KR20140146985A

KR20140146985A - Liquid toothpaste composition

Info

Publication number: KR20140146985A
Application number: KR1020130121417A
Authority: KR
Inventors: 문교태; 유아람; 하원호; 이인호
Original assignee: 주식회사 엘지생활건강
Priority date: 2013-06-18
Filing date: 2013-10-11
Publication date: 2014-12-29
Also published as: KR102026942B1

Abstract

The present invention relates to a low viscosity liquid toothpaste composition including an abrasive and liquid polyol and having excellent viscosity retentivity. The purpose of the present invention is to provide a toothpaste composition which inhibits increase of viscosity by preventing liquid toothpaste from being dried and improves hardening of contents. Accordingly, the toothpaste composition can be used without hardening caused by change of viscosity, thereby improving convenience in use.

Description

[0001] Liquid toothpaste composition [0002]

The present invention relates to a dentifrice composition, and more particularly to a liquid dentifrice composition having improved drying properties.

Originally developed in Colgate, USA, paste toothpaste was sold in aluminum tubes and was still in use by the 1970s. The development of the paste-like dentifrice containers made of aluminum as a laminated film material as in modern times can be said to be the development of the polymer and polymer processing technology. However, in the case of such a tubular toothpaste, there is a real inconvenience in use due to the remaining amount at the time of tube discharge and the viscosity of the pasty product. In order to improve the releasability of such toothpaste, a liquid toothpaste product having properties of flowing in a plastic container has been developed.

However, as the liquid toothpaste products naturally increase in contact with the air, drying phenomenon occurs, resulting in an increase in viscosity.

As the viscosity of the liquid toothpaste increases, the settling phenomenon occurs, and the initial formulation is not maintained, resulting in inconvenience in use.

Therefore, studies have been made to prevent the phenomenon of solidification of the contents while maintaining convenience in use of the liquid toothpaste.

SUMMARY OF THE INVENTION Accordingly, the present invention has been made to solve the above-mentioned problems and to provide a liquid dental composition having excellent viscosity retention.

In particular, the present invention aims to provide a dentifrice composition which prevents the liquid toothpaste from drying out, suppresses an increase in viscosity, and improves the hardening of contents.

Further, the present invention is intended to improve the convenience of use by allowing the dentifrice composition to be used without hardening due to changes in viscosity or the like.

In order to solve the above problems, the present invention provides a liquid dentifrice composition comprising an abrasive and a liquid polyol, preferably an abrasive and a liquid polyol together to maintain a constant viscosity of the contents, .

As used herein, the term "viscosity" refers to the viscosity of a liquid dentifrice composition. The term "viscosity retention" means the degree to which the viscosity of the liquid toothpaste is constant during at least two years, Lt; RTI ID = 0.0 > cP. &Lt; / RTI >

The abrasive contained in the dentifrice composition of the present invention is a material which functions to remove plaque in the oral cavity and must be used essentially to increase the removal efficiency of tooth plaque and remove hard foreign substances etc. When the Mohs hardness is 3 ~ 6. &Lt; / RTI >

The abrasive is contained in an amount of 0.1 to 30% by weight, preferably 1 to 20% by weight, based on the total weight of the dentifrice composition of the present invention. If the content of the abrasive is less than 0.1% by weight, the toothpaste will not exhibit polishing power because it does not exhibit a polishing degree. If the abrasive content exceeds 30% by weight, sufficient washing power can not be obtained compared with the content, .

The abrasive may include any one selected from the group consisting of calcium monohydrogenphosphate, precipitated silica, fumed silica, colloidal silica, zeolite, calcium carbonate, hydrated alumina, kaolin, cellulose, and mixtures thereof.

The liquid dentifrice composition of the present invention further comprises a liquid polyol in addition to the above abrasive.

The liquid polyol refers to a polyol that is present in a liquid state at room temperature, such as sugar alcohol, which does not exhibit wetting characteristics when dissolved in water.

The liquid polyol prevents the drying phenomenon that may occur when the liquid toothpaste comes into contact with air, thereby keeping the viscosity of the liquid toothpaste constant and thus preventing the hardening of the contents.

