KR20040101992A - 간 질환에서의 유전자 발현 프로파일 - Google Patents

간 질환에서의 유전자 발현 프로파일 Download PDF

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KR20040101992A
KR20040101992A KR10-2004-7009882A KR20047009882A KR20040101992A KR 20040101992 A KR20040101992 A KR 20040101992A KR 20047009882 A KR20047009882 A KR 20047009882A KR 20040101992 A KR20040101992 A KR 20040101992A
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genes
liver
gene
expression
liver cancer
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고상석
리우킹
정현호
젱웬
이복만
웨라밀리수브라매니암
송시용
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엘지 바이오메디컬 인스티튜트
진 로직 아이엔씨
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    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
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Abstract

본 발명은 암화 간 조직과 병에 걸렸지만 암화되지 않은 조직에서 다르게 발현되는 유전자들을 확인하기 위하여 간 종양으로부터의 조직을 검사함으로써 얻어진다. 본 발명은, 차등 발현된 유전자들에 상보적이거나 또는 그것에 혼성화되는 올리고뉴클레오티드 어레이를 포함하는 것으로 구성된 고체 지지체뿐만 아니라, 상기 유전자들을 이용하여 진단하는 방법, 약제 설계를 모니터링하는 방법 및 치료방법들 포함하고 있다.

Description

간 질환에서의 유전자 발현 프로파일 {GENE EXPRESSION PROFILES IN LIVER DISEASE}
간 질환
일반적으로, 간 질환은 간이 고장(malfunction)을 일으키거나 또는 기능이 거의 정지되게 하는 장애(disorder)로 분류된다. 예를 들어, 간 경화(cirrhosis)는 간세포가 손상된 조직으로 대체되어 정상 간 조직의 량을 감소시키는 만성적 간 질환의 한 종류이다. 이러한 질환은 가장 일반적으로는 알코올 중독에 의해 야기됨에 반하여, 간염에 의한 감염 및 다른 담즙 질환을 앓는 환자들도 간 경화로 질행될 수 있다. 만성 B형 간염, C형 간염 및 간 경화는 비록 이들의 기작이 완전히 밝혀진 것은 아니지만 원발성 간암(primary liver cancer)과 깊은 관련이 있어 보인다 (Wuet al.(2001), Oncogene,20;3674-3682). 약 10-20%의 만성 B형 간염이원발성 간암을 유발한다. 또한, 알코올의 소비, 불충분한 영양섭취, 아플라톡신(aflatoxin)(피넛, 콩, 곡물 및 종자와 같은 발아식품에서 발견되는 곰팡이류에 의해 생성되는 발암물질) 등과 같은 기타 요소들도 원발성 간암 및 간 경화의 진행과 관계가 있다.
원발성 간암에서, 간세포는 비정상적이 되고 제어가 되지 않는 성장으로 악성 종양을 형성한다. 이러한 질환은 또한 간세포암(Hepatocellular carcinoma; HCC) 또는 악성 간암(Hepatoma)이라 부른다. 전이의 결과로서 종양의 신체의 다른 부위로부터 간으로 퍼진 암은 동일한 질환은 아니다. HCC는 그 증상이 특이적이지 않기 때문에 증상 초기 단계에는 탐지하기 어렵다. 이들 증상으로는 식욕 저하, 체중 감소, 발열, 피로 및 허약 등이 있다. 암이 진행됨에 따라, 고통은 상 복부에서 등과 오른쪽 어깨까지 미친다. 소변 및 황달과 함께, 팽윤되어 있거나 촉진(觸診)될 수 있는 덩어리가 상 복부에 존재할 수도 있다. 종양이 전이 될 때, 그것은 통상적으로 폐와 뇌를 표적으로 한다.
HCC의 진단은 혈액검사로 행해질 수도 있는데, 특히 알파-페토프로틴(α-fetoprotein)이 표적마커로 이용된다. HCC 환자의 약 50-70%가 알파-페토프로틴의 수치가 증가되는 양상을 보인다. 또 다른 진단 방법으로는, 비방사능 영상화(복부 또는 가슴의 X선 촬영, 혈관 조영술, CT 스캔, MRI), 방사능 물질과 생체 조직을 이용한 간 스캔 등이 있다. HCC의 치료는 그것의 탐지가 너무 늦은 경우 종종 성공적이지는 못하지만, 치료 방법으로는 화학적, 방사능적 또는 이들의 조합으로 종양을 외과적으로 제거하는 방법이 있다. 비록 HCC는 미국에서 보편적이지는 않지만, 간염 바이러스에 감염될 확률이 높은 아시아와 아프리카의 일부 지역에서 매우 빈번하다(http://cis.nci.nih.gov/;http://cancer.med.upenn.edu/disease/liver/intro_liver.html).
미국에서는 매년 대략 200,000 개의 급성 및 만성 바이러스 간 질환의 새로운 케이스들이 보고되고 있다. 이러한 간 질환을 보편적으로 유발하는 바이러스는 A형 바이러스, B형 바이러스(또한 종양 유발성), D형 바이러스(δ바이러스, B형 간염 바이러스 존재시에만 감염되는 "손상된" RNA), C형 바이러스, E형 바이러스(또는 유행성 비 A, 비 B 간염), F형 바이러스 및 G형 바이러스(B형 바이러스의 돌연변이일 수 있지만 B형 항원을 발현하지 않는, 유행성 비 A, 비 B, 비 C 바이러스 변이체들), 세포확대바이러스(cytomegalovirus), 엡스테인-바르 바이러스(Epstein-Barr virus) 및 단순포진바이러스(herpes simplex virus) 등이 있다. 마지막 세 개는 간, 신장, 골수 이식에 따르는 면역 억제 치료를 받은 환자에게서 두드러진다. 일반적으로, B, C 및 D형 간염 바이러스는 만성 바이러스 간염과 관련이 있다.
간염 바이러스 중, B형 바이러스는 사망률과 크게 관련이 있다. 이러한 바이러스는 내인성 DNA 중합효소(endogenous DNA polymerase) 및 길이에서 DNA 3200 염기 쌍의 단일, 환형 분자를 가진 이중-셸(shelled) DNA 이다. 이러한 바이러스는 역전사 효소를 필요로 하는 RNA 중간체를 통해 복제된다. B형 간염 환자에서는, 혈청에서, 20 nm의 구형, 직경 20 nm와 길이 100 nm의 관형, 및 42 nm의 데인(Dane) 입자의 관형 등 세 종류의 입자들이 탐지될 수 있다. 오리, 왜가리,다람쥐 및 마모트에서 발견되는 B형 간염 바이러스는 인간 B형 간염 바이러스와 유사하다.
일반적으로 B형 간염의 진단은 혈청안에 존재하는 표면 항원(HBsAG)을 탐지함으로써 수행된다. 여섯 달 또는 그 이상의 기간 동안 HBsAG의 존재는 수용체 단계 내지 만성 감염을 나타낸다. 항HBs(HBsAb)는 회복과 면역을 나타낸다.
비록 중심 항원(HBcAg)는 혈액내에서 탐지될 수 없지만, 항체가 탐지될 수 있다. 급성 간염의 경우에는, 중심 항원(HBcAg)의 IgM 항체가 발견된다. 하지만 이러한 항체가 계속 유지된다면, 만성 바이러스형 간염을 나타낸다. HBsAb가 아닌 HBsAg를 가지고 IgG HBcAb의 고 발현으로 인한 만성 감염의 여부를 알 수 있다.
HBeAg는 바이러스의 합성 및 감염과 관련이 있다. 항체 HBeAb의 출현은 감염의 감소의 신호이고, 환자는 곧 회복할 것이다.
B형 간염 바이러스에 감염된 성인의 약 2-8%만이 만성 B형 간염으로 진행되지만, 감염된 신생아의 약 90%는 운반체가 된다. 환자의 약 25%가 결국 간 경화로 발전되는 것처럼, 만성 B형 간염의 감염은 간암뿐만 아니라 간 경화와 관련이 있다. 비록 만성 및 급성 B형 간염 감염의 일반적으로 효과적인 치료는 없지만, 현재의 치료 방법은 인터페론 알파-2a를, 예를 들어, 10,000,000 units의 양으로 6주 동안 주 3회 투여하거나 또는 5,000,000 units의 양을 넉 달 동안 매일 투여하는 방법이다.
C형 간염 바이러스는 후기 이입 간염(post-transfusion hepatitis)의 주요 원인인 것으로 생각된다. 이러한 바이러스는, 30-60 nm의 입자들을 생산하는, 지질 외피 바이러스(lipid envelope virus)의 토가바이러스(togavirus)군으로 분류된다. 이들은 약 10.5 kb의 게놈을 가진 단일 가닥 RNA이다. C형 간염에 감염된 환자의 약 50%는 만성 감염으로 진행되고, 이들의 약 20%는 간경화로 진행된다. 상기에서 언급한 것과 같이, 많은 C형 간염 환자들은 간암으로 발전되지만, 그 백분율은 아직 정해지지 않은 상황이다. C형 간염을 치료하고자 하는 노력은, 알파 인터페론을 포함한, 현재의 항 바이러스가 효과적이지 않다는 결과로 인해 난항을 겪고 있다(http://www.arens.com/brian/viral.htm).
일반적으로 독소, 염증 또는 대사 이상으로 유발되는 간 경화는 섬유증(fibrosis)과 함께 널리 퍼진 결절(nodule)에 의해 특징지워진다. 손상되었거나 죽은 세포는 섬유성 반흔 조직(fibrous scar tissue)으로 대체되고 이는 섬유증(fibrosis)로 발전한다. 간세포는 비정상적인 형태로 재생되어, 섬유성 조직에 의해 둘러싸여진 결절을 형성한다. 이러한 섬유증과 결절의 형성은 간의 조직구조 성분들의 왜곡 및 패쇄를 유발하여, 손상된 혈액 흐름 및 생화학적 기능을 유발한다.
순환계에서, 장과 췌장으로부터 나온 혈액은, 간정맥을 통해 심장으로 되돌아가기 전에 간 문맥을 통해 간으로 유입된다. 또한 혈액은 직접적으로 간 동맥으로부터 간으로 유입된다. 식도, 위, 소장 및 직장에서, 신체의 전신 순환은 간 문맥 순환에 연결되고, 정상 조건에서는 간 문맥 순환에서 전신 순환으로의 역류는 존재하지 않는다. 하지만 간 경화에 있어서, 섬유성 반흔 조직(fibrous scar tissue)은 간 조직으로 그리고 간을 통과하는 혈류를 감소시킨다. 그런 다음, 혈액은 간 문맥과 문맥 순환에서 역류하여, 고립된 혈액세포, 혈소판의 감소 및 비정상적인 출혈에 의한 비장의 팽창과 같은, 다른 기관들에 합병증을 유발한다. 혈액의 전신 순환으로의 역류는, 과도한 파열과 출혈을 유발할 수 있는, 식도, 위 및 직장에서 이상 확장 정맥(varicose vein)을 유발할 수 있다. 문맥 순환에서의 고혈압은 복부(복수:ascite)와 주변조직(말초 부종:peripheral edema)의 장액성 액체의 축적을 유발할 수 있고, 반면 감소된 빌리루빈(bilirubin) 분비는 혈액과 황달의 빌리루빈 수치를 증가시킬 수 있다. 간 경화로 인한 비정상적인 생화학적 변화에는, 알부민의 수치(복수와 부종을 더욱 악화시킨다)와 혈액 응고 인자의 감소를 유발하고, 남성유방의 여성화(gynecomastia: 에스트로겐 대사의 이상)와, 당, 트리글리세리드, 콜레스테롤 대사 감소 등이 포함된다. 간 경화가 진행된 단계에서는, 간의 해독작용에 의해 보통은 제거되는 독성물질이 뇌로 흘러 들어가기 때문에 뇌의 이상을 초래할 수 있다. 이러한 변화로는 정신적 기능(집중 및 인지 능력)의 이상, 혼수, 가사, 뇌의 팽창 및 사멸 등이 있다.
상기의 증상을 보이는 환자에 있어서, 간 경화의 진단은 일반적으로 간단하지만, 초기 단계에 이를 탐지하기 어려울 수도 있다. 초기 단계에서 나타나는 미묘한 변화로는 손바닥의 붉어짐, 상체의 홍점, 이하선(耳下腺)의 비대증, 손바닥 힘줄들의 섬유증, 지네코마스시아(gynecomastia) 등이 있다. X선과 방사능 치료가 효과적일 수도 있으나, 진단은 종종 간 생검에 의해 수행되어야 한다.
질환의 진행(특히 알콜 중독)을 중지시키기 위하여 근본적인 원인들이 치료될 수도 있지만, 간의 구조적 손상은 비가역적이다. 질환의 후유증(이상 확장 정맥, 복수 및 부종과 같은)이 또한 치료될 수도 있다. 장기간 음주를 중단한 알콜중독 환자에게서, 간이식은 성공적이었다(http://cpmcnet.columbia.edu/dept/gi/cirrhosis.html)
간암에서의 분자적 변화
위 세포에서 간암으로의 발전가능성 및 진행과 관련한 분자학적인 변화에 관해서는 알려진 것이 거의 없다. 그러므로, 간암으로의 발전과 진행과 관련한 새로운 분자상의 마커(marker)의 확인과 또한 유전자 수준에서의 발현 변화의 조사가 필요한 실정이다. 더욱이, 만약 외과적 수술이 간암의 진행을 성공적으로 중지시키거나 더디게 할 수 있다면, 이러한 질병의 초기 임상적 증후를 정확하게 접근할 수 있는 수단의 확립이 필요하다. 이러한 간암의 조기진단을 정확하게 판별할 수 있는 한가지 방법은 질병진행과 유일하게 관련이 있는 마커를 규명하는 일이다 (Kimet al., Oncogene20;4568-4574,2001). 마찬가지로, 간암의 진행을 중지시킬 수 있는 치료학적인 방법은 간 조직에서 종양성을 가진 세포로 형질전환 및 성장할 수 있는 가능성을 가진 유전자를 규명하는 데에 달려있다.
연구자들은 종양 형성의 원천이 되는 것으로 믿어지는 몇몇 유전적 변이(또는 유전자 변화)를 규명할 수 있었다. 이러한 유전자 변화는 종양유발유전자(oncogene)의 증폭과 종양 억제 유전자(tumor suppress gene)의 소실을 초래하는 돌연변이를 포함하고 있다. 종양 억제 유전자란 비정상적인 세포의 성장을 억제하는 단백질을 천연형 대립형질(wild-type allele)에서 발현시킬 수 있는 유전자를 말한다. 종양 억제 단백질을 암호화하는 유전자가 변이되었거나 소실되었을 경우, 결과적인 돌연변이 단백질이나 종양 억제 단백질 발현의 완전한 결실로 인해 정상적인 세포성장을 정확하게 조절하지 못할 수도 있고, 특히 세포성 조절 기작에 이미 문제가 있는 경우에는 비정상적인 성장이 일어날 수도 있다. 이미 잘 알려진 많은 수의 인간 종양이나 암 세포주는 종양 억제 유전자를 결실하고 있거나 그 기능이 소실되어 있는 경우이다. 종양 억제 유전자의 예로는, 다음의 것으로 한정되는 것은 아니지만, 망막아세포종 민감성 유전자(retinoblastoma susceptibility gene) 또는 RB 유전자, p53 유전자, Deletion in Colon Carcinoma(DCC), 신경 섬유종 타입 1 종양 억제 유전자(neurofibromatosis type 1(NF-1) tumor suppress gene) (Weinberg,Science254:1138-1146, 1991) 등이 있다. 종양 억제 유전자의 기능의 상실이나 불활성화는 상당히 많은 수의 인간 종양의 개시와 이의 진행에 중요한 역할을 할 수 있다.
종양의 이종 집단들을 분류하는 것은 불굴의 노역이다; 그래도, 종양의 아형을 확인하기 위하여 유전자 발현 형태를 이용한 초기의 연구는 흥미로운 결과를 낳았다 (Perouet al., Proc Natl Acad Sci U S A96:9212-9217,1999;Golubet al., Science286; 531-537, 1999; Alizadehet al., Nature403;503-511,2000; Alonet al. Proc Natl Acad Sci U S A96:6745-6750,1999; and Bittneret al., Nature406;536-540,2000). 유전자 발현 프로파일에 의한 B-세포 림프종(B-cell lymphoma)의 분자학적 분류는 임상학적으로 구별되는 산재한 많은 B-세포 림프종 아형그룹(subgroup)들을 밝혀내었다 (상기 Alizadeh 참조). 연구자들은, 뚜렷한유전자 발현 프로파일에 기초한 환자들의 분류에 의해, 화학요법제를 평가하기 위한 유사한 환자군들을 정밀하게 그룹화할 수도 있다. 더욱 동질의 환자 개체군은 환자 개개의 반응의 다변성을 감소시킴으로써, 기존에 알려져 있지 않은 특정 아종 암들을 근절시킬 수 있는 약제를, 표준 분류 기법을 사용하여 개발할 수 있도록 해 준다.
종양을 분류하고, 약제의 표적을 확인하고, 진단 마커를 확인하고 및/또는 화학요법의 결과를 더욱 간파하기 위하여 유전자 발현 프로파일을 사용하는 것은, 다양한 암들을 치료하기 위한 더욱 효과적인 환자 특이적 전략의 설정을 용이하게 할 수 있다. 유방암에 있어서, 한정된 수의 유전자(8,102 유전자)를 이용하는 연구는 종양들을 유전자 발현 프로파일에 근거하여 아형들로 분류하였고, 이러한 연구는 유방암과 관련되어있는 다양한 분자학적 표현형들을 밝혀 주었다 (Perouet al., Nature406:747-752, 2000). cDNA 와 올리고뉴클레오티드 어레이의 출현으로 수 천 종류의 유전자에 대한 조직-특이적 발현 레벨을 매핑(mapping)할 수 있게 되었다.(Alonet al., Proc Natl Acad Sci USA96:6745-6750, 1999; Iyeret al., Science283:83-87, 1999; Khanet al., Cancer Res58:5009-5013, 1998; Leeet al., Science285;1390-1393, 1999; Wanget al., Gene229;101-108, 1999; Whitneyet al., Ann Neurol46:425-428, 1999). Martinet al.,(Cancer Res:60;2232-2238, 2000)의 연구에서는, 정상 유방 상피세포와 관련한 차등 표시(differential display)에 의해 또는 MDA-MB-435 악성 유방 종양 세포주로부터 발견된 124 개의 유전자로 구성된 커스텀 마이크로어레이(Custom microarray)를 사용하였다. 커스텀 마이크로 어레이를 사용함으로써, 연구자들은 유방암의 임상 단계를 가지고 수많은 유전자들을 나눔으로써 발견된 발현 패턴들 사이의 관계를 실험하여, 유전자 발현 패턴에 의해 유방 종양들을 구별되는 카테고리로 그룹화할 수 있다는 것을 확인하였다 (상기 Martin et al., 참조).
비록 이러한 연구로 인해 유전자 발현 프로파일이 종양과 같은 인간 질병에 대한 진단을 향상시키고, 치료요법의 단계를 개선시켰다 하더라도, 더 많은 연구가 필요하다. 따라서, 간암의 더욱 정확한 진단을 가능케 하는 물질과 방법에 대한 필요성이 당업계에 존재하다. 또한, 이러한 질환을 효과적으로 치료하는 방법과 약제를 규명하는 방법에 대한 필요성이 당업계에 존재한다. 본 발명에서는 이러한 필요성과 기타 필요성을 만족시킨다.
본 발명은 간암 환자의 간조직에서 유전자 발현의 변화에 관한 것이다. 본 발명은 상세하게는, 발병된 그러나 비발암성의 간조직과 비교하여 발암성 간 조직에서 다르게 발현된 인간 유전자들에 관한 것이다.
본 발명은 다양한 유형과 단계의 간 질환, 특히, 간세포암(HCC), 만성 간염(CH) 및 간 경화(LC)와 관련한 유전자들 및 이들의 발현 프로파일들의 발견에 근거하고 있다.
본 발명은, 유전자들의 차등 발현(differential expression)이 간 질환임을 나타내는 표 1 에 기재되어 있는 하나 또는 그 이상의 유전자들의 발현 레벨을 조직으로부터 검출하는 단계를 포함하는 것으로 구성되어 있는, 환자에게서 간 질환을 진단하는 방법을 포함하고 있다. 본 발명은 또한 간 질환의 진행을 검출하는 방법을 포함하고 있다. 예를 들어, 본 발명은, 유전자들의 차등 발현이 간 질환의진행을 나타내는 표 1 에 기재되어 있는 하나 또는 그 이상의 유전자들의 발현 레벨을 조직으로부터 검출하는 단계를 포함하는 것으로 구성되어 있는, 환자에게서 간 질환의 진행을 진단하는 방법을 포함하고 있다. 바람직한 실시예에서, 표 1 에 기재되어 있는 유전자의 일부분 또는 전체에 기반한 PCA 분석은, 간암의 전이에서와 같은, 간 질환들의 서로다른 단계간을 차등화하기 위하여 사용될 수도 있다. 바람직한 실시예에서 표 1로부터의 하나 또는 그 이상의 유전자들이 선택될 수도 있다.
하나의 측면에서, 본 발명은, 간 질환 환자의 치료를 모니터링하고, 간 질환 환자에게 약제 조성물을 투여하고, 간 질환 환자로부터 수거한 조직이나 세포로부터 유전자 발현 프로파일을 제작하고, 환자 유전자 발현 프로파일을, 정상 간 세포들로 구성된 세포 군체로부터의 유전자 프로파일이나, 병든 간 세포들로 구성된 세포 군체로부터의 유전자 프로파일이나, 또는 이들 모두와 비교하는 방법을 제공한다. 바람직한 실시예에서, 유전자 프로파일은 표 1에서의 하나 또는 그 이상의 유전자들의 발현 레벨을 포함할 것이다.
본 발명의 또 다른 측면은, 표 1에서의 적어도 하나의 유전자의 발현을 변경하는 약제 조성물을 환자에게 투여하고, 병든 질병을 포함하고 있는 환자의 세포나 조직 샘플로부터 유전자 발현 프로파일을 제작하고, 상기 환자 발현 프로파일을 병든 간세포들을 포함하고 있는 치료하지 않은 세포 군집으로부터 유전자 발현 프로파일과 비교하는 것을 포함하는 것으로 구성되어 있는, 간 질환 환자를 치료하는 방법을 포함하고 있다.
또 다른 측면에서, 본 발명은, 유전자들의 차등 발현이 간 발암 현상(hepatic carcinogenesis)을 나타내는 표 1에서의 하나 또는 그 이상의 유전자의 발현 레벨을 조직 샘플에서 검출하는 것을 포함하는 것으로 구성되어 있는, 발암 현상의 진행을 환자에게서 검출하는 방법을 제공한다.
본 발명은 또한, 간 질환의 개시 또는 진행을 조절할 수 있는 작용제(agent)에 세포를 노출시키는 단계, 및 표 1에서의 하나 또는 둘 이상의 유전자들의 발현 수준을 검출하는 단계를 포함하는 것으로 구성된, 상기 작용제를 스크리닝하는 방법을 제공한다. 바람직한 실시예에서, 간 질환은 세포성 간암일 수 있다. 바람직한 실시예에서, 하나 또는 그 이상의 유전자들은 표 1에 기재되어 있는 유전자들로 구성된 군으로부터 선택될 수 있다. 바람직한 실시예에서, 표 1의 유전자 전부 또는 거의 전부를 검출하는 것이 바람직할 수 있다.
본 발명은 또한, 각각의 프로브(probe)가 표 1에서의 유전자에 특이적으로 혼성화되는 서열을 포함하고 있는 적어도 2 개의 프로브를 포함하는 것으로 구성된 고체 지지체(solid support) 뿐만 아니라, 각각의 올리고뉴클레오티드가 표 1에서의 유전자에 특이적으로 혼성화되는 서열을 포함하고 있는 적어도 2 개의 올리고뉴클레오티드를 포함하는 것으로 구성되어 있는 조성물을 포함하고 있다. 바람직한 실시예에서, 하나 또는 그 이상의 유전자들은 표 1에 기재되어 있는 유전자들로 구성된 군으로부터 선택될 수 있다.
본 발명은 또한, 표 1에서의 적어도 두 개의 유전자를 포함하는 유전자 세트의 발현 레벨을 간 조직에서 확인하는 정보를 포함하고 있는 데이터베이스와 이 정보를 보기 위한 사용자 인터페이스(user interface)를 포함하는 것으로 구성되어 있는 컴퓨터시스템을 포함한다. 바람직한 실시예에서, 하나 또는 그 이상의 유전자들은 표 1에 기재되어 있는 유전자들로 이루어진 군으로부터 선택될 수 있다. 데이터베이스는 암화 간 조직과 비암화 간 조직에서 유전자 셋트의 발현 레벨을 확인하는, 유전자들에 대한 서열 정보를 더 포함할 수 있고, GenBank와 같은 외부 데이터베이스에 대한 링크를 더 포함할 수 있다.
마지막으로, 본 발명은, 조직이나 세포에서 표 1에서의 적어도 하나의 유전자의 발현 레벨을 확인하는 정보를 제공하기 위해 공개된 컴퓨터 시스템을 사용하는 방법과 같이, 조직이나 세포에서 표 1에서의 적어도 하나의 유전자의 발현 레벨을 데이터베이스에서 유전자의 발현 레벨과 비교하는 단계를 포함하는 것으로 구성된, 데이터베이스를 사용하는 방법을 포함하고 있다.
[상세한 설명]
수많은 생물학적 기능들은 전사(예를 들어, 개시의 제어, RNA 전구체의 제공, RNA 프로세싱) 및/또는 해독 제어를 통한 다양한 유전자의 발현을 조절함으로써 달성된다. 예를 들어, 세포 주기, 세포 분화 및 세포 사멸과 같은 기본적인 생물학적 과정들은 유전자 집단의 발현 레벨에서의 변화에 의해 특징지워진다.
또한 유전자 발현의 변화는 질병 발생(pathogenesis)과도 관련이 있다. 예를 들어, 기능성 종양 억제 유전자의 발현이 충분하지 않거나 종양유전자/프로튼코진(oncogenes/protooncogene) 등의 과잉 발현은 세포의 성장을 과하게 만들거나 종양(tumorgenesis)으로의 발전 가능성이 있다(Marshall,Cell64;313-326,1991;Weinberg,Science, 254;1138-1146, 1991). 따라서, 특수한 유전자들(예를 들어, oncogenes 또는 tumor suppressor)의 발현 레벨의 변화는 다양한 질병의 발생 및 진행에 표지로서 작용한다.
유전자 발현의 변화를 모니터링하는 것은 약제의 검색이나 개발 중에 어떠한 잇점을 제공할 수도 있다. 종종 약제들은 주변의 세포에 다른 영향을 미치지 않으면서 주요 표적과 반응하기 위한 가능성을 미리 알아보기 위한 과정을 거친다. 이러한 다른 효과들은 전체 동물에서 독성을 야기하기도 하는데, 이는 잠재적인 약제의 개발 및 사용을 방해한다.
출원인들은, 객체들로부터의 샘플들을 사용하여, 종양 생검과 주변의 비암화 조직간의 유전자 발현에서의 전반적인 변화를 확인하기 위하여, 병에 걸렸지만 암화되지 않은 간 조직과 암화 간직으로의 샘플을 검사하였다. 병에 걸렸지만 암화되지 않은 간 조직은, 만성 간염 환자의 염증 조직이나 간 경화 환자의 섬유화 조직이었다. 비암화 조직은 종양 생검 위치에 인접한 간에서의 한 지점으로부터 얻었다. 유전자 발현의 이들 일반적인 변화는 발현 프로파일(expression profile) 이라고도 명하는데, 질병의 상태, 질병의 진행, 약제의 독성, 약제의 효능 및 약제의 대사를 모니터할 수 있는 마커(marker)로 사용될 수 있으며 또한 진단의 마커로도 사용될 수 있다.
여기에 기재되어 있는 유전자 발현 프로파일은 34-65 세까지의 한국인들의 병든 간 생검 샘플들로부터 얻어졌다. 이들 환자들은 만성 간염 또는 간 경화로 진단되었고, 각각의 경우에 있어서, 간암으로 발전하였다. 각 샘플과 관련한 질병의 상태는 표 2에 개시되어 있다.
본 발명은 세포의 상태, 즉, 비암화 상태와 암화 상태에 따라 다르게 발현될 수 있는 유전자 발현 레벨을 탐지할 수 있는 방법 및 조성물을 제공한다. 이러한 유전자 발현 프로파일은 독성, 약제 효능, 약제 대사, 진행 및 질병 모니터를 평가하기 위한 분자적 도구를 제공한다. 베이스라인 프로파일로부터의 유전자 발현 프로파일의 변화는 이러한 효과의 표식자로 사용될 수 있다. 당업자들은, 관심있는 조직이나 샘플에서의 유전자 발현 프로파일의 변화를 관측하기 위하여, 본 출원에서 확인된 하나 또는 그 이상의 유전자 및/또는 유전자 단편의 발현을 평가하기 위한 다양한 공지 기술들을 사용할 수 있다.
정의
하기의 설명에는, 당업자에게 공지되어 있는 수많은 용어들과 구절들이 뒤따른다. 해석의 명료함과 일관성을 위하여, 일부 용어들와 구절들의 정의를 제공한다.
여기에서 사용된, 구절 "발현의 레벨을 탐지하는 것(detecting the level of expression)"은 관심있는 유전자가 모두 발현되었는지를 결정하는 방법뿐만 아니라 발현 레벨을 정량화하는 방법을 포함한다. 따라서, 발현량을 반드시 제공할 필요없이 발현 여부의 결과만을 제공하는 평가는 여기에 사용된 구절인 "발현의 레벨을 탐지하는 것"을 필요로 하는 평가이다.
여기에서 사용된, 하나 또는 그 이상의 유전자에 상보적인 올리고뉴클레오티드 서열은, 엄격한 조건하에서 상기의 유전자의 뉴클레오티드 서열이 적어도 일부에 혼성화될 수 있는 올리고뉴클레오티드를 일컫는다. 이러한 혼성화 가능한 올리고뉴클레오티드들은 통상적으로 상기 유전자에 대해 뉴클레오티드 레벨에서 적어도 약 75%의 서열 상동성, 바람직하게는 약 80% 내지 85%의 서열 상동성, 더욱 바람직하게는 90% 내지 95% 또는 그 이상의 서열 상동성을 나타낼 것이다.
"실질적으로 결합한다(bind substantially)"는 프로브 핵산과 표적 핵산 사이의 상보적인 혼성화를 의미하며, 표적 폴리뉴클레오티드 서열의 소망하는 탐지를 달성하기 위하여 혼성화 배지의 가혹한 조건을 감소시킴으로써 수반될 수 있는 최소의 불일치(mismatch)를 포함한다.
"배경"(background) 내지 "배경 신호 강도"(background signal intensity)"는 표지된 표적 핵산과 올리고뉴클레오티드 어레이의 구성물(예를 들어, 올리고뉴클레오티드 프로브, 제어 프로브, 어레이 기질 등)들 간의 비특이적 결합 또는 기타의 상호작용들로부터 초래되는 혼성화 신호를 말한다. 배경 신호들은 어레이 구성물 자체의 내재적인 형광에 의해 생겨날 수도 있다. 단일 배경 신호가 전체 어레이에 대해 계산될 수 있고, 또는 차이있는 배경 신호가 각각의 표적 핵산에 대해 계산될 수도 있다. 바람직한 실시예에서, 배경 신호는 어레이의 프로브에서 최하 5%에서 10%, 또는 차이있는 배경 신호가 각 유전자에 대해 계산되는 경우에는, 각 유전자에 대해 프로브들의 최저 5%에서 10%에 대한 평균 혼성화 신호 강도로서 계산된다. 물론, 당업자들은, 특정 유전자에 대해 프로브가 잘 혼성화되고 따라서 특정 유전자에 특이적으로 결합하는 것으로 나타나는 경우, 이들은 배경 신호 계산에 사용되지 말아야 됨을 인식하게 될 것이다. 또는, 샘플에서 발견된 어떠한 서열에 상보적이지 않은 프로브(예를 들어, 반대 의미의 핵산, 또는 샘플이 포유류 핵산인 박테리아 유전자와 같은 샘플에서 발견되지 않는 유전자들에 대한 프로브)에 대한 혼성화에 의해 생산되는 평균 혼성화 신호 강도로서 계산될 수도 있다. 배경은 또한 프로브가 없는 어레이 부분에 의해 생산된 평균 신호 강도로서 계산될 수 있다.
"특이적으로 결합한다(hybridizing specifically)"는, 염기 서열이 복합 혼합 (예를 들어, 전체 세포) DNA 또는 RNA에 존재할 때, 특정 뉴클레오티드 서열 또는 서열들에 대한 또는 오직 그것에 대한 분자의 결합, 결합, 이중결합(duplexing) 및 혼성화(hybridization)를 의미한다.
본 발명의 분석과 방법은 적어도 100 개, 바람직하게는 약 1000 개, 더욱 바람직하게는 약 10,000 개 및 1,000,000 개 또는 그 이상의 서로 다른 핵산 혼성화를 동시에 스크리닝하는데 유용한 포맷을 이용할 수도 있다.
"불일치 제어(mismatch control)" 또는 "불일치 프로브"(mismatch probe)"는 서열이 특정 표적 서열에 완벽히 상보적이지 못하게 고의적으로 선택된 프로브를 의미한다. 고 집적 어레이(high-density array)의 각각의 불일치(또는 비결합, mismatch: MM) 대조군에 대해, 특정 표적 서열에 완벽히 상보적인 대응하는 완벽한 일치(또는 완벽한 결합, perfect match: PM)의 프로브가 통상적으로 존재한다. 불일치는 표적 서열의 대응 염기들에 상보적이지 않은 하나 또는 그 이상의 염기들로 구성될 수 있다.
불일치는 불일치 프로브의 어느 부분에나 존재할 수 있는 반면, 말단 불일치는 표적 서열의 혼성화를 덜 방해할 것으로 같으므로 말단 불일치는 덜 바람직하다. 특정 실시예에서는 불일치가 프로브의 중앙 내지 중앙 근처에 존재하기 때문에, 시험 혼성화 조건에서 표적 서열과의 이중결합을 가장 불안정하게 할 것으로 예상된다.
용어 "완전 일치 프로브(perfect match probe)"는 특정 표적 서열과 완전히 상보적으로 결합한 서열을 가진 프로브를 의미한다. 시험 프로브(test probe)는 표적 서열의 일부분(서브시퀀스)에 통상적으로 상보적으로 결합한다. 완전 일치(PM) 프로브는 "시험 프로브(test probe)", "표준화 제어 프로브(normalization control probe)", "발현 레벨 제어 프로브(expression level control probe)" 등이 될 수 있다. 그러나 완전 일치 제어(perfect match control) 및 완전 일치 프로브(perfect match probe)는 불일치 제어(mismatch control) 및 불일치 프로브(mismatch probe)와 구별된다.
여기서 사용된 "프로브(probe)"는 핵산과 동일하며, 바람직하게는, 수소결합 및 상보적 염기와 쌍을 이루는 것과 같은 하나 또는 그 이상의 화학결합을 통해 표적 핵산의 상보적 서열에 결합할 수 있는 올리고뉴클레오티드를 의미한다. 여기서 사용된 것처럼, 프로브는 본래의 염기(즉, 아데니, 구아닌, 우라민, 시토신 및 티민) 내지 변형된 염기(7-deazaguanosine, inosine, 등)가 포함될 수 있다. 게다가, 프로브의 염기는 혼성화에 방해하지 않는 한, 포스포다이에스터 결합이 아닌 다른 결합에 의해 형성될 수도 있다. 따라서, 프로브를 구성하는 염기는 포스포다이에스터 결합보다는 펩티드 결합에 의해 구성 염기들이 결합되는 펩티드 핵산일 수 있다.
용어 "스트린전트 조건(stringent condition)"이란 프로브가 표적 서열과 혼성화되는 조건을 의미하지만, 차이가 확인될 수 있게 다른 서열과의 약한 결합이 될 수도 있다. 스트린전트 조건은 서열 의존적이며 다른 환경 조건에서는 달라질 것이다. 긴 서열일 경우 더 고온에서 특이적으로 혼성화가 이뤄진다. 일반적으로, 스트린전트 조건은 정의된 이온 강도와 산도(pH)에서 특정 서열에 대한 융해점(Tm)보다 약 5℃가 낮게 선택된다.
통상적으로, 스트린전트 조건은, 짧은 프로브(예를 들어, 10에서 50개 염기)일 경우에, 염 농도가 pH 7.0 내지 8.3에서 적어도 0.01 내지 1.0 M의 나트륨(또는 다른 염) 이온 농도이고 온도가 적어도 약 30℃의 온도조건일 것이다. 또한, 스트린전트 조건은 포름아마이드와 같은 불안정한 시약의 첨가로 형성될 수도 있다.
"서열 상동성 백분율"("percentage of sequence identity") 또는 "서열 상동성(sequence identity)"은 비교 윈도우나 스팬상에서 두 개의 최적 배열 서열이나 연속서열을 비교하는 것을 의미한다. 여기에서 윈도우에서 비교한 폴리뉴클레오티드 서열의 부분은 두 개의 서열을 최적으로 정렬하기 위하여, 참고 서열(첨가나 소실이 포함되어 있지 않음)과 비교해 볼 때 부가 내지 소실(즉, gaps)이 포함될 수도 있다. 백분율은 두 서열간의 일치하는 위치의 숫자가 형성되는 동일한 하부단위(예를 들어, 핵산 염기 또는 아미노산 잔기)가 있는 위치의 수를 결정함으로써 계산되는데, 이는 일치하는 위치를 비교하려는 윈도우상의 전체의 위치의 수로 나누고 이에 100을 곱하여 서열 상동성 백분율을 나타낸다. 서열 상동성 백분율은, GAP 내지 BESTFIT(이하를 참조)의 프로그램을 사용하여 계산할 때, 디폴트 갭 웨이트(default gap weight)를 사용하여 계산된다.
서열 유사성 또는 상동성은 서열 상동성을 찾을 수 있도록 제작된blastp, blastn, blastx, tblastn 및 tblastx(Karlinet al.,Proc Natl Acad SciUSA 87:2264-2268,1990 그리고 Altschul,J Mol Evol36:290-300, 1993)와 같은 프로그램에서 사용되고 있는 알고리즘을 사용하는, 서열 BLAST(Basic Local Alignment Search Tool)분석법에 의해 측정될 수 있다. LAST 프로그램에 의해 사용되는 접근방법은, 검토할 서열과 데이터베이스 서열간의 서열 유사성에 우선 검토하고, 확인된 모든 서열의 통계학적인 의미를 평가한 다음, 최종적으로 기선정된 역치값을 만족하는 서열들을 요약하는 것이다. 서열 데이터베이스의 유사도를 찾는 과정의 논의는 Altschulet al.,(Nature Genet6:119-129,1994)에 기재되어 있으며 이는 참조로서 여기에 합체된다. 히스토그램, 설명, 서열의 정렬, 기대치(즉, 데이터베이스의 서열에 대한 대상 서열의 보고를 위한 통계학적으로 의미있는 역치값), 컷오프, 매트릭스 및 필터와 같은 파라미터 등은 디폴트 세팅에 있다. blastp, blastx, tblastn 및 tblastx에 의해 사용되는 디폴트 스코링 매트릭스(default scoring matrix)는 BLOSM62 매트릭스(Henikoffet al.,Proc Natl Acad SciUSA 89;10915-10919, 1992, 참조로서 합체됨)이다. 네 개의 blastn 매개변수들은 하기와 같이 정해졌다: Q=10(gap creation penalty); R=10(gap extension penalty);wink=1(문의사항에 따라 매 winkth마다 word hits을 형성함 :그리고 gapw=16(차이가 생긴 서열 내에 윈도우의 폭을 세팅). 동등한 Blastp 매개변수 세팅은 Q=9; R=2; wink=1 및 gapw=32이었다. GCG 패키지 버전 10.0에서 유용할 수 있는, 서열간의 최적 비교는 DNA 파라미터인 GAP=50(gap creation penalty)와 LEN=3(gap extension penalty)를 사용하며, 단배질 비교에서 균등한 세팅은 GAP=8 과 LEN=2 이다.
발현에 차이가 있는 유전자들의 사용
본 발명은 비암화 간 조직과 암화 조직에서 발현에 차이가 있는 유전자들을 확인하는 것이다. 당업자는 표 1에서 서로 다르게 발현되는 것으로 확인된 하나 또는 그 이상의 유전자를 선택할 수 있고, 특정 샘플을 조사 또는 확인하기 위하여 여기서 제공하는 정보와 방법을 사용할 수 있다. 두 종류의 조건과 소스의 특별한 확인을 위해, 두 조건 또는 소스들 사이에서 상당한 발현의 차이를 보이는 유전자를 선별하는 것이 바람직할 수 있다. 또 다른 예에서는, 두 조건들간의 발현의 차이가 미약한 유전자를 선별하는 것이 바람직할 수도 있다. 적어도 약 1.5 배 이상 차이가 있는 것이 바람직하지만, 세 배, 다섯 배 또는 열 배의 차이가 몇몇 예에서 바람직할 수도 있다. 관찰된 차이들과 질병 관련성이 통계학적으로 유의적임을 보장하기 위하여 데이터들에 대해 통계학적 평가를 행한다. 유전자들과 단백질들의 확인이 다른 정보를 얻기 위해 수행될 수 있다.
간암 마커를 위한 진단학적 사용
여기서 설명한 바와 같이, 표 1에서 제공되는 유전자들과 유전자 발현 정보는 간 조직의 질환 상태의 예측과 확인을 위한 진단용 마커로서 이용될 수도 있다. 예를 들어, 환자의 간 조직 샘플과 다른 샘플은 당업자에게 잘 알려진 방법으로 측정될 수 있으며 표 1의 하나 또는 그 이상의 유전자 발현 레벨은 비암화 간 조직과 암화 조직 또는 두 개 모두와 비교할 수도 있다. 비암화 또는 암화 간 조직의 발현 프로파일과 실질적으로 닮은 조직 또는 기타 샘플의 유전자 발현 프로파일이 질환의 진단을 돕는데 사용될 수도 있다. 비교 가능한 서열 또는 다른 정보들뿐만 아니라 발현 데이터들의 비교가 연구자와 진단자에 의해 수행될 수도 있으며, 여기서 설명하고 있는 컴퓨터와 데이터베이스의 도움으로 행해질 수도 있다.
질환 진행을 모니터링하기 위한 간 종양 마커의 사용
간암에 대한 분자적 발현 마커들은 형태학적 기준에 근거한 질환의 진행과 타입을 확인하기 위하여 사용할 수 있다. 예를 들어, 비암화 간 조직은 조직 샘플에서 발현되는 유전자와 세포의 타입에 근거하여 종양 조직과 구분 될 수 있다. 몇몇 상황에서는, 세포 타입과 유래의 확인이 전통적인 표준에 근거할 때 모호하다. 이러한 상황에서, 본 발명의 분자 발현 마커는 샘플이 유래한 곳이 간의 어느 부분인지, 유전자 발현이 변경되었는지 또는 정상이 아닌지를 확인하는데 유용하다 (대사 이상의 징조).
또한, 간의 새로운 부분 또는 다른 조직으로의 암 발생의 진행은 본 발명의 분자적 발현 마커를 사용한 관련 유전자들의 발현 양식을 다름으로써 모니터링될 수 있다. 특정 약제의 효능을 모니터링하는 것도 분자적 발현 마커의 발현 양식을 따름으로서 달성될 수 있다.
상기에서 설명한 바와 같이, 표 1에서 제공된 유전자들과 유전자 발현 정보는 질환의 진행, 예를 들어, 간암의 발생의 직접적인 모니터링을 위한 마커로서 사용될 수도 있다. 환자의 간 조직 샘플 내지 다른 샘플은 당업자에게 잘 알려진 방법으로 확인될 수 있고, 샘플에서 표 1의 유전자들의 발현 레벨은 비암화 간 조직, 간암으로부터의 조직 또는 이들 모두에서 확인된 발현 레벨에 비교될 수 있다. 이용 가능한 서열이나 다른 정보뿐만 아닌 발현 데이터의 비교가 연구원 및 진단자들에 의해 행해질 수도 있으며 여기서 설명하는 컴퓨터와 데이터베이스의 도움으로 수행될 수도 있다.
약제의 스크리닝을 위한 간암 마커의 사용
본 발명에 따르면, 잠재 약제의 사용이 여기서 확인하고자 하는 하나 또는 그 이상의 유전자 발현을 조절할 수 있는지 결정하기 위하여 스크리닝될 수 있다. 이는, 예를 들어, 특정 약제가 특정 간암 환자의 치료에 효과적인지를 결정하는데 도움이 될 수도 있다. 이러한 잠재적인 약제에 의하여 유전자의 발현의 레벨이 정상으로 회복되는 영향을 받을 경우에, 이 약제는 간암을 치료할 수 있다고 나타낼 수 있다. 유사하게, 건강한 정상 간 조직에서 발현되지 않는 유전자의 발현을 유발하는 약제는 간암의 치료에 있어서 반대 지표제(contra-indicated)가 될 수 있다.
본 발명에 따르면, 표 1에서 확인된 유전자들은 특이적으로 악성 형질전환을 가지는 세포, 예를 들어 간암 세포 내지 조직 샘플에 대한 후보 약제 또는 작용제의 효과를 평가하기 위한 마커로서 이용될 수도 있다. 후보 약제 또는 작용제는 주어진 마커 내지 표적 약제의 전사 내지 발현의 가능성을 알아보기 위하여 사용되며 마커와 표적 약제의 전사와 발현을 역조절(down-regulation)하거나 저해시킬 수 있다. 본 발명에 따르면, 약제에 영향을 받은 마커의 수를 관찰함으로써, 그리고 이를 다른 약제에 의해 영향받은 마커의 수와 비교함으로써, 약제 효능의 특이성를 비교할 수 있다. 더욱 특이적인 약제는 더욱 적은 수의 전사 표적에 영향을 미칠 것이다. 두 약제를 확인하기 위한 유사한 마커들은 효능에 있어서도 유사함을 나타낸다.
표 1에 정의되어 있는 마커 또는 마커들의 발현을 알아보기 위한 분석은 본 발명의 핵산의 발현 레벨의 변화를 관찰할 수 있는 사용가능한 수단을 사용할 수도 있다. 여기에서의 작용제(agent)은, 세포내 핵산의 업- 또는 다운-조절(up- or down-regulation) 발현이 가능하다면, 본 발명인 핵산의 발현을 조절한다고 말한다.
상기의 방법으로 분석된 작용제들은 무작위 또는 적합하게 선별되거나 제작될 수 있다. 여기에서의 작용제은, 본 발명의 단백질 단독 또는 이와 관련된 기질 및 결합 상대와 연관있는 특정 서열을 고려하지 않았을 때, 무작위로 선별된다고말한다. 이렇게 무작위로 선별된 작용제들의 예는, 화학물질 라이브러리, 펩티드와 결합된 라이브러리 및 유기체의 성장 배지의 사용이다.
여기에서의 작용제은, 그것이 표적 위치의 서열 및/또는 작용제의 기작과 관련하여 그것의 확인을 고려하는 비무작이적(nonrandom) 기반에서 선택될 때, 작용제가 타당하게 선별되거나 설계되는 것으로 말한다. 작용제는 작용 위치를 차지하는 펩티드 서열을 사용함으로써 타당하게 선별되거나 설계될 수 있다. 예를 들어, 타당하게 선별된 펩티드 작용제의 아미노산 서열은 기능적으로 동일한 임의의 위치의 아미노산 또는 유도체의 서열일 수 있다.
본 발명의 작용제들은, 예를 들어, 펩티드, 작은 화학 분자들, 비타민 유도체들, 탄수화물, 지질, 올리고뉴클레오티드 및 그것들의 공유, 비공유 결합의 복합체일 수 있다. 음극 전하를 띄는 단백질, 이러한 단백질을 암호화하는 DNA, 이러한 단백질들의 항체, 이러한 단백질들의 펩티드 단편들, 이러한 단백질들의 유사체들도 기능에 영향을 주기 위하여 세포 내로 삽입될 수도 있다. 여기서 사용된 "모방체(mimics)"는 모(parent) 펩티드와 화학적으로 다른 구조이지만 형태학적으로 또는 기능적으로 모 펩티드와 유사한 구조를 제공하기 위해 펩티드의 일부분 또는 여러 부분을 변형한 것을 의미한다(Molecular Biology and Biotechnology, Meyers(ed.)에서 VCH publishers, 1995 참조). 당업자라면 본 발명의 작용제의 구조적인 특징에 있어 제한이 없음을 쉽게 인식할 수 있을 것이다.
치료제로서의 간암 마커의 사용
표 1의 핵산 분자 발현 또는 표 1의 핵산 분자에 의해 암호화되는 적어도 하나의 활성의 업- 또는 다운- 조절 또는 조정을 하는, 작용물질 및 길항물질과 같은, 작용제는 이러한 핵산 분자들에 의해 암호화되는 단백질의 활성과 기능과 관련된 생물학적 및 병리학적 과정을 조절하기 위해 사용될 수도 있다. 이러한 작용제들은 표 1의 염기 분자 그 자체, 암호화된 단백질, 또는 이러한 염기 분자의 오픈 리딩 프레임(open reading frame)의 일부 또는 전부와 같은 분자들 일 수 있다.
표 1의 핵산 서열로부터 유래한 안티-센스 올리고뉴클레오티드 분자는 간암에서 상승된 수준으로 발현된, 표 1의 하나 또는 그 이상의 유전자의 발현을 다운-조절(down-regulation)하는데 사용될 수도 있으며, 예를 들어, 안티-센스 유전자 치료법이 있다. 이는 표 1의 하나 또는 그 이상의 유전자들 발현을 다운-조절하는 유효량의 안티-센스 뉴클레오티드를 첨가함으로써 이뤄진다. 이러한 안티-센스 분자들은 유전자 서열에서 다양한 종류의 돌연변이, 소실, 삽입 또는 공정된 변이체(spliced variant)의 DNA서열로부터 형성될 수 있다. 이러한 작용제들은, 표 1의 유전자에 의해 암호화되는 하나 또는 그 이상의 단백질의 미발현 또는 현저히 감소된 발현과 관련이 있는 간암들에서 유전자 발현을 유발하는데 사용할 수도 있다.
여기에서의 객체는, 포유류가 본 발명의 유전자에 의해 생물학적, 병리학적 과정의 조절을 필요로 한다면 어떠한 포유류라도 대상이 될 수 있다. 용어 "포유류(mammal)"이란 Mammalia 종에 속하는 개체로서 정의된다. 본 발명은 특히 인간 개체의 치료에 유용하다.
병리학적 과정이란 해로운 효과를 유발하는 생물학적인 과정들의 카테고리를 의미한다. 예를 들어, 본 발명의 유전자 발현은 간 기관에서 세포 과형성(hyperplasia)과 관련이 있으며, 특히 악성적인 세포 과형성과 관련이 있다. 여기에서의 작용제는, 그것이 진행의 강도와 심각성을 감소시킬 수 있을 때, 병리학적 과정을 조절한다고 말한다. 예를 들어, 유전자 발현을 어떠한 방법으로 업- 또는 다운-조절하거나 본 발명의 적어도 하나의 활성을 가지는 유전자의 발현을 조절하는 작용제를 투여함으로써, 간암은 예방되거나 또는 질환의 진행을 조절할 수도 있다.
본 발명의 작용제들은 단독으로 제공될 수 있거나, 또는 특정 병리학적 과정을 조절할 수 있는 다른 작용제들과 함께 제공될 수 있다. 예를 들어, 본 발명의 작용제들은 다른 알려진 약제와 함께 투여될 수도 있다. 여기에서의 두 개의 작용제들은, 이들이 동시에 투여되거나 각각의 작용제가 동시에 작용될 수 있는 형태로 독립적으로 투여될 경우, 함께 투여되는 것으로 말한다.
본 발명의 작용제들의 투여의 형태는 비경구적, 피하, 정맥, 근육, 복강, 경피 및 경구투여(buccal route)가 될 수 있다. 다른 방법으로 또는 동시에, 구강을 통한 투여(oral route)도 될 수 있다. 투여의 양은 나이, 건강상태, 체중, 동시 치료의 종류 및 가능하다면, 치료의 빈도, 대상 효과의 본질에 좌우된다.
본 발명은 또한 본 발명의 단백질의 발현을 조절하거나 적어도 하나의 활성을 조절하는 하나 또는 그 이상의 작용제을 포함하는 조성물을 제공한다. 경우마다 필요로 하는 양이 달라지는 반면에, 각 성분의 최적의 유효량의 결정은 당업계의 기술에 속한다. 일반적인 용량은 0.1 내지 100 ㎍/㎏ body wt를 포함하는 것으로 구성되어 있다. 바람직한 용량은 0.1 내지 10 ㎍/㎏ body wt를 포함하는 것으로 구성되어 있다. 바람직한 용량은 0.1 내지 1 ㎍/㎏ body wt를 포함하는 것으로 구성되어 있다.
약제학적 활성 작용제 이외에, 본 발명의 조성물은, 활성 위치까지의 전달에 약제학적으로 사용될 수 있는 약제로 활성 화합물의 제조하는 것을 용이하게 만드는 부형제(exipient) 또는 보조제(auxiliary)를 포함하는 것으로 구성된 약제학적으로 허용될 수 있는 적절한 담체를 포함할 수도 있다. 활성성분의 비경구적인 투여에 적합한 제형으로는, 용해 가능한 형태인 활성 화합물, 예를 들어, 수용성 염의 수용성 용액을 포함한다. 또한, 적당한 오일성 주사 현탁액으로의 활성 화합물의 현탁액이 투여될 수도 있다. 적절한 친유성 용매 또는 비히클은 참기름(sesame oil) 등의 지방 오일, 또는 에틸 올레이트 등의 합성 지방산 에스테르, 또는 트리글리세리드를 포함한다. 액상 주사 현탁액은, 현탁액의 점도를 증가시키는, 예를 들어, 소듐 카르복시메틸 셀룰로오즈, 솔비톨 및/또는 덱스트란을 포함하는 기재들을 포함할 수도 있다. 선택적으로, 현탁액은 또한 안정제를 포함할 수도 있다. 세포내로의 이동을 위해 작용제를 캡슐화하기 위하여 리포좀(Liposome)이 사용될 수가 있다.
전신 투여를 위한 본 발명에 따른 약제학적 제형은 장관, 경구 또는 국소 투여용으로 제형화될 수도 있다. 세 종류의 형태 모두가 활성 성분의 전신 투여를 이루기 위해 동시에 사용될 수도 있다.
경구 투여에 적합한 제형은, 단단하거나 부드러운 젤라틴 캡슐, 알약, 정, 코팅된 정, 엘릭시르제(elixir), 현탁제, 시럽 내지 흡입제 그리고 조절된 방출형(controlled release form)을 포함한다.
본 발명의 방법을 실행할 때, 본 발명의 화합물들은 단독으로 사용하거나, 함께 사용하거나, 또는 다른 치료제 및 진단제와 함께 사용될 수도 있다. 임의의 바람직한 실시예에서, 본 발명의 화합물들은, 의약계에서 일반적으로 허용되는 약제 제조법에 따라 제조된 물질과 함께 동시 투여될 수도 있다. 본 발명의 화합물들은 생체 내(in vivo)에서, 보통은 인간, 설치류, 개, 고양이, 양, 말, 소, 돼지와 같은 포유류에서, 또는 생체 외(in vitro)에서 사용될 수 있다.
분석 형태들
간암에서 달리 발현되는 것으로 확인된 유전자들은 주어진 샘플에서의 유전자 또는 다중 유전자들의 발현 레벨을 정량하거나 탐지하기 위한 다양한 핵산 탐지 분석 방법에 사용될 수도 있다. 예를 들어, 전통적인 노던 블롯팅(nothern blotting), 뉴클레아제 보호(nuclease protection), RT-PCR 그리고 또 다른 표시 방법 등이 유전자 발현 레벨을 확인하는데 사용될 수도 있다. 5 내지 50 개와 같은 적은 양의 유전자를 검사하는 방법에서는 고 산출 PCR(high-throughput PCR)이 사용될 수도 있다.
또한, 여기서 확인된 유전자들의 단백질 생성물은 발현량을 결정하기 위하여 분석될 수도 있다. 단백질을 분석하는 방법으로는 웨스턴 블롯, 면역 침전법 및방사면역학분석(radioimmunoassay) 등이 포함된다. 몇몇 방법들에서는, 발현의 확인자로서 mRNA를 분석하는 것이 바람직할 수 있다. mRNA를 분석하는 수 있는 방법으로는 노던 블롯(nothern blot), 슬롯 블롯(slot blot), 돗 블럿(dot blot) 그리고 올리고뉴클레오티드 어레이를 통한 혼성화 방법이 포함된다. 또한 특정 단백질, mRNA, DNA를 측정하는 특수하고 정량적인 방법이 사용될 수도 있다. 그러나 본 발명의 방법과 측정은, 많은 양의 유전자를 검출하기 위한 어레이 또는 칩 혼성화 기반(hybridization-based) 방법을 가지고 가장 효과적으로 설계된다.
용액 또는 고체 지지체 기반 형태의 분석을 포함한 어떠한 혼성화 분석 형태라도 사용될 수 있다. 바람직한 고체 지지체는 DNA 칩 또는 유전자 칩으로도 알려져 있는 고집적 어레이(high-density array)를 이용하는 것이다. DNA 칩의 하나의 변형은 그것을 완전히 통과하는 수 백 내지 수 천의 분별적인 미세한 채널(microscopic channel)들을 포함하는 있다. 상기의 채널 내부 표면에 프로브가 심어져 있고, 검사하고자 하는 표적 분자들이 채널 위를 지나면서, 혼성화를 위해 프로브와 매우 근접하게 된다. 또 다른 분석 형태에서, 표 1의 적어도 2 개의 유전자들에 대한 프로브를 포함하고 있는 유전자 칩이, 여기서 설명하는 것과 같은 치료된 또는 노출된 세포에서 유전자 발현에서의 변화를 직접적으로 모니터링하거나 검출하는데 사용될 수도 있다.
