KR20160111693A - strip for inspecting reaction, inspection apparatus of strip - Google Patents

strip for inspecting reaction, inspection apparatus of strip Download PDF

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KR20160111693A
KR20160111693A KR1020150036679A KR20150036679A KR20160111693A KR 20160111693 A KR20160111693 A KR 20160111693A KR 1020150036679 A KR1020150036679 A KR 1020150036679A KR 20150036679 A KR20150036679 A KR 20150036679A KR 20160111693 A KR20160111693 A KR 20160111693A
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reaction
strip
pattern
inspection
position information
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KR1020150036679A
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Korean (ko)
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최규진
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서울바이오시스 주식회사
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Publication of KR20160111693A publication Critical patent/KR20160111693A/en

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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17Systems in which incident light is modified in accordance with the properties of the material investigated
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483Physical analysis of biological material
    • G01N33/487Physical analysis of biological material of liquid biological material
    • G01N33/493Physical analysis of biological material of liquid biological material urine
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54306Solid-phase reaction mechanisms
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00029Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1009Characterised by arrangements for controlling the aspiration or dispense of liquids
    • G01N35/1011Control of the position or alignment of the transfer device
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06KGRAPHICAL DATA READING; PRESENTATION OF DATA; RECORD CARRIERS; HANDLING RECORD CARRIERS
    • G06K7/00Methods or arrangements for sensing record carriers, e.g. for reading patterns
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00Image analysis
    • G06T7/0002Inspection of images, e.g. flaw detection

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  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
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  • General Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
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  • Urology & Nephrology (AREA)
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  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)

Abstract

The present invention relates to a strip for inspecting a reaction and a reaction inspecting device using the same. According to an embodiment of the present invention, the strip for inspecting the reaction comprises: a body part having certain width, height, and length; a plurality of reaction inspecting parts arranged along a longitudinal direction of the body part on one side of the body part and offering an outcome of the reaction with a target molecule in a form of color information; and a position information indicator disposed inside or on a surface of the body part corresponding to the position of the reaction inspecting parts and offering position information of the reaction inspecting parts to a position reading device. The position information indicator includes at least one of an optical signal pattern, a physical structure pattern, an electric circuit pattern, and an image pattern.

Description

[0001] The present invention relates to a strip for inspecting reaction,

Disclosure of the Invention The present disclosure relates to a reaction test strip and a reaction test apparatus using the same.

The term "reaction strip" refers to a kind of test paper used to determine the result of a predetermined chemical reaction. As an example, when a urine test is performed to detect a target antigen in the urine, the test strip may include a reagent comprising an antibody that reacts with the antigen. In addition, the reaction test strip can also easily identify whether the test person has a predetermined target antigen in the urine by expressing the result of the antigen-antibody reaction as a color change.

Brief Description of the Drawings Fig. 1 is a view schematically showing a conventional reaction test strip. Fig. 1 (a), the reaction test strip 10 includes a plurality of reaction sites 110, 120, 130, 140, and 150 having different antibody reagents on the body 105 . Thus, as shown in FIG. 1 (b), the color change observation of the plurality of reaction sites 110, 120, 130, 140, and 150 is performed only once by immersing in the container 170 containing the urine 160 The results of multiple antigen-antibody reactions can be confirmed.

In the case of the above-described conventional test strips, the test results can be easily confirmed even by the general public who does not have expert knowledge, by confirming the result of the antigen-antibody reaction through the color change of the reaction site. However, in the inspection industry, in which a large number of test strips are used to check the test results, the above-described method may be subject to various limitations. First, depending on the case, the color indicating the result of the antigen-antibody reaction may vary with time. That is, the antigen-antibody reaction may be contaminated or influenced by the surrounding environment over time and may exhibit undesirable color changes. Secondly, it is therefore necessary to observe the hue of the result of the antigen-antibody reaction within a limited time, which may be difficult to ascertain through manual inspection by the inspector.

The embodiment of the present disclosure provides a reaction inspection strip and an inspection apparatus therefor that can efficiently confirm a predetermined reaction inspection result within a limited time.

Disclosed is a reaction test strip according to one aspect of the present disclosure. The reaction test strip includes a body portion having a predetermined width, height, and length, a plurality of reaction portions arranged along a longitudinal direction of the body portion on one surface of the body portion, And a positional information marker disposed on a surface or inside of the body corresponding to the position of the reaction inspection part and providing position information of the reaction inspection part to the position reading device. The position information markers include at least one of an optical signal pattern, a physical structure pattern, an electric circuit pattern, and an image pattern.

A reaction test apparatus according to another aspect of the present disclosure is disclosed. Wherein the reaction test apparatus comprises a reaction test strip having a reaction test section and a positional information marker disposed at a position corresponding to a position of the reaction test section, a reaction test strip disposed adjacent to the reaction test strip, A position reading device for detecting the position information markers of the reaction test strip when moving in one direction, and a photographing device for photographing the reaction inspection part in synchronization with the timing at which the position reading device detects the position information markers . The position information markers include at least one of an optical signal pattern, a physical structure pattern, an electric circuit pattern, and an image pattern.