The liquid polyol may be contained in an amount of 30 to 80% by weight, preferably 40 to 75% by weight, based on the total weight of the dentifrice composition of the present invention.

When the content of the liquid polyol is less than 30% by weight, the dentifrice composition hardens easily. In particular, the content is hardly discharged from the container due to hardening of the contents. On the other hand, if it exceeds 80% by weight, the specific gravity of the liquid polyol component in the entire dentifrice composition is too high to cause problems in viscosity formation, resulting in defective formation of the beads or phase separation of the abrasive.

The liquid polyol may include any one selected from the group consisting of PEG (polyethylene glycol) 200 to 600, glycerol, propylene glycol, ethylene glycol, polypropylene glycol, and mixtures thereof.

The dentifrice composition of the present invention may contain, in addition to the above-mentioned abrasive and liquid polyol, the dentifrice composition of the present invention as a typical component depending on the formulation and purpose of use, such as a flavor, a sweetener, a pharmacological agent, a pH adjuster, And the like.

A flavoring agent and a sweetening agent may be added to the composition of the present invention to suit the taste of the consumer. Flavors remain in the mouth and continue to emit fragrance so that the exhilaration can continue.

Melt such as peppermint and spearmint, wintergreen, methyl salicylate, yugenol, melon, strawberry, orange, vanillin and the like can be used as the flavoring agent.

In general, the flavoring agent may be used in the range of 0.001 to 10% by weight of the total composition weight.

In addition, a sweetening agent may be added to the composition of the present invention to overcome the basic taste that the formulation may have. The sweetener keeps saliva in the oral cavity by continuing to provide taste.

As the sweetening agent, saccharine, sucralose, sugar, xylitol, sorbitol, lactose, mannitol, maltitol, erythritol, aspartame, taurine, saccharin salt and D-tryptophan may be used alone or in combination. Among saccharin salts, saccharin sodium is the most widely used. The amount of the sweetener is generally in the range of 0.001 to 20% by weight based on the total weight of the composition.

The medicinal effective agent used for oral hygiene may be a composition having effects such as prevention of tooth decay, prevention of gum disease, prevention of dental calculus deposition, and whitening. Medicinal products for tooth decay include compounds recognized as safe by the US Food and Drug Administration, including fluoride ions. Compounds that can be used as a source of fluoride ions include sodium fluoride, sodium fluorophosphate, tin fluoride, and ammonium fluoride.

Although the content of fluorine may vary depending on the country, it is common to use a mixture of one or more of these sources so as to have a fluoride ion concentration preferably in the range of 850 to 1500 ppm.

Remineralizers may also act as a preventative for cavities. Remineralization plays a role in regenerating and restoring hydroxyapatite, a major component of teeth. The main component of hydroxyapatite consists of divalent calcium cations and phosphate anions. Therefore, if calcium ion or phosphate ion is supplied at the same time, or calcium ion or phosphate anion is contained in the oral cavity to move the hydroxyapatite to the side where the chemical equilibrium is generated, it can be a remineralizing agent. The material providing calcium and phosphorus is selected from the group consisting of hydroxyapatite, calcium phosphate dibasic, calcium chloride, casein phosphopeptide, calcium glycerophosphate, sodium phosphate monobasic, sodium phosphate dibasic, sodium monophosphate, potassium monophosphate, Potassium phosphate dibasic, potassium phosphate dibasic and the like. In general, it is preferable to use the resealing agent in the range of 0.001 to 20% by weight of the total composition. If the amount is less than 0.001% by weight, the effect of re-crystallization is deteriorated. If the amount is more than 20% by weight, the properties inherent to the formulation are lost.

One of the purposes of using oral hygiene products is to prevent gum disease as well as to alleviate gum disease which is progressing through sterilization or anti-inflammatory action of harmful microorganisms in oral cavity which are alive in the oral cavity. For this purpose, it is possible to use isopropylmethylphenol, cyclohexidine, cetylpyridinium chloride, triclosan, xanthorizole and the like which are known as antimicrobial agents. In order to have anti-inflammatory action, vitamins and enzymes, aminocaproic acid, Derivatives and the like can also be used. The pharmaceutical agent is characterized by containing 0.005 wt% to 5 wt%. When the content of the active agent is less than 0.005, it is difficult to exhibit its effect. When the content exceeds 5% by weight, the taste of the basic base is changed.

