KR20140003942A - Dental barrier membrane having good growth of soft tissues or bone tissues - Google Patents

Dental barrier membrane having good growth of soft tissues or bone tissues Download PDF

Info

Publication number
KR20140003942A
KR20140003942A KR1020120071797A KR20120071797A KR20140003942A KR 20140003942 A KR20140003942 A KR 20140003942A KR 1020120071797 A KR1020120071797 A KR 1020120071797A KR 20120071797 A KR20120071797 A KR 20120071797A KR 20140003942 A KR20140003942 A KR 20140003942A
Authority
KR
South Korea
Prior art keywords
bone
growth factor
membrane
growth
soft tissue
Prior art date
Application number
KR1020120071797A
Other languages
Korean (ko)
Inventor
허영구
Original Assignee
주식회사 네오바이오텍
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 주식회사 네오바이오텍 filed Critical 주식회사 네오바이오텍
Priority to KR1020120071797A priority Critical patent/KR20140003942A/en
Publication of KR20140003942A publication Critical patent/KR20140003942A/en

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
    • A61C8/0003—Not used, see subgroups
    • A61C8/0004—Consolidating natural teeth
    • A61C8/0006—Periodontal tissue or bone regeneration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A61F2/2846—Support means for bone substitute or for bone graft implants, e.g. membranes or plates for covering bone defects
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1875—Bone morphogenic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A61F2002/2817—Bone stimulation by chemical reactions or by osteogenic or biological products for enhancing ossification, e.g. by bone morphogenetic or morphogenic proteins [BMP] or by transforming growth factors [TGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Chemical & Material Sciences (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Transplantation (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Cardiology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Dentistry (AREA)
  • Vascular Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dental Prosthetics (AREA)
  • Materials For Medical Uses (AREA)

Abstract

A dental shielding film (100) of the present invention includes a body film (110) which forms a three-dimensional bone regeneration space around the deficient alveolar bone and a growth pattern part (130) which is formed on the surface of the body film (110) to help the growth of soft tissues or bone tissues around the body film (110). The growth pattern part (130) has various shapes and sizes including a linear type and a lattice type, and the like and is formed corresponding to the amount and shape of soft tissue cells or bone tissue cells.

Description

연조직 또는 골조직 성장이 우수한 치과용 차폐막{DENTAL BARRIER MEMBRANE HAVING GOOD GROWTH OF SOFT TISSUES OR BONE TISSUES}Dental barrier with excellent soft or bone tissue growth {DENTAL BARRIER MEMBRANE HAVING GOOD GROWTH OF SOFT TISSUES OR BONE TISSUES}

본 발명은 치과용 차폐막에 관한 것으로, 더욱 구체적으로는 주변의 연조직 또는 골조직의 성장을 좋게 할 수 있는 치과용 차폐막에 관한 것이다.The present invention relates to a dental shielding membrane, and more particularly to a dental shielding membrane that can improve the growth of the surrounding soft or bone tissue.

치과용 차폐막은 임플란트 시술 시 필요에 따라 사용되는 것으로, 치조골이 결손되었을 때 성공적인 임플란트 시술을 위하여 원하는 크기와 형태로 골구조물이 재생될 수 있게 치조골이나 잇몸 주변에 골재생공간을 만드는 데 사용되고 있다.Dental shields are used as needed during implantation, and are used to create bone regeneration spaces around the alveolar bone or gum so that bone structures can be regenerated in the desired size and shape for successful implantation when the alveolar bone is missing.

이러한 치과용 차폐막의 대표적인 예로 본 출원인이 권리를 갖고 있는 한국등록특허 제1061758호의 치과용 차폐막을 들 수 있고, 그 대표 도면이 도 1에 도시되어 있다.A representative example of such a dental shielding membrane is a dental shielding membrane of Korean Patent No. 1061758 to which the present applicant has a right, and a representative drawing thereof is shown in FIG. 1.

도 1에 도시된 바와 같이, 종래의 치과용 차폐막(10)은 결손된 치조골의 상단면에 위치하게 되고 많은 미세구멍들이 형성되는 상부(11), 상부(11)에 대해 자유롭게 구부려지게 상부(11)와 일체로 형성되고 결손된 치조골의 측면에 위치하게 되며 많은 미세구멍들이 형성되는 측부(12), 및 상부(11)와 측부(12)의 양측에 일체로 형성되고 상부(11) 및 측부(12)와 함께 결손된 치조골 주변에 원하는 입체 모양의 골재생공간을 형성하기 위해 상부(11)와 측부(12)에 대해 원하는 방향으로 자유롭게 구부려지는 다수의 고정발(13)들을 포함하고 있다.As shown in FIG. 1, the conventional dental shielding membrane 10 is positioned on the top surface of the missing alveolar bone and is freely bent to the top 11 and the top 11 where many micropores are formed. It is formed integrally with the side of the alveolar bone formed and missing, and the side portion 12 is formed with a number of micropores, and is formed integrally on both sides of the upper portion 11 and the side portion 12 and the upper portion 11 and side portion ( 12) includes a plurality of fixed feet 13 which are bent freely in a desired direction with respect to the upper portion 11 and the side portion 12 to form a bone regeneration space of the desired three-dimensional bone around the missing alveolar bone.

