KR20110051162A - Composition for immune enhancement comprising the extract of young antler, cornus officinalis, ligusticum acutilobum, aurantii nobilis pericarpium, chinese matrimony vine, lotus root, yam, curcuma aromatica salisb, gastrodia elata blume, agastache rugosa, cinnamomum loureirii, ginseng steamed red and schizandra chinensis, as active ingredient - Google Patents
Composition for immune enhancement comprising the extract of young antler, cornus officinalis, ligusticum acutilobum, aurantii nobilis pericarpium, chinese matrimony vine, lotus root, yam, curcuma aromatica salisb, gastrodia elata blume, agastache rugosa, cinnamomum loureirii, ginseng steamed red and schizandra chinensis, as active ingredient Download PDFInfo
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- KR20110051162A KR20110051162A KR1020100111203A KR20100111203A KR20110051162A KR 20110051162 A KR20110051162 A KR 20110051162A KR 1020100111203 A KR1020100111203 A KR 1020100111203A KR 20100111203 A KR20100111203 A KR 20100111203A KR 20110051162 A KR20110051162 A KR 20110051162A
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- lotus root
- active ingredient
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Abstract
Description
본 발명은 한약재를 주재료로 하는 면역증강용 조성물에 관한 것으로, 더욱 상세하게는 녹용, 산수유, 당귀, 진피, 구기자, 연근, 산약, 울금, 천마, 배초향, 계피, 복분자, 오미자 및 홍삼의 생약 추출물을 적정 성분비로 포함하여 면역증강, 피로회복 및 성기능 항진 등의 공진단과 유사한 약리활성을 나타내 사향이 제거된 가미공진단 제조에 이용하거나, 면역증강 및 피로회복을 위한 약학적 제제 또는 건강기능식품으로 이용가능한 면역증강용 조성물에 관한 것이다.
The present invention relates to a composition for immuno-enhancement, the main ingredient of the herbal medicine, more specifically, medicinal extracts of deer antler, cornus, donkey, dermis, goji berry, lotus root, medicinal herb, turmeric, cheonma, baecho fragrance, cinnamon, bokbunja, Schisandra chinensis and red ginseng It is used as a pharmaceutical ingredient or health functional food for immunity enhancement and recovery of fatigue by showing the pharmacological activity similar to the resonant stage such as immunity enhancement, fatigue recovery and sexual enhancement, etc. It relates to a possible composition for immuno-enhancing.
최근 산업화와 환경의 변화 속에서 현대인들은 다양한 원인에 의한 면역력 저하로 인해 각종 질병에 노출되어 있으며, 이러한 질병 치료를 위해 막대한 비용을 소모하고 있다. 특히, 최근 오염된 공기 및 신생활 변화, 즉, 인스턴트 식품, 탄산음료 등의 과잉섭취 등으로 인해 면역체계에 이상이 발생하여 알러지성 질환들이 지속적으로 증가되고 있는 추세이다. 알러지성 질환은 여러 알러지 유발인자에 의해 인체 면역체계를 과도하게 항진시켜 대식세포와 같은 면역세포에서 TNF-α(tumor necrosis factor-α), IL-1(interleukin-1), IL-6(interleukin-6), 프로스타글란딘(prostagladin), 류코트리엔(luecotriene) 및 산화질소(nitric oxide, NO)와 같은 염증유발물질을 과도하게 유도하여 이는 염증반응으로 진행되어 알러지성 비염, 아토피성 피부염, 만성 천식 및 면역 과민반응 증상 등을 일으키는 것으로 알려져 있다. In the recent industrialization and changes in the environment, modern people are exposed to various diseases due to a decrease in immunity due to various causes, and are spending enormous costs for treating such diseases. In particular, allergic diseases are continuously increasing due to abnormalities in the immune system due to recent contaminated air and new life changes, that is, over-ingestion of instant foods, carbonated drinks, and the like. Allergic diseases are caused by excessive allergens in the human immune system, causing tumor necrosis factor-α (TNF-α), interleukin-1 (IL-1), and interleukin-6 (IL-6) in immune cells such as macrophages. -6) excessively induces proinflammatory substances such as prostaglandin, luecotriene and nitric oxide (NO), which progress to an inflammatory response that causes allergic rhinitis, atopic dermatitis, chronic asthma and immunity It is known to cause hypersensitivity symptoms.
이러한 면역질환을 예방 및 치료하기 위해, 여러 가지 약제가 개발되고 있으나, 대부분의 약제들이 화학약품들로 부작용이 있으며, 지속적인 치료효과를 내지 못하는 한계가 있었다.
In order to prevent and treat such immune diseases, various drugs have been developed, but most drugs have side effects with chemicals, and there is a limit that does not produce a continuous therapeutic effect.
한의학에서는 질병이 야기되기 이전에 예방하는 예방치료의 개념이 강하였으며, 종래의 보약이 이러한 개념이었다. 이러한 보약들의 대표적인 한의학적 처방약인 공진단은 녹용, 당귀, 산수유, 사향으로 구성된 처방으로 공진단의 활용을 살펴보면 노화를 방지하고 질병을 예방하는 경우, 수술이나 큰 병으로 원기가 쇠약해진 경우, 정신적 신체적 과로로 기력이 저하된 경우, 만성 피로가 심하여 휴식으로도 회복이 더딘 경우, 선천적으로 체질이 약한 경우, 혈액순환 저하로 몸이 무겁고 저린 경우, 신경이 예민하여 어지럼증과 불면증이 있는 경우, 과다한 스트레스와 음주로 간 기능이 약화된 경우 등에 유용하다고 알려져 있다. 동의보감에는 “대체로 남자가 장년시기에 진기(眞氣)가 몹시 약한 것은 타고날 때부터 약하고 허한 것이 아니므로 성질이 조(燥)한 약재를 쓰지 말아야 한다. 음혈을 보한다고 하는 처방들에 약품은 많으나 약효가 매우 약하여 효력을 보기 어렵다. 다만 타고난 원기를 든든히 하여 신수와 심화가 잘 오르내리게 되면 오장이 스스로 조화되고 온갖 병이 생기지 않을 것이다. 이런 때에는 이 처방을 쓴다.”라고 되어 있고 녹용(졸인 젖을 발라 구운 것), 당귀, 산수유 각각 160g, 사향(따로 간 것) 20g을 가루 내어 술을 두고 쑨 밀가루풀로 반죽한 다음 벽오동씨 만하게 알약을 만들어 한번에 70-100알씩 데운 술이나 소금 끓인 물로 복용하게 되어 있다. In oriental medicine, the concept of preventive treatment to prevent disease before it occurred was strong, and conventional medicine was such a concept. Resonant stage, which is a typical herbal medicine of these medicines, is composed of antler, donkey, cornus and musk. When the resonant stage is used, it prevents aging and prevents disease. Low energy, chronic fatigue, slow recovery from rest, congenital weakness, heavy and numbness due to poor blood circulation, nervousness, dizziness and insomnia, excessive stress and drinking It is known to be useful when the liver function is weakened. Consent of the agreement, “In general, the very weakness of men in the middle age, the weakness of the natural birth is not weak and vulnerable, and should not use the crude medicine. It is said that the prescription of bleeding is a lot of drugs, but the effect is very weak to be effective. However, if you have a strong natural energy and go up and down well, the five chapters will harmonize themselves, and all kinds of diseases will not occur. In this case, I write this prescription. ”And powdered 160g each of deer antler (grilled boiled milk), Angelica and cornus oil, 20g of musk (separate), put it with alcohol and knead it with flour paste. Make 70-100 tablets at a time with alcohol or salt boiled water.
