KR20090043973A

KR20090043973A - Dermal filler composition

Info

Publication number: KR20090043973A
Application number: KR1020070109811A
Authority: KR
Inventors: 조강선
Original assignee: 조강선
Priority date: 2007-10-30
Filing date: 2007-10-30
Publication date: 2009-05-07

Abstract

The present invention relates to a composition of a new skin filler which can be injected into the body through injections to give an arbitrary form quickly, and more specifically, does not require pretreatment such as an allergic reaction test before the procedure, and is inexpensive. As it is not easily disintegrated and absorbed by the body, it can maintain the volumetric effect by the procedure for a longer period of time. The present invention relates to a new skin filler composition having a softer touch, which can be used not only on the skin of the penis but also on the skin of a wide range of the human body including the face. To this end, the present invention is characterized by consisting of polymethyl methacrylate (PMMA), hyaluronic acid (hyaluronic acid) or cross-linked hyaluronic acid (cross-linked hyaluronic acid), hydroxypropyl methylcellulose (HPMC) and physiological saline or distilled water. It provides a new dermal filler composition.

Dermal fillers, polymethylmethacrylate (PMMA), hyaluronic acid, cross-linked hyaluronic acid, hydroxypropyl methylcellulose (HPMC)

Description

Dermal Filler Composition {DERMAL FILLER COMPOSITION}

The present invention relates to dermal filler compositions, and more particularly, to polymethylmethacrylate (PMMA), hyaluronic acid or cross-linked hyaluronic acid, hydroxy A novel dermal filler composition comprising propyl methylcellulose (HPMC, hydroxypropyl methylcellulose) and physiological saline or distilled water.

Soft tissues of the human body are maintained by extracellular matrix including proteins such as collagen and elastin and glycosaminoglycans, and soft tissues caused by congenital factors or external shocks or pathological factors. When a defect occurs, the shape has been restored and corrected by inserting biological tissue or synthetic polymer chemical into the region to expand the soft tissue. On the other hand, a substance similar to skin tissue is used to improve wrinkles or contours by inserting it into a specific area and expanding soft tissue, and it is generally called a dermal filler or filler. Therefore, it can be classified into two types as follows. First of all, it is a skin filler that directly increases the volume to give an enlargement effect. The main component of the skin filler is composed of a substance such as collagen or hyaluronic acid. On the other hand, there is also a skin filler component, such as cross-linked dextran to increase the volume by directing a foreign body reaction for a certain period of time, in addition to a part of the volume-increasing action to induce self-collagen formation for a long time or permanently. Meanwhile, polymethyl methacrylate (PMMA) is known as a material having both types of functional mechanisms.

Preferred dermal fillers are required to have several conditions, such as not originating from animals, effecting quickly and lasting as long as possible, natural and comfortable bulking at low cost.

Currently, many skin fillers are based on collagen or hyaluronic acid. First of all, collagen-based skin fillers include EVOLENCE 30 (brand name of ColBar LifeScience skin filler), poyrine collagen, Zyderm and Zyplast (above, brand name of Inamed skin filler), human collagen. CosmoDerm and CosmoPlast (trade name of skin fillers of Inamed Co., Ltd.) are known as the main ingredient. Main ingredients of hyaluronic acid include Rofilan (trade name of Rofil / Philoderm dermal filler), Perlane, Restylane (trade name of dermal filler of Medicis / Q-Med AB company), Teosyal (derived skin filler of Teoxane SA company) Trade name), Surgiderm (trade name of Corneal Laboratoire dermatological fillers), and the like. However, dermal fillers based solely on collagen or hyaluronic acid are expensive and their duration of effect is too short, limiting their practical use in clinical practice.

Other longer-lasting products include MATRIDEX (trade name for skin fillers from BioPolymer GmbH & Co.KG), which is based on DEAE sephadex cross-linked with hyaluronic acid. Skin fillers consisting of dextran particles crosslinked with hyaluronic acid as the main ingredient have a volume-increasing effect upon injection, and hyaluronic acid is decomposed and absorbed over 6 to 12 months and the space is crosslinked. Dextran stimulation causes the newly formed autologous collagen to fill. Hyaluronic acid is an interstitial component between the epidermis and the dermis, which connects cells to each other and acts as a lubricant between cells. Hyaluronic acid, which is used for injectable dermal fillers, is an artificially synthesized product. use. On the other hand, hyaluronic acid (hyaluronic acid) is also decomposed within one year and eventually decomposed to the cross-linked dextran within one to two years, so the period of maintaining the bulking effect by the dermal filler is short, hyaluronic acid (hyaluronic acid) is added, there is a problem that the dermal filler is quite expensive.