본 발명의 유전자들은 어떠한 용이한 샘플 형태로든지 분석될 수도 있다. 예를 들어, 샘플들은 mRNA 내지 역전사된 mRNA의 형태로 분석될 수도 있다. 샘플들은 복제될 수도 있고 그렇지 않을 수도 있고, 샘플들 또는 개개의 유전자들은 증폭될 수도 있고 그렇지 않을 수도 있다. 복제 그 자체는 군집내에서 유전자들의 대표성을 편향되게 하는 것 같지는 않다. 그러나, 소스로서 polyA+RNA를 사용하는 것이 바람직할 수 있는데, 이는 프로세싱(processing) 과정이 완전히 이뤄지지 않은 상태로 사용될 수 있기 때문이다. 일부 실시예에서, 유전자에 의해 발현된 단백질 또는 펩티드를 분석하는 것이 바람직할 수도 있다.
표 1의 발현 마커 유전자들의 서열은 공중의 데이터베이스로부터 얻을 수 있다. 상기 표 1에는 기탁번호(accession number), 서열번호ID 및 각 서열에 대한 이름이 명시되어 있다. GenBank의 유전자 서열들은 그 전체로서 여기에 참조로서 명세서적으로 합체된다(www.ncbi.nim.nih.gov).
부가적인 분석 형태들이 표 1에서 확인된 유전자들의 발현을 조절하될 작용제의 가능성을 모니터링하기 위하여 사용될 수 있다. 예를 들어, 상기에서 설명한 바와 같이, mRNA 발현은 본 발명의 핵산에 프로브를 혼성화시킴으로써 직접적으로 모니터링될 수도 있다. 적당한 조건과 시간에서 세포주를 검사하기 위한 작용제에 노출시키고 전체 RNA와 mRNA를 Sambrook et al., Molecular Cloning - A Laboratory Manual, Third ed., Cold Spring Harber Laboratory Press, Cold Spring Harbor, New York, 2001에 기재되어 있는 표준 방법과 순서에 따라 분리한다. 다른 실시예에서, 상기에서 분리된 하나 또는 그 이상의 RNA를 유전자 칩에 가하기 전에 증폭시키는 것이 바람직할 수도 있다. 당업계에 잘 알려진 기술을 이용하여 RNA를 역전사 내지 DNA 형태로 증폭시킬 수도 있으며, 또는 DNA 형태로 역전사될 수도 있고, 재조합 RNA를 형성하기 위한 전사를 위한 주형으로 DNA가 사용될 수도 있다. 유전자 칩에 효과적으로 혼성화시키기 위한 충분한 양의 핵산의 생성이 가능한 어떠한 방법이라도 사용될 수 있다.
또 다른 형태로는, 오픈 리딩 프레임(open reading frame) 및/또는 표 1의 유전자의 3' 또는 5' 조절 부위 사이에 리포터 유전자 융합체(reporter gene fusions)와, 분석가능한 임의의 융합 파트너(fusion partner)를 포함하고 있는 세포주를 제조할 수도 있다. 파이어플라이 루시퍼라아제(firefly luciferase) 유전자와 클로람페니콜 아세틸트랜스퍼라아제(chloranphenicol acetyltransferase)를 암호화하는 유전자(Alam et al.,Anal Biochem 188;245-254, 1990)를 포함한, 많은 수의 분석가능한 융합 파트너들이 공지되어 있다. 그런 다음, 리포터 유전자 융합체를 포함하고 있는 세포주는 적당한 조건과 시간하에서 검사하고자 하는 작용제에 노출된다. 작용제에 노출된 샘플과 대조군 샘플간의 리포터 유전자의 차등 발현은 핵산의 발현을 조절하는 작용제를 확인시킨다.
또 다른 분석 형태로서, 본 발명의 하나 또는 그 이상의 유전자 생성물을 생리학적으로 발현하는 세포나 세포주가 우선 확인된다. 그렇게 확인된 세포나 세포주들은, 바람직하게는, 그의 전사 및 해독 형태가 외인성 작용제에 대한 정상 또는 간암 조직의 반응을 충실히 모방하는 것을 확인하는데 필요한 세포성 기구들(cellular machinery)을 포함하는 것으로 구성되어 있다. 이러한 기구들은 적합한 표면 형질도입 기작 및/또는 세포질 요소들을 포함한다. 이러한 세포주들은, 요구되는 것은 아니지만, 간 조직에서 유래된다. 그런 다음, 이러한 세포와 세포주들을 작용제에 접촉시킬 수도 있고, 그런 다음 관심있는 하나 또는 그 이상의 유전자의 발현을 분석할 수도 있다. 유전자들은 mRNA 레벨과 단백질 레벨로서 분석될 수도 있다.
또다른 실시예에서, 이러한 세포와 세포주는, 하나 또는 그 이상의 항원 단편을 암호화하는 하나 또는 그 이상의 핵산 서열과 융합하는 표 1에서 확인된 대상 유전자의 끝부분을 포함하는 작동가능한 5'-프로모터으로 구성되어 있는 발현체를 포함하고 있는 발현 운반체(예를 들어, 플라스미드 또는 바이러스 벡터)로 형질 도입되거나 형질 전환될 수도 있다. 이러한 발현체는, 항원 단편을 암호화하는 서열의 5' 내지 3'에 위치할 수도 있는 대상 유전자의 암호화 서열 전체 또는 일부분를 포함하는 구성되어 있을 수도 있다. 대상 유전자의 암호화 서열은 유전자 융합의 전사 후에 해독이 될 수도 있고 안 될 수도 있다. 적어도 하나의 항원 단편이 해독될 수도 있다. 항원 단편들은, 이들이 대상 유전자의 프로모터의 전사 제어를 받게되고 대상 유전자의 발현 형태와 실질적으로 유사한 방법으로 발현되도록, 선택된다. 항원 단편들은 천연 폴리펩티드와는 차이가 있는 분자량을 갖는 폴리펩티드로서 발현될 수도 있다.
일부 실시예에서, 본 발명의 유전자 생성물들은 면역학적으로 구별되는 태그(tag)를 더 포함하는 것으로 구성될 수도 있다. 이러한 과정은 당업자들에게는 잘 알려져 있다.(Sambrooket al.,supra). 그런 다음, 상기의 형질 도입 및 전환된 세포와 세포주는 적당한 조건 하에서 작용제와 접촉한다; 예를 들어, 이러한 작용제는 약제학적으로 허용되는 보형제를 더 포함하는 것으로 구성되어 있고, 생리학적 산도(pH) 조건에서의 인산 완충용액 생리식염수(phosphate buffer saline:PBS), 생리학적 산도(pH) 조건에서의 Eagles balanced salt 용액(BSS), 혈정을 포함하는 것으로 구성되어 있는 PBS 또는 BBS, 또는 37℃에서 배양된 PBS 또는 BBS와 혈청을 포함하는 것으로 구성된 조절된 배지와 같은 생리학적 버퍼 수용액에서 구성되어 있는 세포와 접촉하게 된다. 이러한 조건들은 당업자에 의해 필요하게 생각되는 정도로 용이하게 조절될 수 있다. 세포를 작용제와 접촉시킨 다음, 상기의 세포는 분쇄되고, 세포 파쇄물의 폴리펩티드는, 폴리펩타이드 분획을 모우고 역학적 방법(예를 들어, ELISA, 면역침강법 및 웨스턴 블롯)에 의해 더 처리되게 항체와 접촉시키도록 하기 위해 분획된다. 작용제-접촉 샘플("agent-contacted sample")으로부터 분리한 단백질들은 세포가 단지 부형제와 접촉된 대조군 샘플과 비교하고, 대조군에 비교된 "작용제-접촉 샘플"으로부터 면역학적으로 발생한 신호의 증가 또는 감소가 작용제의 효능을 식별하는데 사용될 것이다.
본 발명의 또다른 실시예에서는 표 1의 유전자들에 의해 암호화된 단백질의 발현 레벨, 농도, 적어도 하나의 활성을 조절하는 작용제를 확인하기 위한 방법들을 제공한다. 이러한 방법 및 분석들은 소망하는 활성을 모니터링하거나 검출하는 수단을 사용할 수도 있다.
한 예에서, 검사하고자 하는 작용제에 노출된 세포 군집에서 생성된 본 발명의 단백질의 상대적인 양이 대조군으로서 노출되지 않은 세포 군집에서 생성된 단백질의 양과 비교될 수도 있다. 이러한 예에서, 특이 항체와 같은 프로브들은 다른 세포 군집에서의 단백질의 차등 발현을 모니터링하는데 사용된다. 세포주와 세포 군집들은 적합한 조건과 시간 하에서 검사하고자 하는 시약에 노출된다. 노출된 세포주나 세포 군집과, 비처리 세포주 및 세포 군집 대조군으로부터 세포성 파쇄물이 준비될 수도 있다. 그런 다음, 이러한 세포성 파쇄물들은 특이 항체와 같은 프로브를 가지고 분석된다.
프로브 제작
여기서 설명하고 있는 유전자 서열에 근거한 프로브들은 일반적인 사용되는 방법으로 준비될 수도 있다. 세포 내지 조직표본을 분석하기 위한 올리고뉴클레오티드 프로브들은 바람직하게는 적절한, 상보적인 유전자 또는 전사체에 특이적으로 혼성화되기에 충분한 길이로 되어 있다. 일반적으로 이러한 올리고뉴클레오티드 프로브들은 적어도 10, 12, 14, 16, 18, 20 또는 25 개의 염기 길이를 가질 것이다. 어떤 경우에 있어서는, 적어도 30, 40 또는 50 개의 염기 길이를 가진 프로브가 바람직하다.
당업자들은 수많은 어레이 설계가 본 발명을 실행하는데 있어 적합하는 것을 이해할 것이다. 일반적으로 고집적 어레이는 대상 서열에 특이적으로 혼성화를 이루는 많은 프로브들을 포함하고 있다. 주어진 유전자 또는 유전자들에 대한 프로브를 제작하기 위한 방법이 예를 들어 WO99/32660에 기재되어 있다. 또한, 하나의 바람직한 실시예에서, 어레이는 하나 또는 그 이상의 대조 프로브들을 포함할 것이다.
본 발명의 고집적 어레이 칩(high-density array chip)은 "시험 프로브(test probe)"들을 포함하고 있다. 시험 프로브는 길이에 있어서 약 5 개 내지 500 개또는 약 5 개 내지 50 개의 뉴클레오티드, 더욱 바람직하게는 약 10 개 내지 40 개의 뉴클레오티드, 더욱 바람직하게는, 약 15 개 내지 40 개의 뉴클레오티드의 범위에 있는 올리고뉴클레이티드일 수 있다. 특히 바람직한 실시예에서, 이러한 프로브들은 길이에 있어서 약 20 개 내지 25 개이다. 또다른 바람직한 실시예에서, 시험 프로브는 단일 또는 이중 DNA 서열들이다. DNA 서열들은 원 소스로부터 분리되거나 복제될 수도 있으며 또는 주형으로서 천연 핵산을 사용하여 천연 소스로부터 증폭될 수도 있다. 이러한 프로브들은 발현을 이들이 검출하도록 설계되어 있는 유전자의 특정 단위서열에 상보적인 서열을 가지고 있다. 따라서, 시험 프로브는 이것이 검출하고자 하는 표적 핵산에 특이적으로 혼성화될 수 있다.
대상 표적 핵산에 결합하는 시험 프로브 이외에, 고밀도 어레이는 수많은 대조 프로브들을 포함할 수 있다. 이러한 대조 프로브는 (1) 표준화 대조군(normalization control); (2) 발현 레벨 대조군(expression level control); 및 (3) 불일치 대조군(mismatch control)으로 칭해지는 3 개의 카테고리로 나뉘어진다.
"표준화 대조군(Normalization control)"은 핵산 샘플에 부가되는 표지된 레퍼런스 올리고뉴클레오티드(labeled reference oligonucleotide) 또는 핵산 서열에 상보적인 핵산 프로브 또는 올리고뉴클레오티드 프로브이다. 혼성화 후 표준화 대조군에서 얻어진 신호는, 혼성화 조건, 표지 강도, "reading" 효율, 및 완벽한 혼성화의 신호가 다양한 어레이들 사이에서 변화도록 야기시킬 수 있는 기타 요소들에서의 변화에 대한 제어를 제공한다. 바람직한 실시예에서, 어레이 상의 모든 다른 프로브들로 읽히는 신호(예를 들어, 형광의 강도)는 대조 프로브로부터의 신호(즉, 형광의 강도)에 의해 나누어짐으로써, 이로써 측정값을 표준화한다.
실질적으로 임의의 프로브가 표준화 대조군(normalization control)로서 작용할 수도 있다. 그러나, 혼성화의 효율은 프로브의 길이와 염기의 구성성분에 따라 변하는 것으로 인식된다. 바람직한 표준화 프로브는 배열 상에 존재하는 다른 프로브들의 평균길이를 반영하도록 선별되지만 이러한 길이의 범주를 커버하기 위해 선택될 수도 있다. 표준화 대조군은 어레이 상에 존재하는 다른 프로브의 (표준)염기 조성을 반영하기 위해 또한 선택될 수도 있지만, 실시예에서, 하나 내지 소수의 프로브만이 사용되고 있으며, 이들은 잘 혼성화(즉, 이차 구조는 존재하지 않음)되고 어떠한 표적-특이 프로브와는 일치하지 않도록 선택된다.
발현 레벨 대조군(Expression level control)은 생물학적 샘플에서 연속적으로 발현되는 유전자에 특이적으로 혼성화되는 프로브이다. 실질적으로 어떠한 구조적으로 발현된 유전자는 발현 레벨 대조군에 적합한 표적임을 제공한다. 일반적인 발현 레벨 대조군 프로브는, 다음의 것으로 한정되는 것은 아니지만, β-액틴(actin) 유전자, 트랜스페린(tranferrin) 수용체 유전자, GAPDH 유전자와 같은, 구조적으로 발현된 "하우스킵핑 유전자(housekeeping gene)"의 하부서열에 상보적인 서열을 가지고 있다.
비결합(또는 불일치) 대조군(Mismatch control)이 표적 유전자에 대한 유전자들, 표준화 대조군, 또는 발현 레벨 대조군을 위한 제공될 수도 있다. 비결합 대조군은, 하나 또는 그 이상의 불일치된 염기이 존재한다는 점을 제외하고는, 이들의 대응 시험 또는 대조군 프로브들과 동일한 올리고뉴클레오티드 프로브 또는 핵산 프로브들이다. 불일치된 염기는, 그렇지 않다면 프로브가 특이적으로 혼성화되게 되는 표적 서열에서 대응 염기에 상보적이지 않도록 선별된 염기이다. 하나 또는 그 이상의 비결합은, 적합한 혼성화 조건(예를 들어, 스트린전트 조건)에서, 시험 또는 대조군 프로브가 표적 서열과 혼성화를 이룰 것으로 예상되지만 불일치 프로브는 혼성화되지 않도록(또는 유의적으로 덜 혼성화되도록) 선택된다. 바람직한 불일치 프로브들은 중앙 불일치(central mismatch)를 포함한다. 그러므로 예를 들어, 프로브가 20 개의 염기로 구성된 경우에, 대응하는 불일치 프로브 는 6 에서 14 사이의 임의의 위치(중앙 불일치)에서 단일 염기 불일치(예를 들어, A이 G, C 또는 T으로 치환됨)를 제외하고는 동일한 서열을 가질 수도 있다.
그러므로 불일치 프로브는 프로브가 대상으로 하는 표적이외의 샘플에서의 핵산에 대한 교차 혼성화 또는 비특이적인 결합을 위한 대조군을 제공한다. 불일치 프로브는 또한 혼성화가 특이적인지 또는 아닌지를 나타낸다. 예를 들어, 만약 표적 서열이 존재한다면, 완벽한 일치 프로브들은 불일치 프로브보다 계속적으로 더 밝아야한다. 또한, 만약 모든 중앙 불일치(central mismatch)이 존재한다면, 불일치 프로브는 변이를 탐지하기 위해 사용될 수 있다. 완벽한 일치와 불일치 프로브(I(PM)-I(MM)) 사이에 강도의 차이는 혼성화된 물질의 농도를 측정할 수 있는 좋은 수단을 제공한다.
핵산 샘플
당업자에게는 명료한 것처럼, 본 발명의 방법 및 분석에서 사용된 핵산 샘플은 사용가능한 방법과 과정에 의해 준비될 수도 있다. 전체 mRNA를 분리하는 방법은 당업자에게 잘 알려진 기술이다. 예를 들어, 핵산을 분리하고 정제하는 방법은Chapter 3 of Laboratory Techniques in Biochemistry and Molecular Biology, Vol.24,Hybridization With Nucleic Acid Probes: Theory and Nucleic Acid Probes, P. Tijssen(ed.) Elsevier Press, New York, 1993에 자세하게 기재되어 있다. 이러한 샘플은 RNA 샘플뿐만 아니라, 대상 세포 또는 조직으로부터 분리한 mRNA에서 합성한 cDNA도 포함한다. 또한, 이러한 샘플은 cDNA로부터 증폭한 DNA와 증폭된 DNA로부터 전사한 RNA도 포함한다. 당업자들은, 호모제네이트(homogenate)가 사용되기 전에 호모제네이트에 존재하는 RNase를 억제하거나 파괴하는 것이 더 바람직할 수도 있다는 것을 인식할 것이다.
생물학적 샘플은, 세포주와 조직배양세포와 같은 생체 외(in vitro)에서 발생된 세포뿐만 아니라 임의의 유기체로부터의 임의의 생물학적 조직, 세포, 체액으로 되어 있을 수도 있다. 이러한 샘플들은 종종 환자로부터 유래한 "임상 샘플"일 것이다. 통상적인 임상 샘플은, 다음의 것으로 한정되는 것은 아니지만, 간 조직, 객담, 혈액, 혈액 세포(예를 들어, 백혈구), 조직 또는 미세바늘 생검 샘플(fine needle biopsy sample), 소변, 복강내 장액성 액체, 흉막 액체, 또는 그것의 세포 조직 등을 포함한다. 생물학적 샘플은 생물 조직학적 목적으로 취한 냉동 부위 또는 포르말린 고정 부위와 같은 조직의 부위를 또한 포함할 수 있다.
고체 지지체
차등 발현되는 유전자들에 대한 올리고뉴클레오티드 프로브들을 포함하는 고체 지지체는 당업자에게 잘 알려져 있는 고체 또는 반고체 지지 물질일 수 있다. 적합한 예로는, 다음의 것으로 한정되는 것은 아니지만, 막, 필터, 조직 배양 용기, 폴리비닐클로라이드 용기, 비드, 시험 스트립, 실리콘 또는 유리계 칩과 같은 물질이 포함된다. 적합한 유리 용기와 혼성화 방법은 널리 이용되고 있으며, 그 예로서, Beattie(WO 95/11755)에 기재되어 있다. 올리고뉴클레오티드가, 직접적이나 간접적으로, 또는 공유적으로 또는 비공유적으로 부착되는 임의의 고체 표면이 사용될 수 있다. 하나의 실시예에서, 동일한 고체 지지체에 일부 올리고뉴클레오티드를 공유적으로, 그리고 나머지를 비공유적으로 부착하는 것이 바람직할 수 있다.
바람직한 고체 고정체는 고집적 어레이 또는 DNA 칩이다. 이들은 어레이의 기설정 위치에 있는 특정한 올리고뉴클레오티드 프로브를 포함한다. 각각의 기설정 위치는 프로브의 하나 이상의 분자를 포함할 수도 있지만, 기설정 위치상의 각 분자는 동일한 서열을 가지고 있다. 이러한 기설정 위치를 "특징(feature)"라 칭한다. 예를 들어, 하나의 고체 지지체 위에는 약 2, 10, 100, 1000, 10,000, 100,000 또는 400,000 개의 특징들이 존재할 수도 있다. 이러한 고체 지지체, 또는 프로브가 부착되는 면적으로 제곱 센티미터 단위일 수 있다.
유전자 발현을 관찰하기 위한 올리고뉴클레오티드 프로브 어레이는 당업계에 알려져 있는 임의의 기술들에 따라 만들어지고 사용될 수 있다(예를 들어,Lockhart et al.,Nat Biotechnol 14:1675-1680,1996;McGall et al.,Proc Natb Acad Sci USA 93:13555-13460, 1996 참조). 이러한 프로브 어레이는 적어도 2 개 또는 그 이상의 여기서 설명하고 있는 2개 또는 그 이상의 유전자와 상보적으로 혼성화를 이루는 올리고뉴클레오티드를 포함할 수도 있다. 또한 이러한 어레이는 적어도 여기에 기재된 3, 4, 5, 6, 7, 8, 9, 10, 20, 30, 50, 70 또는 그 이상의 유전자와 상보적으로 혼성화를 이룬는 올리고뉴클레오티드를 포함할 수도 있다.
최소한의 합성 단계들을 가지고 올리고뉴클레오티드의 고집적 어레이를 형성하는 방법은 잘 알려져 있다. 올리고뉴클레오티드 유사체 어레이는, 다음의 것으로 한정되는 것은 아니지만, light-direct chemical coupling 및 mechanically directed coupling (Pirrung et al.,(1992) U.S. Patent No. 5,143,854; Fodor et al.,(1998) U.S. Patent No.5,800,992; Chee et al.,(1998) U.S. Patent No. 5,837,832 참조)을 포함하는 다양한 방법에 의해 고체 기질상에서 합성될 수 있다. 간략하게 말해서, 유리 표면 위에서의 올리고뉴클레오티드 어레이의 light-direct 조합적 합성은 automated phosphoramidite chemistry 와 chip masking 기술을 사용하여 수행된다. 하나의 특수한 실행예에서, 유리 표면은, 광 민감성 보호기에 의해 차단된 하이드록실기, 아미노기와 같은 관능기를 포함하는 실란제(silane reagent) 반응물로 처리된다. 포토리소그래픽 마스크(photolithogaphic mask)를 통한 광분해가, 들어오는 5'-광보호 뉴클레오시드 포스포라미다이트(photoprotected nucleoside phosphoramidites)와 반응할 준비가 되어있는 관능기를 선택적으로 노출되는데 사용된다. 이러한 포스포라미다이트는오직 조광되는(따라서 광민감 블로킹 그룹의 제거에 의해 노출되는) 부위와 반응한다. 따라서, 이들 부위에 오직 부가된 포스포라미다이트가 이전 단계로부터 선택적으로 노출된다. 이러한 단계들은, 소망하는 서열 어레이가 고체 표면에서 합성될 때까지 반복된다. 어레이 상의 상이한 위치에서 상이한 올리고뉴클레오티드 유사체의 조합적 합성은, 합성 중의 조광의 패턴과 커플링제(coupling agent)의 첨가에 의해 결정된다.
상기의 것 이외에, 단일 기질 상에서 올리고뉴클레오티드의 어레이를 형성하기 위해 이용되는 추가적인 방법들이 Fodor et al. WO 93/09668에 기재되어 있다. 또한, 고집적 기설정 위치에 기제작 또는 천연 핵산들을 침적함으로써 핵산 어레이(high-densuty nucleic acid array)가 제작될 수 있다. 합성 또는 천연 핵산들은 광-인도 표적화(light directed targeting)과 올리고뉴클레오티드-인도 표적화(oligonucleotide directed targeting)에 의해 기질의 특정한 장소에 침적된다. 또 다른 실시예에서는 핵산을 특정 위치에 침적하기 위해 장소를 이동하는데 디스펜서를 이용한다.
혼성화
핵산의 혼성화는 간단하게는, 상보적 염기 짝지움(paring)을 통해 프로브와 이것의 상보적인 표적이 안정한 혼성 이중부위(hybrid duplex)를 형성할 수 있는 조건에서 프로브와 표적 핵산이 접촉하는 것과 관련이 있다(Lockhartet al.,(1999) WO 99/32660 참조). 그런 다음, 혼성 이중부위를 형성하지 않는 핵산은 세척되고, 일반적으로 결합 탐지가능 표지를 통해 탐지될 수 있는 혼성화된 핵산만을 남긴다. 일반적으로, 핵산은 온도를 상승시킴에 따라 또는 핵산을 포함하는 완충용액의 염의 농도를 감소시킴에 따라 변경된다는 것으로 인식되고 있다. 낮은 스트린전시 조건(예를 들어, 저온과 높은 염)하에서, 결합된 서열이 완전히 상보적이지 않은 경우에도, 혼성 이중부위(즉, DNA-DNA, RNA-RNA 및 RNA-DNA)가 형성될 것이다. 따라서, 혼성화의 특이성은 더욱 낮은 스트린전시에서 감소된다. 역으로, 더욱 높은 스트린전시(예를 들어, 고온 및 낮은 염)에서는, 성공적인 혼성화는 더욱 적은 불일치를 요구한다. 당업자들은 혼성화 조건이 임의의 정도의 스트린전시를 제공하기 위해 선택될 수 있다는 것을 인식할 것이다. 바람직한 실시예에서, 37℃ 6xSSPE-T(0.005% Triton x-100)에서의 경우, 혼성화를 보장하기 위해 혼성화는 낮은 스트린전시에서 행해지고, 그런 다음, 불일치 혼성 이중부위를 제거하기 위해 더 높은 스트린전시에서 연속적인 세척을 행한다. 연속적인 세척은 소망하는 수준의 혼성화 특이성이 얻어질 때까지 점진적으로 더 높은 스트린전(예를 들어, 30℃와 50℃에서 0.25xSSPET-T)시에서 수행될 수도 있다. 스트린전시는 또한 포름아마이드와 같은 시약의 첨가에 의해 증가될 수 있다. 혼성화의 특이성은, 존재할 수 있는 다양한 대조군들에 대한 혼성화와, 시험 프로브들에 대한 혼성화의 비교에 의해 평가될 수도 있다(예를 들어, expression level control, normalization control, mismatch control, 등).
일반적으로, 혼성화 특이성(스트린전시)와 신호 강도 사이에는 트레이트오프(tradeoff)가 있다. 따라서, 하나의 바람직한 실시예에서, 일정한 결과를 생성하고 배경 강도(background intensity)의 대략 10% 보다 더 큰 신호 강도를 제공하는 가장 높은 스트린전시에서 세척이 행해진다. 따라서, 하나의 바람직한 실시예에서, 혼성화 어레이(hybridization array)는 연속적으로 더 높은 스트린전시 용액에서 세척되고 각각의 세척과정 사이에 확인된다. 그렇게 발생된 데이터의 분석은, 혼성화 패턴이 그 이상에서는 적절히 변경되지 않으며 대상인 특정 올리고뉴클레오티드에 대한 적합한 시호를 제공하는, 세척 스트린저시를 보여줄 것이다.
신호 탐지
혼성화된 핵산은 통상적으로, 샘플 핵산에 결합된 하나 또는 그 이상의 표지들을 탐지함으로써 직접 탐지된다. 표지는 당업자에게 잘 알려진 많은 수단들 중에서 임의의 수단(Lockhart et al.,(1999) WO 99/32660)에 의해 합체될 수도 있다.
데이터베이스
본 발명은, 다양한 간 조직 샘플들에서의 유전자 발현 정보뿐만 아니라, 예를 들어 표 1의 하나 또는 그 이상의 유전자들에 대한 서열 정보를 포함하고 있는 상관적인 데이터베이스를 포함한다. 또한, 이러한 데이터베이스는, 서열 정보와 관련있는 유전자에 대한 기술적(descriptive) 정보, 조직 샘플의 임상 상태에 관한 기술적 정보, 또는 샘플이 얻어진 환자에 관한 정보와 같은 주어진 서열 또는 조직 샘플과 관련한 정보를 또한 포함하고 있을 수도 있다. 이러한 데이터베이스는 또한, 예를 들어, 데이터베이스 및 유전자 발현 데이터베이스 등의 다른 부분들을 포함하도록 설계될 수도 있다. 본 발명의 데이터베이스는 컴퓨터가 인식할 수 있는 사용가능한 임의의 매체에 저장될 수도 있다. 이러한 데이터베이스의 구성과 구조를 위한 방법은 널리 알려져 있고, Akerblom et al.,(U.S. Patent 5,953,727)를 예로 들 수 있으며, 이는 그 전체가 참조로서 여기에 합체된다.
본 발명의 데이터베이스는 외부의 데이터베이스에 접속될 수도 있다. 바람직한 실시예에서, 표 1에 기재되어 있는 것과 같이, 외부 데이타베이스는 GenBank, 및 이와 연관된 국립생물정보학센타(National Center for Biotechnology Information) 또는 NCBI(http://www.ncbi.nlm.nih.gov/Entrez)에 의해 운영되는 관련 데이터베이스이다. 본 발명에서 사용될 수도 있는 다른 외부 데이터베이스로는 Chemical Abstracts Service(http://stnweb.cas.org/) 또는 Incyte Genimics(http://www.incyte.com/sequence/index.shtml)에서 제공하는 것들이다.
서열 정보, 유전자 발현 정보, 및 데이터베이스내 또는 입력으로서 제공되는 기타 다른 정보 사이의 필요한 비교를 수행하기 위하여 적절한 컴퓨터 플랫폼이 사용될 수도 있다. 예를 들어, 수많은 컴퓨터 워크스테이션들이 다양한 제작자들로부터 얻어질 수 있으며, 이는 실리콘 그래픽스(Silicon Graphics)로부터도 가능하다. 클라이언트-서버 환경, 데이터베이스 서버 및 네트워크가 또한 널리 이용가능하고, 이들은 본 발명의 데이터베이스를 위한 적절한 플랫폼들이다.
본 발명의 데이터베이스는, 다른 것들 중에서, 사용자가, 주어진 유전자가 발현되는 세포의 유형 또는 조직을 결정하게 하고, 특정 조직 또는 세포에서의 주어진 유전자의 발현 또는 그것이 없음을 결정하도록 해주는 electronic Norther Blots(E-Northerns)를 생성하는데 사용도리 수도 있다. E-northern 분석은, 간, 신장, 심장과 같은 조직에서 과발현하지 않는 조직 특이적 후보 치료적 표적들(tissue specific candidate therapeutic targets)을 발견하기 위한 도구로서 사용될 수 있다. 이러한 조직 타입은 약제가 한번 개발되면 종종 결정적인 부작용을 유발하며, 표적 발견 및 실증 과정에서 조기에 이들 타겟들을 제거하기 위한 퍼스트-패스 스크린(first-pass screen)은 유익할 것이다.
또한, 본 발명의 데이터베이스는, 표 1의 적어도 하나의 유전자를 포함하는 것으로 구성되어 있는 유전자 셋트의 조직 또는 세포에서의 발현 레벨을 확인하는데 사용될 수도 있다. 표 1의 적어도 하나의 유전자의 발현 레벨을 데이터베이스내 유전자의 발현 레벨와 비교하는 단계를 포함하는 것으로 구성되어 있다. 이러한 방법은 샘플로부터의 표 1의 유전자 또는 유전자 세트들의 발현 레벨과 정상 간 조직과 종양 조직, 또는 둘 모두에서 발견되는 발현 레벨과 비교함으로써 주어진 조직의 생리학적 상태를 예견하는 데 사용될 수도 있다. 이러한 방법은 또한 여기서 설명하는 것과 같은 약제 또는 작용제의 스크리닝 방법에도 사용될 수 있다.
더 자세한 설명이 필요 없이도, 당업자들은 상기의 설명과 하기의 설명적인 예들을 이용하여, 본 발명의 화합물들을 제작하고 사용할 수 있으며 청구된 방법들을 실행할 수 있을 것으로 믿어진다. 그러므로 상기의 예들은 단지 설명적인 것이며, 본 발명의 범위를 어떤 식으로든 제한하는 것으로 해석되어서는 아니하다.
실시예 1: 간암 프로파일의 제작
조직 샘플의 획득과 제작
환자의 조직 샘플은 10 명의 한국인 환자들로부터 얻어졌으며, 이들은 34 내지 65 세의 사람들로 각 5 명씩 두 군으로 분류하였다. 각각의 군은 4 명의 남자와 1 명의 여자로 구성되어 있었다. 그 중 한 군은 만성 B형 간염으로 진단되었고 후에 간암으로 발전한 환자들로 구성되어 있었다. 두 번째 군의 환자들은 간 경화로 진단되었다. 이들 또한 후에 간암으로 발전하였다. 각각의 환자에게서 생검 샘플의 세트를 구하기 위해 간 기관의 두 곳으로부터 조직을 회수하였다. 첫 번째 군에서, 샘들들은 간 종양, 및 염증(간염으로 인한 염증) 조직을 구성하는 비암화 주변 부위로부터 분리되었다. 두 번째 군(암/경화)에서, 간 조직은 종양, 및 섬유 조직을 구성하는 비암화 주변 부위(간 경화로 인한 섬유증 부위)로부터 분리되었다.
각 조직 샘플의 조직학적 검사을 수행하였고 비암화와 암화의 카테고리로 나누었다.
샘플의 제작은, 약간의 변형을 가한 상태로, Affymetric GeneChip Expression Analysis Manual의 방법을 따랐다. 우선, Spex Certiprep 6800 Freezer Mill을 사용하여 냉동 조직을 분쇄하였다. 전체 RNA는 Trizol(Life Techmology)을 사용하여 분리하였고 각 샘플의 전체 RNA의 양은 200-500 ㎍이었다.다음으로, mRNA는 Oligotex mRNA Midi kit(Quiagen)을 사용하여 분리하였다. 최종 400 ㎕의 양으로 mRNA을 추출하였기 때문에, 최종 농도가 1 ㎍/㎕의 농도가 되도록 에탄올 침전과정이 요구되었다. SuperScrip Choice system(Gibco-BRL)을 사용하여 1-5 ㎍의 mRNA을 이중가닥으로 cDNA로 만들었다. 제 1 가닥의 cDNA을 T7-(dT24) 올리고뉴클레오티드로 프라이밍시켰다. 그런 다음, 페놀-클로로포름으로 추출한 후 최종 농도가 1 ㎍/㎕가 되도록 에탄올 침전시킨다.
표준 과정에 따라 2 ㎍의 cDNA로부터 cDNA가 합성되었다. cDNA에 바이오틴(biotin)을 표지하기 위하여, 뉴클레오티드 Bio-11-CTP 및 Bio-16-UTP(Enzo Diagnostic)를 반응액에 첨가하였다. 37℃에서 6 시간 반응시킨 후, 표지된 cDNA는 Rneasy Mini kit protocol(Quiagen)의 방법에 따라 세척시킨다. cDNA를 94℃, 35 분 동안 분획시켰다 (5x 분획 버퍼: 200 mM Tris-Acetate(pH8.1), 500 mM KOAc 및 150 mM MgOAc).
분획된 55 ㎍의 cDNA는, 45℃ 혼성화 오븐에서 60 rpm으로 24 시간 동안, 인간 유전체 U95 세트의 어레이에서 혼성화되었다. 칩은 세착한 후 Affymetrix fluidics station에서 Streptavidin Phycoerythrin(SAPE)로 염색하였다. 염색의 극대화를 위해, 과정 사이에, SAPE용액을 anti-streptavidin biotinylated antibody(Vector LAboratories) 염색과정과 함께 2회 첨가하였다. 탐침자 어레이에 대한 혼성화는 형광 스캐닝(Hewlett Packard Gene Array Scanner)에 의해 탐지되었다. 혼성화와 스캐닝 과정을 마친 후, 마이크로어레이 이미지를 품질 제어(quality control)를 위해 분석하여, 혼성화 신호에서 주요 칩 결점들과 비정상적인 것들을 찾아내었다. 모든 칩에 대한 QC 과정을 거친 후, 데이터는 Affymetrix GeneChip software(v3.0) 과 Experimental Data Mining Tool(EDMT) software(v1.0)을 사용하여 분석하였다.
유전자 발현 분석
모든 샘플은 상기에서 설명한 방법으로 준비하고, Affymetrix Human Genome U95 array 상에 혼성화시켰다. 각 칩은 각 유전자 또는 cDNA 클론 당 12-20 개의 올리고뉴클레오티드 프로브의 쌍을 포함하고 있다. 이들 프로브 쌍들은, 평균 차이값(difference)을 계산하기 위해 필요한, 완전히 일치하는 세트와 불일치하는 세트를 포함하고 있다. 평균 차이값은 각 프로브 쌍들의 강도의 차이의 측정값이고, 완전히 일치의 강도에서 불일치의 강도를 뺌으로써 계산된다. 이것은, 프로브 쌍들 및 형광 광도에 영향을 줄 수 있는 기타 거짓 혼성화들(artifact hybridization)에서의 다양성을 고려하는 것이다. 이렇게 계산된 평균 차이값을 사용함으로써, 각 유전자에 대한 절대적 신호(absolute call)가 만들어진다.
존재, 부재 또는 경계(marginal)에 대한 절대적 신호는, 그것에 따라, 주어진 샘플 셋트에 이들 유전자들이 보편적으로 존재하는지 보편적으로 존재하지 않는지를 확인하는데 사용되는 도구인 Gene Signature를 생성하는데 사용된다.
Gene Signature 곡선은, 특정 샘플 셋트에서 보편적으로 발현되는 유전자들을 고려하고, 발현이 이들 샘플들에서 변화하는 유전자들을 차감하여, 샘플 크기가 증가함에 따라 주어진 샘플에 일정하게 존재하는 유전자들의 수에 대해 그래프 도식이다. 또한 이러한 곡선은 정확한 Gene Signature를 생성하는데 필요한 샘플의 수를 나타낸다. 샘플의 수가 증가함에 따라, 샘플 집단에 보편적으로 존재하는 유전자들의 수는 감소한다. 곡선은, Gene Signature에 한번에 하나의 샘플을 부가하고, 현재 샘플들의 가장 적은 수를 가진 샘플로부터 시작하여 적어지는 순서로 샘플들을 부가함으로써 결정되는, 문제된 샘플들의 positive Gene Signature를 사용하여, 만들어진다. 이러한 곡선은, 가장 일관성 있고 샘플들 간에 발현의 다양성이 가장 적은 것에 요구되는 샘플 크기를 나타낸다. 곡선의 레벨이 감소하는 지점은 Gene Signature에 요구되는 샘플들의 최저 수를 나타낸다. X축은 세트에 있는 샘플의 수를 나타내고, Y축은 양성 Gene Signature에 있는 유전자들의 수를 나타낸다. 일반적으로, 두 샘플 사이의 양성 유전자들의 수에 있어서의 허용하는 다양성의 백분율은 5% 미만이어야 한다.
본 실험의 이러한 목적을 위해, 하기의 통계학적 방법이 데이터 분석에 사용되었다. 유전자 셋트는 샘플들의 적어도 하나의 군에서 현재 신호들의 어떠한 백분율 가지는 유전자들로 구성되어 있다. 이러한 유전자들은 분석되고, 또 다른 유전자들은 제외된다. 예를 들어, 간염이나 간경화 환자들로부터의 암화 세포들, 또는 이들 유형 중의 어느 환자로부터의 비암화 세포들에서, 적어도 하나의 군에서 40%(5 개의 샘플 중의 2 개의 샘플) 존재 신호를 가진 유전자는, 만약 40%가 퍼센트 존재 신호들의 최저 한계 보다 높다면 분석에 포함된다. 또한, 유전자들은 샘플들에서의 발현값에 따라 두 군으로 나뉜다. 고 발현군의 유전자에서는, 분석 전에 평균 차등 값을 로그 스케일(log scale)로 변화시킨다. 저 발현군의 유전자에서는, 원래의 값을 분석에 사용한다. 변화 분석(ANOVA; Analysis of Variance)의 방법이 데이터 분석에 사용된다(Steelet al., Principle and Procedures of Statistics; A Biometrical Approach, Third Ed., McGraw-Hill,1997). 최종 분석하기 전에, leave-one-out 접근법이 특이값 검출(outlier detection)에 사용된다. 분석에서 어떤 특정 샘플을 제거하는 것이 최종 결과에 중요한 영향을 미칠 수 있는 지를 알아보기 위하여 하나의 샘플을 ANOVA 분석으로부터 제거한다. 만약 그렇다면, 상기의 특정 샘플은 최종 분석에서 제외시킨다. 특이값이 검출 후, 최종 분석은, ANOVA로부터의 대비에 의해 결정되는, p-수치 ≤ 0.001로 차등 발현되는 유전자들의 리스트를 만들어 낸다.
차등 발현된 유전자들은, 원발성 간암(세포성 간암 또는 HCC)로 진행된, 만성 간염(CH) 또는 간 경화(LC) 환자들에서 동일한 간의 암화 및 비암화 부위들로부터 얻어진 생검 샘들을 비교함으로써 발견되었다. 암화 및 비암화 샘들간에 차이를 보이지 않은 유전자들은 표 1에 포함시키지 않았다. 표 1의 군 1(23 개 유전자)은, 염증 부위 또는 섬유성 부위로부터 얻은 비암화 세포들에서의 레벨에 대해 간 종양 세포들에서의 레벨을 비교하였을 때, 다르게 발현된 것으로 확인된 유전자들을 나타내고 있다. 군 2(12 개 유전자)는, 염증 부위로부터 얻은 세포과 비교하여 간 종양 세포들에서 다랐던 발현 레벨을 가진 유전자들을 나타내고 있으며, 군 3은 간의 섬유성 조직으로부터 얻은 세포들과 비교하여 간 종양 세포들에서 다랐던 발현 레벨을 가진 유전자들을 포함하고 있다.
폴드 변화 분석
우선, 어떠한 샘플에서도 발현되지 않는 유전자들을 데이터에서 제외시켰다. 비율(종양성/비종양성, HCC/CH 또는 HCC/LC)은 종양 샘플의 각 유전자들의 평균 발현 수치와 비종양성 샘플 셋트의 유전자의 평균 발현 수치를 비교함으로써 계산되었다. 만약 유전자들이, ANOVA 분석에 의해 결정할 때, 둘 중의 어느 한 방향에서 폴드 변화 ≥1.5 와 p-수치<0.0007을 가질 때에는, 분석에 포함시켰다. 시험의 기준에 따라, 0.0007 미만의 p-수치를 가지는 차이는 통계학적으로 유의한 것으로 결정하였다. 인간 유전체 U95에 의해 조사된 ~60,000 개의 유전자들로부터, 109 개의 유전자들이 전반적인 폴드 변화 분석에서 존재하였다. 표 1에서, 두 질병 상태의 간 생검 샘플들에 대한 질환상태의 유전자 발현의 레벨간의 비교 또는 폴드 변화를 나타내는 숫자들은 양성 또는 음성일 수 있다. 양성 수치는 대조군(up-regulation)에 비해 종양 샘플에서 높은 발현을 나타내는 것이고, 반면 음성 수치는 종양 샘플(down-regulation)에서 낮은 발현 레벨을 나타내는 것이다.
간암에서 달리 발현되는 유전자들의 발현 프로파일
상기에서 설명한 방법을 사용하여, 간암에서 우세하게 과발현되는 유전자 또는 과발현되지 않는 유전자들을 나타내었다. 발현의 차이가 일정한 유전자들은 넓은 범위의 진단과 치료를 위한 잠재적인 표적으로 제공한다.
표 1은, 각 유전자의 폴드 변화 값을 가지고, 비암화 간 조직과 비교하여 암화 간 조직에서 차등 발현되는 유전자들인 것으로 결정된 유전자 세트를 보여주고있다. 더욱 상세하게는, 간암 세포들에서 표 1의 유전자들의 발현 레벨을, 간의 염증 및/또는 섬유성 부위로부터 얻은 조직에서의 발현 레별과 비교하였다. 각 유전자의 상대적 발현 수치와 함께, 이러한 유전자 집단들은, 검사한 질환들, 간암 발암성을 가진 만성 간염 및 간암 발암성을 가진 간 경화에 대한 프로파일을 생성한다.
표 1의 유전자들 또는 유전자들의 서브셋트는 전반적인 간 질환 유전자 발현 프로파일을 확인시킨다. 표 1의 유전자들은 단독으로, 또는 본 발명의 사용방법, 조성물, 데이터베이스 및 컴퓨터 시스템과 함께 사용할 수도 있다.
실험예 2: 유전자 집단 분석과 관련된 간 질환의 진단학적 집합
표 1은 군 2와 3(각각 12 개 및 74 개의 유전자)에서 p-수치에 의해 선택된 유전자들의 진단학적 서브셋트들의 구성원들을 나타내고 있다. 진단, 모니터링, 약제의 스크리닝 및 치료적 용도 이외에, 이들 유전자 군들은, 만성적 간염을 가진 객체들로부터의 간 종양 샘플들과, 간 경화를 가진 객체들로부터의 간 종양 샘들들을 차등화시키는데 사용될 수 있다. 이들 유전자들의 발현 레벨을 측정하는 분석방법은 만성 간염 환자들에서 유발되는 암과 간 경화 환자들에서 유발되는 암을 구별할 수 있다.
따라서, 표 1 유전자 서브셋트들은, 만성 간염 환자 또는 간 경화 환자의 간 조직의 악성 종양의 존재 유무를 확인하고, 종양의 진행 상태(예를 들어, 암 치료 또는 합병증 질환 치료 기간 동안)를 모니터링하며, 종양 치료를 위한 치료제들의효과를 평가하거나, 또는 종양의 근원 또는 이를 유발하는 조건을 구분하는데 사용될 수 있다.
본 발명이 상기의 실시예들을 참조로 자세히 설명되었지만, 다양한 방법이 본 발명의 개념에서 벗어나지 않고 행해질 수 있음을 이해할 수 있을 것이다. 따라서, 본 발명은 하기의 청구범위에 의해서만 제한된다. 여기에서 인용된 모든 특허들과 본 발명에서 언급한 논문 등의 자료들은 참조로서 여기에 합체된다.