In addition to gum disease, hydrogen peroxide, carbamide peroxide, and calcium peroxide, which exhibit a whitening effect, can be used. Sodium pyrophosphate, sodium pyrophosphate, sodium pyrophosphate, sodium metaphosphate and the like are also used to obtain dental deposit inhibition effect. Generally, these pharmacologically active agents are generally used in the range of 0.001 to 10% by weight of the total weight of the composition.

As the pH adjusting agent, phosphoric acid, sodium phosphate, citric acid, sodium citrate, succinic acid, sodium succinate, tartaric acid, sodium tartrate and the like can be used, and the acidity of the composition for oral use is generally 5 to 8.

As the binding agent, carboxymethyl cellulose sodium, carbomer, carrageenan, xanthan gum, alginates, etc. may be used alone or in combination of two or more. The amount of such a binder to be used is generally 0.1 to 5% by weight, preferably 0.5 to 3% by weight, based on the total weight of the oral composition.

As the preservative, benzoic acid, methylparaben, propylparaben, sodium benzoate and the like can be used.

Examples of the foaming agent include sodium alkylsulfate, sodium laurylsulfate, alkylsulfuric acid, laurylsulfuric acid, cocoyl glutamate sodium salt, myristoyl glunamate sodium salt, cocamidopropyl betaine, sucrose fatty acid ester, sorbitan fatty acid ester , Polyoxyethylene polyoxypropylene copolymer (poloxamer), and the like can be used alone or in combination of two or more.

The amount of the foaming agent to be used is generally 0.2 to 5% by weight, preferably 0.5 to 3.5% by weight, based on the total weight of the oral composition.

The brightener is titanium oxide, suitably used in an amount of 0.1% to 2% by weight.

The method for producing the dentifrice composition of the present invention can be produced according to a method conventionally produced in the art.

The dentifrice composition according to the present invention provides a liquid dentifrice composition excellent in feeling and excellent in viscosity retention.

Also disclosed is a liquid dentifrice composition which improves disadvantages of a liquid dentifrice composition which is inconvenient due to stagnation due to contact with air or sudden change in viscosity.

Hereinafter, the present invention will be described in more detail with reference to the following examples. However, the embodiments according to the present invention can be modified into various other forms, and the scope of the present invention should not be construed as being limited to the above-described embodiments. The embodiments of the present invention are provided by way of example to facilitate a specific understanding of the present invention.

Example 1-6 and Comparative Example 1-3

The dentifrice compositions of Examples and Comparative Examples were prepared with the components and composition ratios shown in Table 1 below. The powder components such as pharmacologically active agent, xanthan gum, saccharin, preservative and surfactant are completely dispersed in purified water, liquid polyol and flavor solution, and then the mixture is mixed with a polishing agent and an active agent such as silica and mixed under a vacuum condition A dentifrice composition was prepared.

Unit weight% Example
One Example
2 Example
3 Example
4 Example
5 Example
6 Comparative Example
One Comparative Example
2 Comparative Example
3 Precipitated silica 1.00 5.00 10.00 20.00 - - 20.00 20.00 5.00 Calcium carbonate - - - - 30 - Calcium hydrogen phosphate - - - - - 30 glycerin 45.00 45.00 45.00 45.00 45.00 45.00 10.00 85.00 70% solution of sorbitol 45.00 45.00 Sodium lauryl sulfate 2.00 2.00 2.00 2.00 2.00 2.00 2.00 2.00 2.00 Sodium saccharin 0.20 0.20 0.20 0.20 0.20 0.20 0.20 0.20 0.20 Paraoxybenzoic acid ester 0.15 0.15 0.15 0.15 0.15 0.15 0.15 0.15 0.15 Xanthan gum 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 Sodium fluoride 0.22 0.22 0.22 0.22 0.22 0.22 0.22 Sodium fluorophosphate 0.76 0.76 Vitamin E 0.20 0.20 0.20 0.20 0.20 0.20 0.20 0.20 0.20 Spices 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 Purified water 49.23 45.23 40.23 30.23 19.69 19.69 20.23 30.23 5.23

