KR20140137960A

KR20140137960A - Vitamin C derivative and manuka oil surface treated composite powder for skin-whitening and wrinkle-care

Info

Publication number: KR20140137960A
Application number: KR1020130059290A
Authority: KR
Inventors: 이범주; 이승우; 정순규; 허탁; 박민임
Original assignee: 주식회사 케미랜드
Priority date: 2013-05-24
Filing date: 2013-05-24
Publication date: 2014-12-03

Abstract

The present invention relates to composite particles for skin-whitening and wrinkle care and, more specifically, to composite particles which are applied with functional foods such as vitamin C derivative and manuka oil and the like. The present invention provides a multi-functional cosmetic composition which has skin-whitening and anti-inflammatory activities as vitamin C derivative and manuka oil do, and is obtained by the steps of manufacturing nanoemulsion including the vitamin C derivative or manuka oil; checking phase stability of the nanoemulsion obtained from the above step; coating the nanoemulsion including the functional foods with inorganic powder; quantifying contents of the vitamin C derivative from the vitamin C derivative coated powder obtained from the above step and quantifying contents of organic matters from the manuka oil coated powder; analyzing particle size of the functional foods coated powder; and checking skin-whitening and wrinkle care effects through animal experiments. The present invention improves phase stability and keeps the coated organic matters intact.

Description

[0001] The present invention relates to vitamin C derivatives and manuka oil surface-treated composite powders for skin whitening and wrinkle-care,

The present invention relates to a composite powder for whitening and wrinkle improvement, and more particularly to a composite powder to which a functional raw material such as a vitamin C derivative and a Manuka oil is applied.

As consumers' income and intellectual level have increased recently, the standard of preference for cosmetics has changed significantly from the past. If past cosmetics were a means to pursue psychological satisfaction by changing their external appearance more beautifully, current cosmetics are being developed and sold with more specialized and specific functions, and the demand for functional cosmetics is increasing. %.

Currently, the functional cosmetics product group is divided into the product group of whitening function, wrinkle improving function, ultraviolet ray blocking function, and complex formulations having two or more of the above three functions at the same time. However, current demand for cosmetics has also diversified, and the current cosmetics market is constantly in demand for products that can improve skin troubles such as moisture-enhancing products and acne as well as the above-mentioned four functional products.

Vitamin C (ascorbic acid) among whitening functional ingredients is one of the most effective whitening functional ingredients. However, vitamin C is easily oxidized by physical and chemical factors such as heat, light, and metal, and its activity is easily lost. To overcome these drawbacks, vitamin C derivatives with various functional groups attached to vitamin C are currently being used as whitening functional ingredients in the cosmetics market.

Ascorbyl tetraisopalmitate is a combination of ascorbic acid and tetraester of isopalmitic acid. It is a fat soluble vitamin C derivative in which four fatty acids are combined with vitamin C.

Ascorbyl tetraisopalmitate has antioxidant ability in addition to whitening effect, which prevents oxidation of protein and lipid peroxide formation. When vitamin C derivatives and vitamin E are used together in the manufacture of cosmetics, it not only facilitates absorption in the skin but also prevents the formation of oxidation products in the formulations, thereby helping to stabilize the ingredients. Ascovill tetraisopalmitate can be applied to whitening products, anti-aging creams, eye creams and other anti-wrinkle products.

On the other hand, Manuka Oil (Manuka oil) is Leptospermum It is derived from a plant with the scientific name of Scoparium and is a viscous red oil with a unique odor. Recently, since the strong antibacterial activity of Manuka oil has been known, this raw material is now attracting attention as a raw material for antimicrobial properties present in nature. The main ingredients with antibacterial activity in manuka oil are triketones, flavesone, leptospermone, and isoleptospermone, which are influenced by the concentration of these components. Manuka oil has been reported to have excellent antibacterial activity against antibacterial, antifungal, anti-inflammatory and antibiotic-resistant organisms. In addition, studies on manuka honey have been actively conducted by a number of researchers, and there is a strong antimicrobial activity in manuka honey. Staphylococcus aureus, which causes infection such as impetigo (infectious disease of skin) It is known to have excellent antibacterial activity.