SEQUENCE LISTING <110> LG BIOMEDICAL INSTITUTE GENE LOGIC, INC. <120> GENE EXPRESSION PROFILES IN LIVER DISEASE <130> LL04KR006P <150> US 60/341,815 <151> 2001-12-21 <150> US 60/343,185 <151> 2001-12-31 <160> 109 <170> PatentIn Ver. 2.1 <210> 1 <211> 3597 <212> DNA <213> Homo sapiens <220> <223> Genbank Accession No. AF034957 <400> 1 atggtggccg cagcggcggc aactgaggca aggctgagga ggaggacggc ggcgacggca 60 gcgctcgcgg gcaggagcgg cgggccgcac tgtgtcaacg gcggtcgctg caaccctggc 120 accggccagt gcgtctgccc cgccggctgg gtgggcgagc aatgccagca ctgcgggggc 180 cgcttcagac taactggatc ttctgggttt gtgacagatg gacctggaaa ttataaatac 240 aaaacgaagt gcacgtggct cattgaagga cagccaaata gaataatgag acttcgtttc 300 aatcattttg ctacagagtg tagttgggac catttatatg tttatgatgg ggactcaatt 360 tatgcaccgc tagttgctgc atttagtggc ctcattgttc ctgagagaga tggcaatgag 420 actgtccctg aggttgttgc cacatcaggt tatgccttgc tgcatttttt tagtgatgct 480 gcttataatt tgactggatt taatattact tacagttttg atatgtgtcc aaataactgc 540 tcaggccgag gagagtgtaa gatcagtaat agcagcgata ctgttgaatg tgaatgttct 600 gaaaactgga aaggtgaagc atgtgacatt cctcactgta cagacaactg tggttttcct 660 catcgaggca tctgcaattc aagtgatgtc agaggatgct cctgcttctc agactggcag 720 ggtcctggat gttcagttcc tgtaccagct aaccagtcat tttggactcg agaggaatat 780 tctaacttaa agctccccag agcatctcat aaagctgtgg tcaatggaaa cattatgtgg 840 gttgttggag gatatatgtt caaccactca gattataaca tggttctagc gtatgacctt 900 gcttctaggg agtggcttcc actaaaccgt tctgtgaaca atgtggttgt tagatatggt 960 cattctttgg cattatacaa ggataaaatt tacatgtatg gaggaaaaat tgattcaact 1020 gggaatgtga ccaatgagtt gagagttttt cacattcata atgagtcatg ggtgttgttg 1080 acccctaagg caaaggagca gtatgcagtg gttgggcact ctgcacacat tgttacactg 1140 aagaatggcc gagtggtcat gctggtcatc tttggtcact gccctctcta tggatatata 1200 agcaatgtgc aggaatatga tttggataag aacacatgga gtatattaca cacccagggt 1260 gcccttgtgc aagggggtta cggccatagc agtgtttacg accataggac cagggcccta 1320 tacgttcatg gtggctacaa ggctttcagt gccaataagt accggcttgc agatgatctc 1380 taccgatatg atgtggatac ccagatgtgg accattctta aggacagccg atttttccgt 1440 tacttgcaca cagctgtgat agtgagtgga accatgctgg tgtttggggg aaacacacac 1500 aatgacacat ctatgagcca tggcgccaaa tgcttctctt cagatttcat ggcctatgac 1560 attgcctgtg accgctggtc agtgcttccc agacctgatt ccaccatgat gtcaacagat 1620 ttggccattc cagcagtctt acacaacagc accatgtatg tgttcggtgg tttcaatagt 1680 ctcctcctca gcgacatcct ggtattcacc tcggaacagt gtgatgcgca tcggagtgaa 1740 gccgcttgtt tagcagcagg acctggtatt cggtgtgtgt ggaacacagg gtcgtctcag 1800 tgtatctcgt gggcgctggc aactgatgaa caagaagaaa agttaaaatc agaatgtttt 1860 tccaaaagaa ctcttgacca tgacagatgt gaccagcaca cagattgtta cagctgcaca 1920 gccaacacca atgactgcca ctggtgcaat gaccattgtg tccccaggaa ccacagctgc 1980 tcagaaggcc agatctccat ttttaggtat gagaattgcc ccaaggataa ccctatgtac 2040 tactgtaaca agaagaccag ctgcaggagc tgtgccctgg accagaactg ccagtgggag 2100 ccccggaatc aggagtgcat tgccctgccc gaaaatatct gtggcattgg ctggcatttg 2160 gttggaaact catgtttgaa aattactact gccaaggaga attatgacaa tgctaaattg 2220 ttctgtagga accacaatgc ccttttggct tctcttacaa cccagaagaa ggtagaattt 2280 gtccttaagc agctgcgaat aatgcagtca tctcagagca tgtccaagct caccttaacc 2340 ccatgggtcg gccttcggaa gatcaatgtg tcctactggt gctgggaaga tatgtcccca 2400 tttacaaata gtttactaca gtggatgccg tctgagccca gtgatgctgg attctgtgga 2460 attttatcag aacccagtac tcggggactg aaggctgcaa cctgcatcaa cccactcaat 2520 ggtagtgtct gtgaaaggcc tgcaaaccac agtgctaagc agtgccggac accatgtgcc 2580 ttgaggacag catgtggaga ttgcaccagc ggcagctctg agtgcatgtg gtgcagcaac 2640 atgaagcagt gtgtggactc caatgcctat gtggcctcct tcccttttgg ccagtgtatg 2700 gaatggtata cgatgagcac ctgcccccct gaaaattgtt caggctactg tacctgtagt 2760 cattgcttgg agcaaccagg ctgtggctgg tgtactgatc ccagcaatac tggcaaaggg 2820 aaatgcatag agggttccta taaaggacca gtgaagatgc cttcgcaagc ccctacagga 2880 aatttctatc cacagcccct gctcaattcc agcatgtgtc tagaggacag cagatacaac 2940 tggtctttca ttcactgtcc agcttgccaa tgcaacggcc acagtaaatg catcaatcag 3000 agcatctgtg agaagtgtga gaacctgacc acaggcaagc actgcgagac ctgcatatct 3060 ggcttctacg gtgatcccac caatggaggg aaatgtcagc catgcaagtg caatgggcac 3120 gcgtctctgt gcaacaccaa cacgggcaag tgcttctgca ccaccaaggg cgtcaagggg 3180 gacgagtgcc agctatgtga ggtagaaaat cgataccaag gaaaccctct cagaggaaca 3240 tgttattata ctcttcttat tgactatcag ttcaccttta gtctatccca ggaagatgat 3300 cgctattaca cagctatcaa ttttgtggct actcctgacg aacaaaacag ggatttggac 3360 atgttcatca atgcctccaa gaatttcaac ctcaacatca cctgggctgc cagtttctca 3420 gctggaaccc aggctggaga agagatgcct gttgtttcaa aaaccaacat taaggagtac 3480 aaagatagtt tctctaatga gaagtttgat tttcgcaacc acccaaatat cactttcttt 3540 gtttatgtca gtaatttcac ctggcccatc aaaattcagg tgcaaactga acaatga 3597 <210> 2 <211> 1231 <212> DNA <213> Homo sapiens <220> <223> Genbank Accession No. Z23090 <400> 2 gagggaactg gtaatagaat ttattcaaat gtgccttaat ataggcgctg gggcttgccc 60 atggtgctct tgatatataa ggcccggaca ttctgccagt ttttcttgag caatgacacc 120 aagaagttga cagccaggtg aatgttatac acaagctcat cgtctgtcat cttcacgtga 180 ccaacagcta cagccagaca taacaccttc ttcatttgga acttgattgt ggacttcacc 240 tcatccactt tggccaccat gttttcgttg tgtgtgagca gggaagggaa ctttcctgcc 300 ttatttaaac ctgggccgag gattcgtgga atctgcttga tcagagactc tgaggccaaa 360 acgcatcata cttcttggcc agcttcttga ccagtttttt attcttgttg agttttttca 420 gcgcctcgat gtccatgtgg gggatatcca cggccttagc ctcgtcaaga cccacaccag 480 agtcagccag catgaccgag cgccgcgtcc ccttctcgct cctgcggggc cccagctggg 540 accccttccg cgactggtac ccgcatagcc gcctcttcga ccaggccttc gggctgcccc 600 ggctgccgga ggagtggtcg cagtggttag gcggcagcag ctggccaggc tacgtgcgcc 660 ccctgccccc cgccgccatc gagagccccg cagtggccgc gcccgcctac agccgcgcgc 720 tcagccggca actcagcagc ggggtctcgg agatccggca cactgcggac cgctggcgcg 780 tgtccctgga tgtcaaccac ttcgccccgg acgagctgac ggtcaagacc aaggatggcg 840 tggtggagat caccggcaag cacgaggagc ggcaggacga gcatggctac atctcccggt 900 gcttcacgcg gaaatacacg ctgccccccg gtgtggaccc cacccaagtt tcctcctccc 960 tgtcccctga gggcacactg accgtggagg cccccatgcc caagctagcc acgcagtcca 1020 acgagatcac catcccagtc accttcgagt cgcgggccca gcttgggggc ccagaagctg 1080 caaaatccga tgagactgcc gccaagtaaa gccttagccc ggatgcccac ccctgctgcc 1140 gccactggct gtgcctcccc cgccacctgt gtgttctttt gatacattta tcttctgttt 1200 ttctcaaata aagttcaaag caaccacctg t 1231 <210> 3 <211> 488 <212> DNA <213> Homo sapiens <220> <223> Genbank Accession No. AA928646 <220> <221> unsure <222> (1)..(488) <223> n = a or c or g or t <400> 3 tgggtatttc actttattta gcaaacggtc acactcggcc ccaccacacc gcgcctgcag 60 cctcacttga gcatctgtct caggaagcag ctcagggtga acaggaaggc ctgggtttcc 120 cagttcaggc cttatccgtc gccacacgtg ccacacacca caaaacaaaa tcacttcccc 180 acgtcctcag gagcccaccc cagtgtggtc cgggggacgc tccagtgttc aacagctgcc 240 tgcaggggcc acagccagtc tgtagacaca ggccctggca cgaggcggtc ccgggtgtac 300 cacaaggcga tgcgtnctcc atggaggttc ttcttccctg tgccgtggac tttgaagtgg 360 acgtgcattt cccagtcttt gaggaagcac ggctggtggt tccagataga gccctctttg 420 ctgcgcccgt caggggtcag acgtacgtac tggctcgtga gcatagtgct gccctggaag 480 ttccagag 488 <210> 4 <211> 521 <212> DNA <213> Homo sapiens <220> <223> Genbank Accession No. AW023096 <220> <221> unsure <222> (1)..(521) <223> n = a or c or g or t <400> 4 gcacgagccc agcccgagtt atgcctgccc agcttaaggt cctaaccatg ccggagacct 60 gtngatacca gcctttnaaa ccactctcta ttggaggcat catcattctg aaggatacca 120 gtgaanacat tgaggagctg gtggaacctg tggcagcaca tggcccaaaa atcgaggagg 180 aggaacaaga gccagaaccc ccagaaccat ttgagtatat tgatgattaa nggccagagg 240 atctcacttg cttatctgaa gaagattgtc caggctcata ttgggaatgc ttatgaggaa 300 attcatgccg agacctgcta ttcaatgcat gtatcgttgc ctctgcactg acctgaagaa 360 ccctgtcttc caagtctttt ggttgaaaga gaagatatan tgactgttng agttgtggct 420 cttttacaag aaacnttngn ntttcaaata aatattaaag atctttccng atggacnngg 480 aaaaanatta aacacttatt ttcctcgagg gggggggccc c 521 <210> 5 <211> 619 <212> DNA <213> Homo sapiens <220> <223> Genbank Accession No. AA399076 <400> 5 caactagggg gaaaacactt taggttgagt gctgagagaa aggctctctg agtaggtgac 60 atctgaacta agagctgaag cagaagaata agccatcctc tgtggaccaa aggggacaag 120 attctctact tttctgctac gcactaggaa tatagcagag aagacaagtg gctgctacct 180 tctgttatcg tgggtggcag tgactagttt ttctagatct tgactccctg ccgtaactaa 240 agatggagta cactgatgct gaagtactat gagccttcgg aacttgtgga gagactacaa 300 agttttggtt gttatggtcc ctttagttgg gctcatacat ttggggtggt acagaatcaa 360 aagcagccct gttttccaaa tacctaaaaa cgacgacatt cctgagcaag atagtctggg 420 actttcaaat cttcagaaga gccaaatcca ggggaagtag caggcttgca atcttcaggt 480 aaagaagcag ctttgaatct gagcttcata tcgaaagaag agatgaaaaa taccagttgg 540 attagaaaga actggcttct tgtagctggg atatctttca taggtgtcca tcttggaaca 600 tactttttgc agaggtctg 619 <210> 6 <211> 509 <212> DNA <213> Homo sapiens <220> <223> Genbank Accession No. U39317 <400> 6 gcacgggtca ccgcatcaca ccatggctct gaagagaatc cacaaggaat tgaatgatct 60 ggcacgggac cctccagcac agtgttcagc aggtcctgtt ggagatgata tgttccattg 120 gcaagctaca ataatggggc caaatgacag tccctatcag ggtggagtat ttttcttgac 180 aattcatttc ccaacagatt accccttcaa accacctaag gttgcattta caacaagaat 240 ttatcatcca aatattaaca gtaatggcag catttgtctt gatattctac gatcacagtg 300 gtctccagca ctaactattt caaaagtact cttgtccatc tgttctctgt tgtgtgatcc 360 caatccagat gatcctttag tgcctgagat tgctcggatc tacaaaacag atagagaaaa 420 gtacaacaga atagctcggg aatggactca gaagtatgcg atgtaattaa acaaattatt 480 ggataacctc tacaaataaa gatagggga 509 <210> 7 <211> 591 <212> DNA <213> Homo sapiens <220> <223> Genbank Accession No. W74749 <220> <221> unsure <222> (1)..(591) <223> n = a or c or g or t <400> 7 gatagtaaaa taattttatt tagtttctta ttttaaaaaa ggtagcattt caacatataa 60 atttagactc aagattacag tgtatatttg ccaaaaggaa caccccgaaa gacggccagc 120 ctcagagctg agagggcaca gggaggcaca ctcctcacac atggagttta agcagaagtg 180 ctttaagact tcacagcggc atttccctgt tcctcagccc cgcctccagg gccatcactt 240 tggggcaaca gcttttgctc atgtaactat aaaacatctc taggaatgaa agcacagagg 300 tcaatgatcc agattttcca caacaatcat ctgcagcaac aattcgacag gtaaagattt 360 tatttttata attcaaaagt tcttttaagg agaactaaag aacacaaaat tcatttataa 420 agagatttat agaattaaat ggagccaaaa tggaaaaatt attttcccca tattaccaat 480 ggcctctata nggataaggn ccagggggga agacccattt ccaatctggg ctttcccttc 540 cccaataagt gttttgggca caacccacaa ctggtcatga gctgncaggc c 591 <210> 8 <211> 532 <212> DNA <213> Homo sapiens <220> <223> Genbank Accession No. AI916306 <400> 8 ttaccaattt aataaatgta ctgtattaac atgaagacta atgacaaatg cactgcagta 60 gtaagcacgt catagatgca tagaatattc tctatatagt ctgaatatgg atataaaata 120 agttatactc attttgtttt ccatcacagt aggagcatag catacaaagt gattggttca 180 gtggccatga agcaagccag gggagagacc acagaagaga atgtagggca ttgagtacag 240 tggggatttg ccaaggacac tgcagagtcc ctggggaccc tctggggaac aaggccccaa 300 acctctcaag ttagccttct gagaatagta tgaggtccca cttgacaaga gacagtggct 360 gcatctgagc tgggatgatt caggcaactg ggtgggaggc agagcaggga caggcacgaa 420 cagcatccag caggctagcc cactctcctg ctggtgctgt tggatgtcta tgatgctggg 480 aatatggggc gcagagccag aaggcacggt ttgcttctgt gacgtgacag at 532 <210> 9 <211> 2834 <212> DNA <213> Homo sapiens <220> <223> Genbank Accession No. X77777 <400> 9 tcggagcctg cggagggtgg tggtggtggt ggtggtggcc ctcgcccgcc tcactcatgc 60 ctcctcctcc tctgctctcg ctcaggcgcc tcggtggcgg ttggtcggcg gttacgcggc 120 tggtggtcgc ggcggccggg gctcgctctc ggggaggccg gggcggatct cgcggcgcag 180 gcggcggcgg ccgaggtggg gtcgcgcggc ggaggcggct cgagcttcgt gctgcgcgct 240 cgctcttggg ctcctcgctg caggaggagt gtgactatgt gcagatgatc gaggtgcagc 300 acaagcagtg cctggaggag gcccagctgg agaatgagac aataggctgc agcaagatgt 360 gggacaacct cacctgctgg ccagccaccc ctcggggcca ggtagttgtc ttggcctgtc 420 ccctcatctt caagctcttc tcctccattc aaggccgcaa tgtaagccgc agctgcaccg 480 acgaaggctg gacgcacctg gagcctggcc cgtaccccat tgcctgtggt ttggatgaca 540 aggcagcgag tttggatgag cagcagacca tgttctacgg ttctgtgaag accggctaca 600 ccattggcta cggcctgtcc ctcgccaccc ttctggtcgc cacagctatc ctgagcctgt 660 tcaggaagct ccactgcacg cggaactaca tccacatgca cctcttcata tccttcatcc 720 tgagggctgc cgctgtcttc atcaaagact tggccctctt cgacagcggg gagtcggacc 780 agtgctccga gggctcggtg ggctgtaagg cagccatggt ctttttccaa tattgtgtca 840 tggctaactt cttctggctg ctggtggagg gcctctacct gtacaccctg cttgccgtct 900 ccttcttctc tgagcggaag tacttctggg ggtacatact catcggctgg ggggtaccca 960 gcacattcac catggtgtgg accatcgcca ggatccattt tgaggattat ggtctgctca 1020 ggtgctggga caccatcaac tcctcactgt ggtggatcat aaagggcccc atcctcacct 1080 ccatcttggt aaacttcatc ctgtttattt gcatcatccg aatcctgctt cagaaactgc 1140 ggcccccaga tatcaggaag agtgacagca gtccatactc aaggctagcc aggtccacac 1200 tcctgctgat ccccctgttt ggagtacact acatcatgtt cgccttcttt ccggacaatt 1260 ttaagcctga agtgaagatg gtctttgagc tcgtcgtggg gtctttccag ggttttgtgg 1320 tggctatcct ctactgcttc ctcaatggtg aggtgcaggc ggagctgagg cggaagtggc 1380 ggcgctggca cctgcagggc gtcctgggct ggaaccccaa ataccggcac ccgtcgggag 1440 gcagcaacgg cgccacgtgc agcacgcagg tttccatgct gacccgcgtc agcccaggtg 1500 cccgccgctc ctccagcttc caagccgaag tctccctggt ctgaccacca ggatcccagc 1560 ccaagcggcc cctcccgccc cttcccactc gcagcagacg ccggggacag aggcctgccc 1620 gggcgcgcca gccccggccc tgggctcgga ggctgccccc ggccccctgg tctctggtcc 1680 ggacactcct agagaacgca gccctagagc ctgcctggag cgtttctagc aagtgagaga 1740 gatgggagct cctctcctgg aggatgcagg tggaactcag tcattagact cctcctccaa 1800 aggcccccta cgccaatcaa gggcaaaaag tctacatact ttcatcctga ctctgccccc 1860 tgctggctct tctgcccaat tggaggaaag caaccggtgg atcctcaaac aacactggtg 1920 tgacctgagg gcagaaaggt tctgcccggg aaggtcacca gcaccaacac cacggtagtg 1980 cctgaaattt caccattgct gtcaagttcc tttgggttaa gcattaccac tcaggcattt 2040 gactgaagat gcagctcact accctattct ctctttacgc ttagttatca gctttttaaa 2100 gtgggttatt ctggagtttt tgtttggaga gcacacctat cttagtggtt ccccaccgaa 2160 gtggactggc ccctgggtca gtctggtggg aggacggtgc aacccaagga ctgagggact 2220 ctgaagcctc tgggaaatga gaaggcagcc accagcgaat gctaggtctc ggactaagcc 2280 tacctgctct ccaagtctca gtggcttcat ctgtcaagtg ggactctgtc acaccagcca 2340 ttcttatctc tctgtgctgt ggaagcaaca ggaatcaaga gactgccctc cttgtccacc 2400 cacctatgtg ccaactgttg taactaggct cagagatgtg cacccatggg ctctgacaga 2460 aagcagatcc tcaccctgct acacatacag gatttgaact cagatctgtc tgataggaat 2520 gtgaaagcac ggactcttac tgctaacttt tgtgtatcgt aaccagccag atcctcttgg 2580 ttatttgttt accacttgta ttattaatgc cattatccct gaattcccct tgccacccca 2640 ccctccctgg agtgtggctg aggaggcctc catctcatgt atcatctgga taggagcctg 2700 ctggtcacag cctcctctgt ctgcccttca ccccagtggc cactcagctt cctacccaca 2760 cctctgccag aagatcccct caggactgca acaggcttgt gcaacaataa atgttggctt 2820 ggaaaaaaaa aaaa 2834 <210> 10 <211> 2799 <212> DNA <213> Homo sapiens <220> <223> Genbank Accession No. X63359 <400> 10 ctgcacaagg atggctctga aatggactac agttctgctg atacaactca gtttttactt 60 tagctctggg agttgtggaa aggtgctggt atgggccgca gaatacagcc tttggatgaa 120 tatgaagaca atcctgaaag aacttgttca gagaggtcat gaggtgactg tactggcatc 180 ttcagcttcc attctttttg atcccaacga ctcatccact cttaaacttg aagtttatcc 240 tacatcttta actaaaactg aatttgagaa tatcatcatg caattggtta agagattgtc 300 agaaattcaa aaagatacat tttggttacc tttttcacaa gaacaagaaa tcctgtgggc 360 aattaatgac ataattagaa acttctgtaa agatgtagtt tcaaataaga aacttatgaa 420 aaaactacaa gagtcaagat ttgacatcgt ttttgcagat gcttatttac cctgtggtga 480 gctgctggct gagctattta acataccctt tgtgtacagt cacagcttca gtcctggcta 540 ctcatttgaa aggcacagtg gaggatttat tttccctcct tcctacgtac ctgttgttat 600 gtcaaaatta agtgatcaaa tgactttcat ggagagggta aaaaatatgc tctatgtgct 660 ttattttgac ttttggttcc aaatatttaa tatgaagaag tgggatcagt tttacagtga 720 agttttagga agacccacta cattatctga gacaatgagg aaagctgaca tatggcttat 780 gcgaaactcc tggaatttta aatttcctca tccattctta ccaaatgttg attttgttgg 840 aggactccac tgcaaacctg ccaaacccct acctaaggaa atggaggagt ttgtacagag 900 ctctggagaa aatggtgttg tggtgttttc tctggggtca atggtcagta acatgacaga 960 agaaagggcc aacgtaattg caacagccct tgccaagatc ccacaaaagg ttctttggag 1020 atttgatggg aataaaccag atgccttagg tctcaatact cgactgtaca agtggatacc 1080 ccagaatgac cttctaggtc atccaaaaac cagagctttt ataactcatg gtggagccaa 1140 tggcatctat gaggcaatct accatgggat ccctatggtg ggcattccat tgttttttga 1200 tcaacctgat aatattgctc acatgaaggc caagggagca gctgttagag tggacttcaa 1260 cacaatgtcg agtacagacc tgctgaatgc actgaagaca gtaattaatg atccttcata 1320 taaagagaat attatgaaat tatcaagaat tcaacatgat caaccagtga agcccctgga 1380 tcgagcagtc ttctggattg aatttgtcat gcgccacaaa ggagccaaac atcttcgagt 1440 tgcagcccac aacctcacct ggttccagta ccactctttg gatgtgattg ggttcctgct 1500 ggcttgtgtg gcaaccgtgc tatttatcat cacaaagtgt tgtctgtttt gtttctggaa 1560 gtttgctaga aaaggaaaga agggaaaaag ggattagtta tatctgagat ttgaagctgg 1620 ggaattccgt ttattgaaga ttcaggttaa cctgaatcaa gttaacccag tctcaaatgc 1680 tcacttatcc tatctccttg gcacaaatct ctcctctcct ggattgccaa agaaaattca 1740 aattattctt caattagtca ggatgatttg actatcagca gttcatagta cccatcttca 1800 taactaagcc acctagggat ccggcagaaa aaaaagggat gcaggggagt catcatacag 1860 ggggtggatc atttaccagg atccacactt cctacaaagc ggttgtaata ttaaataaca 1920 aaactgtttt ttattccaat cttcacataa aacaggaata attgtatact ttcttactaa 1980 tgtgttccat ggagtttttc ctccaagaag tggcttaggg gaaaatgagc cccagtaatg 2040 ctctgtggca tccaatcctt ctaccccgac cctttgactt tctgccccag cccctcttag 2100 ttctcctaga attaggacta aggttaagtg ccctcttggg atatgacttc cttcccttcc 2160 tcttgataca aaaagagcct attaccaacc ctcatacaca caagagttcc cttcctagtt 2220 gcagactctt ctgctccagc tggactcccc tagctctgga ctcccactag atcacacagg 2280 ggtccctgca tgtcagtaaa ctttggatga ccttgggaga ccaaaaaatg gaatatcatt 2340 ttttgatcta aacaaaatag tttcctgatt taacactggc caggaaggtg ggctgcaccc 2400 tcagtctctc tctcccatca tggttttcac atgatatcaa aggactctca taacagtctg 2460 attcttatga gttgggcatc ctgtgtttcc ctttagggcc tgcttccttc aaatagagga 2520 gatgggtgct atgaaaccta ttcactctgg acttgggatg gctcttctcc atcttcccaa 2580 gtctgagctg gagcctccat gcccaactct gctctgctct tctatttcct gacagcagct 2640 aaggcatgtt cctgttctgc ccccaaattg accttactaa cagtgagaac ttggaggagt 2700 cttcgggtct tgggaaatcc aagttttccc ggaaacgttt tgttgtaaac agtgtccaca 2760 ctctttgctc caataaagct cggttcctta agggaattc 2799 <210> 11 <211> 2194 <212> DNA <213> Homo sapiens <220> <223> Genbank Accession No. Z48475 <400> 11 gtgaccagag gggtttgtgt ggctgaagag gcaggaggaa cagtgtatcc acagcgtggg 60 accatgccag gcacaaaacg gtttcaacat gtcattgaga ccccggagcc tggcaagtgg 120 gagttgtctg ggtacgaggc agctgtgcca atcacggaga agtcaaaccc actgacccag 180 gatctagaca aagcagatgc tgagaacatt gttcgactgc tagggcaatg tgatgctgag 240 atcttccagg aggaggggca agccctgtcc acataccaga gactctacag cgaatccatt 300 ctgaccacca tggtacaggt ggctgggaaa gttcaggaag tgctgaagga gccagatggg 360 gggctggttg tgctgagtgg agggggcacc tctggccgga tggcattcct catgtcggtg 420 tcctttaatc agctgatgaa aggtctggga cagaaacctc tttacaccta cctcattgca 480 ggtggtgaca ggtctgtggt ggcctctagg gaggggacag aagatagtgc cttgcacggg 540 attgaggaac tgaagaaggt ggctgccggg aagaagagag tgattgtcat tggcatttct 600 gtgggactct ctgctccctt tgtggcaggc cagatggact gctgcatgaa caacacagct 660 gtcttcttgc cagtcctggt tggcttcaat ccagtgagca tggccagaaa tgaccccatt 720 gaagactgga gttcaacatt ccgacaagta gcagagcgga tgcagaaaat gcaggagaaa 780 cagaaagctt ttgtgctcaa tcctgccatc gggcccgagg gtctcagcgg ctcctcccgg 840 atgaaaggtg gaagtgccac caagattctg ctggaaaccc tgttattagc agcccataag 900 actgtggacc agggcattgc agcatctcaa agatgcctcc tggaaatctt gcggacattt 960 gagcgagctc atcaggtgac ctacagccaa agccccaaga ttgccaccct gatgaagagt 1020 gtcagcacca gtctggagaa gaaaggccac gtgtacctgg ttggctggca gaccctgggt 1080 atcattgcca tcatggatgg agtagagtgc atccacacct ttggtgctga tttccgagat 1140 gtccgtggct ttctcattgg tgatcacagt gacatgttta accagaaggc tgagctcacc 1200 aaccagggtc cccagttcac cttctcccag gaggacttcc cgacttccat ccttccctct 1260 ctcacggaaa tcgatactgt ggtcttcatt ttcaccctgg atgacaacct cacggaggtg 1320 cagactatag tggagcaggt gaaagagaag accaaccaca tccaggccct ggcacacagc 1380 accgtgggtc agaccttgcc gatccctctg aagaagctct ttccctccat catcagcatc 1440 acatggccac tgcttttctt tgaatatgaa gggaacttca tccagaagtt ccagcgtgag 1500 ctaagcacca aatgggtgct gaatacagtg agtacaggtg ctcatgtgct tcttggtaag 1560 atcctacaaa accacatgtt ggaccttcgg attagcaact ccaagctctt ctggcgggcg 1620 ctggccatgc tgcagcggtt ctctggacag tccaaggctc gatgcatcga gagcctcctc 1680 cgagcgatcc actttcccca gccactgtca gatgatattc gggctgctcc catctcctgc 1740 cgtgtccagg ttgcacatga gaaggaacag gtgataccca tcgccttgct gagcctccta 1800 ttccggtgct cgatcactga ggctcaggca cacctggctg cagctccttc tgtctgtgag 1860 gctgtcagga gtgctcttgc tgggccaggt cagaagcgca ctgcggaccc cctcgagatc 1920 ctagagcctg acgttcagtg aacccatgtt tctgggtggg tgaaaggggc ccaaccctgc 1980 ccacttcagc ccagcccgcc caaggggact tgtgccagca gaacatgtgg gaggaagaag 2040 ccccgtttcc agggcatccg cagcccaggg tagggagaaa tattctctcc actttggggg 2100 agagttcttg ctctcgacct agtggtttct actctcaccg acttattctg atttcagaaa 2160 taaaatgaaa tgtcttattt tggaaaaaaa aaaa 2194 <210> 12 <211> 2171 <212> DNA <213> Homo sapiens <220> <223> Genbank Accession No. U17418 <400> 12 tcaacacgtg aattcccaca gaagctgctc agggactatc catggcctcc ccgtggccaa 60 cttgagtctg ctctgcagct ttaggcccga cttggaaggc ccatgggctg cagatgagga 120 aactgaggtc cagacagccg aagagtggta gtgtccagga cacacaactg ggccggcggc 180 ggcggctgcc ccgagggacg cggccctagg cggtggcgat ggggaccgcc cggatcgcac 240 ccggcctggc gctcctgctc tgctgccccg tgctcagctc cgcgtacgcg ctggtggatg 300 cagatgacgt catgactaaa gaggaacaga tcttcctgct gcaccgtgct caggcccagt 360 gcgaaaaacg gctcaaggag gtcctgcaga ggccagccag cataatggaa tcagacaagg 420 gatggacatc tgcgtccaca tcagggaagc ccaggaaaga taaggcatct gggaagctct 480 accctgagtc tgaggaggac aaggaggcac ccactggcag caggtaccga gggcgcccct 540 gtctgccgga atgggaccac atcctgtgct ggccgctggg ggcaccaggt gaggtggtgg 600 ctgtgccctg tccggactac atttatgact tcaatcacaa aggccatgcc taccgacgct 660 gtgaccgcaa tggcagctgg gagctggtgc ctgggcacaa caggacgtgg gccaactaca 720 gcgagtgtgt caaatttctc accaatgaga ctcgtgaacg ggaggtgttt gaccgcctgg 780 gcatgattta caccgtgggc tactccgtgt ccctggcgtc cctcaccgta gctgtgctca 840 tcctggccta ctttaggcgg ctgcactgca cgcgcaacta catccacatg cacctgttcc 900 tgtccttcat gctgcgcgcc gtgagcatct tcgtcaagga cgctgtgctc tactctggcg 960 ccacgcttga tgaggctgag cgcctcaccg aggaggagct gcgcgccatc gcccaggcgc 1020 ccccgccgcc tgccaccgcc gctgccggct acgcgggctg cagggtggct gtgaccttct 1080 tcctttactt cctggccacc aactactact ggattctggt ggaggggctg tacctgcaca 1140 gcctcatctt catggccttc ttctcagaga agaagtacct gtggggcttc acagtcttcg 1200 gctggggtct gcccgctgtc ttcgtggctg tgtgggtcag tgtcagagct accctggcca 1260 acaccgggtg ctgggacttg agctccggga acaaaaagtg gatcatccag gtgcccatcc 1320 tggcctccat tgtgctcaac ttcatcctct tcatcaatat cgtccgggtg ctcgccacca 1380 agctgcggga gaccaacgcc ggccggtgtg acacacggca gcagtaccgg aagctgctca 1440 aatccacgct ggtgctcatg cccctctttg gcgtccacta cattgtcttc atggccacac 1500 catacaccga ggtctcaggg acgctctggc aagtccagat gcactatgag atgctcttca 1560 actccttcca gggatttttt gtcgcaatca tatactgttt ctgcaacggc gaggtacaag 1620 ctgagatcaa gaaatcttgg agccgctgga cactggcact ggacttcaag cgaaaggcac 1680 gcagcgggag cagcagctat agctacggcc ccatggtgtc ccacacaagt gtgaccaatg 1740 tcggcccccg tgtgggactc ggcctgcccc tcagcccccg cctactgccc actgccacca 1800 ccaacggcca ccctcagctg cctggccatg ccaagccagg gaccccagcc ctggagaccc 1860 tcgagaccac accacctgcc atggctgctc ccaaggacga tgggttcctc aacggctcct 1920 gctcaggcct ggacgaggag gcctctgggc ctgagcggcc acctgccctg ctacaggaag 1980 agtgggagac agtcatgtga ccaggcgctg ggggctggac ctgctgacat agtggatgga 2040 cagatggacc aaaagatggg tggttgaatg atttcccact cagggcctgg ggccaagagg 2100 aaaaacaggg aaaaaaagaa aaaaaaaaag aaaagaaaaa aaggaaaaaa aaaaaaaaaa 2160 aaaaaaaaaa a 2171 <210> 13 <211> 833 <212> DNA <213> Homo sapiens <220> <223> Genbank Accession No. S82240 <400> 13 cagaaattat ccagcaaatc tatcatggat cctaatcaga acgtgaaatg caagatagtt 60 gtggtgggag acagtcagtg tggaaaaact gcgctgctcc atgtcttcgc caaggactgc 120 ttccccgaga attacgttcc tacagtgttt gagaattaca cggccagttt tgaaatcgac 180 acacaaagaa tagagttgag cctgtgggac acttcgggtt ctccttacta tgacaatgtc 240 cgccccctct cttaccctga ttcggatgct gtgctgattt gctttgacat cagtagacca 300 gagaccctgg acagtgtcct caaaaagtgg aaaggtgaaa tccaggaatt ttgtccaaat 360 accaaaatgc tcttggtcgg ctgcaagtct gatctgcgga cagatgttag tacattagta 420 gagctctcca atcacaggca gacgccagtg tcctatgacc agggggcaaa tatggccaaa 480 cagattggag cagctactta tatcgaatgc tcagctttac agtcggaaaa tagcgtcaga 540 gacatttttc acgttgccac cttggcatgt gtaaataaga caaataaaaa cgttaagcgg 600 aacaaatcac agagagccac aaagcggatt tcacacatgc ctagcagacc agaactctcg 660 gcagttgcta cggacttacg aaaggacaaa gcgaagagct gcactgtgat gtgaatcttt 720 cattatcttt aatgaagaca aaggaatcta gtgtaaaaaa caacagcaaa caaaaaggtg 780 agtctaaatg aagtgcacag ccaaagtcat gtataccaga ggcttaggag gcg 833 <210> 14 <211> 1445 <212> DNA <213> Homo sapiens <220> <223> Genbank Accession No. AF017786 <400> 14 gagttggggc tggcgctccg gagttgctgg gctcagcgca gctcccattc attaaggaac 60 cagctgcgga ggaaggtggc cgagcgcccg cgctgcccac tcgctcgctc gcgcactcag 120 acgcgcgcca caacagcgcg ccccaagctg cgcagctctg caaaagtttc tgctcgggat 180 ctggctctct tccccttgga ctttagaacg atttagggtt gacagaggaa agcagaggcg 240 cgcaggagga gcagaaaaca ccaccttctg cagttggagg caggcagccc cggctgcact 300 ctagccgcct gggtgtgtgg ctgctgttgc gggacgtctt cgcggggcgg gaggctcgcg 360 ccgcagccag cgccatgcaa aactacaagt acgacaaagc gatcgtcccg gagagcaaga 420 acggcggcag cccggcgctc aacaacaacc cgaggaggag cggcagcaag cgggtgctgc 480 tcatctgcct cgacctcttc tgcctcttca tggcgggcct ccccttcctc atcatcgaga 540 caagcaccat caagccttac caccgagggt tttactgcaa tgatgagagc atcaagtacc 600 cactgaaaac tggtgagaca ataaatgacg ctgtgctctg tgccgtgggg atcgtcattg 660 ccatcctcgc gatcatcacg ggggaattct accggatcta ttacctgaag aagtcgcggt 720 cgacgattca gaacccctac gtggcagcac tctataagca agtgggctgc ttcctctttg 780 gctgtgccat cagccagtct ttcacagaca ttgccaaagt gtccataggg cgcctgcgtc 840 ctcacttctt gagtgtctgc aaccctgatt tcagccagat caactgctct gaaggctaca 900 ttcagaacta cagatgcaga ggtgatgaca gcaaagtcca ggaagccagg aagtccttct 960 tctctggcca tgcctccttc tccatgtaca ctatgctgta tttggtgcta tacctgcagg 1020 cccgcttcac ttggcgagga gcccggctgc tccggcccct cctgcagttc accttgatca 1080 tgatggcctt ctacacggga ctgtctcgcg tatcagacca caagcaccat cccagtgatg 1140 ttctggcagg atttgctcaa ggagccctgg tggcctgctg catagttttc ttcgtgtctg 1200 acctcttcaa gactaagacg acgctctccc tgcctgcccc tgctatccgg aaggaaatcc 1260 tttcacctgt ggacattatt gacaggaaca atcaccacaa catgatgtag gtgccaccca 1320 cctcctgagc tgtttttgta aaatgactgc tgacagcaag ttcttgctgc tctccaatct 1380 catcagacag tagaatgtag ggaaaaactt ttgcccgact gatttttaaa aaaaaaaaaa 1440 aaaaa 1445 <210> 15 <211> 388 <212> DNA <213> Homo sapiens <220> <223> Genbank Accession No. AI985046 <400> 15 tttttttaca tttcaaatat attttattac tttccatctt agaaagaata tgaaacctgc 60 atgcaatgct aatggtttct gacatgtaca tagcatataa cacagcagta caatgcggca 120 tatactgggg ggcagtgtgt ggagggggcg ttcttaaggg tatatgtaca gaggaaaggg 180 cgcatggtca tcttagcttt cgaaagagga ctgcactgtt taacattgaa gaattacatg 240 gggaatcaca aatatattgc tttagtactg catgttctgt tgtggtgagg gaaagaaaca 300 tgctttgaag gttttccctt gtcaacagaa tgtgtgtctg tagctgtgta ttgcgcatgt 360 attcatatat ttttaagttt tctcctaa 388 <210> 16 <211> 2244 <212> DNA <213> Homo sapiens <220> <223> Genbank Accession No. U19495 <400> 16 gcacgggaca ggccgggcca cacccaccgg ggcgagctcg gagggcggcg ctctgggcgg 60 agggcccggc ggctcggccc agggcgcgtt acctcgtcgc cggggccgga gagggcgggc 120 ggaggcacgg ggcctggagg cgccaggcgg aggatgcggg cgacacggtg gcggcggcga 180 ccgcgcgacc gggcgggcgg gcgggcaggg gcgagcggag ggagggagcg gactgcggca 240 ggatctgtcg aggaaaaatc ttgcggccgg cgattccccg ccttttaagc gcagcctgca 300 ctccccccac cccacgcagg ggcgggcctt ccccaacgcg ggcgcccact ggccgccgcg 360 cgccgctccc ctccagctcg cctgcgcctc tcactctccg tcagccgcat tgcccgctcg 420 gcgtccggcc cccgacccgc gctcgtccgc ccgcccgccc gcccgcccgc gccatgaacg 480 ccaaggtcgt ggtcgtgctg gtcctcgtgc tgaccgcgct ctgcctcagc gacgggaagc 540 ccgtcagcct gagctacaga tgcccatgcc gattcttcga aagccatgtt gccagagcca 600 acgtcaagca tctcaaaatt ctcaacactc caaactgtgc ccttcagatt gtagcccggc 660 tgaagaacaa caacagacaa gtgtgcattg acccgaagct aaagtggatt caggagtacc 720 tggagaaagc tttaaacaag taagcacaac agccaaaaag gactttccgc tagacccact 780 cgaggaaaac taaaaccttg tgagagatga aagggcaaag acgtggggga gggggcctta 840 accatgagga ccaggtgtgt gtgtggggtg ggcacattga tctgggatcg ggcctgaggt 900 ttgccagcat ttagaccctg catttatagc atacggtatg atattgcagc ttatattcat 960 ccatgccctg tacctgtgca cgttggaatt tttattactg gggtttttct aagaaagaaa 1020 ttgtattatc aacagcattt tcaagcagtt agttccttca tgatcatcac aatcatcatc 1080 attctcattc tcatttttta aatcaacgag tacttcaaga tctgaatttg gcttgtttgg 1140 agcatctcct ctgctcccct ggggagtctg ggcacagtca ggtggtggct taacagggag 1200 ctggaaaaag tgtcctttct tcagacactg aggctcccgc agcagcgccc ctcccaagag 1260 gaaggcctct gtggcactca gataccgact ggggctgggc gccgccactg ccttcacctc 1320 ctctttcaac ctcagtgatt ggctctgtgg gctccatgta gaagccacta ttactgggac 1380 tgtgctcaga gacccctctc ccagctattc ctactctctc cccgactccg agagcatgca 1440 ttaatcttgc ttctgcttct catttctgta gcctgatcag cgccgcacca gccgggaaga 1500 gggtgattgc tggggctcgt gccctgcatc cctctcctcc cagggcctgc cccacagctc 1560 gggccctctg tgagatccgt ctttggcctc ctccagaatg gagctggccc tctcctgggg 1620 atgtgtaatg gtccccctgc ttacccgcaa aagacaagtc tttacagaat caaatgcaat 1680 tttaaatctg agagctcgct ttgagtgact gggttttgtg attgcctctg aagcctatgt 1740 atgccatgga ggcactaaca aactctgagg tttccgaaat cagaagcgaa aaaatcagtg 1800 aataaaccat catcttgcca ctaccccctc ctgaagccac agcagggttt caggttccaa 1860 tcagaactgt tggcaaggtg acatttccat gcataaatgc gatccacaga aggtcctggt 1920 ggtatttgta actttttgca aggcattttt ttatatatat ttttgtgcac attttttttt 1980 acgtttcttt agaaaacaaa tgtatttcaa aatatattta tagtcgaaca attcatatat 2040 ttgaagtgga gccatatgaa tgtcagtagt ttatacttct ctattatctc aaactactgg 2100 caatttgtaa agaaatatat atgatatata aatgtgattg cagcttttca atgttagcca 2160 cagtgtattt tttcacttgt actaaaattg tatcaaatgt gacattatat gcactagcaa 2220 taaaatgcta attgtttcat ggta 2244 <210> 17 <211> 1744 <212> DNA <213> Homo sapiens <220> <223> Genbank Accession No. M12625 <400> 17 tgaggcctga ctttttcaat aaaacattgt gtagttctgg gcctcctgct gccccggctc 60 tgtttcccct ggcgccaaga gaagaaggcg gaactgaacc caggcccaga gccggctccc 120 tgaggctgtg cccctttccg gcaatctctg gccacaaccc ccactggcca ggccgtccct 180 cccactggcc ctagggcccc tcccactccc acaccagata aggacagccc agtgccgctt 240 tctctggcag taggcaccag ggctggaatg gggccgcccg gctccccatg gcagtgggtg 300 acgctgctgc tggggctgct gctccctcct gccgccccct tctggctcct caatgtgctc 360 ttccccccgc acaccacgcc caaggctgag ctcagtaacc acacacggcc cgtcatcctc 420 gtgcccggct gcctggggaa tcagctagaa gccaagctgg acaaaccaga tgtggtgaac 480 tggatgtgct accgcaagac agaggacttc ttcaccatct ggctggatct caacatgttc 540 ctaccccttg gggtagactg ctggatcgat aacaccaggg ttgtctacaa ccggagctct 600 gggctcgtgt ccaacgcccc tggtgtccag atccgcgtcc ctggctttgg caagacctac 660 tctgtggagt acctggacag cagcaagctg gcagggtacc tgcacacact ggtgcagaac 720 ctggtcaaca atggctacgt gcgggacgag actgtgcgcg ccgcccccta tgactggcgg 780 ctggagcccg gccagcagga ggagtactac cgcaagctcg cagggctggt ggaggagatg 840 cacgctgcct atgggaagcc tgtcttcctc attggccaca gcctcggctg tctacacttg 900 ctctatttcc tgctgcgcca gccccaggcc tggaaggacc gctttattga tggcttcatc 960 tctcttgggg ctccctgggg tggctccatc aagcccatgc tggtcttggc ctcaggtgac 1020 aaccagggca tccccatcat gtccagcatc aagctgaaag aggagcagcg cataaccacc 1080 acctccccct ggatgtttcc ctctcgcatg gcgtggcctg aggaccacgt gttcatttcc 1140 acacccagct tcaactacac aggccgtgac ttccaacgct tctttgcaga cctgcacttt 1200 gaggaaggct ggtacatgtg gctgcagtca cgtgacctcc tggcaggact cccagcacct 1260 ggtgtggaag tatactgtct ttacggcgtg ggcctgccca cgccccgcac ctacatctac 1320 gaccacggct tcccctacac ggaccctgtg ggtgtgctct atgaggatgg tgatgacacg 1380 gtggcgaccc gcagcaccga gctctgtggc ctgtggcagg gccgccagcc acagcctgtg 1440 cacctgctgc ccctgcacgg gatacagcat ctcaacatgg tcttcagcaa cctgaccctg 1500 gagcacatca atgccatcct gctgggtgcc taccgccagg gtccccctgc atccccgact 1560 gccagcccag agcccccgcc tcctgaataa agaccttcct ttgctaccgt aagccctgat 1620 ggctatgttt caggttgaag ggaggcacta gagtcccaca ctaggtttca ctcctcacca 1680 gccacaggct cagtgctgtg tgcagtgagg caagatgggc tctgctgagg cctgggactg 1740 agct 1744 <210> 18 <211> 686 <212> DNA <213> Homo sapiens <220> <223> Genbank Accession No. AL042399 <220> <221> unsure <222> (1)..(686) <223> n = a or c or g or t <400> 18 gtgcctgtca tcttcgttgc tgcccacatg atgtcatctg gctgctcttg ggcagggctg 60 ggagccactt tggggttctg ggaagggcag gaggggctct gtggctctaa agcacctccc 120 tttaaccccc tttgtccatc cacagctctc ggccacttta accattccca tctggcagtg 180 gttcttgacc cggtttggca agaagacagc tgtatatgtt gggatctcag tgagtggggt 240 tgaagagcag agcctgggtt gagttgggat gtctggtggg aacctcccag ctgattcatc 300 ttcctgcacc cccttcccta gtcagcagtg ccatttctca tcttggtggc cctcatggag 360 agtaacctca tcattacata tgcggtagct gtggcagctg gcatcagtgt ggcagctgcc 420 ttcttactac cctggtccat gctgcctgat gtcattgacg acttccatct gaagcagccc 480 cacttccatg gaaccgagcc catcttcttc tccttctatg tcttcttcac caagtttgcc 540 tctggagtgt cactgggcat ttctaccctc agtctggact ttgcagggta ccagacccgt 600 ggctgctcgc agccggaacg tgtcaagttt acactgaaca tgctcgtgac catggcttnc 660 cataagttct catcctgctg ggcctc 686 <210> 19 <211> 364 <212> DNA <213> Homo sapiens <220> <223> Genbank Accession No. D63160 <400> 19 cctgcacagg agattccctg acgttccaca acaaccagtc cttctccacc aaagaccagg 60 acaatgatct taacaccgga aattgtgctg tgatgtttca gggagcttgg tggtacaaaa 120 actgccatgt gtcaaacctg aatggtcgct acctcagggg gactcatggc agctttgcaa 180 atggcatcaa ctggaagtcg gggaaaggat acaattatag ctacaaggtg tcagagatga 240 aggtgcgacc tgcctagccc aggccggcct cagggtcagg acgcctccac acatagttgg 300 ttggggggta gggtttggga gcttggccct acggtttgta aaagaaacac atgtcgtgat 360 tcta 364 <210> 20 <211> 1564 <212> DNA <213> Homo sapiens <220> <223> Genbank Accession No. D88587 <400> 20 cgggcaggcc cagccttgta gtctgcaaag accatgcaag ccttggttga taaaccggga 60 ttctactgga agtttgcact ttccccacat cagccaagat gggtaaactg ccttaacaca 120 aaagtcacat gccccacaaa atatttcctt ctatctcaaa acagtattag cttctttaat 180 ctaagaaggt aatgagaggt ttttaaaact gagttaagtc agcagttcag caagtgctta 240 cgaaagacag tcaaaatata ggcaagttac tttaaatggg tattatttgt ccttactttc 300 ccaatgtagg caagtgcctg tgatataaca atttagggaa taatgggaga ataaaaagca 360 tattagtttc aatcagattt cctggcatat atcacagacc ctaaggaatt acaaagacaa 420 aaaagcaagc tctttggttt ctgcatggtt ctttgcagac tacaaggctg cccctgcaag 480 cacttggatg aaaagaccgg gattctactg gaagtttgca ctttccccac atcagccaag 540 atggatctac tgtggatcct gccctccctg tggcttctcc tgcttggggg gcctgcctgc 600 ctgaagaccc aggaacaccc cagctgccca ggacccaggg aactggaagc cagcaaagtt 660 gtcctcctgc ccagttgtcc cggagctcca ggaagtcctg gggagaaggg agccccaggt 720 cctcaagggc cacctggacc accaggcaag atgggcccca agggtgagcc aggagatcca 780 gtgaacctgc tccggtgcca ggaaggcccc agaaactgcc gggagctgtt gagccagggc 840 gccaccttga gcggctggta ccatctgtgc ctacctgagg gcagggccct cccagtcttt 900 tgtgacatgg acaccgaggg gggcggctgg ctggtgtttc agaggcgcca ggatggttct 960 gtggatttct tccgctcttg gtcctcctac agagcaggtt ttgggaacca agagagtgaa 1020 ttctggctgg gaaatgagaa tttgcaccag cttactctcc agggtaactg ggagctgcgg 1080 gtagagctgg aagactttaa tggtaaccgt actttcgccc actatgcgac cttccgcctc 1140 ctcggtgagg tagaccacta ccagctggca ctgggcaagt tctcagaggg cactgcaggg 1200 gattccctga gcctccacag tgggaggccc tttaccacct atgacgctga ccacgattca 1260 agcaacagca actgtgcagt gattgtccac ggtgcctggt ggtatgcatc ctgttaccga 1320 tcaaatctca atggtcgcta tgcagtgtct gatgctgccg cccacaaata tggcattgac 1380 tgggcctcag gccgtggtgt gggccacccc taccgcaggg ttcggatgat gcttcgatag 1440 ggcactctgg cagccagtgc ccttatctct cctgtacagc ttccggatcg tcagccacct 1500 tgcctttgcc aaccacctct gcttgcctgt ccacatttaa aaataaaatc attttagccc 1560 tttc 1564 <210> 21 <211> 447 <212> DNA <213> Homo sapiens <220> <223> Genbank Accession No. AA224832 <220> <221> unsure <222> (1)..(438) <223> n = a or c or g or t <400> 21 agcaggccan catactacta ctaanttcgc ggccngtcng actctgtccc gctgcgtgtt 60 ctcctctcag atcggggact cctgcttctc cttgccanta aatggacccc aactgctcct 120 gctcgcctgt tggctcctgt gcctgtgccg gctcctgcaa atgcaaagag tgcaaatgca 180 cctcctgcaa gaagagctgc tgctcctgct gccctgtgng tgctgccaag tgtgcccagg 240 gctgcatctg caaagggacg tcagacaaag tgcagctgct gtgcctgatt gccaggacag 300 ctgtgctnct cagatgtaaa taagagcaac ctatataaac ctggattttt tttttttttt 360 ttttttgtac aaccctgacc cgtttggcaa atcttttttt ctatgaaata tgtgaatggg 420 caataaattc atctagacta aaaaaaa 447 <210> 22 <211> 567 <212> DNA <213> Homo sapiens <220> <223> Genbank Accession No. AI052592 <220> <221> unsure <222> (1)..(567) <223> n = a or c or g or t <400> 22 caggtttcta acatttaatc tccacttagg gaattggagg tcagaaatga ataaaatacc 60 atgccccagt aggctccagt ctagggaagt gggcagcagg cagaaaccaa gacacagaaa 120 gcaacgacac ataacagata tgctatgata caaatggtgc tgcaggagct gcacagttcg 180 gaggccattt ctggccagag gatgggatgc gtgaaatcca ggaaggcttc caggaaggag 240 tagctggcac tgggatgggc aggaacagca atgtctctac tgatggggtn ttttttncca 300 aaattttttt tttggagaaa gctggcaaag ttgagaagtt tggagactaa ccgtgacaaa 360 atttaaacat caggtatgtg aaggcaaggg ggaccaactg tgacaaaatg taaacgtcaa 420 gtgtgtgaag tcaaagggga accaggaaag taaaagagtg acaatcagca gtgcttttgg 480 caaaaaggcc tctggcagca gtgtagaaga gaaacgcaga gatcacaggt ataagaatga 540 cagtaggaga ggggaggagg gtacata 567 <210> 23 <211> 430 <212> DNA <213> Homo sapiens <220> <223> Genbank Accession No. AI937227 <400> 23 ttttttggaa atcaaaagaa ccagccattt tattccaaga ggggtgtttt ggggcagcag 60 gaataaataa ggaagggagg ggacgggggc agggcaggta ggttctacgt cttgcagcac 120 atcccacact ttgatcgatg acagcagccg cagcagaaaa tgcagatggg gaagtgggtg 180 tctcgcctcc ttcgcctctg gaacatgggc atccagctgg ccctggctcc agctctgtcc 240 tggggttgca gctctgcaag ttgtcccgtc tgttgtggga aaacagagcc actggtcagg 300 ctggcgagga ggaggaggag caggaggcaa gcggcccaga tctgggagct cagtgccatc 360 gtgccgtctg tctggctgtc ccactgctgg gtcttgagct tgctctggtg tctgggaccg 420 agtgacagtc 430 <210> 24 <211> 630 <212> DNA <213> Homo sapiens <220> <223> Genbank Accession No. AA167715 <220> <221> unsure <222> (1)..