그러나, 공진단의 주요성분 중 하나인 사향은 원료에 대한 공급이 원활하지 못하고 가격 또한 고가이며 진위에 대한 논란이 심하여 사용상의 문제가 있어 왔다. 또한, 최근에 사향의 대체품으로 사용하고 있는 목향은 의약품으로는 사용이 가능하지만 식품으로 개발할 수 없는 단점이 있다.
However, musk, which is one of the main components of the resonator stage, has a problem in use because the supply of raw materials is not smooth, the price is expensive, and the authenticity is serious. In addition, Mok-hyang, which has recently been used as a substitute for musk, can be used as a medicine, but has disadvantages that cannot be developed as a food.
이에, 본 발명자는 사향을 제외하면서도, 기존의 공진단과 유사한 약리 효과를 갖는 새로운 배합의 생약 조성물을 개발하기 위해, 연구를 거듭한 결과, 녹용, 산수유, 당귀, 진피, 구기자, 연근, 산약, 울금, 천마, 배초향, 계피, 복분자, 오미자 및 홍삼의 생약 추출물을 적정 성분비로 포함하는 조성물이 면역력 증진, 피로회복 및 성기능 항진 등의 효능을 나타내며, 환제로 제조시 식감이 우수하여 새로운 배합의 가미공진단으로 이용할 수 있음을 발견함으로써, 본 발명을 완성하였다.
Accordingly, the present inventors, while excluding musk, in order to develop a new combination herbal composition having a pharmacological effect similar to the existing resonator stage, as a result of the study, antler, cornus, donkey, dermis, wolfberry, lotus root, powder, turmeric Composition containing herbal extracts of medicinal herb, cheonma, pear scent, cinnamon, bokbunja, Schisandra chinensis and red ginseng shows proper efficacy of immunity improvement, fatigue recovery and sexual function improvement, and it is excellent in texture when manufactured as pill and it is a new combination of flavor test The present invention has been completed by discovering that it can be used as.
따라서, 본 발명의 목적은 녹용, 산수유, 당귀, 진피, 구기자, 연근, 산약, 울금, 천마, 배초향, 계피, 복분자, 오미자 및 홍삼의 추출물을 유효성분으로 포함하는 면역증강용 조성물을 제공하는 것이다.Accordingly, an object of the present invention is to provide an immuno-enhancing composition comprising extracts of antler, cornus, Angelica, dermis, goji berry, lotus root, medicinal herb, turmeric, cheonma, pear scent, cinnamon, bokbunja, Schisandra chinensis and red ginseng as active ingredients. .
본 발명의 다른 목적은 상기 조성물과 약제학적으로 허용가능한 담체를 포함하는, 면역질환 예방 또는 치료용 약학적 제제를 제공하는 것이다.Another object of the present invention is to provide a pharmaceutical preparation for preventing or treating immune diseases, comprising the composition and a pharmaceutically acceptable carrier.
본 발명의 또 다른 목적은 상기 조성물을 포함하는 면역질환 개선 및 피로회복 증진용 건강기능식품을 제공하는 것이다.
Another object of the present invention to provide a health functional food for improving immune disease and fatigue recovery comprising the composition.
하나의 양태로서, 본 발명은 녹용, 산수유, 당귀, 진피, 구기자, 연근, 산약, 울금, 천마, 배초향, 계피, 복분자, 오미자 및 홍삼의 생약 추출물을 유효성분으로 포함하는 면역증강용 조성물에 관한 것이다.
In one embodiment, the present invention relates to a composition for immuno-enhancing comprising an extract of herbal extracts of antler, cornus, donkey, dermis, goji berry, lotus root, medicinal herb, turmeric, cheonma, pear scent, cinnamon, bokbunja, Schisandra chinensis and red ginseng as active ingredients. will be.
본 발명의 조성물에 포함되는 각 생약 재료들은 재배한 것 또는 시판되는 것 등을 제한 없이 사용할 수 있으며, 생약 추출물을 제조하는 방법은 당업계의 통상적인 추출방법을 사용할 수 있다. 구체적으로, 건조, 동결 상태 또는 자연 그대로의 재료들을 적절히 세절하여 건조중량의 약 1 내지 15배, 바람직하게는 약 10 내지 15배 부피의 정제수(물), 탄소수 1 내지 4의 저급 알코올 또는 이들의 혼합용매를 사용하여 추출할 수 있다. 추출 방법은 열수 추출, 냉침 추출, 환류 냉각 추출 또는 초음파 추출 등을 이용할 수 있으며, 바람직하게는 열수 추출한다. 또한, 상기 추출물을 정제 및 농축하기 위해 여과하여 동결건조하여 사용할 수 있다.
Each herbal material included in the composition of the present invention may be grown or commercially available, without limitation, and the method of producing a herbal extract may use a conventional extraction method in the art. Specifically, dry, frozen or natural materials are appropriately chopped to provide about 1 to 15 times the dry weight of purified water (water), preferably lower alcohols having 1 to 4 carbon atoms or their alcohols. It can be extracted using a mixed solvent. The extraction method may use hot water extraction, cold needle extraction, reflux cooling extraction or ultrasonic extraction, and preferably hot water extraction. In addition, the extract may be filtered and lyophilized to be used for purification and concentration.
본 발명의 조성물에 포함되는 녹용은 사슴과(鹿科;Cervidae)에 속한 매화록(梅花鹿) Cervus nippon Temminck, 마록(馬鹿) C. elaphus Linne 또는 대록(大鹿) C. canadensis Erxleben의 숫사슴의 털이 밀생하고 아직 골질화되지 않았거나 약간 골질화 된 어린 뿔을 자른 다음 말린 것이다. 녹용에는 16 종류의 아미노산이 함유되어 있는데, 그 중에서 proline, lysine, serine의 함량이 가장 높은 것으로 알려져 있다. 녹용의 상대에는 amine류가 다량 함유되어 있는데 그 중에서 spermine, spermidine, putrescine이 풍부하다. 녹용의 중대와 하대에는 골화가 많이 진행된 상태이며 spermidine의 함량이 감소되어 있다. 이외에도 collagen, estrone, proteolipid 등이 함유되어 있다. Deer antler included in the composition of the present invention is the hair of the buck of Cervus nippon Temminck, Marok C. elaphus Linne or D. C. canadensis Erxleben belonging to the family Deeraceae (Cervidae) Cut and dry young horns that are dense and not yet ossified or slightly ossified. Deer Antler contains 16 kinds of amino acids, of which the highest content of proline, lysine and serine is known. Deer Antlers contain a large amount of amines, among them spermine, spermidine and putrescine. In the middle and bottom of the antler antler, ossification is much progressed and spermidine content is reduced. In addition, it contains collagen, estrone and proteolipid.
산수유는 층층나무과(山茶萸科:Cornaceae)에 속한 낙엽소교목인 산수유나무 Cornus officinalis Sieb. et. Zucc.의 성숙한 열매를 건조한 것으로, 果肉에는 cornin, 즉 verbenalin, saponin, tannin, ursolic acid 및 vitamin A가 함유되어 있고, 종자의 지방유에는 palmitin acid, olein acid, linol acid 등이 함유되어 있다. Cornus officinalis Sieb is a deciduous arborescent tree belonging to the Cornaceae family. et. Dried fruits of Zucc. Are dried, and contain cornin, verbenalin, saponin, tannin, ursolic acid and vitamin A, and seed oil contains palmitin acid, olein acid and linol acid.