To date, various functional ingredients such as whitening and wrinkle improvement have been mainly applied to basic cosmetic products. Vitamin C derivatives and wrinkle-improving raw materials have been applied to formulations such as skins, lotions, creams, and essences, and many functional products have been developed and sold. However, it is difficult to find functional powder cosmetics with such effective ingredients. Until now, most of the powder cosmetics belonging to functional products are all UV protection products.

For a composition containing a peptide-bound vitamin C derivative, Korean Patent Registration No. 10-0691540 is disclosed and a nano-emulsified cosmetic composition containing vitamin C derivatives developed by the present inventors is disclosed in Korean Patent No. 10-0949848 Lt; / RTI > On the other hand, Korean Patent No. 10-0362896 discloses an external preparation for antibacterial, anti-inflammation and skin protection containing manuka oil as a main component. However, none of the above documents discloses a composite powder in which a nanoemulsion containing a vitamin C derivative or a Manuka oil is coated on an inorganic powder.

Accordingly, an object of the present invention is to provide a method for producing a nano emulsion containing a whitening and wrinkle-reducing functional raw material and a method for producing a coated powder using the nano emulsion.

Another object of the present invention is to provide a whitening and wrinkle-reducing functional coating powder prepared by the above method and a composite powder using the same.

The above object of the present invention can be achieved by a method for producing a nanoemulsion containing vitamin C derivative or manuka oil, Confirming the degree of appearance of the nano emulsion obtained in the step; Coating an inorganic powder with a nano emulsion containing a functional raw material; Quantifying vitamin C derivative content in the vitamin C derivative-coated powder obtained in the above step and quantifying the organic matter content in the Manuka oil-coated powder; Analyzing the particle size of the functional material coated powder; Animal experiments were conducted to confirm the effect of whitening and wrinkle improvement.

The vitamin C derivative in the vitamin C derivative-containing nanoemulsion of the present invention may be used in an amount of 2 to 10% by weight.

In the Manuka oil-containing nanoemulsion of the present invention, the Manuka oil may be used in an amount of 2 to 10% by weight, preferably 10% by weight.

Ingredients conventionally included in the nanoemulsion of the present invention include paraffin oil, squalane, squalene, capric capric triglyceride, cetyl octanoate, octyldodecanol, isopropyl palmitate, jojoba oil, olive oil, Safflower oil, Waluko colostrum, Colostrum, Pasol 1789, Parabenzoic acid propyl, and Para benzoic acid methyl.

The nanoemulsion composition of the present invention is useful as an emulsifying agent for skin creams, lotions, essences, body lotions, emulsified body oils and baby oils, sunscreen creams and lotions, suntan tanning creams and lotions, emulsifying self- , Make-up base and the like, emulsifying cream of external medicine, skin bleaching product of lotion formulation, wrinkle improving product and the like.

The present invention has an effect of providing a multi-functional cosmetic composition having efficacy such as whitening and anti-inflammation such as vitamin C derivatives and manuka oil, and has an excellent effect of improving safety and maintaining the coated organic material.