(630) <223> n = a or c or g or t <400> 24 tttttttttt tttttttttt tttttttttt tttttttaaa tttcaagaca actttatcca 60 gacaggcgcc tcncaaatag aacacaggga agttaggcag cagttactaa aatacagtcn 120 cgccaaatga tttacaacag aacacaacag gagcagggga tctgtgggtg gggctgggct 180 gggccnctat ctcacagggc ctgagtcaag ccagcccgcc ctgcaaggca gggctgacct 240 gcaagcggag atctcacttc ctcttacccc aaattcatac ctccattttc cccgccccca 300 tctctcccca gggtcctcaa gtgggaaagg gagaggtagc atccctcgga tccaggccca 360 ctccactccg tctccggcac cagtgggcag gctgagtctg ggcctcaagg ggcctgggct 420 tagggtatct atggcagtag gaaaatgaca tggacaggct cttcaggggt aggctaaagt 480 cctctggcca gcagtaccca gagaaaatgg gcagcagcag gtaaaccagc caggaggtgg 540 agtcctctga anccacagca gancccacct ctggccagcc ctgnccaaat tgggggtaag 600 acatgaaatc tggtaagaaa tggtgcctca 630 <210> 25 <211> 489 <212> DNA <213> Homo sapiens <220> <223> Genbank Accession No. AI424433 <400> 25 cctcttcctc ctcctcttct acttcaggct catctttcat tctcattaga gttggaggga 60 gttctggacg cttggggggt aacttcccta ctgttccagt ttttaatttg aatttgcttc 120 ctcctttcat ggcaccaaat agaggcaatg taagcttttt agctttgttt tctgcacctg 180 tagtctgagt ttcagtcttt tttagttctg gaatctctgc tggctttaca atttttatta 240 accctttaag tctctgttgt tctttcctca gttcaaaagt tctcaggtga agtttcttcc 300 gggacacacc atctaatgta ctgcctgatt tcatttctga catgaacgca tctaaagaat 360 cctgagatgg agactctgat agaacttggc ttgaggcttt caatctctca gaaatttcag 420 aaagttccct ctcagcatca tttaattttg caaccaatga ttcaaaggtc tctggcttct 480 catcaatct 489 <210> 26 <211> 6711 <212> DNA <213> Homo sapiens <220> <223> Genbank Accession No. X52851 <400> 26 gaattccctt gtaaggtttt cttaacaaaa caccagtcac ataagtgcat tttattttat 60 atttttgttt atttatttga gacggagtct cttgtctctc aggctggagt gcagtggcgc 120 catctctgct cgctgcaacc tccacctcct gggttccagc gattctcctg cctcagcctc 180 ccgagggggt agctgggact acaggtgcgc accaccatgc ccagctaatt ttgtattttt 240 cgtagagatg gggtttcacc atgttgtcca ggctggtctt gaactcctga cctcaggtga 300 tcctcccgcc tcggcctccc aaagtgctgg aattacaggc gtgatccacc gcacccggcc 360 tattttttga gagagggtca cactctgtcg tcccggctgg aatgcagtga tgcgatcacc 420 gcccactaca gcctcgacct ccgggctcaa gcaatcctcc ccgcccagcc tcctgagtag 480 cgagcgcctc gacgcccagc taatttttat ttttatttat ttttttgtag agacggcgtc 540 tctctaagat gcccaggctg gtggccggtg tcgaactcct aagatgaagc gatcctcccc 600 ggccttggcc tccgcgcctc ctaaagcgcc aggtatgagc caccgcgcct ggcctacaag 660 tgcattttaa ttaaagtatt attaatgtct ttgcctgaag aaattcgctt ttaaattgtg 720 acttatcttt cacccaaaaa tcaaagcaca attcagcccc gaggcggggg cggtaggagc 780 tgggcggggc gggggcaggg aaagaccagg agcagagatt caaaaagagt aagagggcaa 840 aatgtgcata atgcatcttc acaggtaaga gcctggccag gctcctgttt taatggcttc 900 ctcctgaaga agattcaagc agagtgtaag atattttcgg aaagtagagc attttgaaag 960 catttcataa tctctcaaaa ccggagactg ctcctgtccc acctcgttag agaaaacagc 1020 gatgctcaaa ggcaacctcc ttcctgacat tgcctggtag gacgcgacgt ggtgtttgcc 1080 cgcgcggaat gcggacgcaa ggctgctcct aggtctcggg gacgcgccat ccccatttcc 1140 gctcgcggag gcgtagggtc cgggcgcggg accccagtcg accttgactg gcggcgcgac 1200 cttgaggcct gcgttcgcct cagttgcccc ctctgtgcaa tggggagacg cgcctcatcg 1260 cttgacaacg gccgaagagc cgccgcgctt ccgtctcccg cgtgcgcgcg ccatgctgcc 1320 cacccccgtt ccgcactgac cctcccccgt gccccgcgtc ccgtactgcc gccccgcccc 1380 gagtcccatg ccgcagccac cgcgacggag cccgcaggcg ggaacctgcc tccgcgcgtt 1440 agcgcgcacg cgcgcctcat gtgtcgtccc catcagcgcc ggcttccgtc tataggccag 1500 atgcactgtc actctggcga agtcgcagac ccgattggcc gggacggagg cgcgagaccg 1560 ggttgcgggc ggggccgaac gtggtataaa acgggcggga ggccaggctc gtgccgtttt 1620 gcagacgcca ccgccgagga aaaccgtgta ctattagcca tggtcaaccc caccgtgttc 1680 ttcgacattg ccgtcgacgg cgagcccttg ggccgcgtct cctttgaggt cgggcgggcg 1740 gcggcgtgcg ggaatggggc ccagaaagtg ggccggggtc ggggtgggtg gtagcgcccc 1800 aaaggcccgg gcgcggggcg accctgcttg aggggcgagc gcgggcgggc tgcggcgcca 1860 tttcctgacg aggggccatt ttgggaggtc cgcgagtcgc gggaggaggc cgggacgcgg 1920 cggacaaagg caggcggggc ggctgcgagg ccgttggggg agggggcccg cgtccgcccg 1980 cccgcctcat gtggccgcgc cctgtcctgt ccgacgcacg tgctcggcgg ccgcgctcag 2040 gtccgcgcct tgagagtcgt tgtccgccct agcttggcct gggcgccgca gaccggagcc 2100 agaagcacgc tcgcgggggc ttgcgaccgc cttcctggga agctgtcccc tggcaggcat 2160 gggtgcttta catcctgagc tgggaagctg tttgcttgag ggtttttctc aaggatcgag 2220 gcgcggtgtg agcccgtcca tgctcggtcc tgtagatccc gggaggccat gttataaaag 2280 gagacttgct gggatgtgac gggttgccac ttgaaatatc ttccatttgg ataaagtagg 2340 aatatttata catgtgcccc aaacgtccct ccgtgtcccc cacccccaag cggaaatgtg 2400 aaaatgggcc ttgcctttgc tggtgcccaa ggaccgcctt ccactgcagt gacggcgctg 2460 gcgggggagg cgctcttgag cccctcccga ttgtccctct gcctagcaag caagttgcga 2520 ctggccacaa ggcaggcctc ttccgaccaa ggtggattac cagtgattac ctaattagtt 2580 ttgagagcgt taaatgagtt cttaaagatc agttgtaatt atagcatagt atctaaactt 2640 ggcgcgtgtc ttcaaagtta aatattgagt acgattccgt tccagttaac atggatagac 2700 cttagggagt agcgaaatag gatgttagtg gttttattcc tttaaatcac atctcaaaag 2760 gccaccaatg gctagtttgg atcttattcc gaaaatagat tgatcctcat gcagtcttcg 2820 tgaggacaga gcgatttcct tgttgcctac cctgtccata gtgcctggca cataggcact 2880 gaaacactgc atgttaatcc acaccccacc ccacctatga gtgtagtcaa agctggtaag 2940 tgacaagggc tttcgtggaa acttggcctg acctaatgtt gggcatcagg ttacccaaag 3000 agcttcaggg aaatgagaaa ggacttgcag gtcttgatga gaatggaggg gtaactgcca 3060 atgagggctt tggctttagc gaaagtctga aagggaagcc ataggaactt aaacgtaccg 3120 actataaagc tctgagaaaa gctgatgttt tagaaagacc atacattcta ggtacaaata 3180 cctaaaaact aaaaaataag tacgttggcc aggcgggcgg atcacgaagt caggagattg 3240 agaccatcct gggcccctgg tgaaacccca cctctattaa aaatacaaaa attagctggg 3300 cgtggtggcg cttgcctgta atctcagcta ctctagaggc tgaggcagga gatcgcttga 3360 accccggagg cggaggctgc agtgagccga gatcgtgcca ctgcactcca gcctggtgac 3420 agcgagactc ttgtctcaaa aaaaaaaaag tacattgcta taagagaagt gcacacggat 3480 actagtagtt aattcagtca catctgtgaa atagcttata aaatgctact tttaaacaag 3540 ctgtttttat gaaagggctt gtaaatgttt atggtattta agctacctct ctagccataa 3600 cgtattatac attcaagaaa ggttcaaaac cagatatact agaaaccaat ctttattttt 3660 taccccacta ctaggtaagg gcctggatac caagaagtga ctgctcatct aatccataaa 3720 gctatgttaa cagattggag gtagtagcat tttcattaca agtgactaaa agaacagctg 3780 tttacccctg atcgtgcagc agtgcttgct gttccttaga attttgcctt gtaagttcta 3840 gctcaagttg gggggtggtg atagacattt aagaagccat atatcttttc agaagtaggt 3900 gtgatgtact aaaagtttga gacactttct agaagtctca ctatttaagt tatgactagt 3960 attggatttt tggcatgtct ttgggtttca tgtttcttaa cccaactgcc tgcagggcct 4020 tatggctgtc aggagcagtt cttgggaatt aaagtaatta ctgaagaagt attctagtga 4080 gaaaatgaat ttatgactca gaagccccta aagacatggg tactaagcaa caaaataagc 4140 agatgttaat taactgtaat tttctcttac agctgtttgc agacaaggtc ccaaagacag 4200 caggttggtc cattttctaa gtttaacaaa gatgttccaa ttgtgacagt ttgtgtgtgt 4260 gtgtgtatat atatattttt atgtatgtat atatgtgttt aatttttttt taaacagaaa 4320 attttcgtgc tctgagcact ggagagaaag gatttggtta taagggttcc tgctttcaca 4380 gaattattcc agggtttatg tgtcaggtac gaaatttact gaattttatt ttatttgggt 4440 tgctcccttc atttgggatt gagccagaat atttcaggat acacatatct gaactgttac 4500 tctaccattt cggttctatt taacccttct attcagtttg aacttgggtt taaagtttga 4560 accttgcaga tttggcacac ttcatggtta tgttgtcaga agtgacattt ttcctatatg 4620 ttgacagggt ggtgacttca cacgccataa tggcactggt ggcaagtcca tctatgggga 4680 gaaatttgaa gatgagaact tcatcctaaa gcatacgggt cctggcatct tgtccatggc 4740 aaatgctgga cccaacacaa atggttccca gtttttcatc tgcactgcca agactgagtg 4800 gtaagggtac aacatggcac actaaccacc tgactaaatg aaaagttgcc ctggggggaa 4860 cggaacaaac actacttttc ttcaaccttt gcttccacag actttttcat ccctaagata 4920 ctagaagaag agcatacata aatgacaaat atagccaatg tgatacagaa tgtcagatac 4980 tatgatagaa acttggccct tagctgggtg gttgaattag gtgctacttt tttgagatgg 5040 agttttgctc tgttgccagg ttggagtgca gtggcacaat ctgggctcac tgcaacctct 5100 gcctcctggg ttcaagcgat tctcctgcct tggcctcctg agtagctgag aatacagatg 5160 tgtgccagca tgcctggcta attttttgta tttttgtgga gacggggttt catcatgttg 5220 gccaagctgg tcttgaactc gtgacttaag gtgaaccacc tgccttggcc ccccaaagtg 5280 ctgggatttc aggcatgagc cactgcgccc aaccaattaa gtgctttttt tttttttttt 5340 cttttctcag actggatctc gctcttatct cccaggttgg agtgcagtgg tgccatctca 5400 gctcactgca acctcctccc gggttcaagc aattcttctg cctcagcctc tcaagtagct 5460 ggaactacag gcatgcacca ccactcccag ctaaattgtg tattattagt agagcgggat 5520 ttaccatgtt gtccaggctg gtctcgaact cctgggctca agtgatctgc ctgccttgac 5580 ccccccgaag tgctgggatt acaggcatga gccactgtgc ccacccaatt aagtgctgct 5640 tttatgttac tattaataac atgcggttgg ttgggttttt tgtttctttg gggtttttgt 5700 tttgttttgt ttgtttttgg gggagggggg cgcaattcat tctatatgtg taactctttt 5760 ttgagatgga gtttcgctct gtcgcccagg ctggagtgca gtggcgcgat ctcggctcac 5820 tgcaagctcc gcctcccagg ttcacgccat tctcctgcct cagcctcccg agtagctggg 5880 actataggca catgccacca tgcccggcta attttttgta tttttagtag agacagggtt 5940 tcaccgtgtt agccaggatg gtctcgatct cctgacctcg tgatccgccc gccttggcct 6000 cccaaagtgc tgggattaca ggcgtgagcc accgcacccg gcctatatgt gtaactcttt 6060 aatggtaatt ggagaatcat gtttaatgac atttagtaca aaaggcttca gttaaaaaaa 6120 aaaaaaaaaa gctacctttc tcgtcttggt tcatgacaca tggaggctgc ttgtttgtgg 6180 ttgccagtca taatgattgt tcttcctttt caaggttgga tggcaagcat gtggtgtttg 6240 gcaaagtgaa agaaggcatg aatattgtgg aggccatgga gcgctttggg tccaggaatg 6300 gcaagaccag caagaagatc accattgctg actgtggaca actcgaataa gtttgacttg 6360 tgttttatct taaccaccag atcattcctt ctgtagctca ggagagcacc cctccacccc 6420 atttgctcgc agtatcctag aatctttgtg ctctcgctgc agttcccttt gggttccatg 6480 ttttccttgt tccctcccat gcctagctgg attgcagagt taagtttatg attatgaaat 6540 aaaaactaaa taacaattgt cctcgtttga gttaagtgtt gatgtaggct ttattttaag 6600 cagtaatggg ttacttctga aacatcactt gtttgcttaa ttctacacag tacttagatt 6660 ttttttactt tccagtccca ggaagtgtca atgtttgttg agtggaatat t 6711 <210> 27 <211> 542 <212> DNA <213> Homo sapiens <220> <223> Genbank Accession No. AF072812 <400> 27 ggttgtgcgc gcaaagccgc gcggggctga gggtcttgtt ctgccggcgc ctgtccggac 60 ccgggcccct ctccgctttc ggccggcctc gggcaccggg cttctggagc tcccggagcc 120 ctgcctgttc cctgtccatc caggccagca gctgaaggag cctcacctgc ctcccttctc 180 tgagtagcac ggatttgagg agaagcagcg aagatgtcca gcgagcctcc ccctccttat 240 cctgggggcc ccacagcccc acttctggaa gagaaaagtg gagccccgcc caccccaggc 300 cgttcctccc cagctgtgat gcagccccct ccaggcatgc cactgccccc tgcggacatt 360 ggccccccac cctatgagcc gccgggtcac ccaatgcccc agcctggctt catcccacca 420 cacatgagtg cagatggcac ctacatgcct ccgggtttct accctcctcc aggcccccac 480 ccacccatgg gctactaccc cccagggccc tacacgccag ggccctaccc tggccctggg 540 gg 542 <210> 28 <211> 2478 <212> DNA <213> Homo sapiens <220> <223> Genbank Accession No. AF006043 <400> 28 cacctttccg cgggccgcgg ggatggcggc gcagggcgta gggcctgggc cggggtcggc 60 ggcgcccccg gggctggagg cggcccggca gaagctggcg ctgcggcgga agaaggtgct 120 gagcaccgaa ggagatggag ctgtacgagc tggcgcaggc ggcgggcggc gctatcgacc 180 ccgacgtgtt caagatcctg gtggacctgc tgaagctgaa cgtggccccc ctcgccgtct 240 tccagatgct caagtccatg tgtgccgggc agaggctagc gagcgagccc caggaccctg 300 cggccgtgtc tctgcccacg tcgagcgtgc ccgagacccg agggagaaac aaaggcagcg 360 ctgccctcgg gggagcattg gccctggcgg aacgcagcag ccgcgaagga tccagccaga 420 ggatgccacg ccagcccagc gctaccaggc tgcccaaggg gggcgggcct gggaagagcc 480 ctacacgggg cagcacctag gatggggcag agacttgttg catctttgtc cccagcaaag 540 gctacatgtt acctccttca attgataata aacctttctg agatgcaaac tcgagaatac 600 tgcccagtta ctctagcgcg ccaggccgaa ccgcagcttc ttggcttagg tacttctact 660 cacagcggcc gattccgagg ccaactccag caatggcttt tgcaaatctg cggaaagtgc 720 tcatcagtga cagcctggac ccttgctgcc ggaagatctt gcaagaggga gggctgcagg 780 tggtggaaaa gcagaacctt agcaaagagg agctgatagc ggagctgcag gactgtgaag 840 gccttattgt tcgctctgcc accaaggtga ccgctgatgt catcaacgca gctgagaaac 900 tccaggtggt gggcagggct ggcacaggtg tggacaatgt ggatctggag gccgcaacaa 960 ggaagggcat cttggttatg aacaccccca atgggaacag cctcagtgcc gcagaactca 1020 cttgtggaat gatcatgtgc ctggccaggc agattcccca ggcgacggct tcgatgaagg 1080 acggcaaatg ggagcggaag aagttcatgg gaacagagct gaatggaaag accctgggaa 1140 ttcttggcct gggcaggatt gggagagagg tagctacccg gatgcagtcc tttgggatga 1200 agactatagg gtatgacccc atcatttccc cagaggtctc ggcctccttt ggtgttcagc 1260 agctgcccct ggaggagatc tggcctctct gtgatttcat cactgtgcac actcctctcc 1320 tgccctccac gacaggcttg ctgaatgaca acacctttgc ccagtgcaag aagggggtgc 1380 gtgtggtgaa ctgtgcccgt ggagggatcg tggacgaagg cgccctgctc cgggccctgc 1440 agtctggcca gtgtgccggg gctgcactgg acgtgtttac ggaagagccg ccacgggacc 1500 gggccttggt ggaccatgag aatgtcatca gctgtcccca cctgggtgcc agcaccaagg 1560 aggctcagag ccgctgtggg gaggaaattg ctgttcagtt cgtggacatg gtgaagggga 1620 aatctctcac gggggttgtg aatgcccagg cccttaccag tgccttctct ccacacacca 1680 agccttggat tggtctggca gaagctctgg ggacactgat gcgagcctgg gctgggtccc 1740 ccaaagggac catccaggtg ataacacagg gaacatccct gaagaatgct gggaactgcc 1800 taagccccgc agtcattgtc ggcctcctga aagaggcttc caagcaggcg gatgtgaact 1860 tggtgaacgc taagctgctg gtgaaagagg ctggcctcaa tgtcaccacc tcccacagcc 1920 ctgctgcacc aggggagcaa ggcttcgggg aatgcctcct ggccgtggcc ctggcaggcg 1980 ccccttacca ggctgtgggc ttggtccaag gcactacacc tgtactgcag gggctcaatg 2040 gagctgtctt caggccagaa gtgcctctcc gcagggacct gcccctgctc ctattccgga 2100 ctcagacctc tgaccctgca atgctgccta ccatgattgg cctcctggca gaggcaggcg 2160 tgcggctgct gtcctaccag acttcactgg tgtcagatgg ggagacctgg cacgtcatgg 2220 gcatctcctc cttgctgccc agcctggaag cgtggaagca gcatgtgact gaagccttcc 2280 agttccactt ctaaccttgg agctcactgg tccctgcctc tggggctttt ctgaagaaac 2340 ccacccactg tgatcaatag ggagagaaaa tccacattct tgggctgaac gcgggcctct 2400 gacactgctt acactgcact ctgaccctgt agtacagcaa taaccgtcta ataaagagcc 2460 tacccccaaa aaaaaaaa 2478 <210> 29 <211> 1524 <212> DNA <213> Homo sapiens <220> <223> Genbank Accession No. Y11215 <400> 29 gtcgccttcc agcccgtccg cctcccgacc agggcccgcg ccccgtcccg cctctctccc 60 gcccagccaa atgcaggccg ccgccctccc tgaggagatc cgttggctcc tggaagatgc 120 tgaagagttt ctggcagaag gtttgcggaa tgagaacctc agcgctgttg caagggatca 180 cagagaccat attctacggg gctttcagca aatcaaagcc aggtactatt gggattttca 240 gccccaaggg ggagacattg gacaggacag ctctgatgat aatcacagcg ggactcttgg 300 cctgtccctc acatccgatg cacccttttt gtcagattat caggatgagg gaatggaaga 360 catcgtaaaa ggagctcaag aacttgataa cgtaatcaag caaggatact tggagaagaa 420 aagcaaagat catagtttct ttggatcgga gtggcagaag cgatggtgtg ttgtcagcag 480 aggtctcttc tactactatg ctaatgagaa gagcaagcag cccaaaggga ccttcctcat 540 taagggctac agtgtacgga tggcccccca cctgcgaaga gattccaaga aagaatcctg 600 ctttgaactg acctcccagg ataggcgcac gtatgagttt acagctacta gtccagcaga 660 agccagagac tgggtggatc aaataagttt cttgttaaag gatctgagct ccttaaccat 720 tccatatgaa gaggatgagg aggaagaaga aaaagaagag acatatgatg atattgatgg 780 ttttgactcc ccaagttgtg gttcccagtg cagacccact atcttgcctg ggagtgtggg 840 gataaaagag cctacagagg agaaagaaga agaagatatt tatgaagtct tgccagatga 900 agagcatgat ctagaagagg atgagagtgg cactcgacga aaaggagtag actatgccag 960 ttactaccag ggcctatggg attgccatgg tgaccagcca gatgaactgt ccttccaacg 1020 gggtgacctc atccgtattc tgagcaagga gtataacatg tatggctggt gggtgggaga 1080 actgaacagc ctcgttggga ttgttccaaa ggagtatctc accactgcct ttgaagtgga 1140 agaaagatga aacccaggaa atatattctt ccctctctcc tcctttatga ggaaactgat 1200 catcaaaagt tcccactccc tacttctgca cccaccaacg cctgactcct ctctttgctg 1260 aagagaccca agtctcttga cacctcagag tgactgtaag ctaccagtaa gacaagtggg 1320 aagaggcacg ttcatcaaac ctgttactaa accagcctag tcatagctca tccccatgtg 1380 taaatgtgtc cacacaacca catctgcctt ttccacaagc ttttcacaaa gaaggtgaga 1440 gagaaggaaa ccttgggagg aggacattac tggttgttct ggctggtttg aaaagcacaa 1500 ataaacttgg gatgtggttc cttg 1524 <210> 30 <211> 19798 <212> DNA <213> Homo sapiens <220> <223> Genbank Accession No. AB014460 <400> 30 gatctcaatt cttttcttac tgaaccatcc ttgcgatgta ctcgtcgagg taacagctat 60 tgaatttgac caagttcacc agcaccagaa ggaattccga ggacaagcca acatccatcc 120 actgcaggac aaagtcagct aggggagaag cggcggcagt ttgcgaggac gccgaatcta 180 catctcccac tcacctcccc ctccccccgc aggacagtgt gtccaaaccc gtcactgcca 240 gaaaccccat catcagtccc ccggcagcaa cagacagacc acgcactggg cccgaagagg 300 ctcaggggag cccagggcag gccggctacg cacggacact aggatctacc gcccctgggg 360 ctgcacagag ggtctgtgcc gaggcggcag cagaagtgtg tatgccgtac actcagggcc 420 caacccgagg ctgggagacg ccgacatcac cagactcctg ggcgttcccc acccccagca 480 gagagcggct cggaggagac gtgtgcacac ttggctgccg gccacgtcac ctcagacagg 540 aaacctgacg gtaggcacct ggccggcacc tgtcctgcag gcagcccagc cactgaggcc 600 cttttctggg cgacagaaca gcaaagccag agtcagaccg atctcttcct cctctttctc 660 tacttcccag aatcatgaca cagagaccca agactaatgg aaacctccca ccacaggatg 720 gcaggaggaa ggtccacaaa gtggagaaag gaggaggaag acgggaccag tacgctccgg 780 ttgagaccaa gtcagcagca ccacctccca gtgacagaac tcgcccagct cctgccgttg 840 cagaggtgtt cggaggcccc aagccccaga gactcacagt cagcaggtct ggggtgaagg 900 ccaggactct gcatttttaa cacgtgcctc aggggcactc cggccacgca ggtgagccca 960 ggtgcatgaa gcagggtggg catacccgct gcaggccatc cctgagaacg gcagcccctc 1020 cccagcccca ggtccttccc atccaggtta cacttgatcg tcaaggccag agaaacctcc 1080 aacccaaggt ggcacccacc cagctcttcc tccaagtagg tgatgtgtct cccattgtct 1140 gtgagggcct tgaaaacctc cagcctttcg tgaaggtctt cgttggaagg gtaatccttg 1200 atgaccttaa agaagagggc tctgaggacc cccaaacgct cgccctaaag acaaaagcca 1260 caggatcagc agagcctgcc agcgtcgccc acacggctgc caagaagtcc ctgaagtgca 1320 ggggcacccg gactccagcc ctggacccct ctccttccca cagaggcgcc ctgcaagaga 1380 caggtctgca gcatcagcat tgtacagggc agggggccgg atgcaccggc cgaccgcaga 1440 gcggcgtatg gggagcaact ggtgtgtgtc gggacctggc acagcgggtg gcgcagagca 1500 ggggatgaca cagttcatgc ccgacccctg caatcggtgc agggcagaca gcgttgtgat 1560 cagagagtga ggacaaggcc tgagtggggg aaacccagga gagcctgtga gagtggacgg 1620 cccttctgag cagctgggac atgaaggagt agaagtggcc gaccagggga ggcaggaaca 1680 ccaagaggcc tgggtgttca gggtcagcca agaccagcac agatggaatg cagtgagcag 1740 gggagtggcc ccgaaagggt gcaagggcaa aacaacaccg tagccccaca ccagctgcca 1800 ggtacgatct cagcactctg cgacaactgc ctcatatgat ccccagaaca tcccataaga 1860 ggaaggtgca gtgaccatct gtttacaggc gaggaggcag tgcctacggt cacacagacc 1920 tcatgacacc aggagacccc acaggccatc cagctccaga gcccatcagc ccctagaccc 1980 tgtgcccagc aactcaccga ggcaggagtc caaacacggc ccagcaggga caggacagtc 2040 agtgggcagc ctgacgtcac ccatcccagc gtcgccctgg gccttacctg cccctgcacg 2100 atggccttca gcagagccag caccgcgtgc cgggcctcca gcggccgctc cggctgcaac 2160 agatccgcga ccgccttcca gagtgcttcc actgcgtgct gtcaccagca gaggggacag 2220 cggtgaggat gtgctctcca agaaccctgg ccccggcaac tggagcagtg ccgtgagcgg 2280 aggacaggga ggaacaacgg gggcttgtga ctgagagccc cacctccaaa gctcgtatct 2340 cctgtgtctc ctgcagcctg agatgaccac aggcttcgta cagggaacgg ctcagagctt 2400 cctcaaaccc cagcaggtcc ctttaactcc caccaggtga cagactgggg gctgagagga 2460 cagcagcaag ccagggcagc aatggtggcc tcacctggac caggagggag tcccactaga 2520 gctgccggaa tgctggcagg aagtcatggg acagtctcag aaccacaagt gcacactaag 2580 ccctaggcct gcacctgacc cagaatccct gcttgtggct ctcctctagt gaacacacca 2640 gcatcgggcc ctcgacccca tgcccctgcc cgacctctgc tgcctgcctg acctgctgag 2700 aaagagcgct gcgtggcctt ctgaaatctg cctcctctaa ctaccaccca gcctgtgagg 2760 ggctcatccc tgctccctaa agctgccaga atcagtctca ctcggcaggg gtttgggctg 2820 gctctcacca ccttcccttc tccacattaa ccaacagcca cggctttcag accacaggct 2880 cattcctggc cttactcctc taaggagggg aactaaaatg gccgtgttcc ggccaagtgc 2940 ggtggctcac acctgtaatc tcagcacttc gggtggcaga ggggagaggg tcacgtcagc 3000 ccaggagttt cagactagcc tgggcaacac agtgagaccc tgtcacgaca aaaaatacaa 3060 aacttagcca ggcgtggtgc tgcatgcctg tagtcccagc tacttgagag gctaaagtag 3120 gaggatcacg tgagcctggc aggttgaggc tgtagtgagc catgattgtg acactgcacc 3180 ccggcctggg tgacagagtg agaccttgtc tctaaccaaa taataacaaa atggccgtgt 3240 tcttttagat gtcatctgac caacatccca accactggca ctctcacctc ctttgtctca 3300 ttgacaatac tctttttttt tttttttttt tttttttttt ttgagacgga gtctcgctct 3360 gtcgcccagg ccggactgcg gactgcagtg gcgcaatctc ggctcactgc aagctccgct 3420 tcccgggttc acgccattct cctgcctcag cctccccagt agctgggact acaggcgccc 3480 gccaccgcgc ccggctaatt ttttgtattt ttagtagaga cggggtttca ccttgttagc 3540 caggatggtc tcgatctcct gacctcatga tccacccgcc tcggcctccc aaagtgctgg 3600 gattacaggc gtgagccacc gcgcccggcc ctcattgaca atactcttac cgttgcaacc 3660 tgagctgcaa agatccgtgg acacagggcc cgggaccatc ccagcctcgg aggcctattt 3720 atccactcac aggctgcccc gtacccacac aaacaacttt cagaacagga tgcaggacgc 3780 ttgttctttt ttttgttttc tgagacagtc ttgctctgtt gcccaggctg cagtgcaatg 3840 gcacaatctc agctcaccac aacctctgcc tcctgagttt aagcgattct cctccctcag 3900 cctcccaagt agctgggatt acaggtgccc gacaccatgc ccagctaatt tttgtatctt 3960 tagtagaaac agggttttgc cacattggcc aggcgggtct cgaactcctc acctcaggtg 4020 atccatccac cttggcctcc caaagtgctg ggattacagg cgtgaaccac tgcgcccggc 4080 taaggacacc tgttctttac acctatcttt ggtagtgtac ggccagcacg tttcagatga 4140 gctgctgcag aggtagcaat cactctcctc ttagcagatc tgagcatgag aggtccaggt 4200 ctcactgctc tcccacacac aaatgctggg caaggcaagg gcagagccct caggtgctct 4260 accagcaacc tgcactccca aaatgaccac ttcctgtcct gtccacaagt catcagggaa 4320 agtctggcaa tgtttgccca aaataaatat ttctatgtcc gtgaggtcgc ccaataccac 4380 cgaccagtca ccctcccaaa atggcaccaa gaccagcgtg cctaggattg ttctctgtgg 4440 aacaaaccct ttcttgattt ttcttggcct gaacttgtaa caggagagag cgagtgagca 4500 tgcgtttcta tcagccacta caaactcttc cttttttttt tttttgagac agagtcttgc 4560 tccgtcaccc agactggagt gcagtggggc gatctcggct cactgcaacc tgtgcctccc 4620 gggttcaagc gattctcctg cctcagcctc ccaagtagct gggattacag gcatgtgcca 4680 ccatgcccgg ctcatcatct tttagtacag acggggtttc gccatgttgg ccagagtggt 4740 cttgaactcc tgacctcgtg atccacccac ctcggcctcc caaagtccta ggattacagg 4800 cataagcccc cgcacccccg ctcggcatag aaatcctttc tggtgttgct agaaaagcct 4860 aatccctttg ctccccattt ccacgcttga ttggtccctc aaggttgtat tcggggcatt 4920 tccagtagct tccccatcac tacgatgaaa gctaaattcc cctaaaacag tgcaaactgg 4980 ctgggcgcag tggctcacgc ctgtaatccc agcactttgg gaggctgagg catatggttc 5040 acgaggtcag gagttcaaga ccagcctggc caacatggcg aaaccccgtc tctactaaaa 5100 atacaaaaag ccgggtgtgg tggcgcgtgc ctgtaatccc agctactcag gaggctgagg 5160 caggagaact gcttgaaccc aggaggcaga ggctgcagtg agccaagatt gtgccagcct 5220 gggcgacaga gcaagactcc atctcaaaaa aaaaaaaaaa aaaaagtgca aaccagatca 5280 tcggcagtca gctgtcaacc atgttcctaa aaaaagcaaa ctcaggctct gaatagtcta 5340 cgtgcctctc tctagtagct caactggata aacctacctc ttcaaatttc ttggtttttg 5400 cgacttcaca aatctgccct atcatccgga tgcgattgtt gaggccacat tccatgctca 5460 gttcctggag agagatgaaa gaagaaaaag gggccagtgc tcaggccacg gtctccttaa 5520 ctgcaagtca caaaccacct aaagactccc actgcatttt ccagactaga gacttaaaac 5580 agatctttct ggaatcaaga ttcacttgac gagccgcggt ggctcaggcc tgtaatccct 5640 gcactttggg gggccaaggc aggtggatca ccagaggtca ggagtttgag accagcctgc 5700 ccaacatgat gaaaccctgt ctctactaaa aatacaaaaa atttgctggg cgtggtggtg 5760 ggcgtctata atcccagcta ctcgggagag tgaggcagga gaatcccttg aacccaggag 5820 gcggagattg cagtgagccg agatcgcgcc cctgcgctcc agcctgggtg acaagagcga 5880 aactcggtct caaaaaaaaa aaaaaaaaaa gatttactga ggggctttac tgctccatcc 5940 cgaggagttg agaatgtgca attttttttc acaactgcaa atgttgtatt gagataaaac 6000 ataacatgaa atacaatttc aaactgcaca attttttttt agacggagtt ttgctcttct 6060 tccccaggat ggagtgcagt ggcgcgatca cggctcactg aaacctccgc ctcccgggtt 6120 caagcaattc tcgtctcagc cccccgagta gctggaatta caggcgccca ccactatgac 6180 cggctaattt ttggtatttt tagtagagac ggggtttcgc catgttggcc aggctggtct 6240 caaactcctg acctcaggtg atccacccgc ctcggcctcc caaagtgctg ggatgacagg 6300 cgtgagccac cgcacccagc caggatggac tatattttat tcatcagttg atgaacgttt 6360 tagttgtttc taagtagaaa actttacaag tgcaaaaatt cagcatttac tcatgggcaa 6420 aacacaatgc caggcatgtg tgacaaagac acaaacacac ataaaagata acgacctagc 6480 ccatgtgcga tggctcatgc ctgtaatccc agcactttgg gaggccaaag cgggcagatc 6540 acctgaggtc agcagttcaa gaccagcctg gccaagatag tgaaactcca tctctactaa 6600 aaatacaaaa attaaatggg tgtggtggca cgtgtctgta gtcccagcta ctcaggaggc 6660 tgaggcagga gaaccacttg aaactgggag gcagaggtag cagcgagcag agattgtgcc 6720 actgcactcc agcctaggca acagagcaag actcagtctc aaaaaaaaaa taaaataaag 6780 aacctacttc tcccaggaac tcacatctta tcatgtaaca cctggacata tccttacctg 6840 tgaagatgat gatactcagg cctcatctat aagatgggct ttctttcatc aacatctgaa 6900 tagtaactca agtgtgcctg aaccaggtca ccaagatcct gactttcgaa gtctcctgag 6960 gaaggacatg tcggcctcca agtactggag acagcattcc tgtgtagaca gttgccagca 7020 acccgtctcc cacagaacct ggtgcaagac caaacccagc cttctctgca tttccctcta 7080 gcctagcaaa gacacaggta gctcactcac tctcagtatt tccgcggtga tgataaactc 7140 cgtctgttta ccctctgcag acctgggatt tggcctcggt gttcccagtc ccaacagaat 7200 cttaaacttc tccttcaagc ctgaatcttt gcttgttggt ttggccatgg tggaccagga 7260 cgcaccagaa aacccctctg tgcaaacgaa acaggaatgg ggacatctga gcaacacctc 7320 tgcccacctt ccccactgcg gacctccagc cgtcaggacc ctgggtctct ggtgggcata 7380 acctttcctc ccacactccc tgggagaact caactacagc ccagctgacc agctcgcaaa 7440 caggcaccta ggaaagcccg ggagacacca ggcctggtct agagagctct ctactcagac 7500 gctgccgccc gccccgcccg actcagtgca cgggttagga ctgccgccgc gaagtcctgg 7560 gagccccgac gtttgccgtc tctcctctac ccatgtgaag caggagctgt cacggagccg 7620 cctgcagcag agacccgttc gcacccgcca tgacttaaaa ctaagggatg ctcggagctc 7680 cggagtcggg ttgcagtggg cgcgggtgag ggcccgggac ccggacactg cggggtccgc 7740 ctctctaggc cgctgccccg tggggaccgc cacttgcccc gtggggaccg ccacttaccc 7800 cgcgccgcgc caccgcgctc cgggccgccc cgacgcggag aaaggcgcac ccccctggcc 7860 ccgggacgcc gccggaagcg cgacccgcac ttccggtagc ggcattgcgc ggagggccgc 7920 cttgggagct tgctgggagt tgtagttctg tgccgccctc tggcggaaag gccggcgatc 7980 cttgcatcac gtgacggggc cgcatgggcc gccgggatgt gtagtccgca ggagtccggc 8040 atgaccgcct tgagcgcgag gatgctgacc cggagccgga gcctgggacc cggggctggg 8100 ccgcgggggt gtagggagga gcccgggcct ctccggagaa gagaggctgc agcaggtagc 8160 gccgcgccgt ggctggagcg tgggaggagg cgggataggg gctgcaggct ggagtcccgg 8220 gccgcctcct gcggctccca gctgcgcggg caggggctgc aaacccggca gccgcgaacg 8280 gttcccacgt gcggccctgc gttcccacct tgcgcctttt tcccaaagat tgcggtccgc 8340 aggggctggg tttcgggcgc tccgctccgc tgcccccttt cgccccaagc aagaaaacgc 8400 ttcctttccc accactctgt ccgggactct ccactccagg ctctgtgggt cccatccccg 8460 ccctcctgca gtgaacttgc tgtcctcgga gaggctgggt gccaaggaca cacgcagcca 8520 gaagcctgct cccccagctc gggggagggt gcctctgagg gaaaacagga aagggcatgg 8580 cacttattat atttatcctg cagccgttga ggacctgctg ggggccaagc actgcagtga 8640 gcagtgaggg acacggacag ggcctctgcg ctagtcccgc tgggacttct gcagaattgg 8700 ccaaagttgg attcccatag gcacccaggg accccagggg tagtccaaac tatggcagga 8760 ggaactggtg cagctgggag caggcaggtg gtgatgccag ccagggtggc aggagctttg 8820 atgccaggat agagtttgga gtttattatg acagtaaacg gaagtcaatt aggaggtttt 8880 gttgtttgtt ttgagatcgg gtcttgctct gtcacccagg ctgtagtgga gtgttgtgat 8940 ctcagctcac tgcaacctcc gccccccagg ttcaagcagt tctcctgcct cagcctccca 9000 agtagctgag actataggcc cctgccacca cacccggcta acttttgtat ttttagtaga 9060 gatggggttt tgccatattg gccaggctgg tcttgaactc ctgacctcaa gtgatccacc 9120 cacctcggcc tcccaaagtg ctgggattac aggcttgatc caccgcgccc ggccggccag 9180 gattttttaa aagggagtga cacaacctga tgtgggtgtt agcagactgt ctctggtgca 9240 gtatagaaga tgtattgggg gcaccttggt acaggctgtt gctagagtcc tcatgagcta 9300 acatggacct tgtcagggtc gctggcataa ggagggccca cataccccag actgcagagg 9360 gcagagcacc ccaagtgtat tagatgatgg acagttgtgg catgaacgag tgaggggtga 9420 gctagcaggc gggatggcac ccctacccta ccttcacctg tggccccacc agagggactg 9480 cgtggtgctt tttgcagaag cgaggaaaag ccacagcccc gtgaagcgtc cgcggaaagc 9540 acagagactg cgtgtggcct atgagggctc ggacagtgag aaaggtgagg gggctgagcc 9600 cctcaaggtg ccagtctggg agccccagga ctggcagcaa cagctggtca acatccgtgc 9660 catgaggaac aaaaaggatg cacctgtgga ccatctgggg actgagcact gctatgactc 9720 cagtgccccc ccaaaggtag gcaggggccc catctgccca aatgaccccc catcttagca 9780 aggtccttgt tttctttcta cccggtggct tttggctggc accctcccct gcagacagca 9840 ccttgggagg atggacaccc ggtgccccag agcatcgcct gcatcactgt agccactcag 9900 caggtcagga caccagtggt ttagggcctc gtgctcgaac ttctgcccag tgcaggcgtg 9960 acctgggctt tgtgtgatat caggaaggaa gagttccttt tgcttcacgg tcccagggcc 10020 tgaaaccctt agaccaagct gagttctaat ccctattctg ctaccaggtg gcttggatac 10080 aggcctctct gagcctcagt ttgcttgtct gtaaaatggg tagtatgggc caggcatggt 10140 ggttcaggcc tgtaatccca gcacttcggg aggccaaggc gggtggatca cctgaggtca 10200 ggagttcgag accagcctgg ccaatgtggc gaaaccacgt ctctactaaa aatacaaaaa 10260 ttagccaggt gtggtggcag gcacctgtaa ccccagctac ttaggagggc gaggcaggaa 10320 aatcgcttga accccggagg cggaggttgc agtgagccaa gatggcacca ccacacttca 10380 gcctgggtga aagagtgata ctgcatctca aaaaaaaaaa tttgttttaa acgggtagtg 10440 tgatgattca cgaagcaatc ataatagtag tggccaatgg ctgttcagta gtgatgggcc 10500 agatacgatc gtgttgggtt tttttttgag accaagtctt gctcttgttg cccaggctgg 10560 agtgcagtgg tgaaatctta gctcactgca accttcgcct ccgaggttca aattattctc 10620 ctgcctcggc ctcccgagta gctgggatta caggcatgca ccaccgcacc cagctaatgt 10680 ttgtattttt agtagagacg gggtttcacc acgttgatca ggctggtctc aaactcctga 10740 cttcaggtga tccgcctgcc ttggcctccc gaagtgctgg gatgacgggt gcgagccacc 10800 gcgcccggcc acatacgatt ctaagcactg agataattca tttaagcttc acattactcc 10860 agtgagtcag gtactattat tgtcctggtg ttgtagatga ccaaacatac ccaaaccaga 10920 cctccccacc ccacaggggg aggctgatgc ctcaagtgtg gcccagggca acaaaccagg 10980 gtgtgtcgag ggcggggggc ggagcctggc cagggaatca cccaggaccc gccgccaccc 11040 cggtccctgt cactgcacaa gcaggtacgc aggtaccagg tgctgctgtc actgatgctc 11100 tccagccaaa ccaaagacca ggtgacggcg ggcgccatgc agcgactgcg ggcgcggggc 11160 ctgacggtgg acagcatcct gcagacagat gatgccacgc tgggcaagct catctacccc 11220 gtcggtttct ggagggtgag ccctgcctgt ggcaacgggg gccgggtggc agtggcctga 11280 gagagacctc agaaggctga ggggggtggc gacggtgcag gaagtgaggg tcaagcatct 11340 caggctcggg gggtccccct gaagcccccc ccaggccgtg gggccctgag gcctgacgcc 11400 cagtcccagc agctccttgg ccttcctgtt cgcatcctcc cttccttcct ctgcttcccc 11460 gcctcgccgc ctgcccaccc ttcctcaccg ccaaggctgc ctgcccaccc gcctttccct 11520 ttgtttactg ctagcctctc ccggtgtgtc accccctcct gtccagagcc cctcaccctc 11580 caggagccct ggggaggctg ctccccaacc ccgccgagca ctggatggtg gtgggcggat 11640 ctgttgaaag cagcttggtg ggtggggccg cttccccttg gcacccgcgt gggccgcagt 11700 ttctcagatg ggttttaaat agccctctcc actcaggcac aggatgggaa ccacccggca 11760 ggcctggcag ctggtgggga agccccagct ccagccctcc ttcctgaagg cgcaggtgca 11820 gccaagcccc actcctggga gcggctggcc tgcttggcct ggcctgggtg ctggcaggga 11880 atgacgggca ggggaacccc agccagagcc tacacgtgca tcattggccc acacgggtgg 11940 gaggaggggg tcaggcctac cttgggcctc cctgctgccc tccgcttgtt cccgcctcct 12000 ggggggcggg ggctgagctt gcacacgtcc tcagcaggtg caggtagctc tggccacctg 12060 tgggtctcct gggggctgca tcctcccagg ttgggctgtg cccttgcctc caaggctgaa 12120 cccacccctg tctttcagag caaggtgaaa tacatcaagc agaccagcgc catcctgcag 12180 cagcactacg gtggggacat cccagcctct gtggccgagc tggtggcgct gccgggtgtt 12240 gggcccaaga tggcacacct ggctatggct gtggcctggg gcactgtgtc aggcattggt 12300 gagtagagga gggcggggct ggctccagcc cactggctgc tcttgggatt ccccacatcc 12360 ttgtgacctg tgactccact tccagcatgc tggtcctcca cccagcccat agagtcagaa 12420 aggtgctccc agggtggagc caggccagcc ccactcagag acaggtgctg gggcaggagg 12480 tcacatgggc tgagcacctg ctccgtgcag ggctctgaga gaggccccgg agctggactc 12540 catctgcgtt gtattcggga gaaatgtgga gcgaggaatt ccccactcgt ggagtggaaa 12600 ccctgatggt tgtgcagggt gctcttgggg cctggcttgg gcccagggcc tctgggaagg 12660 cccccaaggt catccttcac ctgagagctg cagagcaagg tggggtgagc caggccaaga 12720 ggaggaagtg tgttcccagc agaaggaaca gcatctgtaa aaccatgatg cgagagagag 12780 ggccaggagc aggaagttct ggaatgagat gagggcagag tggggaggta aggactgagg 12840 agggaggagg aagagtatcc cctcagcagg tggggtgggg agggaggtgc tggggggata 12900 aagggggagg gtggggaggg aggctctgcg gggacaggag gggaatggta gggagggagg 12960 cgctggggga atgggggaag agggtgggga gggaggcgct gggaggatgg ggggagggtg 13020 gagagggagg tgctgcgggg agaagagggg agggttgaga gggagaagag gggagggtgg 13080 ggatggaggc actgggggga gggccctcct tgaatccttt tcccaggtcc tggtgtctct 13140 tcctagcacc ggaggcttct tggcagttgg gtgcagacag acccctgggt ttggggtggg 13200 gctgcctcct cctcggcttt gtccagagga tttggggctc ctaaggccac acgcagccgg 13260 gcccagccag tccagaaacc agggcttggc cctgccctct gtgtgccccc atcccaggcc 13320 cctttgggac tcctgcaggg ggcctgtgcc ggaggcgggg ggcttgcagc actttctggt 13380 gggcaagagg gccaccaagg gccgggggcc tctattctga gccggggcca cctggtgagg 13440 ctgaacagcc acagcagccc caaagagcca gagccaggcc aggtgcgccg gggcagggcc 13500 tcctcccgac tgagactccc agcgtcacca cctgccagcc tctcagtgga cacttgagct 13560 tatctgggcg gctgtcctca gctgcccgtg tccctggggt gctgcatcgt ggttgggcag 13620 ggctgtgggg gaaggtccct gcccgcagcc aggcagggaa cgggctttgg gagcagcggg 13680 cacaagagac agccatgtgg aaatacctcc ctctccaggt gtctgtgggc ctgaccacct 13740 gcaaggagac cccagggctg cctcctaggg gttccccgaa agagaaacgc tctcagttaa 13800 aatgtcagag ctggctgggt acaagggctc aagcctgtaa tcccagcact ttggaaggcc 13860 gaggtatgtg gatcacctga ggtcaggagt tcaagatcag cctggccaac gtggtgaaac 13920 ccgctctcta ctaaaaatac aaaaattagc cgggtgtggc caggcgtggt ggctcacgcc 13980 tgtaatccca gcactttggg aggccgaggc aggcagatca cgaggtcagg agatcaagac 14040 catccaggct aagatggtga aaccccgtct ctactaaaaa acacaaaaaa ttagccaggc 14100 attgtgtcag gcgcctgttg tcccagctac tcgggaggct gaggcaggag aatagtgtga 14160 acctgggagg tggggcttgc agtgagctga gatcgcgcca gtgtactcca gcctgggcga 14220 caaagcgtga ctccgtctca ccaaaaaaaa aaaaattagc cgggcgtggt ggcaggagcc 14280 tgtaattcca gctcctcggg aggctgaggc aggagaatcg cttgaaaccc agaggcgaaa 14340 gttgcactga gtggagatcg caccattgtc tgtatccagc ctgggtgaca gagcaagact 14400 ccgtttaaaa aaaaaaaaaa atgccacagc cataaattgc tggctccggt cccagctctg 14460 cacctcctgg ctgggtgact ctgggccagg cccttggctt ctctaagctc tggccacaaa 14520 gtgggtgagg cagtcctcgt cattcactgt ccaggtgggc aggaggctca cacaacgtga 14580 cgtggcctga ctcagccttg aagcatggcc acttccgtgt tacagaggag gaaactgagg 14640 ctcagagccc caggggtgtg acccctcagg ccttgtggtc tccccacacc ctcggacacc 14700 tttttctagg cagcagcgaa ggagctggtg caggcctcgg ctttctcttt gggaaacacg 14760 ggaggaggag gcagggctgg ggctgcagct ggccggggcc accgggtggg agaagggagc 14820 cccagtgagc agacgcctgg ggtggccagc tgaggggagc aggagccaga acccaggtgg 14880 acagcagctg cggccggcca gggcatgctc ccgctgtgtc cctgaccgct gcagtggcag 14940 gtgctaggtc tgcaggcagt gacctcatgc cggcctgcca ggcagagctg ttgccaccca 15000 gcctggtgcc cagagccagt gcttatgccg agaggagcct caggccacag gagacagaca 15060 gagggaagcc tggatggacc cttccgggga cagggccacg tttctgggga ggctgagggc 15120 tgagaggtgc ttcggagtcg ggatcctgcc gggcctcggt ttcagcatcc gtaggacctc 15180 atgaggactc actgagctgg ccaatctctc tggcagggtc tggcccccag caagcgtttg 15240 tccaagcgag ctgtcgctgt tattgtgggg aatagagctc caagcagagc cgagtcatca 15300 cccccaggcc ctgcccaaag cagagacccc accacccaca catccaacta gcaccagtgt 15360 tgggagtggg cagcccagaa cagagccccc caggctggct caggtgatgg gagagaggcc 15420 tgcaccccaa cagagggctc agcccctgcc ccagcacctc aggggcagcc aagatggtca 15480 catgtaggct tgcagccagg gctttgcggt tccaatgtct aactggaggg ccacgggggt 15540 ggtggcagac tcgcctctgg gcggggaggg gcacgggcta ggctggtgga gtgtgcccct 15600 gttcaccccg cttggcctcc cagcagcagt ggacacgcat gtgcacagaa tcgccaacag 15660 gctgaggtgg accaagaagg caaccaagtc cccagaggag acccgcgccg ccctggagga 15720 gtggctgcct aggtatgagt atgtgggggg cttcctaggg agaagagctc accccgcccg 15780 ccctctgtca gcactgaccc agcccccacc cccacaggga gctgtggcac gagatcaatg 15840 gactcttggt gggcttcggc cagcagacct gtctgcctgt gcaccctcgc tgccacgcct 15900 gcctcaacca agccctctgc ccggccgccc agggtctctg atggccgcat ggctctggcc 15960 gaggtgccgc tgtggccacc gtctgtgaag tggctttacg cttcaggaag ccacgcctgt 16020 tgaataaagc tttggtgtgt ttgcagatgg gatctggctg atgtctgtcc ctgagggggc 16080 agagagcctg ggaatcgcat acaaggatgt gttcgtacac acccgtgctc gcgtgtctgg 16140 agcagggctg cctgggaggc cggctgggga cgtgacaatc tttgctatgt actcagggag 16200 ggggaggggg tgtgcatgaa cctgggaggg aggaagtggg gagagccagc tgcagccagc 16260 tgttggaagt ccgctgggga agcaagcagc ccccgggcag ctggctgggg accctggccc 16320 ctcatgctat ccaccgccgg ccccccagct tcccagcccg gacaccgcca gctcctgaac 16380 tttcatgccc tcaaagccca gcctctgcca gggtcccacc cctgtttaca gagctacccg 16440 gccttgaaag ggacactggg gacccaggca gggcgccaca gggtacaaag cttgacctgt 16500 gactgctaga ggtcgcaggg tgaattgggc aaagggtggc ccgtgtgggt gttgtgtggg 16560 gccggatggc ttcacaggga aggtgaaggt gggaggctga gtctgccaaa taagagagat 16620 gggcatgggc ccaggatgtg ccacacagca gggggtccca tgggggtcag cgggggagat 16680 ggagcagggc tgggagcaga tggatgcagg gcacgggctc aggaacgaga ccgtttccag 16740 ctgctgagac tcggggaggg ggctccctga aacagcctca tccctccacc cctctcaccc 16800 cacggggagg aggctcagaa aagacagagg cgtgtgggtc ccaggcaggg cctgtttatc 16860 ctgagagcgc gcatgcgcta tggcttacga ggcaacagcg gtgccggtcg atcggtggtc 16920 ggttcggggg tgcggggccc gggagggaag tgcaaagtca acagggtgtc cacgggggag 16980 cccgccaagc agggctgagc caaaggccag gcgtccttcc cgggtgccgc tctcacacac 17040 ctacgttccc caggcctggg agctgccgcg cggaatgagg ggcctgtcca aaggccgccc 17100 tcctcgggga cttggggcct ccatcctcag gcccctcgga aagcccaggc ccccagcagg 17160 gcacaggcgc acagggtacc tgggtgggga gcagggtgtg gcctagggac ccccacacca 17220 gggcaggtgg gcaggggcag ctcctacggc cacatcaggc ctccctggcc ttacccaagg 17280 tccccacaaa aaggctgggc gccccaactt ggccactggg aagtcccagg gactcccact 17340 caggacggcc gctgctgagg ggagggggcg gggaggaaat ggtttgcaga gaaaggtttg 17400 ttttattgca attatttaga gcgcgtccca agggggaggg gaagggggag gggaaggggg 17460 gggggtctct ggtattaagt ggaaacatgt gtggagctgg agatcttttt ggaaaaaaag 17520 caaaaacaca aattcctttc agtcagcagg ccccggcaga gcagcaaagg ccctcgcccc 17580 gcggctgccg cgcgctcgct cgctctctct ctgtctctct ctgtgtctct ctctctctct 17640 ctctgtctct gtctctgact ctctctcaca tctctgggtc tctctccccc tatcttgctg 17700 ccacaggccc ccagtacctg gtgggcaggg gcaggatggg ggctcaccgg ggctggggct 17760 gatttctggg caatggcagg accaccctcc agtccactga ggctggggga gctcggggca 17820 ggctgaggcc caaggtccgt gcgggagggg tcccagggtc ccgagacagg caggaagggg 17880 ctcagaagtt gctgaagatt tcacgcttcc tgttccagtc catctgtggc gcgcgcttgt 17940 tgactcgcat ggctcgagcc ttctccttgg cctcggccgc cgtggggctc aggtggaggc 18000 cgctctcctg gaagggatct tgcttccagg cactgccatc ctggggtgag cacggtgggt 18060 ggggtgtctg gagtgagccc tagtcccaca ccccagacgg tggcccctcc tagggagcaa 18120 ccaacagagg ctgcctgctg gggctggggc tcacgaggac ttcctgaaca gagaccccac 18180 tgcccgggct gacatctcca cagacgccta ccccaaggcc tctagcaacc ccacgtgtga 18240 gctcaggagt ggagaacatc catacctcag tgtccttgtc ggaaccaggc aggtcacttc 18300 gggacgagca cgcagagcca ccattgagct gggaaaccaa gggcagattg tggtttcaca 18360 gacacacaca acacctgcac acgcacacat gtgcacagag gcacaccccc ccccagtgtg 18420 tgctcctcca ctcggcaggg ggcctcgggc ctctggtgga ctccagatgc ggcggggcag 18480 gcaccgggcg cctggcagtg acaggcaggt ggcctggccg gctcatggtg cagagggggt 18540 tcaggtgcag gaatggccgg cgtgagcaac gcctggggtg aggccaccgc cagctccctg 18600 aggaggcaga gactggaggg caactcctta ccaggtggtg cccaggagag gacagaaggc 18660 agtggccccg accccagggg ccccacgtgg cttgtgtgtg gcacgaccca ggatgagacc 18720 cacaggggca ttaaagggag gtgacagggc taaaatcggg tgtcactagc acacctcgag 18780 gacggatctc cagggagaag ggggcctctg tcgggcctgg gtacccccag aggcaccctg 18840 tgtctcatgg gcaccccacc ctcttacctg ggcagggctg gttccattgg tgacgggtga 18900 cggcagagga cctgtgggga cagcgtgtca gtggctgctc agccaccaca ccgcacccac 18960 cctgtgccct gggccgtggc ccaccttcca cgtgctcctc ggtgggtgtg acccgaagcc 19020 gcttgaagtg ttcatctgtc tcggggtcca cgaccagcag ccgggcctcg tcctcccgtg 19080 ccttgatgct ggccaccacc tcagcatggc gcagtccctc cacattctgc ccgttcacct 19140 gccgccacca gcatgtatca gccccgccat gggcccagac agcccccaac gccgcgtggc 19200 caggtgtggc atcaaatatt catcacagcc accgcccacc gaggcagcag gaggcgcacc 19260 agctcaggtt cccagcgtct ccctcctccc tgcaaggacc cagggcccca gtgtggacag 19320 gtgcggggca ctcggcaccc cgcagccctg gtgggccggt acctcaatga gccggtcctg 19380 ggcgcggagg ccagagcggg cggcaggtga gcccgggtcc acagagcgga tgtactggcc 19440 gggccgggac ttgtcactat gcaggttgaa cccatagccc tgaggtccct ttcgcaggtg 19500 gcagagccga gggcgcagct ccctcagggg cccactgaca tcctgcaggc ccaacggaca 19560 gggtcagtct cttgctccag cctcccgcct ccagaggcca ctccccggtg gtgccgccac 19620 tgcccaaact cggtaccgtg ccccccacgg gcaggcccag gtctcagtgg caaacactcc 19680 gggcacccag gctgcctgtg acagagcttt agctgtggga acttgggcaa agcctgtttt 19740 caaacccaga agcctccccg acgggcccag ccgccttccc gggttgctgg gagaattc 19798 <210> 31 <211> 6330 <212> DNA <213> Homo sapiens <220> <223> Genbank Accession No. AF037062 <220> <221> unsure <222> (1)..