KR20170090830A - Cosmetic composition - Google Patents
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- KR20170090830A KR20170090830A KR1020160011687A KR20160011687A KR20170090830A KR 20170090830 A KR20170090830 A KR 20170090830A KR 1020160011687 A KR1020160011687 A KR 1020160011687A KR 20160011687 A KR20160011687 A KR 20160011687A KR 20170090830 A KR20170090830 A KR 20170090830A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
Abstract
Description
The present invention relates to a cosmetic composition.
Atopy is the name given to the inherent irritability of humans for certain kinds of substances that are specific to A. coca in the United States in 1925. Atopy is characterized by asthma and inflammation in the family or by allergens (egg white, dandruff, pollen, dust (Atopic allergen) in the serum or an abnormal reaction to various stresses (temperature, humidity, trauma, mental strain, infection, etc.) many.
Atopic dermatitis has been known to occur mainly in early childhood and is known as fever, and it is known that it occurs mainly as the content of ceramide in the stratum corneum is decreased. Particularly, atopic dermatitis has a problem in that it does not have the ability to maintain the moisture content of the stratum corneum, and the skin is dried and the skin is easily dried, and the function as a protective barrier of the skin is lowered. Therefore, the stimulant- It is common for skin allergies to occur easily due to invasion of difficult antigen proteins and symptoms of pruritus which is difficult to tolerate.
Such atopic skin is severely scratched, accompanied by eczema, keloid, and severe keratinization. These atopic skin have been found to be caused by the following four causes. First, due to a genetic cause, skin barrier that is responsible for skin protection, phosphatidylcholine and keratinocyte, which is a binding substance between cell keratinocyte, which constitutes essential fatty acid gamma-linolenic acid, Second, the view that atopy is caused by environmental factors, as the living environment of modern people is changed into a dry environment such as apartment, the atopic skin is increasing worldwide, and the water holding power is lowered The skin protection function is lost, and it reacts sensitively to small stimulus, and allergy is generated. Thirdly, it is thought that atopy skin is generated by active oxygen, and lipid peroxide is generated by active oxygen, and fourthly, there is an opinion that it is caused by infection with microorganisms such as bacteria, viruses and fungi , It is common to see that the above-mentioned causes are involved in a complex manner and atopic symptoms are generated in recent years.
In order to improve such atopic skin, conventionally, it is necessary to purify the skin to remove the substance which can act as an antigen, to strengthen the skin barrier function and to supply the ceramide which is a cell interstitial substance necessary for protecting the skin from drying, so as not to stimulate the stratum corneum . Thus, in order to improve atopic skin, components such as known ceramide, linoleic acid, vegetable oil or mineral oil, a steroid preparation such as hydrocortisone, or a specific plant extract may be contained in a prescribed formulation of a general emulsification product, Has been mainly used as an external preparation for skin or a cosmetic for enhancing antimicrobial and anti-inflammatory ingredients in order to provide an oil film for preventing moisturizing effect and water loss and to prevent bacterial contamination.
However, such conventional cosmetic compositions have problems such as insufficient effect or skin irritation.
Korean Patent Laid-Open Publication No. 2014-0096810 discloses a cosmetic composition for atopic skin.
The present invention aims to provide a cosmetic composition.
1. A cosmetic composition comprising a calendula flower, an arnica flower extract, a dill extract, a dangguget extract, and a white fly extract.
2. The composition according to 1 above, which comprises 2 to 10% by weight of calendula flower extract, 2 to 10% by weight of arnica flower extract, 0.005 to 0.5% by weight of dorsal root extract, 0.005 to 0.5% by weight of Angelica giganta extract and 0.005 to 0.5% / RTI >
3. An extract of at least one selected from the group consisting of screenworm extract, mulberry extract, octopus fenugreek extract, lotus extract, peony root extract, golden extract, flax extract, okra fruit extract, burdock extract, 0.1 to 5% by weight based on the total weight of the cosmetic composition.
4. The cosmetic composition according to 1 above, further comprising 0.1 to 3% by weight of at least one extract selected from the group consisting of a reed extract and a grapefruit extract.
5. The cosmetic composition according to item 1, wherein the cosmetic composition has the ability to improve atopic skin symptoms.