당귀는 미나리과(形科:Umbelliferae)에 속한 다년생 초본인 당귀 참당귀 Angelica gigas Nakai의 뿌리를 건조시킨 것이다. 방향성분인 정유 및 데쿠신, 진정작용하는 베타시토스테롤, 자당, 니코틴산, 엽산 등의 성분으로 구성되어 있다. The Angelica gigas is the dried root of Angelica gigas Nakai, a perennial herb belonging to the Anaceae family. Consists of essential oils and decousins, sedating beta sitosterol, sucrose, nicotinic acid and folic acid.
진피는 운향과(芸香科:Rutaceae)에 속한 귤나무(橘) Citrus unshiu Markovich (=Citrus reticulata Blanco) 및 동속 근연식물의 성숙한 과실의 과피로 성분 중 정유성분으로 주성분은 d-limonine이며 이 외에도 hesperidin, myoinositol, vitamin C 등이 함유되어 있고 또한 flavonoide 배당체가 많이 함유되어 있다. The dermis is the fruit of the mature fruit of Citrus unshiu Markovich (= Citrus reticulata Blanco) of the Rheumaceae family and the related plant, and it is essential oil of d-limonine as well as hesperidin. , myoinositol, vitamin C, etc. It is also high in flavonoide glycosides.
구기자는 가지과(茄科:Solanaceae)에 속한 구기자나무 Lycium chinense Mill. 또는 기타 동속식물의 성숙한 과실로, Carotene 3.39㎎%, vitamin B1 0.23㎎%, vitamin B2 0.33㎎%, nicotin acid 1.7㎎%, vitamin C 3㎎%을 함유하고, β-sitosterol, linoleic acid등이 함유되어 있다. Goji berries are Lycium chinense Mill. Or other fruit of the same species, containing 3.39 mg% of carotene, 0.23 mg% of vitamin B1, 0.33 mg% of vitamin B2, 1.7 mg% of nicotin acid, 3 mg% of vitamin C, and β-sitosterol, linoleic acid, etc. It is.
산약은 마과(薯科:Dioscoreaceae)에 속한 마 Dioscorea batatas Decne.(=D. opposita Thunb.)와 참마 D. japonica Thunb.의 껍질을 제거한 뿌리줄기 Saponin, 점액, cholin, 전분(16%), glycoprotein과 유리amino산을 함유하며, 또한 abscisin Ⅱ, polyphenol 산화효소, vitamin C(5mg%), 3,4-dihydroxy-phenyle-thylamine(dopamine)을 함유하고 점액 중에는 mannan과 phytin산이 함유되어 있다. The medicinal products are the roots of Saponin, mucus, cholin, starch (16%) and glycoprotein from the skins of the Dioscorea batatas Decne (= D. opposita Thunb.) And Yam D. japonica Thunb. And free amino acids, abscisin II, polyphenol oxidase, vitamin C (5mg%), 3,4-dihydroxy-phenyle-thylamine (dopamine), and mucus contains mannan and phytin acid.
울금은 생강과(生薑科;Zingiberaceae)에 속한 鬱金 Curcuma aromatica Salisb. 또는 溫鬱金 C. wenyujin Y. H. Chen et C. Ling, 薑黃 C. longa L. 廣西莪朮 C. kwangsiensis S. Lee et C. F. Liang, 我朮 C. aeruginosa Roxb. 川鬱金 C. chuanyujin C. K. Hsieh et H. Zhang의 塊根을 건조한 것으로, 주성분으로는 精油 6.1%가 함유되어 있는데, 그 중에는 d-camphene 0.8%, d-camphor 2.5%, sesquiterpene(l-α-curcumene, l-β-curcumene) 65.5%, sesqui-terpene alcohol 22% 등이 들어 있고, 또 curcumin 0.3%, demethoxy-curcumine, bisdemethoxycurcumin, turmerone, arturmerone 등도 들어 있다. 그 작용은 강황과 유사하다. 그 밖에 澱粉 30~40%, 脂肪油 3%, 黃色色素와 carvone 및 phellandrene이 들어 있다. Curcuma is Curcuma aromatica Salisb belonging to the genus Zingiberaceae. Or C. wenyujin Y. H. Chen et C. Ling, C. longa L. C. kwangsiensis S. Lee et C. F. Liang, C. aeruginosa Roxb.鬱根鬱 of C. chuanyujin CK Hsieh et H. Zhang, which contains 6.1% of 精油, including d-camphene 0.8%, d-camphor 2.5%, and sesquiterpene (l-α-curcumene, l-β-curcumene) 65.5%, sesqui-terpene alcohol 22%, curcumin 0.3%, demethoxy-curcumine, bisdemethoxycurcumin, turmerone, arturmerone and the like. Its action is similar to turmeric. In addition, ~ 30-40%, 脂肪 油 3%, 黄色 色素 and carvone and phellandrene is contained.
천마는 난초과(蘭科:Orchidaceae)에 속한 천마 Gastrodia elata Bl.의 덩이뿌리를 건조한 것으로 Gastrodin, gastrodioside(p-hydroxybenzol), vanillyl alcohol, succinic acid, citric acid, palmitic acid, p-hydroxybenzaldehyde, 미량의 alkaloids 등을 함유하고 있다. 주성분으로 알려진 gastrodin함량은 산지에 따라 차이가 있으나 약 0.25~0.67% 정도이다. Chunma is a dried tuber of Gastrodia elata Bl. Belonging to the Orchidaceae family. Gastrodin, gastrodioside (p-hydroxybenzol), vanillyl alcohol, succinic acid, citric acid, palmitic acid, p-hydroxybenzaldehyde, trace alkaloids And the like. The gastrodin content, known as the main ingredient, varies depending on the region, but is about 0.25 to 0.67%.
곽향은 꿀풀과(脣形科:Labiatae)에 속한 배초향(藿香) Agastache rugosa (Fisch. et Meyer) O. Kuntze의 전초의 지상부로 6~7月 사이에 채취하여 햇볕에 말리거나 음건한다. 곽향에는 정유 0.28%를 함유되어 있으며, 주성분으로 methylchavicol이 80% 이상을 차지하고, anethole, anisaldehydel, α-limonene, ρ-metlioxycinnaldehyde, α-pinene, β-pinene, 3-ocatanone, 3-ocatanol, ρ-cymene, 1-octen-3-ol, linalool, 1-caryophyllene, β-elemen, β-humulene, β-farnesene, γ-cadinene, calamenene 등이 함유되어 있다. Gwakhyang is the ground part of the outpost of the ostrac of Agastache rugosa (Fisch. Et Meyer) O. Kuntze belonging to the Lamiaceae family, collected between June and July and dried in the sun or in the shade. It contains 0.28% of essential oils, methylchavicol is the main ingredient of 80% or more, anethole, anisaldehydel, α-limonene, ρ-metlioxycinnaldehyde, α-pinene, β-pinene, 3-ocatanone, 3-ocatanol, ρ- It contains cymene, 1-octen-3-ol, linalool, 1-caryophyllene, β-elemen, β-humulene, β-farnesene, γ-cadinene, and calamenene.