(6330) <223> n = a or c or g or t <400> 31 ccaggttttc cctcccttcc cccactcagc tgcaggaact cctttttggg gtttggatct 60 ggtatttttc tattcagctc cgagcttggc tctcctgggg aatcctggga gtgaaaggaa 120 ggagctgggt ttatttgcat gtactggtag tcatttgcat cacatccaaa aatggccaaa 180 attataaccc ctgattcttg gctgaactgg gactgctgca atggaatatt attcccggaa 240 accaccccca actagctgga gctaatctcc tccctcctcc aaccccccat tttggcccag 300 gcctacataa accaaaaaaa gctggaccat aaggtgaaaa ccctacaggt ccaggctgcc 360 caatttgcca agcaaacagg ccattggatc gaaatggtga aaaacttcaa ccaggcactc 420 aaggtgggcc atactcccta cctcaccacc ccaatcctgg gcccccattg gctgcctcca 480 gtcaggttac ctcaggttta ggttaaggag gaagtagggt ggtcccagaa accccatcta 540 tagccccagt gtcagaaaag gttgagaaag aaagaaaagc agttggtggg tccaagttaa 600 agccttttcc aggagatgaa taaaacttat tccccaatgg aagccatagt ctacccattc 660 tgattcctgg gtcccaactc ctctccccct ttccaggaaa ttggggatgt ggagaatggg 720 cttggagcat tgagctggaa atgcgcacca ttgccaatgc aatggaatat gtttacaaag 780 ggcagctgca gtttgcccct tcctagcccc tgttccctcc cccaacccta tccctcctac 840 ctcacccgca gggggaagga gggaggctga caagccttga ataaaaaaca agcctccgtt 900 tttttgtggt gtgtttcaga gaggtaatag ctccagtgtc gggggtggga gtggaaggtt 960 caaaggtggt ttccctgagg gacaggtacc ttttggggag agggtggaaa tagcttcctt 1020 ttactatccc aaattttttt tcctccatgg cccttgtgca ggtgtttgtt aggcaagcag 1080 agggtgggag ttcccatccc tcctgagaga aggtcctagt agccctgccc caagcttcct 1140 aattcaggaa ttgtttccta cagaagagaa acaaggcaag tacacctggt ccccagctct 1200 ggctttctgc ctctccacgt gctcatggcc tctccccagg ctaactctaa gcagtgtcat 1260 gagtctgagc caggtgggag attaattcct gggggcactt cagggctgag aagggggagg 1320 aatgacaggt ccagtaaccg ttaccaacag agcagtgcag ctgccatcct tgacagctcc 1380 ctcctccttg gagaccatga catagatggt caggaaccca ggctgagaaa gacagccaag 1440 gggtgggggg agcctaggca aatctggcct ctgccaagtc ctggcttcag ccaggcaagc 1500 tccagcctcc ctggctcctc ctcctcctca gtcctatccc caccctgtca cacatacact 1560 taatacgcct ggcatccaag tccacccact ccggactttg gccttagcag tagttagtgt 1620 gggaggctgg gaagactggg agcagtctct taaacaaaag caaaagaata agcttcgggc 1680 gctgtagtac ctgccagctt tcgccacagg aggtaagtgg atctgggagc tgggggaact 1740 gagaagacta gccagatatt acatgtattg ccaactcaaa actttcagct tttaacatgc 1800 ttcctcacac attatcccct ttgatcctcc acaactctga ggtggacctg gtgggtctta 1860 gccccacttg gtagatgaga aaataggttg agagagacag tgagatgctc agtatcacac 1920 agcaaacctc ttggccctat acatcattcc aaacacaaga cccaggttgc atatagaagg 1980 ttcagtgtcc ctggtttaga aggagaggtg gtgtgaggca agcaagaaga tgcctctgct 2040 gcactccagc ctgggcgaca gagtgagact ccatctcaaa aaaaaaaaaa aacgatgcct 2100 ctgctccata cagcaggtct gtacacagga tctggctcat gtggttttag ttaagttagc 2160 cacaaataca gggtctgccc acatctttgc tttgaacaga tgagccatgg ttggccaatt 2220 atctgccaac cagataattt ctcaatatgc tcacaccaga tgcttccagc tagggagggt 2280 attaggggaa agggcttgag ggccacagta aactggacaa gtttttctgc ccagcctagg 2340 ctgccacctg taggtcactt gggctccagc tatgtggctg cctcttctgc tgggtgcctt 2400 actctgggca gtgctgtggt tgctcaggga ccggcagagc ctgcccgcca gcaatgcctt 2460 tgtcttcatc accggctgtg actcaggctt tgggcgcctt ctggcactgc agctggacca 2520 gagaggcttc cgagtcctgg ccagctgcct gaccccctcc ggggccgagg acctgcagcg 2580 ggtggcctcc tcccgcctcc acaccaccct gttggatatc actgatcccc agagcgtcca 2640 gcaggcagcc aagtgggtgg agatgcacgt taaggaagca ggtaagtatg gtagaccacc 2700 aggaatatgg tgtggggtgt cctgatcccc acagtcaccc caggagtcac ctgcaagggc 2760 tgtggtaagc taaagggaca atttgaggag aagcagtttt cagatgctcc caggaagaag 2820 agggagctgt gggagtgcct cacctacccc cagcatcctt ttcatctccc cacagggctt 2880 tttggtctgg tgaataatgc tggtgtggct ggtatcatcg gacccacacc atggctgacc 2940 cgggacgatt tccagcgggt gctgaatgtg aacacaatgg gtcccatcgg ggtcaccctt 3000 gccctgctgc ctctgctgca gcaagcccgg ggccgggtga tcaacatcac cagcgtcctg 3060 ggtcgcctgg cagccaatgg tgggggctac tgtgtctcca aatttggcct ggaggccttc 3120 tctgacagcc tgaggtgagg ggtacagggc tctgggttcc aggactaaca gcagcccact 3180 caacaaacgt gggccagcag aggtggttaa aatacagcac attggaatag ttaaaaagag 3240 acagtttagg gctaaacttc atgggttcaa tgaagtctac ccttatgtaa gctttgtgac 3300 cataagtaga ttacttctct ttacccattt ttaacgtgtt tgttttttgt tttttgagat 3360 ggagtcttgc tctgtcgcca ggctggagtg cagtggcgcg atcttggctc accacaattt 3420 ccacccccgg ggttcaagcg attctcctgc ctcagcctcc cgagtagctg ggactacagg 3480 catgcgccac catgcctggc taatttttgt atttttagta gagacagggt ttcactatgt 3540 tggccaggtt ggtctcaaac tcctgacctc gtgatccgcc cacctcagcc tcccaaagtg 3600 ctgggattac aggtgtgagc caccacgccc ggccttgcct ctcgtcttta aacaataagg 3660 ttcaaagttc cgtgggagca caaaggagac atgatgagga caacgggagt tagggcctga 3720 gtttttttgg tttttttttt ttaagcgttt tgctcttgtt gcctaggctg gagtgcaatg 3780 gcgagatctc agctcacagc aacccctgcc tctcaggttc atgtgattct cctgcctcag 3840 cctcccgatt agctgggctt acaggcacgt gccaccactc ccagctaaat ttttaggtag 3900 agatggagtt tataccatgt ggccagggtg ggtttgaatt cctgacctca cctgatccac 3960 cggaccggcc ttcccaaagt gctgggatta caggcatgag ccaccacaca cggcccaagg 4020 cctgagttct tagcaggagt ataaggcgcc taagcttagt ctaccttcta aggaagcctg 4080 cgtttgtcac catcactcag caaataaccg gaattgtctc ctgtctctca gccttaattt 4140 ttcaggcagc atcatgggac acatactttt agttttgaga caaggccttg ctctcaccca 4200 gggtggagtg cagtggtgca gtcacggccc actgaacttc aaactcctag gctcaagcag 4260 ctcaagcgat atccgcctca gcctcctgag tagctgagac cacaggcgcg tgccagcatg 4320 cctggctagt atttttttac agatggggtc ttgctgtggt gaccagactt gtctccaact 4380 cccggcctca agcgatgctt ccgcctgggc ctcccaaagt gttgggatta taggtgtgag 4440 ccactgcata ctggaacaca tactttatac ttgaattttt ttttatcccc ttccttcgtg 4500 ctcctaacct atacttggat ttctacatct gtgccagggc agtgggatgt atccccactt 4560 tccccatcag cttaccctcc agcaaatacg agactatacc cttcaatatc cagcactcag 4620 ggctcaacca tgtgttttgg gagcaaggga atggggttcc tctaggtcag gaatcggcaa 4680 actcagtact caagccagat ttggccagct gcctacaagc tgataatggt tttttttatt 4740 tttaaatggt tacattgtaa actgttatat aagtacctga taatatcatt aattttgttt 4800 cttggcctgc catgcttaaa atattaactc tctggccctt taagaaaaaa acgtgctgac 4860 ccctgctcta gatcaaagaa aacaaacctc aaaaatactt tcctccctct accccacttg 4920 acccttgtcc cggggcagta ggcatctccg tcaaaactct tgtccctggt ctgtggtaac 4980 tttctcagct ccccaaccca tgtccctcaa agtcccctcc ctatagggca agaacccagc 5040 aacttcgctc tgccccgact ctaggcggga tgtagctcat tttgggatac gagtctccat 5100 cgtggagcct ggcttcttcc gaacccctgt gaccaacctg gagagtctgg agaaaaccct 5160 gcaggcctgc tgggcacggc tgcctcctgc cacacaggcc cactatgggg gggccttcct 5220 caccaagtgt gagtagccag gcccacacag gggcacatga agggaaacaa gtaccagaaa 5280 ggccagtcct gcataagcct gctaggaggt gggtggggca cccagggcag ggttgagggt 5340 gaacaggatg ttacaanagt gcccaggcca tgtggaacct gcccactccc cacactgagg 5400 aggggactga gggtgacaag cccagggccc caaaaaacag tacctaanat gggctggagt 5460 gaggaaggga aactgattgc aaccacctat ggggctgcag acctgaaaat gcaacagcgc 5520 atcatgaacc tgatctgtga cccggaccta accaaggtga gccgatgcct ggagcatgcc 5580 ctgactgctc gacacccccg aacccgctac agcccaggtt gggatgccaa gctgctctgg 5640 ctgcctgcct cctacctgcc agccagcctg gtggatgctg tgctcacctg ggtccttccc 5700 aagcctgccc aagcagtcta ctgaatccag ccttccagca agagattgtt tttcaaggac 5760 aaggactttg atttatttct gcccccaccc tggtactgcc tggtgcctgc cacaaaataa 5820 gcactaacaa aagtgtattg tttaaaaaat aaaaagaagg tgggcagaaa tgtgcccagt 5880 ggaaggctga ccccatttaa gtgccaacta ctccaaaccg acatgctcac ggtctctggc 5940 ctgttcagtc cctgcaaaac agctagcacc cacagtgggg cgccagggaa ctgcctcaca 6000 tctacagctg cacgtcgggg agtggccatc aaagggcact ttaatacatt tcccttattt 6060 tctgaagggg agtaaggttg caattcagtg tctgtactgg gaatggtctt catatttctt 6120 gggggagaag agcaggtgat gagggttctg ggccaggctg ggtggcttcc atggaagaaa 6180 aggcaatatt cacataaatt ctcctgctaa ggacactgac cacacaggtg tgcaaggcaa 6240 cttatcatac ttcgaaagga gctggatccc ttgaggattg gccaggaagg gaggtgctgg 6300 gcccttagcg gtgcacagaa ggccaggaag 6330 <210> 32 <211> 10884 <212> DNA <213> Homo sapiens <220> <223> Genbank Accession No. M35878 <400> 32 ctgcagacct gggacctcaa gaattgcatt tgatgccgaa cccagctcta atttcagagt 60 caaggtctct gcgagtattt aaggaacgga tgtaaacctg ggggattcgt tttgtttcct 120 tcaattttcc aatgaaatca gagatcctgt tcttgggtgt caacgcagat actagaagga 180 ggtgatacaa gagaaaggaa acagcaagcg acgattatgg cacggtttcc tgtaaacaag 240 gttgagtgta gccacagcct gagcactgtg ggagaagagc tcataagaaa atgacggtgc 300 tgggccttcg tcaccccggg gccctccatt gttcttgtct ttggtctctt tttatttgta 360 gaggtccaat tatttattta tttagtacaa gagggaacga aattgatctt tccattctaa 420 aaggagagta tatatgtata aaaggaagct gtatagatat gggggaagag gtggacaggg 480 ggaaaagggg agaggacgag agagagaaag ggagggagag ggacaaggag agacactggg 540 cgagagatcg attaggagag acagaaatga tgaatgaaga ttaacttcac ccaaggcttc 600 gtcgctggag gggaatggag gagctcctga tttgctatta ctactccaaa ctgcaaaggg 660 ctccttcaag tcacctatcc acctcctaag gcaagcgtcc aatttcaaca gcgttcagga 720 aagtctcctc ccgcggaggt ctcaccgctt cccactccac ccccacaaac tctttggaaa 780 agtgccttga aaaatttaat cctcaatcca atcctggacc accagcgtcc tctgttggtc 840 accgaaggag ggggtgcgca gacaaaactg aagaaactcg agtgccagag aaggccgaca 900 ggagttacag cgacctcagc gcgcaattgc gccccgaact ttactgaaaa gtgtttagat 960 tgcagagata agctagaatc ccaacgcatc gagaatacag taatacgaag tcgccttcaa 1020 aaaatgacaa tgaaaattgc ctattaaagg actatttggt taattacgtt tcagcagtgc 1080 ccagtttatt gtctttatta ttcttttgtc gtgggtgtaa actccatttg aaaacataat 1140 cagggagaat acccaagaca agaagaacag ttgtcattta aaatatttga aaagccctgc 1200 cttaaggagc attcgcttgc cggtccactc ttaattgggg acttgcggtg tagcaacacg 1260 tgagagtctt cttgcgttga gaagtaagcc tggaaaggcg aaggccccgg ggcatcttca 1320 gatgcgtatt tgtgggcccc tggggatata aacagcccag cgggtgtaaa ttaaaccccg 1380 cagtgccttg gctccctgag acccaaatgt aagtcagaaa tgtcccaaga cttcgcctgc 1440 caacggaatt aaattttaga aagctccacg aggtacacac gaatgcggag cgctgtatgc 1500 cagtttcccc gacaccggct cgccgcaggg agacctcacc ccgagagcgg aaggggtaag 1560 ggcggcgggg tcaaggagat cgggggtgct gagttggcca ggagtgactg gggtgaccgg 1620 gggtgctgag gtggcctgga gtgccggggt ggccgggcac accttggttc ttgtagacga 1680 caaggtgacg ggctccgggc gtgagcacga ggagcaggtg cccgggcgag tctcgagctg 1740 cacgcccccg agctcggccc cggctgctca gggcgaagca cgggccccgc agccgtgcct 1800 gcgccgaccc gcccccctcc caacccccac tcctgggcgc gcgttccggg gcgtgtcctg 1860 ggccaccccg gcttctatat acgggccggc gcgcccgggc cgcccagatg cgagcactgc 1920 ggctgggcgc tgaggatcag ccgcttcctg cctggattcc acagcttcgc gccgtgtact 1980 gtcgccccat ccctgcgcgc ccagcctgcc aagcagcgtg ccccggttgc aggcgtcatg 2040 cagcgggcgc gacccacgct ctgggccgct gcgctgactc tgctggtgct gctccgcggg 2100 ccgccggtgg cgcgggctgg cgcgagctcg gggggcttgg gtcccgtggt gcgctgcgag 2160 ccgtgcgacg cgcgtgcact ggcccagtgc gcgcctccgc ccgccgtgtg cgcggagctg 2220 gtgcgcgagc cgggctgcgg ctgctgcctg acgtgcgcac tgagcgaggg ccagccgtgc 2280 ggcatctaca ccgagcgctg tggctccggc cttcgctgcc agccgtcgcc cgacgaggcg 2340 cgaccgctgc aggcgctgct ggacggccgc gggctctgcg tcaacgctag tgccgtcagc 2400 cgcctgcgcg cctacctgct gccagcgccg ccagctccag gtgagccgcc cgccaggtgc 2460 gctgcgtgca gcaccgccac tggcgccgaa gggcctgggg gttgctgggt gccgctgcgg 2520 gagactccgc ttttcttctc actggagata atatgtgggg aaactgaagg cgctccggga 2580 aaggtgaagg cggtcgccga gggaccctcc ccagccggcc ctctacttgc tcgattctct 2640 aagtgcagag tacttgtaaa ttgcaaagcg ctttcagtga aaatgggtaa aggtttccgg 2700 agctgagggg agcggtaccg atgtttagct gttggaaaga tcctggacac aggagattct 2760 cctcgccccg cacgggtgca cacggactgc aatcccaggg atgcttgggg atggggggat 2820 ataggcggat ttggaccaag gaaggtgggt aggcacgttg taggaaatag tacctctctt 2880 ttaaaatact gactttgcac agccttttgg tttgcaaagc aatgtctagt cccggtatgt 2940 ccaaaaacaa gtaaagtgga ttcgggtttt gatatcttct gcggttggaa aacctgaagc 3000 tgaaaaagaa gtaacttctt aaggttaccc agcggccaca acagagtgta ggtttgaact 3060 ccgcgtgcca ctttcagtac cataccattc ttacaactcg ggccacccct gcacctgcgc 3120 cgacctcaaa caaacttcca ggtgcgtggt gggtgcgggc aatgtggact aagtcaattt 3180 caatgacacg gcaagggaat tggaatcagt cctaggctgt ctcccttctt aatctgaaat 3240 gggggggggg aatgagatgt tgttaagggg agccccagaa gaggaaaaat gcaaacattt 3300 ggcagagtta ccctcttgct tagccactat cagtatcagg cagacagcga ctctggtaag 3360 ggcatcacat tgttccctta aaaaaaggag cgggggttgt ttaaatggat ttggcagctg 3420 ttctttcaag cattcttagc cagcctcacc tagttatatg agaaataaag ttcctgcctt 3480 gcacagctga aggctgggag aattctcccc atcctaattc ccccaactcc ccaacgatca 3540 cgttggacag atgtcactgg gcaggccccc atctagggct agcaggatga acagtccctt 3600 tataatttat gtagctgtag agttccacgc ccgggtgaag ttattttctg gctcggcaag 3660 gctggctctg ttcacccctg agaaatgctg gattcatgga aaggcaagat gcctgaaaca 3720 tacactggct ctggtcagct gttaaagctg ctggaggcat ttgtctctcg gggcaaagtt 3780 atgtcatttg ccaagtgtcg tacattattg tgcattttgg ggtattcaaa aagtgatctt 3840 agaaatactg atacacatcg tcattcttgg gctttagcaa tcatcatgat taccacctta 3900 gtagcactgt agtataggtt gatgtgagtt ataagattat aaaaagatct aagtgacttc 3960 tagaatctat ttgacaaaaa aaggtaaatt ttcgacagtc aaaagtcaca attatctgtt 4020 gcttaaatag aactgttttg tcttcatgcc ctagtctgca gcccaggcat taagaagaaa 4080 ccaaggaaat ttaagaaatt actcaaggtt cttagaaaag aagtataaat acgtttattt 4140 acatgttctt agagtattta cattcttagt atctctttta tctcagtatt tccttgaaaa 4200 agaaagcaag ctaagattaa aagaaattga aaccaaatcc tcgcaggtag ggacctcctc 4260 tgtgaggctc tgtgctggac cctgggaatg tgtgcttccc aaggtatgaa accccttggg 4320 gaactttaca gcaggacctc agtgagctgt ttggcaggtg aggaaactaa gacccagaga 4380 ggagagggac tttcctaagg ccctggtgag tgacctgcca gtagccactt ccaggggaga 4440 gcagagcatc tgcagccaaa tcattgcagc cccaggtagc tttctagata gactgtggac 4500 cagatgggcc acctgagctc cctgctaggg ttacacatta tagccctgtt tgtgtagtag 4560 agaaatttca tgactctcaa ttgtggactt aagccgatgc ctccagacct tggcatggtc 4620 cacaggccct gggagcatgg gctctgaatg tagcctttga tccccatagc ggtcttacag 4680 cccctccaag ttcattctga agaaggaatg gagtgagaat cctggctgca gatccagtct 4740 tgaatttagt catatactta aaattccaat tcaactgtta acattccagc atccatttta 4800 agcatcagac tttcttcatt tagcactttt tattataaaa gggagatctg ctggaggggg 4860 atttctccta ccccaccccc acccagggaa ggaaaagctc tttggcactt agaagtctga 4920 gccgtgagtg ggactttggc attgtctgca tccatgtgct gctgtgttca cccggggtga 4980 aaaggactca cttaggcagg caccagcaag atgcacaggg tctgtgtaga ccttgagttt 5040 tagagatgta acggggacct agaaaacaag ccaccaacat gcttgcatga ttctgagccc 5100 ctgaggcaaa acgctttgca ggtaataatt cagttttccc atctgagctg gacaccaagc 5160 tcttataagc gtgtttacct ggtagcattg aggacggtac tggtcaacct tggaattccc 5220 ataagggctt gttacaactc agactcgtgc cgccactcca gcgtttccgg agtggagaat 5280 gtgcatttct tccaagtccc cgggctgccg ctgctcccgc gggtgggagg accacacttg 5340 gagttgactg caaaatttct gagccggcgc tgcagcagcc tcccgtggct caggtctgcc 5400 ccctgccggt ggaagatgaa gcatactgcc ttcacctact gaggggcact gaagcgtttg 5460 tctgccttct ttagttgcag ctacttagga agagcacctg tcagattgac tttcaaacag 5520 ataacttctt gaggtagagc aaccaccatg tagtgagtag tatgatggaa taatacttca 5580 tcgaggtatt taaaaaaaaa acctcacttg gattgccaac taatattgtc atttacatgt 5640 gacctggttg caacgttaag atttttacaa gactgtgata gatattgatg actctcatgt 5700 gtttgtctct cttgggcgtt ttaaggaaat gctagtgagt cggaggaaga ccgcagcgcc 5760 ggcagtgtgg agagcccgtc cgtctccagc acgcaccggg tgtctgatcc caagttccac 5820 cccctccatt caaagataat catcatcaag aaagggcatg ctaaagacag ccagcgctac 5880 aaagttgact acgagtctca gagcacagat acccagaact tctcctccga gtccaagcgg 5940 gagacagaat atgtgagagc ttttcctctt gttaaaggag gagggcaaga cctgccaagc 6000 ctgggtactc agagcctctt gagggcaatt cttactcaac aaaccccagc gcctggctga 6060 tgggtgggca acccctagcc cctctgtgcc ctacctctct cctctcctta cataaagaat 6120 attgaccctt ttggagaatc ttatgaggat caagctgaaa taacactctt aaaagcatat 6180 gggatgtcat aaagacctct gcagataatg aaaatattct cataaagata gttttattta 6240 cttcatcctc tatgcttgtt gacctgctat tggttccatg ccagcttctg tgccttactc 6300 tgggaagagc aaaaaggaga cagggagtga tggttagctt attcggggga ctttcgtgct 6360 acatcagaca taaggtatct gaggagcaaa ttacaggtcc cacttttggt agttgtgcag 6420 catcgtaaga tttttaaagc acacattcta gagtaaaaac tgtgactctg ttgctctggt 6480 ccttcctgat ccccagggtc cctgccgtag agaaatggaa gacacactga atcacctgaa 6540 gttcctcaat gtgctgagtc ccaggggtgt acacattccc aactgtgaca agaagggatt 6600 ttataagaaa aagcaggtga gtgaggtcct cagtgtgttt tcttcctctt ctgttgacac 6660 agaggagaaa cccatgtcac cagcgcccag gctcttgtgg ccatagctct aactctgagc 6720 ctgtgcagca ccagtgccca ggacttggtg ccagtctcag gaggtcagac caagggctgc 6780 tttgacttgt tgctctgagt gctgctatat tggccataat cctcaaccct agtgcctttc 6840 caccacccgc ttcccactcc tgtcctttca atggttcacc cacaggcgga caagatgctg 6900 cccagtggca ccctttataa actgcaagtg gacatgttaa cacatttgtt aatgctgcgt 6960 cagggagtga catttcaaac aactattata gtcagtttcc aagaagtgtg acatgaggtc 7020 ataccacaaa aaagcttacc ctgaaatccc acaatcgtcc cctttcctac tgatgccttc 7080 ccgatagtga gcaggttgca atattaagat tttgaaaagg ctgttgctag atgttggtga 7140 ctcgtgtgtc tctgtctccc ttgggctttt caaggaaatg ctagtgagtg gggggatgac 7200 tgcagcatgg ccagcttgga gagcccagcc atccccagca cataccaggt gtctgtcttg 7260 gcgtggaggg gatggaactt gaaatcagac actcggtcca tgctggggat ggccagtctc 7320 tccaaactgg catgtggtct tcctccgagt cactggcatt tccctagaaa gtccaagtga 7380 gaagaaggca tgagagtcat caacatcaaa caacagtctt ttcaaaatct ttatattgca 7440 acatagtccc attcctggaa aaggaatgga gtgagaatcc tggctacaca tcagccccaa 7500 atgtagtcat tgcctaaaat cccaattaac ctgaaaatga tcaaacaaat ttaagatata 7560 gtaatattaa gctgtaataa atatgcttct ataggctttg tgttatgtga tggcactatt 7620 tcaattggct ttctaattgg acaattgata ctatgctatc tacagaattg gcctttggag 7680 acctaagtga gccacagtgg cctcagggtg accatatact aggattcata gcagtggcca 7740 cagtcagaag cctaagcttt cctccattgc cattgctcgt ttataccacg tttctgtcaa 7800 agtcatattc attcaacaaa gtcatactga gaaggtgtca tgtgaggctg gatgtgggct 7860 ccaaagtcat agctgtgaca ttcgcaggca gcgggatgtt ctcagttcca catttggcag 7920 agaagtcagt caagaggttc tacaagggct ggtgtccacc ttatactcct agaaacacaa 7980 aactgccccc acccccgctt tcttggagca ggaagttaca cccacacgca tgcacaggcg 8040 cacactcagc gggcctaggc agcgtggctc ttgtgttgcc ttagctgaaa tttctgttgt 8100 gctttctcag catagcagag tcacgctggc aaaccatcat gcgccctggc caccgacctg 8160 acaccagacc caggagcatt cacttctctg tcttctgttt ctctcccaca gtgtcgccct 8220 tccaaaggca ggaagcgggg cttctgctgg tgtgtggata agtatgggca gcctctccca 8280 ggctacacca ccaaggggaa ggaggacgtg cactgctaca gcatgcagag caagtagacg 8340 cctgccgcaa gggtgagtac tcaggagggg cagcctgggc tccagggcct cactgtcctt 8400 ggaccagcct caggggctgg gcgtggccac tggccttccc caggcttaca gacccaggag 8460 ctgcagctca gggccagaaa gagcaaagca aataggacag agccctcaga agggtgcagg 8520 gagagggaga ccccatcaac ccaaccaaac aagtgtgggg aaggaggccg gccagtgcac 8580 ctcagggaca ctctgcttta tctcagatac ctcacagcac ctaagctatc attcatccac 8640 acacaaagtg aagattttca aagttaggct ttacccgtga gtctggaggt catttatctt 8700 cacagagaac gtttatcgca gactgctaag atacatgttc taattaagat gtgatgtgag 8760 aacgctgaat gctcgttgga gactcagttg aagtgcagct ttttttctgt caaatatata 8820 atgaatattc tgttagtctg tggctaatat aattttaata aagttaattt aaatctgata 8880 gaaaaatgaa attttaaacg ataattttag agaatgctat tatatccagt cttctttttt 8940 cttttaataa atgagggaac tattggggga aaggaataaa tacattttct ttcattttat 9000 taagacaaat ttagtaagca gaagaaattt gcatgtttag ttataagggt ttcttttttc 9060 cttacaagtt ggaaaaaata attctaattt aagggtaact ctttgacaat gaacactgtg 9120 agcagcatct ggtactcgtt gctttgtttg aaaacatgag ttgagacccc agccgcactt 9180 gcagcctagt gccattagcc tgcaggctgt gctggatatc tcagggcaag agtcgagccc 9240 ttttgatttt ggggggatta tttcaatata tttgcttttt ctttttgttt tagttaatgt 9300 ggagctcaaa tatgccttat tttgcacaaa agactgccaa ggacatgacc agcagctggc 9360 tacagcctcg atttatattt ctgtttgtgg tgaactgatt ttttttaaac caaagtttag 9420 aaagaggttt ttgaaatgcc tatggtttct ttgaatggta aacttgagca tcttttcact 9480 ttccagtagt cagcaaagag cagtttgaat tttcttgtcg cttcctatca aaatattcag 9540 agactcgagc acagcaccca gacttcatgc gcccgtggaa tgctcaccac atgttggtcg 9600 aagcggccga ccactgactt tgtgacttag gcggctgtgt tgcctatgta gagaacacgc 9660 ttcaccccca ctccccgtac agtgcgcaca ggctttatcg agaataggaa aacctttaaa 9720 ccccggtcat ccggacatcc caacgcatgc tcctggagct cacagccttc tgtggtgtca 9780 tttctgaaac aagggcgtgg atccctcaac caagaagaat gtttatgtct tcaagtgacc 9840 tgtactgctt ggggactatt ggagaaaata aggtggagtc ctacttgttt aaaaaatatg 9900 tatctaagaa tgttctaggg cactctggga acctataaag gcaggtattt cgggccctcc 9960 tcttcaggaa tcttcctgaa gacatggccc agtcgaaggc ccaggatggc ttttgctgcg 10020 gccccgtggg gtaggaggga cagagagacg ggagagtcag cctccacatt cagaggcatc 10080 acaagtaatg gcacaattct tcggatgact gcagaaaata gtgttttgta gttcaacaac 10140 tcaagacgaa gcttatttct gaggataagc tctttaaagg caaagcttta ttttcatctc 10200 tcatcttttg tcctccttag cacaatgtaa aaaagaatag taatatcaga acaggaagga 10260 ggaatggctt gctggggagc ccatccagga cactgggagc acatagagat tcacccatgt 10320 ttgttgaact tagagtcatt ctcatgcttt tctttataat tcacacatat atgcagagaa 10380 gatatgttct tgttaacatt gtatacaaca tagccccaaa tatagtaaga tctatactag 10440 ataatcctag atgaaatgtt agagatgcta tatgatacaa ctgtggccat gactgaggaa 10500 aggagctcac gcccagagac tgggctgctc tcccggaggc caaacccaag aaggtctggc 10560 aaagtcaggc tcagggagac tctgccctgc tgcagacctc ggtgtggaca cacgctgcat 10620 agagctctcc ttgaaaacag aggggtctca agacattctg cctacctatt agcttttctt 10680 tattttttta actttttggg gggaaaagta tttttgagaa gtttgtcttg caatgtattt 10740 ataaatagta aataaagttt ttaccattaa aaaaatatct ttccctttgt tattgaccat 10800 ctctgggctt tgtatcacta attattttat tttattatat aataattatt ttattaaaat 10860 gttccctgct ttccctttta gcaa 10884 <210> 33 <211> 8322 <212> DNA <213> Homo sapiens <220> <223> Genbank Accession No. D50030 <400> 33 gaattccgtg actccagcac catcccaggc cccagggtac ctggcccagg gttgtgctgc 60 cgcagacttg gcctgtacca tccaggcggc ggtggggagc tggggttgga aaggcttctt 120 ggagtggact cctgggtctg tctgggagac ggggaggaag ggacactctg aacatcacca 180 ggggctgctg gggggccctg gccaccccca gagtcagaac aggcaggtgg ggcaggatct 240 caggtcatcc tatgctacac tcagccattg cgtggcccct ctcctccctg tgcctggcct 300 tttggccagc cctggggcca ccgagaggat gcagcaccga accctccagg agcccccagt 360 gctgccgtct gtgggacagg gacaatccca tccccactgc tactgtctgt gctgtgctgg 420 gcacagagct ggacacctcc aaggcccagc gcccgtagtg gctctcatca tggacaattc 480 acaggcagat ggtggccagc tctgtggcct gcagggactg ggagcggcgc cagaccatct 540 aggccccaac ctatctgcat tatcctggaa gacttcctgg aggaggcttc taagctgagg 600 cccaaggacc atgtcaggtc taggactagg accagtgcag gccgaggcca gagagacagc 660 tgggcttcca ggtagggtca aagtgaggtg ggcagcaggt gtgggggcca ggggactcgg 720 ggacttcctc tccggctggg cccgcctgac gtgggaggca gccagggtta atcatttcca 780 cgaagccttg accccacctg ccttggccgc tctggagggc gctcccactg cccctcaggc 840 cagctcagga gccatggggc gctgggcctg ggtccccagc ccctggcccc caccggggct 900 gggccccttc ctcctcctcc tcctgctgct gctgctgctg ccacgggggt tccagcccca 960 gcctggcggg gtgagcactg accttgtcgc agtgcgcaca gaggttccca gtggctactt 1020 gggaggaggc cagagggagg gtcgccgcag agctggggat ttgagggggc gggggtccga 1080 gcagggggct tacgttgaaa gctggccctc acagggcagg tgggtgctgg actggccttg 1140 gaggctgggg cctgggctca cggagcccca cctgggggct gtcatccctg tgcggcctgg 1200 cctgggcccc tatgggtctg ggggctgccc cctctctctg gacctctgtt gggtctggat 1260 gcgtgaggtt gggggaacct cccagggcct cctagctgct cccatcacca aaaactgacg 1320 tcagggttta agcttggtgg gtagcagtgc ctgggcctgg gcagtgaccc tgagcaggtg 1380 ttaactaggg gccgagggcg gggaaggtgt cagggcctgg ctgaggcctc aggaatgtcg 1440 tgtgtctcct ggaacctgct ccgagatctg ggggccccag tatggaaaca ggctcagggc 1500 tgtgacctcc tgcccggcag gacctgagtg tgagggtctg tcccacactg acaccctttc 1560 tgctcctcct agaaccgtac ggagtcccca gaacctaatg ccacagcgac ccctgcgatc 1620 cccactatcc tggtgacctc tgtgacctct gagaccccag caacaagtgc tccagaggca 1680 gagggacccc aaagtggggg gctcccgccc ccgcccaggg cagttccctc gagcagtagc 1740 ccccaggccc aaggtgggtc aggtgggcct gggaggaggt gtcgtgcttc accttagggc 1800 tgggtgggag gagcatggct gcggctggag gtcctgaggg gctcgggtgc ccctcgaggg 1860 agccctgacc ctgccacccc ctccccacag cactcaccga ggacgggagg ccctgcaggt 1920 tccccttccg ctacgggggc cgcatgctgc atgcctgcac ttcggagggc agtgcacaca 1980 ggaagtggtg ggtccgggca gccggggcac ccgagctggg gtcacctgcc ccacgctgcc 2040 tgcttttctg ggagccgggc acacagtagg cgctcaccac gcagcaggcg gacccagtga 2100 acccagagac cctccagggt ggtggggtgg ggtggggggc ctctgcctgg gacccccatg 2160 cacgcaggtg tcgcccccca ggtgtgccac aactcacaac tacgaccggg acagggcctg 2220 gggctactgt gtggaggcca ccccgcctcc agggggccca ggtgggtgct gggttgggta 2280 gcctggggcg agcagggggc actgggccag gccagaaggg ccaaggggag gatggggcgg 2340 acccgggcag gggtcctggc tggaggggag cagaagagga gctctgggat taaccccggt 2400 gggtgccact tagggccaga gcctctccca ggtgggacct gcgtctcatg gtgcgtgcgc 2460 ggccatcgct ggggccaagg cgccgcctgg tggtgaggcc gggccctgca gccacacagg 2520 cgtgccccag gcaggggaca ggtgggcagg gtctgtgggg tgcggtgcca gccgccctgc 2580 tcacatgggt cctgggacac atgggagggg tctgctgcct gacagtgtgg gtgtcaggct 2640 tccaggaagc cacgtgcaca gctgggccag tggcccaggt gttgagtggg ggacgctggg 2700 aggaagggga ggtctgtgcc cctcccaggg accttgcacc ccgaggggcg tagagagggc 2760 ccctttgctc tcagagcccc tcactgacct gatggacgcc ttagcaagca gagaatgtca 2820 cagagggacc ctgagcctcc cagtccgccc ctcacatccc ctcccgcatg tccccagctg 2880 ccctggatcc ctgtgcctcc ggcccctgcc tcaatggagg ctcctgctcc aatacccagg 2940 acccccagtc ctatcactgc agctgccccc gggccttcac cggcaaggac tgcggcacag 3000 gtgagctggg cccggaggtc cgcagggtcc aggggccgga gcaagtcccg gaggatggga 3060 gaacaggtgg ctcccgagtg cagggcaggg gccctgcacg gggacagcag gtggcagggt 3120 gtgagggctt actgtgcacc cctcagagaa atgctttgat gagacccgct acgagtacct 3180 ggaggggggc gaccgctggg cccgcgtgcg ccagggccac gtggaacagt gcgagtgctt 3240 cgggggccgg acctggtgcg aaggcacccg acatacaggt gcgccacggg gtgtgagccg 3300 tgccactgac ccctgacggg tgtccctgtc cacacccgag tgggaggaat ggcctgaggt 3360 cacccagaaa caagggacaa ggggtggacc ccggccccga ctccgctgtc gtggggcact 3420 gcgcggcccc tggcccagct cctcggccct gcccccagct tgtctgagca gcccttgcct 3480 gaacgggggc acctgccacc tgatcgtggc caccgggacc accgtgtgtg cctgcccacc 3540 aggcttcgct ggacggctct gcaacatcgg tgagtgggtc agccccccgg ggtgccctgg 3600 ggcagtgccg ggtggaccca ccgtgggccg gcctcactgc ccctctgccc gcagagcctg 3660 atgagcgctg cttcttgggg aacggcactg ggtaccgtgg cgtggccagc acctcagcct 3720 cgggcctcag ctgcctggcc tggaactccg atctgctcta ccaggagctg cacgtggact 3780 ccgtgggcgc cgcggccctg ctgggcctgg gcccccatgc ctactgccgg tcagcaccaa 3840 cgccgctcca ggccgccgca cgcggggcag gcaggatttt tcctggtgag aggccccccg 3900 gctccctagg acccaggcgg ggccatctcc gtccagacag gccccggaac ctctgcctgg 3960 gaggctgccc gagggagggc cactctcttc ccgctgctcc aggtgcgggg aaccgccctg 4020 ctgggggttc cgatgccccc tccccatgcc ctcttcgagg ggcagtgtga ctccctgcca 4080 gcccccactt atgcaccgca ggaatccgga caatgacgag aggccctggt gctacgtggt 4140 gaaggacagc gcgctctcct gggagtactg ccgcctggag gcctgcggtg cgcggctggc 4200 ggggggtgct gccttgggcc ccaccgaggt cacagcagtt ttccccgtga tcctcctagc 4260 ccctctgcac acctggctac tgcatctctg acaaatgggg aaactggagc tcacgggatc 4320 aggctggtcc aaggtcacgc agtgggtcgg tactggggtc acagtgggga agcagcccgc 4380 tgcagggggc tggtcaccag gcgacggcct cggggtggca cctgcccagc ctggaccatg 4440 cccaggatgg ccgcagaagc ctttcaggga ggtgcaggga gggcagcgtg caggcccccc 4500 agaggccacc tgcttcctgc cctggggaga ggccccccgg ctccctagga ccccggcggg 4560 gccacccggg gctctcatgt gggggtctct gactgtgctg gggctggctg tggggttccg 4620 ggctgctgag ggggccacaa aggcctccgt gtgtccagcc cctctggccc tcacagagcc 4680 tcgggatcgg gcatcaaacc ccattctaca gatttggaaa ctgagggcag aggtgagtgg 4740 gcgccagggc ctgagcagcg tggacagggg gtccggccat ggccctctgc agcgcctcct 4800 gccgggtagg gcctgtgtgt ggaagggggc tggccctgtg aaccccaggg gtgtgacccg 4860 gtgacctttg ctcccagaat ccctcaccag agtccaactg tcaccggatc tcctggcgac 4920 cctgcctgag ccagcctccc cggggcgcca ggcctgcggc aggaggcaca agaagaggac 4980 gttcctgcgg ccacgtatca tcggcggctc ctcctcgctg cccggctcgc acccctggct 5040 ggccgccatc tacatcgggg acagcttctg cgccgggagc ctggtccaca cctgctgggt 5100 ggtgtcggcc gcccactgct tctcccacag gtgcacctcc tctgggcccc agtcacctgc 5160 cctgaggccc cacacaccat ccagcgtcac tatgcgcctg tccccacccg cttgcggacc 5220 ccatcccggt gcctctgctg accccttccc ggggtccccg gtaaccctct ctgacccctc 5280 tgggtcttgg ggctcagtcc tgagctgggc atgcatggac actccagaaa ccctgtccct 5340 attgagggag gccaggggtc agtggcattt ccacagagga cccagcgcct gcggagagtg 5400 cagtgggcca ggtcctgtcc tccccgcagc cccgcccctc ccagagtcct ggctctcagt 5460 agggagccag ggagcgcagt acaatgcgtc agagccctag gagcccaagc acagccaggg 5520 aaactgaggc ccagcccact cagccggctc ccctcagtgg gggcgcacag ccacccaggc 5580 ccacactctg ggaggcgggc ctcgagtggg gagaccctga gacggagcag cctgggccag 5640 acgcccttcc accttcgatg ggcaccccag tgattagggg caggggtccg gccagccgag 5700 ggtctggcgg cctttcgagg accacagctc ccagggtggg gtcctgcgtg gccctgcaga 5760 acctgcagcc gacgtctcct gggcctgcaa atggggccag agccttcctc agtgtggaga 5820 aatggggttc cccacatgga gcccagggca ggaggccgag gcagggtgga gcgacctcca 5880 cacagcagat gggagccagg ctcaggggcc caggctctgt gcccagcagg agtgagggct 5940 gcatctgggg accccacaat gtggatggaa gctggggcag ggcctgagca ggccaggtct 6000 ccacccactc gggtcggcct tgcagccgat cctgcctggg cttggcctga gactcccccc 6060 agggcttgtg accagtgttg tcaggaggga tggcaccgca cttcagctcc catgcctgga 6120 tctgggggtg actggcaata gcccctgctt ggtggtccct gtctccccag tatcaacagc 6180 ccacacccag gcacctgctc agacccctcc ccgggaccag ggtcccacac cattggcctc 6240 cgtgggcctg acagggggtg gggagaggtg agcccggtgg ctgggggagg gctggtccat 6300 gcagcctcca gccccccttg cacagccccc ccagggacag cgtctccgtg gtgctgggcc 6360 agcacttctt caaccgcacg acggacgtga cgcagacctt cggcatcgag aagtacatcc 6420 cgtacaccct gtactcggtg ttcaacccca gcgaccacga cctcggtgag ctccggcgtg 6480 tcgtggctgc actctgggca ggtgggccct gtgctcccca ggccaggccc agacaggggc 6540 aggagctggg cagacatgtg gtgcggggga agctgggggc agggcaggga ggacagggac 6600 cgtcccttct ggatctccca ggctgccctg tggaccccac tggctaccct ccctccacca 6660 cgggccccga cagcctcccg ttcagcccgc acaccacagg ctgaccctgg ccactcttct 6720 gatcagtcct gatccggctg aagaagaaag gggaccgctg tgccacacgc tcgcagttcg 6780 tgcagcccat ctgcctgccc gagcccggca gcaccttccc cgcaggacac aagtgccaga 6840 ttgcgggctg gggccacttg gatgagagtg agttgggagg ggggcgccca gcgtccgcca 6900 ggtggacagg tggccagcca cagtgtggtg tcacgctgag ggcattgtgt ccacagacgt 6960 gagcggctac tccagctccc tgcgggaggc cctggtcccc ctggtcgccg accacaagtg 7020 cagcagccct gaggtctacg gcgccgacat cagccccaac atgctctgtg ccggctactt 7080 cgactgcaag tccgacgcct gccaggtgag ctggtgcccg ccccaccagg acccgactgg 7140 tgggggctca gctggtcctg agtctccgag atgcttgccc ctggggagcc cagagcctgg 7200 cggcacccca acctggcagg gccagccagg gacccctggg cagggagcac acttactgtc 7260 ggtggccagg caccccaggg ccacccagag ccctgccgga agggcatcct cctcacacag 7320 aaggggagac ccaggctctg agaggggcct ggggtcccac agagcccgga cagttcctgg 7380 ctgtccagcc caaggcagtg ctttccgtgt gacactaggc accaaaggcc cctttgcccc 7440 gagttctctc aagccagctc ttcaaccttc aataagttct tcaaccttca ataagcccaa 7500 cagcccaacc acgtcctggg ctctgcagcc tgtgtgctca gcgcacgcac ctgcatgcga 7560 cggctctctt atgccccatt tatagctggg gagactgagc cccaggcagt caattcactc 7620 ttccaaggcc acaaagccca ggagtggtag agtgggtagg gcttgtcact ggacctcgat 7680 aagggaagtc aggatggttt cctggaggag ggagtgtttg cactggtcct gagtgatgcg 7740 taggagtttt ccagggagtg aagaagtcat ttcaggaggt gctgggacac agggtggctg 7800 tgtggtccac acagggttca tgctggtggg gagaggggga ccgtggcttc aggaagggga 7860 ataacgtggt tggatgccct ggcccagcca gtgctgcccc cagggaatga gacacctttt 7920 catgaggttc aggagagtgg atcagctccc ttgctcagaa atgcctttgt cctctgtccc 7980 caagctgcca cttggggtag aggggtgtcc ctgaaccagg cccctgggag ggtggctctg 8040 accaacgtct ctgcccaggg ggactcaggg gggcccctgg cctgcgagaa gaacggcgtg 8100 gcttacctct acggcatcat cagctggggt gacggctgcg ggcggctcca caagccgggg 8160 gtctacaccc gcgtggccaa ctatgtggac tggatcaacg accggatacg gcctcccagg 8220 cggcttgtgg ctccctcctg accctccagc gggacaccct ggttcccacc attccctgcc 8280 ttgctgacaa taaagatatt tccaagaacc cggcccacgc tg 8322 <210> 34 <211> 2576 <212> DNA <213> Homo sapiens <220> <223> Genbank Accession No. L04751 <400> 34 gaattccgca gagatccagc aggtgctgca ccatgagtgt ctctgtgctg agccccagca 60 gactcctggg tgatgtctct ggaatcctcc aagcggcctc cctgctcatt ctgcttctgc 120 tgctgatcaa ggcagttcag ctctacctgc acaggcagtg gctgctcaaa gccctccagc 180 agttcccgtg ccctccctcc cactggctct tcgggcacat ccaggagctc caacaggacc 240 aggagctaca acggattcag aaatgggtgg agacattccc aagtgcctgt cctcattggc 300 tatggggagg caaagttcgt gtccagctct atgaccctga ctatatgaag gtgattctgg 360 ggagatcaga cccgaaatcc catggttcct acagattcct ggctccatgg attgggtacg 420 gcttgctcct gttgaatggg cagacatggt tccagcatcg acggatgctg accccagcct 480 tccactatga catcctgaag ccctatgtgg ggctcatggc agactctgta cgagtgatgc 540 tggacaaatg ggaagagctc cttggccagg attcccctct ggaggtcttt cagcacgtct 600 ccttgatgac cctggacacc atcatgaagt gtgccttcag ccatcagggc agcatccagg 660 tggacaggaa ttctcagtcc tacatacagg ccattagtga cctgaacaac ctggtttttt 720 cccgtgtgag gaatgccttt caccagaatg acaccatcta cagcctgacc tctgctggcc 780 gctggacaca ccgcgcctgc cagctggccc atcagcacac agaccaagtg atccaactga 840 ggaaggctca actacagaag gagggggagc tggagaagat caagaggaag aggcatttgg 900 attttctgga tatcctcctc ttggccaaaa tggagaatgg gagcatcttg tcagacaagg 960 acctccgtgc tgaggtggac acgttcatgt ttgagggcca cgacaccaca gccagtggga 1020 tctcctggat cctctatgct ctggccacac accccaagca tcaggagagg tgccgggagg 1080 agatccacag cctcctgggt gatggagcct ccatcacctg gaaccacctg gaccagatgc 1140 cctacaccac catgtgcatt aaggaggcac tgaggctcta cccaccggtg ccaggcattg 1200 gcagagagct cagcactccc gtcaccttcc ctgatgggcg ctccttgccc aaaggtatca 1260 tggtcctcct ctccatttat ggccttcacc acaacccaaa agtgtggccc aacccagagg 1320 tgtttgaccc tttccgtttt gcaccgggtt ctgctcaaca cagccacgct ttcctgccct 1380 tctcaggagg atcaaggaac tgcattggga aacaatttgc catgaacgag ctgaaggtgg 1440 ccacggccct gaccctgctc cgctttgagc tgctgcctga tcccaccagg atccccatcc 1500 ccattgcacg acttgtgttg aaatccaaaa atggaatcca cctgcgtctc aggaggctcc 1560 ctaacccttg tgaagacaag gaccagcttt gagggcctcc acctgccgtc ctgtcttcct 1620 gacccccgct tctgtcccct tcctgtctgc ccatatcctg ttttctgtct gcccaccttc 1680 ccttcttccc acctgcctgc tgtcccccag tctgcctgcc cttctctctc tcacctttct 1740 ccaggctccc tacctgcttg tctacctgtc tcctacccac ctgtatctct tgttgggaga 1800 aaagctgagt gttgggagaa gctgaggccg agcttgcatg tctgacataa tgtaaaagag 1860 tcttgaatca tgtccaggat ccagggtcta aaaccccttg tggcctttgg aacaccaagc 1920 tctgtgctga agggtggaag gctaccctga cgcaccataa tctaagcccg gggcataaaa 1980 cccctcgtgg cttggataga atccagggct cgtggctctg gaatgtgtct ggacttgctg 2040 gctccttgct ccttgctctc ccaggatcaa ttgtatcttg agttaaaaga acctgctctc 2100 cattatctca agtaacagag cagatgctaa accgtcacag ctgtaaattg tgtgcttaat 2160 gcaacatgcc ctttcgaccc accccccatt ctcaccacct gtttctttgt ttgatcacca 2220 ataaataatc tgcacttcca gagctcgggg ccttcacagc ctccatcctt agctttggcg 2280 ccctggaccc actttctctc tcaaactgtc ttttctcact gctttgactc tgccggactt 2340 tgtcaccccc acgacctggt gttgggtctg aacaccccaa catccctgaa tctccaccca 2400 cctcccaaac tcctgcctgc cctccagact gtctgcccat acacctgtct ccttcttcct 2460 gcctggcttg tctgttccta tattagtttc ctattactgc tgtaataaac tatcacaatc 2520 tcagtgattt taaataaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaacg gaattc 2576 <210> 35 <211> 1719 <212> DNA <213> Homo sapiens <220> <223> Genbank Accession No. L27050 <400> 35 caaacacata caggaagcga tcaaacctac caaggcagtc tcacttctca atgactggac 60 tgtgtgggta ctctgctcca gacatgcgtg gcctcagact catcatgata ccagttgagc 120 tgctactttg ctacctcctg ctgcaccctg tggatgccac ttcatatgga aagcagacaa 180 atgtcttgat gcactttccc ttgtccttgg aatcccagac accctcctca gaccccttgt 240 cctgccaatt tctgcaccca aagtcactgc ctggtttcag ccacatggcc cctctaccca 300 agttcttggt aagcctggct ctaaggaatg ccctggagga agctggttgt caggctgatg 360 tttgggctct acagctacag ctctaccgcc agggtggtgt gaatgctaca caggtcctca 420 tccagcatct tcgagggctc cagaaaggca gaagcacaga gaggaacgtg tcagtggaag 480 ccctggcctc tgctctgcag ctgttagcca gggagcagca aagcacagga agggtcgggc 540 gctccctccc gacagaggac tgtgagaatg agaaggagca agctgtgcac aatgtagtcc 600 agctgctgcc aggagtggga accttctaca acctgggcac agctttgtat tatgctactc 660 aaaactgcct gggcaaggcc agggaacgag gccgagatgg ggccatagat ctgggatatg 720 accttctgat gaccatggct gggatgtcag gggggcctat gggtctagcg atcagtgctg 780 cacttaaacc tgcattaagg tctggggttc agcagttgat ccagtattac caagatcaga 840 aagacgcaaa catctctcag ccggagacca ccaaggaggg tttgagggcc atctcagatg 900 tgagtgactt ggaagaaaca actactctgg cttctttcat atcagaagta gtaagttcag 960 ctccctactg ggggtgggcc ataatcaaga gctatgactt agatcctggg gctgggagtc 1020 ttgagatata aaagaatgtg gtaaccacag aattaataac tgtctaccct gacaagctat 1080 atacatgtct tcaaaatttt aatctgattt atccaggagg aaggctgtac agtaaaacgt 1140 aagaacgtaa atgtttgggt gttgaagtca cagggtttgg tttcgaatct aggctccact 1200 tgttagagcc tcggtgatca ctgaatagta acttctttct tgaactaaga tcagttttga 1260 agtttctaaa ggagatagaa tgattttaac ctcaatgagt tgccctgtaa atttaaaatg 1320 atacaatgaa tctaaaatgc ttatcacagt actttcaata aatagctatt agccaggtgc 1380 ggtggctcac gcctgtaatc ccagcactgt gagaggctga ggcgggatga tcacctgagg 1440 tcaggagttc aagatcagcc tgcgcaacat ggcgaaaccc cgtctctaca ataaatagca 1500 aaaaattatc ctggcggagt tatgcacgct tgtagtccca actacctggg aggctgaggc 1560 gggagaatca cctgagcctg ggaggctgag gcgggagaat cacctgagcc tgggaggtcg 1620 aggctgcagc gagccgagat cgcgccgctg cattccagcc tgggtgacag agcgagacca 1680 tgtctcaaaa aataaaaata aaaaaaaatt gttttcatt 1719 <210> 36 <211> 1337 <212> DNA <213> Homo sapiens <220> <223> Genbank Accession No. U37100 <400> 36 caaaaacagc aacagaaagc aggacgtgag acttctacct gctcactcag aatcatttct 60 gcaccaacca tggccacgtt tgtggagctc agtaccaaag ccaagatgcc cattgtgggc 120 ctgggcactt ggaagtctcc tctcggcaaa gtgaaagaag cagtgaaggt ggccattgat 180 gcaggatatc ggcacattga ctgtgcctat gtctatcaga atgaacatga agtgggggaa 240 gccatccaag agaagatcca agagaaggct gtgaagcggg aggacctgtt catcgtcagc 300 aagttgtggc ccactttctt tgagagaccc cttgtgagga aagcctttga gaagaccctc 360 aaggacctga agctgagcta tctggacgtc tatcttattc actggccaca gggattcaag 420 tctggggatg accttttccc caaagatgat aaaggtaatg ccatcggtgg aaaagcaacg 480 ttcttggatg cctgggaggc catggaggag ctggtggatg aggggctggt gaaagccctt 540 ggggtctcca atttcagcca cttccagatc gagaagctct tgaacaaacc tggactgaaa 600 tataaaccag tgactaacca ggttgagtgt cacccatacc tcacgcagga gaaactgatc 660 cagtactgcc actccaaggg catcaccgtt acggcctaca gccccctggg ctctccggat 720 agaccttggg ccaagccaga agacccttcc ctgctggagg atcccaagat taaggagatt 780 gctgcaaagc acaaaaaaac cgcagcccag gttctgatcc gtttccatat ccagaggaat 840 gtgattgtca tccccaagtc tgtgacacca gcacgcattg ttgagaacat tcaggtcttt 900 gactttaaat tgagtgatga ggagatggca accatactca gcttcaacag aaactggagg 960 gcctgtaacg tgttgcaatc ctctcatttg gaagactatc ccttcgatgc agaatattga 1020 ggttgaatct cctggtgaga ttatacagga gattctcttt cttcgctgaa gtgtgactac 1080 ctccactcat gtcccatttt agccaagctt atttaagatc acagtgaact tagtcctgtt 1140 atagacgaga atcgaggtgc tgttttagac atttatttct gtatgttcaa ctaggatcag 1200 aatatcacag aaaagcatgg cttgaataag gaaatgacaa ttttttccac ttatctgatc 1260 agaacaaatg tttattaagc atcagaaact ctgccaacac tgaggatgta aagatcaata 1320 aaaaaaataa taatcat 1337 <210> 37 <211> 1517 <212> DNA <213> Homo sapiens <220> <223> Genbank Accession No. U02390 <400> 37 attctttggg gaggcaacta ggatggtgtg gccgaccacg gatttgcatt gccgaggacg 60 ggaccccagg gcagcgaagc agaatggcca acatgcaggg actggtggaa agactggaac 120 gagctgtcag ccgcctggag tcgctgtctg cagagtccca caggccccct gggaactgcg 180 gggaagtcaa tggtgtcatt gcaggtgtgg caccctccgt ggaagccttt gacaagctga 240 tggacagtat ggtggccgag tttttaaaga acagtaggat ccttgctggg gacgtggaga 300 cccatgcaga aatggtgcac agtgctttcc aggcccagcg ggctttcctt ctgatggcct 360 ctcagtacca acaaccccac gagaatgacg tggccgcact tctgaaaccc atatcggaaa 420 agattcagga aatccaaact ttcagagaga gaaaccgggg gagtaacatg tttaatcatc 480 tttcggccgt cagcgaaagc atccctgccc ttggatggat agctgtgtct cccaaacctg 540 gtccttatgt caaggagatg aatgacgctg ccacctttta cactaacagg gtcttaaagg 600 actacaaaca cagtgatttg cgtcatgtgg attgggtgaa gtcatatttg aacatttgga 660 gtgaacttca agcatacatc aaggaacacc acaccacggg cctcacatgg agcaaaacag 720 gtcctgtagc atccacagta tcagcgtttt ctgtcctctc ctctgggcct ggccttcctc 780 caccccctcc tcctctgcct cctccagggc cacctccact tttcgagaat gaaggcaaaa 840 aagaggaatc ttctccttca cgctcagctt tatttgccca acttaaccag ggagaagcaa 900 ttacaaaagg gctccgccat gtcacagatg accagaagac atacaaaaat cccagcctgc 960 gggctcaagg agggcaaact caatctccca ccaaaagtca cactccaagt cccacatctc 1020 ctaaatctta tccttctcaa aaacatgccc cagtgttgga gttggaagga aagaaatgga 1080 gagtggagta ccaagaggac aggaatgacc ttgtgatttc agagactgag ctgaaacaag 1140 tggcttacat tttcaaatgc gaaaaatcaa ctattcagat aaaagggaaa gtaaactcca 1200 ttataattga caactgtaag aaactcggcc tggtgtttga caatgtggtg ggcattgtgg 1260 aagtgatcaa ctcccaggac attcaaatcc aggtaatggg gagagtgcca acaatttcca 1320 ttaataagac agaaggttgc cacatatacc tcagtgaaga tgcattagac tgtgagatcg 1380 tgagcgccaa gtcatctgaa atgaacatac ttatccctca ggatggtgat tatagagaat 1440 ttcccattcc tgaacagttc aagacagcat gggatggatc caagttaatc actgaacctg 1500 cagaaattat ggcctaa 1517 <210> 38 <211> 536 <212> DNA <213> Homo sapiens <220> <223> Genbank Accession No. AW006831 <400> 38 tttttctgga attctttttt tttttttttt ttttgaggat tttgtgtggc taatgtgttc 60 tagaagcaga gactccaggg agaaccagaa tttatgaagc ctcgtgcaac atggtgcttt 120 ctcaccgagg tcatatgcct ggctgctgct gttccactca gctccatgag ccacgtttgt 180 tattttatgt ttcttctgtg cttttgctca tttccaccca tgtgtttata gacctttttt 240 cagccctttt tctttgttcc tttccctcat ctttttgcct caggtagaat ccatcagttt 300 tcctccccct ccaaatgact gtgtacctcc agctgctcag gactttggag gtgggggcgg 360 ggcctgggga tctacccttc taaaaaactc tccaagtaat tctgatacca ataaagtggg 420 agacctccat ttttgaggcc tatttgcaag catgtctccc tccctttcca tggctttttc 480 gtttctcgca tgttccactg ctttgcactg tctagacagg aaacctagga agatgt 536 <210> 39 <211> 2194 <212> DNA <213> Homo sapiens <220> <223> Genbank Accession No. U90441 <400> 39 ggggaaggaa cactgtaggg gatagctgtc cacggacgct gtctacaaga ccctggagtg 60 agataacgtg cctggtactg tgccctgcat gtgtaagatg cccagttgac cttcgcagca 120 ggagcctgga tcaggcactt cctgcctcag gtattgctgg acagcccaga cacttccctc 180 tgtgaccatg aaactctggg tgtctgcatt gctgatggcc tggtttggtg tcctgagctg 240 tgtgcaggcc gaattcttca cctctattgg gcacatgact gacctgattt atgcagagaa 300 agagctggtg cagtctctga aagagtacat ccttgtggag gaagccaagc tttccaagat 360 taagagctgg gccaacaaaa tggaagcctt gactagcaag tcagctgctg atgctgaggg 420 ctacctggct caccctgtga atgcctacaa actggtgaag cggctaaaca cagactggcc 480 tgcgctggag gaccttgtcc tgcaggactc agctgcaggt tttatcgcca acctctctgt 540 gcagcggcag ttcttcccca ctgatgagga cgagatagga gctgccaaag ccctgatgag 600 acttcaggac acatacaggc tggacccagg cacaatttcc agaggggaac ttccaggaac 660 caagtaccag gcaatgctga gtgtggatga ctgctttggg atgggccgct cggcctacaa 720 tgaaggggac tattatcata cggtgttgtg gatggagcag gtgctaaagc agcttgatgc 780 cggggaggag gccaccacaa ccaagtcaca ggtgctggac tacctcagct atgctgtctt 840 ccagttgggt gatctgcacc gtgccctgga gctcacccgc cgcctgctct cccttgaccc 900 aagccacgaa cgagctggag ggaatctgcg gtactttgag cagttattgg aggaagagag 960 agaaaaaacg ttaacaaatc agacagaagc tgagctagca accccagaag gcatctatga 1020 gaggcctgtg gactacctgc ctgagaggga tgtttacgag agcctctgtc gtggggaggg 1080 tgtcaaactg acaccccgta gacagaagag gcttttctgt aggtaccacc atggcaacag 1140 ggccccacag ctgctcattg cccccttcaa agaggaggac gagtgggaca gcccgcacat 1200 cgtcaggtac tacgatgtca tgtctgatga ggaaatcgag aggatcaagg agatcgcaaa 1260 acctaaactt gcacgagcca ccgttcgtga tcccaagaca ggagtcctca ctgtcgccag 1320 ctaccgggtt tccaaaagct cctggctaga ggaagatgat gaccctgttg tggcccgagt 1380 aaatcgtcgg atgcagcata tcacagggtt aacagtaaag actgcagaat tgttacaggt 1440 tgcaaattat ggagtgggag gacagtatga accgcacttc gacttctcta ggaatgatga 1500 gcgagatact ttcaagcatt tagggacggg gaatcgtgtg gctactttct taaactacat 1560 gagtgatgta gaagctggtg gtgccaccgt cttccctgat ctgggggctg caatttggcc 1620 taagaagggt acagctgtgt tctggtacaa cctcttgcgg agcggggaag gtgactaccg 1680 aacaagacat gctgcctgcc ctgtgcttgt gggctgcaag tgggtctcca ataagtggtt 1740 ccatgaacga ggacaggagt tcttgagacc ttgtggatca acagaagttg actgacatcc 1800 ttttctgtcc ttccccttcc tggtccttca gcccatgtca acgtgacaga cacctttgta 1860 tgttccttgt atgttcctat caggctgatt tttggagaaa tgaatgtttg tctggagcag 1920 agggagacca tactagggcg actcctgtgt gactgaagtc ccagcccttc cattcagcct 1980 gtgccatccc tggccccaag gctaggatca aagtggctgc agcagagtta gctgtctagc 2040 gcctagcaag gtgcctttgt acctcaggtg ttttaggtgt gagatgtttc agtgaaccaa 2100 agttctgata ccttgtttac atgtttgttt ttatggcatt tctatctatt gtggctttac 2160 caaaaaataa aatgtcccta ccagaagcct taaa 2194 <210> 40 <211> 1324 <212> DNA <213> Homo sapiens <220> <223> Genbank Accession No. D43642 <400> 40 ctggtgaggg gctgcaggtg gcggcgcagt ctcggtaggc ggtatgagtt tggctggggg 60 ccgggcaccc cggaagaccg ctgggaaccg gctttctggg cttttggagg cagaggagga 120 agatgagttc taccagacga cttatggggg tttcacagag gaatccggag atgatgagta 180 tcaaggggac cagtcagaca cagaggacga agtggactct gactttgaca ttgatgaagg 240 ggatgaacca tccagtgatg gagaagcaga agagccaaga aggaagcgcc gagtagtcac 300 caaggcctat aaggaacctc tcaagagctt aaggcctcga aaggtcaaca ccccggctgg 360 tagctctcag aaggcgcgag aagagaaggc actactgcca ttagaactac aagatgacgg 420 ctctgacagt cggaagtcta tgcgtcagtc tacagctgag catacacgac aaacgttcct 480 tcgggtacag gagaggcagg gccagtcaag acggcgaaag gggccccact gtgagcggcc 540 actaacccag gaggaactgc tccgggaggc caagatcaca gaagagctta atttacggtc 600 actggagaca tatgagcggc tcgaggctga taaaaagaag caggttcata agaagcggaa 660 gtgccccggg cccataatca cctatcattc agtgacagtg ccacttgttg gggagccagg 720 ccccaaggaa gagaacgttg acatagaagg acttgatcct gctccctcgg tgtctgcatt 780 gactcctcat gctgggactg gacccgtcaa cccccctgct cgctgctcac gtaccttcat 840 cacttttagt gatgatgcaa ctttcgagga atggttcccc caagggcggc ccccaaaagt 900 ccctgttcgt gaggtctgtc cagtgaccca tcgtccagcc ctataccggg accctgttac 960 agacataccc tatgccactg ctcgagcctt caagatcatt cgtgaggctt acaagaagta 1020 cattactgcc catggactgc cgcccactgc ctcagccctg ggccccggcc cgccacctcc 1080 tgagcccctc cctggctctg ggccccgagc cttgcgccag aaaattgtca ttaaatgaag 1140 agatgtctag tcctcagaaa cttctttcct gccctgattg gggctcttgc tgttccgttt 1200 cttctccctg cttctcccct ttgtcatctc tgatctttgc ctaatctgtt tctttttcct 1260 tttcccctag ttcttacagg tttcgttgtg ttttttaatc taataaaata gaaagatccc 1320 tttt 1324 <210> 41 <211> 890 <212> DNA <213> Homo sapiens <220> <223> Genbank Accession No. M91670 <400> 41 ggcggaccga agaacgcagg aagggggccg gggggacccg cccccggccg gccgcagcca 60 tgaactccaa cgtggagaac ctacccccgc acatcatccg cctggtgtac aaggaggtga 120 cgacactgac cgcagaccca cccgatggca tcaaggtctt tcccaacgag gaggacctca 180 ccgacctcca ggtcaccatc gagggccctg aggggacccc atatgctgga ggtctgttcc 240 gcatgaaact cctgctgggg aaggacttcc ctgcctcccc acccaagggc tacttcctga 300 ccaagatctt ccacccgaac gtgggcgcca atggcgagat ctgcgtcaac gtgctcaaga 360 gggactggac ggctgagctg ggcatccgac acgtactgct gaccatcaag tgcctgctga 420 tccaccctaa ccccgagtct gcactcaacg aggaggcggg ccgcctgctc ttggagaact 480 acgaggagta tgcggctcgg gcccgtctgc tcacagagat ccacgggggc gccggcgggc 540 ccagcggcag ggccgaagcc ggtcgggccc tggccagtgg cactgaagct tcctccaccg 600 accctggggc cccagggggc ccgggagggg ctgagggtcc catggccaag aagcatgctg 660 gcgagcgcga taagaagctg gcggccaaga aaaagacgga caagaagcgg gcgctgcggg 720 cgctgcggcg gctgtagtgg gctctcttcc tccttccacc gtgaccccaa cctctcctgt 780 cccctccctc caactctgtc tctaagttat ttaaattatg gctggggtcg gggagggtac 840 agggggcact gggacctgga tttgtttttc taaataaagt tggaaaagca 890 <210> 42 <211> 457 <212> DNA <213> Homo sapiens <220> <223> Genbank Accession No. AI478190 <220> <221> unsure <222> (1)..