According to the present disclosure, the reaction test strip may include a positional information marker that provides positional information of a reaction inspection unit that provides the reaction result with the target material as color information. The image of the reaction inspection part can be easily photographed while moving the reaction inspection strip using the information of the position information markers.

Particularly, in the case of moving the reaction test strip through manual operation, the reaction test strip can be passed through the inspection apparatus with constant velocity or acceleration. In this way, even when the reaction inspection strip moves at a constant speed or acceleration, the image of the reaction inspection part can be acquired quickly by driving the photographing device in synchronization with the position information of the position information markers. The obtained image can be effectively provided to read whether or not the reaction result is within a limited time.

Brief Description of the Drawings Fig. 1 is a view schematically showing a conventional reaction test strip. Fig.
2A schematically shows a reaction test strip according to a first embodiment of the present disclosure;
FIG. 2B is a view schematically showing a method of using the reaction test strip of FIG. 2A. FIG.
3A is a schematic view of a reaction test strip according to a second embodiment of the present disclosure;
FIG. 3B is a view schematically showing a method of using the reaction test strip of FIG. 3A.
Fig. 3c is a schematic view showing another method of using the reaction test strip of Fig. 3a.
4 is a schematic view of a reaction test strip according to a third embodiment of the present disclosure;
Fig. 5 is a view schematically showing a reaction inspection strip according to a fourth embodiment of the present disclosure; Fig.
6A is a view schematically showing a reaction inspection strip according to the sixth embodiment of the present disclosure.
FIG. 6B is a view schematically showing a method of using the reaction test strip of FIG. 6A.
7 is a view schematically showing a reaction inspection strip according to a seventh embodiment of the present disclosure.
8 is a view schematically showing a reaction inspection strip according to an eighth embodiment of the present disclosure.
9A is a view schematically showing a reaction inspection strip according to a ninth embodiment of the present disclosure.
Figs. 9B and 9C are schematic views showing cross sections of portions A and B in the reaction test strip of Fig. 9A. Fig.
FIG. 9D is a view schematically showing a method of using the reaction test strip of FIG. 9A.
10 is a cross-sectional view schematically showing a reaction test strip according to a tenth embodiment of the present disclosure.
11 is a cross-sectional view schematically showing a strip for reaction inspection according to an eleventh embodiment of the present disclosure.
12 is a schematic representation of a reaction test apparatus using a reaction test strip according to one embodiment of the present disclosure;
Figure 13 is a schematic representation of a reaction test apparatus using a reaction test strip according to another embodiment of the present disclosure;

Embodiments of the present disclosure will now be described in more detail with reference to the accompanying drawings. However, the techniques disclosed in this disclosure are not limited to the embodiments described herein but may be embodied in other forms. In the drawings, the width, thickness, and the like of the components are enlarged in order to clearly illustrate the components of each device.

Where an element is referred to herein as being located on another element "above" or "below", it is to be understood that the element is directly on the other element "above" or "below" It means that it can be intervened. In this specification, the terms 'upper' and 'lower' are relative concepts set at the observer's viewpoint. When the viewer's viewpoint is changed, 'upper' may mean 'lower', and 'lower' It may mean.

Like numbers refer to like elements throughout the several views. It is to be understood that the singular forms "a", "an", and "the" include plural referents unless the context clearly dictates otherwise, and the terms "comprise" Or combinations thereof, and does not preclude the presence or addition of one or more other features, integers, steps, operations, elements, components, or combinations thereof.

2A schematically shows a reaction test strip according to a first embodiment of the present disclosure; FIG. 2B is a view schematically showing a method of using the reaction test strip of FIG. 2A. FIG.

2A, the reaction test strip 20 includes a body 210, a plurality of reaction inspectors 220a, 220b, ..., 220l, and position information markers 232a, 232b, ..., 232l, 234a, 234b , ..., 234l.

The body 210 constitutes the outer appearance of the reaction test strip 20 and may have a predetermined width w, height h and length l. The body portion 210 may be made of a flexible material, for example.

The plurality of reaction inspecting units 220a, 220b, ..., and 220l may be arranged along the length 1 direction of the body portion 210 on one side of the body portion 210. [ Each of the reaction inspection units 220a, 220b, ..., and 220l may include reagents that react with different target materials. The reaction inspecting units 220a, 220b,..., And 220l may receive the target solution provided from the outside and provide the result of the reaction with the target material in the target solution as color information. As an example, the target solution may be urine, and each reaction inspecting unit 220a, 220b, ..., 220l may display an antigen-antibody reaction result with different target antigens as a color change.