Example 7-12 and Comparative Example 4-5

The dentifrice compositions of Examples and Comparative Examples were prepared with the components and composition ratios shown in Table 2 below. The liquid ingredients such as purified water and liquid polyol, and the fragrant liquid are completely dispersed and mixed with the powder components such as the phar- maceutical agent, xanthan gum, saccharin, preservative and surfactant, and then the abrasive such as silica and the phar- maceutical agent are added, To produce a dentifrice composition.

Example
7 Example
8 Example
9 Example
10 Example
11 Example
12 Comparative Example
4 Comparative Example
5 Precipitated silica 15.00 15.00 15.00 15.00 15.00 15.00 20.00 15.00 Polyethylene glycol 300 60.00 5 40 5 glycerin - 60.00 55 50 20.00 Propylene glycol 60.00 20 5 Sorbitol - 60.00 Sodium lauryl sulfate 2.00 2.00 2.00 2.00 2.00 2.00 2.00 2.00 Sodium saccharin 0.20 0.20 0.20 0.20 0.20 0.20 0.20 0.20 Paraoxybenzoic acid ester 0.15 0.15 0.15 0.15 0.15 0.15 0.15 0.15 Xanthan gum 1.50 1.50 1.50 1.50 1.50 1.50 1.00 1.50 Sodium fluoride 0.22 0.22 0.22 0.22 0.22 0.22 0.22 0.22 Vitamin E 0.20 0.20 0.20 0.20 0.20 0.20 0.20 0.20 Spices 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 Purified water 19.73 19.73 19.73 19.73 19.73 19.73 55.23 19.73

Viscosity change with time

In order to observe the viscosity change with time of the dentifrice composition prepared according to Examples and Comparative Examples of Tables 1 and 2, the following experiment was conducted.

Viscosity measurement

The viscosity changes of the dentifrices prepared in Examples 1 to 12 and Comparative Examples 1 to 5 in Tables 1 and 2 were measured immediately after the preparation and in the pump-type container after 1 month and 12 months, respectively, using a Brookfield viscometer RVT type spindle 7, the viscosity was measured while rotating the rotating speed at a rate of 10 rotations per minute. The results are shown in Table 3 below.

Viscosity (X 1000 cP) Early 1 month 12 months Example 1 34 35 35 Example 2 32 36 35 Example 3 32 32 39 Example 4 33 35 37 Example 5 34 37 37 Example 6 32 36 37 Example 7 31 35 38 Example 8 33 32 35 Example 9 32 35 35 Example 10 33 36 36 Example 11 31 32 35 Example 12 33 36 38 Comparative Example 1 35 51 rigidity Comparative Example 2 35 55 rigidity Comparative Example 3 - - - Comparative Example 4 35 45 200 or more Comparative Example 5 35 81 rigidity

According to Comparative Examples 1 and 2 including sorbitol, the viscosity of the toothpaste was inevitably measured when the toothpick was allowed to stand at room temperature for 12 months, and even after one month, rapid viscosity change due to moisture evaporation Was observed.

However, as shown in Examples 1 to 4, even when the content of the abrasive increases with the change of the abrasive content, the change of the viscosity is not so significant, and the abrasive content does not appear to have a significant effect on the viscosity over time.

In addition, as in the results of Examples 8 and 9, no remarkable change in viscosity with time was observed even in the case of viscosity change depending on the type of liquid polyol.

According to the results of Comparative Example 4, it was confirmed that when the liquid polyol having a low content was contained, the viscosity change with time was remarkably observed. According to the result of Comparative Example 1, when the low liquid polyol and the solid polyol were contained simultaneously It was found that the viscosity increased sharply and then the problem of hardening occurred after a long period of time. This suggests that the low-content liquid polyol can maintain the discharge characteristics at the initial stage, but it can be confirmed that the discharge is difficult over time.

