KR20140083424A - Cosmetic composition for cutis elastica or skin-moisture containing eriodictyol - Google Patents
Cosmetic composition for cutis elastica or skin-moisture containing eriodictyol Download PDFInfo
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- KR20140083424A KR20140083424A KR1020120153152A KR20120153152A KR20140083424A KR 20140083424 A KR20140083424 A KR 20140083424A KR 1020120153152 A KR1020120153152 A KR 1020120153152A KR 20120153152 A KR20120153152 A KR 20120153152A KR 20140083424 A KR20140083424 A KR 20140083424A
- Authority
- KR
- South Korea
- Prior art keywords
- skin
- cosmetics
- cosmetic composition
- eriodictyol
- skin moisturizing
- Prior art date
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- 239000002537 cosmetic Substances 0.000 title claims abstract description 50
- 239000000203 mixture Substances 0.000 title claims abstract description 27
- SBHXYTNGIZCORC-UHFFFAOYSA-N eriodyctiol Natural products O1C2=CC(O)=CC(O)=C2C(=O)CC1C1=CC=C(O)C(O)=C1 SBHXYTNGIZCORC-UHFFFAOYSA-N 0.000 title claims abstract description 20
- MZSGWZGPESCJAN-MOBFUUNNSA-N Melitric acid A Natural products O([C@@H](C(=O)O)Cc1cc(O)c(O)cc1)C(=O)/C=C/c1cc(O)c(O/C(/C(=O)O)=C/c2cc(O)c(O)cc2)cc1 MZSGWZGPESCJAN-MOBFUUNNSA-N 0.000 title claims abstract description 19
- TUJPOVKMHCLXEL-UHFFFAOYSA-N eriodictyol Natural products C1C(=O)C2=CC(O)=CC(O)=C2OC1C1=CC=C(O)C(O)=C1 TUJPOVKMHCLXEL-UHFFFAOYSA-N 0.000 title claims abstract description 19
- 235000011797 eriodictyol Nutrition 0.000 title claims abstract description 19
- SBHXYTNGIZCORC-ZDUSSCGKSA-N eriodictyol Chemical compound C1([C@@H]2CC(=O)C3=C(O)C=C(C=C3O2)O)=CC=C(O)C(O)=C1 SBHXYTNGIZCORC-ZDUSSCGKSA-N 0.000 title claims description 12
- 208000002197 Ehlers-Danlos syndrome Diseases 0.000 title 1
- 230000003020 moisturizing effect Effects 0.000 claims abstract description 39
- 150000003839 salts Chemical class 0.000 claims abstract description 13
- 230000037394 skin elasticity Effects 0.000 claims abstract description 12
- -1 eriodictyol compound Chemical class 0.000 claims abstract description 9
- 239000004480 active ingredient Substances 0.000 claims abstract description 8
- 239000006071 cream Substances 0.000 claims description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 9
- 239000006210 lotion Substances 0.000 claims description 8
- 238000000034 method Methods 0.000 claims description 7
- 230000002708 enhancing effect Effects 0.000 claims description 4
- 239000000126 substance Substances 0.000 claims description 4
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- 239000006260 foam Substances 0.000 claims description 2
- 239000002453 shampoo Substances 0.000 claims description 2
- 239000007921 spray Substances 0.000 claims description 2
- 239000000344 soap Substances 0.000 claims 1
- 230000001737 promoting effect Effects 0.000 abstract 1
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- 238000004519 manufacturing process Methods 0.000 description 24
- 150000003573 thiols Chemical class 0.000 description 15
- 239000002253 acid Substances 0.000 description 10
- 238000007796 conventional method Methods 0.000 description 9
- 239000004615 ingredient Substances 0.000 description 9
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- 239000000843 powder Substances 0.000 description 9
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- 239000011734 sodium Substances 0.000 description 7
- 229910052708 sodium Inorganic materials 0.000 description 7
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 6
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- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 4
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- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 4
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- 238000002360 preparation method Methods 0.000 description 4
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- 235000014121 butter Nutrition 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 210000002615 epidermis Anatomy 0.000 description 3
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- 239000000463 material Substances 0.000 description 3
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- 239000004408 titanium dioxide Substances 0.000 description 3
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 2
- JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical compound OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 description 2
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- 239000004909 Moisturizer Substances 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 description 2
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- 229940082500 cetostearyl alcohol Drugs 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 210000004207 dermis Anatomy 0.000 description 2
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 229940075529 glyceryl stearate Drugs 0.000 description 2
- DWMMZQMXUWUJME-UHFFFAOYSA-N hexadecyl octanoate Chemical compound CCCCCCCCCCCCCCCCOC(=O)CCCCCCC DWMMZQMXUWUJME-UHFFFAOYSA-N 0.000 description 2
- 239000003906 humectant Substances 0.000 description 2
- 239000010445 mica Substances 0.000 description 2
- 229910052618 mica group Inorganic materials 0.000 description 2
- 150000007522 mineralic acids Chemical class 0.000 description 2