The position information markers 232a, 232b, ..., 232l, 234a, 234b, ..., and 234l may be disposed on or in the surface of the body 210 corresponding to the positions of the reaction inspectors 220a, 220b, have. The position information markers 232a, 232b, ... 232l, 234a, 234b, ..., and 234l are read by the position reading device 250 shown in Figure 2b, Information can be provided.

As shown in FIG. 2A, the position information markers 232a, 232b, ..., 232l, 234a, 234b, ..., and 234l are arranged on the surface of the body portion 210 so that the positions of the reaction inspectors 220a, 220b, ..., And may be an optical signal pattern disposed apart from both side directions. As a specific example, the optical signal pattern may be a bar code disposed on the surface of the body 210 to correspond to positions of the plurality of reaction inspection units 220a, 220b, ..., and 220l.

Referring to FIG. 2B, the reaction inspection strip 20 can be manipulated to move in the M1 direction on the strip concentrator 240. FIG. As an example, the above operation may be performed by hand or by a conveying device. The information provided by the position information markers 232a, 232b, ..., 232l, 234a, 234b, ..., 234l can be read by the position reading device 250 when the reaction inspection strip 20 moves. As shown, the location reading device 250 may be a reader having sensors 252a, 252b capable of reading bar codes. The sensors 252a and 252b detect the position information indicia 232a, 232b, ..., 232l, 234a, 234b, ..., 234l ), It is possible to read the position information of the reaction inspection units 220a, 220b, ..., 220l.

In a more specific embodiment, the reaction checking units 220a, 220b, ..., and 220l may be disposed at positions adjacent to the position where the position reading apparatus 250 reads the bar code by a predetermined distance. Accordingly, the position reading apparatus 250 can discontinuously transmit the image photographing signal to the photographing apparatus, which will be described later, every time the bar code of the reaction inspection strip 20 is recognized. The photographing apparatus can receive the image photographing signal and photograph images of the corresponding reaction inspecting units 220a, 220b, ..., and 220l, respectively.

3A is a schematic view of a reaction test strip according to a second embodiment of the present disclosure; FIG. 3B is a view schematically showing a method of using the reaction test strip of FIG. 3A. Fig. 3c is a schematic view showing another method of using the reaction test strip of Fig. 3a.

3A, the reaction test strip 30 includes position information markers 330a, 330b, ..., and 330l disposed in the body 210, as compared with the reaction test strip 20 of the first embodiment, Is differentiated. Hereinafter, in order to exclude duplication, differentiated configurations will be mainly described.

In this embodiment, the location information markers 330a, 330b, ..., 330l may be a physical structure pattern. Specifically, the physical structure pattern may include a protruding structure or a concave structure disposed on a side surface of the body 210 so as to correspond to positions of the plurality of reaction inspection units 220a, 220b, ..., 220l. Referring to FIG. 3A, as the position information markers 330a, 330b,..., 330l, sawtooth structures may be regularly arranged on one side of the body portion 210. FIG. As an example, the serrated structures may be arranged to correspond one to one to the respective reaction inspection sections 220a, 220b, ..., 220l.

Referring to FIG. 3B, the reaction test strip 30 may be manipulated to move in the direction of M1 on the strip concentrator 240. FIG. As an example, the above operation may be performed by hand or by a conveying device. When the reaction inspection strip 30 moves, information provided by the position information markers 330a, 330b, ..., and 330l can be read by the position reading device 350. [

The position reading apparatus 350 may include an image photographing apparatus and may be fixed to the strip converging apparatus 240. When the reaction inspection strip 30 moves at constant speed or acceleration to the strip converging device 240, the position reading device 350 reads the serrated image so that the reaction inspection portions 220a, 220b, ..., 220l ) Can be confirmed. In a more specific embodiment, the reaction inspectors 220a, 220b, ..., and 220l may be disposed at positions adjacent to the serrated structure by a predetermined distance. Thus, each time the position reading apparatus 350 reads the serrated image of the reaction inspection strip 30, it is possible to discontinuously transmit the image photographing signal to the photographing apparatus described later. The photographing apparatus can receive the image photographing signal and photograph images of the corresponding reaction inspecting units 220a, 220b, ..., and 220l, respectively.

3C, the position reading device 360 may include a light source 362 and a light detector 364, and the position reading device 360 may be fixed to the strip converging device 240.

The light source 362 may irradiate light of a predetermined wavelength, and the photodetector 364 may collect the irradiated light. When the reaction test strip 30 moves at equal speed or acceleration on the strip converging device 240, the light source 362 continuously irradiates light to the same area in a fixed state. During the movement of the reaction test strip 30, when the irradiated light is intercepted by the serrated structure of the position information markers 330a, 330b, ..., and 330l, the light does not reach the photodetector 364 . When light does not reach the photodetector 364, it can be determined that the reaction inspection units 220a, 220b, ..., and 220l are present at adjacent positions. Conversely, light may reach the photodetector 364 if the irradiated light is not blocked by the serrated structure. As described above, when the photodetector 364 can not receive light during the movement of the reaction inspection strip 30, the position reading device 360 can discontinuously transmit the image pickup signal to the image pickup apparatus described later . The photographing apparatus can receive the image photographing signal and photograph images of the corresponding reaction inspecting units 220a, 220b, ..., and 220l, respectively.