6. The cosmetic composition as in 1 above, wherein the composition has a formulation selected from the group consisting of a skin, lotion, essence, lotion, nutritional cream, massage cream, moisture cream, hand cream, foundation, body lotion, body oil and body essence.
The cosmetic composition of the present invention is excellent in the skin itching inhibiting effect and has the ability to improve atopic skin symptoms for atopic skin patients.
The cosmetic composition of the present invention is excellent in moisturizing and antioxidant effects.
FIG. 1 shows the cytotoxicity measurement results of the cosmetic composition according to one embodiment of the present invention.
2 shows the results of evaluating the antioxidative activity of the cosmetic composition according to one embodiment of the present invention.
FIG. 3 shows the evaluation results of the ability of the cosmetic composition according to one embodiment of the present invention to improve atopic skin.
FIG. 4 is a graph showing the results of evaluating the skin moisturizing ability of the cosmetic composition according to an embodiment of the present invention.
The cosmetic composition of the present invention includes a calendula flower extract, an arnica flower extract, an abalone extract, a ginseng extract, and a blanched extract.
Calendula Officinalis (Calendula Officinalis) is a perennial plant of Asteraceae, also known as marigold, marigold, or marigold, having a height of 30 to 50 cm and blooming in May to October. It is possible to ship from December to spring if there is cold tolerance and sowing from autumn to autumn. Calendula is well known as a locally applied herb for the treatment of stab wounds and abrasions. It has also been known to be effective in promoting digestion, eliminating indigestion, gastric ulcers, and duodenal ulcers.
The cosmetic composition of the present invention is excellent in atopy skin symptom improvement, calming skin, eczema improvement, moisturizing effect, including calendula flower extract.
Arnica (Arnica montana) is a genus of Asteraceae, with about 50 species found in the southwest of South America. One of the most important species is Arnica montana, a perennial plant that grows in central Europe. A typical species, A.angustifolia, has narrow leaves and orange flowers 2-7 inches (5-7 cm). It grows in the grass of the plateau. It is 20 ~ 30cm in height. The leaves come out from the roots and spread in all directions. Branches are divided at the end, and there are 1 ~ 3 heads.
The flowers bloom in June and July, and they are 6 ~ 8cm in diameter. The flowers are dense and hairy. The involucre is lined up in several lines, and there are no appendages or hairy on the jaws. Anther is dull to sharp, with no tail. The tubular shape is needle-like or scaly.
The cosmetic composition of the present invention improves blood circulation including arnica flower extract and is used together with other ingredients having an effect such as moisturizing and itching prevention to improve the ability of the composition of the present invention to improve atopic skin symptoms Respectively.
Angelica gigas Nakai is a medicinal herb that has dried root of Angelica gigas Nakai belonging to the mountain type. Angelica has better blood circulation (activation effect) that circulates the blood smoothly, and it has strong anticancer effect and blood pressure lowering effect.
The cosmetic composition of the present invention contains the Angelica gigantosa extract and has improved skin elasticity and antioxidant effect.
Lithospermum erythrorhizon is a perennial herb in grasses of mountains and branches of Korea. The growth environment is rich in leafiness of the soil, water is good, and it grows well in the sunlight or on the partly under the tree. Its height is 30 ~ 70㎝. Leaves are pointed at both ends and narrow at bottom. The main stem has branches and many hairs. Calyxes and petals are divided into 5 each in flower stem and white flower. Fruit runs and shines around August to September. Roots are medicinal and purple dyes.
The cosmetic composition of the present invention has excellent moisturizing and elasticity-improving effects, including a drench extract.
The white paper is a medicinal product made by drying the roots of Angelica dahurica Bentham et Hooker or its variants. Gorye is a two-year-old herbaceous plant belonging to the genus Silla. The root contains coumarin-based components such as white, angelic, oxiposidanin and essential oils. The pharmacological action has antibacterial activity against Escherichia coli, Heterozygous influenzae, and influenza bacteria, and shows excitatory action on vasomotor activity, respiratory center, and vagus nerve.
The cosmetic composition of the present invention has excellent antioxidative and elasticity-improving effects, including a white-fly extract.
The above-mentioned extract can be obtained by extracting the flowers, medicines, fruits and the like with water or an organic solvent. Examples of the organic solvent include, but are not limited to, alcohols having 1 to 4 carbon atoms, acetone, chloroform, methylene chloride, ether, ethyl acetate, hexane and the like.