(457) <223> n = a or c or g or t <400> 42 tttttttttt tttttttttt tttttttttt tggggattta tatgactttt attttaatat 60 cattttaata tcgaatatgt cacaagattt aatgaccaaa ttagtcattt acatttttca 120 aagtatctaa atataaaatt gctaaaaatt caaatacaga tagcaagcta caaatatttc 180 ttttgttttt gggggggggg taggaatgga agacattaaa aaaggacgct cctgttggct 240 gaacaaagat cagaatgaaa gaagaattca tcagcntgac cccttgtgca aagaaataca 300 ctcagcttta agatgctgtt ttagacacat ctcttcctgt acaacaattt aaaaaatgtt 360 tctaatgcag gtcctcagtg aaacacccct ctccctgaaa cgtgagaaac agcagctttc 420 cgcctgcttg aaaaaggagg caggcgctgt aaggaga 457 <210> 43 <211> 1330 <212> DNA <213> Homo sapiens <220> <223> Genbank Accession No. U51007 <400> 43 aattcccaaa tgacctttta tttcatacag agatacaaag gcaactatgt gcagcaacaa 60 tctgatgggc agtccaaact cttgggagga agtaaattca tggtaaatgt catgatggcg 120 gtcgggaggg aggaaggtgg caagatggtg ttggaaagca ctatggtgtg tgtggacaac 180 agtgagtata tgcggaatgg agacttctta cccaccaggc tgcaggccca gcaggatgct 240 gtcaacatag tttgtcattc aaagacccgc agcaaccctg agaacaacgt gggccttatc 300 acactggcta atgactgtga agtgctgacc acactcaccc cagacactgg ccgtatcctg 360 tccaagctac atactgtcca acccaagggc aagatcacct tctgcacggg catccgcgtg 420 gcccatctgg ctctgaagca ccgacaaggc aagaatcaca agatgcgcat cattgccttt 480 gtgggaagcc cagtggagga caatgagaag gatctggtga aactggctaa acgcctcaag 540 aaggagaaag taaatgttga cattatcaat tttggggaag aggaggtgaa cacagaaaag 600 ctgacagcct ttgtaaacac gttgaatggc aaagatggaa ccggttctca tctggtgaca 660 gtgcctcctg ggcccagttt ggctgatgct ctcatcagtt ctccgatttt ggctggtgaa 720 ggtggtgcca tgctgggtct tggtgccagt gactttgaat ttggagtaga tcccagtgct 780 gatcctgagc tggccttggc ccttcgtgta tctatggaag agcagcggca gcggcaggag 840 gaggaggccc ggcgggcagc tgcagcttct gctgctgagg ccgggattgc tacgactggg 900 actgaagact cagacgatgc cctgctgaag atgaccatca gccagcaaga gtttggccgc 960 actgggcttc ctgacctaag cagtatgact gaggaagagc agattgctta tgccatgcag 1020 atgtccctgc agggagcaga gtttggccag gcggaatcag cagacattga tgccagctca 1080 gctatggaca catccgagcc agccaaggag gaggatgatt acgacgtgat gcaggacccc 1140 gagttccttc agagtgtcct agagaacctc ccaggtgtgg atcccaacaa tgaagccatt 1200 cgaaatgcta tgggctccct ggcctcccag gccaccaagg acggcaagaa ggacaagaag 1260 gaggaagaca agaagtgaga ctggagggaa agggtagctg agtctgctta gggactgcat 1320 gggggaattc 1330 <210> 44 <211> 776 <212> DNA <213> Homo sapiens <220> <223> Genbank Accession No. AI953020 <220> <221> unsure <222> (1)..(776) <223> n = a or c or g or t <400> 44 gcggccgcca tctcgccgtc gtcccgcggg gtgcccgggg cgttgctcag gccggccacg 60 gcgccggggg aactcttcgg caacccgtcc atgtcgcccg agcccaggga tccgttcacg 120 tggtgaggct ccatcgcgct catggcggcc atggggccct ccgggccagg gccgagcggg 180 aaattagccc tgccggcgcc ctgcccgatg gggttcatga tagtgtacat gttttcgctg 240 gagttggtgg aatctccagg gctaggcatg atgggtgttc cagggggccc acctcctcct 300 gggggtccgg tgtagctgcc gggggatgag gaggagtagg ggatcgagtt tccactgggg 360 ctggcccacg ggccacgaac tcctgggccc atgttcatgg caggcaggcc tgggccggcg 420 agggagttgg gtgggggtcg catgccacct ccatagctct ggggccccac gctggccatg 480 ccacgaggag gcgtcaccct ctgcattgng ccgcccatgc tcggatgccc ctgggctcgt 540 ggggagggct ccatggcgcc agggaggagg ggctggggag ccaggaggcc tgcgggaggc 600 tgacnntcgc atccgcaggg tggccgnang cccnctgnga agcgcggtga catgaagggg 660 ctgggagagc cangccgcat ggagcctgcn gncattgtgt cacctggggc catactccnc 720 ataaccgggg ctgnggcggc tgcagcacta tagtnctgga aggncntggn ctcngc 776 <210> 45 <211> 476 <212> DNA <213> Homo sapiens <220> <223> Genbank Accession No. AI971969 <400> 45 tttttttttt gagctgactc tgtcccttta atgcccaggc tgagcccagt gcctccttga 60 gtatctgctc catcactggc gacgccacag gtaggtgtga atggagtagc caggtgagat 120 tgtctccagg aagcccacag caggatcctt gatggtaaga ggcacatcct tagaggagcg 180 gtttagcacg accacaacag cagagccatc gggatgcatc agtgccactg cgtccaggtc 240 gttcttctga ctggcaacca gccccactct ctgggagccc tcaggaatga acttgctgaa 300 gtggccaagg tggtagaaca tgggctgttt gtaaaacgtg tccttggtga tgtctacaat 360 gatgggactg tcgacaaagt tacgcaccca attgggtcct ccttcggggt tcagggcaag 420 gttccagtcg gtccagccga ccacatggta caggaggttt gttgatgaat gctgtg 476 <210> 46 <211> 2745 <212> DNA <213> Homo sapiens <220> <223> Genbank Accession No. AF046889 <400> 46 acaatcctcg ccttgtctgt ggcgccggca tctggagctt tctgtagcct ccggatacgc 60 ctttttttca gggcgtagcc cctagccaag ctgctccccg cggcggccgc acagcagccc 120 gagcgccccc tttccagagc tcccctccgg agctgggatc caggcgcgta gcggagatcc 180 caggatcctg ggtgctgttt gggcccgctc cccaccatga cctcctcggg gcctggaccc 240 cggttcctgc tgctgctgcc gctgctgctg ccccctgcgg cctcagcctc cgaccggccc 300 cggggccgag acccggtcaa cccagagaag ctgctggtga tcactgtggc cacagctgaa 360 accgaggggt acctgcgttt cctgcgctct gcggagttct tcaactacac tgtgcggacc 420 ctgggcctgg gagaggagtg gcgagggggt gatgtggctc gaacagttgg tggaggacag 480 aaggtccggt ggttaaagaa ggaaatggag aaatacgctg accgggagga tatgatcatc 540 atgtttgtgg atagctacga cgtgattctg gccggcagcc ccacagagct gctgaagaag 600 ttcgtccaga gtggcagccg cctgctcttc tctgcagaga gcttctgctg gcccgagtgg 660 gggctggcgg agcagtaccc tgaggtgggc acggggaagc gcttcctcaa ttctggtgga 720 ttcatcggtt ttgccaccac catccaccaa atcgtgcgcc agtggaagta caaggatgat 780 gacgacgacc agctgttcta cacacggctc tacctggacc caggactgag ggagaaactc 840 agccttaatc tggatcataa gtctcggatc tttcagaacc tcaacggggc tttagatgaa 900 gtggttttaa agtttgatcg gaaccgtgtg cgtatccgga acgtggccta cgacacgctc 960 cccattgtgg tccatggaaa cggtcccact aagctgcagc tcaactacct gggaaactac 1020 gtccccaatg gctggactcc tgagggaggc tgtggcttct gcaaccagga ccggaggaca 1080 ctcccggggg ggcagcctcc cccccgggtg tttctggccg tgtttgtgga acagcctact 1140 ccgtttctgc cccgcttcct gcagcggctg ctactcctgg actatccccc cgacagggtc 1200 acccttttcc tgcacaacaa cgaggtcttc catgaacccc acatcgctga ctcctggccg 1260 cagctccagg accacttctc agctgtgaag ctcgtggggc cggaggaggc tctgagccca 1320 ggcgaggcca gggacatggc catggacctg tgtcggcagg accccgagtg tgagttctac 1380 ttcagcctgg acgccgacgc tgtcctcacc aacctgcaga ccctgcgtat cctcattgag 1440 gagaacagga aggtgatcgc ccccatgctg tcccgccacg gcaagctgtg gtccaacttc 1500 tggggcgccc tgagccccga tgagtactac gcccgctccg aggactacgt ggagctggtg 1560 cagcggaagc gagtgggtgt gtggaatgta ccatacatct cccaggccta tgtgatccgg 1620 ggtgataccc tgcggatgga gctgccccag agggatgtgt tctcgggcag tgacacagac 1680 ccggacatgg ccttctgtaa gagctttcga gacaagggca tcttcctcca tctgagcaat 1740 cagcatgaat ttggccggct cctggccact tccagatacg acacggagca cctgcacccc 1800 gacctctggc agatcttcga caaccccgtc gactggaagg agcagtacat ccacgagaac 1860 tacagccggg ccctggaagg ggaaggaatc gtggagcagc catgcccgga cgtgtactgg 1920 ttcccactgc tgtcagaaca aatgtgtgat gagctggtgg cagagatgga gcactacggc 1980 cagtggtcag gcggccggca tgaggattca aggctggctg gaggctacga gaatgtgccc 2040 accgtggaca tccacatgaa gcaggtgggg tacgaggacc agtggctgca gctgctgcgg 2100 acgtatgtgg gccccatgac cgagagcctg tttcccggtt accacaccaa ggcgcgggcg 2160 gtgatgaact ttgtggttcg ctaccggcca gacgagcagc cgtctctgcg gccacaccac 2220 gactcatcca ccttcaccct caacgttgcc ctcaaccaca agggcctgga ctatgaggga 2280 ggtggctgcc gcttcctgcg ctacgactgt gtgatctcct ccccgaggaa gggctgggca 2340 ctcctgcacc ccggccgcct cacccactac cacgaggggc tgccaacgac ctggggcaca 2400 cgctacatca tggtgtcctt tgtcgacccc tgacactcaa ccactctgcc aaacctgccc 2460 tgccattgtg cctttttagg gggcctggcc cccgtcctgg gagttggggg atgggtctct 2520 ctgtctcccc acttcctgag ttcatgttcc gcgtgcctga actgaatatg tcaccttgct 2580 cccaagacac ggccctctca ggaagctccc ggagtccccg cctctctcct ccgcccacag 2640 gggttcgtgg gcacagggct tctggggact ccccgcgtga taaattatta atgttccgca 2700 gtctcactct gaataaagga cagtttgtaa atcttaaaaa aaaaa 2745 <210> 47 <211> 524 <212> DNA <213> Homo sapiens <220> <223> Genbank Accession No. AI937030 <220> <221> unsure <222> (1)..(524) <223> n = a or c or g or t <400> 47 ggaagggacc actgccttta ttgcctctgt gctggggtcc cagcctgggg ttcagaggcc 60 tctgggggca ataggtgacc ctggacccaa attattgcta cttggccagg tcaccttggg 120 gcttcccata ctgccctgag aatgggtggg atgagggcat gcaaacgata tgcaaatgac 180 atgcaaacca acccagaggc ctctggcaca tccatgggtg ctggaagagt caaagcctan 240 tggcctggga gggcgacggg gcacccagct caggcccagc ctcggaggca aggtttgagg 300 gttggggggt ccctgagcat cagccctgct tctgccgctg gctgaggagg agcagaagcc 360 tggtcccaag acagcaggaa gaaagcagga ccctcgctag gcggccagat ggcctgaggc 420 ccacccagac agggacggga cctgccctgn gtcgctcagc caggcaggga cagcagggac 480 cagaatccag gtctcctgag ccaggcagaa gccaaagtag cttg 524 <210> 48 <211> 571 <212> DNA <213> Homo sapiens <220> <223> Genbank Accession No. AI829890 <220> <221> unsure <222> (1)..(571) <223> n = a or c or g or t <400> 48 tttttttaac aggaaaaaat tatttaatag tataacaaaa tgcgaaataa agtacccaag 60 ttacaaaaca taaattcctt tggttcatga tcacaccact atttttacct tccacatagc 120 tacagacatc acaccctcaa agtgaagtca aactgtcccc ctcatactga agatgtcatg 180 ccaaaaccat cacatacccc actgttcagt gaaactgttg gcaacttaca tggaacagag 240 ctgtggggta ggaaaaaggg gaaagggttg cgttaaaaaa aatggggaga ctctacacat 300 gcanaacaag ttagtgggag ggagtgctct gctgggtcaa cacgccatga accacacccc 360 tattcgtgct acatgaggct gagtccttgc tacaaccaca cagaaataca gacaatcaag 420 tgaacctgag cacccccagg gataacagaa gaaaaataca gagaagcaga ggagagaaag 480 aatggcagca agaggcagat cacagaatac cagggaacac ctagtccaaa ccctgtttta 540 cagatgggga aagtgagacc tggagtagtg a 571 <210> 49 <211> 1204 <212> DNA <213> Homo sapiens <220> <223> Genbank Accession No. D17793 <400> 49 ctctgaggag aagcagcagc aaacatttgc tagtcagaca agtgacaggg aatggattcc 60 aaacagcagt gtgtaaagct aaatgatggc cacttcatgc ctgtattggg atttggcacc 120 tatgcacctc cagaggttcc gagaagtaaa gctttggagg tcacaaaatt agcaatagaa 180 gctgggttcc gccatataga ttctgctcat ttatacaata atgaggagca ggttggactg 240 gccatccgaa gcaagattgc agatggcagt gtgaagagag aagacatatt ctacacttca 300 aagctttggt ccacttttca tcgaccagag ttggtccgac cagccttgga aaactcactg 360 aaaaaagctc aattggacta tgttgacctc tatcttattc attctccaat gtctctaaag 420 ccaggtgagg aactttcacc aacagatgaa aatggaaaag taatatttga catagtggat 480 ctctgtacca cctgggaggc catggagaag tgtaaggatg caggattggc caagtccatt 540 ggggtgtcaa acttcaaccg caggcagctg gagatgatcc tcaacaagcc aggactcaag 600 tacaagcctg tctgcaacca ggtagaatgt catccgtatt tcaaccggag taaattgcta 660 gatttctgca agtcgaaaga tattgttctg gttgcctata gtgctctggg atctcaacga 720 gacaaacgat gggtggaccc gaactccccg gtgctcttgg aggacccagt cctttgtgcc 780 ttggcaaaaa agcacaagcg aaccccagcc ctgattgccc tgcgctacca gctgcagcgt 840 ggggttgtgg tcctggccaa gagctacaat gagcagcgca tcagacagaa cgtgcaggtt 900 tttgagttcc agttgactgc agaggacatg aaagccatag atggcctaga cagaaatctc 960 cactatttta acagtgatag ttttgctagc caccctaatt atccatattc agatgaatat 1020 taacatggag agctttgcct gatgtctacc agaagccctg tgtgtggatg gtgacgcaga 1080 ggacgtctct atgccggtga ctggacatat cacctctact taaatccgtc ctgtttagcg 1140 acttcagtca actacagctg agtccatagg ccagaaagac aataaatttt tatcattttg 1200 aaat 1204 <210> 50 <211> 2436 <212> DNA <213> Homo sapiens <220> <223> Genbank Accession No. X62078 <400> 50 aaggcacctc tgccgccaca gaccttgcag ttaactccgc cctgacccac ccttcccgat 60 gcagtccctg atgcaggctc ccctcctgat cgccctgggc ttgcttctcg cgacccctgc 120 gcaagcccac ctgaaaaagc catcccagct cagtagcttt tcctgggata actgtgatga 180 agggaaggac cctgcggtga tcagaagcct gactctggag cctgacccca tcgtcgttcc 240 tggaaatgtg accctcagtg tcgtgggcag caccagtgtc cccctgagtt ctcctctgaa 300 ggtggattta gttttggaga aggaggtggc tggcctctgg atcaagatcc catgcacaga 360 ctacattggc agctgtacct ttgaacactt ctgtgatgtg cttgacatgt taattcctac 420 tggggagccc tgcccagagc ccctgcgtac ctatgggctt ccttgccact gtcccttcaa 480 agaaggaacc tactcactgc ccaagagcga attcgttgtg cctgacctgg agctgcccag 540 ttggctcacc accgggaact accgcataga gagcgtcctg agcagcagtg ggaagcgtct 600 gggctgcatc aagatcgctg cctctctaaa gggcatataa catggcatct gccacagcag 660 aatggagcgg tgtgaggaag gtcccttttc ctctgttttg tgtttgccaa ggccaaactc 720 ccactctctg ccccccttta atcccctttc tacagtgagt ccactaccct cactgaaaat 780 cattttgtac cacttacatt ttaggctggg gcaagcagcc ctgacctaag ggagaatgag 840 ttggacagtt cttgatagcc cagggcatct gctgggctga ccacgttact catccccgtt 900 aacattctct ctaaagagcc tcgttcattt ccaaagcagt taaggaatgg gaaccagagt 960 gttttaggac ctgaagaatc tttatgactc tctctctttc actctttttt ttttttgtca 1020 ctaagttaaa agcgaagtga gagtattaac gtttttgttc tcctccggcc ccctgttaca 1080 atgaaggggc aaaagtattt gctcttagtc tattcctccc ttaacttctg tgactaattt 1140 ttatttcctt tctagatttg cccaattaat actagggtgc agtgtatcct ggagaggtag 1200 ggtgtgtggg ggaggaatcc cttgggggag atattaggag tgctctgttg tttacaaact 1260 cacggtaccc gcagggccta gcaagagact taaatgactg ataagaaccg tgagaaacat 1320 gttgcttcca ggcttgattt cgatttttcg cttttttttt ttttgagaca gaatctcact 1380 ttgtcaccag gctggagtgc agtggtgcaa tctcacctca ctgcaacctc cgcctcctgg 1440 gttcaagcaa ttctcctgcc tcagcctccc aagtagcttg gactacaggc cctgccacca 1500 cgcccggcta atttgtgtat ttttagtaga gatggggttt caccatgttg gccaggatgg 1560 tctcgatctc ttgacctcgt gatctgtcca ccttggcctt gcaaagcgct ggattacagg 1620 catgagccac tacacccagc cgatttttcc tttttgatta aagatgctat tacaatgtaa 1680 atatttctta cacagaaagt cacagcacat gtgcccattg atacaaggct gctgaggcct 1740 ggtctccagt tggaaatata attaagggtg gcaaggactg gagtcagttg gagagtgcat 1800 agccagtctg tgaagacaac tgccagatac tggcaatact ccagcctggt gacagagtga 1860 gactctgtct caaaaaaaaa gtttcaatgt ttactcctag agaagccaaa aatccagatt 1920 tgtatatgaa atcttaccat tttaaaagat tggcagctaa ttattttttt aaaaagctgt 1980 gcagtgtgat gtgtcccaaa cggactggct catgggtggc cacgtcacaa cctctgatct 2040 cagaccgtgc atgccttgtc ctcttaagac aactcctgtg gcaccgtttc tccctccaca 2100 gggccaaagc catagtgtcc ggtcccaagg acaaggctct tccagtgcta ggagaggtat 2160 gagcagcctc tcacctgtga gctgtgggga tcacaaggct gcctgcctca gtcttggagt 2220 cctgttgggt gaatgaggca gatgggaaag agcctcacca gcagctgctt ttggagcagg 2280 ggtccaagga agagagggtg gcctcgacat caaactgcct ggatttttct accaccctgt 2340 tacatcataa caacttctga aacacacacc agccctgagt tctgggctca tttgaagcct 2400 ggaatagcaa taaatctttt taacttgcgg acagtt 2436 <210> 51 <211> 3590 <212> DNA <213> Homo sapiens <220> <223> Genbank Accession No. L76191 <400> 51 cgcggacccg gccggcccag gcccgcgccc gccgcggccc tgagaggccc cggcaggtcc 60 cggcccggcg gcggcagcca tggccggggg gccgggcccg ggggagcccg cagcccccgg 120 cgcccagcac ttcttgtacg aggtgccgcc ctgggtcatg tgccgcttct acaaagtgat 180 ggacgccctg gagcccgccg actggtgcca gttcgccgcc ctgatcgtgc gcgaccagac 240 cgagctgcgg ctgtgcgagc gctccgggca gcgcacggcc agcgtcctgt ggccctggat 300 caaccgcaac gcccgtgtgg ccgacctcgt gcacatcctc acgcacctgc agctgctccg 360 tgcgcgggac atcatcacag cctggcaccc tcccgccccg cttccgtccc caggcaccac 420 tgccccgagg cccagcagca tccctgcacc cgccgaggcc gaggcctgga gcccccggaa 480 gttgccatcc tcagcctcca ccttcctctc cccagctttt ccaggctccc agacccattc 540 agggcctgag ctcggcctgg ttccaagccc tgcttccctg tggcctccac cgccatctcc 600 agccccttct tctaccaagc caggcccaga gagctcagtg tccctcctgc agggagcccg 660 cccctctccg ttttgctggc ccctctgtga gatttcccgg ggcacccaca acttctcgga 720 ggagctcaag atcggggagg gtggctttgg gtgcgtgtac cgggcggtga tgaggaacac 780 ggtgtatgct gtgaagaggc tgaaggagaa cgctgacctg gagtggactg cagtgaagca 840 gagcttcctg accgaggtgg agcagctgtc caggtttcgt cacccaaaca ttgtggactt 900 tgctggctac tgtgctcaga acggcttcta ctgcctggtg tacggcttcc tgcccaacgg 960 ctccctggag gaccgtctcc actgccagac ccaggcctgc ccacctctct cctggcctca 1020 gcgactggac atccttctgg gtacagcccg ggcaattcag tttctacatc aggacagccc 1080 cagcctcatc catggagaca tcaagagttc caacgtcctt ctggatgaga ggctgacacc 1140 caagctggga gactttggcc tggcccggtt cagccgcttt gccgggtcca gccccagcca 1200 gagcagcatg gtggcccgga cacagacagt gcggggcacc ctggcctacc tgcccgagga 1260 gtacatcaag acgggaaggc tggctgtgga cacggacacc ttcagctttg gggtggtagt 1320 gctagagacc ttggctggtc agagggctgt gaagacgcac ggtgccagga ccaagtatct 1380 gaaagacctg gtggaagagg aggctgagga ggctggagtg gctttgagaa gcacccagag 1440 cacactgcaa gcaggtctgg ctgcagatgc ctgggctgct cccatcgcca tgcagatcta 1500 caagaagcac ctggacccca ggcccgggcc ctgcccacct gagctgggcc tgggcctggg 1560 ccagctggcc tgctgctgcc tgcaccgccg ggccaaaagg aggcctccta tgacccaggt 1620 gtacgagagg ctagagaagc tgcaggcagt ggtggcgggg gtgcccgggc atttggaggc 1680 cgccagctgc atcccccctt ccccgcagga gaactcctac gtgtccagca ctggcagagc 1740 ccacagtggg gctgctccat ggcagcccct ggcagcgcca tcaggagcca gtgcccaggc 1800 agcagagcag ctgcagagag gccccaacca gcccgtggag agtgacgaga gcctaggcgg 1860 cctctctgct gccctgcgct cctggcactt gactccaagc tgccctctgg acccagcacc 1920 cctcagggag gccggctgtc ctcaggggga cacggcagga gaatcgagct gggggagtgg 1980 cccaggatcc cggcccacag ccgtggaagg actggccctt ggcagctctg catcatcgtc 2040 gtcagagcca ccgcagatta tcatcaaccc tgcccgacag aagatggtcc agaagctggc 2100 cctgtacgag gatggggccc tggacagcct gcagctgctg tcgtccagct ccctcccagg 2160 cttgggcctg gaacaggaca ggcaggggcc cgaagaaagt gatgaatttc agagctgatg 2220 tgttcacctg ggcagatccc ccaaatccgg aagtcaaagt tctcatggtc agaagttctc 2280 atggtgcacg agtcctcagc actctgccgg cagtgggggt gggggcccat gcccgcgggg 2340 gagagaagga ggtggccctg ctgttctagg ctctgtgggc ataggcaggc agagtggaac 2400 cctgcctcca tgccagcatc tgggggcaag gaaggctggc atcatccagt gaggaggctg 2460 gcgcatgttg ggaggctgct ggctgcacag acccgtgagg ggaggagagg ggctgctgtg 2520 caggggtgtg gagtagggag ctggctcccc tgagagccat gcagggcgtc tgcagcccag 2580 gcctctggca gcagctcttt gcccatctct ttggacagtg gccaccctgc acaatggggc 2640 cgacgaggcc tagggccctc ctacctgctt acaatttgga aaagtgtggc cgggtgcggt 2700 ggctcacgcc tgtaatccca gcactttggg aggccaaggc aggaggatcg ctggagccca 2760 gtaggtcaag accagccagg gcaacatgat gagaccctgt ctctgccaaa aaatttttta 2820 aactattagc ctggcgtggt agcgcacgcc tgtggtccca gctgctgggg aggctgaagt 2880 aggaggatca tttatgcttg ggaggtcgag gctgcagtga gtcatgattg tatgactgca 2940 ctccagcctg ggtgacagag caagaccctg tttcaaaaag aaaaaccctg ggaaaagtga 3000 agtatggctg taagtctcat ggttcagtcc tagcaagaag cgagaattct gagatcctcc 3060 agaaagtcga gcagcaccca cctccaacct cgggccagtg tcttcaggct ttactgggga 3120 cctgcgagct ggcctaatgt ggtggcctgc aagccaggcc atccctgggc gccacagacg 3180 agctccgagc caggtcaggc ttcggaggcc acaagctcag cctcaggccc aggcactgat 3240 tgtggcagag gggccactac ccaaggtcta gctaggccca agacctagtt acccagacag 3300 tgagaagccc ctggaaggca gaaaagttgg gagcatggca gacagggaag ggaaacattt 3360 tcagggaaaa gacatgtatc acatgtcttc agaagcaagt caggtttcat gtaaccgagt 3420 gtcctcttgc gtgtccaaaa gtagcccagg gctgtagcac aggcttcaca gtgattttgt 3480 gttcagccgt gagtcacact acatgccccc gtgaagctgg gcattggtga cgtccaggtt 3540 gtccttgagt aataaaaacg tatgttccct aaaaaaaaaa aaaggaattc 3590 <210> 52 <211> 3068 <212> DNA <213> Homo sapiens <220> <223> Genbank Accession No. U81802 <400> 52 gaagtcccta tcagattaca cttggttgac tactccggag cagccactaa gagggatgaa 60 caggcctgcg tggaaattga atgagattag ttgagtccac gctccatgag aatgctgaac 120 accatccaaa gcagcaaatt gagattcctt gatttgggga agaggtttgg gaggaaccct 180 tcaataattg gcatgggaca agaggggacc cagtccaagt gtatttggga ctcgcagtag 240 ggaggaacaa ttcagagaga gcttggaagc tcgaagtctg gctgtggcca tgggagatac 300 agtagtggag cctgccccct tgaagccaac ttctgagccc acttctggcc caccagggaa 360 taatgggggg tccctgctaa gtgtcatcac ggagggggtc ggggaactat cagtgattga 420 ccctgaggtg gcccagaagg cctgccagga ggtgttggag aaagtcaagc ttttgcatgg 480 aggcgtggca gtctctagca gaggcacccc actggagttg gtcaatgggg atggtgtgga 540 cagtgagatc cgttgcctag atgatccacc tgcccagatc agggaggagg aagatgagat 600 gggggccgct gtggcctcag gcacagccaa aggagcaaga agacggcggc agaacaactc 660 agctaaacag tcttggctgc tgaggctgtt tgagtcaaaa ctgtttgaca tctccatggc 720 catttcatac ctgtataact ccaaggagcc tggagtacaa gcctacattg gcaaccggct 780 cttctgcttt cgcaacgagg acgtggactt ctatctgccc cagttgctta acatgtacat 840 ccacatggat gaggacgtgg gtgatgccat taagccctac atagtccacc gttgccgcca 900 gagcattaac ttttccctcc agtgtgccct gttggttggg gcctattctt cagacatgca 960 catttccact caacgacact cccgtgggac caagctacgg aagctgatcc tctcagatga 1020 gctaaagcca gctcacagga agagggagct gccctccttg agcccggccc ctgatacagg 1080 gctgtctccc tccaaaagga ctcaccagcg ctctaagtca gatgccactg ccagcataag 1140 tctcagcagc aacctgaaac gaacagccag caaccctaaa gtggagaatg aggatgagcc 1200 tgttcgactg gctcctgaga gagaattcat caagtccctg atggcgatcg gcaagcgggt 1260 ggtcacgctc cccaccaaag agcagaaaac acagaggctg atctcagagc tctccctgct 1320 caaccataag ctccctgccc gagtctggct gtccactgct gggtttgacc accacgtggt 1380 ccgtgtaccc cacacacagg ctgttgtcct caactccaag gacaaggctc cctacctgat 1440 ttatgtggaa gtccttgaat gtgaaaactt tgacaccacc agtgtccctg cccggatccc 1500 cgagaaccga attcggagta cgaggtccgt agaaaacttg cccgaatgtg gtattaccca 1560 tgagcagcga gctggcagct tcagcactgt gcccaactat gacaacgatg atgaggcctg 1620 gtcggtggat gacataggcg agctgcaagt ggagctcccc gaagtgcata ccaacagctg 1680 tgacaacatc tcccagttct ctgtggacag catcaccagc caggagagca aggagcctgt 1740 gttcattgca gcaggggaca tccgccggcg cctttcggaa cagctggctc ataccccgac 1800 agccttcaaa cgagacccag aagatccttc tgcagttgct ctcaaagagc cctggcagga 1860 gaaagtacgg cggatcagag agggctcccc ctacggccat ctccccaatt ggcggctcct 1920 gtcagtcatt gtcaagtgtg gggatgacct tcggcaagag cttctggcct ttcaggtgtt 1980 gaagcaactg cagtccattt gggaacagga gcgagtgccc ctttggatca agccatacaa 2040 gattcttgtg atttcggctg atagtggcat gattgaacca gtggtcaatg ctgtgtccat 2100 ccatcaggtg aagaaacagt cacagctctc cttgctcgat tacttcctac aggagcacgg 2160 cagttacacc actgaggcat tcctcagtgc acagcgcaat tttgtgcaaa gttgtgctgg 2220 gtactgcttg gtctgctacc tgctgcaagt caaggacaga cacaatggga atatcctttt 2280 ggacgcagaa ggccacatca tccacatcga cttcggcttc atcctctcca gctcaccccg 2340 aaatctgggc tttgagacgt cagcctttaa gctgaccaca gagtttgtgg atgtgatggg 2400 cggcctggat ggcgacatgt tcaactacta taagatgctg atgctgcaag ggctgattgc 2460 cgctcggaaa cacatggaca aggtggtgca gatcgtggag atcatgcagc aaggttctca 2520 gcttccttgc ttccatggct ccagcaccat tcgaaacctc aaagagaggt tccacatgag 2580 catgactgag gagcagctgc agctgctggt ggagcagatg gtggatggca gtatgcggtc 2640 tatcaccacc aaactctatg acggcttcca gtacctcacc aacggcatca tgtgacacgc 2700 tcctcagccc aggagtggtg gggggtccag ggcaccctcc ctagagggcc cttgtttgag 2760 aaaccccaaa ccaggaaacc ccacctaccc aaccatccac ccaagggaaa tggaaggcaa 2820 gaaacacgaa ggatcatgtg gtaactgcga gagcttgctg aggggtggga gagccagctg 2880 tggggtccag acttgttggg gcttccctgc ccctcctggt ctgtgtcagt attaccacca 2940 gactgactcc aggactcact gccctccaga aaacagaggt gacaaatgtg agggacactg 3000 gggcctttct tctccttgta ggggtctctc agaggttctt tccacaggcc atcctcttat 3060 tccgttct 3068 <210> 53 <211> 662 <212> DNA <213> Homo sapiens <220> <223> Genbank Accession No. AW004018 <400> 53 tttttttttc caaacaatta atttataaaa ataacaaaac atttgtctat gaaaaaaaga 60 tcaggattca ctctcatcga cgtcctcatc tggatggggc tcagcatcct ccttttcctg 120 ctgctgtttc ttccacagtt tggccatggc caggagtttg aggttaggtt ggttggcagc 180 atcttctgga aagatgtaat caaagtattc ttcccagcct gcatcagacc catcatcagt 240 ctggaccttt cttctcttct tgactttctc tggcatgagt ttgtctactc tctccttatc 300 tgaagctgtt ccaaattctt cttcaaaact tcgccaagat tccagcagca taagtctctc 360 ttccttttct tcacagtttc gcatggtttt gttagcttct tcataaattt gtctgcattt 420 agtcaaactt ccttcttttc ctgaagacaa ctcaaactga gcaaagctga tccatacctt 480 acatgctgcg tccgttgaag caaccgccgg taaaggtttc gtgttctttc tgtttcttcc 540 tgctcaattt caaaatcaat atatgatttc caaagcacct ctggcatgtc taaacgtggc 600 tgactgatgg ctaattcata gattgcccgg gctctgtcaa tatcaccaag gattgtctct 660 aa 662 <210> 54 <211> 75270 <212> DNA <213> Homo sapiens <220> <223> Genbank Accession No. AF023268 <400> 54 tcccagggtc ccgggttggg ggggtggagc agcatttcgt cgccgcgggg gtgccgggac 60 tccggccgca gtgtcgccgc catcacggac ttcctgtggg acaagcgcac gggcctcgcc 120 gccagaacgg tgagcgcgcg ggttggctgg ccgcgcgaaa agatggcgac cgcggggcgg 180 gcggggttag gcttgggttg ggggcaaggg acgggggcga gatttggaga ggaggagagt 240 tgagacctac gaagcgacgg agtagggaga tgagggggaa ggaggtcggc ctgcgttaga 300 tgtaccaaga agacctgtag gaagcttggg cggaaccaga ctagaaggga tgatagagta 360 aggatgggag tggttccaga gatgtgaagg agtggaatat caaagttgga ctcgggtcca 420 atcaaagctg gaggggagga atacatcacc gtgtcacttg gaacatgcag gaagaatttg 480 cctgtaggag ttctggattt tctgagtaag aaaggaaaaa gcaaaagatt tcaaacttga 540 gaaaggtagg ctagtgatgt tttgagggga cagtgctgtg aggccgtttg atggtagtat 600 gtggtgagat ggcatttatg tggctatgct gattaggata actatgctgg gaaaatcttg 660 tgcttgcagc ttggtatgct accggcccca gttacaccaa gaatgcatca aataccaccc 720 tcctcaattt ggggaggttg ggaagaagtg tatacagaat ggtggtcaga catcggaatc 780 attaaacctt ttgcatacgc gattctcata cacccccacc aagacttatg tccctgggcc 840 tgtttcattt tattgtgcct tcctattctc atcttcctgg attgtgacag tgatttttct 900 cttttttcct tgaaggaaaa aaaggatttg tgaaccatcc cattccaatt ccattaactg 960 gaaggtggcc agctgtcagc taagtagggc tgatattaat taaaaaccac ttactggcca 1020 ggcgcggtgg ctcacatctg taatcccagc actttgggag gccaaggcgg gcggatcacc 1080 tgaggttggg agttcgagac cagcctgacc aacatggaga aaccctgtct ctactaaaaa 1140 tacaaaatta gctgggcgtg gcggcgcatg cctgtaatcc cagctactcg ggaggctgag 1200 gcaggagaat cgcttgaacc ctgcaggcgg aggttatggt gagccgagat tgcgccattg 1260 cactccagcc tgggcaacaa gagcaaaact ccgttttcaa aaaaaaaaaa aaaaacacaa 1320 gaaacagttg ttatctacgt cttaagcaca agagtggagg ggccagatgg gatgctgact 1380 gtattttgtg gcctactaca ttaaaacctc tcaagggaga gttggccaaa gatgtgagag 1440 atgattaagt taattcaagg ggcccgaccc agatccctgg agctgatagt atttggcgtt 1500 tacctggtat atgtagaaac ctgggagact ggattcctac cctcaggaca ctgatagtct 1560 acttgaggag atgagatgta ctcttaatga gtgtacaaca tttatcataa ctgtaaacca 1620 aagctttact ctattgactt gtgaggaact cagcatcaca cagatctata tcttagatcc 1680 tgaacgggga tacactgtgg cagtctccat cggtcgtcat acactttgct ctgtagtgaa 1740 ctgtgtccta gacctgaagg tcttcatgga gctgtgtttg aagaaaataa ggatagaaca 1800 cttgaactgg ctgggtgcgg tggctcacgc ctgtaatccc agcactttgg gaggccgagg 1860 caggaggatc acgagtcagg agtttgagac catcctggcc aacatggtga aaccccgtct 1920 ctactaaaaa tataaaaatt agccaggagt ggtggtgcgt gcctgtaatc ccagctacac 1980 aggaggctga ggcaggagag ttgcttgaac ctgggaagtg gaggttgcag tgagccgaga 2040 ttgtgccact gcactccagc ctggccacac agcgagactc tgtctcaaga ataaaataag 2100 aacacttgaa ctgaggggtg ggtaatgagg gatgggtttg ggggctttct agagtttcag 2160 ccagagttag taggtggctg tactccaata aggaggaatt gtaagtacag aggaagactg 2220 aggaagttgt gcctggtaaa aagaggcaga aataagaggg gaaagcagct tagcatcttt 2280 ggagcagcca gtccttggag gagatttctg aaaactcgaa actttcctat ttccgctttc 2340 ccttgccttc cagatgccgc atcctcgaag gtaccactcc tcagagcgag gcagccgggg 2400 gagttaccgt gaacactatc ggagccgaaa gcataagcga cgaagaagtc gctcctggtc 2460 aagtagtagt gaccggacac gacggcgtcg gcgagaggac agctaccatg tccgttctcg 2520 aaggtgaggc ctcaggaaga gatactcaaa cacagggtca ctcgctcatt cctttgttca 2580 acaaatactt attggttata tgctaaaacc attgccttaa gtagctggct gaaggtaatg 2640 tcgggataga taaccacaga agccatttgg gctgcagtgt taagtgttag aatacataat 2700 gaggaactga ggacgtaccc agtgcgtttg gttggagtgg ggcaggatgt taattcagat 2760 aaaacattgc agaaagcaac atctgtatat gtctggagga caagtagagt caggtggggg 2820 aagtgtcttt gggcagaggg aaagcatgtg caaaggactg ggagctacag gtaactaata 2880 agctaacaga taagacaaag ttagatcttt gtgtttttaa ttttttaaaa attttaaaat 2940 atcatttatt tatttttgag acagagtttc actctgttgc ccaggctgga gtgcagtggc 3000 aagatctcag ctcactgcaa actctatggc cccaggttca agttgattct tgtgcctcag 3060 cctcccaagt tacctgggac tacaggcatg cgccatcatg cctggctaat tttttttttt 3120 tttttttgta tttttagtag agacaggatt tcaccatgtt ggcctcaaac tcctgacctc 3180 aagtgctcca cctgccttgg cctcccaaag tgctgggatt acaggcgtga gccactgtgc 3240 ccggcccagt tttaatattt tagtggtatg ttcagtggaa agaatgggtt aaggatggtt 3300 tagagcaagg ggggatttca ttcaggaaag cttgagaaaa aaatggctct ttgtttcttt 3360 gtatcactgc agcgggaaaa aggccccaat agggagtggt tctgcagatg ccttttcaga 3420 ggttttggtg acatggcaga tgtgcttggt taacctcaac ttcttctggt cccttggtcc 3480 tctccagtga ctcaaacaag tgtctgagaa cagtttttct tagcattcac tctttgtcct 3540 cactaaggca ggaccttgtc acagggtatg gtagggaatg tgatctgaac agatacacct 3600 cattggtatt tgttatccaa cagcagttat gatgatcgtt cgtccgaccg gagggtgtat 3660 gaccggcgat actgtggcag ctacagacgc aacgattata gccgggatcg gggagatgcc 3720 tactatgaca cagactatcg gcattcctat gaatatcagc gggagaacag cagttaccgc 3780 agccagcgca gcagccggag gaagcacaga cggcggagga ggcgcagccg gacatttagc 3840 cgctcatctt cggtgagtgc cagcccaggc ccttcctctc cccactcttc tgcaggccct 3900 ctaggactct ggtaagtgag cagtatcctt gttctcagct gaacattggg gcatgaacac 3960 tgaggtgggc actgagtttg cctactttct tggaagctct ccgactcttg aagggccctg 4020 gatctgcttt ggagatggat gggcacggag catttgtgac ccccagtgct ctccctggca 4080 tgttgggctt attgtgttgg gagcagcttc tccgccccag cggcctccac tctttaatgg 4140 ggaccttgct tgttgaactg cctttttccc ccaagccctg ggctctgtag cccccttggc 4200 aggcgggctt gggtgggggc aaggggagat ctgtgtctgc ccggaagggc attgtgtaga 4260 gcatggggtt gtgggtgaca ttggcaacaa caccacttct ctgctctgcc catgcctctc 4320 cctgttcctg ttttgggttt ggggacttgg gattatgcgc cgctctctct tctcacaccg 4380 atccacctta ctgcatctga cgtgttccct tccactgtcc cccatcatcg tctgtccccc 4440 ctggctgggc gcctgtgacc ggtgacccct ctaccaccca ccccgcctcc ctccggcccc 4500 cggctccgaa cactgggctt ggttcggaac cccccctgcc ccccgacagc agcacagcag 4560 ccggagagcc aagagtgtag aggacgacgc tgagggccac ctcatctacc acgtcgggga 4620 ctggctacaa gagcgatgta caagccaaat cgtaacaatc ctatagcctg taatggtccc 4680 atagccatcc taacgtccca agccaacctg agtcacagcc tcttgccttt tgctcagtgg 4740 tgttgtttat ctgggtggtt tgagttgctg ttgagaattg acctctgttg tccactccca 4800 gctctcacgg cccctgggtt aaaggtggtg ggaatcacgc aggggttttc ttcccctgtg 4860 accatctgta tctgttcccc ttccttcatc tccaccccag gttgctgtcc ccttttttct 4920 tccaactcag ctcattcccc accttctctc cctccctctc cccgaccctg ctctctttca 4980 tttcagatga aatcgttagc accttaggag aggggacctt cggccgagtt gtacaatgtg 5040 ttgaccatcg caggtaactg tcagtccctc cctactatgt ggggctaaag agatggttgg 5100 ggttatatgg ggcttttttg ctaattaacc tgaggtagaa tttcttagtc cccctacagc 5160 cctgttcatt ttgagacatt cttgagaacc cagcaaaagc ctctcctgcc aacttacagg 5220 ggtggggctc gagttgccct gaagatcatt aagaatgtgg agaagtacaa ggaagcagct 5280 cgacttgaga tcaacgtgct agagaaaatc aatgagaaag accctgacaa caagaagtaa 5340 gcaagcaagg aagtgtgtag ggaggctgag agccccaacc cctacacggg agagattcct 5400 agacctggtt taggcagaca gggggagtcc tagaccttct catccattca tcttttgttc 5460 atcatcttag agtagtagaa catcagggta ggaaaggggg ggggcccatg acattcctta 5520 atccactccc cttgttttca gggaagttag attgctctgt cgtttgaccc cagcctagaa 5580 tggcttctgt agagatatac cctggacata gccctaggac tgagcatcaa cctcatcgaa 5640 caatgaatta agcttttata agtagaacta tgctgataag gccacagaca tttatgcagt 5700 aatattttgt tcacatacat tcacagtcca aaaatagaat aaggacttta agccaagata 5760 tgaggccagt aggtataaat aggagcccag tggtagctag tggtgaatga atatcaggag 5820 ttgggctggg gtttgggatt taggatggac agtttgatga ttccaggatc tatactgttt 5880 ggagcttggc actccacagc tcttccagca aatagttttt gaactattta aaatgacgca 5940 ggaagatatt ttgaaacttg ggctgggcat ggtggctcac gcctgtaatc ccagcacttt 6000 ggaggccgag gcgggtggat cacaatgtca ggagttcgag accagcctgg ccaatatggt 6060 gaaaccccgt ctgtactaaa aataaaaaaa ttagccgggc atggtggtgg acaactgtag 6120 tcccagctac ttggaaggct gaggcaggag aatcgcttga acaggaggca gaggttgcag 6180 tgagccaaga tcgcgccact gcactccagc ctgggtgaca gagtgagacg ccatctcaaa 6240 aacaaaaaag aaaaaaacat ggcagatagt accatttctt tcttgggtct ggtagaggct 6300 actccttagc tgaactgaat tttggtgtta gtactagctg gcatggtttt acacaagtta 6360 tgtggaatca acagctatga agtacctcct tgttggatgg ctgatgggca gatgggagct 6420 catcagacaa tcccccttcc cccatctctc ttctcagcct ctgtgtccag atgtttgact 6480 ggtttgacta ccatggccac atgtgtatct cctttgagct tctgggcctt agcaccttcg 6540 atttcctcaa agacaacaac tacctgccct accccatcca ccaagtgcgc cacatggcct 6600 tccagctgtg ccaggctgtc aagtgtgagt ggggtgggcc gaagtggact ctggggcagt 6660 ccctcccttc attggatctc ttctgtcggt tgtgcactgg tgaagcccct aaacagtcag 6720 ctgtctgtta tctgcagttc tttgatttac tgtcatcttg aaacgtcttc tgacttaact 6780 ccttgactga tgtctttatc gtcactgatt gctcttactc tacacctagc ctagcagcag 6840 ctagaagaga aagcctttgg aatcaaagca cttaattacc ctcccctttt cctttctccc 6900 tttcttggga aagcatcagt cagacagcaa acataaagag acaaaaatac actccttagg 6960 gtaaaggctt acatttgtct gggatgagat gttcattcac agcaaaggag atgggaacac 7020 agagtatgta gttcagctaa ggggcaaggt ggggaattca aagaaatata tcattcctct 7080 ggagtcatca aaataataca gtttcacaga attgagttaa cataatgcca gctagacaca 7140 tgtcaaagtg tgtacacact acaactcaaa gcaaactttt ttttttttta catcagttga 7200 gctacatatg tatcttacat tagaaagagc agagcttctt agaccaggca ttccatttag 7260 acgtagagcg gaaagcagcc ctagtgattc tggacctgtc tcctcactgg ctttgcccta 7320 ggtaaccagg cctggggtca gctgatacca gttagctctg gccacctgca ccaagcctga 7380 cctggccttc tcccctacag tcctccatga taacaagctg acacatacag acctcaagcc 7440 tgaaaatatt ctgtttgtga attcagacta tgagctcacc tacaacctag agaaggtaag 7500 atggataggg tctgcccttg gttactgggg gcaggcagct gcaccacttt gccttctgcc 7560 gagccctttg ttttctccct tttatttcgt cctcccacat tttctccctg actggctcca 7620 actgggtaaa actaaatagg ttgaaaggga gaaatctctt aagaagactt aaattgggag 7680 ataacttgta caggggactt cagataactt tccagtagag tgaaagtttt taaggttctt 7740 ggtttgggct ttatttattt atttatttat ttatttattt atttatttga gacagagtct 7800 cactctgttg cccagactga tgtgcagtgg cataatctcg gctcactgca acctctacct 7860 cccaggttta agtgattctc ctgcctcagc ctctggagta gctggggtta caggcacccg 7920 ccaccacgcc tggctagttt ttgtgttttt agtagagatg gggttttgcc atgttggcca 7980 ggctggtctc gaacccctaa cctcaggtga tctgcctgtc tcgggctccc agaatgctgg 8040 gattacgggt gtgagccaca gtgcctggcc cggacttctt ttttgagatg tgtatttctg 8100 tgaggtagga aagctcggct cctttgacta actggagata atgaagatct cagacctaaa 8160 gaagctctcc ctcctttgac ccctttgcta catgttacat atttttagag aaactccttt 8220 gctacatgtt acattttttc agaaaaaccc atttgctaca tgttacattt tttcagaaaa 8280 acccatttgc tacatgttac atgttttcag aataactata tatctggcac ttgagtgtag 8340 tcttcagatg cttacagatg tgcacgctgt tctataatca tttcttaatc cttttgctcc 8400 cctacttcta aaagtattat gctggatgtg gtggaagctg taaaacagga atttcccagg 8460 cttgtaaggc caggcaggag atcacagtac cttttttaag gctcagaagc aatgtagaga 8520 atactggtgg aatctcagtc tgggtgcaga ggttcatcct ctttctcctc tgctcctaga 8580 agcgagatga gcgcagtgtg aagagcacag ctgtgcgggt ggtagacttt ggcagtgcca 8640 cctttgacca tgagcaccat agcaccattg tctccactcg ccattaccga gcaccagaag 8700 tcatccttgg taagggaggg caaggctgtc caagtgtgtg agatgatgtg agggtggggc 8760 cacctaagcc tcataacacc ttttccctcc cattctcacc cagagttggg ctggtcacag 8820 ccttgtgatg tgtggagtat aggctgcatc atctttgaat actatgtggg attcaccctc 8880 ttccaggtaa gtgatgggat gtcttacttg actgcctggc attcttctac ctggttcctt 8940 tgttttctgc tgaggacctg cctactcagt tctccacatt gcctgccttc ctggcagctg 9000 atccttagca tgcccttttc agtcccatgc tcagtttctg tttttgtttc ccagacccat 9060 gacaacagag agcatctagc catgatggaa aggatcttgg gtcctatccc ttcccggatg 9120 atccgaaaga caaggtgaac cttgaggggg cactagttaa ctcttttcct tttctctcca 9180 cagaattggt ctatttcaca tcattttctt ttttctttga tacctcctct ccccccagtt 9240 actttcagat ggggaaataa gggaattgta acaagggtga ccttctgatt cctcaacctc 9300 cccttcccct ctagaaagca gaaatatttt taccggggtc gcctggattg ggatgagaac 9360 acatcagctg ggcgctatgt tcgtgagaac tgcaaaccgc tgcgggtgag ctgggctcgg 9420 gataaatagt gcccaccgtc cagaagtcac ttccttctta gggtggttgc cccctggaat 9480 gctcttcaac aagccagagg gttaggaaag gaggggagga aagctgaaag aagacatctt 9540 tggtcaacag aggaaacata agagggagtg gttttgcgga gggaaggagg ttagacagcc 9600 taaccttgag acaaccagag atcaaagcaa tgtcctggat tctttaggtc agacagaaaa 9660 gaataaacta cccttgaaga gcttacattt taatgaggaa ctaaagaaga ttcatgaagt 9720 tgacaaggat atacaagtag aaagaacttt caaagattat ggagtaattg tgctagaggg 9780 aaggtaggtt gagctataat atcagaaacg ttggtcctgg tgtggtcgtg gttaggtagc 9840 cttcaaattg gttgcaagca gagccttggt tctccaagaa tgaaaggtag ggtcttgaag 9900 aaggcagggt ttgtaaggca tcctgcctca cctttttcct gccctcctcc accagcggta 9960 tctgacctca gaggcagagg aacaccacca gctcttcgat ctgattgaaa gcatgctaga 10020 gtatgaacca gctaagcggc tgaccttggg tgaagccctt cagcatcctt tcttcgcccg 10080 ccttcgggct gagccgccca acaagttgtg ggactccagt cgggatatca gtcggtgacg 10140 atcaggccct gggcccccct gcatctttta tagcagtggg tgtccagtcc aggacactgg 10200 tgctttttta tacaagagaa cgagccagag ttcactcctt cctcctggct ctctatatac 10260 ctgtgaatat gtgaaatagt gtaaatatga aagaacttgt acctatcact tcaacccctg 10320 ccttgtacat aatactattc catccacaca gtttccaccc tcacctgccc cctcatacgg 10380 agttggatgg gggccgagtg aggtaaccag gtggcatcta ccccatgttt tataaggaat 10440 tttgtacagt ctttgtgaaa taaaataacg tgcttcattt gacccccatc cctggagttg 10500 gaggtttggg aatgctgggg tggagggatg aaactattgg caaactttct gagtttgggt 10560 atgaagggag tcctccttac cctccaaaat gaagcacagc caggctacca tttatttccc 10620 ctgtccacct tatcatatgg gagggtagtg atgggtgggg cagcatttct ttcagattaa 10680 aacagagaag tgttatgagg tggcacttct cggatgtgga attatgagag ttgggaagat 10740 ctgactccta gagtcattag gccgcggccc agtatagagc cagaaactca ggttgaaaac 10800 gtgctcaacc tggctcctag gggggattgc caggaccggt cagaaggctc ccgtcgtcca 10860 tctcgggaga ctaggaaggc cggattccta cgcgaggcct gctgggaagt gtagttcgtt 10920 agtggaagga agtcacatgg aagaggggcg gtagttggtt gtgggcactg ggttagaggt 10980 atcacgtggg ggcactttcg tcttagcttt tggacaagac gcaggcgcaa acccacggct 11040 gctgcggggg atccttgtgg ccctttccgg tcggtggaac caatccgtgc aacagagaag 11100 cggggcgaac tgaggcgagt gaagtggact ctgagggcta ccgctaccgc cactgctgcg 11160 gcaggggcgt ggagggcaga gggccgcgga ggccgcagtt gcaaacatgg ctcagagcag 11220 agacggcgga aacccgttcg ccgagcccag cgagcttgac aacccctttc aggtgacttg 11280 cgccagtcgg cctcttttgg gcggtcaggt tgattcttcc cggttctgta gggtcgggct 11340 aacttgtatc cccatttgtg acatttgatc ctgggaagag ccgccacgtg gggtgacagt 11400 gactccagac cagtgagcac tctggggggc gggccctgcc ccttaatggg ctggtgctgg 11460 cagtgttgga tgatggattt gaggtaaatg ttgtcccagt cctgggacaa cggcgtggcc 11520 ccgaaggtgc agtacttgga gccacaggca gtttgggaat ggtccctggg aattccccta 11580 ggtggcactg ggtgccagct gagacccggg tctctgccct caggacccag ctgtgatcca 11640 gcaccgaccc agccggcagt atgccacgcg tgacgtctac aacccttttg agacccggga 11700 ggtgagctac tggagagcat aggagttcaa ggaagggaag ggtttgccag tgagacaagt 11760 tagcttgggt acaggggact tttctgcatg cacaggaagg aagaggcact gtgatcttag 11820 ttccctgaga gaggctagtc agccatggga tgcctcatcc ttctagggcc accagggcca 11880 ccaacccaaa tggtttgagc tctaaaagtc agtcctggga agatctggag gctggcaagg 11940 ccttaaccaa tgttctgtat gggaaggctt tcttgaagaa aataaaggtt ggggctggtt 12000 ggagtttagg ttaggtgtgc agtttgaaag caaggaatga ggaggactac acctgtttgt 12060 cccactggat tagaagatgg tgagttgtaa gaatttaagg ggttttcatg gtacttaaaa 12120 cttaaaaaaa aaagccaagc atggtgtgca tgcctgtaat cccacttggg aggctgaggt 12180 gggaggattg cttgagccca ggaatttgat ggagaccatc ctgggcaaca gcgagacccc 12240 catctcttga gacgttttaa aaattggcta ggtgtagtgg cacatgcctg tagtccttgc 12300 tacttgggag gctgggatgg aaagactgct tgggcccagg agtttgaggc ttcgatgagt 12360 gatgattgca ccactgcact ccagcctggg tggcagagag acaaccccac actccatccc 12420 cagaagaaaa gagaaaaaaa aaacacagtt aagtggggag atatggtaaa tgagtgattt 12480 gagtcctcac taaggaattg gatatgaggg atgataaggc tgctacaggt catcatagag 12540 ttctctgaca gaaattcaac agaagaacta gcttcctaac aaatggggga aaggctgctt 12600 ccttacatca tgagttctgg gtctaaaggt attcaagcag actatagatt cctgtgttat 12660 gagggactag atgatcacta aggtcttttc ctcaacagcc accaccagcc tatgagcctc 12720 cagcccctgc cccattgcct ccaccctcag ctccctcctt gcagccctcg agaaagctca 12780 gccccacaga acctaagaac tatggctcat acagcactca ggtacaggag gtgtgcaggt 12840 gagggctggg gagaagggcc agtcctgggg cccagggctc acatctccgt ctgctcacac 12900 tgggcaggcc tcagctgcag cagccacagc tgagctgctg aagaaacagg aggagctcaa 12960 ccggaaggca gaggagttgg accgaaggga gcgagagctg cagcatgctg ccctgggggg 13020 cacagctagt aagtaataga gtggggaaga gcatctgaga gtttgggagg agcaaaaaca 13080 ggtcttaagg gcctgggctc ggctgggtgc ggtggctcac acctataatc ccagcacttt 13140 gggaggctga ggtgggcgga tcacgaggtc acgaggtcaa gaaatcgaga ccatcctagc 13200 caacatggtg aaaccctgtg tctactaaaa atacacacac acaaaaatta gctgggcatg 13260 gtggcgcgca cctgtagtcc cagctactcg ggaggctgag gcagggagaa tcgcttgaac 13320 ccgggaggtg gaggttgcag tgatccgaaa tacgcgccac tgcactccag cctggtgaca 13380 gaaatgagac tccatctcaa aaaaaaaaaa acacaaacct gggctctgga gtcagactgc 13440 tgagtttgaa ttttagagat actgcttact aaccatgagc ttttagggaa gttacttaat 13500 cttgaatgcc tcagtttccc tatttataaa atgaaaacca cgtttgcatc cgtttgacag 13560 ggttgttgtg aaggttaaac aaaatatatg tgaagtactt ggtacagtgc ttagatgttt 13620 taaataataa taaacagtat taatttttcc actctcactt gtctccttgg accccaaatt 13680 ggagataaaa gagaggatcc agggctgggt atggtgcctc acgcctgtaa ttccaacact 13740 ttgggaggcc gaggcaggca ggttgcttga gttcaggagt tagagaccaa cctggacaac 13800 atagtgagat cctgcctcca aaacattaat gaaaaaaatt agcagggcat gatgtacctg 13860 tctgtagtcc tagctcctca agaagctgag gtggacggcc aggcgccggg gctcatgcct 13920 gtaatcccag cactctggga ggccaaggcg ggtggatcac ctgaggtcag gagttcagga 13980 ccagccaaca tggtgaaacc ctgtctctac taaaaataca aaaattagct gggcgtggtg 14040 gcatgtgccc ataatcccag ctactcagga gactgaggca ggagaattac ttgaacccgg 14100 gaggcggaga ttgcactgag ccaagatcac accactgcac tccaacctgg gcaacaagag 14160 cgaaactcta tctcaggaga aaaaaaaaaa aaaaaaaaag ctgaggtggg agggttgctt 14220 gagcccagga ggttgaggct acagtgaacc atgatcatac cactaccttc cagcctgaac 14280 aacagagacc ctatctcaaa aaaaaaaaaa aaaaaaaaag agaggatcca gggatggaga 14340 gaagggggag tgattccttt gttggtctct gttttacttc tggggtccac ctgttttttg 14400 gcgccttaca gctcgacaga acaattggcc ccctctacct tctttttgtc cagttcagcc 14460 ctgctttttc caggacatct ccatggagat cccccaagaa tttcagaaga ctgtatccac 14520 catgtactac ctctggatgt gtgagtagtg agaagccttt tggaggaagt tacaggtaga 14580 tctcttaact gccctggggt ccgctcacca agaaccaaac acttcacctc tatttagaac 14640 tcaccagcct gctagcaaat gttcttgccc tctccccact ttttattgtc catatgcagg 14700 aatatatttt gaattcttta gatgtctttg ggctgggtgc agtggtatac gcctgtaatc 14760 ccagcacttt gggaagctga ggtgggtgga taacctgagg tcagaagttt gagactagcc 14820 tgatcaacat ggagaaaccc