4 is a schematic view of a reaction test strip according to a third embodiment of the present disclosure; In a third embodiment, the location information markers 332a, 332b, 332c may include a serrated structure.

4, in the reaction test strip 32, the position information markers 332a, 332b, and 332c may not correspond one to one to the reaction inspectors 220a, 220b, ..., and 220l. One location information indicator 332a, 332b, and 332c may correspond to a predetermined plurality of reaction inspection units 220a, 220b, ..., and 220l.

In one embodiment, the location information indicator 332a may cover the four reaction checkers 220a, 220b, 220c, and 220d. Likewise, the position information indicators 332b and 332c may cover four reaction inspection sections, respectively.

When the position reading device 360 determines the position information indicator 332a and transmits a photographing signal to the photographing apparatus, the photographing apparatus receives the photographing signal and transmits the four reaction checking units 220a, 220b, 220c and 220d You can shoot at the same time. Even when the position reading device 360 judges the position information markers 332b and 332c, the photographing device can simultaneously photograph four reaction inspection parts according to the photographing signal.

Fig. 5 is a view schematically showing a reaction inspection strip according to a fourth embodiment of the present disclosure; Fig. In the fourth embodiment, the position information markers 333a, 333b, ..., 333l, 334a, 334b, ..., and 334l may include a serrated structure.

5, the position information markers 333a, 333b, ..., 333l, 334a, 334b, ..., and 334l may be formed on both sides of the body portion 210 at the same time in the reaction test strip 34 . This makes it possible to enhance the reliability of the positional information indicated by the positional information markers 333a, 333b, ..., 333l, 334a, 334b, ..., 334l. The position information markers 333a, 333b, ..., and 333l arranged on one side may have different shapes from the position information markers 334a, 334b, ..., and 334l arranged on the other side. However, the position information markers located on the same side may have the same shape.

6A is a view schematically showing a reaction inspection strip according to the sixth embodiment of the present disclosure. FIG. 6B is a view schematically showing a method of using the reaction test strip of FIG. 6A. In this embodiment, the reaction test strip 40 may include a physical structure pattern as a position information marker. The physical structure pattern may include a step pattern formed along the longitudinal direction of the body portion 210.

Referring to FIG. 6A, the reaction test strip 40 may have a plurality of segments 41, 42, 43, 44 having different widths and lengths. Specifically, the first segment 41 has a first width w1 and a first length l1, and the first reaction part 220a, 220b, 220c, 220d on the first body part 410 . The first segment 41 may include a first switch 41s. The first switch 41s may have a sectional structure composed of the first width w1 and the height h in the first segment 41. [

The second segment 42 may have a second width w2 and a second length 12 and may include second reaction inspection portions 220e, 220f, 220g, and 220h on the second body portion 412 have. And the second segment 42 may include the second switch 42s. The second switch 42s may be a stepped pattern composed of the difference between the second width w2 and the first width w1 and the height h in the second segment 42. [

The third segment 43 may have a third width w3 and a third length 13 and may include a third reaction inspector 220i, 220j, 220k, 220l on the third body 414 have. The third switch 43s may be a stepped pattern composed of the difference between the third width w3 and the second width w2 and the height h in the third segment 43. [

The fourth segment 44 may have a fourth width w3 and a fourth length 14 and may not have a reaction checker on the fourth body 416. [ The fourth switch 44s may be a stepped pattern composed of the difference between the fourth width w4 and the third width w3 and the height h in the fourth segment 44. [

Referring to FIG. 6B, the reaction test strip 40 may be operated to move at equal velocity or acceleration in the M2 direction on the strip concentrator 440. [0051] FIG. As an example, the above operation may be performed by hand or by a conveying device. The strip concentrator 440 includes a first button 41t in contact with the first switch 41s, a second button 42t in contact with the second switch 42s, a third button 42t in contact with the third switch 43s, A button 43t, and a fourth button 44t in contact with the fourth switch 44s. The first to fourth buttons 41t 42t 43t 44t may be disposed on the first to fourth rails 442 444 446 448 formed on one side of the strip concentrator 440 have. The first to fourth buttons 41t, 42t, 43t, and 44t may be, for example, electronic or mechanical buttons.