- 230000001333 moisturizer Effects 0.000 description 2
- 150000007524 organic acids Chemical class 0.000 description 2
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 2
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 2
- 239000001818 polyoxyethylene sorbitan monostearate Substances 0.000 description 2
- 235000010989 polyoxyethylene sorbitan monostearate Nutrition 0.000 description 2
- 229920000053 polysorbate 80 Polymers 0.000 description 2
- 239000000377 silicon dioxide Substances 0.000 description 2
- 229920002545 silicone oil Polymers 0.000 description 2
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 2
- 125000004079 stearyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
- 239000000454 talc Substances 0.000 description 2
- 229910052623 talc Inorganic materials 0.000 description 2
- OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 description 2
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- PZNPLUBHRSSFHT-RRHRGVEJSA-N 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCCCC(=O)O[C@@H](COP([O-])(=O)OCC[N+](C)(C)C)COC(=O)CCCCCCCCCCCCCCC PZNPLUBHRSSFHT-RRHRGVEJSA-N 0.000 description 1
- LFESLSYSZQYEIZ-UHFFFAOYSA-N 3-octanoyloxybutyl octanoate Chemical compound CCCCCCCC(=O)OCCC(C)OC(=O)CCCCCCC LFESLSYSZQYEIZ-UHFFFAOYSA-N 0.000 description 1
- OHCSOVPGPHRIAN-UHFFFAOYSA-N C(C)C(CCCC(O)O)(CC)CC Chemical compound C(C)C(CCCC(O)O)(CC)CC OHCSOVPGPHRIAN-UHFFFAOYSA-N 0.000 description 1
- 240000008067 Cucumis sativus Species 0.000 description 1
- 235000010799 Cucumis sativus var sativus Nutrition 0.000 description 1
- XMSXQFUHVRWGNA-UHFFFAOYSA-N Decamethylcyclopentasiloxane Chemical compound C[Si]1(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O1 XMSXQFUHVRWGNA-UHFFFAOYSA-N 0.000 description 1
- 239000009429 Ginkgo biloba extract Substances 0.000 description 1
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 1
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 1
- 235000018330 Macadamia integrifolia Nutrition 0.000 description 1
- 240000000912 Macadamia tetraphylla Species 0.000 description 1
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- ZONYXWQDUYMKFB-UHFFFAOYSA-N SJ000286395 Natural products O1C2=CC=CC=C2C(=O)CC1C1=CC=CC=C1 ZONYXWQDUYMKFB-UHFFFAOYSA-N 0.000 description 1
- 244000044822 Simmondsia californica Species 0.000 description 1
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- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 235000003704 aspartic acid Nutrition 0.000 description 1
- 230000003796 beauty Effects 0.000 description 1
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid group Chemical group C(C1=CC=CC=C1)(=O)O WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 1
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 description 1
- SXDBWCPKPHAZSM-UHFFFAOYSA-N bromic acid Chemical compound OBr(=O)=O SXDBWCPKPHAZSM-UHFFFAOYSA-N 0.000 description 1
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- 239000004359 castor oil Substances 0.000 description 1
- 235000019438 castor oil Nutrition 0.000 description 1
- 210000002808 connective tissue Anatomy 0.000 description 1
- 229940086555 cyclomethicone Drugs 0.000 description 1
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- 239000002552 dosage form Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
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- 125000003976 glyceryl group Chemical group [H]C([*])([H])C(O[H])([H])C(O[H])([H])[H] 0.000 description 1
- KWIUHFFTVRNATP-UHFFFAOYSA-N glycine betaine Chemical compound C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 description 1
- 235000020688 green tea extract Nutrition 0.000 description 1
- 229940094952 green tea extract Drugs 0.000 description 1
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- 230000014759 maintenance of location Effects 0.000 description 1
- 239000002480 mineral oil Substances 0.000 description 1
- 235000010446 mineral oil Nutrition 0.000 description 1
- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 description 1
- 229930014626 natural product Natural products 0.000 description 1
- 239000010466 nut oil Substances 0.000 description 1
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- 235000005985 organic acids Nutrition 0.000 description 1
- 229940066842 petrolatum Drugs 0.000 description 1
- 235000019271 petrolatum Nutrition 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 229920001495 poly(sodium acrylate) polymer Polymers 0.000 description 1
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- 229940023866 safflower seed extract Drugs 0.000 description 1
- 230000009759 skin aging Effects 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
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Images
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Dermatology (AREA)
- Botany (AREA)
- Mycology (AREA)
- Nutrition Science (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Birds (AREA)
- Cosmetics (AREA)
Abstract
The present invention relates to a cosmetic composition for skin moisturizing or skin elasticity enhancement containing an eriodictyol compound or its salt as an active ingredient, wherein the erodic thiol compound or its salt according to the present invention continuously And can be used as a cosmetic composition for promoting the elasticity of the skin.
