KR20070103038A - 전달 제어 시스템을 구비한 경피 시스템 - Google Patents
전달 제어 시스템을 구비한 경피 시스템 Download PDFInfo
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- KR20070103038A KR20070103038A KR1020077018841A KR20077018841A KR20070103038A KR 20070103038 A KR20070103038 A KR 20070103038A KR 1020077018841 A KR1020077018841 A KR 1020077018841A KR 20077018841 A KR20077018841 A KR 20077018841A KR 20070103038 A KR20070103038 A KR 20070103038A
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- South Korea
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- delivery system
- active agent
- transdermal delivery
- adhesive
- adhesive layer
- Prior art date
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- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
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- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
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Abstract
Description
Claims (42)
- 후면층(backing layer), 상기 후면층내에 배치된 중합체 막, 경피 전달 시스템을 환자의 피부 또는 점막에 부착시키기 위한 접착제층 및 상기 경피 전달 시스템이 환자의 피부 또는 점막에 부착되기 전 접착제층을 덮기 위한 박리층을 포함하는 활성제를 환자의 피부 또는 점막에 전달하기 위한 경피 전달 시스템으로서, 중합체 막에는 이를 통한 환자의 피부 또는 점막으로의 활성제의 전달율을 변경시키기 위한 소정량의 유체 매질이 함침되어 있고, 유체 매질의 소정량은 중합체 막 건조시 중합체 막에 의해 보유된 유체 매질의 양보다 실질적으로 많은 것인 경피 전달 시스템.
- 제1항에 있어서, 유체 매질이 활성제용 용매, 활성제용 증강제, 활성제용 부형제 및 활성제로 구성된 군중에서 선택된 액체를 포함하는 경피 전달 시스템.
- 제1항에 있어서, 접착제층이 제1 접착제층을 포함하고, 후면층과 중합체 막 사이에 배치된 제2 접착제층을 포함하는 경피 전달 시스템.
- 제3항에 있어서, 제1 및 제2 접착제층 각각은 아크릴, 실리콘, 폴리이소알칼리류, 고무, 비닐 아세테이트, 폴리이소부틸렌 고무, 폴리부타디엔, 스티렌-부타디엔, 셀룰로스 유도체, 다당류, 폴리우레탄 탄성중합체 및 폴리에스테르 탄성중합체 로 구성된 군중에서 선택된 접착제를 포함한 접착 매트릭스를 포함하는 경피 전달 시스템.
- 제4항에 있어서, 접착제가 아크릴, 실리콘, 고무, 스티렌-부타디엔 고무 및 폴리이소부틸렌으로 구성된 군중에서 선택되는 경피 전달 시스템.
- 제5항에 있어서, 접착제가 아크릴 접착제를 포함하는 경피 전달 시스템.
- 제2항에 있어서, 유체 매질이 활성제용 용매를 포함하는 경피 전달 시스템.
- 제7항에 있어서, 용매가 C2-C8 알콜을 포함하는 경피 전달 시스템.
- 제4항에 있어서, 제1 접착제층이 활성제를 포함하는 경피 전달 시스템.
- 제4항에 있어서, 제2 접착제층이 활성제를 포함하는 경피 전달 시스템.
- 제4항에 있어서, 제1 접착제층 및 제2 접착제층이 모두 활성제를 포함하는 경피 전달 시스템.
- 제1항에 있어서, 중합체 막이 친수성 및 소수성 중합체 및 공중합체로 구성된 군중에서 선택된 중합체를 포함하는 경피 전달 시스템.
- 제12항에 있어서, 중합체 막이 폴리올레핀, 에틸렌-비닐 아세테이트, 폴리비닐 아세테이트, 폴리에테르 블록 아미드, 폴리우레탄, 폴리아미드, 셀룰로스, 셀룰로스 유도체, 폴리비닐 클로라이드, 폴리비닐 알콜, 폴리스티렌, 폴리메틸 메타크릴레이트, 폴리실란 및 폴리실록산으로 구성된 군중에서 선택되는 경피 전달 시스템.
- 제1항에 있어서, 유체 매질의 소정량이 약 0.5 내지 10 mg/㎠를 포함하는 경피 전달 시스템.