After the first switch 41s of the first segment 41 first contacts the first button 41t when the strip concentrator 440 moves in the direction M2, 442). ≪ / RTI > When the first button 41t and the first switch 41s are in contact with each other, a first photographing signal can be transmitted from the strip converging device 440 to the photographing apparatus. The second segment 42 can then move on the first and second rails 442 and 444 after the second switch 42s of the second segment 42 first contacts the second button 42t have. When the second button 42t and the second switch 42s are in contact with each other, a second photographing signal can be transmitted from the strip converging device 440 to the photographing apparatus. Next, after the third switch 43s of the third segment 43 first contacts the third button 43t, the third segment 43 is moved on the first to third rails 442, 444, 446 Can be moved. When the third button 43t and the third switch 43s are in contact with each other, a third photographing signal can be transmitted from the strip converging device 440 to the photographing apparatus. Then, after the fourth switch 44s of the fourth segment 44 first contacts the fourth button 44t, the fourth segment 44 is moved to the first to fourth rails 442, 444, 446, 448, The image can be moved. When the fourth button 44t and the fourth switch 44s are in contact with each other, a photographing completion signal can be transmitted from the strip converging device 440 to the photographing apparatus. According to the first to third shooting signals, four reaction test sections can be photographed simultaneously. In this manner, the strip concentrator 440 including the first to fourth buttons 41t, 42t, 43t, and 44t can perform the function of the position reading apparatus as well.

7 is a view schematically showing a reaction inspection strip according to a seventh embodiment of the present disclosure. Referring to FIG. 7, the reaction strip 42 may have a plurality of segments 41, 42, 43, 44 having different widths and lengths. At this time, one reaction inspecting unit 420a, 420b, and 420c may be disposed on each of the segments. Accordingly, one reaction inspection section can be photographed in accordance with one photographing signal.

8 is a view schematically showing a reaction inspection strip according to an eighth embodiment of the present disclosure. Referring to FIG. 8, the reaction strip 44 may include a plurality of segments 51, 52, 53, and 54 having different widths and lengths. In the figure, the first to fourth switches 51s, 52s, 53s, and 54s may be disposed on the end faces of the plurality of segments 51, 52, 53,

Comparing the second to fourth switches 52s, 53s and 54s of this embodiment with the second to fourth switches 42s, 43s and 44s of the sixth and seventh embodiments, the switches of the sixth and seventh embodiments 43s, 44s are disposed on both sides of the section of the segments 42, 43, 44, respectively. On the other hand, the second to fourth switches 52s, 53s, and 54s of the present embodiment may be disposed on one side of each of the segments 52, 53, and 54, respectively.

9A is a view schematically showing a reaction inspection strip according to a ninth embodiment of the present disclosure. Figs. 9B and 9C are schematic views showing cross sections of portions A and B in the reaction test strip of Fig. 9A. Fig. FIG. 9D is a view schematically showing a method of using the reaction test strip of FIG. 9A.

9A to 9C, the reaction test strip 50 may be provided with an electric circuit pattern as a positional information marker. The electric circuit pattern may be a resistance pattern disposed in a lower body 210 of the plurality of reaction inspectors 220a, 220b, ..., 220l. Referring to FIGS. 9B and 9C, resistance patterns 535g and 535h are disposed in the body 210 under the reaction inspectors 220h and 220g, respectively. In addition, first pads 530g and 530h electrically connected to the resistance patterns 535g and 535h may be disposed on the sidewalls of the body 210, respectively. The resistance value of the one resistance pattern 535g and the resistance value of the other resistance pattern 535h may be equal to or different from each other.

Referring to FIG. 9D, the reaction test strip 50 may be operated to move at equal speed or acceleration in the direction of M1 on the strip convergence apparatus 540. FIG. As an example, the above operation may be performed by hand or by a conveying device.

The position reading device 550 may include a fixing portion 550a and a sensing portion 550b. The fixing unit 550a may serve to fix the sensing unit 550b to the strip converging unit 540. [ The sensing unit 550b may include a pair of second pads (not shown) arranged to contact the first pads of the reaction test strip 50 at corresponding positions. A predetermined voltage may be applied between the pair of second pads.

The first pad disposed discontinuously on the body portion 210 and the second pad of the position reading device 550 are brought into contact and contact with each other when the reaction test strip 50 moves on the strip concentrator 540. [ Detachment can be repeated. When the first pad and the second pad are in contact with each other, the electric resistance of the electric circuit pattern may be reduced. The position reading apparatus 550 can transmit an image photographing signal to the photographing apparatus when this resistance decrease signal is read.

10 is a cross-sectional view schematically showing a reaction test strip according to a tenth embodiment of the present disclosure. Referring to FIG. 10, the reaction test strip 60 has a constitutional difference with respect to the arrangement of the first pads when compared with the reaction test strip 50 of the ninth embodiment. The resistance patterns 635g under the reaction inspecting section 220h are disposed and the first pads 631g, 632g, and 633g may be disposed on both side walls and bottom surfaces of the body section 210, respectively. The resistance pattern 635g may be an electric circuit connecting the first pads 631g, 632g, and 633g, which are different from each other.

The position reading apparatus includes a pair of second pads (not shown) to which predetermined voltages are applied at positions corresponding to the first pads 631g, 632g, and 633g, so that the first and second pads , The electrical resistance reduction of the electric circuit pattern can be read.