FIG. 1 is a process diagram illustrating a nanoemulsion manufacturing process using a water-soluble vitamin C derivative.
FIG. 2 is a process drawing illustrating a process for manufacturing a nanoemulsion using Manuka oil.
Fig. 3 is a photograph showing the degree of appearance of a water-soluble vitamin C derivative-containing common emulsion and a nano emulsion.
Fig. 4 is a photograph showing the degree of appearance of the normal emulsion and nano emulsion containing Manuka oil. Fig.
FIG. 5 is a diagram showing a process for producing a coating powder by applying a functional material-containing nanoemulsion.
Fig. 6 is a photograph showing the state of phase-separation of the water-soluble vitamin C-containing coating powder.
FIG. 7 is a photograph showing the state of phase separation of the coating powder containing the Manuka oil.
8 is a photograph showing the state of phase separation of the coating material containing Blank (reference material) and oil-soluble vitamin C derivatives.
9 is a photograph showing the transparency of the filtrate after coating the functional raw material.
10 is a graph showing an organic matter quantitation (TG-DSC) of a water-soluble vitamin C derivative-containing composite powder.
Fig. 11 is a graph showing an organic matter quantification (TG-DSC) of the composite powder containing the Manuka oil.
Fig. 12 is a graph showing correlation between the coating concentration and the organic content of the Manuka oil composite powder.
FIG. 13 is a graph showing an organic matter content (TG-DSC) of a blank (standard sample) and a fat-soluble vitamin C derivative-containing composite powder.
Fig. 14 is a result of quantifying the content of Ethyl Ascorbyl Ether in the nano emulsion.
FIG. 15 is a graph showing the correlation of measured values of ethyl ascorbic ether to the concentration of vitamin C derivative added to the emulsion.
FIG. 16 shows the result of quantitative determination of vitamin C in the coating powder of the vitamin C derivative.
17 is a D50 value and particle size distribution diagram of blank (standard sample) coated powder.
18 is a D50 value and a particle size distribution diagram of a 2 wt% coated powder of a water-soluble vitamin C derivative.
19 is a D50 value and a particle size distribution diagram of a 5 wt% coating powder of a water-soluble vitamin C derivative.
20 is a D50 value and a particle size distribution diagram of a 10% by weight coating powder of a water-soluble vitamin C derivative.
21 is a D50 value and a particle size distribution diagram of a 2 wt% coated powder of the Manuka oil.
22 is a D50 value and a particle size distribution diagram of a 5 wt% coated powder of Manuka oil.
23 is a D50 value and a particle size distribution diagram of a 10 wt% coated powder of Manuka oil.
24 is a D50 value and a particle size distribution diagram of a 10 wt% coating powder of a fat-soluble vitamin C derivative.
25 is a graph showing changes in the thickness of the skin of the photoautotized mouse skin.
26 is a graph comparing melanin production inhibitory effects of DMSO and control group composite powder.
27 is a graph comparing melanin production inhibitory effects of water-soluble and fat-soluble vitamin C derivative-coated powders.
28 is a graph showing the effect of suppressing melanin formation in the Manuka oil-coated powder.

Hereinafter, the present invention will be described in detail with reference to Examples and Experimental Examples, but the present invention is not limited to these Examples. The compounding amount is expressed by weight unless otherwise specified.

Example 1: Nano-containing vitamin C derivatives Emulsion Produce

The purified water was heated to 80 to 90 ° C, and then hydrogenated lecithin was added thereto and dispersed. Separately, a fat-soluble raw material was dissolved in 1,3-BG (butylene glycol) to prepare a whitening functional raw material dispersion. The whitening functional raw material dispersion is added to the hydrogenconed lecithin dispersion solution and the liposomization reaction is started using a homo mixer. The liposomized reaction is firstly cooled, then the whitening functional raw material is added and the emulsion is prepared through a general emulsification process And then cooled to room temperature. The nano emulsion treatment was performed twice through a microfludizer (M / F) and the mixture was allowed to stand until it became phase-separated in an emulsion emulsion. Then, the emulsion was cooled to room temperature to prepare a vitamin C derivative-containing nanoemulsion (FIG.

Example 2: Manuka Oil-containing nano Emulsion Produce

Purified water is heated to 80 to 90 ° C, hydrogenated lecithin is added, and manuka oil and oil-soluble raw material are dissolved in 1,3-BG (butylene glycol). Then, the hydrogenconed lecithin dispersion solution And emulsified through a liposomal reaction. After cooling to room temperature through primary emulsification, the mixture was subjected to M / F treatment twice to prepare a nanoemulsion, followed by cooling and cooling (room temperature) to prepare a nanoemulsion containing manuka oil (FIG. 2).