그러나 상술한 구성을 갖는 종래의 치과용 차폐막(10)은 원하는 크기의 공간을 쉽게 얻을 수 있으나, 차폐막을 덮고 있는 연조직이 약해져 차폐막이 노출될 우려가 있을 뿐만 아니라 골조직가 성장하는 데 시간이 많이 걸려 성공적인 임플란트 시술을 위해서는 다소 많은 기간이 요구되었다.However, the conventional dental shielding membrane 10 having the above-described configuration can easily obtain a space having a desired size, but the soft tissue covering the shielding membrane is weak and there is a risk that the shielding membrane is exposed, and it takes a long time for the bone tissue to grow successfully. Some time was required for the implant procedure.

본 발명은 상술한 종래기술의 문제점을 해결하기 위하여 창안된 것으로, 본 발명의 해결하고자 하는 과제는 치과용 차폐막의 표면에 연조직 또는 골조직의 성장을 돕기 위해 미세한 성장패턴부를 형성하거나, 표면에 연조직 또는 골조직의 성장을 돕는 성장인자를 도포하거나, 또는 성장패턴부를 형성하고 그 위에 성장인자를 도포함으로써 치과용 차폐막이 설치된 결손된 치조골 주변에 있는 연조직 또는 골조직의 성장을 좋게 할 수 있는 치과용 차폐막을 제공하는 것이다.The present invention has been made to solve the above-described problems of the prior art, the problem to be solved of the present invention is to form a fine growth pattern portion to help the growth of soft or bone tissue on the surface of the dental shielding membrane, or the soft tissue or By providing a growth factor to help the growth of bone tissue, or by forming a growth pattern and applying a growth factor thereon, it provides a dental shielding membrane that can improve the growth of soft or bone tissue around the missing alveolar bone with a dental shielding membrane installed thereon. It is.

상술한 본 발명의 과제를 달성하기 위하여, 본 발명은 제1실시예에서 결손된 치조골 주변에 원하는 입체 모양의 골재생공간을 형성하는 본체막과, 상기 본체막 주변의 연조직 또는 골조직의 성장을 돕기 위해 상기 본체막의 표면에 형성되는 성장패턴부를 포함하는 것을 특징으로 하는 연조직 또는 골조직 성장이 우수한 치과용 차폐막을 제공한다.In order to achieve the above object of the present invention, the present invention is to support the growth of the main body film and the soft tissue or bone tissue around the main body film to form a bone regeneration space of the desired three-dimensional bone around the missing alveolar bone in the first embodiment To provide a dental shielding film excellent in soft tissue or bone tissue growth, characterized in that it comprises a growth pattern portion formed on the surface of the body film.

본 실시예에서, 상기 성장패턴부는 일자 형상, 격자 형상 등의 다양한 형상과 크기를 갖고, 연조직 또는 골조직 세포의 양과 형태에 맞게 형성되는 것을 특징으로 한다.In this embodiment, the growth pattern portion has a variety of shapes and sizes, such as a straight line, lattice shape, characterized in that formed in accordance with the amount and shape of soft tissue or bone tissue cells.

본 발명은 제2실시예에서 결손된 치조골 주변에 원하는 입체 모양의 골재생공간을 형성하는 본체막과, 상기 본체막 주변의 연조직 또는 골조직의 성장을 돕기 위해 상기 본체막의 표면에 성장인자도포막이 형성되는 것을 특징으로 하는 연조직 또는 골조직 성장이 우수한 치과용 차폐막을 제공한다.The present invention provides a body film for forming a desired three-dimensional bone regeneration space around the missing alveolar bone, and a growth factor coating film is formed on the surface of the body film to assist the growth of soft or bone tissue around the body film. It provides a dental shielding membrane excellent in soft tissue or bone tissue growth, characterized in that.

본 실시예에서, 상기 성장인자도포막은 상기 본체막의 한면에 연조직성장인자가 도포되거나, 상기 본체막의 한면에 골조직성장인자가 도포되거나, 또는 상기 본체막의 한면에는 연조직성장인자가 도포되고 다른면에는 골조직성장인자가 도포되는 것을 특징으로 하고, 상기 연조직성장인자의 도포는 상기 본체막의 표면에 도파민을 접착제로 하여 히알루론산셀을 접착하고 상기 히알루론산셀에 연조직세포성장인자를 담지시켜서 이루어지고, 상기 골조직성장인자의 도포는 상기 본체막의 표면에 도파민을 접착제로 하여 히알루론산셀을 접착하고 상기 히알루론산셀에 재조합골형성단백질을 담지시켜서 이루어지는 것을 다른 특징으로 한다.In the present embodiment, the growth factor coating layer may be coated with a soft tissue growth factor on one side of the body membrane, a bone tissue growth factor on one side of the body membrane, or a soft tissue growth factor on one side of the body membrane and a bone tissue on the other side. Characterized in that the growth factor is applied, the application of the soft tissue growth factor is made by adhering the hyaluronic acid cell with dopamine as an adhesive on the surface of the body membrane and supporting the soft tissue cell growth factor on the hyaluronic acid cell, the bone tissue Application of the growth factor is characterized in that the hyaluronic acid cell is adhered to the surface of the main body membrane using dopamine as an adhesive and the recombinant bone forming protein is supported on the hyaluronic acid cell.