11 is a cross-sectional view schematically showing a strip for reaction inspection according to an eleventh embodiment of the present disclosure. Referring to Fig. 11, the reaction test strip 70 has a constitutional difference in relation to the arrangement of the first pads when compared with the reaction test strip 50 of the ninth embodiment.

In this embodiment, a plurality of first pads corresponding to one reaction inspection part may be disposed on the side wall of the body part 210. [ The resistance pattern constituting the electric circuit pattern can connect two pads selected from a plurality of first pads disposed on both side walls of the body portion 210 to each other. In one specific example, the resistance pattern 735h under the one reaction inspecting section 220h is formed by connecting two first pads 730h1 and 730h2 disposed on opposite side walls among a plurality of first pads disposed on both side walls . In another example, the resistance pattern 735g under the one reaction inspecting portion 220g includes two first pads 730g2 and 730g3 disposed adjacent to the same side wall among a plurality of first pads disposed on both side walls, You can connect.

The position reading apparatus may have the same number of second pads as the number of the first pads corresponding to one reaction inspection unit. Thus, when the first pad and the second pad are in contact, the electrical resistance reduction in the other resistance pattern can be read.

12 is a schematic representation of a reaction test apparatus using a reaction test strip according to one embodiment of the present disclosure; Referring to FIG. 12, the reaction inspection apparatus 1200 includes a reaction inspection strip 20, a position reading apparatus 250, and a photographing apparatus 260.

The reaction test strip 20 includes positional information markers 232a, 232b, ..., 220l disposed at positions corresponding to positions of the reaction inspectors 220a, 220b, ..., 220l and reaction inspectors 220a, 220b, ..., 220l. , 232l, 234a, 234b, ..., 234l. The configuration of the reaction test strip 20 is the same as that of the reaction test strip 20 according to the second embodiment of FIG. 2A.

The position reading device 250 is disposed adjacent to the reaction inspection strip 20 and detects the position information markers on the reaction inspection strip 20 when the reaction inspection strip 20 moves in one direction at a constant speed or acceleration 232a, 232b, ..., 232l, 234a, 234b, ..., 234l. The configuration of the position reading apparatus 250 is the same as that of the position reading apparatus 250 according to the second embodiment of FIG. 2B.

In some other embodiments, as the reaction test strip, the reaction test strips described above with reference to Figs. 3A, 4, 5, 6A, 7, 8, 9A, 10, (30, 32, 34, 40, 42, 44, 50, 60, 70) may be applied. Correspondingly, as the position reading apparatus, the position reading apparatuses 250, 350, 360, 440 and 550 described above with reference to Figs. 2B, 3B, 3C, 6B and 9D can be applied.

Referring again to FIG. 12, the photographing apparatus 260 may be disposed adjacent to the strip converging apparatus 240. The photographing apparatus 260 is configured to detect the positions of the reaction inspection units 220a, 220b, ..., 234l in synchronization with the timing at which the position reading apparatus 250 detects the position information markers 232a, 232b, ..., 232l, 234a, 234b, 220l.

The photographing apparatus 260 may include a light source 262 and a photodetector 264. The light source 262 may provide visible light or ultraviolet light to the strip converging device 240 to enable color discrimination of the reaction testing strip 20 moving on the strip converging device 242. [

The photodetector 264 may be disposed adjacent to the light source 262 and may include a color sensor. The photodetector 264 can acquire information necessary for implementing the images of the reaction inspection units 220a, 220b, ..., and 220l.

In some embodiments, the light source 262 may comprise a first polarizing filter polarized in a first direction and the photodetector 264 may comprise a second polarizing filter polarized in a direction perpendicular to the first direction . Thus, the light source 262 provides the light polarized in the first direction to the reaction inspecting units 220a, 220b, ..., and 220l, and the light detector 264 emits the light beams emitted from the reaction inspecting units 220a, 220b, ..., It is possible to collect the light polarized in the second direction out of the light.

The light polarized in the first direction may be scattered on the surfaces of the reaction inspectors 220a, 220b, ..., 220l after entering the reaction inspectors 220a, 220b, ..., 220l. At this time, the scattered light can be the light polarized in the first direction and can generate the gloss of the reaction inspection units 220a, 220b, ..., 220l. Generally, the gloss can act as an element that hinders the clear color determination of the reaction inspection sections 220a, 220b, ..., 220l. Therefore, the photodetector 264 can capture the clear color by suppressing the light that is polarized in the first direction, which is the incident light, and collecting the light polarized in the second direction.