Examples of the extraction method include a method of mixing flowers, medicines, fruits, etc. with water or an organic solvent and extracting the mixture at a temperature of 80 to 150 ° C for 1 to 24 hours, followed by filtration, concentration and drying.
The solvent may be used in an amount of, for example, 2 to 10 times the weight of the flowers, medicines, fruits, etc., but is not limited thereto.
As another embodiment of the extraction method, extraction may be performed by applying ultrasonic waves at 20 to 60 DEG C for 1 to 5 hours.
The content ratio of each extract is not particularly limited and may be, for example, 2 to 10 wt% of calendula flower extract, 2 to 10 wt% of arnica flower extract, 0.005 to 0.5 wt% of drench extract, 0.005 to 0.5 wt% Preferably from 3 to 7% by weight of calendula flower extract, from 3 to 7% by weight of arnica flower extract, from 0.005 to 0.3% by weight of drench extract, from 0.005 to 0.3% by weight of Angelica gigantosa extract, And a white paper extract at a weight ratio of 0.005 to 0.3% by weight. When the mixing ratio is within the above range, it is possible to maximize the effects of moisturizing, improving atopic skin symptoms, and antioxidation.
If necessary, the cosmetic composition of the present invention can be applied to a cosmetic composition containing a compound selected from the group consisting of a screening oil extract, a mulberry extract, an octopus fennel extract, a lotus flower extract, a peony root extract, a golden extract, an amaranth extract, an okra fruit extract, And may further contain more than one kind of extract.
The cosmetic composition of the present invention may further comprise at least one extract selected from the group consisting of screenworm extract, mulberry extract, octopus fennel extract, lotus extract, peony root extract, golden extract, flax extract, okra fruit extract, burdock extract, It is possible to have more excellent antioxidation, atopic symptom improvement effect and the like.
The extract of at least one selected from the group consisting of screenworm extract, anthelmintic extract, octopus fennel extract, lotus extract, peony root extract, golden extract, flax extract, okra fruit extract, burdock extract, , Preferably 0.1 to 2% by weight, based on the total weight of the composition.
In addition, if necessary, it may further comprise one or more extracts selected from the group consisting of reed extract and grapefruit extract.
The cosmetic composition of the present invention further comprises at least one extract selected from the group consisting of a reed extract and a grapefruit extract, thereby reducing skin irritation.
A reed extract, and a grapefruit extract may be included in a total amount of 0 to 1% by weight, preferably 0.1 to 0.5% by weight, but is not limited thereto.
The cosmetic composition of the present invention may further contain other essential ingredients, if necessary, in combination with the cosmetic composition.
Examples of the components that can be blended include a preservative component, a moisturizer, an emollient, a surfactant, an organic and inorganic pigment, an organic powder, an ultraviolet absorber, an antiseptic, a bactericide, an antioxidant, a plant extract, a pH adjuster, , A cold agent, an antiperspirant agent, and purified water.
Examples of the fat-soluble ingredients include ester-based fats, hydrocarbon-based fats, silicon-based fats, fluorine-based fats, animal fats and plant fats and the like.