Description
The present invention relates to a cosmetic composition for skin moisturizing or skin elasticity enhancement containing an eriodictyol compound or its salt as an active ingredient.
The outer skin (Epidermis) is functionally divided into the stratum corneum, the transparent layer, the granular layer, and the basal layer from the outside to the inside. The dermis in the inner part is dense connective tissue and the hypodermis inside the dermis It serves to fix the skin to the internal organs. Among them, epidermis is the thinnest layer among the three skin structures, and it is a function to moisturize and protect the skin, and research on skin beauty has been actively carried out.
It has been reported that the skin layer of the epidermis must have an essential moisture content of 10% or more, and the thickness of the stratum corneum varies depending on the content.
The cells that make up this stratum corneum have a high concentration of Natural Moisturizing Factor (NMF), which is a water-soluble component, which helps the skin to maintain flexibility and maintain proper moisture. For example, The material is not only water-soluble, but also effectively combines with moisture to inhibit moisture from drying out of the skin. However, due to various causes such as age, sex, concrete area, continuous stimulation of the environment, and external stimuli such as increased stress, the moisture of the stratum corneum is decreased and the skin becomes dry, the surface becomes rough, The need for skin moisturizers is increasing.
The major cause of skin aging is known to be influenced by various factors such as the content of various polysaccharides in the skin and the immune action ability to the external environment. One of the major influences is skin moisture content have.
Conventionally, a method of increasing water retention has been widely used by using a humectant having a property of absorbing moisture as a humectant and an occlusive moisturizer preventing evaporation of water. In addition, the formulations containing the lamellar liquid crystals, which have been undergoing much research until recently, are known to have excellent moisture retention due to their similar merits to the keratinous structures of the skin, but they can be manufactured only in a specific composition of the raw materials and thus have problems in universal use.
In the cosmetics industry, technologies featuring skin moisturization are being published through numerous papers and patents, and are being industrialized in a wide variety of products. Generally, a moisturizing function using a natural extract is applied to skin moisturizing cosmetic materials such as cucumber extract, carrot extract, green tea extract, safflower seed extract, marchia extract, ginkgo leaf extract, Cream, essence, packy, etc. are widely available as a product. However, skin moisturizing ingredients using these extracts are mostly extracts rather than a single substance because of their characteristics, so that it is difficult to identify a clear ingredient.
The inventors of the present invention have completed the present invention by confirming that the eriodictol compound is a single substance and has an excellent effect of sustaining skin moisturization.
An object of the present invention is to provide a cosmetic composition for enhancing skin moisturization or skin elasticity containing an eriodictyol compound or its salt as an active ingredient.
In order to achieve the above object, the present invention provides a cosmetic composition for skin moisturizing or skin elasticity enhancement containing an eriodictyol compound or its salt as an active ingredient, which can increase flexibility and elasticity by continuously maintaining moisture of the skin .
The eriodictyol compound or its salt according to the present invention can be used as a cosmetic composition for improving the elasticity of the skin by continuously maintaining moisture of the skin.
FIG. 1 is a graph showing the skin moisturizing effect of a cream type cosmetic preparation containing an erodic thiol according to the present invention measured by MY-808S Moisture Checker (Scalar, Japan).
FIG. 2 is a graph showing the skin moisturizing effect of a serum type cosmetic preparation containing an erodic thiol according to the present invention measured by MY-808S Moisture Checker (Scalar, Japan).