Experimental Example 1: Containing Vitamin C Derivatives Emulsion Phase stability test

Phase stability was compared between normal emulsion and nano emulsion properties, ie, whether sediments and different interfaces were formed or color differences. According to the method of Preparation Example 1, the water-soluble vitamin C derivative-containing general emulsion was prepared in three concentrations of 2% by weight, 5% by weight and 10% by weight and treated twice with a microfludizer (MF) (Fig. 3).

As a result of the comparison between the general emulsion containing vitamin C derivatives and the nano emulsion, the nano emulsion was more transparent and more transparent than the normal emulsion in the full concentration sample group. The stability of the phase was also more stable and uniform than that of the nano - treated samples.

In the emulsions with the concentrations of 2% by weight and 5% by weight, the phase stability was not visually significant, but the emulsions with the concentration of 10% by weight showed a remarkable difference. Especially, the color difference between the upper and lower layers in the 5% general emulsion was confirmed. In other words, although it was not phase separated, it was found that the upper part was pale yellowish while the lower part was dark yellow and the stability was not better than the nano emulsion. The normal emulsion having a concentration of 10% by weight was filled with air bubbles in the upper layer, but no air bubbles were generated in the nano emulsion.

Experimental Example 2: Manuka Oil contain Emulsion Phase stability test

According to the method of Preparation Example 2, the general emulsion containing Manuka oil was prepared at three concentrations of 2% by weight, 5% by weight and 10% by weight and then treated twice with a microfludizer (MF) to prepare a nano emulsion (Fig. 4).

As a result of the comparison of the Manuka oil containing general emulsion and the nano emulsion, as the concentration of the Manuka oil increased, a large amount of precipitated particles occurred in the general emulsion, but no precipitated particles were observed in the nano emulsion regardless of the concentration of the Manuka oil. As the concentration of manuka oil increased, the color of the emulsion changed to dark yellow while the nano emulsion had a constant milky white color irrespective of the concentration of Manuka oil.

Nano emulsion containing 10% by weight of Manuka oil showed no phase separation as compared to the normal emulsion, and the generic and nano emulsion containing Manuka oil showed a lot of color difference compared to the emulsion containing vitamin C derivative.

Example 3: Nano Emulsion weapon In powder Coating process

This coating process is a process of coating a nano emulsion stabilized with a functional raw material onto a powder, and is capable of coating various functional raw materials on the powder (Fig. 5).

3-1 Application of water-soluble vitamin C derivative of different concentration Coating Powder Produce

The water-soluble vitamin C derivative emulsion containing 2 wt%, 5 wt% and 10 wt% prepared in Example 1 was coated on the inorganic powder (Fig. 6).

As a result of the phase separation of the coating powder obtained in the above process, it was confirmed that the phase separation proceeded smoothly in all of the composite powders coated at the three concentrations. The smaller the amount of coating powder, the more easily the phase separation proceeded as the amount of purified water increased.

3-2 Different concentrations of Manuka Oil Application Coating Powder Produce

The composite powder was prepared using the Manuka oil emulsion containing 2% by weight, 5% by weight and 10% by weight, prepared in Example 2, and then phase separation was confirmed (FIG. 7). It was confirmed that the functional ingredient of Manuka oil was well coated as the phase separation between powder and purified water proceeded normally and the transparency of the upper part of the Manuka oil was good at the low concentration and the upper part became slightly cloudy as the concentration of the Manuka oil increased. The higher the concentration of Manuka oil and the lower the powder content, the faster the phase separation between the purified water and the powder was.

3-3 Blank , Oil-soluble vitamin C derivative coating Powder Produce

Blank (standard sample) and oiliness Nano emulsion containing vitamin C derivatives was coated on the inorganic powder, and phase separation was confirmed (FIG. 8).

As a result of the observation, it was confirmed that the coating was normally proceeded due to the normal phase separation.

Experimental Example 3: Checking the transparency of the filtrate

In order to confirm whether the nanoemulsion was normally coated on the inorganic powder, the phase separated coating solution prepared in Example 3 was filtered and the transparency of the filtrate was observed (FIG. 9).