According to the results of Comparative Example 3, when the content of the liquid polyol was 85 wt% or more, there was a problem that the solids were separated after the preparation of the dentifrice, resulting in a degree that the viscosity could not be measured.

It was also confirmed that the discharge characteristics were not changed when the dip pump was used due to abrupt viscosity change even when the kind and content of the abrasive and the liquid polyol were used. Therefore, it has been confirmed that a combination of a liquid polyol and an abrasive can use liquid toothpaste in an air-permeable container without a sudden change in viscosity or hardening phenomenon.

Of dip pump Discharge

The dentifrice compositions prepared by the methods of Examples 1 to 12 and Comparative Examples 1 to 4 were applied to a pump container having a capacity of 250 milliliters, and the discharging characteristics were evaluated by continuously pumping the remaining amount to 20 grams or less. The results are shown in Table 4.

Discharge characteristic Early 1 month 12 months Example 1 Discharge completed Discharge completed Discharge completed Example 2 Discharge completed Discharge completed Discharge completed Example 3 Discharge completed Discharge completed Discharge completed Example 4 Discharge completed Discharge completed Discharge completed Example 5 Discharge completed Discharge completed Discharge completed Example 6 Discharge completed Discharge completed Discharge completed Example 7 Discharge completed Discharge completed Discharge completed Example 8 Discharge completed Discharge completed Discharge completed Example 9 Discharge completed Discharge completed Discharge completed Example 10 Discharge completed Discharge completed Discharge completed Example 11 Discharge completed Discharge completed Discharge completed Example 12 Discharge completed Discharge completed Discharge completed Comparative Example 1 150 milliliters 80 milliliters No discharge Comparative Example 2 200 milliliters 120 milliliters No discharge Comparative Example 3 200 milliliters 115 milliliters No discharge Comparative Example 4 150 milliliters 80 milliliters No discharge

As a result of evaluating the discharge characteristics with respect to the content of sorbitol used as a comparative example and the abrasive content, it was confirmed that no discharge could be performed after about 150 milliliters of the initial viscosity had been discharged. After one month of increasing viscosity, the viscosity increased and the discharge amount decreased by about 50%. After one year, it was confirmed that the discharge was no longer caused by the hardening phenomenon.

In Comparative Examples 1 and 4, in which the liquid polyol was used at a critical concentration or lower, a lot of characteristics were observed at the beginning of the aging period compared to the case of using only sorbitol, but as a result, As the time passed, the discharge rate rapidly decreased.

From the above results, it can be seen that the viscosity is not increased due to the solidifying polyol.

On the other hand, when the liquid polyol is used, it is shown that the abrasive is continuously discharged irrespective of aging or not. This is because the liquid polyol contained in the dentifrice composition containing the liquid polyol in the amount of 30 wt% .

Claims

An abrasive and a liquid polyol,
Viscosity liquid holding toothpaste composition.

The method according to claim 1,
Wherein the abrasive is contained in an amount of 0.1 to 30% by weight based on the total weight of the composition.

The abrasive according to claim 1, wherein the abrasive is any one selected from the group consisting of calcium monohydrogenphosphate, precipitated silica, fumed silica, colloidal silica, zeolite, calcium carbonate, hydrated alumina, kaolin, cellulose and mixtures thereof &Lt; / RTI >

The dentifrice composition according to claim 1, wherein the liquid polyol is contained in an amount of 30 to 80% by weight based on the total weight of the composition.

The dentifrice composition according to claim 1, wherein the liquid polyol is any one selected from the group consisting of PEG (polyethylene glycol) 200 to 600, glycerol, propylene glycol, ethylene glycol, polypropylene glycol, and mixtures thereof.

6. The dentifrice composition according to any one of claims 1 to 5, wherein the polyol has a role of preventing drying of the liquid dentifrice composition and / or inhibiting viscosity increase.

6. The dentifrice composition according to any one of claims 1 to 5, wherein the liquid dentifrice composition has a viscosity change of 100 to 15,000 cP.