본 발명은 제3실시예에서 결손된 치조골 주변에 원하는 입체 모양의 골재생공간을 형성하는 본체막과, 상기 본체막 주변의 연조직 또는 골조직의 성장을 돕기 위해 상기 본체막의 표면에 형성되는 성장패턴부와, 상기 결손된 치조골 주변의 연조직 또는 골조직의 성장을 돕기 위해 상기 성장패턴부가 형성된 상기 본체막 표면에 형성되는 성장인자도포막을 포함하는 것을 특징으로 하는 연조직 또는 골조직 성장이 우수한 치과용 차폐막을 제공한다.The present invention is a body film forming a bone regeneration space of the desired three-dimensional shape around the missing alveolar bone in the third embodiment, and the growth pattern portion formed on the surface of the body film to help the growth of soft or bone tissue around the body film And a growth factor coating film formed on the surface of the main body film in which the growth pattern portion is formed to assist the growth of the soft tissue or the bone tissue around the defective alveolar bone. .

본 실시예에서, 상기 성장패턴부는 일자 형상, 격자 형상 등의 다양한 형상과 크기를 갖고, 연조직 또는 골조직 세포의 양과 형태에 맞게 형성되는 것과, 또한 상기 성장인자도포막은 상기 본체막의 한면에 연조직성장인자가 도포되거나, 상기 본체막의 한면에 골조직성장인자가 도포되거나, 또는 상기 본체막의 한면에는 연조직성장인자가 도포되고 다른면에는 골조직성장인자가 도포되는 것을 특징으로 하고, 상기 연조직성장인자의 도포는 상기 본체막의 표면에 도파민을 접착제로 하여 히알루론산셀을 접착하고 상기 히알루론산셀에 연조직세포성장인자를 담지시켜서 이루어지고, 상기 골조직성장인자의 도포는 상기 본체막의 표면에 도파민을 접착제로 하여 히알루론산셀을 접착하고 상기 히알루론산셀에 재조합골형성단백질을 담지시켜서 이루어지는 것을 다른 특징으로 한다.In the present embodiment, the growth pattern portion has a variety of shapes and sizes, such as a straight line, lattice, and the like is formed in accordance with the amount and shape of soft tissue or bone tissue cells, the growth factor coating film is a soft tissue growth factor on one side of the body membrane Is applied, or bone tissue growth factor is applied to one side of the main body membrane, or soft tissue growth factor is applied to one side of the main body membrane and bone tissue growth factor is applied to the other side, the application of the soft tissue growth factor is The hyaluronic acid cell is adhered to the surface of the main body membrane with dopamine as an adhesive and the soft tissue cell growth factor is supported on the hyaluronic acid cell.The bone tissue growth factor is coated on the surface of the main body membrane with dopamine as the adhesive. By adhering the recombinant bone-forming protein to the hyaluronic acid cell And that eojineun with other features.

본 발명은 또한 본체막이 티타늄으로 만들어지는 것을 특징으로 한다.The present invention is also characterized in that the body film is made of titanium.

본 발명의 치과용 차폐막은 표면에 미세한 성장패턴부가 형성되거나, 연조직 또는 골조직의 성장을 돕는 성장인자가 도포되거나, 또는 성장패턴부가 형성되고 그 위에 성장인자가 도포되기 때문에 치과용 차폐막이 설치된 결손된 치조골 주변에 있는 연조직 또는 골조직의 성장을 좋게 할 수 있고 이로 인해 성공적인 임플란트 시술에 필요한 기간을 크게 줄일 수 있다.In the dental shielding film of the present invention, a fine growth pattern portion is formed on the surface, a growth factor to help the growth of soft tissue or bone tissue is applied, or a growth pattern portion is formed and a growth factor is applied thereon so that the dental shielding film is provided with a defect. The growth of soft or bone tissue around the alveolar bone can be improved, thereby significantly reducing the time required for successful implantation.

도 1은 종래의 치과용 차폐막의 개략적인 사시도;
도 2는 본 발명의 바람직한 제1실시예에 따른 치과용 차폐막의 개략도;
도 3은 본 발명의 바람직한 제2실시예에 따른 치과용 차폐막의 개략도; 및
도 4는 본 발명의 바람직한 제3실시예에 따른 치과용 차폐막의 개략도이다.1 is a schematic perspective view of a conventional dental shield;
2 is a schematic view of a dental shielding membrane according to a first preferred embodiment of the present invention;
3 is a schematic view of a dental shielding membrane according to a second preferred embodiment of the present invention; And
4 is a schematic diagram of a dental shielding membrane according to a third preferred embodiment of the present invention.

이하, 첨부한 도면을 참조로 본 발명의 바람직한 실시예들에 따른 치과용 차폐막에 대하여 상세하게 설명한다.Hereinafter, with reference to the accompanying drawings will be described in detail with respect to the dental shielding film according to the preferred embodiments of the present invention.

제1실시예First Embodiment

도 2는 본 발명의 바람직한 제1실시예에 따른 치과용 차폐막의 개략도이다.2 is a schematic diagram of a dental shielding membrane according to a first preferred embodiment of the present invention.

도 2에 도시한 바와 같이, 본 실시예에 따른 치과용 차폐막(100)은 본체막(110) 및 성장패턴부(130)를 포함하고 있다.As shown in FIG. 2, the dental shielding film 100 according to the present embodiment includes a body film 110 and a growth pattern part 130.