As a result of observation, the transparency of the filtrate after coating with the water-soluble vitamin C derivative and the Manuka oil was not much different from that of the purified water. In particular, the two sample groups coated with 10 wt% concentration showed slightly lower transparency than the other sample groups. The transparency of the filtrate after the powder coating of Blank and ascorbyl tetrapalmitate was similar to that of the other coating powders.

Experimental Example 4: TG - DSC Quantification of organic matter using

4-1 Water-Soluble Vitamin C Derivatives Coating powder

The organic matter content of the composite powder coated with the water-soluble vitamin C derivative was determined using a differential scanning calorimeter (TG-DSC: STA409PC Luxx) with a thermogravimetry coupled differential scanning calorimeter (TG-DSC).

As shown in FIG. 10, the organic matter content was generally lower than the coating concentration of the water-soluble vitamin C derivative, and the water-soluble vitamin C derivative was found to be lost numerically.

In all three graphs, the endothermic reaction proceeded with the peak pointing downward, and the weight deduction began at temperatures above 100 ° C for all three peaks (TG peak at the back of the graph).

4-2 Manuka Oil Coating powder

The organic matter content of the Manuka oil-coated powder was measured using TG-DSC (Fig. 11), which was higher than the organic content of the water-soluble vitamin C derivative. All of the three coating powders proceeded to the endothermic reaction and the weight began to be deducted at over 100 ℃.

In particular, the correlation of the organic matter content with the coating concentration in the Manuka oil coating powders having different concentrations was confirmed (FIG. 12). As the coating concentration was increased, the organic matter measurement value also increased proportionally and positively correlated Respectively.

4-3 Blank And fat-soluble vitamin C derivatives Coating powder

The sample obtained in Example 3-3 was filtered and dried, and then an organic substance was quantified using TG-DSC (FIG. 13).

In FIG. 13, the DSC graph of both samples also proceeded to endothermic reaction with the peak pointing downward. In the case of blank without added functional material, weight loss of organic matter was 3.12% and weight loss of 14.75% in fat - soluble vitamin C derivative powder.

Experimental Example 5: Nano Emulsion of mine Coating powder My Vitamin C Quantitation

5-1 Nano containing vitamin C derivatives Emulsion

The content of ethyl ascorbyl ether and ascorbyl tetrapalmitate in nanoemulsions with different concentrations of vitamin C derivatives was determined to confirm that the vitamin C derivatives were properly coated.

This experiment was quantified according to the "functional cosmetics standards and test methods" notified by the Korea Food & Drug Administration (KFDA) and commissioned by Korea Institute of Construction & Living Environment Test (Fig. 14).

As a result of the quantitative analysis, the amount of vitamin C added was quantitatively determined. In particular, in the case of the vitamin C derivative of 5% by weight or less, the functional ingredient was detected in almost the same amount as the added vitamin C derivative, . As a result of measurement of ascorbate tetrapalmitate, which is a fat-soluble vitamin C derivative, about 93% remained in the emulsion. In the nanoemulsion prepared by this experiment, the water-soluble and fat-soluble vitamin C derivatives were added in an amount of 90 % Or more (Table 1).

As can be seen from FIG. 15, the correlation between the content of the water-soluble vitamin C derivatives measured at different concentrations confirmed that all of the vitamin C derivatives added in the emulsion remained in the emulsion.

5-2 Containing Vitamin C Derivatives Coating powder Quantification of Vitamin C Derivatives

The content of the vitamin C derivative in the composite powder coated with the vitamin C derivative was quantified in the same manner as in Experimental Example 5-1, and is shown in FIG.

As a result, the content of water soluble vitamin C derivatives coated on the inorganic powders was not detected in less than 1% in all three sample groups. The content of the useful vitamin C derivative in the composite powder coated with ascorbyltetraisopalmitate was 7.65%, which was 82.5% of the content of the coating material (Table 2).