In some embodiments, the polarization states of the light incident on the reaction inspectors 220a, 220b, ..., and 220l and the polarization states of the light emitted from the reaction detectors 220a, 220b, ..., and 220l and collected by the photodetector 264, To operate differently, a known beam splitter can be applied. At this time, the beam splitter can be disposed on the optical path between the light source 262 and the reaction inspection strip 20 and on the optical path between the reaction inspection strip 20 and the photodetector 264. The beam splitter may reflect only the light polarized in the first direction among the light incident from the light source 262 to the beam splitter and provide the reflected light to the reaction inspection units 220a, 220b, ..., and 220l. The beam splitter transmits the light polarized in the second direction out of the light again emitted from the reaction inspection units 220a, 220b, ..., 220l by the polarized light in the first direction, .

Figure 13 is a schematic representation of a reaction test apparatus using a reaction test strip according to another embodiment of the present disclosure; Referring to FIG. 13, the reaction testing apparatus 1300 may not include a separate position reading apparatus 250.

When the reaction inspection strip 80 moves in the direction M1 on the strip converging device 240, the photographing apparatus 260 uses the light source 262 and the photodetector 264 to control the reaction inspection section (not shown) on the body section 210 220a, 220b, ..., 220l can be read. Specifically, the photographing apparatus 260 can distinguish the images of the boundary regions of the reaction inspection sections 220a, 220b, ..., and 220l from the surface on the background image of the one surface of the body section 210. [ Therefore, the photographing apparatus 260 captures the moment when the reaction inspection strip 80 enters the boundary of the reaction inspecting sections 220a, 220b, ..., 220l from the background image of the one surface of the body section 210 during movement can do. At the same time, the photographing apparatus 260 can photograph images of the reaction inspecting sections 220a, 220b, ..., and 220l.

As described above, the image pattern formed by the interface between the body 210 and the reaction inspectors 220a, 220b, ..., 220l on one side of the body 210 can function as a positional information marker. In this manner, the photographing apparatus 260 can simultaneously perform the role of the position reading apparatus for reading the image pattern, and simultaneously transmit the photographing signal to the photodetector 264.

As described above, the inspection method using the reaction inspection apparatus can be diluted through the following steps. A reaction test strip and a positional information marker disposed at a position corresponding to the position of the reaction test strip. Next, a position reading device is disposed adjacent to the reaction inspection strip, and the reaction inspection strip is moved at a constant speed or acceleration in one direction, and the reaction inspection strip is allowed to move through the position reading device. Next, in synchronism with the timing at which the position information marker is detected by the position reading device, the reaction inspection part is photographed using the photographing device.

While the present invention has been particularly shown and described with reference to exemplary embodiments thereof, it will be understood by those of ordinary skill in the art that various changes in form and details may be made therein without departing from the spirit and scope of the invention as defined by the appended claims. It can be understood that

10 20 30 32 34 40 42 44 50 60 70 80: Strip for reaction test
1200 1300: reaction test equipment,
105: body portion, 110 120 130 140 150: plural reaction sites,
160: urine, 170: container,
210: body portion, 220a 220b ... 220l: reaction test section,
232a 232b ... 232l, 234a 234b ... 234l: Location information markers,
240: Strip transducer, 250: Position reader,
252a 252b: sensor,
260: photographing device, 262: light source, 264: photodetector,
330a 330b ... 330l: location information marker,
332a 332b 332c 333a 333b ... 333l 334a 334b ... 334l: location information marker,
350 360: Position reading device, 362: Light source, 364: Photodetector,
41 42 43 44: first to fourth segments,
41s 42s 43s 44s: first to fourth switches,
41t, 42t, 43t, 44t: first to fourth buttons,
410 412 414 416: first to fourth bodies,
420a 420b 420c ... 420l: reaction test section,
440 540: Strip converters,
442, 444, 446, 448: first to fourth rails,
550: position reading device,
51 52 53 54: first to fourth segments,
51s 52s 53s 54s: first to fourth switches,
530a 530b ... 530l: first pad,
535h 535g: resistance pattern,
550a: Fixing portion, 550b: Sensing portion,
631 g 632 g 633 g: first pad, 635 g: resistance pattern,
730h1 730h2 ... 730h6, 730g1 730g2 ... 730g6: first pad,
735h 735g: Resistance pattern.

Claims (16)