본체막(110)은 티타늄 재질로 박판 형태로 만들어지고, 결손된 치조골의 상단면에 위치하게 되고 많은 미세구멍들이 형성되는 상부(111), 상부(111)에 대해 자유롭게 구부려지게 상부(111)와 일체로 형성되고 결손된 치조골의 측면에 위치하게 되며 많은 미세구멍들이 형성되는 측부(113), 및 상부(111)와 측부(113)의 양측에 일체로 형성되고 상부(111) 및 측부(113)와 함께 결손된 치조골 주변에 원하는 입체 모양의 골재생공간을 형성하기 위해 상부(111)와 측부(113)에 대해 원하는 방향으로 자유롭게 구부려지는 다수의 고정발(115)들을 포함한다.Body film 110 is made of a thin plate made of titanium material, is located on the upper surface of the missing alveolar bone and the upper portion 111 and the upper portion 111 to be bent freely to the upper portion 111, the upper portion 111 is formed The side portion 113 is formed integrally formed and is located on the side of the missing alveolar bone, and the upper side 111 and the side portion 113 are integrally formed on both sides of the upper portion 111 and the side portion 113. And a plurality of fixing feet 115 which are bent freely in a desired direction with respect to the upper portion 111 and the side portion 113 to form a desired three-dimensional bone regeneration space around the alveolar bone.

성장패턴부(130)는 결손된 치조골 주변의 연조직 또는 골조직의 성장을 돕기 위해 본체막(110)의 한면 또는 양면에 미세한 크기로 형성된다. 도 2는 본체막(110)의 양면에 성장패턴부(130)가 형성된 상태를 예시적으로 나타낸 도면이다.The growth pattern 130 is formed to have a fine size on one or both sides of the body film 110 to help the growth of the soft tissue or bone tissue around the missing alveolar bone. 2 is a diagram illustrating a state in which the growth pattern 130 is formed on both surfaces of the body film 110.

성장패턴부(130)의 형성은, (1) 본체막(110) 표면에 감광막을 도포하는 공정, (2) 감광막이 도포된 본체막(110) 위에 원하는 형상의 패턴이 형성된 마스크를 적층하는 공정, (3) 마스크가 적층된 본체막(110)에 자외선을 조사시켜 패턴 형상에 맞게 감광막을 열화시킨 후 마스크를 제거하는 공정, (4) 마스크가 제거된 본체막(110)을 현상하여 감광막의 열화된 부위를 제거하는 공정, (5) 불산 식각액을 사용하여 감광막의 열화된 패턴 형상의 부위에 해당하는 본체막(110)을 식각하여 본체막(110)에 원하는 패턴 형상을 형성하는 공정 및 (6) 감광막을 제거하는 공정으로 이루어진다.The growth pattern 130 is formed by (1) applying a photoresist film to the surface of the main body film 110 and (2) laminating a mask having a pattern having a desired shape on the main body film 110 to which the photosensitive film is applied. (3) irradiating ultraviolet rays to the body film 110 on which the mask is laminated to deteriorate the photoresist film according to the pattern shape, and then removing the mask. (4) developing the body film 110 from which the mask is removed to develop the photoresist film. (5) forming a desired pattern shape on the main body film 110 by etching the main body film 110 corresponding to the deteriorated pattern shape of the photosensitive film using a hydrofluoric acid etchant; 6) It consists of a process of removing a photosensitive film.

성장패턴부(130)를 형성하는 공정은 일반적으로 반도체 제조공정에서 반도체 표면에 회로패턴을 형성하는 공정과 유사하므로 이에 대한 구체적인 설명은 생략한다.Since the process of forming the growth pattern unit 130 is generally similar to the process of forming a circuit pattern on the surface of the semiconductor in the semiconductor manufacturing process, a detailed description thereof will be omitted.

본체막(110)의 표면에 이와 같이 성장패턴부(130)를 형성하게 되면, 연조직 또는 골조직 세포의 분화 및 증식을 높임과 동시에 방향성을 높여 연조직 또는 골조직의 성장을 돕게 된다. 성장패턴부(130)는 일자 형상, 격자 형상 등의 다양한 형상과 크기로 형성될 수 있는 데, 그 형상과 크기에 따라 연조직 또는 골조직 세포의 양과 형태가 변하게 된다. When the growth pattern 130 is formed on the surface of the main body film 110 as described above, the differentiation and proliferation of the soft tissues or the bone tissues is increased, and the direction is increased to assist the growth of the soft tissues or the bone tissues. The growth pattern unit 130 may be formed in various shapes and sizes, such as a straight shape and a lattice shape, and the amount and shape of soft tissue or bone tissue cells change according to the shape and size.

제2실시예Second Embodiment

도 3은 본 발명의 바람직한 제2실시예에 따른 치과용 차폐막의 개략도이다.3 is a schematic view of a dental shielding membrane according to a second preferred embodiment of the present invention.

도 3에 도시한 바와 같이, 본 실시예에 따른 치과용 차폐막(200)은 본체막(210) 및 성장인자도포막(230)을 포함하고 있다.As shown in FIG. 3, the dental shielding film 200 according to the present embodiment includes a main body film 210 and a growth factor coating film 230.

본체막(210)은 티타늄 재질로 박판 형태로 만들어지고, 결손된 치조골의 상단면에 위치하게 되고 많은 미세구멍들이 형성되는 상부(211), 상부(211)에 대해 자유롭게 구부려지게 상부(211)와 일체로 형성되고 결손된 치조골의 측면에 위치하게 되며 많은 미세구멍들이 형성되는 측부(213), 및 상부(211)와 측부(213)의 양측에 일체로 형성되고 상부(211) 및 측부(213)와 함께 결손된 치조골 주변에 원하는 입체 모양의 골재생공간을 형성하기 위해 상부(211)와 측부(213)에 대해 원하는 방향으로 자유롭게 구부려지는 다수의 고정발(215)들을 포함한다.Body film 210 is made of a thin plate made of titanium material, is located on the top surface of the missing alveolar bone and the upper 211 and the upper 211 to be bent freely with respect to the upper portion 211, the upper portion 211 is formed The side portion 213 is formed integrally formed and located on the side of the missing alveolar bone and is formed integrally on both sides of the upper portion 211 and the side portion 213 and the upper portion 211 and the side portion 213. And a plurality of fixing feet 215 that are freely bent in a desired direction with respect to the upper portion 211 and the side portion 213 to form a bone regeneration space of a desired three-dimensional shape around the missing alveolar bone.