The present invention provides a cosmetic composition for skin moisturizing or skin elasticity enhancement comprising an eriodictyol compound represented by the following formula (1) or a salt thereof as an active ingredient:
[Chemical Formula 1]
In the present invention, the eriodictyol compound is a kind of flavanone, and its IUPAC name is (2S) -2- (3,4-dihydroxyphenyl) -5,7-dihydroxy-4-chromanone, Has a molecular formula of C 15 H 12 O 6 and a molecular weight of 288.25.
The erio-thiol compound according to the present invention can be used in the form of a salt, preferably a pharmaceutically acceptable salt, wherein the salt is preferably an acid addition salt formed by a pharmaceutically acceptable free acid As the free acid, an organic acid and an inorganic acid can be used.
The organic acids include, but are not limited to, citric, acetic, lactic, tartaric, maleic, fumaric, formic, propionic, oxalic, trifluroacetic, benzoic, gluconic, methosulfonic, glycolic, succinic, Glutamic acid and aspartic acid. The inorganic acid includes, but is not limited to, hydrochloric acid, bromic acid, sulfuric acid, and phosphoric acid.
In addition, the erio-thiol compound of the present invention can be isolated from natural materials or can be prepared by a chemical synthesis method known in the art, and commercially available erio-thiol thiol compounds can be commercially obtained and used.
In addition, the pharmaceutical composition of the present invention does not have toxicity and is harmless to the human body because it comprises a component separated from a natural product extract or a derivative thereof as an active ingredient.
The pharmaceutical dosage forms of the eriodic thiols according to the present invention may be used in the form of their pharmaceutically acceptable salts and may also be used alone or in combination with other pharmaceutically active compounds as well as in suitable aggregates.
In one embodiment according to the present invention, the cosmetic composition for enhancing skin moisturization or skin elasticity is characterized in that the eriodictyol is 0.000001 to 1% by weight of the total cosmetic composition.
In one embodiment according to the present invention, the cosmetic composition for skin moisturizing or skin elasticity enhancement is characterized in that the eriodictyol is 0.00005 to 0.01 wt% of the total weight of the cosmetic composition.
In one embodiment according to the present invention, the cosmetic composition for enhancing skin moisturization or skin elasticity is characterized in that the eriodictyol is 0.00001 to 0.001% by weight of the total cosmetic composition weight.
In one embodiment according to the present invention, the composition of the cosmetic composition includes at least one of a skin, a lotion, a cream, an essence, an emulsion, a gel, a lipstick, a cleansing foam, a cleansing cream, a cleansing water, a spray, a shampoo, a rinse, a treatment, a body cleanser, , A pack, a massager, a face powder, a compact, a foundation, a two-way cake, and a makeup base.
Hereinafter, the present invention will be described in more detail with reference to the following Experimental Examples and Preparation Examples. It should be understood, however, that the same is by way of illustration and example only and is not intended to limit the scope of the present invention.
[Experimental Example 1] Skin moisturizing effect test of eriodic thiol
A cream and serum containing 0.0006% of powder of pure eriodictyol were made to perform a skin moisturizing test. MY-808S Moisture Checker (Scalar, Japan) was used for the skin moisturizing effect and clinical examination was performed using the inside of the forearm.
In the method of measuring the moisture resistance, the skin moisturizing power before application was checked including the control group, and the skin moisturizing power after 1 hour, 2 hours, 3 hours, and 4 hours after each sample was applied at 0.25 g / cm 2 was measured. The skin moisturizing ability was very sensitive to temperature and humidity, so it was conducted in a constant temperature and humidity room where the temperature was 20 and the humidity was 60%. The subjects were tested in 20 male and 5 female subjects.
[Results of skin moisturizing test using MY-808S Moisture Checker]
First, the results of the first test with the MY-808S Moisture Checker are shown in FIG. As shown in FIG. 1, there was a skin moisturizing effect that was increased to 32.88% after application to a skin having a skin moisturizing power of 29.52% before application in a cream containing 0.0006% pure eriodictyol single powder, As a result, it was found that the skin moisturizing effect after 4 hours was maintained almost the same level as that after wearing.
In addition, as shown in FIG. 2, in the serum containing 0.0006% of pure eriodictyol single powder, skin moisturizing effect was increased to 30.5%, and then to 33.54% The skin moisturizing effect was confirmed to maintain the skin moisturizing effect after the lapse of 4 hours to almost the same level.