계피는 녹나무과(樟科:Lauraceae)에 속한 육계 Cinnamomum cassia Presl의 수피로 정유성분이 1~2% 함유되어 있는데, 그 주성분은 cinnamaldehyde가 75~90%이다. 성질은 뜨겁고 맛은 맥고 달다. Cinnamon is the bark of broiler Cinnamomum cassia Presl, a member of the camphor tree (Lauraceae), containing 1 ~ 2% of essential oils and 75 ~ 90% of cinnamaldehyde. The nature is hot, the taste is sweet and mack.
오미자는 오미자과(Schisandraceae)에 속한 오미자(북오미자) Schisandra chinensis Baill. 또는 화중오미자(남오미자) S. sphenanthera Rehd. et Wils.의 완숙한 과실을 건조한 것으로, 정유 약 3%가 함유되어 있으며, 정유 속에 다양의 sesquicarene, β2 -bisabclene, β-chamigrene, α-ylangene 등이 함유되어 있다. 건조된 과실은 citral 12%, 사과산 10% 및 소량의 주석산을 함유하고 그 밖에 과당, 수지 등이 함유되어 있다. Schisandra chinensis Baill, Schisandraceae belonging to Schisandraceae. Or Schisandra chinensis (South Schisandra chinensis) S. sphenanthera Rehd. et Wils.'s ripe fruits are dried, containing about 3% essential oils, and various sesquicarene, β2-bisabclene, β-chamigrene, and α-ylangene. The dried fruit contains 12% citral, 10% malic acid, and a small amount of tartaric acid, in addition to fructose, resin and the like.
복분자는 장미과(薔薇科:Rosaceae)에 속한 낙엽관목인 華東覆盆子 Rubus chingii Hu의 果實을 건조한 것으로 유기산, 당류, β-sitosterol및 소량의 vitamin C를 함유하고 있으며 항균작용과 Estrogen 유사작용이 있다. Bokbunja is a dried fruit of Rubus chingii Hu, a deciduous shrub belonging to the Rosaceae family, and contains organic acids, sugars, β-sitosterol and small amounts of vitamin C. It has antibacterial and Estrogen-like effects.
인삼은 두릅나무과(五加科:Araliaceae)에 속한 인삼 Panax ginseng C.A Mey의 뿌리를 가공한 것으로, 가을에 줄기와 잎이 마를 때 캐어 말린 것을 백삼이라 하고, 잔뿌리를 제거하고 쪄서 건조한 것을 홍삼이라 하며 설탕에 가공하여 건조한 것을 당삼이라 한다. 인삼에는 ginsenoside가 약 5.22% 함유되어 있다. 인삼 ginsenoside는 13종 이상의 saponin혼합물이며, 그 가운데에서 ginsenoside Rb1, Rc 및 Rg1의 함유량이 비교적 높다. saponin이 함유된 genin은 protopanaxadiol, protopanaxatriol, oleanol acid의 3종이 있다. 또한 정유가 약 0.05% 함유되어 있는데 여기에는 독특한 향기의 근원이 되는 β-elemen과 쉽게 수지로 변하는 panaxynol이 함유되어 있다. 또한 panax acid는 palmitin acid, stearin acid, olein acid, linol acid 등의 혼합물인데 뿌리에 함유되어 있는 지질의 가수분해에 의하여 생성된 것이다. 또 β-sitosterol, stigmasterol 및 campesterol과 daucosterol도 분리되었으며, cholin이 0.1~0.2% 함유되어 있는데 이것이 인삼의 강압성분이다. 또 많은 종류의 amino acid와 peptide류, vitamin AㆍBlㆍB2ㆍC 등과 포도당, 과당, 맥아당, 자당 등이 함유되어 있다.
Ginseng is processed from the root of Panax ginseng CA Mey, a member of the Araliaceae family. When the stems and leaves are dried in autumn, dried ginseng is called white ginseng, and the roots are removed and dried and red ginseng is called ginseng. Dried processed sugar is called ginseng. Ginseng contains about 5.22% of ginsenosides. Ginseng ginsenoside is a mixture of 13 or more saponins, among which ginsenosides Rb1, Rc and Rg1 are relatively high. There are three kinds of genin containing saponin: protopanaxadiol, protopanaxatriol and oleanol acid. It also contains about 0.05% essential oil, which contains β-elemen, a source of unique fragrance, and panaxynol, which is easily converted into resin. In addition, panax acid is a mixture of palmitin acid, stearin acid, olein acid, and linol acid. It is produced by hydrolysis of lipids contained in roots. In addition, β-sitosterol, stigmasterol, campesterol and daucosterol were also isolated and contain 0.1 ~ 0.2% cholin, which is the coercive component of ginseng. It also contains many types of amino acids, peptides, vitamins A, Bl, B2 and C, and glucose, fructose, maltose and sucrose.
본 발명의 면역증강용 조성물에 포함되는 각 구성성분의 함량은 녹용 5~25질량비, 산수유 5~25질량비, 당귀 5~25질량비, 진피 5~25질량비, 구기자 5~15질량비, 연근 5~15질량비, 산약 5~15질량비, 울금 5~15질량비, 천마 1~5질량비, 배초향 1~5질량비, 계피 1~5질량비, 복분자 1~5질량비, 오미자 1~5질량비 및 홍삼 1~5질량비로 포함할 수 있으며, 바람직하게는 녹용 10~15질량비, 산수유 10~15질량비, 당귀 10~15질량비, 진피 10~15질량비, 구기자 8~12질량비, 연근 8~12질량비, 산약 8~12질량비, 울금 8~12질량비, 천마 1~4질량비, 배초향 1~4질량비, 계피 1~4질량비, 복분자 1~4질량비, 오미자 1~4질량비 및 홍삼 1~4질량비로 포함하고, 더욱 바람직하게는 녹용 12질량비, 산수유 12질량비, 당귀 12질량비, 진피 12질량비, 구기자 10질량비, 연근 10질량비, 산약 10질량비, 울금 10질량비, 천마 2질량비, 배초향 2질량비, 계피 2질량비, 복분자 2질량비, 오미자 2질량비 및 홍삼 2질량비로 포함한다. The content of each component contained in the composition for immuno-enhancing according to the present invention is 5 to 25 mass ratio of antler, 5 to 25 mass ratio of cornus oil, 5 to 25 mass ratio of Angelica, 5 to 25 mass ratio of dermis, 5 to 15 mass ratio of goji berry, and 5 to 15 lotus root. In mass ratio, acid medicine 5-15 mass ratio, turmeric 5-15 mass ratio, 1-5 mass ratio of pear horse, 1-5 mass ratio of pearweed, 1-5 mass ratio of cinnamon, 1-5 mass ratio of bokbunja, 1-5 mass ratio of Schisandra chinensis and 1-5 mass ratio of red ginseng It may include, preferably 10-15 mass ratio of antler, 10-15 mass ratio of cornus oil, 10-15 mass ratio of donkey, 10-15 mass ratio of dermis, 8-12 mass ratio of wolfberry, 8-12 mass ratio of lotus root, 8-12 mass ratio of acid, It contains 8 to 12 mass ratio of turmeric, 1 to 4 mass ratio of cheonmama, 1 to 4 mass ratio of pearweed fragrance, 1 to 4 mass ratio of cinnamon, 1 to 4 mass ratio of bokbunja, 1 to 4 mass ratio of Schisandra chinensis and 1 to 4 mass ratio of red ginseng, more preferably 12 mass ratio, cornus oil 12 mass ratio, donkey 12 mass ratio, dermis 12 mass ratio, wolfberry 10 mass ratio, lotus root 10 mass ratio, acid medicine 10 mass ratio, turmeric 10 mass ratio, celestial horse 2 mass , Agastache rugosa includes a second weight ratio, cinnamon 2 mass ratio, the mass ratio bokbunja 2, Schisandra 2 weight ratio and the weight ratio 2 Red Ginseng.