Examples of ester-based fats include glyceryl tri-2-ethylhexanoate, cetyl 2-ethylhexanoate, isopropyl myristate, butyl myristate, isopropyl palmitate, ethyl stearate, octyl palmitate, isocetyl isostearate, But are not limited to, ethylbutyl, butylbutyl, ethylbutylbutyl, butylbutyl, isobutylbutyl, isobutylbutyl, isobutylisobutyl, isobutylisobutyl, isobutylisobutyl, Trimethylol propane, triisostearic acid trimethylol propane, tetra-2-ethylhexanoic acid pentaerythritol tri (2-ethylhexanoic acid) Terephthalic acid, stearic acid, tallow, caprylic acid, decyl lauric acid, hexyl laurate, myristic acid myristate, myristyl myristate, myristyl acid stearyl, stearyl stearate, decyl oleate, cetyl ricinoleate, Octyldodecyl oleate, octyldodecyl oleate, octyldodecyl linoleate, isopropyl isostearate, isopropyl stearate, isostearyl stearate, isocetyl stearate, isodecyl oleate, isodecyl oleate, octyldodecyl oleate, Ethylhexanoate, stearylhexyl isostearate, stearyl 2-ethylhexanoate, hexyl isostearate, ethylene glycol dioctanoate, ethylene glycol dioleate, propylene glycol dicaprate, di (capryl, capric acid) propylene glycol, dicapryl Diethylene glycol monobutyl ether, diethylene glycol propylene glycol, dicapric acid neopentyl glycol, dioctanoic acid neopentyl glycol, tricarboxylic acid glyceryl, triunsaturated glyceryl, triisopalmitic acid glyceryl, triisostearic acid glyceryl, Octanoic acid octanoate, octanoic acid octanoate, octanoic acid octanoate, octanoic acid octanoate, octanoic acid octanoate, octanoic acid octanoate, octanoic acid octanoate, octanoic acid octanoate, octanoic acid octanoate, Octyldecyl lactate, octyldecyl stearate, polyglycerin oleic acid ester, polyglycerin isostearic acid ester, triisocetyl citrate, triisobutyl citrate, triisooctyl citrate, myristyl lactate, cetyl lactate, octyldecyl lactate, triethyl citrate , Acetyl triethyl citrate, acetyl tributyl citrate, trioctyl citrate, diisostearyl malate, 2-ethylhexyl hydroxystearate, di-2-ethylhexyl succinate, diisobutyl adipate, diisopropyl sebacate, Cholesteryl isostearate, chitostearic acid, cholestearyl isostearate, cholestearyl hydroxystearate, cholesteryl oleate, dihydrocholestearyl oleate, pitostearyl isostearate, pitostearyl oleate, 12 -Stearoylhydroxystearic acid isostearyl, 12-stearoylhydroxystearic stearyl, 12-stearoyl And esters such as hydroxystearic acid and sostearyl.
Hydrocarbon-based fats and oils such as squalene, liquid paraffin, alpha-olefin oligomer, isoparaffin, ceresin, paraffin, floating isoparaffin, polybutene, microcrystalline wax, and hydrogenated hydrocarbon such as vaseline.
Examples of silicone based oils include polymethyl silicone, methylphenyl silicone, methyl cyclopolysiloxane, octamethylpolysiloxane, decamethylpolysiloxane, dodecamethylcyclosiloxane, dimethylsiloxane-methylcetyloxysiloxane copolymer, dimethylsiloxane-methylstarchoxysiloxane copolymer, Alkyl-modified silicone oil, and amino-modified silicone oil.
Examples of the fluorine-based oil include perfluoropolyether and the like.
Examples of the animal or vegetable oil include avocado oil, almond oil, olive oil, sesame oil, rice bran oil, new flower oil, soybean oil, corn oil, rape oil, apricot kernel oil, palm kernel oil, palm oil, castor oil, sunflower oil, The present invention relates to a process for producing a starch-containing starch, which is selected from the group consisting of seed oil, cottonseed oil, palm oil, palm oil, cucumber nut oil, wheat germ oil, rice germ oil, Animal or vegetable fats such as oil, can-pick wax, carnauba wax, liquid lanolin, and hardened castor oil.
Examples of the moisturizing agent include water-soluble low-molecular moisturizing agents, oil-soluble molecular moisturizing agents, water-soluble polymers, and oil-soluble polymers.
Examples of the water-soluble low molecular weight moisturizing agent include serine, glutamine, sorbitol, mannitol, sodium pyrrolidone-carboxylate, glycerin, propylene glycol, 1,3-butylene glycol, ethylene glycol, polyethylene glycol B Propylene glycol (polymerization degree n = 2 or more), polyglycerin B (polymerization degree n = 2 or more), lactic acid, lactic acid salt and the like.
Examples of the lipid-soluble low-molecular moisturizing agent include cholesterol and cholesterol ester.
Examples of the water-soluble polymer include carboxyvinyl polymer, polyaspartic acid, tragacanth, xanthan gum, methylcellulose, hydroxymethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, carboxymethylcellulose, water-soluble chitin, chitosan, .
Examples of the oil-soluble polymer include a polyvinylpyrrolidone / eicosene copolymer, a polyvinylpyrrolidone / hexadecene copolymer, a nitrocellulose, a dextrin fatty acid ester, and a polymeric silicone.
The emollients include long chain acyl glutamic acid cholesteryl ester, hydroxystearic acid cholesteryl, 12-hydroxystearic acid, stearic acid, rosin acid, lanolin fatty acid cholesteryl ester, and the like.