The reason is that the eriodic thiol covers the surface of the stratum corneum to prevent the loss of moisture of the skin, and it is interpreted that the moisturizing effect is maintained due to the holding effect of the skin moisture.
On the other hand, as shown in FIG. 1 and FIG. 2, there was a higher moisturizing effect in a serum containing 0.0006% of pure erythrodithiol single powder than cream containing 0.0006% of pure erioidic eriodictyol single powder.
Production Example 1. Skin moisturizing skin preparation
0.2% by weight of erythorbic thiol
Baisaka Ride Sword 1.0
Sodium Hyaluronic Acid 3.0
Ethylenediaminetetraacetic acid 0.02
Citric acid 0.05
Sodium citrate 0.35
Imidazolidinyl urea 0.2
Dipropylene glycol 3.0
Para-oxy methylene-protected castor oil 0.06
Polyoxyethylene sorbitan monostearate 0.1
Fragrance quantity
Pigment amount
Purified water balance
Using the above ingredients, the skins were prepared according to the conventional method in the field of cosmetics for making skins.
Manufacturing Example 2. Skin moisturizing lotion manufacturing
0.2% by weight of erythorbic thiol
Paraoxybenzoic acid methyl 0.2
Ethylenediaminetetraacetic acid 0.02
1,3-butylene glycol 0.02
Allantoin 3.0
Sodium Hyaluronic Acid Seed 5.0
Carbomer 0.1
Cetostearyl alcohol 0.7
P-hydroxybenzoic acid propyl 0.1
Sorbitan olivate 1.5
Soy lecithin 0.2
Dimethicone 0.2
Cetyl octanoate 0.2
Share Butter 0.2
Sodium placrylate 3.0
Triethanolamine 0.1
Imidazolidinyl urea 0.3
Fragrance quantity
Pigment amount
Purified water balance
The above ingredients were used to make lotions according to the conventional method in the field of cosmetics for making lotions.
Production Example 3. Production of skin moisturizing essence
0.2% by weight of erythorbic thiol
Allantoin 0.05
Ethylenediaminetetraacetic acid 0.02
Triethanolamine 0.2
Sodium Hyaluronic Acid 7.0
Imidazolidinyl urea 0.15
Sodium polyacrylate 0.4
Carbomer 0.2
Ethanol 3.0
0.2% polyoxyethylene sorbitan monostearate
Paraoxybenzoic acid methyl 0.2
Fragrance quantity
Pigment amount
Purified water balance
The above ingredients were used to prepare the essence according to the conventional method in the field of cosmetic production for essence production.
Production Example 4. Production of skin moisturizing cream
0.2% by weight of erythorbic thiol
Ethylenediaminetetraacetic acid 0.02
Allantoin 0.1
Glycerin 5.0
Paraoxybenzoic acid methyl 0.2
Sodium Hyaluronic Acid 6.0
Carbomer 0.1
Cetostearyl alcohol 1.7
Polydecene 2.0
Squalane 2.0
P-hydroxybenzoic acid propyl 0.1
Butylene glycol dicaprylate 3.0
Cetyl octanoate 5.0
Microcrystalline rinse 0.1
Triethylpentanediol 0.1
Share Butter 0.2
Sorbitan olivate 0.3
Cyclomethicone 0.3
Stearyl dimethicone 0.5
Imidazolidinyl urea 0.15
Fragrance quantity
Pigment amount
Purified water balance
The ingredients were used to make creams according to the conventional methods in the cosmetic manufacturing field for making creams.
Production Example 5. Production of skin moisturizing pack
0.2% by weight of erythorbic thiol
Ethylenediaminetetraacetic acid 0.02
Betain 3.0
Glyceryl polymethacrylate 2.0
Allantoin 0.1
Sodium Hyaluronic Acid 2.0
Glycerin 3.0
Dipropylene glycol 5.0
Paraoxybenzoic acid methyl 0.2
Polyvinyl alcohol 10.0
Polyoxyethylene sorbitan monooleate 0.9
Sesquioleic acid 0.3
Jojoba ester 2.0
Cetearyl Alcohol 1.5
Petrolatum 0.5
Fragrance quantity
Pigment amount
Purified water balance
The packs were prepared according to the conventional method in the field of cosmetics for making a pack using the above ingredients.