본 발명의 면역증강용 조성물은 상기한 구성성분비를 가질 때, 세포독성을 나타내지 않으면서도 최적의 면역력 증강 효능을 나타낸다. 또한, 본 발명의 조성물이 환제 형태로 제공될 때, 상기한 구성성분비를 가지는 경우 식감이 우수하여 취식성이 높은 특징을 가진다.
When the composition for immuno-enhancing of the present invention has the above-described component ratio, it exhibits an optimal potency enhancing effect without showing cytotoxicity. In addition, when the composition of the present invention is provided in the form of a pill, when the composition ratio described above has an excellent texture and has a high brittleness.
또한, 본 발명의 면역증강용 조성물은 면역증진과 스트레스 해소, 성기능 항진 작용을 가짐을 특징으로 한다. In addition, the composition for immunopotentiation of the present invention is characterized by having an immune boosting and stress relief, hyperactivity.
본 발명의 면역증강용 조성물은 대표적인 한의학 처방약인 공진단의 주요구성성분으로 알려진 녹용, 산수유 및 당귀를 포함하면서, 다른 생약들, 진피, 구기자, 연근, 산약, 울금, 천마, 배초향, 계피, 복분자, 오미자 및 홍삼을 적정 비율로 포함함으로써, 면역증강 작용을 나타내므로, 사향이 제외된 가미공진단 제조에 이용될 수 있다. 따라서, 본 발명의 상기 조성물은 특히 환제 형태로 가공되는 것이 바람직하다. 이러한 환제 형태는 생약을 추출하여 농축한 후 각 약재를 분쇄기를 이용하여 극세말하여 추출물과 가루를 혼합하고, 약액과 혼합한 가루는 다시 분쇄기에 넣어 극세말을 하여 300 내지 500mesh의 체에 걸러내 미세한 입자로 만들어 꿀과 함께 환(丸) 또는 단(丹), 원(元) 등으로 제조할 수 있다. 이때, 복용의 편의성을 위해 6g 단위로 제작하여, 하루에 한 알 내지 두 알 섭취하게 할 수 있다. 또한, 환ㆍ단ㆍ원으로 만든 약재는 다시 식용 금박(또는 은박)을 사용하여 포장을 할 수 있다. 금 또는 은은 예로부터 환약을 만들 때 사용되어 마음을 안정시키고 방충 방부의 효과로 공진단이나 우황청심원 같은 처방에 보조재료로 이용하여 왔다. 또한, 다른 형태로는 환을 만드는 과정은 동일하게 하고 과거부터 염료로 사용해왔고 방충 방부의 효과가 있는 약재를 추출하여 표면에 코팅하여 사용할 수 있으며, 바람직하게는 자초 및 단삼 등의 한약재를 추출하여 천연 코팅할 수 있다.
Immunity-enhancing composition of the present invention, including the antler, cornus and Angelica known as the main constituents of the resonant stage, which is a typical Chinese medicine prescription, other herbal medicines, dermis, wolfberry, lotus root, powder, turmeric, cheonma, pear scent, cinnamon, bokbunja, By including Schisandra chinensis and red ginseng in an appropriate ratio, it exhibits an immune enhancing effect, and thus can be used for the preparation of falsity-free diagnostics. Therefore, the composition of the present invention is particularly preferably processed in the form of pills. The pill form is concentrated by extracting the herbal medicine and then finely pulverizing each medicine by using a grinder to mix the extract and powder, and put the powder mixed with the chemical liquid again into a grinder to filter the fine particles 300-500mesh sieve fine particles Can be made with honey or hwan (dan) or dan (元), yuan (yuan) and the like. At this time, it can be made in 6g units for the convenience of taking, to take one to two tablets per day. In addition, medicines made of round, sweet and round can be packaged again using edible gold leaf (or silver leaf). Gold or silver has long been used in making pills to stabilize the mind and have been used as an auxiliary material in prescriptions such as resonant stages and cow sulfur cheongsimwon with the effect of insect repellent protection. In addition, the process of making the ring in the other form is the same, and has been used as a dye since the past, and can be used by coating the surface by extracting the medicinal effect of insect repellent antiseptic, preferably by extracting herbal medicines such as licorice and salvia It can be a natural coating.
본 발명의 상기 조성물은 면역증강을 위한 약학적 제제 또는 건강기능식품으로 이용될 수 있다.The composition of the present invention can be used as a pharmaceutical preparation or health functional food for immune enhancement.
따라서, 또 다른 양태로서, 본 발명은 상기 면역증강용 조성물과 약제학적으로 허용가능한 담체를 포함하는 면역질환 예방 또는 치료용 약학적 제제에 관한 것이다.Therefore, as another aspect, the present invention relates to a pharmaceutical preparation for the prevention or treatment of immune diseases comprising the composition for immuno-enhancing and a pharmaceutically acceptable carrier.
본 발명에서 "면역질환"은 생체의 면역체계 이상으로 유발되는 다양한 염증성 질환, 알러지성 질환 및 암 등을 포함하며, 예를 들면, 감기, 천식, 폐렴, 알러지성 비염, 알러지성 결막염, 아토피성 피부염, 알러지, 류마티스 관절염, 알츠하이머병, 자가면역성 갑상선 질환, 염증성 장질환, 재생불량성 빈혈, 홍반성 루푸스 및 건선 등을 포함할 수 있으나, 이에 제한되는 것은 아니다.
In the present invention, "immune disease" includes various inflammatory diseases, allergic diseases and cancers caused by abnormal immune system of the living body, for example, cold, asthma, pneumonia, allergic rhinitis, allergic conjunctivitis, atopic dermatitis Dermatitis, allergy, rheumatoid arthritis, Alzheimer's disease, autoimmune thyroid disease, inflammatory bowel disease, aplastic anemia, lupus erythematosus and psoriasis, and the like, but are not limited thereto.