- 제14항에 있어서, 유체 매질의 소정량이 약 1 내지 7 mg/㎠를 포함하는 경피 전달 시스템.
- 제15항에 있어서, 유체 매질의 소정량이 약 3.0 mg/㎠를 포함하는 경피 전달 시스템.
- 제3항에 있어서, 제1 및 제2 접착제층이 활성제용 용매에 의한 가소화에 적어도 부분적으로 내성인 접착제를 포함하는 경피 전달 시스템.
- 후면층, 상기 후면층내에 배치된 중합체 막, 경피 전달 시스템을 환자의 피부 또는 점막에 부착시키기 위한 접착제층, 상기 경피 전달 시스템이 환자의 피부 또는 점막에 부착되기 전 상기 접착제층을 덮기 위한 박리층 및 유체 매질의 약 25% 내지 100%가 중합체 막에 배치되도록 하는 방식으로 상기 접착제층과 상기 중합체 막 사이에 분포된 유체 매질을 포함하는, 활성제를 환자의 피부 또는 점막에 전달하기 위한 경피 전달 시스템.
- 제18항에 있어서, 유체 매질의 약 50% 내지 100%가 중합체 막에 배치되어 있는 경피 전달 시스템.
- 제18항에 있어서, 접착제층에 배치된 것보다 더 많은 양의 유체 매질이 중합체 막에 배치되어 있는 경피 전달 시스템.
- 제18항에 있어서, 유체 매질이 활성제용 용매, 활성제용 증강제, 활성제용 부형제 및 활성제로 구성된 군중에서 선택된 액체를 포함하는 경피 전달 시스템.
- 제18항에 있어서, 접착제층이 제1 접착제층을 포함하고, 후면층과 중합체 막 사이에 배치된 제2 접착제층을 포함하는 경피 전달 시스템.
- 제18항에 있어서, 중합체 막은 유체 매질 보유능이 5 mg/10 ㎠를 초과하는 경피 전달 시스템.
- 제23항에 있어서, 유체 매질이 단쇄 알콜을 포함하는 경피 전달 시스템.
- 제18항에 있어서, 접착제층이 아크릴, 실리콘, 고무, 스티렌-부타디엔 고무 및 폴리이소부틸렌으로 구성된 군중에서 선택된 감압 접착제를 포함하는 경피 전달 시스템.
- 제25항에 있어서, 감압 접착제가 아크릴-비닐 아세테이트 수지를 포함하는 경피 전달 시스템.
- 제18항에 있어서, 중합체 막이 친수성 또는 소수성 중합체 또는 공중합체를 포함하는 경피 전달 시스템.
- 경피 전달 시스템을 환자의 피부 또는 점막에 부착시키기 위한 접착제층을 준비하는 단계,중합체 막을 제공하는 단계,중합체 막을 통한 환자의 피부 또는 점막으로의 활성제의 전달율을 변경시키기 위해 중합체 막에 소정량의 유체 매질을 함침시키는 단계,중합체 막의 건조없이 상기 접착제층을 건조시키는 단계,접착제층을 상기 함침된 중합체 막에 도포하는 단계,후면층을 제공하고 상기 접착제층 및 상기 중합체 막을 상기 후면층에 도입하는 단계; 및환자의 피부 또는 점막에 경피 전달 시스템을 적용하기 전에, 접착제층을 보호하기 위해 상기 접착제층에 인접하여 박리 라이너를 제공하는 단계를 포함하는, 활성제를 환자에게 전달하기 위한 경피 전달 시스템을 제조하는 방법.
- 제28항에 있어서, 유체 매질이 활성제용 용매, 활성제용 증강제, 활성제용 부형제 및 활성제로 구성된 군중에서 선택된 액체를 포함하는 방법.
- 제28항에 있어서, 접착제층이 제1 접착제층을 포함하고, 후면층과 중합체 막 사이에 제2 접착제층을 도포하는 단계를 포함하는 방법.
- 제30항에 있어서, 제1 및 제2 접착제층이 아크릴, 실리콘, 폴리이소알칼리류, 고무, 비닐 아세테이트, 폴리이소부틸렌 고무, 폴리부타디엔, 스티렌-부타디엔, 셀룰로스 유도체, 다당류, 폴리우레탄 탄성중합체 및 폴리에스테르 탄성중합체로 구성된 군중에서 선택된 접착제를 포함한 접착 매트릭스를 포함하는 방법.