Experimental Example 6: Functional raw materials Of the coated powder Particle size analysis

Particle size analysis was performed to determine the particle size of the functional raw coating powder (particle size analyzer: microtrac, S3500, USA).

6-1 Blank Of the coated powder Particle size

The particle size was measured by setting the coated powder not containing only the functional material to the raw material as blank (FIG. 17).

As a result, the D50 value was found to be 24 ㎛, which was more than 3 times higher than the particle size before coating (about 7.0 ㎛).

6-2 Water-Soluble Vitamin C Derivatives Of the coated powder Particle size

2% by weight of the water-soluble vitamin C derivative was coated on the inorganic powder and the particle size was checked. As a result, it was confirmed that the D50 value was about 11, which was about 1.5 times larger than the raw material before the coating treatment (FIG.

The size of the particles coated with 5 wt% of the water-soluble vitamin C derivative on the inorganic powder was about 10.70 mu m in D50 (Fig. 19).

The D50 value of the particles obtained by coating 10 weight% of the water-soluble vitamin C derivative on the inorganic powder was about 11.08 占 퐉 (Fig. 20).

6-3 Manuka Oil Of the coated powder Particle size

The average particle size of the composite powder coated with 2 wt% of the Manuka oil was about 8.0 탆, which was only 1 탆 larger than the uncoated raw material (Fig. 21).

The D50 value of the composite powder coated with 5 wt% of the Manuka oil was about 8.72 mu m, showing no significant difference from the 2 wt% coated powder of the Manuka oil (Fig. 22).

It was confirmed that the D50 value of the 10 wt% coated Manuka oil was 10.89 mu m and the particle size was significantly increased compared to the 5 wt% coated powder of Manuka oil (Fig. 23).

6-4 Fatty soluble vitamin C derivatives Of the coated powder Particle size

10% by weight of a fat-soluble vitamin C derivative (VC-IP, ascorbyl tetraisopalmitate) was coated on an inorganic powder and the particle size of the composite powder was confirmed to be 11.93 탆 (Fig. 24).

6-5 Different functional materials coated Composite powder Particle size

Blank coating powder was 23.93 ㎛ and the particle size was the largest. 2 wt% coating powder of Manuka oil had the smallest particle size of 8.00 ㎛. The water - soluble vitamin C derivative - coated powder showed a larger particle size than the Manuka oil - coated powder.

Experimental Example 7: In the composite powder Wrinkle improvement effect

A mouse (SKH-1 Hairless Mouse, Female) that promoted artificial photo-aging through UV-B irradiation was selected as an animal test subject. The water-soluble and fat-soluble vitamin C derivatives and the coating powder of Manuka oil were dispersed in ester oil and applied to the hind legs and the back of the mice evenly for 9 weeks, thereby confirming the wrinkle-improving effect of the mice.

In measuring the thickness of the skin of the mouse, the mouse was anesthetized with ether and the skin of the dorsal central part was overlapped using a caliper. The measurement interval was 0, 2, 4, 6, 8, 5 times.

As a result of skin thickness measurement, in case of composite powder coated with 10% by weight of fat soluble vitamin C derivative, the thickest skin was formed for 6 to 8 weeks, which is far from the effect of improving wrinkles. It was confirmed that when the talc manco 10% (10 wt% coated powder of manuka oil) was dispersed in the ester oil, the skin thickness became the thinnest. In the case of the mouse without any treatment, the skin thickness did not change significantly for 9 weeks. The sample coated with the ester oil and the blank composite powder dispersed in the ester oil showed little wrinkle improving effect (FIG. 25).

Experimental Example 8: Functional substance Of the coated powder Whitening functional effect

B16F10 melanoma cells were used for the inhibition of melanin pigment synthesis. B16F10 melanoma cells were inoculated in DMEM medium containing 10% FBS at a rate of 1 × 10 ⁵ cells per well, (37 ° C, 5% CO ₂ ). After the medium was replaced, the functional raw material powder was treated by concentration. After 48 hours of incubation, melanin was measured (Hosoi method, 1985). Cells were washed twice with PBS buffer and centrifuged to form cell precipitate. After addition of 200 μL of 1 N NaOH containing 10% DMSO and dissolution at 80 ° C. for 1 hour, absorbance was measured at 490 nm.