본 발명의 상기 조성물은 면역질환 예방 또는 치료를 위한 약학적 조성물로 제공될 수 있으며, 담체와 함께 제제화될 수 있다. 상기 본 발명의 약학적 조성물은 각각 통상의 방법에 따라 산제, 과립제, 정제, 캡슐제, 현탁액, 에멀젼, 시럽, 에어로졸 등의 경구형 제형, 외용제, 좌제 및 멸균 주사용액의 형태로 제형화하여 사용될 수 있으며, 추출물을 포함하는 조성물에 포함될 수 있는 담체, 부형제 및 희석제로는 락토즈, 덱스트로즈, 수크로스, 솔비톨, 만니톨, 자일리톨, 에리스리톨, 말티톨, 전분, 아카시아 고무, 알지네이트, 젤라틴, 칼슘 포스페이트, 칼슘 실리케이트, 셀룰로즈, 메틸 셀룰로즈, 미정질 셀룰로스, 폴리비닐 피롤리돈, 물, 메틸히드록시벤조에이트, 프로필히드록시벤조에이트, 탈크, 마그네슘 스테아레이트 및 광물유를 들 수 있다. 제제화할 경우에는 보통 사용하는 충진제, 증량제, 결합제, 습윤제, 붕해제, 계면활성제 등의 희석제 또는 부형제를 사용하여 조제된다. 경구투여를 위한 고형제제에는 정제, 환제, 산제, 과립제, 캡슐제 등이 포함되며, 이러한 고형제제는 상기 추출물에 적어도 하나 이상의 부형제 예를 들면, 전분, 칼슘카보네이트, 수크로스, 락토오스, 젤라틴 등을 섞어 조제된다. 또한, 단순한 부형제 이외에 마그네슘 스티레이트 탈크 같은 윤활제들도 사용된다. 경구를 위한 액상제제로는 현탁제, 내용액제, 유제, 시럽제 등이 해당되는데 흔히 사용되는 단순희석제인 물, 리퀴드 파라핀 이외에 여러 가지 부형제, 예를 들면 습윤제, 감미제, 방향제, 보존제 등이 포함될 수 있다. 비경구투여를 위한 제제에는 멸균된 수용액, 비수성용제, 현탁제, 유제, 동결건조제제, 좌제가 포함된다. 비수성용제, 현탁제로는 프로필렌글리콜, 폴리에틸렌 글리콜, 올리브 오일과 같은 식물성 기름, 에틸올레이트와 같은 주사 가능한 에스테르 등이 사용될 수 있다. 좌제의 기제로는 위텝솔, 마크로골, 카카오지, 라우린지, 글리세로제라틴 등이 사용될 수 있다.The composition of the present invention may be provided as a pharmaceutical composition for preventing or treating immune diseases, and may be formulated with a carrier. The pharmaceutical compositions of the present invention may be used in the form of powders, granules, tablets, capsules, suspensions, emulsions, syrups, aerosols, oral formulations, external preparations, suppositories, and sterile injectable solutions, respectively, according to conventional methods. Carriers, excipients and diluents that may be included in the composition comprising the extract may include lactose, dextrose, sucrose, sorbitol, mannitol, xylitol, erythritol, maltitol, starch, acacia rubber, alginate, gelatin, calcium phosphate , Calcium silicate, cellulose, methyl cellulose, microcrystalline cellulose, polyvinyl pyrrolidone, water, methylhydroxybenzoate, propylhydroxybenzoate, talc, magnesium stearate and mineral oil. When formulated, diluents or excipients such as fillers, extenders, binders, wetting agents, disintegrating agents, and surfactants are usually used. Solid preparations for oral administration include tablets, pills, powders, granules, capsules, and the like, and the solid preparations include at least one excipient such as starch, calcium carbonate, sucrose, lactose, gelatin, and the like. Mix is prepared. In addition to simple excipients, lubricants such as magnesium styrate talc are also used. Examples of the liquid preparation for oral use include suspensions, solutions, emulsions, and syrups. In addition to water and liquid paraffin, simple diluents commonly used, various excipients such as wetting agents, sweeteners, fragrances, preservatives and the like may be included . Formulations for parenteral administration include sterile aqueous solutions, non-aqueous solvents, suspensions, emulsions, lyophilized preparations, suppositories. Examples of the suspending agent include propylene glycol, polyethylene glycol, vegetable oil such as olive oil, injectable ester such as ethyl oleate, and the like. As the base of the suppository, utopsol, macrogol, cacao butter, laurin butter, glycerogelatin and the like can be used.
본 발명의 조성물이 약학적 조성물로 이용될 때, 생약 추출물은 전체 조성물 총 중량에 대하여 건조 중량 기준으로 0.0001 ~ 50중량%, 바람직하게는 0.1 ~ 20중량%의 함량으로 포함되어 제제화될 수 있다.
When the composition of the present invention is used as a pharmaceutical composition, the herbal extract may be formulated in an amount of 0.0001 to 50% by weight, preferably 0.1 to 20% by weight, based on dry weight, based on the total weight of the total composition.
본 발명의 조성물의 바람직한 투여량은 환자의 건강 상태 및 체중, 질병의 정도, 약물형태, 투여경로 및 기간에 따라 다르지만, 당업자에 의해 적절하게 선택될 수 있다. 그러나, 바람직한 효과를 위해서, 본 발명의 조성물은 총 생약 추출물의 건조 중량 기준으로 0.0001 내지 1000mg/kg, 바람직하게는 0.1 내지 100mg/kg의 양을 1일 1회 내지 수회로 나누어 투여할 수 있다.Preferred dosages of the compositions of the present invention vary depending on the patient's state of health and weight, the extent of the disease, the form of the drug, the route of administration and the duration, and may be appropriately selected by those skilled in the art. However, for the desired effect, the composition of the present invention may be administered in an amount of 0.0001 to 1000 mg / kg, preferably 0.1 to 100 mg / kg divided once to several times per day based on the dry weight of the total herbal extracts.
본 발명의 조성물의 투여 경로는 목적 조직에 도달할 수 있는 한 경구 또는 비경구의 다양한 경로를 통하여 투여될 수 있으며, 구체적으로, 구강, 직장, 국소, 정맥내, 복강내, 근육내, 동맥내, 경피, 비측내, 흡입, 안구 내 또는 피내경로를 통해 통상적인 방식으로 투여될 수 있다. 바람직하게는 경구 투여한다.
The route of administration of the composition of the present invention may be administered via various routes orally or parenterally as long as it can reach the target tissue, and specifically, oral, rectal, topical, intravenous, intraperitoneal, intramuscular, intraarterial, It may be administered in a conventional manner via transdermal, nasal, inhaled, intraocular or intradermal routes. Preferably oral administration.
본 발명의 조성물은 임의의 동물에 적용가능하며, 동물은 인간 및 영장류뿐만 아니라, 소, 돼지, 양, 말, 개 및 고양이 등의 가축을 포함한다. The composition of the present invention is applicable to any animal, the animal including humans and primates, as well as domestic animals such as cattle, pigs, sheep, horses, dogs and cats.
또한, 본 발명의 조성물은 염증 질환 및 알러지성 질환 등의 면역질환 예방 및 치료를 위하여 단독으로 사용하거나, 수술, 호르몬 치료, 약물 치료 및 생물학적 반응 조절제를 사용하는 방법들과 병용하여 사용할 수 있다.
In addition, the composition of the present invention can be used alone for the prevention and treatment of immune diseases such as inflammatory diseases and allergic diseases, or in combination with methods using surgery, hormone therapy, drug treatment and biological response modifiers.
또 다른 양태로서, 본 발명은 상기 면역증강용 조성물을 포함하는 면역질환 개선 및 피로회복 증진용 건강기능식품에 관한 것이다.As another aspect, the present invention relates to a health functional food for improving immune disease and fatigue recovery comprising the composition for immuno-enhancing.
본 발명의 상기 조성물은 염증 질환 및 알러지성 질환 등의 면역질환 예방 또는 개선이나 피로회복 증진을 위한 목적으로 건강기능식품에 첨가될 수 있다. 이때, 조성물에 포함되는 각 생약 재료들은 추출물 형태 외에도 재료 자체를 분말화하여 추가로 첨가하는 방식으로도 이용될 수 있다.The composition of the present invention may be added to a health functional food for the purpose of preventing or improving immune diseases, such as inflammatory diseases and allergic diseases, or to promote fatigue recovery. In this case, each herbal material included in the composition may be used in a manner of additionally adding the powder itself in addition to the extract form.
