcct tgataggctg gttgacattc 3180 tcattctctg ctaagaacaa gcagaagcat cccaggaaac tcttatggga ctttaatgtg 3240 atgaaatgag agagattatc tctctcctct gcctaaggga tgactatcca tagaatgtac 3300 tcagacttct ttccaatcac agagataaat cctgaaagtt ttgcagtatg gtactgattt 3360 ccttgaccta ccagagtcca ggtctataaa gtttgccttt gcccagccag cagatggtgc 3420 catttttcta ggaaattgag ccagattcag cttgaactgt catttggcct ttagtgttgt 3480 aggcactgtg ctcacagcat gttgtatagg gcttcacagg taaccagttt ctgttcgagg 3540 aaagtctagc gctcttacct gcagttgaac acactgaaat cttcaagttt ctcagtttaa 3600 gtgaaaactt ttatttttaa aatttcggga taattagaag aaaatcttag tatttccttt 3660 agaaaaatct tcccccaccc ctcaactctc tctttctctc tctctctctt tctcgcatct 3720 tattccaaca taccaggtgg agccatctca tctttccttt gaaaggccct ctcacaatcc 3780 ttcacgctta cacatggtgg gtggactaaa ttctatagtg aaattgtagc ttttgaggaa 3840 tgagtacttc tgaacagctg ctttactttt tgggggacat ctagctgtgt atttatcttt 3900 taaggtataa atgctttcct tcaaaaaaat atatacatat tctgaaatat ttggaagcca 3960 gttgcagatg ttatgacaca tcagccctaa atattcagca tataactcct aacaataaag 4020 actttcttct atgtaactgc taaaccatga ccatatctaa gaaaatcaac agtaatttcc 4080 aagtattact taatatccat ttcatattca aaatttccta gttatttccc atataccttt 4140 catagctggt tttattcaac tgcatccaat caaagctcac acattacatt tagttgtttc 4200 atccattcat atatacatat atatgtgtgt gtgtgtgtgt g 4241 <210> 41 <211> 601 <212> DNA <213> Homo sapiens <400> 41 cctgtgcatc taatttagtg gggggcagac ctgtttcaca agccaaaata acaggctgca 60 ataactgagg attttatata taccctgacc aaagaagttt gcattctcat agcaccatct 120 agtggaaatt tggggatttt tgttttacat cgaacagcct aaaatggaga tagtttatgt 180 tattatgaca gggagagaag actgcacgat ttgctaattg aggtgcaata cagacaagta 240 aacaaaaaca ggaaaaatgt ggcttatgtg aaagacattt tttaaccata tacaacatgt 300 tctataaaaa cagagcaaag ccgttagctg aggaacttgt gtgcacaaag aaatatgtac 360 aaatagcttt tccagaacag tctagtaaaa atatgtagta aaagtgggaa gattatgtta 420 tatagaaata tatgtttatg tgctgtgttt atatgccaca gcctcaaacc ttcttataac 480 ttattaacaa ttatatgaaa atataggaac aaagctcatg ttctgtatga atacaacagg 540 attcaaataa ccacatacat tacaaagagt tgaataaatt gaattctcta ttttctactg 600 t 601 <210> 42 <211> 252 <212> DNA <213> Homo sapiens <400> 42 attgtggaac tgctctttct ccctgcgatt cagaggggaa aagataaagc cacacagccc 60 tggggcctct tgcttaagaa cacatctcag tttaaccacc aaggccgtta tgataacaaa 120 tgtcagtatg gaggtgtgaa catcaggggc tattcaagga cgcttctctg atcactgcca 180 tgtctatctg ctgtgatcac gactatttta taaacaccct tcctacccaa tgccatcaga 240 attttaggga cg 252

Claims

다음 단계를 포함하는, 전립선암의 진단 방법:
a) 환자의 샘플에서 적어도 두 개의 핵산의 발현 수준을 분석하는 단계로서,
상기 적어도 두 개의 핵산은 적어도 두 그룹의 핵산에서 선택되고, 상기 그룹은,
그룹 1: 서열번호 1
그룹 2: 서열번호 4, 5, 6, 7, 8, 9 및 10으로 이루어진 군에서 선택되는 Ensembl 유전자 ID ENSG00000245750.3의 스플라이스 변이체(splice variant)
그룹 3: 서열번호 26, 27, 28 및 29로 이루어진 군에서 선택되는 Ensembl 유전자 ID ENSG00000255545.3의 스플라이스 변이체(splice variant)
그룹 4: 서열번호 3 및 11
그룹 5: 서열번호 12
그룹 6: 서열번호 24
그룹 7: 서열번호 36
그룹 8: 서열번호 38로 구성되고,
b) 상기 적어도 두 개의 핵산의 발현 수준이 소정의 임계값보다 큰 경우, 상기 샘플은 전립선암 양성으로 지정되는 것을 특징으로 하는 방법.
제 1 항에 있어서,
상기 적어도 두 개의 핵산 중 적어도 하나는 그룹 1의 서열번호 1 및/또는 그룹 2의 서열번호 4, 5, 6, 7, 8, 9 및 10에서 선택되는 것을 특징으로 하는 방법.
제 1 항 또는 제 2 항에 있어서,
적어도 5 개의 핵산의 발현 수준이 분석되며, 상기 핵산은 적어도 5 개의 상이한 그룹에서 선택되는 것을 특징으로 하는 방법.