The addition of DMSO inhibited the production of melanin pigment by 30%, while the control group composite powder contained 300 ㎍ of B16F10 melanoma cell inoculated with DMSO and control group composite powder. To inhibit 35% of melanin pigment formation (Fig. 26).

Soluble vitamin C coating powder and the fat soluble vitamin C coating powder were added to the media to which B16F10 melanoma cells were inoculated at different concentrations. When 30 μg of the water-soluble vitamin C coating powder was added, 300 μg of the water-soluble vitamin C derivative powder was added 50% and 55% inhibition of melanin pigment formation. In the case of water - soluble vitamin C derivative coated powder, the inhibitory effect on melanin pigment formation was little in the remaining concentration except 30 ㎍, whereas the fat soluble vitamin C derivative coated powder showed inhibition of melanin pigment formation by at least 40% at all concentrations except 300 ㎍ It was confirmed that the fat-soluble vitamin C derivative-coated powder than water-soluble inhibited the production of melanin pigment (Fig. 27).

In the case of Manuka oil coated powders, melanin pigment inhibitory effect was shown to be 45 ~ 85% at all added concentrations, and 85% melanin pigment formation inhibitory effect was confirmed especially when 150 and 300 μg were added (FIG. 28).

Claims

Adding hydrogenated lecithin and an oil-soluble raw material dispersion to warm-treated purified water to initiate a liposomization reaction;
Adding the vitamin C derivative 2 to 10% by weight after the first mixture is cooled at 40 to 50 ° C;
Cooling the mixture to room temperature after the first emulsification, and twice performing the nanoemulsion treatment using a microfluidizer;
And cooling the emulsified composition obtained in the above step at a fixed temperature and at a room temperature to obtain a water-soluble and fat-soluble vitamin C derivative-containing nanoemulsion.

Adding liposomal to the warmed purified water by adding a solution containing hydrogencontent lecithin and an oil-soluble raw material and 10% by weight of a manuka oil;
Cooling the composition obtained in the above step to a room temperature after primary emulsification, and twice performing nano emulsification treatment using a microfluidizer;
And then cooling the emulsified composition obtained in the above step at a fixed temperature and at a room temperature to obtain a nano emulsion containing the Manuka oil.

3. The method according to claim 1 or 2,
The oil-soluble raw material is selected from the group consisting of paraffin oil, squalane, squalene, capric capric triglyceride, cetyl octanoate, octyldodecanol, isopropyl palmitate, jojoba oil, olive oil, safflower oil, 1789, propyl para-benzoate, and methyl para-benzoate.

3. The method according to claim 1 or 2,
Wherein the formulation of the nanoemulsion is selected from the group consisting of skin creams, lotions, essences, body lotions, emulsified body oils or baby oils, sunscreen creams or lotions, suntan tanning creams or lotions, emulsified self- , A makeup base, a skin bleaching product of an emulsion type cream or a lotion formulation, or a wrinkle improvement product.

A water-soluble vitamin C derivative-containing nanoemulsion composition prepared by the method of claim 1.

A nano emulsion composition containing a Manuka oil prepared by the method of claim 2.

Adding inorganic powders to purified water subjected to warming treatment;
Adding a vitamin C derivative composition prepared according to the method of the fifth aspect or a manuka oil containing nano emulsion composition prepared according to the method of the sixth aspect to the mixture obtained in the step;
Stirring the composition with a homomixer, and cooling and cooling at room temperature;
Filtering and drying the composition at 80 to 85 ° C and pulverizing the composition;
And filtering the composition with a mesh of 100 mesh.

7. A whitening and wrinkle-improving composite powder coated with a vitamin C derivative-containing nanoemulsion prepared by the method of claim 7.

9. A cosmetic composition for whitening and wrinkle improvement, which comprises the composite powder of claim 8 as an active ingredient.