상기 건강기능식품은 최종 제품의 상품성과 소비자 기호도에 따라 다른 식품소재를 첨가하여 제조될 수 있다. 상기 조성물의 유효한 첨가량은 사용 목적(예방, 건강 또는 치료적 처치)에 따라 적합하게 결정될 수 있으며, 바람직하게는 총 원료에 대하여 생약 건조 중량을 기준으로 0.01 내지 90중량%, 더욱 바람직하게는 5 내지 30중량%로 첨가될 수 있다.The health functional food may be prepared by adding other food materials according to the commerciality and consumer preference of the final product. The effective amount of the composition may be suitably determined according to the purpose of use (prevention, health or therapeutic treatment), preferably 0.01 to 90% by weight, more preferably 5 to 5, based on the dry weight of the herbal medicine relative to the total raw material. It can be added at 30% by weight.
본 발명의 면역증강용 조성물은 식품학적으로 허용가능한 식품첨가제를 추가로 포함하여 제제화함으로써 제제 형태의 건강기능식품으로 제조할 수 있으며, 제제의 형태로는 정제, 캡슐제, 환제, 액제 등이 가능하다. Immunity-enhancing compositions of the present invention can be prepared as a health functional food in the form of a formulation by further comprising a food additive acceptable food formulation, the form of the formulation can be tablets, capsules, pills, liquids, etc. Do.
또한, 상기 조성물을 첨가할 수 있는 식품의 종류에는 특별한 제한은 없다. 예를 들면, 음료수, 차, 빵, 쵸코렛, 캔디류, 스넥류 및 비타민 복합제 등이 있으며, 통상적인 의미에서의 기능성 식품을 모두 포함한다.In addition, there is no particular limitation on the kind of food to which the composition can be added. Examples include beverages, tea, bread, chocolate, candy, snacks and vitamin complexes, and include all functional foods in the conventional sense.
또한, 본 발명의 건강기능식품은 다양한 향미제, 천연 탄수화물, 감미제, 비타민, 전해질, 착색제, 펙트산, 알긴산, 유기산, 보호성 콜로이드 증점제, pH 조절제, 안정화제, 방부제, 글리세린, 알콜, 탄산화제 등을 추가로 함유할 수 있다. 특히, 상기 천연 탄수화물로는 포도당, 과당과 같은 모노사카라이드, 말토스, 수크로오스와 같은 디사카라이드, 및 덱스트린, 사이클로덱스트린과 같은 폴리사카라이드, 자일리톨, 소르비톨, 에리트리톨 등의 당알콜을 사용할 수 있으며, 감미제로서는 타우마틴, 스테비아 추출물과 같은 천연 감미제나 사카린, 아스파르탐과 같은 합성 감미제 등을 사용할 수 있다. 이러한 첨가제의 비율은 크게 중요하진 않지만 본 발명의 조성물 100 ㎖ 당 0.01~10 g 정도의 범위에서 선택될 수 있다.
In addition, the health functional food of the present invention is a variety of flavors, natural carbohydrates, sweeteners, vitamins, electrolytes, colorants, pectic acid, alginic acid, organic acids, protective colloidal thickeners, pH regulators, stabilizers, preservatives, glycerin, alcohols, carbonating agents And the like may be further contained. In particular, the natural carbohydrate may be a sugar such as glucose, monosaccharides such as fructose, maltose, disaccharides such as sucrose, polysaccharides such as dextrin, cyclodextrin, xylitol, sorbitol, and erythritol. As a sweetener, natural sweeteners such as tautin and stevia extract, synthetic sweeteners such as saccharin, aspartame, and the like can be used. The ratio of such additives is not critical but may be selected in the range of 0.01 to 10 g per 100 ml of the composition of the present invention.
본 발명에 따른 녹용, 산수유, 당귀, 진피, 구기자, 연근, 산약, 울금, 천마, 배초향, 계피, 복분자, 오미자 및 홍삼의 추출물을 유효성분으로 포함하는 면역증강용 조성물은 면역증강 활성을 나타내면서도 인체 안정성이 뛰어나, 면역질환 예방 또는 치료를 위한 약학적 제제 또는 건강기능식품 제조에 유용하게 이용될 수 있다. Dexterity, cornus, Angelica, dermis, gojija, lotus root, powder, turmeric, cheonma, pear scented, cinnamon, bokbunja, Schisandra chinensis and red ginseng extracts according to the present invention as an active ingredient, while showing an immune enhancing activity Excellent in human stability, it can be usefully used in the manufacture of pharmaceutical preparations or nutraceuticals for the prevention or treatment of immune diseases.
또한, 본 발명의 면역증강용 조성물은 면역력 증진, 자양강장, 수험생 체력증진, 항노화, 피로회복증진 및 성기능 항진 등의 효과를 나타낼 뿐만 아니라, 환제 형태로 가공시 식감이 우수하여, 사향이 제외된 가미공진단 제조에 이용될 수 있다.
In addition, the composition for immuno-enhancing of the present invention not only shows the effects of enhancing immunity, nourishing tonic, physical strength of the examinee, anti-aging, fatigue recovery, and sexual enhancement, but also has excellent texture when processed into a pill form, musk is excluded. It can be used for the production of flavor test.
<실시예 1 내지 16><Examples 1 to 16>
녹용, 산수유, 당귀, 진피, 구기자, 연근, 산약, 울금, 천마, 배초향, 계피, 복분자, 오미자, 홍삼, 천궁, 작약, 숙지황, 복령, 건강, 우슬, 대추, 애엽 및 정향을 음건하고 세절하여, 각각 동일한 질량비로 하기 표 1에 따라 혼합하였다. 상기 혼합물에 각각의 혼합물 총 무게의 10배의 증류수를 가하고 10 시간 동안 끓여 열수 추출하였다. 상기 열수 추출물을 여과 후 감압 농축기를 이용하여 농축하였다. Detox and finely cut antler, cornus, donkey, dermis, wolfberry, lotus root, medicinal powder, turmeric, cheonma, pear herb, cinnamon, bokbunja, omija, red ginseng, cheongung, peony, sukjiji, bokyeong, health, dew, jujube, leaf and clove , Each was mixed according to the following Table 1 in the same mass ratio. Distilled water 10 times the total weight of each mixture was added to the mixture and boiled for 10 hours to extract hot water. The hot water extract was filtered and concentrated using a vacuum concentrator.
<실험예 1>Experimental Example 1
건강한 성인의 혈액을 채취하여 실온에서 약 15분간 방치하여 응고시킨 후, 응고된 혈액을 절단하고 약 5분간 상온에서 방치시킨다. 이 혈액을 다시 4℃에서 약 20분간 방치한 다음 원심분리(3,000 rpm, 20분, 4℃)하여 혈청을 분리한 뒤 미량 원심분리용 튜브에 1 mL씩 분주하여 -70℃에서 냉동 보관하여, 시험에 사용하였다. Blood from healthy adults is collected and left to coagulate for about 15 minutes at room temperature, and then the coagulated blood is cut and left to stand at room temperature for about 5 minutes. The blood was left to stand again at 4 ° C. for about 20 minutes, and then centrifuged (3,000 rpm, 20 minutes, 4 ° C.) to separate serum, and then, 1 mL was dispensed into a small centrifuge tube and frozen at -70 ° C., Used for the test.