성장인자도포막(230)은 결손된 치조골 주변의 연조직 또는 골조직의 성장을 돕기 위해 본체막(210)의 한면 또는 양면에 형성된다. 구체적으로, 성장인자도포막(230)은 연조직의 성장을 돕기 위해 본체막(210)의 한면에 연조직성장인자가 도포되거나, 골조직의 성장을 돕기 위해 본체막(210)의 한면에 골조직성장인자가 도포되거나, 또는 연조직과 골조직의 성장을 동시에 돕기 위해 본체막(210)의 한면에는 연조직성장인자가 도포되고 다른면에는 골조직성장인자가 도포될 수 있다. 도 3은 본체막(210)의 한면에는 연조직성장인자(231)가 도포되고 다른면에는 골조직성장인자(233)가 도포된 상태를 예시적으로 나타낸 도면이다.The growth factor coating layer 230 is formed on one or both sides of the body membrane 210 to help growth of soft or bone tissue around the defective alveolar bone. Specifically, the growth factor coating film 230 is a soft tissue growth factor is applied to one side of the body membrane 210 to help the soft tissue growth, or bone tissue growth factor on one side of the body membrane 210 to help the growth of bone tissue Alternatively, the soft tissue growth factor may be applied to one side of the body membrane 210 and the bone tissue growth factor may be applied to the other side to assist the growth of the soft tissue and the bone tissue at the same time. 3 is a diagram illustrating a state in which a soft tissue growth factor 231 is applied to one surface of the body film 210 and a bone tissue growth factor 233 is applied to the other surface thereof.

성장인자도포막(230)은 본체막(210)의 표면에 도파민(또는 도파)을 접착제로 하여 히알루론산셀(Hyaluronic acid shell)을 접착하고 여기에 연조직세포성장인자(Epidermal Growth Factor, EGF)를 담지시키거나, 재조합골형성단백질(Recombinant Human Bone Morphogenetic Protein: rhBMP2)을 담지시킴으로써 연조직성장인자도포막이 형성되거나 또는 골조직성장인자도포막이 형성되게 된다.The growth factor coating film 230 adheres hyaluronic acid shell to the surface of the main body film 210 using dopamine (or waveguide) as an adhesive, and attaches a soft tissue growth factor (EGF) to the hyaluronic acid shell. By supporting or supporting the recombinant human Bone Morphogenetic Protein (rhBMP2), a soft tissue growth factor coating film or a bone tissue growth factor coating film is formed.

본체막(210)의 표면에 이와 같이 성장인자도포막(230)을 형성하게 되면, 연조직 또는 골조직 세포의 분화 및 증식을 높여 연조직 또는 골조직의 성장을 돕게 된다.When the growth factor coating layer 230 is formed on the surface of the body membrane 210, the differentiation and proliferation of soft tissues or bone tissue cells may be increased to help soft tissues or bone tissues grow.

제3실시예Third Embodiment

도 4는 본 발명의 바람직한 제3실시예에 따른 치과용 차폐막의 개략도이다.4 is a schematic diagram of a dental shielding membrane according to a third preferred embodiment of the present invention.

도 4에 도시한 바와 같이, 본 실시예에 따른 치과용 차폐막(300)은 본체막(310), 성장패턴부(330) 및 성장인자도포막(350)을 포함하고 있다.As shown in FIG. 4, the dental shielding film 300 according to the present embodiment includes a main body film 310, a growth pattern portion 330, and a growth factor coating film 350.

본체막(310)은 티타늄 재질로 박판 형태로 만들어지고, 결손된 치조골의 상단면에 위치하게 되고 많은 미세구멍들이 형성되는 상부(311), 상부(311)에 대해 자유롭게 구부려지게 상부(311)와 일체로 형성되고 결손된 치조골의 측면에 위치하게 되며 많은 미세구멍들이 형성되는 측부(313), 및 상부(311)와 측부(313)의 양측에 일체로 형성되고 상부(311) 및 측부(313)와 함께 결손된 치조골 주변에 원하는 입체 모양의 골재생공간을 형성하기 위해 상부(311)와 측부(313)에 대해 원하는 방향으로 자유롭게 구부려지는 다수의 고정발(315)들을 포함한다.Body film 310 is made of a thin plate made of titanium material, is located on the upper surface of the missing alveolar bone and the upper 311 and the upper 311 to be bent freely to the upper portion 311, the upper portion 311 is formed The side portion 313 is formed integrally formed and located on the side of the missing alveolar bone, and formed in both sides of the upper portion 311 and the side portion 313 and the upper portion 311 and side portion 313 And a plurality of fixation feet 315 which are bent freely in a desired direction with respect to the upper portion 311 and the side portion 313 to form a bone regeneration space of a desired three-dimensional shape around the missing alveolar bone.