A body portion having a predetermined width, height and length;
A plurality of reaction inspectors arranged along the length direction of the body part on one side of the body part and providing the result of the reaction with the target material as color information; And
And a position information marker disposed on a surface of or inside the body corresponding to the position of the reaction inspecting part and providing position information of the reaction inspecting part to the position reading device,
Wherein the position information markers comprise at least one of an optical signal pattern, a physical structure pattern, an electrical circuit pattern, and an image pattern
Strip for reaction test.
The method according to claim 1,
The optical signal pattern
And a bar code disposed on a surface of the body corresponding to the positions of the plurality of reaction inspection units
Strip for reaction test.
The method according to claim 1,
The physical structure pattern
And a protruding structure or a concave structure disposed on a side portion of the body portion corresponding to the positions of the plurality of reaction inspection portions
Strip for reaction test.
The method according to claim 1,
The physical structure pattern
And a stepped pattern having the different width along the longitudinal direction of the body part
Strip for reaction test.
The method according to claim 1,
The electrical circuit pattern
And a resistance pattern disposed under the plurality of reaction inspection units,
Wherein the resistance pattern changes depending on the contact with the position reading apparatus
Strip for reaction test.
The method according to claim 1,
The image pattern
And a pattern formed by the interface between the body portion and the reaction inspection portion on one side of the body portion,
And is read by edge detection of the position reading apparatus
Strip for reaction test.
A reaction test strip having a reaction test part and a positional information marker disposed at a position corresponding to a position of the reaction test part;
A position reading device disposed adjacent to the reaction inspection strip and detecting the position information markers of the reaction inspection strip when the reaction inspection strip moves at a constant speed or acceleration in one direction; And
And a photographing device which photographs the reaction inspection part in synchronization with the timing at which the position reading device detects the position information markers,
Wherein the position information markers comprise at least one of an optical signal pattern, a physical structure pattern, an electrical circuit pattern, and an image pattern
Reaction testing device.
8. The method of claim 7,
The reaction test strip
A body portion having a predetermined width, height and length,
The reaction inspection unit may include a plurality of reaction inspection units arranged along a longitudinal direction of the body part on one side of the body part and providing a reaction result with the target material as color information,
Wherein the position information marker is disposed on a surface or inside of the body part, and provides position information of the reaction inspection part to the position reading device
Reaction testing device.
9. The method of claim 8,
Wherein the position information marker includes a barcode as an optical signal pattern on a side portion of the body portion,
When the reaction inspection strip moves through the position reading device, the position reading device reads the bar code and transmits a photographing signal to the photographing device
Reaction testing device.
9. The method of claim 8,
Wherein the position information marker includes a protruding structure or a concave structure disposed on a side surface of the body portion,
When the reaction inspection strip moves through the position reading device, the position reading device reads an image of the protruding structure or the concave structure and transmits a photographing signal to the photographing device
Reaction testing device.
9. The method of claim 8,
Wherein the positional information marker has the step portion of the different width along the longitudinal direction of the body portion,
When the step portion contacts the reaction inspection strip moving through the position reading device, the position reading device sequentially transmits the photographing control signal to the photographing device
Reaction testing device.
9. The method of claim 8,
Wherein the position information marker includes a resistance pattern disposed under the plurality of reaction inspection units,
The position reading apparatus transmits the photographing control signal to the photographing apparatus when the electrical resistance changes due to the contact of the resistance pattern with the reaction inspection strip moving through the position reading apparatus
Reaction testing device.
9. The method of claim 8,
Wherein the position information marker includes an image pattern formed by the body part and the interface between the reaction part and the reaction part on one side of the body part,
When the reaction test strip moves through the position reading device, the position reading device reads the image pattern and transmits a photographing signal to the photographing device
Reaction testing device.
8. The method of claim 7,
The photographing apparatus
A light source for providing visible light or ultraviolet light; And
And a photodetector disposed adjacent the light source and having a color sensor
Reaction testing device.
15. The method of claim 14,
Wherein the light source comprises a first polarizing filter polarized in a first direction,
Wherein the photodetector comprises a second polarizing filter polarized in a direction perpendicular to the first direction
Reaction testing device.
15. The method of claim 14,
Further comprising a beam splitter disposed on an optical path between the light source and the reaction inspection strip and an optical path between the reaction inspection strip and the photodetector,
The light polarized in the first direction from the light source is incident on the reaction inspection unit and light polarized in the direction perpendicular to the first direction among the light scattered from the reaction inspection unit is detected by the photodetector
Reaction testing device.

KR1020150036679A 2015-03-17 2015-03-17 strip for inspecting reaction, inspection apparatus of strip KR20160111693A (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108663321A (en) * 2018-04-02 2018-10-16 迈克医疗电子有限公司 A kind of measuring head, the urine dry chemistry Analyzer and its detection method
WO2019107666A1 (en) * 2017-11-29 2019-06-06 한양대학교 산학협력단 Urine test strip comprising timer, and method for detecting and analyzing urine test strip

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019107666A1 (en) * 2017-11-29 2019-06-06 한양대학교 산학협력단 Urine test strip comprising timer, and method for detecting and analyzing urine test strip
KR20190062775A (en) * 2017-11-29 2019-06-07 한양대학교 산학협력단 Urine test strip including timer, method for detecting and analyzing urine test strip
US11333658B2 (en) 2017-11-29 2022-05-17 Industry-University Cooperation Foundation Hanyang University Urine test strip comprising timer, and method for detecting and analyzing urine test strip
CN108663321A (en) * 2018-04-02 2018-10-16 迈克医疗电子有限公司 A kind of measuring head, the urine dry chemistry Analyzer and its detection method
CN108663321B (en) * 2018-04-02 2024-04-05 迈克医疗电子有限公司 Test head, urine dry chemical analyzer and detection method thereof

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