상기 혈청에 GVB++(gelatin veronal buffer, pH 7.4, 0.1% gelatin, 0.15 mM Ca++, 0.5 mM Mg++ 함유) 및 실시예 1 내지 16의 추출물을 각각 50 μL씩 혼합하여 37℃에서 30분간 1차 반응 시켰다. 그 후, GVB++ 350 μL를 가하고, 이를 10~160배 까지 연속 희석시켜, 750 μL의 GVB++와 양의 감작적혈구 (Ig M-sensitizated sheep erythrocyte, EA cell, 1× 108 cells/mL) 250 μL를 가하여 37℃에서 50분간 2차 반응시켰다. 그 후 PBS(phosphate buffered saline, pH 7.4) 2.5 mL를 가하여 반응을 정지시켰다. 상기 반응액은 2,000 rpm에서 10분간 원심분리하였으며, 얻어진 상등액을 412 nm에서 흡광도를 측정하여 잔존 용혈활성을 측정하였다.
GVB ++ (containing gelatin veronal buffer, pH 7.4, 0.1% gelatin, 0.15 mM Ca ++, 0.5 mM Mg ++) and 50 μL of the extracts of Examples 1 to 16 were mixed in the serum, followed by primary reaction at 37 ° C. for 30 minutes. Then, 350 μL of GVB ++ was added and serially diluted to 10-160 fold to 750 μL of GVB ++ and 250 μL of positive erythrocytes (Ig M-sensitizated sheep erythrocyte, EA cell, 1 × 10 8 cells / mL). The reaction was carried out for 2 minutes at 37 ° C. for 50 minutes. Thereafter, 2.5 mL of PBS (phosphate buffered saline, pH 7.4) was added to stop the reaction. The reaction solution was centrifuged at 2,000 rpm for 10 minutes, and the obtained supernatant was measured for absorbance at 412 nm to measure residual hemolytic activity.
항보체 활성은 정상인의 혈청과 GVB++, 증류수만을 반응시킨 음성대조군의 총보체용혈(50% total complement hemolysis, TCH50, %)에 대한 저지율(inhibition of 50% total complement hemolysis, ITCH50, %)로써 나타내었다. 양성대조군으로는 polysaccharide K(PSK)를 사용하였다.
Anti-complement activity was expressed as inhibition of 50% total complement hemolysis (TCH 50,%) of the negative control group which reacted only with normal serum, GVB ++ and distilled water (ITCH 50,%). . Polysaccharide K (PSK) was used as a positive control.
<식 1><Equation 1>
ITCH50 (%)=(대조군의TCH50-실시예의 TCH50 / 실시예의TCH50) X 100
ITCH 50 (%) = (Control TCH 50 -Example TCH 50 / Example TCH 50 ) X 100
그 결과, 실시예 1, 4, 7, 12, 13, 14의 ITCH50이 높은 것으로 확인되었다(표 2). 그러므로 항보체 활성이 높은 녹용, 산수유, 당귀, 진피, 구기자, 연근, 산약, 울금, 천마, 배초향, 계피, 복분자, 오미자 및 홍삼을 이용하여 이후의 실험을 진행하였다.
As a result, it was confirmed that the ITCH 50 of Examples 1, 4, 7, 12, 13, 14 was high (Table 2). Therefore, the experiments were carried out using anti-complement activity of deer antler, cornus, Angelica, Dermis, Gojija, lotus root, powder, turmeric, Cheonma, Pearweed, Cinnamon, Bokbunja, Schisandra chinensis and Red Ginseng.
<실시예 15~31><Examples 15-31>
녹용, 산수유, 당귀, 진피, 구기자, 연근, 산약, 울금, 천마, 배초향, 계피, 복분자, 오미자 및 홍삼을 하기 표 3의 질량비로 혼합하였다. 상기 혼합물에 각각의 혼합물 총 무게의 10배의 증류수를 가하고 10 시간 동안 끓여 열수 추출하였다. 상기 열수 추출물을 여과 후 감압 농축기를 이용하여 농축하였다.
Deer Antler, Cornus, Angelica, Dermis, Wolfberry, Lotus Root, Potion, Turmeric, Cheonma, Pearweed, Cinnamon, Bokbunja, Schisandra chinensis and Red Ginseng were mixed in the mass ratio of Table 3 below. Distilled water 10 times the total weight of each mixture was added to the mixture and boiled for 10 hours to extract hot water. The hot water extract was filtered and concentrated using a vacuum concentrator.
<실험예 2>Experimental Example 2
비장(spleen)은 혈액으로부터 항원을 수집하여, B 및 T 림프구의 성숙과 항원에 의해 자극받은 후 림프구의 분화가 이루어지는 주요 림프기관으로 비장 내 림프구의 증식은 면역시스템에 있어 매우 중요한 의미를 갖는다.
The spleen is a major lymphoid organ that collects antigens from the blood, maturates B and T lymphocytes and is stimulated by antigens, and then differentiates lymphocytes. Proliferation of lymphocytes in the spleen is very important for the immune system.
6~8주령 암컷 Balb/c 마우스를 1 주일 동안 23 ℃, 40-60 % 습도, 12시간 명암주기 조건환경에서 적응시켰다. 그 후, 실시예 17~27의 추출물을 70 ml/kg 의 용량으로 첨가하여 일반 사료(퓨리나)와 함께 1달 간 투여하고, 혈액을 채취하였다. 형광색소(FITC, PE)를 이용하여 염색 후 유세포분석기(flow cytometry)를 이용하여 상기 혈액 내 총 T 림프구 및 총 B 림프구의 수를 측정하였다(표 4).
Six to eight week old female Balb / c mice were acclimated for one week at 23 ° C., 40-60% humidity, and 12 hour light cycle conditions. Thereafter, the extracts of Examples 17 to 27 were added at a dose of 70 ml / kg, administered with a general feed (purina) for 1 month, and blood was collected. After staining with fluorochromes (FITC, PE), the number of total T lymphocytes and total B lymphocytes in the blood was measured using flow cytometry (Table 4).
*B 림프구 및 T 림프구는 세포수 X 10 5으로 나타냄.
* B lymphocytes and T lymphocytes are indicated by cell number X 10 5 .
그 결과, 실시예 15, 21, 22, 25, 26 및 27의 추출물을 투약 시 면역 증강 효능이 높아지는 것을 확인하였다. 이를 종합하여 보면, 녹용, 산수유, 당귀, 진피, 구기자, 연근, 산약, 울금, 천마, 배초향, 계피, 복분자, 오미자 및 홍삼을 각각 5~25: 5~25: 5~25: 5~25: 10~15: 10~15: 10~15: 10~15: 1~5: 1~5: 1~5: 1~5: 1~5: 1~5 의 질량비로 혼합하여 열수추출하는 것이 효과가 좋으며, 총 약재 중 녹용, 산수유, 당귀 및 진피의 비율이 낮을수록 면역 증강 효과가 낮은 것으로 판단되었다.As a result, it was confirmed that when the extracts of Examples 15, 21, 22, 25, 26, and 27 were administered, the immune enhancing effect was increased. Taken together, Deer Antler, Cornus, Angelica, Dermis, Gojija, Lotus Root, Powder, Turmeric, Cheonma, Pearweed, Cinnamon, Bokbunja, Schisandra chinensis and Red Ginseng, 5-25: 5-25: 5-25: 5-25: 5-25: 10 ~ 15: 10 ~ 15: 10 ~ 15: 10 ~ 15: 1 ~ 5: 1 ~ 5: 1 ~ 5: 1 ~ 5: 1 ~ 5: 1 ~ 5 It was judged that the lower the ratio of antler, cornus, angelica and dermis in the total medicinal herbs, the lower the immune enhancing effect.
Claims (7)
Health functional food for improving immune diseases and fatigue recovery comprising the composition of claim 1.
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