catctctact aaaaatacaa aattacctgg gcgtggtggc 14880 acatgcctgt aatcctagct actcaggagg ctgaagcagg agaatcactt gaacccggga 14940 agtggaggtt gcaatgagcc aagatcatgc cattgcactc cagcctgggc aacaagagca 15000 aaactccatc tcaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaggc cgggcacggt 15060 ggctcacacc tgtaatccca gcactttggg aggcccaggt gggcagaaca tgaggttagg 15120 agatcaacac catcctggct aacacggtga aaccccgtct ctactacaaa tacaaaaaat 15180 tagccgggcg tggtggcggg tgcctgtagt cccagctact taggaggctg aggtaggaga 15240 atgggcgtga acccaggagg cagagcttgc agtgagccga gatcctgcca ctgcactcca 15300 gcctgggcga cagagcgaga ttccatctca aaaaaaaaaa aagaaaaaaa aaaattagct 15360 gggcgtggtg gcgggcgcct gtagtcccag ctactctgga ggctgaggca ggagaatggc 15420 gtgaaccggg gaggcggagc ttgcagtaag ctgagattgc gccactgcac tccagcctgc 15480 gcgacagagc cagactccgt ctcaaaaaaa aaaatgtctt tgcaagggga tcacacatta 15540 ttgacatttg ctttctccat ctcccctgtt gaggattcca tgaaggcagc agctgccttc 15600 atttccttac tctgccatgt ttggtgaata ttataggatg agcatagatg ggaaggagcc 15660 ttcattgcag tccagaaggg ctcctcatcc tgtccctctg ccccttaggc agcacgctgg 15720 ctcttctcct gaacttcctc gcctgcctgg ccagcttctg tgtggaaacc aacaatggcg 15780 caggctttgg gctttctatc ctctgggtcc tccttttcac tccctgctcc tttgtctgct 15840 ggtaccgccc catgtataag gctttccggt aagtgtgtta gtggtgggag agtgatggag 15900 acctgggatg ggccccacgt ctgcccatcc ttcagctcta attcttctcc caccctcccc 15960 atttttttcc tctttgtagg agtgacagtt cattcaattt cttcgctttc ttcttcaatt 16020 tcttcgacca ggatgtgctc tttgtcctcc aggccattgg tatcccaggt tggggattca 16080 ggtttgtgag gctgttatcc accctcacct ttccctctag atccagccag cactgggtgc 16140 tggataggag ttgttcagaa aaaggaaatg tggttttaat ccttgggagg tactagttta 16200 atgagataca agacatactt ccaggataga gcgcagacag cactcttgac acatatagat 16260 tgaagggaag aatgctgcat ttggccaatc taaggtggct tcctggagga ggcatagaac 16320 catggttgaa aggaggaaga agaatcccca gatgagtgcc tggaagagct tggagagctc 16380 agggctaatg gttcagaaac tggaattaaa ctatgaagag attagataca gtttgggatt 16440 gtggtgcttg gaatgctgct cgattgacag ggagccactg ctgatgggaa gggtaggaac 16500 aggggatgct ggtgacataa ccagtggaga agctgaggag cccctcttca ctggtacatc 16560 cttcccttta cagtggctgg atctctgctc tggtggtgcc gaagggcaac acagcagtat 16620 ccgtgctcat gctgctggtc gccctgctct tcactggcat tgctgtgcta ggaattgtca 16680 tgctgaaacg ggtgagggct gtgtcgaagg tggggccggg atggtgagat catgggtccc 16740 caggggcgtg ggtggaacat tcaggagcaa ctggcacagg tcaggctgct gggttgttct 16800 cagctaatgg acctctgggg tgtgtgtttc tgtgtgtgag tgtgtgtgct gggcagcagg 16860 ctgctgagtg gtagtgatgc tgttaggctg ggggtgggga accagtggct ggaatgggcg 16920 gtaatgtctt tgtcctctac ttgcagatcc actccttata ccgccgcaca ggtgccagct 16980 ttcagaaggc ccagcaagaa tttgctgctg gtgtcttctc caaccctgcg gtgcgaaccc 17040 gagctgccaa tgcagccgct ggggctgctg aaaatgcctt ccgggccccg tgacccctga 17100 ctgggatgcc ctggccctgc tacttgaggg agctgactta gctcccgtcc ctaaggtctc 17160 tgggacttgg agagacatca ctaactgatg gctcctccgt agtgctccca atcctatggc 17220 catgactgct gaacctgaca ggcgtgtggg gagttcactg tgacctagtc cccccatcag 17280 gccacactgc tgccacctct cacacgcccc aacccagctt ccctctgctg tgccacggct 17340 gttgcttcgg ttatttaaat aaaaagaaag aggaactgga actgacatcc ccgtttcctg 17400 aatcttcatt gggaattagg ccttatgaaa gagaaaggag agtgtggagt gaggtgggaa 17460 ggtcggaccc ggctttagtg taaactggga gagagatgag gggcggggcg gtggagcccg 17520 agtggctggc gcaggaagga ggtgggaagt ccacggaaac gcgaaacccg gagacgccag 17580 ggagccctgc tccccacccc tctccattaa tgacggggaa gagccaccgc ctctgccggg 17640 aacgccaagg aatacgcggg cctggagcct gaaaagctgg atggggctca agtggaggcc 17700 caaaggatca ctagcagcct agccagggtc cagagcgagg cagggactgg aggagcgctt 17760 atccgactgc ctcgccctgc cgcgggatcc cccaaccccg acagggtctc agtcccgaac 17820 tacaactccc ggggtgcacc gcgccggccc tcgccgccat gcccctcctt cccgcaccat 17880 ccccattccc atcccccttc tctagtcccc gacctgcggc agccggagct cggggagcgg 17940 agcgtggtgg ggaggggagc gggacaggcg acacaggaga cagcggcgcc gcggcctctc 18000 cccaccaggc ggccccggat cctactggac gccctgaggg cacaccgacc gcgcctctag 18060 agtcacccca cgccgacccc tcccctcttc tctagactta tttccatcct tcccgctttt 18120 accctcccca cccgtccctg ggctccaggc cgccgccccc tcctcactcc tggaccggcc 18180 cttctcggtg cccctcttcc ctagggagat gcgatgagcc ggtgcccccg cgtcctcatc 18240 gtcgccccgg gcacggtgcc cgtccagtgc ccgtggtggg gagggagcac tccgcggtcc 18300 ctccgtgacg cccctcgctt ggcccccccc acagctggcg tccctcggcc atgccccagg 18360 ggacccagcc agggggtggg ctctagagcg agtggggtgg agaggagaaa ggacggggcc 18420 ttgggggcct ctgagatgct cccaagtgcc agggagggcc gagcgaggcg caggcaaccg 18480 ggcagcaggc atgatgccct cgcctagtga ctccagccgc tcgctgacca gccggcccag 18540 caccaggggc cttacccacc tccgcctcca ccgaccctgg ctgcaggccc tgcttacgct 18600 ggggctggtc caagtgctcc tgggcatcct ggtggtcacc ttcagcatgg tggcctcttc 18660 cgtcaccacc accgagagca tcaagaggtc ctgcccgtct tgggctgggt tctcggtgag 18720 ttgggtgcac agttgttggg tgggggaggc tcctcgggcc ccaccctcca caccagctgc 18780 aagtccacat gcttgcctct cctccctctc ctggtcctct gcctccttac agggctgggt 18840 gcatcctgtg gtgaggggct cactcaggag cctccccctg ccaggctgag cctgtgccca 18900 ctctgtcccc agctggcgtt ctccggggtg gttggcattg tgtcctggaa gcggccattc 18960 actctagtgg taggtgccag ggtccagtgc ccactgggag gcaggtgccc agcacgcaag 19020 gggaagccca tttatgacct caagaaggga actggctccc cagttggtgc cagccgggtg 19080 ggcacgaagt tctgtgaagg agggggactc tgtccgtggc agaggagtac tcatgagggt 19140 cccagccctg agtctgcacc ctgttttccc cagatctcct tcttctcctt gctttcggtg 19200 ctctgtgtca tgcttagcat ggctggctct gttctctcct gtaagaatgc tcaactggcc 19260 cgagacttcc aacagtgctc tctggtgaga tttgaggagg gagagctgga aagaactggc 19320 tgggggaggt gtgcaggaca cctcagtttg tgctgactca ggctgcctca ccctccctgc 19380 tccactcagg aaggaaaggt ctgtgtgtgc tgtccctctg ttcccctcct ccggccctgt 19440 ccagagtcgg ggcaggaact gaaagttgcc cctaactcca cctgtgatga agcccgaggg 19500 gccctcaagg tgagcttgca ccctgcaaac atcctcctgg ttctcactct tgcctcccct 19560 gctggggatc tcacaggccc ataatgtgtg gaacttagcc gtctcctgac tcctctcctc 19620 ctttcccttc cccagaacct gctcttcagc gtctgtgggc tcaccatttg tgccgctata 19680 atctgtacac tctctgctat tgtctgctgc atccaaatct tctccctgga cctcgtgcat 19740 acggtgagaa gggagcaggg gccagggcac gcaggtatgg tgggggcagg ggtgtgtgtg 19800 ctgagacttg cctgagggaa caatggctac agatctggct tttgagcacc aggggctatg 19860 ggttatctat tatcctcatc tattggagga atggatgttt agtggggagg atgagaaggg 19920 gagatggcag ggagtgagtt aagtatgtga tgctggtctg ggaccaggag agggtgcttt 19980 agagaatggg actggatggt ggggtagagt caagaaggtc ctatgctggg cacggtggct 20040 cattcctgta atcccagcac tttgagaggc ccaggcaggc ggatcacctg aggccaggag 20100 ttcaagaccc acctggccaa catggcgaaa ccctgtctct attaaaaata caaaaatcgg 20160 gccgggcgca gtggctcgtg cctataatcc cagcactttg ggaggctgag gagggcagat 20220 cacctgagat caggagatcg agactatcct ggctaacatg gtgaaacccc atctctacta 20280 aacatacaaa aaattagcca ggcgtggtgg cgggcgcctg tggtcccagc tactcgggag 20340 gctgaggcag gagaatggca tgaacctggg aggcagagct tgcagtgagc tgagatagtg 20400 ccactgcact ccagcctggg cgacagagca agactccatc tcaaaaaaca aacaaacgaa 20460 atacaaaaat tagccaagtg tggtggcggg tgcctgtaat cccagctact tgggagtctg 20520 aggcaggaaa attgcttgaa ccggggagtc agaggctgca gtgagctgag atggtgccac 20580 tgcattccag cctgggcgac aagagcacag actccgtctc aaaaaaaaaa aaaaaaaaaa 20640 aaaaaaaata tatatatata tatatatata tatatatata cacacaaaat tacaaaaatt 20700 aggctgggct ccgtggctca tgcctgtaat cccagcactt tgggaggcca aggcaggagg 20760 atcaccagat atcaggagtt tgacaccagc ctggccaaca tggcgaaacc ctatctctac 20820 taaaaataca aaaattatcc gggtgtggtg gcgggtgcct gtaatcccag ctactcggaa 20880 gactgaggct ggagaatcgc ttgaacctgg gaggcagagg ttgcagtgag ctgagatgta 20940 gccattgtac tccagcctgg gcgacaagag tgaaacttcg tctcgaaata ataataataa 21000 taataattag ctgggcatgg ttgcacaccc ttataattcc tgctactcag gaggatgagg 21060 catgggaatt gcttgatctt gggaggtggg ggttgcagtg agctgagatc gcgccactgc 21120 actccagcaa cagagtcaga ctctgtctca aaaaaaaaaa gaaggtccta gatggaggtg 21180 aggctaaagg gtggacattc ctgtgaagac acagaatgtg tggagcttct ggatggaggt 21240 ggggccataa agaggaattt gtgggtgggc agggccagag gctagaggta cagggtgacg 21300 gtggggttaa ggagagctga ttttgggtga gggaggggcc agaataagag cttctctcag 21360 gggatagggc cagaaaaaat aatgtagatg agagaggagt ttggggccca ggaggagctg 21420 tattcccaga atccagactt gctgacctgc tcgcttcccc agcagctggc ccctgagcgg 21480 tcagtctcag gcccactggg acctctgggc tgcacgtccc cgcccccagc ccctctccta 21540 cacaccatgc tggacctgga ggaatttgtc ccgcctgtgc ccccaccgcc ctactatccc 21600 ccagagtata cctgcagctc agaaacagat gcacagaggt aaggcctggt ggggtcttgc 21660 tgggggagct aaggaagggg actggggctg ggcctggatt gctggagaga gggatctttg 21720 tggaggggga attatttctc ctacattgac cctcttcctc atctgccagc atcacgtaca 21780 atggctccat ggacagccca gtgcccttgt accctaccga ttgcccccct tcttatgagg 21840 cagtcatggg actacgagga gacagccagg tgagagcaca gcacggcttg gggcgggctg 21900 gggagccggg ttgtagcctg gaaagctgaa caggctgtag cctctggata aagatagtaa 21960 cagtggtcaa ggtctttaca gcaccagcat gcccactgtt gcctttgatc ttccctagag 22020 cctggtgagg tgagtgggtt ggaagctatc atttctgcca tacagacgtg gaagctgagg 22080 ctgcacaatt aagtgacttg tacaaaggga caaggctggt ctggaatcta agtctccaga 22140 gctctgtcta gcacatgggg gtgttcagtg tgtagggctg aacccttgac cctgtgtctt 22200 ctgcaggcca ctctctttga ccctcagctt cacgatggct cgtgcatctg tgaacgagtg 22260 gcctccattg tagacggtga gcagggcgta atgaggggtg gacaagggcg gggctgccag 22320 ggatagctgg ggtgggtaga gacaatagaa ggggaaaaca aggcggagtt ggtggtttgg 22380 ggacatagga gggctgtggc aacttggaac cctggactta tttttctcct ctgagataaa 22440 gctggaggca cagtggcccc tagaggctgg gcttgggaga agaggaactg cctgggcagg 22500 gctaggccag gccaggctgg tgctacacag cgccccctgc cgcccacagt gtccatggac 22560 agcgggtctc tggtgctgtc agccattggt gacctccctg ggggctctag cccgtcggag 22620 gactcgtgcc tgctggagct gcagggctcc gtgcgctccg tggactacgt tctctttcgc 22680 tccatccagc gcagccgtgc cggctactgc ctcagcctgg actgtggcct gcggggcccc 22740 ttcgaggaaa gccccctgcc acggcgcccc ccacgggctg cccgctccta ttcctgctct 22800 gcccctgaag ctccaccccc actgggtgcc cccacagctg cccgcagctg ccaccggttg 22860 gagggctggc cgccctgggt gggaccctgc ttccccgagc tgaggcggcg ggtcccccgg 22920 ggagggggcc gcccagccgc agccccgccc acccgagccc cgactcgtcg cttcagcgat 22980 agctcaggtt ccctcacccc accggggcac cggcctcctc atccggcatc cccaccaccg 23040 ctgctgctgc cacggtccca cagcgaccca ggcatcacga cctccagtga cactggtgag 23100 ccccctcccc gactgcccag gctcaggaga gggtaggcac tgggagttag gtggccagtg 23160 atgcccacca ggattggggc acagttgagg tgggtgagga ggaagaaagg gtgagttcac 23220 tcctctggta gacattctca ggtactcacc tcctagggac agaacatcca tagcttagca 23280 gctaaaaaag gagaattttt tttttttttt gagacggagt ctctggctct gtcgcccagg 23340 ctggagtgca gtggcatgat cttggctcac tgcaacccgt ttcccgggtt caagtgactc 23400 tctcctgctt cagcctgccg agtagctggg actacaggtg tgcgccacca tgaccggcta 23460 atattttttt tttttttttt ttttgagacg gtgtctcgct ctgtcaccca ggctggagtg 23520 cagccgcgcg atctgggctc actgcaactc cgcctcccgg gttcacgcca ttctcccccg 23580 ggttcacgcc attctccttc ctcagcctcc cgagtagtga gtagctggga ctacagatgc 23640 ctgccaccac gcccggctat tttttgtatt tttagtagag atggggtttc accgtgttat 23700 ccaggatggt ctcaatctcc tgacctcgtg atctgcccgc ctcggcctcc caaagtgctg 23760 ggattacagg catgagtcac cgtgcccggg caatttttgt attttttagt agagacaggt 23820 ttcacccttt tggccaggct ggtcttgaac tcctgacctc aagtgatcca cccgcctcgg 23880 cctcccaaaa ggatttattt tttgaaacca gttccacagc tctcagcttg gtccacttat 23940 ctgtcctccc caagcttcag ctgtcacttg ttaacatgta taataatagt acttcacgcc 24000 gggcacggtg gcttgcacct gtaatcccag cactgtggga agctgaggtg ggtggatcac 24060 ctaggtcggg agttcgagac cagcctggct aacatggtga aaccctatct ctactaaaaa 24120 tacaaaaatt agccaggtgt ggtggagcgc gcctgtaatt ccagctacta acgagagagg 24180 ctaaggcagg agaatcgctt gaacctggaa agcaggggtt gccgtgagcc aagatcatgc 24240 cactgcactc cagcctgggt gacagagaca cactccatct caaaaacaca aacaaacaaa 24300 caaaaaacat gtataataac agtacttcag ccataggcat tgtactcgaa gatgctgaga 24360 aagaacagtg gcgggcaagg ctgttcacac ctataatccc agcactttgg aggccaaggc 24420 aggtggatca cctgaggtca ggagttcaag accagcctag ccaacatggt gaaaccccca 24480 tctctactaa aaattgaaaa attagctggg cctggtggtg gacgcctgta atcccagcta 24540 ctagggaggc tgaggcagga gaatcgcttg aacctgggag gcggaggttg cagtgagctg 24600 agatcgtacc actgcactcc ggcctgggca acacagtgag actccatctc aaaaaaataa 24660 gaaaggagat agtactgggg aacgctcagc actgtgcgcc aggtgctgaa caacaccact 24720 gcagtccttg ttgtggtgga ttgtaccatc tagttgctgg ctaatatgga cagagatgct 24780 ggccctttga ttggggatgg agcgtgggag ctgtgaaagc tcctctgggc ttgagttccc 24840 acaggagggt gggcgtgtcc acagaacact tccactcact ccctgtctcc ctttctctct 24900 tctccccagc tgacttcagg gacctttata ccaaagtgct tgaggaagaa gctgcttctg 24960 tttcctctgc agatacaggt caggcatgtg gtttgcgccc cagggatggg gattgggcat 25020 ggctgcccag ccccctctcc accctacaat accattctct tatctctgtc tctctgcagg 25080 gctctgctct gaagcctgcc tcttccgcct agcccgctgc ccttccccca agttgctacg 25140 tgcccggtca gccgagaaac ggcgccctgt gcccaccttc caaaaagttc ccctgccctc 25200 gggccctgca cctgcccact ccctggggga cctaaagggc agctggccag gtcggggcct 25260 ggtcactcgt ttcctccaga tatccaggaa agccccagac cccagtggga ctggagctca 25320 tggacataag caggtaggaa ttcggggagc caggaaagat gtttgggaaa gcgtggagct 25380 tcagattgag ccttattgat gatgcccttt cttgtgtccc tgtccaggtg ccccggagcc 25440 tgtggggccg gcctggccga gagagcctcc accttcgcag ctgcggagat ctgagctcta 25500 gctcttccct gcggcgtctc ctgtctggcc gcaggctgga gcgtggtacc cgcccccaca 25560 gcctcagcct caacgggggc agccgggaga ctgggctctg acctaggctt cttgtcacac 25620 tgaacacatc cagccacagg caccagctgg ttgggaccag cagcccccag catcctcttg 25680 cactggctgg cacaaaaaga aacctgctgt atacccccca aagtgtccct ttccctccta 25740 cctctggggt ctcttgctgc ttgcctctgc tgctctggtc tgggagagct tctgtcctgt 25800 gctgcatggg tatttagact gtgggggaga tgccccttct tatagcactg gaggaggaaa 25860 acaaattctt gtccccctca gaatgagagt ggctctttct gatttgcaag ggcactatgg 25920 tcagggcaaa ggcatggccc aggtgtttaa gtacagggtg acgtgtgcct atgcaatggg 25980 gtggtaaggc aggcacgaag agtccaaaaa atctaggtgg cctctcagct ctgccacctc 26040 tagctgcatg accttgggca agctatgtaa ccccaattgc ctgctccatt aaagactgtg 26100 aaggtagaat gtttgtaaag ctcttaacag tatgtaagcc ttcaataaat ttcagttttc 26160 cccttgtttt cttgatcatt ctctgtcacc agtgaaattt gttctagtgt ctctcatatt 26220 taagaaaact ctttcaggac tgggtatggt ggctcacacc tataatccta gcactttggg 26280 aggccgaagc aagaggatcg cctgagccta ggaattcaag accagcctgg gcaacatagt 26340 gagaccctgt ctctacaaaa aacaaaaaat tagccaggca tggtgggaca cgcctgtagt 26400 cccaactact caggtggcta aggtgagagg atcacttgag cttgggaagt ccaggctgca 26460 gtaagctgtg attgagccac tgcactacag cctgggcaac agagcaagac catgtctcaa 26520 aaaaaaaaaa aaaagaaaaa agaaactttc aagacactct ttccaaccac taattgtaac 26580 tctgctcctc cttttcacag caataggttt tctttttctt ccctccactg ttaaacatcc 26640 attctctcct cacccacccc catcagactc cttcccctat ctttccacag ccactgctct 26700 gaccaaactt tccagtgacc acagtggtgt cagacccagt gaccatttct ctgcctgcat 26760 ctcacttgac ctcgaggcag caattaatac ccataatcag catcttcttg aatttgtccc 26820 tttgaaaagg gaaatattgg ctcttctact ttgtcctgct gaactgctta acattggagg 26880 gccccagggc cctcacctaa gccctctttc ctacctccac tctttctata ggtggcccta 26940 ctactaaagt ccatggcttt aaataccatc tttctatgtg ttaatccatg actccagcct 27000 tgacctccca tgagcgccat ccaactcagc atgtctgctt ggatgtctaa tgggcatttc 27060 agattcaaca tggccacaac tgaactcttg attcccaccc cagcaccggt tatttttcca 27120 ctgttcccat ctcaatggca cctccattac ccatttgcac attccaaaag ctcaggaacc 27180 atggtgactt cttttcccat atccaacaca accaatccta tcctgaattc atccacatcc 27240 caccacctcc ccagctacct agctccagcc atcctctctc cacaacctct gaatcagtct 27300 ttcacttttc ccagcaatcc attctccact cagcaaaatg atgataaagc acgtcacatc 27360 aaggctctgc ctcaatttaa tggcttccca ttgtatttag aatcatctcc aaactcccag 27420 agactatggt cgagctacaa tctggcccac cttctgttcc agccaaattt cctcacagca 27480 caaggacgtt tgcacctgct gttttgccaa gcatgaaacc cttggcccct atatctggtg 27540 ctatcaccta atatcaggtt ttagctccat tctcaccatt tcagtgagca cccaatcccc 27600 atcgcagtca ttctatcaca tagccatgtt tttttttgtt tgtttgtttc attttgtctt 27660 tttttgagac agggtcttgc tttgttaccc aggctggagt gcagtggtgt gatttgggct 27720 cactgcaacc ttccacctcc tgggtcaagc aattctcctg cctcagcctc ccgagtagct 27780 gggattacag gcgcccgtcc ccatgcccgc ccagctaaat tttgtatttt tagaagagat 27840 agggtttcac catgttggcc aggcgggtct caaactcctg acctcaagta atccgcctgc 27900 ctcggtctcc caaagtgctg ggattacagg tgtgactcac cgcgcctggc cacataccca 27960 tggtttcagc atgtatcact atctaaaatt attatttttg tttatatatc tgtgtcgtcc 28020 catagaaggt taaggtccca agatcagaaa cttgctcatt gcagtgggtc taacactcag 28080 taggtcctca acaaacattc gttaagatac taaagtggca gggtggggcc ctgtaaacag 28140 cttcaggagc ttcaggaccc tgtgcttgta ggggcaacgt ggtgccctcc aaggaagaca 28200 gggaggtggg aggagcactg cccagagatg gcgtcaggct gcaagacttc ttgaataatt 28260 cagcatcata acaacccagc ctcaggaagg gatagggcac ggccaggacg aaacattagg 28320 aggcgatgga caatgggatt cccacggggc agcttctgcg cactggacgt tccctaacct 28380 gaggctctct aaagaggaag gttaggaatc ctctgagctt cggtgggctg gactcactgt 28440 gggaattcaa tcgcccccat ccaccaacag tgtgctggcg ggaaaacgcc gacacgcatg 28500 cgtagttctc gcgccggctc ctctctctct ctctctctct ctcgctcgct ctctcgctct 28560 ctcgctctct ctcgctcgct ctctcgctct cgctctctct ctctctccgg ctcgccagcg 28620 acacttgttc gttcaacttg accaatgaga cttgaggaag ggctctgagt cccgcctctg 28680 catgagtgac cgtctctttt ccaatccagg tccgcccgac tccccagggc tgcttttctc 28740 gcggctgcgg tgatcggtcg ggctgcatcc tgccttcaga gtcttactgc gcggggcccc 28800 agtctccagt cccgcccagg cgcctttgca ggctgcggtg ggatttcgtt ttgcctccgg 28860 ttggggctgc tgtttctctt cgccgacggt aggcgtaatg aatatttcga cctttggatc 28920 ttagctgtcc cctccctgcg ttcgcactta acctttttca ccattattat tattattgtt 28980 attattatta ttttttgagg gagtctcgcc ctgtcgccca ggctggagtg taatggcgcc 29040 ttcttggctc actgcaacct ccgcctcccg ggttcaggcg attctccgac ctcagcctcc 29100 caagtacgtg ggattacagg cacccgccac cacgcacggc taattttttg tatcttttag 29160 tagagacggg gtttcaccat gttggtcagg ctggtctcca attcctgacc tcgtgatccg 29220 cccgcctcgg cctgccaaac agctgtgatt ataggcgtga gccaccgcgc ccggccaacc 29280 atcattatta tttttaacgg taaggatggt cagattttac taatgaagaa gagattataa 29340 aatcttcaag tctttatatc cacttgcttt ttgaggggtg gagtgggaag aaggttatgt 29400 aattcatacg ttcttcagag atgtgacaaa cattcacgga gccggacgac gtcgggttgg 29460 attcgcactg gagctgcaga tgggtgccag gatggactgg tccctaccct ccgcttgaac 29520 ctaggaggcg gaggttgcag tgaaccgaga tcgtgccact gcactccagc ctgggtgaca 29580 gagatactcc gtctcaaaaa aaaaaacaaa acaaaaaaca agcggactgg gcgcagtgcc 29640 tcaccctgta atcccagcac tttgcaaagc caaggcggga ggatcctttg agtttaggag 29700 tttgagacca acctgcgcaa cacagtaaga ccccgtctct acaaaaaata cagaaattag 29760 ccaggtgtgg tggtgtgcgc ctatagtccc agctattctg gaggctgagg tgggaggatt 29820 gcttattctg gaggcagagg ttgcactgag ccgaaatcaa gctactacac tccatccagg 29880 gcaacatacg gagaccctgt ctcaaacaaa caaacaaaaa attgctcagt acctggccaa 29940 aaaagaagag gctcactatg cagaggggaa gtggaaggag atgtttggac ttctaaactc 30000 aatagagcag gagaggcaaa tgtagaatgt gctcaggaaa tatctgtgag atgaatgaac 30060 ttgagggaag taaggtacta gatattacct gccctaccca gaacaaatcc tgtgcaatgt 30120 ttccttgaaa agtgagaagt ctggaagggg tggctactga catagtgaag caactagttc 30180 aattctacaa cttgacagct accctgtgcc aggctatcta cgaggatact tagaatgcat 30240 aagacattcc ttcaaggaac tccaggaaca gaggcctgac atgttgcaat gtttagtgtc 30300 aagcagtgta ctagagacac attatcacac tcaaacctca caacaattct gtgaggtagg 30360 agttatcact ccccttttat agatgaaaca gaggcttaga gtgattgatt tattgaaagt 30420 caaacagcca gtaaatggtg tagccaggat tccaaacttg ctgtctcact gagactgtac 30480 ttaattactg gagggaccgg gtgtggtggc tcattgctat aatcccaaca ccttgggagg 30540 ctgaggctgg tggatcacct gaggtcaggg gttcgagacc agcctggcca acatggtgaa 30600 accccatctc tactaaaaat acaaaaatta gctgggcatg gtggtgggct cctgtaatcc 30660 cagctactca ggaggctgag gcagggcaat tgcttgagcc gagatcacac tgcactccag 30720 cctgggcaac agggcaagac tctgtctcaa aaccaaaaaa aaaaaaatta ctggaggaac 30780 ctagaagaag aaatgatcaa ttttgcttgg agtgtatcta gaaagacttc actgagatca 30840 tttaaagaac aaaaaggatg gctggggtcc aggcagtggc tcatgcctgt aatcccagca 30900 ctttcggata ccaaggcagc agatcacctg aggtccagag tttcagacca gcctggccaa 30960 catagtgaaa ccccatctct actaaaaata aaaaaattag ctgagcatgt tggagggcac 31020 ctgtaatccc agctacttgg gaggctgagg caggagaatc actcgaaccc aggaggtgga 31080 ggttgcagtg agccaagatc acgccactgc actccagcct gggcaacaga gtgagactct 31140 gtctcaaaaa acaacaacaa caaaaaatac aaacaagaga caagtagttc ccaggtgcct 31200 accaagtggt caggcactgc acttacctca ctgactgcag taaccaccct ttgaggttgt 31260 ggcattgctc cattttccag gcaaggaaat gggctgagag ctgggattag tcaggtcatg 31320 actgtgtgtg ccactcccgc taaatctcat ttgatgtggt tcatgaggcc acaccatgga 31380 cagcttcctc cttgtgtcca ctgaggatat ggctttgtac aacactttgg tttttgaacg 31440 actttacaaa cctccctgtc ttgtgaggaa ggaagaacag ttattaccat ctgcatctga 31500 tgatgaaaca agggacgctg cagaggagcc gcactgacca ctccctccct ccagtcctgt 31560 catcccactg ccagtgtccc accctcttgt gccctgcact tcactggcta ataacccccc 31620 tcactttttc ctctgtgaag ccatcctgga taattcccca cccacgaatg gtccctcctc 31680 atctcagaga gctctccatg cacacctgtt accgtttctg tctttatctg taaatatctg 31740 tgtgtctgac ttccatgcct cacacacctc tatagggcaa agactgtctt aaacatcttg 31800 gtagtgtcag tattttgcac agtgaagttt ttttttttaa attatatcag ctttatttgt 31860 acctttttga catttctatc aaaaaagaag tgtgcctgct gtggttccca tcctctggga 31920 tttaggagcc tctaccccat tctccatgca aatctgtgtt ctaggctctt cctaaagttg 31980 tcacccatac atgccctcca gagttttata gggcatataa tctgtaacag atgagaggaa 32040 gccaattgcc ctttagaaat atggctgtga ttgcctcact tcctgtgtca tgtgacgctc 32100 ctagtcatca catgacccat ccacatcggg aagccggaat tacttgcagg gctaacctag 32160 tgcctatagc taaggcaggt acctgcatcc ttgtttttgt ttagtggatc ctctatcctt 32220 cagagactct ggaacccctg tggtcttctc ttcatctaat gaccctgagg ggatggagtt 32280 ttcaagtcct tccagagagg taagagagag agctcccaat cagcattgtc acagtgcttc 32340 tggaatcctg gcactggaat ttaatgaatg acagactctc tttgaatcca gggccatcat 32400 ggctctttga gcaaggcaca gatggaggga ggggtcgaag ttgaaatggg tgggaagagt 32460 ggtggggagc atcctgattt ggggtgggca gagagttgtc atcagaaggg ttgcagggag 32520 agctgcaccc aggtttctgt gggccttgtc ctaatgaatg tgggagaccg ggccatgggc 32580 acccaaaggc agctaagccc tgcccaggag agtagttgag gggtggagag gggcttgctt 32640 ttcagtcatt cctcattctg tcctcaggaa tgtcccaagc ctttgagtag ggtaagcatc 32700 atggctggca gcctcacagg attgcttcta cttcaggcag tgtcgtgggc atcaggtgag 32760 tgagtcaagg cagtggggag gtagcacaga gcctcccttc tgcctcatag tcctttggta 32820 gccttccagt aagctggtgg tagactttta gtaggtgctc aataaatcct tttgagtgac 32880 tgagaccaac tttggggtga ggattttgtt ttttttcttt tgaaacagag tcttactctg 32940 ttgcctgggc tggagtgcag tggtgcaatt ttggctcatt ccaacctctg cctcccagat 33000 tcaagcgatt ctcttgcttc agcttcccag gtagctggga ttacaggcgg ccaccactac 33060 gcccagctaa tttttgtatt tttagtagag acggggtttc accatgctgg caaggcaggt 33120 ctcaaactcc tcacctcagg tgatccgccc acctcggcct cctaaagtgc taggattaca 33180 ggtgtgagcc cctgcgcccg gccaaggggt gaggaatttt gaaaccgtgt tcagtctctc 33240 ctagcagatg tgtccattct ccatgtcttc atcagacctc actctgcttg tactccctcc 33300 ctcccaggtg cccgcccctg catccctaaa agcttcggct acagctcggt ggtgtgtgtc 33360 tgcaatgcca catactgtga ctcctttgac cccccgacct ttcctgccct tggtaccttc 33420 agccgctatg agagtacacg cagtgggcga cggatggagc tgagtatggg gcccatccag 33480 gctaatcaca cgggcacagg taaccattac acccctcacc ccctgggcca ggctgggtcc 33540 tcctagaggt aaatggtgtc agtgatcacc atggagtttc ccgctgggta ctgataccct 33600 tattccctgt ggatgtcctc aggcctgcta ctgaccctgc agccagaaca gaagttccag 33660 aaagtgaagg gatttggagg ggccatgaca gatgctgctg ctctcaacat ccttgccctg 33720 tcaccccctg cccaaaattt gctacttaaa tcgtacttct ctgaagaagg tgaggaggaa 33780 ggggacaaga tgacatagag ccattgaaac ttttcgtttt tcttttcttt ttttaaaatt 33840 tttttgaggc agaatctcac tctgcccatt ctgtcggcga gacaggagtg cagtggtgtg 33900 atctcccctc acagcaacct ctgcctccca ggctatagtg attctcctgc ctcagcctcc 33960 tgagtagctg gaattatagg cgtgcgccac taccacctgg ctaatttttg tatttttagt 34020 agagacaggg tttcatcatg ttgaccaggc tagtcttaaa ctcctgacct caaatgatat 34080 acctgccttg gcctcccgaa gtgctggaat tacaagtgtg agccaccgag cccagcagac 34140 acttttcttt tttctttttt tttttttgag acagagtctc gcactgtcac ccaggctgga 34200 gtgcagtggc acaatctcag ctcactgcaa cctccacctc ccgggttcag gtgattctcc 34260 tgtctcagcc tctcgagtac ctgggattac aggtgcctgc caccacgccc ggctaatttt 34320 ttgtattttt agtagagaca gggtttcact atgttggcca ggatgattgc gaactcctga 34380 cctcgtgatc tgcccacatc ggcctcccaa agtgctggga ttacatgcgt gagccactga 34440 cacttttctt tgccctttct ttggaccctg acttctgccc atccctgaca tttggttcct 34500 gttttaatgc cctgtgaaat aagatttcgc cgcctatcat ctgctaactg ctacggactc 34560 aggctcagaa aggcctgcgc ttcacccagg tgccagcctc cacaggttcc aacccaggag 34620 cccaagttcc ctttggccct gactcagaca ctattaggac tggcaagtga taagcagagt 34680 cccatactct cctattgact cggactacca tatcttgatc atccttttct gtaggaatcg 34740 gatataacat catccgggta cccatggcca gctgtgactt ctccatccgc acctacacct 34800 atgcagacac ccctgatgat ttccagttgc acaacttcag cctcccagag gaagatacca 34860 agctcaaggt aggcattcta gctttttcag gccctgaggg ccctgatgtc tgggggttga 34920 gaaactgtag ggtaggtctg cttgtacaga cattttgtcc cctgctgttt tgtcctgggg 34980 gtgggagggt ggaggctaat ggctgaaccg gatgcactgg ttgggctagt atgtgttcca 35040 actctgggtg cttctctctt cactaccttt gtctctagat acccctgatt caccgagccc 35100 tgcagttggc ccagcgtccc gtttcactcc ttgccagccc ctggacatca cccacttggc 35160 tcaagaccaa tggagcggtg aatgggaagg ggtcactcaa gggacagccc ggagacatct 35220 accaccagac ctgggccaga tactttgtga agtaagggat cagcaaggat gtgggatcag 35280 gactggcctc ccatttagcc atgctgatct gtgtcccaac cctcaaccta gttccacttc 35340 cagatctgcc tgtcctcagc tcacctttct accttctggg cctttcagcc ttgggcctgt 35400 caatcttgcc cactccatca ggcttcctgt tctctcggtc tggcccactt tctttttatt 35460 tttcttcttt tttttttttt tgagaaggag tctctctctc tgtcacccag gctggagtgc 35520 tgtggcgcca tcttcactca ctgtaacctc tgcctcctga gttcaagcaa ttctcctgcc 35580 tcagccttcc aagtagctgg gattataggc gcctgccacc aggcccagct gatttttcta 35640 tttttagtag agacggggtt tcgccaggct gttctcgaac tcctgaactc aagtgatcca 35700 cctgcctcgg cttcccaaag tgctgggatt acagtgtgag ccaccacacc cagctggtct 35760 ggtccacttt cttggccgga tcattcatga cctttctctt gccaggttcc tggatgccta 35820 tgctgagcac aagttacagt tctgggcagt gacagctgaa aatgagcctt ctgctgggct 35880 gttgagtgga taccccttcc agtgcctggg cttcacccct gaacatcagc gagacttcat 35940 tgcccgtgac ctaggtccta ccctcgccaa cagtactcac cacaatgtcc gcctactcat 36000 gctggatgac caacgcttgc tgctgcccca ctgggcaaag gtggtaaggc ctggacctcc 36060 atggtgctcc agtgaccttc aaatccagca tccaaatgac tggctcccaa acttagagcg 36120 atttctctac ccaactatgg attcctagag caccattccc ctggacctcc agggtgccat 36180 ggatcccaca gttgtcgctt gaaacctttc taggggctgg gcgaggtggc tcactcatgc 36240 aaacccagca ctttgggaag ccgaggcggg tgatcacctg aggtcaggag tttaagacca 36300 ccctggccaa cgtgttgaaa ccctgtgtct actaaaatac aaaaaaaaaa aattatctgg 36360 gcatgatggt gggtgtctgt aatcccagct actcaggagg ctgagaaggg agaatcagtt 36420 gaacccggga gatggtggtt gcggtgagcc gagatcgcgc cactgcactc cagcctggga 36480 ggctgagcga gactccatct cgaaacaaaa caaaacaaaa ctatctaggc tgggggtggt 36540 ggttcatgta tgtatgtgta tatacatata tatgtgttta tatgtatata tatatacaca 36600 cacacacata catacacaca catacacaca caaattagct gggtgtggca cccgtgtagt 36660 cccagctact caggaggcta atgtgggagg atcagttgac cctaggaagt caaggctgca 36720 gtgagtcgtg attgcgccac tgtactccag cccgagtgac agagtgacat cctgtctcaa 36780 aaacaaaaaa aaatctcccc aaacctctct agttgcattc ttcccgtcac ccaactccag 36840 gattcctaca acaggaacta gaagttccag aagcctgtgt gcaaggtcca ggatcagttg 36900 ctcttccttt gcaggtactg acagacccag aagcagctaa atatgttcat ggcattgctg 36960 tacattggta cctggacttt ctggctccag ccaaagccac cctaggggag acacaccgcc 37020 tgttccccaa caccatgctc tttgcctcag aggcctgtgt gggctccaag ttctgggagc 37080 agagtgtgcg gctaggctcc tgggatcgag ggatgcagta cagccacagc atcatcacgg 37140 taagccaccc cagtctccct tcctgcaaag cagacctcag acctcttact agtttcacca 37200 aagactgaca gaagcccttc ctgtccagct ttccccagct agcctgccct tttgagcaac 37260 tctggggaac catgattccc tatcttccct ttccttcaca ggtctgcaca cctcattgcc 37320 ccttttgcaa ctactgaggc acttgcagct gcctcagact tctcagctcc ccttgagatg 37380 cctggatctt cacaccccca actccttagc tactaaggaa tgtgcccctc acagggctga 37440 cctacccaca gctgcctctc ccacatgtga cccttaccta cactctctgg ggacccccag 37500 tgttgagcct ttgtctcttt gcctttgtcc ttaccctaga acctcctgta ccatgtggtc 37560 ggctggaccg actggaacct tgccctgaac cccgaaggag gacccaattg ggtgcgtaac 37620 tttgtcgaca gtcccatcat tgtagacatc accaaggaca cgttttacaa acagcccatg 37680 ttctaccacc ttggccactt caggtgagtg gagggcgggc acccccattc cataccaggc 37740 ctatcatctc ctacatcgga tggcttacat cactctacac cacgagggag caggaaggtg 37800 ttcagggtgg aacctcggaa gaggcacacc catccccttt tgcaccatgg aggcaggaag 37860 tgactaggta gcaacagaaa accccaatgc ctgaggctgg actgcgatgc agaaaagcag 37920 ggtcagtgcc cagcagcatg gctccaggcc tagagagcca gggcagagcc tctgcaggag 37980 ttatggggtg ggtccgtggg tgggtgactt cttagatgag ggtttcatgg gaggtacccc 38040 gagggactct gaccatctgt tcccacattc agcaagttca ttcctgaggg ctcccagaga 38100 gtggggctgg ttgccagtca gaagaacgac ctggacgcag tggcactgat gcatcccgat 38160 ggctctgctg ttgtggtcgt gctaaaccgg tgagggcaat ggtgaggtct gggaagtggg 38220 ctgaagacag cgttgggggc cttggcagga tcacactctc agcttctcct ccctgctccc 38280 tagctcctct aaggatgtgc ctcttaccat caaggatcct gctgtgggct tcctggagac 38340 aatctcacct ggctactcca ttcacaccta cctgtggcgt cgccagtgat ggagcagata 38400 ctcaaggagg cactgggctc agcctgggca ttaaagggac agagtcagct cacacgctgt 38460 ctgtgactaa agagggcaca gcagggccag tgtgagctta cagcgacgta agcccagggg 38520 caatggtttg ggtgactcac tttcccctct aggtggtgcc aggggctgga ggcccctaga 38580 aaaagatcag taagccccag tgtcccccca gcccccatgc ttatgtgaac atgcgctgtg 38640 tgctgcttgc tttggaaact gggcctgggt ccaggcctag ggtgagctca ctgtccgtac 38700 aaacacaaga tcagggctga gggtaaggaa aagaagagac taggaaagct gggcccaaaa 38760 ctggagactg tttgtctttc ctggagatgc agaactgggc ccgtggagca gcagtgtcag 38820 catcagggcg gaagccttaa agcagcagcg ggtgtgccca ggcacccaga tgattcctat 38880 ggcaccagcc aggaaaaatg gcagctctta aaggagaaaa tgtttgagcc cagtcagtgt 38940 gagtggcttt attctgggtg gcagcacccc gtgtccggct gtaccaacaa cgaggaggca 39000 cgggggcctc tggaatgcat gagagtagaa aaaccagtct tgggagcgtg aggacaaatc 39060 attcctcttc atcctcctca gccatgccca gggtccgggt gcctggggcc cgagcaggcg 39120 ttgcccgctg gatggagaca atgccgctga gcaaggcgta gcccaccatg gctgccagtc 39180 ctgccagcac agataggatc tggttccggc gccggtatgg ctcctcctca gtctctgggc 39240 ctgctggtgt ctggcgttgc ggtggtacct cagctgaggg tcaaggaagg aaggtgtgtt 39300 aggagaacta gttcttggat ccctgcccac tctccccagg gctgcccctc ccatctgccc 39360 cttacctcca tcccagggga agtagagact gagaatgtgg gtacaatagg cacagaggtt 39420 gtgcagccca cgcaggtgga cctgcagctt cccactgggc agctttgcct gcagcagcag 39480 ggccaagtag ctgaagacga aggcgtccaa ggaggcaggg ctggagcaga gagagaaggg 39540 tgggatggag gagaaccact ggggtagaag gggtaaagat ggagctggag gaagagtcag 39600 ccttgggagg tgggctctgg gcagcaggcg gccaccaggg aaggacagga cacacagttc 39660 tagacctggt atggggagag atccccaggt ggcgccagct ggccctgaat agggctctat 39720 cccagggctg cataaagggc acactcagtg ccccacagct cttcaggccc ttcctgtgcc 39780 tggctgccct cccaccctac ccttttgtac ctctgagaag gctctggccc cacgcacagc 39840 cccactgtca ccagggccag tatctgtctc agggacctcc tatccagagc ctgagccagc 39900 cccagcccca gccccagctc cagctgctcc atctgaacct gtatcttctt ccaagccacc 39960 cattaccctc ttggagtcag actcacgcat ctccaaagaa gaacttttga gagcccaggc 40020 gctgagagag cagggtcaga cactcccgag cctctcggta cagctgtagg ggcgacacag 40080 gtaggcttgc agctgcggga acagtgccac ctccgcacct aagcactccc attcctggcc 40140 agcatccttg gggctcatct catacaatag cccccggtct cagagctacc tccttctcca 40200 gctcttcctc gtcctcaggc ctgtgctccc cagtcagcag ctgtagccgt tccatgtact 40260 gccgctgcat gcggccaggc aggaagaagt tgaggggaaa gggcatagcc tctgcatacc 40320 acttccgggt cacttctacg tagttcttgg tgtctatcca aaaagtatgt acctggattg 40380 ggtgggcagg aagaaacagg caggtctgag ccagtgcacc tgtctgattc aaggtgggct 40440 tctgacctcc atgctctcct gagtctctgt gtgggtctgt gtgttcccgt cccctccccg 40500 gctggccatg gatgctggga ggtctgggca cactcaccag caccgggatc aacttctcct 40560 ccaggagaga catgaaggcc agggtgtctg ccccttgctg agctgacaga tcataatcag 40620 cattgtactt ctgtggagga aatatccatg gcgtggacgc tggggagctg caagggcact 40680 tcaccaggga ggaaggagtc ctgtctggta cccccctcac tggcctctga gtgcagtgga 40740 ggtacagcaa ggaacttttc ctgccaaggc ccccttgcct gggcccagcc agtagcctgt 40800 tgctgttggc aaaaagcctg ggccttggag cccgctggcc gtcaaggtcc tgggcccatt 40860 gagaagaagg aagaaaggtt gggccgcaaa ctaggagcag ctcccagaat ttccatggaa 40920 agctggaaca atgcctgctg acagcaactt tctaacagta actttcccga cccagacacc 40980 acaaagctag cacaacggag ctcagatgca ggctaggact cggtccatgc ctcaggaacc 41040 agggaaagcc atcctcacac tccctggatc cagggaaccc acgcccaggg ccccccagct 41100 tgttccctca gtgcccagct cttggctatt tctttcactt cattccatcg cccagacacc 41160 attaccacat acacattcca tccatacccc caggtctcag cctgccctac cttcccaggc 41220 tccagtccct gttcctcagc atcccccacc acatcctgag taagctttgt ccccagataa 41280 cctcttcagc atgatcctta aatctcccta agcctcagtt tctcccctgt ggaatggggg 41340 taagaatctc tttctctgaa tgcccctgtg ttaggaaata atttagaata cttcggaaac 41400 aaaaagctct gttcacacct aagcaatcag ggcagtggcc tggccttgcc aggaacttag 41460 gcttttatct ggatcctctt tccaggcctc tcaattaatt ccccaggtcc ttaacctttg 41520 ggaaattaga aattaggaag agtgtcccac ttctgacact gtgttccctc ttggaacctg 41580 accgtcaatg ctagaagaac ccttggaaaa catgctggcc cagccctcta gttttacaaa 41640 taagggagtg cacagccctg agaggttaca tggcctgccc aagatcacgc agtcaatggc 41700 agagtaaaga gcatagccta ggcctcccca ctcctctagt aatgctcttt catcttctcc 41760 aacctggctc taagccttgt ccatcctgag ccccatatct agcccaacct agtccctgaa 41820 aacaagaagt ggcccttaga aatctctctc cagtcccact atcagaggcc aactgctgtc 41880 ttccagtctc cttcagcctg tgctcctctc cctccctgac tgacaggcag aaggtaccgt 41940 gcctctggat atccccacag tgccctgagc tgcatctctt gccgactgct ttaatacatc 42000 acagtgacat tgtgtgtgtc tctgccacca gactattgct ccttgatgct ctgggtcacc 42060 tgcatctagc atggcatata tctagtgctc aataaatgtg tattgtacgg aattgactga 42120 acttctctca ctggcagccc cctctatcca aatcacccac ctctttttga aggtgggtga 42180 tgatcttgtg tggtactgag gtgacctctc catgactggt ccaaagggca ggcagggttc 42240 ctgatactga gagaaaagta taccaaccag gaccttagct gcctatccat acgtagttgc 42300 aacacattcc tgcctatctc ctgcttctcc tcttgtacac acccttcctc acccccaagg 42360 gatactgggt acctgaaggg ctctgccagg ggttgctgat cttgtgctat atggtgcaca 42420 agaaactttt aagaaaaaag aaactttcaa gacacacttt ccaaccacga attctatctc 42480 tgctcctttt catagcaata ggttttcttt ttcttccctc cacacttaaa catccattct 42540 cttatcaccc acccccatca gactccttcc cctgtgtttc ttcagccact gctctgacca 42600 aaatttgagt gaccaaaagt ggtgtcagac ccagtgacca tttctctgcc tgcatttcac 42660 ttgaccttga agcagcaatt aatctccata atcagcatct tcttgaattt ttccctttga 42720 ggacattgct cttctacttt gtgctctggt tatcctttac aaacttttac acctctcctg 42780 aactggttaa cagtagaggg ccccaagggt ctcacgtaag ccttctttgt ttttgttttt 42840 tttcttttct tttatttttt atatattttt ttgagacgga gtcttgctct gttgcccggg 42900 ctggagtgca gttgcacgat ctcggctcac tgcaagctct gcctcccagg ttcatgctat 42960 tctcctgcct cagcctcccg agtagctggg actacaggtg cctgccacca tgcctggcta 43020 attttctgta tttttaacag agacagggat acaccatgtt agccaggatg gtctcgatct 43080 cctgacctcg tgatctgccc acctcagcct cccaaaatgc tgggattaca ggcgtgagcc 43140 actgctccca gccgtcattt ttattttatt ttatttattt ttttgagatg gagtcttgct 43200 cttttgccag gctggagtgc atggtgcgat ctcggctcat tgcaaccccc gcctcccagg 43260 ttcaagcgat tctcctgcct cagcctcctg agtggctggg actacaggtg cctgtcacca 43320 tgcctggcta attttctgta ttttagcttg agacacggtt ttcaccttgt tagccaggat 43380 ggtctcgatc tgtgagcctc gtgatctgcc tgcgtcggcc tcccaaagtg ctgggattag 43440 caggcagtga gccactgcac ccggccatca attttttttt tttttaaatg gagtcttgct 43500 ctgtcaccca ggttggagtg taacagtgca atcttggctc attgcaacct ccgcctcttg 43560 ggttcaagcg attctccagc ctcagcctcc tgagtagctg ggactacagg tgcatgccac 43620 cacacccggc tagtttttgt atttttagta gagacggggt ttcaccatgt tgtccaggat 43680 ggtctcaaac tcctgacctc aaatgatgtg cctgccttga ccttccaaag tgctgggatt 43740 agaggcgtga accacattgc ccaccgtaag ccctcttttc tacttccact ctttctgtag 43800 gtggccctac tactaacgtc catggcttta agtaccatct ttctatgtgt taatgcataa 43860 gtccagcctt gacctctctt gagcgccatc caactcagca tatctggttg gatgtctaat 43920 gagtatttca aattcaacat ggccacaact gaactaactg aactcttttt tttttttagg 43980 cagagttttg ctcttgttgc ccaggctgga gtgcaatggc gagatcttgg ctcactgcaa 44040 cctctgcctc cagggttcaa gcgattctcc tgcctcagcc tcccgagtag atgggattat 44100 aggccccgct acccggctaa tgtttttgta tttttagtag agacagggtg ttgccatatt 44160 gaccaggctg gtctgcaaat cctgacctca ggtgatcccc ctgcctcggc ctcccaaagt 44220 gctggaatta caggcgtgag tcactgcccc ggccacacaa ctgagctctt cattcccacc 44280 ccagcaccgg ttatttttcc actgttccca tctcaatggc acctccatta cccatttgca 44340 cattccaaaa gcccaggaac catggtgact tcttttccca tatccaacac aaccaatcct 44400 atcttgaatt catccacgtc ccaccacctc cccagctacc tagttccagc caccctctct 44460 ccacaacctc tgaatcaatc tttcactttt cccagcaatc cattctccac tcagcaaaat 44520 gatgataaag cacgtcacat caaggctctg cctcaattta atggcttccc attgtattta 44580 gaatcatctc caagctctca gagactatgg tcagctacaa tctggcccac cttctgttcc 44640 agccaaattt cctcacagca caaggacgtt tgcacctgct attttccaag cacgaaaccc 44700 tcgggcagat atatctggtg ctgtcaccta atttcaggtt ttaactccac tctcaccatt 44760 tcagtgagga cctaatcccc atcgcagtca ttctatcaca tagctttatt ttattttatt 44820 ttattttttt ttgagataca gtctggctct ctcacccagg ctggagtgca gtggtgtgat 44880 ctgggctcac tgcaaacttc catctcctgc gttcaagcga ttctcctgcc tcagcttccc 44940 gagtagctgg gattacaggt gtctgccatc acgcctgact aagttttgta ttttcagtag 45000 agacggggtt ttgccatgtt agccaggctg gtctcgaact ccttgacctc aagtgatcca 45060 cctgcctcag cctcccacaa tgttggattt acaggcgtga gccactgctc ccggccacat 45120 agccatgttt taagcatgta tcactatcta aaattatttt ttgtttatac gtttgtgtcg 45180 tcctgtagaa tgtaaggtca caagatcagg gacttgctca ttgcactggg tctaacacac 45240 agtgcttcaa caaacactcg ttaagatact aacgtggcag agtggggcct tgtaaacagt 45300 ttcaggaccc tgtgcttgta agagcaacgt ggtgccctcc caaggaagac agggaggatg 45360 caggagcact gcccagagat ggcgtcaggc tgcaagacat cttgaataat tcaccatcgt 45420 aacaacccag cctcaggaag agatggggca aggccagaac gaaacattag gtaagaggcg 45480 gtggacaatg ggattcccac agggcagctt ttgggcactg gacgttccct aacctgaggc 45540 tctctgaaga ggaaggttag gaatcctctc agcttcggtg ggctggactc actgtgggaa 45600 ttcaatcgcc cccccccacc cactaagggt gtgctggcgg gaaagcgctg agacgcatgc 45660 gtagttctcg cgtctggcac ccgctccctt tccaatacgc ttgcgccccg tctgtgctac 45720 ggatggtcag ggagagttgt ccgtcttcaa atggaccaat gagacttgtg gaggggctct 45780 gagtcccgcc tctggatgag tgaccgtctc ttttccaagt gaggcccgcc cgcctcccca 45840 gggctgcttt tctcgcggca cgggtggtgg ggctgcttct tgacttccgc gcctagtgcg 45900 cagggcccca ttctccagtc ccgcccacgc gcctttggag gctgcggtgg gatttccttt 45960 tgccttcggt tggggctgct gtttctcttc gccgacggta ggcattataa atatttcgcc 46020 ctttgaattt tagctctccc ctcccggcgt tcgcacttag cctttttcat cattatcatt 46080 atttttaatg gtaaggatgg tcaaatttta ctaatgaagc gattataaaa tcttcaagtc 46140 tttgtatcca cttgcttttt gagggctgga gtgggaagaa aggtatataa ttcattcatt 46200 cttcggacat gtgacaaacg ttcacggagc gcggcaacga gcgccggtgt cgcgatgcgc 46260 actggggctg cacatgggag ccaggatgga ctggactggt ccctgccctg cccgctgacg 46320 attggcaggc cactgccttt gatgagctgg gcgctataac tgccattaag ccatttgtac 46380 aattaatcac aacagtgata agagcgacaa aggagctatt cgggtggctg aggcggagga 46440 tcttttgagc ctaggagttc gagaccagcc tggggaatag agcgagatcc tgtctcaaaa 46500 aaagggggag aaaaagtgac aaagaagttg tgagggctat gagtttgcgt tagaggaggt 46560 gtgtgaggtg gggaggcggc agggggcgcg gttgttctta gagaaagtga catccgggct 46620 aattttgaaa gaataagtgt taactaggct aagcggtggg aaagagtagt gtgtgctgaa 46680 ggaagggaag aggaacctgg caagttcatg gcaggcctgt aattggatgc tggtctccct 46740 ccacacttga ctcctacagt ctgatttcta cacagcaccc aaagtgatct cttaaaaata 46800 cacatgtgat cttgtcactt cccagcacca aactctacag tgaatttcca tcttagaaca 46860 aaattcagac tccttaccat ggccaccaag accctacaca atctggcctc ccaatttcct 46920 tttccaaggt caccttttac cactatccat ctcactcaca ctgctccagc actctctatg 46980 cttttatttt tctttcttcc tctttctttc tttctttctt tttctttttc tttctttctt 47040 tccttccttc tctctctctc tctttctttt cttttctctt tctttttttt ttttttgaga 47100 tgcagtcttg ctctgtcacc caggtgtgtg atcttggctc actgtcaacc cagagcagtg 47160 ggggtgatct tggctcactg cagcctccgc cttccaggtt caagcaattc tgcctcagcc 47220 tcctgagtag cagggattag cgccatcagt cccagctaat ttttgtattt ttagtagaga 47280 tttcatcatg ttgtccaggc tggtctcgaa ctcctgactt caagtgatct gcccatctca 47340 gcctcctaaa gtgctgagat tacaggcagg agccaccaca cctggctcag tatttgtttt 47400 atttttgttg tgtttattta tttagagaca aggtcttgct ctgttgctca ggctggagtg 47460 ctgtggcagg aacacagctc actgcagcct ccactacctc aattcaggcg atcctcccac 47520 ctcagctgag actacaggtg tgcatcacca tgcctggtta attttttcgt tttaccatgt 47580 tggccaggtt tgtctcgaac tcttgggctc tgctgtcctc ctaccttagc ctcccaaagt 47640 gctaggattg taggcgtgag ccactgtgcc cagctggtgt tcagtatttg aatccatatt 47700 tcctgtagcc gcaaccaaag ttccactgtt aggtctcact ttgactttaa taattgtgtt 47760 caggctgggc acactggctc aagcctgtaa tctcagcagt ttgggaggcc gaggtgggtg 47820 gatcacatga ggtcaggtgt ttgagaccag cctgtccaac atggcgaaac cctgtctcta 47880 ctaaaaatac aaaacattct ccgatcgtag tggcgggcgc ctgtaatccc agctacttgg 47940 gaggctgaag gaggagaatt gcttgaacct gggaggcaga ggttgcagtg agcggagatc 48000 acgtcattgc actccagcct gggctacaga gcgagactct gtctcaataa gtaaataaat 48060 aaataaataa ataaataaat aaataaataa ttgtgttcgg agtcagcatc attcttcctg 48120 aagttcacca ctcctttgcc aagaacactt cctgaaacac tgacaagcag gaccttgaat 48180 aatggggtat ggttggtaac aactcactca ttcaacaaac attgagcacc tattttgtgc 48240 ttgcctctaa atgaagagct ggttgtatta tttatttttt taggtgacag ggctttccct 48300 atgttgccca ggttcgtctc aaactcctgg gctcaaaaga tcctcatctt ctcaagtggt 48360 tgaatataca cgctccagcg accatgcctg gctgaatgaa gagctttgag attttgaaga 48420 aacaggaacc atgaaatttg