Products that have a longer lasting effect than crosslinked dextran-derived skin fillers include polymethylmethacrylate (PMMA) and collagen-based Artefill (trademark of Artes Medical dermal fillers). First, in the case of the dermal filler which maintains a bulking effect by purifying bovine collagen and making it into a liquid state, mixing it with polymethyl methacrylate (PMMA) and injecting it under the dermis. The methacrylate (PMMA) has an effect of expanding immediately upon injection, and maintains the bulking effect by filling the empty space created by decomposition and absorption of collagen with its collagen newly formed by stimulation of polymethyl methacrylate (PMMA). have. However, since the collagen used is derived from animals as a bovine extract, pretreatment such as an allergic skin test is necessary before use, which is a major obstacle in clinical application. In addition, since the collagen component is quite expensive, the patient's economic burden is large, and it is difficult to ensure the volume maintenance due to the new collagen formation because it is decomposed and absorbed too quickly in the human body at the time of infusion (absorbed in three to six weeks). There are disadvantages.

Recently, skin filler compositions based on polymethyl methacrylate (PMMA) and cross-linked dextran have been introduced to improve the problems of conventional skin fillers as described above. This composition does not require pre-treatment such as allergic reaction test before the procedure, and it is inexpensive and does not dissolve and absorb easily in the body, so the effect lasts for a long time. There is an advantage that can be usefully used even when the injection of. However, the composition is suitable for enlarged injection penis because it feels a little hard when injected under the skin, but has a disadvantage of being unsuitable for use in a wide range of other parts of the human body, including the face that requires a softer touch.

Therefore, it does not require any pre-treatment such as allergic reaction test before the procedure, it is inexpensive, and it is not easily decomposed and absorbed by the body, so the effect lasts for a long time and has a softer touch. There is a need for newer skin filler compositions that can also be used in the skin of the site.

The present invention is to solve the problems of the conventionally used skin fillers, such as allergic reaction test before the procedure because it does not contain collagen while maintaining a rapid expansion of the application site by injecting a skin filler under the dermis through injection It does not require pretreatment and is cheaper than conventional skin fillers. Unlike conventional skin fillers containing only collagen or hyaluronic acid as main ingredients, it is not easily broken down and absorbed by the body. It is possible to provide a skin filler composition suitable for use in surgery such as injection penis enlargement that requires the injection of a large amount of skin filler of 20 cc or more, since the volume enlargement effect by the long term can be stably maintained.

Another object of the present invention is to soften the texture when injected under the skin, unlike the conventional dermal filler mainly composed of dextran cross-linked with polymethyl methacrylate (PMMA), the skin of the penis as well as other parts of the human body, including the face It is an object of the present invention to provide a new skin filler composition that can be used for a wide range of skin.

In order to achieve the above object, a novel dermal filler composition according to the present invention is polymethyl methacrylate (PMMA), hyaluronic acid (hyaluronic acid) or cross-linked hyaluronic acid, hydroxypropyl methylcellulose ( HPMC) and physiological saline or distilled water.

In addition, according to another aspect of the present invention, the dermal filler composition is polymethylmethacrylate (PMMA) and hyaluronic acid (hyaluronic acid) (hyaluronic acid) or cross-linked hyaluronic acid (cross-linked hyaluronic acid) 1 to 0.10 to 5 20 to 80% by volume of the mixture, and 20 to 80% by volume of physiological saline or distilled water, and polymethyl methacrylate (PMMA), hyaluronic acid or cross-linked hyaluronic acid. acid) and 5-40 mg of hydroxypropyl methyl cellulose (HPMC) per 1 g of the mixture consisting of saline or distilled water.

When the procedure is performed using the skin filler composition according to the present invention, the skin filler is injected under the dermis through injection, so that the pretreatment such as an allergic reaction test is performed before the procedure because it does not contain collagen while maintaining rapid expansion of the application area. It is not required, and it is cheaper than conventional skin fillers. Unlike conventional skin fillers containing only collagen or hyaluronic acid as main ingredients, it is not easily decomposed and absorbed by the body. It can be stable for a longer period of time and is suitable for use in surgery such as enlarged injection penis which requires injection of a large amount of skin filler over 20cc. In addition, unlike conventional skin fillers have a soft touch when injected under the skin has an excellent effect that can be used not only on the skin of the penis but also on the skin of a wide range of other parts of the human body, including the face.