성장패턴부(330)는 결손된 치조골 주변의 연조직 또는 골조직의 성장을 돕기 위해 본체막(310)의 한면 또는 양면에 형성된다. 성장패턴부(330)는 앞서 설명한 제1실시예의 성장패턴부(130)와 형성 방법 및 형상 등의 같기 때문에 설명의 중복을 피하기 위하여 이에 대한 구체적인 설명은 생략한다.The growth pattern part 330 is formed on one side or both sides of the body film 310 to help growth of soft tissue or bone tissue around the missing alveolar bone. Since the growth pattern unit 330 is the same as the growth pattern unit 130 of the first embodiment as described above, and the formation method and shape thereof, detailed description thereof will be omitted in order to avoid duplication of description.

성장인자도포막(350)은 결손된 치조골 주변의 연조직 또는 골조직의 성장을 돕기 위해 성장패턴부(330)가 형성된 본체막(310)에 형성된다. 구체적으로, 성장인자도포막(330)은 연조직의 성장을 돕기 위해 본체막(310)의 한면에 연조직성장인자가 도포되거나, 골조직의 성장을 돕기 위해 본체막(310)의 한면에 골조직성장인자가 도포되거나, 또는 연조직과 골조직의 성장을 동시에 돕기 위해 본체막(310)의 한면에는 연조직성장인자가 도포되고 다른면에는 골조직성장인자가 도포될 수 있다. 성장인자도포막(350)의 형성은 앞서 설명한 제2실시예의 성장인자도포막(230)의 형성과 같기 때문에 설명의 중복을 피하기 위하여 이에 대한 구체적인 설명은 생략한다. 도 4는 본체막(310)의 양면에 성장패턴부(310)가 형성되고, 한면에는 연조직성장인자(351)가 도포되고 다른면에는 골조직성장인자(353)가 도포된 상태를 예시적으로 나타낸 도면이다.The growth factor coating film 350 is formed on the body film 310 in which the growth pattern part 330 is formed to help the soft tissue or the bone tissue around the missing alveolar bone grow. Specifically, the growth factor coating film 330 may be a soft tissue growth factor applied to one side of the body membrane 310 to help the soft tissue growth, or a bone tissue growth factor on one side of the body membrane 310 to help the growth of the bone tissue. Alternatively, soft tissue growth factor may be applied to one side of the main body membrane 310 and bone tissue growth factor to the other side in order to simultaneously support soft tissue and bone tissue growth. Since the formation of the growth factor coating film 350 is the same as the formation of the growth factor coating film 230 of the second embodiment, detailed description thereof will be omitted in order to avoid duplication of explanation. 4 illustrates a state in which the growth pattern part 310 is formed on both surfaces of the main body film 310, the soft tissue growth factor 351 is applied to one side, and the bone tissue growth factor 353 is applied to the other side. Drawing.

본 실시예와 같이, 본체막(310)에 성장패턴부(330)를 형성하고 그 위에 성장인자도포막(350)을 형성하게 되면, 앞서 제1실시예와 같이 성장패턴부(130)만 형성하거나 제2실시예와 같이 성장인자도포막(230)만을 형성한 경우 보다 연조직 또는 골조직의 성장을 훨씬 빠르고 우수하게 진행시킬 수 있다.As in the present embodiment, when the growth pattern portion 330 is formed on the main body film 310 and the growth factor coating layer 350 is formed thereon, only the growth pattern portion 130 is formed as in the first embodiment. Or, as in the case of forming only the growth factor coating film 230 as in the second embodiment, the growth of soft tissue or bone tissue can be much faster and better.

이상 본 발명의 바람직한 여러 실시예들을 참고로 치과용 차폐막에 대하여 설명하였지만, 본 발명의 사상을 벗어나지 않는 범위 안에서 다양한 변경, 변형 또는 수정이 가능함은 당업자에게 명백하다.While the dental shielding film has been described with reference to various preferred embodiments of the present invention, it is apparent to those skilled in the art that various changes, modifications, or modifications can be made without departing from the spirit of the present invention.

100,200,300 : 치과용 차폐막 110,210,310 : 본체막
130,330 : 성장패턴부 230,350 : 성장인자도포막100,200,300: Dental shielding film 110,210,310: Body film
130,330: growth pattern portion 230,350: growth factor coating film

Claims (10)