Examples of the surfactant include a nonionic surfactant, an anionic surfactant, a cationic surfactant, and a positive surfactant.
Examples of nonionic surfactants include self emulsifying monostearic acid glycerin, propylene glycol fatty acid esters, glycerin fatty acid esters, polyglycerin fatty acid esters, sorbitan fatty acid esters, POE (polyoxyethylene) sorbitan fatty acid esters, POE sorbit fatty acid esters, POE-POP fatty acid ester, POE alkyl ether, POE fatty acid ester, POE hardened castor oil, POE castor oil, POE.POP (polyoxyethylene.polyoxypropylene) copolymer, POE.POP alkyl ether, polyether- Acid alkanolamides, alkylamine oxides, hydrogenated soybean phospholipids, and the like.
Examples of the anionic surfactant include fatty acid soap, alpha-acylsulfonate, alkylsulfonate, alkylarylsulfonate, alkylnaphthalenesulfonate, alkylsulfate, POE alkylether sulfate, alkylamide sulfate, alkyl phosphate, POE alkyl ginseng salt, alkyl Amide phosphate, alkyloyl taurine salt, N-acyl amino acid salt, POE alkyl ether carboxylate, alkylsulfosuccinate, sodium alkylsulfoacetate, acylated hydrolyzed collagen peptide salt, perfluoroalkyl phosphate ester and the like .
Examples of the cationic surfactant include alkyl trimethyl ammonium chloride, stearyl trimethyl ammonium chloride, stearyl trimethyl ammonium bromide, cetostearyl trimethyl ammonium chloride, distearyl dimethyl ammonium chloride, stearyl dimethyl benzyl ammonium chloride, behenyl trimethyl ammonium bromide, Benzalkonium chloride, diethylaminoethylamide stearate, dimethylaminopropylamide stearate, quaternary ammonium salts of lanolin derivatives, and the like.
Examples of amphoteric surfactants include carboxybetaine, amidebetaine, sulfobetaine, hydroxysulfobetaine, amidosulfobetaine, phosphobetaine, aminocarboxylate, imidazoline derivative, amideamine, etc. , And the like.
Examples of the organic and inorganic pigments include inorganic pigments such as silicic acid, silicic anhydride, magnesium silicate, talc, sericite, mica, kaolin, Bengala, clay, bentonite, titanium mica, titanium oxide, bismuth oxychloride, zirconium oxide, magnesium oxide, Inorganic pigments such as aluminum, calcium sulfate, barium sulfate, magnesium sulfate, calcium carbonate, magnesium carbonate, iron oxide, chromium oxide, chromium oxide, chromium oxide, But are not limited to, polyamide, polyester, polypropylene, polystyrene, polyurethane, vinyl resin, urea resin, phenol resin, fluororesin, silicon resin, acrylic resin, melamine resin, epoxy resin, polycarbonate resin, Silk powder, cellulose, CI Pigment Yellow, CI Pigment Orange, and composite pigments of inorganic pigments and organic pigments thereof.
Examples of the organic powder include metal soaps such as calcium stearate; Metal salts of alkyl phosphates such as sodium zinc cetylate, zinc laurylate and calcium lauryl laurate; Acylamino acid polyvalent metal salts such as N-lauroyl-beta-alanine calcium, N-lauroyl-beta-alanine zinc and N-lauroylglycine calcium; Amidosulfonic acid multivalent metal salts such as N-lauroyl-taurine calcium and N-palmitoyl-taurine calcium; Such as N-epsilon-lauroyl-L-lysine, N-epsilon-palmitoylidene, N-alpha-paratyylnitine, N-alpha-lauroyl arginine, Acyl basic amino acids; N-acylpolypeptides such as N-lauroylglycylglycine; Alpha-amino fatty acids such as alpha-aminocaprylic acid, alpha-aminoaurauric acid, and the like; Polyethylene, polypropylene, nylon, polymethylmethacrylate, polystyrene, divinylbenzene-styrene copolymer, ethylene tetrafluoride, and the like.