- 제29항에 있어서, 유체 매질이 활성제용 용매를 포함하는 방법.
- 제32항에 있어서, 활성제용 용매가 C2-C18 알콜을 포함하는 방법.
- 제31항에 있어서, 제1 접착제층에 활성제를 첨가하는 단계를 포함하는 방법.
- 제31항에 있어서, 제2 접착제층에 활성제를 첨가하는 단계를 포함하는 방법.
- 제31항에 있어서, 제1 및 제2 접착제층에 활성제를 첨가하는 단계를 포함하는 방법.
- 제28항에 있어서, 중합체 막이 친수성 및 소수성 중합체 및 공중합체로 구성된 군중에서 선택된 중합체를 포함하는 방법.
- 제37항에 있어서, 중합체가 폴리올레핀, 에틸렌-비닐 아세테이트, 폴리비닐 아세테이트, 폴리에테르 블록 아미드, 폴리우레탄, 폴리아미드, 셀룰로스, 셀룰로스 유도체, 폴리비닐 클로라이드, 폴리비닐 알콜, 폴리스티렌, 폴리메틸 메타크릴레이트, 폴리실란 및 폴리실록산으로 구성된 군중에서 선택되는 방법.
- 제28항에 있어서, 액체 조성물의 소정량이 0.5 내지 10 mg/㎠를 포함하는 방 법.
- 제39항에 있어서, 액체 조성물의 소정량이 1 내지 7 mg/㎠를 포함하는 방법.
- 제40항에 있어서, 액체 조성물의 소정량이 약 3.0 mg/㎠를 포함하는 방법.
- 제30항에 있어서, 제1 및 제2 접착제층이 활성제용 용매에 의한 가소화에 적어도 부분적으로 내성인 접착제를 포함하는 방법.
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US11/062,084 | 2005-02-18 | ||
US11/062,084 US20060188558A1 (en) | 2005-02-18 | 2005-02-18 | Transdermal systems having control delivery system |
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KR20070103038A true KR20070103038A (ko) | 2007-10-22 |
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US (3) | US20060188558A1 (ko) |
EP (1) | EP1848412A2 (ko) |
JP (1) | JP2008530217A (ko) |
KR (1) | KR20070103038A (ko) |
AU (1) | AU2006216955B2 (ko) |
CA (1) | CA2598308C (ko) |
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EP2041214A4 (en) | 2006-07-10 | 2009-07-08 | Medipacs Inc | SUPERELASTIC EPOXY HYDROGEL |
EP2227635A2 (en) | 2007-12-03 | 2010-09-15 | Medipacs, Inc. | Fluid metering device |
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-
2005
- 2005-02-18 US US11/062,084 patent/US20060188558A1/en not_active Abandoned
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2006
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- 2006-02-14 KR KR1020077018841A patent/KR20070103038A/ko active Search and Examination
- 2006-02-14 MX MX2007010055A patent/MX2007010055A/es active IP Right Grant
- 2006-02-14 CA CA2598308A patent/CA2598308C/en not_active Expired - Fee Related
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- 2006-02-14 EP EP06735082A patent/EP1848412A2/en not_active Withdrawn
- 2006-02-14 AU AU2006216955A patent/AU2006216955B2/en not_active Ceased
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2009
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2015
- 2015-04-30 US US14/700,316 patent/US20150246006A1/en not_active Abandoned
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US20090234308A1 (en) | 2009-09-17 |
JP2008530217A (ja) | 2008-08-07 |
WO2006091442A2 (en) | 2006-08-31 |
EP1848412A2 (en) | 2007-10-31 |
AU2006216955B2 (en) | 2011-02-10 |
US20060188558A1 (en) | 2006-08-24 |
MX2007010055A (es) | 2007-10-16 |
AU2006216955A1 (en) | 2006-08-31 |
US20150246006A1 (en) | 2015-09-03 |
CA2598308A1 (en) | 2006-08-31 |
CA2598308C (en) | 2012-05-01 |
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