결손된 치조골 주변에 원하는 입체 모양의 골재생공간을 형성하는 본체막; 및
상기 본체막 주변의 연조직 또는 골조직의 성장을 돕기 위해 상기 본체막의 표면에 형성되는 성장패턴부를 포함하는 것을 특징으로 하는 연조직 또는 골조직 성장이 우수한 치과용 차폐막.Body film to form a bone regeneration space of the desired three-dimensional shape around the missing alveolar bone; And
Dental shielding membrane excellent in soft tissue or bone tissue growth, characterized in that it comprises a growth pattern portion formed on the surface of the main body film to help the growth of soft tissue or bone tissue around the body membrane. 제1항에 있어서, 상기 성장패턴부는 일자 형상, 격자 형상 등의 다양한 형상과 크기를 갖고, 연조직 또는 골조직 세포의 양과 형태에 맞게 형성되는 것을 특징으로 하는 치과용 차폐막.The dental shielding membrane of claim 1, wherein the growth pattern part has various shapes and sizes, such as a straight shape and a lattice shape, and is formed in accordance with the amount and shape of soft tissue or bone tissue cells. 결손된 치조골 주변에 원하는 입체 모양의 골재생공간을 형성하는 본체막; 및
상기 본체막 주변의 연조직 또는 골조직의 성장을 돕기 위해 상기 본체막의 표면에 성장인자도포막이 형성되는 것을 특징으로 하는 연조직 또는 골조직 성장이 우수한 치과용 차폐막.Body film to form a bone regeneration space of the desired three-dimensional shape around the missing alveolar bone; And
Dental barrier film excellent in soft tissue or bone tissue growth, characterized in that the growth factor coating film is formed on the surface of the main body membrane to help the growth of soft tissue or bone tissue around the body membrane. 제3항에 있어서, 상기 성장인자도포막은 상기 본체막의 한면에 연조직성장인자가 도포되거나, 상기 본체막의 한면에 골조직성장인자가 도포되거나, 또는 상기 본체막의 한면에는 연조직성장인자가 도포되고 다른면에는 골조직성장인자가 도포되는 것을 특징으로 하는 치과용 차폐막.According to claim 3, wherein the growth factor coating film is applied to the soft tissue growth factor on one side of the main body film, the bone tissue growth factor is applied to one side of the body membrane, or the soft tissue growth factor is applied to one side of the main body film and the other side Dental shielding membrane, characterized in that the bone tissue growth factor is applied. 제4항에 있어서, 상기 연조직성장인자의 도포는 상기 본체막의 표면에 도파민을 접착제로 하여 히알루론산셀을 접착하고 상기 히알루론산셀에 연조직세포성장인자를 담지시켜서 이루어지고, 상기 골조직성장인자의 도포는 상기 본체막의 표면에 도파민을 접착제로 하여 히알루론산셀을 접착하고 상기 히알루론산셀에 재조합골형성단백질을 담지시켜서 이루어지는 것을 특징으로 하는 치과용 차폐막.The method according to claim 4, wherein the soft tissue growth factor is applied to the surface of the body membrane by adhering dopamine as an adhesive to hyaluronic acid cells and supporting the soft tissue cell growth factor on the hyaluronic acid cells, and applying the bone tissue growth factor. The dental shielding membrane is formed by adhering a hyaluronic acid cell with a dopamine as an adhesive on the surface of the main body membrane and carrying a recombinant bone forming protein on the hyaluronic acid cell. 결손된 치조골 주변에 원하는 입체 모양의 골재생공간을 형성하는 본체막;
상기 본체막 주변의 연조직 또는 골조직의 성장을 돕기 위해 상기 본체막의 표면에 형성되는 성장패턴부; 및
상기 본체막 주변의 연조직 또는 골조직의 성장을 돕기 위해 상기 성장패턴부가 형성된 상기 본체막 표면에 형성되는 성장인자도포막을 포함하는 것을 특징으로 하는 연조직 또는 골조직 성장이 우수한 치과용 차폐막.Body film to form a bone regeneration space of the desired three-dimensional shape around the missing alveolar bone;
A growth pattern part formed on a surface of the main body film to help growth of soft or bone tissue around the main body film; And
Dental barrier membrane excellent in soft tissue or bone tissue growth, characterized in that it comprises a growth factor coating film formed on the surface of the main body film formed with the growth pattern portion to help the growth of soft tissue or bone tissue around the main membrane. 제6항에 있어서, 상기 성장패턴부는 일자 형상, 격자 형상 등의 다양한 형상과 크기를 갖고, 연조직 또는 골조직 세포의 양과 형태에 맞게 형성되는 것을 특징으로 하는 치과용 차폐막.The dental shielding membrane of claim 6, wherein the growth pattern part has various shapes and sizes, such as a straight shape and a lattice shape, and is formed in accordance with the amount and shape of soft tissue or bone tissue cells. 제6항에 있어서, 상기 성장인자도포막은 상기 본체막의 한면에 연조직성장인자가 도포되거나, 상기 본체막의 한면에 골조직성장인자가 도포되거나, 또는 상기 본체막의 한면에는 연조직성장인자가 도포되고 다른면에는 골조직성장인자가 도포되는 것을 특징으로 하는 치과용 차폐막.According to claim 6, wherein the growth factor coating layer is applied to the soft tissue growth factor on one side of the main body film, bone tissue growth factor is applied to one side of the body membrane, or one side of the body membrane is applied to the soft tissue growth factor and the other side Dental shielding membrane, characterized in that the bone tissue growth factor is applied. 제8항에 있어서, 상기 연조직성장인자의 도포는 상기 본체막의 표면에 도파민을 접착제로 하여 히알루론산셀을 접착하고 상기 히알루론산셀에 연조직세포성장인자를 담지시켜서 이루어지고, 상기 골조직성장인자의 도포는 상기 본체막의 표면에 도파민을 접착제로 하여 히알루론산셀을 접착하고 상기 히알루론산셀에 재조합골형성단백질을 담지시켜서 이루어지는 것을 특징으로 하는 치과용 차폐막.The method of claim 8, wherein the application of the soft tissue growth factor is made by adhering the hyaluronic acid cell with dopamine as an adhesive on the surface of the main body membrane and supporting the soft tissue cell growth factor on the hyaluronic acid cell, the application of the bone tissue growth factor The dental shielding membrane is formed by adhering a hyaluronic acid cell with a dopamine as an adhesive on the surface of the main body membrane and carrying a recombinant bone forming protein on the hyaluronic acid cell. 제1항 내지 제9항 중 어느 한 항에 있어서, 상기 본체막은 티타늄으로 만들어지는 것을 특징으로 하는 치과용 차폐막.10. The dental shield membrane according to any one of claims 1 to 9, wherein the body membrane is made of titanium.
KR1020120071797A 2012-07-02 2012-07-02 Dental barrier membrane having good growth of soft tissues or bone tissues KR20140003942A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020120071797A KR20140003942A (en) 2012-07-02 2012-07-02 Dental barrier membrane having good growth of soft tissues or bone tissues