Examples of the ultraviolet absorbing agent include pamoaminobenzoic acid, ethyl p-aminobenzoate, amyl p-aminobenzoate, octyl p-aminobenzoate, ethylene glycol salicylate, phenyl salicinate, benzyl salicylate, benzyl salicylate, butylphenyl salicylate, homomenthyl salicylate, Benzyl, 2-ethoxyethyl methoxycinnamate, octyl methoxycinnamate, mono-2-ethylhexane glyceryl dipyrromethoxycinnamate, isopropyl methoxycinnamate, diisopropyl-diisopropyl cinnamate ester mixture, Dihydroxymethoxybenzophenone sulfonic acid, dihydroxybenzophenone sulfonic acid, dihydroxybenzophenone sulfonic acid and its salt, dihydroxymethoxybenzophenone, sodium dihydroxymethoxybenzophenone disulfonate, dihydroxybenzo Phenanone, tetrahydroxybenzophenone, 4-tert-butyl-4'-methoxydibenzoylmethane, 2,4,6-trianylino-p- (carbo-2'-ethylhexyl- 1,3,5-triazine, 2- (2-hydroxy -5-methylphenyl) benzotriazole, and the like.
Examples of the bactericide include hinokitiol, trichloroacetic acid, trichlorohydroxydiphenyl ether, crohexidine gluconate, phenoxyethanol, resorcin, isopropylmethylphenol, azulene, salicylic acid, No. 301, mononitro and eicoll sodium, undecylenic acid, and the like.
Examples of the antioxidant include butylhydroxyanisole, gallic acid propyl, and eicosorbic acid.
Examples of the pH adjusting agent include citric acid, sodium citrate, malic acid, sodium malate, fumaric acid, sodium fumarate, succinic acid, sodium succinate, sodium hydroxide, sodium monohydrogenphosphate and the like.
Examples of the alcohol include higher alcohols such as cetyl alcohol.
Any of the above components may be blended to the extent that the object and effect of the present invention are not impaired, but it is preferably 0.01 to 5% by weight based on the total weight, Preferably 0.01 to 3% by weight.
The cosmetic composition of the present invention may take the form of a solution, an emulsion, a viscous mixture or the like.
The ingredients contained in the cosmetic composition of the present invention may contain, as an active ingredient, the ingredients commonly used in cosmetic compositions in addition to the above-mentioned pharmacologic extracts. Examples of such ingredients include conventional ones such as stabilizers, solubilizers, vitamins, Adjuvants and carriers.
The cosmetic composition produced by the method of the present invention may have conventional formulations and may be in the form of, for example, a skin, lotion, essence, lotion, nutritional cream, massage cream, moisture cream, hand cream, , Body oil, body essence, and the like. The composition of each of these formulations may contain various kinds of bases and additives necessary for formulation of the formulation, and the kinds and amounts of these ingredients can be easily selected by those skilled in the art.
BEST MODE FOR CARRYING OUT THE INVENTION Hereinafter, the present invention will be described in detail with reference to examples.
Example
The extracts were prepared according to the composition and content (% by weight) shown in Table 1 below, and the obtained extracts and the ingredients shown in the lower part of Table 1 were mixed to prepare a moisturizing cream.
The extracts were obtained by adding 10 times water to the weight of the composition shown in Table 1 below, and ultrasonically applying ultrasonic waves to the ultrasolificator (JAC 4020, Jinwoo, Korea) for 3 hours at 35 ° C and lyophilizing the extract.
b-1
0.01
b-2
0.01
b-1
0.01
b-1
0.01
b-1
0.01
b-1
0.01
b-1
0.01
b-1
0.01
b-1
0.01
b-1
0.01
b-1
0.01
b-1 /
c-1
0.01 /
10
a-2: Golden
a-3: Okra fruit
b-1: Reed
b-2: Grapefruit
c-1:
2% by weight of lipophilic monostearic acid glycerin
2% by weight of stearyl alcohol
Stearic acid 1.3 wt%
Polysorbate 60 1.3 wt%
Sorbitan stearate 0.9 wt%
4.3% by weight mineral oil
1.5% by weight of hydrogenated vegetable oil
Wax 0.5 wt%
Squalane 2.5 wt%
4.3% by weight trioctanoin
Dimethicone 1.5 wt%
0.2% by weight sodium magnesium silicate < RTI ID = 0.0 >
Glycerin 4.3 wt%
Betaine 3.5 wt%
1% by weight triethanolamine
Sodium hyaruronate 3 wt%
Distilled water balance
Experimental Example
1. Assessment of cytotoxicity
The extracts of Examples and Comparative Examples were treated with B16F10 melanoma cells and the viability of the cells was measured using an MTT assay.