Manufacturing Example 6. Skin moisturizing cleansing lotion manufacturing
0.2% by weight of erythorbic thiol
Ethylenediaminetetraacetic acid 0.02
Paraoxybenzoic acid methyl 0.2
Glycerin 4.0
Sodium Hyaluronic Acid 2.0
Propylene glycol 3.0
Carbomer 5.0
Cetearyl alcohol 0.7
Glyceryl stearate 0.5
Share Butter 1.0
P-hydroxybenzoic acid propyl 0.1
Macadamia Nut Oil 1.0
Sesquioleic acid 0.5
Glyceryl stearate 1.0
Polyoxyethylene sorbitan monooleate 2.0
Polydecene 5.0
Mineral oil 20.0
Dimethicone 5.0
Stearyl Dimethicone 2.0
Triethanolamine 0.05
Fragrance quantity
Pigment amount
Purified water balance
Cleansing lotions were prepared according to the conventional methods in the field of cosmetic production for the production of cleansing lotions using the above ingredients.
Production Example 7. Production of skin moisturizing make-up base
0.2% by weight of erythorbic thiol
Coated Silica 1.0
Silica 10.0
Titanium dioxide 8.0
Zinc oxide 3.0
Pigment 1.0
Plate Powder Residue
A makeup base was prepared according to a conventional method in the field of cosmetic production for making makeup base using the above components.
Production Example 8. Production of Skin Moisturizing Powder Fact
0.2% by weight of erythorbic thiol
Mica 15.0
Titanium dioxide 7.0
Silicone Oil 3.0
Esther Oil 3.0
Pigment amount
Fragrance quantity
Talc residue
The powder facts were prepared according to a conventional method in the field of cosmetic production for the powder fact using the above-mentioned components.
Production Example 9. Production of skin moisturizing two-way cake
0.2% by weight of erythorbic thiol
Mica 15.0
Titanium dioxide 12.0
Silicone Oil 3.0
Ester oil 5.0
Pigment amount
Fragrance quantity
Talc residue
Two-way cakes were prepared according to the conventional method in the field of cosmetics for making two-way cakes using the above ingredients.
Claims (5)
[Chemical Formula 1]
Wherein the eriodictyol is 0.000001 to 1 wt% of the total weight of the cosmetic composition.
A cosmetic composition for enhancing skin moisturizing or skin elasticity, wherein the eriodictyol is 0.00005 to 0.01 wt% of the total weight of the cosmetic composition.
A cosmetic composition for skin moisturizing or skin elasticity enhancement characterized in that the eriodictyol is 0.00001 to 0.001% by weight of the total cosmetic composition.
The composition of the cosmetic composition may include at least one of a skin, a lotion, a cream, an essence, an emulsion, a gel, a lipstick, a cleansing foam, a cleansing cream, a cleansing water, a spray, a shampoo, a rinse, a treatment, a body cleanser, a soap, Cosmetics, cosmetics, cosmetics, cosmetics, cosmetics, cosmetics, cosmetics, cosmetics, cosmetics, cosmetics, cosmetics, cosmetics, cosmetics, cosmetics.
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| Application Number | Priority Date | Filing Date | Title |
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| KR1020120153152A KR20140083424A (en) | 2012-12-26 | 2012-12-26 | Cosmetic composition for cutis elastica or skin-moisture containing eriodictyol |
| PCT/KR2013/012018 WO2014104681A1 (en) | 2012-12-26 | 2013-12-23 | Pharmaceutical composition for preventing or treating skin disease comprising eriodictyol compound or a pharmaceutically acceptable salt thereof as an active ingredient |
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| KR1020120153152A KR20140083424A (en) | 2012-12-26 | 2012-12-26 | Cosmetic composition for cutis elastica or skin-moisture containing eriodictyol |
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| KR1020140074823A Division KR20140096009A (en) | 2014-06-19 | 2014-06-19 | Cosmetic composition for cutis elastica or skin-moisture containing eriodictyol |
| KR1020150078017A Division KR20150070068A (en) | 2015-06-02 | 2015-06-02 | Cosmetic composition for cutis elastica or skin-moisture containing eriodictyol |
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| KR20150087046A (en) * | 2014-01-21 | 2015-07-29 | 주식회사 엘지생활건강 | Serum-free medium composition for stem cell culture and methods for culturing stem cell |
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| KR20150087046A (en) * | 2014-01-21 | 2015-07-29 | 주식회사 엘지생활건강 | Serum-free medium composition for stem cell culture and methods for culturing stem cell |
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