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1020120071797A KR20140003942A (en) 2012-07-02 2012-07-02 Dental barrier membrane having good growth of soft tissues or bone tissues

Publications (1)

Publication Number Publication Date
KR20140003942A true KR20140003942A (en) 2014-01-10

Family

ID=50140210

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020120071797A KR20140003942A (en) 2012-07-02 2012-07-02 Dental barrier membrane having good growth of soft tissues or bone tissues

Country Status (1)

Country Link
KR (1) KR20140003942A (en)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20160069949A (en) * 2014-12-09 2016-06-17 오스템임플란트 주식회사 Membrane for guided bone regeneration and method of manufacturing thereof
KR20160091195A (en) * 2015-01-23 2016-08-02 오스템임플란트 주식회사 A resorbable guided bone regeneration membrane and an ampoule for storing the same
CN106122679A (en) * 2016-08-16 2016-11-16 江苏迪威高压科技股份有限公司 A kind of petroleum pipe fitting of band protective cover
WO2017069366A1 (en) 2015-10-21 2017-04-27 Republic Of Korea(Management : Rural Development Administration) Dental barrier membrane using silk matrix and method of manufacturing the same
US10525165B2 (en) 2014-08-04 2020-01-07 Republic Of Korea (Management: Rural Development Administration) Dental barrier membrane using cocoon and method for manufacturing same
WO2020138779A1 (en) * 2018-12-28 2020-07-02 오스템임플란트 주식회사 Method for manufacturing alveolar bone regeneration membrane
CN113750296A (en) * 2021-10-21 2021-12-07 湖南华耀百奥医疗科技有限公司 Hyaluronic acid coating zinc alloy barrier repair film and preparation method thereof

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10525165B2 (en) 2014-08-04 2020-01-07 Republic Of Korea (Management: Rural Development Administration) Dental barrier membrane using cocoon and method for manufacturing same
KR20160069949A (en) * 2014-12-09 2016-06-17 오스템임플란트 주식회사 Membrane for guided bone regeneration and method of manufacturing thereof
KR20160091195A (en) * 2015-01-23 2016-08-02 오스템임플란트 주식회사 A resorbable guided bone regeneration membrane and an ampoule for storing the same
WO2017069366A1 (en) 2015-10-21 2017-04-27 Republic Of Korea(Management : Rural Development Administration) Dental barrier membrane using silk matrix and method of manufacturing the same
CN107708602A (en) * 2015-10-21 2018-02-16 大韩民国（农村振兴厅长） Use the dentistry barrier film and its manufacture method of silk matrix
US10786335B2 (en) 2015-10-21 2020-09-29 Republic Of Korea (Management: Rural Development Administration) Dental barrier membrane using silk matrix and method of manufacturing the same
CN106122679A (en) * 2016-08-16 2016-11-16 江苏迪威高压科技股份有限公司 A kind of petroleum pipe fitting of band protective cover
WO2020138779A1 (en) * 2018-12-28 2020-07-02 오스템임플란트 주식회사 Method for manufacturing alveolar bone regeneration membrane
CN113750296A (en) * 2021-10-21 2021-12-07 湖南华耀百奥医疗科技有限公司 Hyaluronic acid coating zinc alloy barrier repair film and preparation method thereof

Similar Documents

Publication Publication Date Title
KR20140003942A (en) Dental barrier membrane having good growth of soft tissues or bone tissues
US10882221B2 (en) Peeling method of flexible substrate
DE602004019938D1 (en) COATED IMPLANTS AND COATING PROCESS
KR20180030883A (en) Calibration technology in haptic systems
JPH03209479A (en) Exposure method
CN104102094A (en) Mask baffle plate and fabrication method thereof
DE60326802D1 (en) Method for producing a transparent oxide electrode layer
CN101995762A (en) Mask and preparation method thereof
TW201211675A (en) A photomask unit comprising a photomask and a pellicle attached to the photomask and a method for fabricating a photomask unit
CN105093807A (en) Mask plate, fabrication method thereof and exposure system
TW200505617A (en) Method and apparatus for removing an edge region of a layer applied to a substrate and for coating a substrate and a substrate
SE0303169D0 (en) Fixation system for implant elements
JP2006235208A (en) Lens cover
US20200069427A1 (en) Bone implant for the reconstruction of an osseous defect and for guiding a marking and/or processing tool for transferring required osteotomy situations
McHugh et al. A novel porous scaffold fabrication technique for epithelial and endothelial tissue engineering
CN109032414A (en) The preparation method of display panel and display panel
CN105097859B (en) By the system and method for camera cube black coating on wafer layer
JPS62134604A (en) Formation for color filter film
KR101061758B1 (en) Dental barrier membrane
US20160067387A1 (en) Amorphous Silicon Oxide, Amorphous Silicon Oxynitride, and Amorphous Silicon Nitride Thin Films and Uses Thereof
JP2015506734A (en) Patch structure for controlling wound healing
TW200842509A (en) Hybrid mask and method of forming same
KR101804478B1 (en) Digital exposure apparatus and method of exposing substrate using the same
JP2009231324A (en) Stencil mask and method of manufacturing the same
CN209734234U (en) Titanium mesh implant for personalized alveolar bone increment generated by applying three-dimensional printing technology

Legal Events

Date Code Title Description
E902 Notification of reason for refusal
E601 Decision to refuse application