제 1 항에 있어서,
상기 8 개 그룹 각각의 적어도 하나의 핵산의 발현 수준이 분석되는 것을 특징으로 하는 방법.
제 1 항 내지 제 4 항 중 어느 한 항에 있어서,
상기 샘플은 전립선 조직, 생검 물질, 림프절, 소변, 정액, 혈액, 혈청, 혈장, 혈액 또는 림프액 내의 순환 종양 세포, 전이를 포함하는 것으로 의심되는 임의의 조직뿐만 아니라, 엑소좀(exosome), 마이크로베시클(microvesicle) 등과 같은 소포체 및 아니라 전립선 종양 세포에서 유래된, 자유- 또는 단백질-결합된 RNA분자를 포함하는 전립선 종양 세포 또는 이의 일부를 포함할 수 있는 임의의 소스로 이루어진 군에서 선택되는 것을 특징으로 하는 방법.
제 1 항 내지 제 4 항 중 어느 한 항에 있어서,
상기 샘플은 소변 샘플인 것을 특징으로 하는 방법.
제 1 항 내지 제 6 항 중 어느 한 항에 있어서,
발현 수준의 분석은 표지된 프라이머, 표지된 프로브 또는 형광 검출제의 형광을 측정함으로써 수행되는 것을 특징으로 하는 방법.
제 1 항 내지 제 7 항 중 어느 한 항에 있어서,
발현 수준의 분석은 qRT-PCR에 의해 수행되는 것을 특징으로 하는 방법.
엄격한(stringent) 조건 하에서 적어도 두 개의 핵산에 혼성화하는 적어도 두 개의 프라이머 또는 프로브를 포함하는 전립선암 진단용 키트로서,
상기 적어도 두 개의 핵산은 적어도 두 그룹의 핵산에서 선택되고, 상기 그룹은,
그룹 1: 서열번호 1
그룹 2: 서열번호 4, 5, 6, 7, 8, 9 및 10으로 이루어진 군에서 선택되는 Ensembl 유전자 ID ENSG00000245750.3의 스플라이스 변이체(splice variant)
그룹 3: 서열번호 26, 27, 28 및 29로 이루어진 군에서 선택되는 Ensembl 유전자 ID ENSG00000255545.3의 스플라이스 변이체(splice variant)
그룹 4: 서열번호 3 및 11
그룹 5: 서열번호 12
그룹 6: 서열번호 24
그룹 7: 서열번호 36
그룹 8: 서열번호 38로 구성되는 것을 특징으로 하는 전립선암 진단용 키트.
제 9 항에 있어서,
적어도 8 개의 프라이머 또는 프로브를 포함하고, 상기 적어도 8 개의 프라이머 또는 프로브는 엄격한 조건에서 상기 8 개 그룹 각각의 적어도 하나의 핵산에 혼성화되는 것을 특징으로 하는 전립선암 진단용 키트.
다음 단계를 포함하는 전립선암의 진단 및 치료 방법:
a) 환자의 샘플에서 적어도 두 개의 핵산의 발현 수준을 분석하는 단계로서,
상기 적어도 두 개의 핵산은 적어도 두 그룹의 핵산에서 선택되고, 상기 그룹은,
그룹 1: 서열번호 1
그룹 2: 서열번호 4, 5, 6, 7, 8, 9 및 10으로 이루어진 군에서 선택되는 Ensembl 유전자 ID ENSG00000245750.3의 스플라이스 변이체(splice variant)
그룹 3: 서열번호 26, 27, 28 및 29로 이루어진 군에서 선택되는 Ensembl 유전자 ID ENSG00000255545.3의 스플라이스 변이체(splice variant)
그룹 4: 서열번호 3 및 11
그룹 5: 서열번호 12
그룹 6: 서열번호 24
그룹 7: 서열번호 36
그룹 8: 서열번호 38로 구성되고,
b) 상기 적어도 두 개의 핵산의 발현 수준이 소정의 임계값보다 큰 경우, 상기 샘플은 전립선암 양성으로 지정되고; 및
c) 하나 이상의 전립선암 치료제를 상기 환자에게 투여하는 단계.
제 11 항에 있어서,
상기 전립선암 치료제는 도세탁셀(Docetaxel (Taxotere®)); 카바지탁셀(Cabazitaxel (Jevtana®)); 미톡산트론(Mitoxantrone (Novantrone®)); 에스트라무스틴(Estramustine (Emcyt®)); 독소루비신(Doxorubicin (Adriamycin®)); 에토포시드(Etoposide (VP-16)); 빈블라스틴(Vinblastine (Velban®)); 파클리탁셀 (Paclitaxel (Taxol®)); 카보플라틴(Carboplatin (Paraplatin®)); 아비라테론 아세테이트(Abiraterone acetate), 비칼루타미드(Bicalutamide), 카소덱스(Casodex), 데가렐릭스(Degarelix), 엔잘루타미드(Enzalutamide), 고세렐린 아세테이트(Goserelin acetate), 류프롤라이드 아세테이트(Leuprolide acetate), 프레드니손(Prednisone), 시플류셀-T(Sipuleucel-T), 라디움 223 디클로라이드(Radium 223 dichloride) 및/또는 비노렐빈(Vinorelbine(Navelbine®))을 포함하는 것을 특징으로 하는 방법.