The present invention is characterized in that the polymethyl methacrylate (PMMA), hyaluronic acid (hyaluronic acid) or cross-linked hyaluronic acid (cross-linked hyaluronic acid), hydroxypropyl methylcellulose (HPMC) and physiological saline or distilled water The present invention relates to a novel dermal filler composition comprising polymethyl methacrylate (PMMA) and hyaluronic acid or cross-linked hyaluronic acid in a volume ratio of 0.10 to 5. 20 to 80% by volume of the blended mixture and 20 to 80% by volume of physiological saline or distilled water, polymethyl methacrylate (PMMA), hyaluronic acid or cross-linked hyaluronic acid, and Dermal fille, characterized in that 5-40 mg of hydroxypropyl methylcellulose (HPMC) is added per 1 ml of a mixture of physiological saline or distilled water r) relates to a composition.

Polymethylmethacrylate (PMMA), a major component of the dermal filler composition, is a microprototype with a diameter of 30 to 120 μm, which induces peripheral fibrosis in tissues without being predated by macrophage and thus surrounding It is large enough not to move easily. When polymethyl methacrylate (PMMA) is injected into the skin, it directly increases its volume and expands, while remaining unabsorbed by the human body to induce collagen synthesis of fibroblasts in the body for a long time or permanently. It wraps around methacrylate (PMMA) and each microprototype is encapsulated to fill wrinkles or recessed areas.

Hyaluronic acid or cross-linked hyaluronic acid, which is another component of the present invention skin filler composition, itself is a skin constituent, when directly injected into the tissue to increase the volume of the skin Although it shows an expanding effect, it has a characteristic of being decomposed and absorbed within a certain period of time. Usually hyaluronic acid can be used between 800,000 and 5 million M.W., and is usually absorbed within 3 weeks. Cross-linked hyaluronic acid is decomposed and absorbed within one year.

Therefore, the present invention, which is composed mainly of polymethyl methacrylate (PMMA) and hyaluronic acid or cross-linked hyaluronic acid, shows an immediate effect upon injection under the skin and hyaluronic acid (hyaluronic). acid and / or cross-linked hyaluronic acid to fill the voids created by the collagen newly formed by the stimulation of polymethyl methacrylate (PMMA) to maintain the volumetric effect for a long time stable Will be done.

In the present invention, polymethyl methacrylate (PMMA) and hyaluronic acid (hyaluronic acid) or cross-linked hyaluronic acid (cross-linked hyaluronic acid) is preferably mixed in a volume ratio of 1 to 0.10 to 5, relatively polymethyl meth Higher percentages of methacrylate (PMMA) can make it difficult to inject dermal fillers, and relatively high proportions of hyaluronic acid or cross-linked hyaluronic acid will retain the initial expansion effect. Failure to maintain may occur.

Dermal filler composition according to the present invention has a total volume of 100 to 20 to 80 of the volume of the mixture of polymethyl methacrylate (PMMA) and hyaluronic acid (hyaluronic acid) or cross-linked hyaluronic acid (cross-linked hyaluronic acid) It is preferably in the% range, and the remainder of the skin filler composition is filled with saline or distilled water, it is also possible to use sterilized water instead of saline. On the other hand, when using physiological saline or sterilized water, acid or base such as lactic acid (phosphate) or phosphate (phosphate) may be additionally added to adjust the pH.

Hydroxypropyl methylcellulose (HPMC) is a skin filler that allows a mixture of polymethylmethacrylate (PMMA) and hyaluronic acid or cross-linked hyaluronic acid to remain gel. It is a function of facilitating the injection of hydroxy per IX of mixed solution consisting of polymethyl methacrylate (PMMA), hyaluronic acid or cross-linked hyaluronic acid and physiological saline or distilled water. Propyl methylcellulose (HPMC) in the range of 5 to 40 mg may be appropriately added to suit the procedure.

On the other hand, the material that functions like hydroxypropyl methyl cellulose (HPMC), such as sodium carboxymethyl cellulose (sodiumcarboxymethylcellulos), chitosan (chitosan), polyethylene glycol (PEG), polylactic glycolamide (PLGA) , Polyvinyl alcohol (PVA), and the like, and may be added to the skin filler composition according to the present invention in place of hydroxypropyl methylcellulose (HPMC).

Claims

Dermal filler composition comprising polymethylmethacrylate (PMMA), hyaluronic acid or cross-linked hyaluronic acid, hydroxypropyl methylcellulose (HPMC) and physiological saline or distilled water .

20 to 80% by volume of polymethyl methacrylate (PMMA) and hyaluronic acid or cross-linked hyaluronic acid in a volume ratio of 0.10 to 5 with physiological saline or distilled water 20 Hydroxypropyl methyl per mixture of polymethyl methacrylate (PMMA), hyaluronic acid or cross-linked hyaluronic acid and physiological saline or distilled water. Dermal filler composition, characterized in that 5-40 mg of cellulose (HPMC) is added.