The cultured cells were treated with 0.1 mg / ml of the extracts of Examples and Comparative Examples, respectively, and cultured in a cell culture incubator at 37 ° C for 3 days under a 5% CO 2 environment.
Then, the cells were washed once with phosphate buffered saline (PBS), treated with 0.5 μg / ml of MTT reagent, and incubated for 30 minutes in an incubator under the same conditions.
Then, formazan crystals produced by treating DMSO (dimethyl sulfoxide) were dissolved in each well and the absorbance was measured.
The cytotoxicity measurement results are shown in Fig. 1 as a percentage of the absorbance of the sample in the control (0 mg / ml of 90% methanol extract of red ginseng). Cells not treated with the extract were used as positive control.
2. Antioxidant activity evaluation
Antioxidant activity was evaluated by confirming free radical scavenging activity by 1,1-diphenyl-2-picryl-hydrazyl (DPPH) method.
0.1 mM of DPPH solution diluted with 4 ml of ethanol and 100 mg / ml of the extract of Examples and Comparative Examples were mixed and allowed to stand at room temperature for 30 minutes. Thereafter, the absorbance was measured at 517 nm, and the results are shown in Fig. Ascorbic acid was used as a positive control.
3. Atopic skin improvement symptom evaluation
NC / Nga mouse (male, 9 weeks old, 60 rats) was used as the subject animal. The mice were stabilized for one week, and hair, neck, and back were removed, and 100 mg of Dermatophagoides pteronyssinus crude extract (DPE) was uniformly applied to the hair removal area.
DPE was applied 3 times a week for 3 weeks. After 1 time, 4% SDS solution was applied with a brush instead of hair removal cream.
The application of the cosmetic composition was started at the time when the three weeks of induction period of atopic dermatitis was completed, and was applied to the atopic dermatitis induced area for 14 days with a brush every afternoon.
After 14 days of application of the cosmetic composition, mice were orbitalized and serum was separated. Serum IgE was measured by Mouse IgE ELISA assay kit (XpressBio Life Science Products, Catalog No. 595-700, Express Biotech International, Thurmont, USA) And the absorbance at 450 nm was measured. The results are shown in Fig.
The experimental group was divided into the normal group (n = 4), the application group (n = 52, n = 4 in each example and comparative example) and the control group (n = 4).
4. Skin Moisture Evaluation
The percent humidities (%) of the dorsal skin of the mice in each group were measured with a corneometer CM820 (Courage & Khazaka, Cologne, Germany) and a tewameter TM210 (Courage & Khazaka, Cologne, Germany).
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Cited By (2)
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| US20190290575A1 (en) | 2018-03-23 | 2019-09-26 | Mary Kay Inc. | Topical compositions and methods |
| KR20200029739A (en) * | 2018-09-11 | 2020-03-19 | 주식회사 코리아나화장품 | Cosmetic composition comprising extract of calendula arvensis fermented by aureobasidium pullulans |
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| KR20210135034A (en) | 2020-05-04 | 2021-11-12 | 주식회사 엘라플로스 | Composition for improving skin barrier comprising herb extracts mixture |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004168705A (en) * | 2002-11-20 | 2004-06-17 | Pola Chem Ind Inc | Preparation for external use for ameliorating skin condition |
| KR101183893B1 (en) * | 2009-12-30 | 2012-09-19 | (주)휴벨 | Cosmetic composition having improving ability for atopy dermatitis and method for using the same |
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2016
- 2016-01-29 KR KR1020160011687A patent/KR101810409B1/en active IP Right Grant
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20190290575A1 (en) | 2018-03-23 | 2019-09-26 | Mary Kay Inc. | Topical compositions and methods |
| US11701322B2 (en) | 2018-03-23 | 2023-07-18 | Mary Kay Inc. | Topical compositions and methods |
| KR20200029739A (en) * | 2018-09-11 | 2020-03-19 | 주식회사 코리아나화장품 | Cosmetic composition comprising extract of calendula arvensis fermented by aureobasidium pullulans |
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| Publication number | Publication date |
|---|---|
| KR101810409B1 (en) | 2017-12-19 |
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