ctttgcaact gtttgcaacc tttaaggaag actgaaaagg 48480 cattcctgaa gcatgtgaga agcagtctgt gtgacctgat gactcagaac tgcttggaat 48540 ttagattagg acagatatga gcttaggctt cactctgcca catatttaac ttctctaagt 48600 cttagttttc ttttcttttt tttttttttt gagatggagt ctcgctctgt cacccaggct 48660 ggagtgcagt ggcacgatct tggctcactg caagctccgc ctcccgggtt cacgccatcc 48720 tcctgcctca gccacccgag tagcggggac tacagtcgca caccgccacg cctggctaaa 48780 tttttgtatt tttagtagag acgggtttca ccgtgttagc caggatggtc tcgatctcct 48840 aaccttgtga tccgcccgct tcggcctccc aaagtgttgg gattacaggt gtgagccatc 48900 gcgtctggcc tctaagtctt aattttctta tctgtaatgt agagttgtca ggctagtgca 48960 tgtaataagc actcatgaaa gactgactat tatcttgcga aaaattggaa gagatcatat 49020 gaggtacaag gaccttccat ctgcactggg ctgtacattg aatgttgtgg ttactgttga 49080 agcattggta aatcacatga atccaatggt aaaaccacac cctaaggtca gactcagtgg 49140 ctcacgcctg taattccagc actttgggaa accaaggcaa gaggattgct tgagctcagg 49200 agttcgatac cagtctaggc aacctgtttc tataaaaagt taaaaaatta gcttggtgtg 49260 gtggtgtgca cttctggtcc cagctactca ggaggctaag gtgggaggat cccttgagcc 49320 caggtggtcg aggctgcagt gagccaggat cacaccattg cattccagcc tggatgacag 49380 tgtgaggccc tgtcttaaaa aagacaaaaa caaaccaaaa aaacccacac cctagtgggt 49440 aaggggcagc agaggtccca cccaagagtg aaatcatttt tggtgtcagt aatcagggag 49500 agtaatatac cctcaggcca gaaactagag gtgagtgatg gctcacgcct ataatcccag 49560 caccttggga ggctgaggca ggtggattgc ttgacctcag gaattcgaga ccagcctggg 49620 caacatagga agaccccatc tctaaaaata aatttcaaaa attagttggg catggtggca 49680 tgtacctgta gtcccagcta ctatggaggc tgaggtggga ggatccaatt gagcctgaga 49740 ggtcaaagct gcagtgaatt gtgattgtgc caagaccctg tctctaaaat aaaataaaat 49800 tacaattaaa aactagagct gaaaggacag gttctaggtt aactggtagt agttgttcat 49860 tcatctgtat aaaaagtact tttttgagca cctactctgt gctgtgcatg gaatgaacaa 49920 atgtctttat ttgacttgaa cacagaccat agaagtaact aacagtggaa ctgggagtgg 49980 cactctccat gggacctaaa gacctaggag cctgtgatat gatacctgtc agtgtgaaag 50040 ggctggagtt tgctatctga gccagaccta cactccaaga caggtcttgc tgggatggga 50100 tcaaaattgc tgctgggtca gccgaactat ttttgtactt ctgcttttca cttatattta 50160 tgtcttccct aggtatatag ctgtcttttt ttgtttgctt gtttttctga gtcagagtct 50220 tgctctgtca ctcaggctgg agtgcagtgg cgcgtctcgg ctcactgcaa catccacctc 50280 gggttcaaac gattctcctg cctcagattc ccgagtagct aggattacag gtgcccacca 50340 ccatgcccgg ctaatttttt gtatttttaa tagagatggg gtttagtaga gacagggttc 50400 actgtgttat ccaggatggt ctccatctcc tgacctcgtg atctgcccgc ctcagcttcc 50460 caaagtgctg ggattacagg catgagccac tgcgcccggc cactggagac cccttttcta 50520 ccaaaaaaaa taaaaataaa taaataaata tatatatata tttgtaaaga cggagttctc 50580 tatgttgccc aggctggtct tgaactcctg gcctcaaggg atcctcttgt ctcagcttct 50640 taaaatgatg gggttacagg catgagccac cgtaccaggc cttagcaaac tctttttcaa 50700 gtgctataca aaggggacag aggaacgtga ttgtggccac ctagtatgcc cctattggcc 50760 actgcagtga ggcctaggtg tttgaagaga ggcacctagg gtagtggctc tcaggcacac 50820 cctaggggca ttttggaaat ttgtggggca tctttaatag agacaatgat taggaggcac 50880 tttgagaatt tagtggatgg agcccaggaa aggtagacat tctgcaacat gtagtacatt 50940 catacacaag gaagaattca ctcatttcac ctgacttaca aatataaaat caaatataaa 51000 tcagtaggac tttattataa aatattgcag aaaagtttca caagaatttt ttgtagaaaa 51060 agcccaatca gggccgggca tggtggctca tgcctgtaat ctcaggactt tgggaggccg 51120 aggcgggtga atcacctgag gtcaggagtt tgggacaagc ctggccaaca tggtaaaacc 51180 ccgtcttgac taaaaataca aaaatcagcc aggcatggtg gtgtgcgtct gtaatcccag 51240 gtactcggga ggctgaggca ggagaatcgc ttgaacccag gaggcggggt ttgcagtgag 51300 ccaagatcaa gccactgtgc tccagcctgg gtgaaagagc aagactccgt cgaaagaaag 51360 aaaggaaggg aggaagggag gaagggaggg agggagggag ggagggaaag aaagaaaaaa 51420 gagaagagag gggaggggag ggaagaggag aaaagaagga aggaaggcag gaaggaagga 51480 atccagtcga gatcgttaaa tttgttgtaa ttttgtcttt ggcacaataa acattagtcc 51540 ttattaaaac taactttact tagaaaataa aatagaaaat cctcaaggac aaatcacatt 51600 gtacaggaaa tatgaaatgt gaaataatat ccaccttgga aatttttttt ttttgaaaca 51660 gagtgttact ctgtctccca ggctggagtg cagtggcaca atcttgggtc tctgcaacct 51720 ctgactcctg ggttcaagtg attctcgtac ctcagcttcc caagtagctg ggattacagg 51780 cgtgcaccac cacacccagc taatttttgt attttcattt cagatgggat tttgccatgt 51840 tggccatgaa cacctgtcct caagctatcc actgcctcag cctcccaaag tgctgggatt 51900 ataggcatga gctaccgtgc ccagccaccc tggaaaaatt ttacaaaatg aagtataaaa 51960 agaagaaaag aggggcgggc atggtgcctt gtgcgtgtaa tcctagaact ctgcaaagcc 52020 gaggcaggag atcctttggg tttaggagtt tgagaccaac ctgcacaaca tagcaagacc 52080 ctatttctac aaaaaataca gacactaggc tgggcgtggt ggctcacgtg taatcccagc 52140 actttgggaa gctgaggcca gcagatcacg aggtcaggag atggagacca tcctggctaa 52200 catagtgaaa ccctgtctct actaaaaata caaaaaatta gccgggtgtg gtggcaggcg 52260 cctgtagtcc cagctactca ggaggctgag gcaggagaat ggcgtgaatc cgggaggcgg 52320 agcttgcagt gagccgagat cgtgccactg cactccagcc tgggagacag agcaagactc 52380 cgtctcaaaa aaaaaaaaat tttgctcagt acctggccaa aaaagaagca gctcactccc 52440 tgtacacaga ggggtaagag aaaggagatg gttgaacttc taaactcgct aaagcaggag 52500 aggcaaatgt ggaatgtgct caggaaatat ctgtgagatg aatgaatttg agggaagtaa 52560 ggtactagat aattacctgc cctacccaga acaaatcctg tgcaacgttt ccttgaagag 52620 caggaagtca ggccgggtgc tgtgctcacg cctgtaatcc cagccctttg ggaggccaaa 52680 gtgtgcgaat cacctgaggt caggagattg agaccagtct ggctaacatg gtgaaacccc 52740 atctctacta aaatacaaaa attagccggg cgtggtggtg cgtgcctgta gtcccaacta 52800 cttgggaggc tgaggcagga gaattgcttg aacctgggag gcagaggttg cggtgagctg 52860 agatcggcca ctgcactcca gactgggtga cagagtgaga caacatctca aaaaaacaaa 52920 aaaaaaagag aaaagcagga agtctggaag gggtggctac tgacatagtg aagcaactag 52980 ttcaattcta caacttgaca actacccctg tgccaggctg tctacaagga tatttagaat 53040 gtgtaagaca ttccttcaag gaactccagg aacagaggcc tgacatgttg caatgtttag 53100 tgtcaagcag tgtactagag acacattatc acactcaaac ctcacaacag ttctatgagg 53160 taggagttat cactcccctt ttatagatga aatagaggct tagagtgatt gatttactga 53220 aggtcaaaca gccagtaaat ggtgtagcaa ggattccaac cttgccgtct cactaaaact 53280 gtacaaaaaa agatacaaac aacagacaaa tagttcccag gcgcctccca agttgccagg 53340 cactgcattt acctcactga cccctttgag gttgtggcat tgcctccatt ttctaggtga 53400 ggaaataggc tgagagctgg ggttagtctg gtcatgactg tgtgtgccac tcccaccaaa 53460 tctcatttga tgtggttcat gaggcaaatg gcatggacaa cttccttcac atgtccacta 53520 agcatatggc cttttacaac actttctggt ttctgaacta ctttaaaacc tcactgtcct 53580 gtgaggaagg aagaacagtt attacaatct gcatctggaa gccaattgcc ctttagagat 53640 atggctgcaa ttgcctcact gcctgtgtca tgtgactctc cgaggccctt aatgagtaaa 53700 tgaggggtgc tgcaggggag ccaagctgac cactcccctc cctccagtcc tgccacccca 53760 ctgccagtgt cccaccctcc ttgcgcccta cacttcactg gctaataacc cccctcactt 53820 tttcctgtgt tgaaggcatc ctggataatt ccccacccac gaatggtccc tcctcatctc 53880 agagagctct ccatgcacac ctgttactgt ttctgttttt acctgtaaat atctgtgtct 53940 gacttccatg cttcatgcac ctctataggg caaagactgt gtcttaaaca tcacggtagc 54000 ctcagcatgt tgtgcaatga aggttttttt gtttttgttc tttgtttttt ttttggtatt 54060 agctttattt gtatcatttt gaaattttta tcaaaaaagc agcgtgcctg ctgtggttcc 54120 catcctctgg gatttaggaa tctttacccg attctccatc caagtctgtc tttcgtattc 54180 taggctcttc ctaaagttgt cattcacata taccctccag aattttatag ggtgtataat 54240 ctgtaacaac tcggaggaag ccaattgccc tttagaaata tggctgcaat tgcctcactt 54300 cctgtgtcat gtgactctcc tagtcatcac atgacccatc cacattggga agccagaatt 54360 acttgcagga gtaacctagt gcctatagct atggcaggta tcctgcatcc ttgttttttg 54420 tttagtggat cctctatcct tcagagactc tggaacccct gtgctcttct cctcatctag 54480 tgaccctgag gtgatggagt tttcaagtcc ttccagagag gtaagagaga gagctcccaa 54540 tcagcattgt cacagtgctt ctggaatcct ggcactggaa tttaatgaat gacagactct 54600 ctttgaatcc agggccatca tggctctttg agcaaggcac agatggaggg aggggtcgaa 54660 gttgaaatgg gtgggaagag tggtggggag catcctgatt tggggtgggc agagagttgt 54720 catcagaagg gttgcaggga gagctgcacc caggtgtctg tgggccttgt cctaatgaat 54780 gtgggagacc aggccatggg cacccaaagg cagctaagcc ctgcccggga gagtagttga 54840 ggggtggaga gggacttgct tttcagtcat tcctcattct gtcctcagga atgtcccaag 54900 ccttcgggta gggtaagcat catggctggc agcctcacag gattgcttct acttcaggca 54960 tgtcgtgggc agtcagatga gtgagtcaag gcagtgggga ggtagcacag agcctccctt 55020 ctgcctcata gtcctttggt agccttccag taagctggtg gtagactttt agtaggtgct 55080 caataaatcc ttttgagtga ctgagaccaa ctttggggtg aggatttttg aaaccgtctt 55140 cagtctctcc aaacagctgt gtccgttctc cacatccttg tcagacctca cctctgcttg 55200 tgctccctcc ctcccaggtg gtgcccctgc atccctaaaa gcttcagtac agctcggtgg 55260 tctgtgtctg caatgccaca tactgtgact cttgaccccc cgacctttcc tgccctaggt 55320 gccttcagcc gctacaagag cagaagcagt gggcattgga tggagctgag tacaggacca 55380 tacaggctaa ttgcaccggc acaggtaacc attacaccct tcaccccccg ggccaggctg 55440 ggtcctccta gaggtaaacg gtgtcagtga tcaccatgga gtttctccct gggcactgat 55500 aaccctgtgg atgtcctcag gcctgctact gatcctgcag ccagaagttc cagaaagtga 55560 agggatttgg aggggccgtg acagatgcag gtgccctcaa catccttgcc ctgtcacccc 55620 ctgcccagaa tttgctactt aaatggtact tctctgaaga agatgaggag gaaggggaca 55680 ggatgacata gagccactga cacttttctt tgccaattct tgtggaccct gacttctgcc 55740 catccctgac atttggttcc tgtcttaatg ccagtgaaat aagatttcgc cgcctatcat 55800 ctgctaactg ctacggactc aggctcagaa aggcctgcgc ttcacccagg tgccagcctc 55860 cacaggttcc aacccaggag cccaagttcc ttttggccct gactcagaca ctattaggac 55920 tggcaagtga taagcagagt cccatactct cctattgact cggactacca tatcttgatc 55980 atccttttct gtaggaatcg gatataacat catctgggta cccatggcca gctgtgactt 56040 ctccatccgc acctacacct atgcagacac ccctgatgat ttccagttgc acaacttcag 56100 cctcccagag gaagatacca agctcaaggt aggcattcta gctttttcag gccctgaggg 56160 ccctgatgtc tgggggttga gaaactgtag ggtaggtctg cttgtacaga cattttgtcc 56220 cctgctgttt tgtcctgggg gtgggagggt gggggctaat ggctgaaccg gatgcactgg 56280 ttgggctagt atgtgttcca actctgggtg cttctctctt cactaccttt gtctctagat 56340 acccctgatt caccgagccc tgcagttggc ccagcgtccc gtttcactcc ttgccagccc 56400 ctggacatca cccacttggc tcaagaccaa gggagcgggg aatgggaagg ggccactcaa 56460 gggacagccc agagacatct accaccagac ctgggccaga tacattgtga agtaagggat 56520 cagcaaggat gtgggatcag gactggcctc ccctttggcc atgctgatct gtgtcccaac 56580 cctcaacctg gttccacttc cagatctgcc tgtcctcagc tcacctttct accttctggg 56640 cctttcaaac ttggatctgt cagtcttgcc cactccatca ggcttcctgt tctctcggtc 56700 tggcccactt tcttggctgg atcactcatg acctttctct tgccaggttc ctggatgcct 56760 atgctgagca caagttacag ttctgggcag tgacagctga aaatgagcct tctgctgggc 56820 tgttgagtgg ataccccttc cagtgcctgg gcttcacccc tgaacatcag cgagacttca 56880 ttgcccgtga cctaggtcct acccttgcca acggtactca ccacaatgtc cgcctactca 56940 tgctggatga ccaacgcttg ctgctgcccc actgggcaaa ggtggtaagg cctggacctc 57000 catggtgctc cagtgacctt caaatccagc atccaaatga ttggctccca aacttagagg 57060 gatttttcta cccaactatg gatcctagag caccattccc cgggacctcc agggtgccat 57120 ggatcccaca gttgggactt gaaacctctc taggctgggg gtggtagctc atggctataa 57180 ttccagcact ttgggaaccc aaggtgggtg gatcacttga acctaaggag ttcaagatga 57240 gcctgggaaa catggtgaaa ccctaactct acaaaaaaaa aaatagaaaa gttagccggg 57300 tgtggtggtg gcacgcctat agtcccaagt attctggagg ctaaggcggg aggtttagtt 57360 gagcctagaa tttcaggctg cagtgagcta tgattgtgcc actgtactcc agcctgtgtg 57420 acagagggag accctgtctc aaaaacaaaa acaaaaaatc cctcccaaaa cctctgtagt 57480 tgcattcttc ccaccaccta attcaggatt cctacaagag gaactagaag ttccagaagc 57540 ctgtgggcag ggtccagggt gacttgttct tcctttgcag gtactgacag acccagaagc 57600 agctaagtat gttcatggta ttgctgtaca ttggtacctg gactttctgg ctccagccaa 57660 agccacccta agggagacac accacctgtt ccccaacacc atgctctttg cctcagaggc 57720 ctgtgtgggt tccaagttct gggagcagag tgtgcggcta ggctcctggg atcgagggat 57780 gcagtacagc cacagcatca tcacagtaag ccaccccagt ctcccttcct gcaaaggagg 57840 acctcagacc cattagtagt ctcaccaaag actgatagaa gcccttcctg tccagctttc 57900 cccaggtagc ctgccctttt gggcaactct ggggaaccat gattccctgt cttgcctttc 57960 cttcacaggt ctgcacacct cattgcccct tttgcaacta ctgaggcact tgcagctgcc 58020 tcagacttct cagctcccct tgagatgcct ggatcttcac acccccaact ccttagctac 58080 taaggaatgt gccctcacag ggctgaccta cccacagctg cctctcccac acgtgaccct 58140 tacctacact ctctggggac ccccagtgtt gcgcctttgt ctctttgcct ttgtccttac 58200 cctagaacct cctgtaccat gtggtcggct ggaccgactg gaacccatca ttgtagacat 58260 caccaagcac acgttttaca aacagcccat gttctaccac cttggccact tcaggtgagt 58320 ggagggcggg gcacccccat tccataccag gcctatcatc tcctacatcg gatggcttac 58380 atcactctac accacgaggg agcaggaagg tgttcagggt ggaacctcgg aagaggcaca 58440 cccatcccct tttgcaccat ggaggcagga agtgactagg tagcaacaga aaaccccaat 58500 gcctgaggct ggactgcgat gcagaaaagc agggtcagtg cccagcagca tggctccagg 58560 cctagagagc cagggcagag cctttgcagg agttatgggg tgggtccgtg ggtgggcgac 58620 ttcttagatg agggtttcat gggaggtacc ccgagggact ctgaccatct gttcccacat 58680 tcagcaagtt cattcctgag ggctcccaga gagtggggct ggttgccagt cagaagaacg 58740 acccggacgc agtggcactg atgcatcccg atggctctcc tgttgtggtc gtcctaaacc 58800 ggtgagggca atggtgaggt ctgggaagtg ggctgaagac agcgttgggg gccttggcag 58860 gatcacactc tcagcttctc ctccctgctc cctagctcct ctaaggatgt gcctcttacc 58920 atcaaggatc ctgctgtggg cttcctggag acaatctcac ctggctactc cattcacacc 58980 tacctgtggc gtcgccagtg atggagcaga tactcaagga ggcactgggc tcagcctggg 59040 cattaaaggg acagagtcag ctcacacgct gtctgtgact aaagagggca caacagggcc 59100 agcgtgagct tacagcgacg taagcccagg ggcaatggtt tgggtgactc actttcccct 59160 ctaggtggtg ccaggggctg gaggccccta gaaaaagatc agtaagcccc agtgtccccc 59220 cagcccccat gcttatgtga acatgcgctg tgtgctgctt gctttggaaa ctgggcctgg 59280 gtccaggcct agggtgagct cactgtccgt acaaacacaa gatcagggct gagggtaagg 59340 aaaagaagag actaggaaag ctgggcccaa aactggagac tgtttgtctt tcctggagat 59400 gcagaactgg gcccgtggag cagcagtgtc agcatcaggg cggaagcctt aaagcagcag 59460 cgggtgtgcc caggcaccca gatgattcct atggcaccag ccaggaaaaa tggcagctct 59520 taaaggagaa aatgtttgag cccagtcagt gtgagtggct ttattctggg tggcagcacc 59580 ccgtgtccgg ctgtaccaac aacgaggagg cacgggggcc tctggaatgc atgagagtag 59640 aaaaaccagt cttgggagcg tgaggacaaa tcattcctct tcatcctcct cagccatgcc 59700 cagggtccgg gtgcctgggg cccgagcagg cgttgcccgc tggatggaga caatgccgct 59760 gagcaaggcg tagcccacca tggctgccag tcctgccagc acagatagga tctggttccg 59820 gcgccggtat ggctcctcct cagtctctgg gcctgctggt gtctggcgtt gcggtggtac 59880 ctcagctgag ggtcaaggaa ggaaggtgtg ttaggagaac tagttcttgg atccctgccc 59940 actctcccca gggctgcccc tcccatctgc cccttacctc catcccaggg gaagtagaga 60000 ctgagaatgt gggtacaata ggcacagagg ttgtgcagcc cacgcaggtg gacctgcagc 60060 ttcccactgg gcagctttgc ctgcagcagc agggccaagt agctgaagac gaaggcgtcc 60120 aaggaggcag ggctggagca gagagagaag ggtgggatgg aggagaacca ctggggtaga 60180 aggggtaaag atggagctgg aggaagagtc agccttggga ggtgggctct gggcagcagg 60240 cggccaccag ggaaggacag gacacacagt tctagacctg gtatggggag agatccccag 60300 gtggcgccag ctggccctga atagggctct atcccagggc tgcataaagg gcacattcag 60360 tgccccacag ctcttcaggc ccctcctgtg cctggctgcc ctcccaccct acccttttgt 60420 acctctgaga aggctctggc ccccacacag tcacactgtc actagggcca gtttctatcc 60480 cagggacctc ctatccagag cctgagccag ccccagcccc agccccagct ccagctgctc 60540 catctgaacc tgtatcttct tccaagccac ccattaccct cttggagtca gactcacgca 60600 tctccaaaga agaacttttg agagcccagg cgctgagaga gcagggtcag acactcccga 60660 gcctctcggt acagctgtag gggcgacaca ggtaggcttg cagctgtggg aacagtgcca 60720 cctccccacc taagcactcc cattcctggc cagcatcctt ggggctcatc tcatacaata 60780 gcccccggtc tcagagctac ctccttctcc agctcttcct cgtcctcagg cctgtgctcc 60840 ccagtcagca gctgtagccg ttccatgtac tgccgctgca tgcggccagg caggaagaag 60900 ttgaggggaa agggcatagc ctctgcatac cacttccggg tcacttccac gtagttcttg 60960 gtgtctatcc aaaaagtatg tacctggatt gggtgggcag gaagaaacag gtaggtctga 61020 gccagtgcac ctgtctgatt caaggtgggc ttctgacccc catgctttcc tgagcctgtg 61080 tgtgggtctg tgtgttcccg aaccctcccc ggctggccat ggatgctggg aggtctgggc 61140 acactcacca gcaccgggag caacttctcc tccaggagag acatgaaggc cagggtgtct 61200 gccccttgcc gagctgacag atcataatca gcattgtact tctgtggagg aaatatccat 61260 ggcgtggaca ctagggagct gcaagggcac ttcaccaggg aggaaggagt cctgtctggt 61320 acccccctca ctggcctctg agtgcagtgg aggtacagca aggaactttt cctgccaagg 61380 cccccttgcc tgggcccagc cagtagcctg ttgctgttgg cgaaaagcct gggccttgga 61440 gcctcctggc cgtgaaggtc cagcgcccaa tgcagggaag gaaggaaggc tccgccgcaa 61500 actaggagca gctcccagaa tttccatgga aagctggaac aacgcccgct gacggcaact 61560 ttctaacagt aacttccccg acccagacac cacaaagcta gcacaacgga gctcagatgc 61620 aggctaggac tcggtccatg cctcaggaac cagagaaagc catcctcaca ctccctggat 61680 ccagggaacc cacgcccagg gccccccagc ttgttccctc agtgcccagc tcttggctat 61740 ttctttcact tcattccatc gctcagacac cattaccaca tacacattcc acccataccc 61800 ccaggtctca gcctgcccta ccttcccagg ctccagtccc tgttcctcag catccccctc 61860 cacatcctga gtaagctttg tccccagata acctcttcag catgatcctt aaatctccct 61920 aagcctcagt ttctcccctg tggaatgggg gtaagaatct ctttctctga atgcccctgt 61980 gttaggaaat aatttagaat actttggaaa ctggaaaagc tctgttcaca cctaagcaat 62040 cagggcagtg gcctcggctc tgccaggaac tttggctttt atctggatcc tctctttcca 62100 ggcctctcaa ttaattcccc aggtcctcaa cctttgggaa gttagaaatg aggaagagtg 62160 tcctacttct gacactgttc cctcttggaa cctgaccgtc aatgctagaa gaacccttgg 62220 aaaacatgct ggcccagccc tctagtttta caaataaggg agtgcacagc cctgagaggt 62280 tacatggcct gcccgagatc acatagtcaa tggcagagta aagagcatag cctaggcctc 62340 cccactcctc tagtaatgct ctttcatctt ctccaacctg gctctaagcc ttgtccatcc 62400 tgagccccat atctagccca acctagtccc tgaaaacagg aagtggccct tagaaatctc 62460 tctccagtcc caccatcaga ggccaactgc tgtcttccac tctccttcag cctgtgctcc 62520 tctccctccc tgcctcacag tgccctaagt ttcatctctt gccgactgct ttaatacatc 62580 acagtgacat tgtgtgtgtc tctgccacaa gactgttgct ccttgatgct ctgggtcacc 62640 tgcatctagc atggcatata tctggtgctc aataaatgtg tattgtatag aattgactga 62700 acttctctca ctggcagccc cctctatcca agtcacctac ctcttttcga aggtgggtga 62760 tgatcttgtg tggaactgag atgacctctc catgactggt ccgaagggca ggcagagttc 62820 ctgatattga gagggaagta taccaaccag acccttagct gcctagtcat acatagttgc 62880 aacacattcc tgcctatttc ttgcttctcc ccttgtacac acccttcctt acccccaagg 62940 gatactgggt acctgaaggg ctctgccagg ggttgctgat cttgtgtacc ttcagtggag 63000 caccagtaaa tctggcatag gtctgcaggg aaggaagcag aagtcagaga ggcagagcca 63060 tgtcccccac agtggtatca agaagagaaa taacatttat tgaatacctt atgtgccatt 63120 ccctatactt agtatcttag tctcgaaaaa aaagggggag tcactaccat ttctatttta 63180 caaatggaca acacagggct cagagagatt ccggacatgt ctgtgattac aggacagcca 63240 ggaaaatcct ttcctctatc tcctctcttg ccatctacct ggtgaacatc tatcctcaga 63300 agcttttcct aaccagtatc cctcttcttg gaagcactga taatgccctt ctctttggca 63360 gtatctgtgg tctgttccta ctttaactta tatgtgaata ttttattata tttatttgct 63420 tacctatctg cctttctgta aactcgaagg gaggaaccaa attttattca tctttgcctg 63480 gcaatgttta atatttggaa gaaatctaat agatcctctt taaagcaagg agtcaatgaa 63540 taaatgaagc aaaggaagtc tgattgctaa gctctttata caaagcctgg ctgtgagtcg 63600 tttggtctaa caaacaatag cctcagtaaa tgctgttaag tgaggaggaa gaggagaagg 63660 gggctgagga gaaggcagga attccaagct agagtaggtc cctgagacag tccagcctag 63720 taaacctccg aatggagaaa aaaaatgccc aaagagaaag gatctccgca aggtcacaca 63780 gccagtgaat ggatgagcaa ggactagaac ccatcacctg aactcccaac caggcgtctt 63840 ttcattgctg cattaagcct agaaaactac agcatagggc actgaggcca tatcggccac 63900 gtacgctctt tgactgcctc agtttccccc actgcgcccg tgctgagtag ccctggcaag 63960 gtttggatgc ttggctagtt cggccccctc cccagtcatc agggcacagc agagggcgcc 64020 ggcgccaccc ctcaccagca cggccaggct gtccaggtcc actgacggca gcccccagcc 64080 ccctgaccag cagaacagct ccatgggcgc cgccatcttg cccaccctct gtcccggaaa 64140 cacttccttg tgtgcttctg ccctcccctg cctgggcccg ccccccgcca ccgcccctcc 64200 gatcgttgcg gtcagggggc ctggggagat ccccggggag gcgaggcttc ttctggcccg 64260 actggcagct gaactgcggg ggactgggcc gcgggcctcg ggggagggcg gccgccggcc 64320 catccagagg tggcccacgt agcgggacag cgctgtcggc ccggcgcgcc tcggagtgtc 64380 acggcgcctc gtccaagtgg agccccgaac ccctgaaggc gcggcaggct ctggagagcg 64440 gggtcttgtg cgcctgggcc aggtctgggg gctcttgcca aactgcacgt ggcctgtact 64500 gctccagggc cccttggggc tcgtccccga gcggggactg cgggggggtc ccccgagcag 64560 catgttttcc acagcgcgtt atgtttggag cgggccctgc gccgcctgtc gccatggaaa 64620 caaaacaggg gcggtggcgg cggccggagc ggaggccggg ctggggcttg ggtgggggag 64680 gggaagagag gctcgcaggc tgtcgcttag gtgacgggaa ctcaggcgcc cctctgcttc 64740 atccgggtca cggcccgtcc gctagtaccc acagtgttcc acagtctggt ccttggctcc 64800 tcgcctgtac ccctggtctt ctgcgcctgt ccctggtgtc cctttcctct tttttggttt 64860 cttcactctg acctcactga ccactgcttt agattctccc ttcagttccc gtcagacgct 64920 tccagactcc caagctttcc tacgaatgag ggaaaatgga gaaacaggca cttgtcaggg 64980 gacccccacc ctaataaaga gcacttgctc cgccagaaca gcaaaattca tgccatgtgg 65040 gcatccctgg gcactatagc aagctagttg cggccactcc cttggcatcc tttcctgcca 65100 gctgtggaat aatgcccact gtctagcact gcccctgcca ggggttcttg ccttccacaa 65160 tcgtggcttc cagaaaacag tggcattcgg tagcgctgtg tgccgagacc cccaacaatg 65220 atgactgcgg agagggaggc acctgggggg aggatcatta gggagaggta gaaagcaggg 65280 aggcctccag gattctttcc cagtgcccct ggttcccaga gctgatgatg cctccagggt 65340 gattggcagc tctttgtttc agccccccct cacccgcctg ctggcccccc ctccaattct 65400 gtccctccgc cccccggctc ctgctctctc cgcctagcct tttcccctcc cagctgcctg 65460 cctgccaggg gtagtgagcc ggctgagagg catggagacg caggaacttc ggggggccct 65520 ggctcttctc ctcctttgct ttttcacatc tgccagtcag gatctgcagg gtaagcctgt 65580 ctccatcctc ttagaccgct ctctgcttct tccccatttg ccctcagccc aagtagcaga 65640 gaacatgtgg gcaaggggag aggggaagag tccagaaatt gagccagagg aaaacttaag 65700 actgcctaga gttggtgaaa ttatggcctg gtggagagga gtgggcaccg gagagtagtg 65760 ggggagctgg aacaggacag ggtcaggcat gaggccaggg cagaggactc aggaactgga 65820 tgctcaggct gcctggctgg ggtggttcct gagcatctgt aggcacccta gggtctggga 65880 gagcagcctg aaggtgggcg tactgtaggt ccctgggctt cgtccccctg ggctcctggc 65940 tgcccaagga cagggcgggg gtggggacca agaagcctgg gctctcccgg aggtctggtg 66000 gtgggatggg ccgatggatg tgggagaggt agctggagca gatgacacag gcatagattc 66060 tttactggct ggagggaaaa ccacagattg gccaggacac aggaggcaga ggagctgggt 66120 cctacattcc cgtgggagat agcccagatg gtgggagggt tagagtcctc agtgggcagc 66180 tgttcttatc cagagcgagt gtgctgcgcc cctaggatgg gaggagggga actagggtgt 66240 ggaacgagcc aaacccagga gtggaaagag aagctgcctt ccatttctac gttgtggaca 66300 ccaggtgcca ctcctgtggg ggatcagcac agcatctcct ttgcgccacc tggtgggggc 66360 atctcaaatt tgtggggtgc tgtttctgtg tttccaagtg agtctcaaac ctgcaggttc 66420 ctggaaggta gtaataggca ataatgggga aaggaaggca cagtgcctct gtcctctgag 66480 agcaacaagg gttgaggttt ttttttgttt tcgttttgtc tttttgagat ggagtttcac 66540 tcttgttgcc caggctggag tgcaatggcg cgatctcggc tcactgcaac ctccacctct 66600 caggttcaag cgagtctcct gcctcagcct cctgagtagc tgggattaca ggtgcccgcc 66660 accacgcccg gctaggtggt ttttttttct tttttgttgt tgtttttgta tttttagtag 66720 acacggggtt tcaccgtgtt ggccaggctg gtctcgaact cctgacctta ggcgatccac 66780 ctgcctcaac ctcccaaggt gttgggatta caggtgcgag ccaccatgcc cagccaaggg 66840 ttgaattttg aggtgactaa cgctgcctgg tggtgggggt agggggtgat gtgggctcgg 66900 ggagggcata ccttagcatt tgatcccatt ctctaacctt gataacccct gcctgaccag 66960 taattgacct gctgactgtg ggcgagtctc ggcagatggt agctgtggca gagaagatcc 67020 ggacagcctt gctcactgct ggggacatct acctcttatc caccttccgc ctgcccccca 67080 agcagggtgg tgtcctcttt ggcctctatt ctcgccaaga caacactcga tggctggagg 67140 cctctgttgt aggcaagatc aacaaaggtg actggtgggc atctcctttc ttgcaatggt 67200 gacctcctta agcactctcc ctcatcccta cttcccaagt gcttcctcat tctccttggc 67260 ctccattagg gaccaaggtc ccatcaggct gtgcccagac atcaggggca cctggtatgg 67320 ggtgcttata aggtgcttta ggagcccatg taccaaacaa tagggtgagg cttgagtcct 67380 gatatttata gggatgggag gttgtacttg gggatgcctg gaaggagggt gaggcatgtc 67440 tctgtgcctc agcggtgata cagaaaggtc tttcagatcc ctggaacagt cagtggccac 67500 aaaaccagct gtcaccctag gagaggatac agtcatctga taccaatgaa gactaagaaa 67560 gtatttgtct ctaaaccaat tattttttta aatggagtct tgctttgtca cctaggctgg 67620 agtgcagtgg tacaatctca gctcactgca acctctgcct cctgggttca agcaattctc 67680 ctatctcagc ctcctgagta gctgggacta caggtgccca ccaccatgcc tggctaactt 67740 ttgtattttt agtagaaaca gggttttgcc atgttgacca ggctgttctc gaacttctga 67800 cctcaagtga tctgcccacc ttggccttct aaagtgctgg gattacaggt gtgagccacc 67860 gtgcctggcc tctaaagcaa tttcaaaaac atttattgtg tacctattaa atacaaggtg 67920 ttgagagcca catagtagaa ttagggatag gggccctaga gatgtggtat ctagcagagt 67980 tgatccaagg ctcagctggg aggcaggggg tgggggatag cgcccatact gatctcccct 68040 cctgggcagt actggtgcga taccagcggg aggatggcaa agtccacgcc gtgaacctac 68100 agcaagcggg cctggctgat gggcgcacac acacagttct cctgcgactc cgaggtccct 68160 ccagacccag ccctgcccta catctctacg tggactgcaa actgggtgac caacatgcag 68220 gccttccagc actggccccc attcctccag cggaggtcga tgggctggag attaggactg 68280 gacagaaggc gtatttgagg atgcaggtga gccgggagga gcctctgagt tctgtggaaa 68340 tagagtttgc accagctggg gaaggggttg gtagaccttc ccaccttact ctgctgctat 68400 ccccccaggg ctttgtggaa tctatgaaaa ttattctggg tgggtccatg gcccgggtag 68460 gagccctgag tgagtgtcca ttccaagggg acgagtccat ccacagtgca ggtaacacag 68520 agacttgttt gctgacattg gaccacggat cctgtggcct ttggtgactc ctgtcttctt 68580 gatctccctc tcccttaaaa cccattcctt tggctcacct gttcctaggg tttctaaccc 68640 tgttattcca aatctttcac ctgactccac aatctccaat acacccatcc gagaaaaaaa 68700 gtgatctaag agaagaattg gttaattgct tggccttggc tgaccaagag atactggtct 68760 cgagtatttt tttttttttt ggtgatggag tcttgtcctg ttgcccaggc cggagtgcag 68820 tggtgcaatc tgggtcactg cagtctccac tgagttcaag tgattctcct gcctcagcct 68880 cccaagcagc tgggattaca ggcggccctc caccatgcct agctaatttt gcatttttag 68940 tagagatggg atttcaccac gttggccagg ctggtctcaa acacctaatc tcaagtgatg 69000 cacccacctc ggcctctcaa agtgctggga ttacaggcgt aagccaccgc gcccggcctg 69060 gtctcgagtc ttttatagtt ctcactggca gctgtcacca gcaatttctc tgagtgttgc 69120 ccatctgcct ggtctctctg acagggatgt tcagaagctc tcacctaaat aaaagaccca 69180 cctttcccag atatttgagg gagagctctt gaagaaggga atgggatggc gggtgtggtg 69240 gctcacacct gtaatcccag cactttggga ggctgaggtg ggctgatccc tcaaggtccg 69300 gagttcaaga ccagcctggc caacactgtg aaacctcctc tctactaaaa aatacaaaaa 69360 attagctggg catggtggtg ggcacctgta gtcccagcta cttgggaggc ggaggcagga 69420 gagttgcttg aacccaggag gtggaggttg tggtgagcag agatcacgcc actgcattcc 69480 agcctgggaa acagagcaag actccgactc aaaaaaaaaa aaaatgggga tatactgggg 69540 ccctggccct gctttgggtc catcccttct gccactacca tgcctaggaa ccaggaggat 69600 ttgggttcta acttcctgtg aagcaactcc cttagagggc cttttgcccc atagaaggag 69660 ctggcactgc ttgtctgcca gctctgccct cccagcatcc agcaccccat ctttattctg 69720 gggctccagc cctgtccctg tcctcacctt ccttcctcct tctcaccaac caggcctctc 69780 ttcacttcac ctcacccctc tgactatgtt ttcttctcct ctccagtgac caatgcactg 69840 cactccattc taggtgagta ggccacactg aagcggaagc ggggagcggg gaggaggccc 69900 caggctctgg cagctgcctg aaactaagtc ctcttcagtc aggaatgtag taggtttaaa 69960 ggcaggggtg ggcagccgtg gcaggtactg gcttattgcc catggagggc ccaggactgg 70020 tgctccagta ctgaacccct cacaccctgg gtcccgacag gggagcagac caaggcgctg 70080 gtcacccaac tcaccctctt caaccagatc ctggtggagc tgcgggatga tatacgagac 70140 caggtttggg tgggctggcg aagggtggca ctgattctgg ggtagggtgg cagatgtcaa 70200 gtgctgactc ctccccatcc ttctccaggt gaaggaaatg tccctgatcc gaaacaccat 70260 tatggagtgt caggtgtgcg gtgagtggga gagcagggga ggctccacat gaccgtgcca 70320 cgttcccacc attggctttg gctttccctt ctggtggctt aaatagtgac caccgggtag 70380 ctctgactgt gtccacccct caggcttcca tgagcagcgt tcccactgca gccccaatcc 70440 ctgcttccga ggtgtggact gcatggaagt gtacgagtac ccaggctacc gctgtgggcc 70500 ctgcccccct ggcctgcagg gcaacggcac ccactgcagt gacatcaatg aggtgaggga 70560 ggtcagagcc cagaagggta cagaaaactg gggtgaggat gtcaggaggc acccaagagg 70620 gtgggataaa tgctggtccg gaggagagga atctggagtt taggagaggt cagaggcaag 70680 agaaatgcaa gatgggagag acagaaggcc tggggcaaag actgaaggcc atacagggaa 70740 ggagctgggg aaactgcagg ggaggcttga gatggcgacc agtggcatgg ggagggagag 70800 agggaacccc gagggaagtg gggtggggac caggagcaca aggcagttgt gtggggagag 70860 ctgcacaaag gggagacctg gagcaatggt tcctggatca caggcaggga cctgagtttc 70920 ccagagggcg gcctgacctc tgccttctca tctggtcccc agtgtgctca cgctgacccc 70980 tgtttcccgg gctccagctg catcaacacc atgcccggct tccactgtga ggcctgtcct 71040 cgagggtaca agggcacaca ggtgtctggt gtgggcattg actatgcccg ggccagcaaa 71100 caggtcagac tgggtagtgt gtgtggacaa gggatcttgg ccttgtagag gccaggggct 71160 tctgggttgg acatgggacc cttgtgatga atgggacatg gatggctttg catcggcttt 71220 gggtctgggc ttaatgttga tgttcacaga taaggccata ccagtgtcct ctgctgtatc 71280 tgaggagacc caccataggt ctggttccac ccaaagtctg ccccttcagg tctgcaatga 71340 catcgatgaa tgcaacgatg gcaacaatgg tggctgtgac ccaaactcca tctgcaccaa 71400 cactgtggtg agctgaatat cctgagtgta ttctggggtg gtgggaatgg taaaacccca 71460 acccccgccc cttcttacct tcaaatttcc tgctgccttt cctcctcccc agggcactac 71520 acagattagg tgttcacatg gacttggttt ggaatactgg tttgcctctt gctagctctt 71580 tagcaggtta tttaactttt ctgagcctca gcttcctcat ctgaaaactg aggctgttat 71640 ccaccctgaa aggttgtcat gataacctaa aggagatact gatatgcctg gcataactga 71700 gtgcccagcc cacactccgc aggtggagca gtgctggtcc tgggtgcctg gtgggctcac 71760 cctccttcct aagatgctgc ctctccactc ttagggctct ttcaagtgtg gtccctgccg 71820 cctgggtttc ctgggcaacc agagccaggg ctgcctccca gcccggacct gccacagccc 71880 agcccacagc ccctgccaca tccatgctca ctgtctcttt gaacgcaatg gtgcagtgtc 71940 ctgccaggtg agctaggctt caggcgtgga aggaaaaggg agggtctggg gaaaggagta 72000 gggctatgtt tagggcctgg gttgggggtc ttcataggag agaaggtggg cctgggccca 72060 ggaactgttt ggtggggaga ataggacctg aagcagggaa aatataggga ggaggggagc 72120 cagaccaaac tgctagctcc taccctttgt gttgccctag tgtaacgtgg gctgggctgg 72180 gaatgggaac gtgtgtggga ctgacacaga catcgatggc tacccagacc aagcactgcc 72240 ctgcatggac aacaacaaac actgcaaaca ggtgcaggga gcaggcgggc aagggggcgt 72300 agtggggagc ccaagctggg tcaggccaga actcatccat cctcttcccc tgaactttag 72360 gacaactgcc ttttgacacc caactctggg caggaagatg ctgataatga tggtgtgggg 72420 gaccagtgtg atgatgatgc tgatggggat gggatcaaga atgttgaggt gactcccaga 72480 ctgccctgcc ccttgaagct cctctcccct cctcctgtcc tctctgtgcc tcacttacct 72540 catctggcag ctctctagta agggccaaat actccaaatc agggaggcaa aaacctcgtg 72600 cccaggacaa ggaggctggg tgggtgggac tgtactgagc agtttgtcca tcacaagggt 72660 gtgatcttag aaaaggatac agagacaagg taggtgcaag atgacaagtg atttagggga 72720 gacctgaccc ttcccctccc accctctgcc caggacaact gccggctgtt ccccaacaaa 72780 gaccagcaga actcagatac agattcattt ggtgatgcct gtgacaattg ccccaacgtt 72840 cccaacaatg accagaagga cacagatggc aatggggaag gagatgcctg tgacaacgac 72900 gtggatgggg atggtgcagg cctggggctg aaggggtggc tgggggacct gtgagaattt 72960 ggatcaggtg gggatgaagc agggaagcta ggaagtctct gtgaaatagg gaggcaggct 73020 tgtggacgtt ggcctgggtg aggagagatt acctgcagca gatgtcaata ggaatgtgag 73080 gtagggcgta gtgttaggca gagtgtggac tagagggtga gacaagaaac aggcagattt 73140 cctggccagt tgtcctctgg gtggggagac aaagttcggg actttcacca acctagaaga 73200 gagaatatgg catgttctag taacaacctt gtgctaccca tgtcttctag gcatccccaa 73260 tggattggac aattgcccta aagtccccaa cccactacag acagacaggg atgaggacgg 73320 ggtgggagat gcttgcgaca gctgccctga aatgagcaat cctacccagg tacagggaga 73380 tggtaaggac aggggaggga tgagggtact gatggatgaa gccccagccc tttggatgga 73440 aagtggtcag atcaccctct tcagagttat caagaggaga tggtgagaac aggtccctct 73500 ctctcagaca gatgcagaca gcgacctggt gggggatgtc tgtgatacta atgaagacag 73560 gtaaggtctt ggtcaagaga cgcaaggtct ttcttttttt tgtctttctg agacggcttg 73620 ctctgtcacc taggctggag tacagtggca cgatcttggc tcactgcaac ctccgtctcc 73680 cagggtcaag tgattctcat gcctcaacct ccctgagtgg ctaggattac aggcatgtgc 73740 taccaagccc agctaattct tgtattttca gtagagacag ggtttcacca tgttggccag 73800 gctggtctcg aactccttac ctcaggtgat ccgccagcct ctgcctccca aagtgctgtg 73860 attacaggtg tgagccactg tgccagcgaa atgcaaggtc ttatagggga tattttactt 73920 tcctctagta tatccttttt tttttttttt tgagacggag tcttgctctg tcgcccaggc 73980 tggagtacag tggcatgatc tcggctcact gcaagctcca cctcccgagt tcacgccatt 74040 cttctgcctc agcctcccaa gtagctggga ctacaggcgc ctgccaccac gcccggctaa 74100 ttttttgtgt ttttagtaga gacggggttt cactgtgtta accaggatgg tctcgatctc 74160 ctgatctcgt gatttgcctg cctcagcctc ccaaagtgct gggattacag gcgtgagcca 74220 ccgtgcccgg cctccttttt ttttttgaga tggagtcttg ctctgtcact caagctggag 74280 tgcagtgata tcggctcact gcgacctcca cctccagggt tcaagcgatt ttcctgcctc 74340 agcctcccag tagctggatt acaggcgcgt gctaccaagc tcagctaatt tttgtgtttt 74400 tagtagagac agggtttcat cgtgttggcc aggctggtct cgaactcctg acctcaggtg 74460 atctgcccgc cttggcctcc caaagtactg ggaatacagg catgagccac tgtgcccagg 74520 ccatagtata ttctaaattc cttctatgat ttagccttaa ttctctattg ctattcagca 74580 ggaatttatt cttacagtca tccctccatt cctactgcca gaccttcacc tcacctggct 74640 gactgccagg ggtctgattg tatggagagc aggctccaga gactcccagg cagaagcgaa 74700 gggaaggaca aggagtacct ttaaatcctt tatttggtac ctgttcttct gattagcgat 74760 ggggatgggc atcaggacac caaggacaac tgcccacagc tgccaaatag ctcccagctg 74820 gactctgata acgatggact tggagatgag tgtgatgggg atgatgacaa tgatggcatc 74880 ccagattatg tgcctcctgg tcccgataac tgccgcctgg tacccaatcc caatcagaag 74940 gactcagatg gtaagcctgc ggacccagag cacgttagac tggtgttgcc tttgcccagg 75000 tggaggcagc aagccctgtt gggaagtgag gaagggcaag gtgggaaaga tgtcaggaat 75060 gcaggcccaa cagatggtat tgttgcctaa tggcagtggc cagggccttc ctgagcaccc 75120 agcctcactc tgcccaggca atggcgttgg tgatgtgtgt gaggatgact ttgacaatga 75180 tgctgtggtc gaccccctgg atgtgtgtcc tgaaagtgca gaggtaacgc ttacggattt 75240 tcgggcctat cagaccgtcg tcctggatcc 75270 <210> 55 <211> 2385 <212> DNA <213> Homo sapiens <220> <223> Genbank Accession No. X86809 <400> 55 gccagagcgc gcggggcagt gtgcgcggga gccgaggagg aggttccgga cgctgcttag 60 gaaccgggga ctcaggagtg cccgcgccct gagcgctcag ctccagaggc gtcatggttg 120 agtacgggac cctctttcaa gacctgacca acaacatcac ccttgaagat ctagaacagc 180 tcaagtcggc ctgcaaggaa gacatcccca gcgaaaagag tgaggagatc actactggca 240 gtgcctggtt tagcttcctg gagagccaca acaagctgga caaagacaac ctctccatca 300 ttgagcacat ctttgagatc tcccgccgtc ctgacctact cactatggtg gttgactaca 360 gaacccgtgt gctgaagatc tctgaggagg atgagctgga caccaagcta acccgtatcc 420 ccagtgccaa gaagtacaaa gacattatcc ggcagccctc tgaggaagag atcatcaaat 480 tgggtccccc accgaagaag gcctgagcaa gggggaggaa gaggaggaag gttggacctt 540 catcagacca cttccttccc ccatcctcca ggagaggggg caagggcaac ccaccatcta 600 cccacttact aacctggtcc taaccccctt actgtgcgcg tgtgtgtgcg tgtgcgcagc 660 tctggctgtt tgtctatatg tctagctcat ctagttcctc ttcttaaggg gatgggggtc 720 aggggctagg ggagggggct gagtttcccc actttaggag gaggtggggg ctatttctat 780 gcaaatagaa atcagcacat tcctcctact tccctttcct ccactccccc catatcttta 840 aagtgtggaa gcagaaagga cctgcatttt cctacattga ggagctgaca taggggtaag 900 gtatgggaga ggtaggtgga tccagggaaa agcagtgggg acggaaggca aagagaccac 960 ttaaccccca cctggaaggg gcaaagaaaa gccagagttc catgtttgta ctcctgtgct 1020 ggactgtttc ctgagtacca gcaggtccct ttttgtctct catgggccta gcataggtat 1080 gagccaggga tcctttcctg gtccctaaga tcaaacccca tggagcagcc agcgttagat 1140 gcccccaccc acctgtactc tggagagact gtgctgggaa catgtaccac tgagcctgag 1200 atggggatga gggcagagag aggggagccc cctcttccac tcagttgttc ctactcagac 1260 tgttgcactc taaaccttag ggaggttgaa agaattgaga cccttaggtt ttaacaacga 1320 atcctgacaa caccatctat tagggtccca aattggttat tgtaggcaac cttccctctt 1380 ttcttggtga agaacatccc aagccagaaa gaagttaact acagtgtttt cctttgcacc 1440 gatccccacc ccaattcaat cccggaaggg acttacttag gaaacccttc tttactagat 1500 atcctggccc cctgggcttg tgaacacctc ctagccacat cactacagta cagtgagtga 1560 ccccagcctc ctgcctaccc caagatgccc ctccccaccc tgaccgtgct aactgtgtgt 1620 acatatatat tctacatata tgtatattaa aactgcactg ccatgtctgc ccttttttgt 1680 ggtgtctagc attaacttat tgtctaggcc agagcggggg tgggagggga atgccacagt 1740 gaagggagtg gcagaatcaa attgctacat agtccaaaca aaaaagaagg ctttttcaaa 1800 aaacattaaa ttcacatgca gtctcagaga ctttttagac aaagttcaag ttaggagctt 1860 ttaggatgtg ggagtaaaac tttaatggga ggggagggct ggctgctgga agaaggaaga 1920 agccagactg gttagacagt actcttaact cctagcccag cctagcgtgc cctgcccctc 1980 tggccactgc tgcagacacc tgccttaaca cacacacctc taggactcca cagttttgcc 2040 ttaaaggacc ttcccaagtc tccctttccc tgtctggctt ctcccttaag aagagagaga 2100 tacttgtaga attgggtggg gggaatgagc atgaactgtc cttccatttg ggatatgtta 2160 cattagagtg agagagagaa taaggagcct ttcttatgga agaaatggga gaagagagac 2220 agggttcttt tcagcagagt ctagtagttt ctctgtaagg caaaataatc taaaaagact 2280 aacctgccca cccactcctt atattgctgt gagattgccc ctatcttgtg ctcttctgtc 2340 tgcagtgtgc acggccttgt tctaacccgg aataaaggtg attga 2385 <210> 56 <211> 1689 <212> DNA <213> Homo sapiens <220> <223> Genbank Accession No. U32680 <400> 56 cccctagaca agccggagct gggaccggca atcgggcgtt gatccttgtc acctgtcgca 60 gaccctcatc cctcccgtgg gagccccctt tggacactct atgaccctgg accctcgggg 120 gacctgaact tgatgcgatg ggaggctgtg caggctcgcg gcggcgcttt tcggattccg 180 agggggagga gaccgtcccg gagccccggc tccctctgtt ggaccatcag ggcgcgcatt 240 ggaagaacgc ggtgggcttc tggctgctgg gcctttgcaa caacttctct tatgtggtga 300 tgctgagtgc cgcccacgac atccttagcc acaagaggac atcgggaaac cagagccatg 360 tggacccagg cccaacgccg atcccccaca acagctcatc acgatttgac tgcaactctg 420 tctctacggc tgctgtgctc ctggcggaca tcctccccac actcgtcatc aaattgttgg 480 ctcctcttgg ccttcacctg ctgccctaca gcccccgggt tctcgtcagt gggatttgtg 540 ctgctggaag cttcgtcctg gttgcctttt ctcattctgt ggggaccagc ctgtgtggtg 600 tggtcttcgc tagcatctca tcaggccttg gggaggtcac cttcctctcc ctcactgcct 660 tctaccccag ggccgtgatc tcctggtggt cctcagggac tgggggagct gggctgctgg 720 gggccctgtc ctacctgggc ctcacccagg ccggcctctc ccctcagcag accctgctgt 780 ccatgctggg tatccctgcc ctgctgctgg ccagctattt cttgttgctc acatctcctg 840 aggcccagga ccctggaggg gaagaagaag cagagagcgc agcccggcag cccctcataa 900 gaaccgaggc cccggagtcg aagccaggct ccagctccag cctctccctt cgggaaaggt 960 ggacagtatt caagggtctg ctgtggtaca ttgttccctt ggtcgtagtt tactttgccg 1020 agtatttcat taaccaggga ctttttgaac tcctcttttt ctggaacact tccctgagtc 1080 acgctcagca ataccgctgg taccagatgc tgtaccaggc tggcgtcttt gcctcccgct 1140 cttctctccg ctgctgtcgc atccgtttca cctgggccct ggccctgctg cagtgcctca 1200 acctggtgtt cctgctggca gacgtgtggt tcggctttct gccaagcatc tacctcgtct 1260 tcctgatcat tctgtatgag gggctcctgg gaggcgcagc ctacgtgaac accttccaca 1320 acatcgccct ggagaccagt gatgagcacc gggagtttgc aatggcggcc acctgcatct 1380 ctgacacact ggggatctcc ctgtcggggc tcctggcttt gcctctgcat gacttcctct 1440 gccagctctc ctgatactcg ggatcctcag gacgcaggtc acattcacct gtgggcagag 1500 ggacaggtca gacacccagg cccaccccag agaccctcca tgaactgtgc tcccagcctt 1560 cccggcaggt ctgggagtag ggaagggctg aagccttgtt tccttgcagg ggggccagcc 1620 attgtctccc acttggggag tttcttcctg gcatcatgcc ttctgaataa atgccgattt 1680 tgtccatgg 1689 <210> 57 <211> 925 <212> DNA <213> Homo sapiens <220> <223> Genbank Accession No. D26600 <400> 57 ttttttctgc taccgtgact aagatggaag cgtttttggg gtcgcggtcc ggactttggg 60 cggggggtcc ggccccagga cagttttacc gcattccgtc cactcccgat tccttcatgg 120 atccggcgtc tgcactttac agaggtccaa tcacgcggac ccagaacccc atggtgaccg 180 ggacctcagt cctcggcgtt aagttcgagg gcggagtggt gattgccgca gacatgctgg 240 gatcctacgg ctccttggct cgtttccgca acatctctcg cattatgcga gtcaacaaca 300 gtaccatgct gggtgcctct ggcgactacg ctgatttcca gtatttgaag caagttctcg 360 gccagatggt gattgatgag gagcttctgg gagatggaca cagctatagt cctagagcta 420 ttcattcatg gctgaccagg gccatgtaca gccggcgctc gaagatgaac cctttgtgga 480 acaccatggt catcggaggc tatgctgatg gagagagctt cctcggttat gtggacatgc 540 ttggtgtagc ctatgaagcc ccttcgctgg ccactggtta tggtgcatac ttggctcagc 600 ctctgctgcg agaagttctg gagaagcagc cagtgctaag ccagaccgag gcccgcgact 660 tagtagaacg ctgcatgcga gtgctgtact accgagatgc ccgttcttac aaccggtttc 720 aaaccgccac tgtcaccgaa aaaggtgttg aaatagaggg accattgtct acagagacca 780 actgggatat tgcccacatg atcagtggct ttgaatgaaa tacagatgca ttatccagaa 840 ctgaagttgc cctactttta actttgaact tggctagttc aaagatagac tcttcttttg 900 taaagtaaat aaattcttca aaatg 925 <210> 58 <211> 86080 <212> DNA <213> Homo sapiens <220> <223> Genbank Accession No. AL008726 <400> 58 gatcagagta gtaaagggtg aggcagcatg gtaaaatggg gagagtacaa gccttgaagt 60 ccaaaaccca agatccaagg ccagcctctg cgagttgtgt gaccttgggc cggtagcagt 120 gcctctctga gccatttctt catctgtggg attggacctg tctgtggggt ctccctcaca 180 gagagaccat ggtaaatggg aacccgggta taagtcacct agcttgtgct gggtacacag 240 cgttggtgct tggcaagagg aatgtcccgt ctttgaacca tggtaagggg caggggatag 300 gaggagaaag tgacaggtag gccactgttt actgaacccc atgacgtgcc acacactgtg 360 ctaagcattt taacatgatc tcatctagtg ctcctcctat gaggtagcaa cgattatccc 420 cacttgactg cagagctttg taaattataa aggtctatac tcactctgtc accaaggctg 480 atgtgcagtg gtgctattat agctcactgc agcctctatc tcctgggctc aagtgatcct 540 cccacttcag cctcccgagt agctgggact agaggtgcac caccacccct ggcttttttt 600 ttttttgtat ttttatagag atggggtttc accatgttgc ccaggctggt ctcgaactcc 660 taggctcagg ggatccttcc accttggttt cccaaagtgc tagaattaca gtcatgaggc 720 accatgccca cccatgttga tgattcttat tattaatcct gactggaggg aagttgggac 780 agacagtcct tggggcacct gtccagatgg aaaaatgtat ggagggatgg aggagaggag 840 gatgtgcatt tggaggagaa ataatcattg aaagcaaaga tccttctctg aaagttacct 900 tctccaggga aagggtgttt ggattcactt tttttgaagt aaggagtagg caggggaagg 960 ttctttaagt ggtaaaagga cagctggccc cttcctagag ctcagtgaag aaatctggtc 1020 atctggggag taaaggggtg ggcagaccaa gtccagaggg agcccaacct gagaatccac 1080 aaggtgcagg ctgggcactg gggagtaggc aaggcttgta gacagtggct acgtggacag 1140 aaagagcacc aagacaaccg atagcaggct ctggggccag gaaagggggg ctggacacca 1200 aggaatgcag atggacagtg gcaactgggc tgcccccttc ccctatatat agacattccc 1260 aaggaaagct cagcagggct gggccaagct aaataaggcc tcccccaggc aggcagggtg 1320 ccaaagggtg agggagaccc atgggattcc aatttagttt ttattgtttt ttggtttttt 1380 ggggttttgt ttttgagaca gactctcact ctgtcaccca ggctggaatg cagtggcaca 1440 atctcggctc actgcaccct ccgcctccta ggttcaagtg attctcatgc ctcagccttc 1500 tgagtagcta ggattacagg cacataccac tacgcccagc taatttttgt ttttggtttt 1560 tttttttttt tttttttgag acagagtttt gctcttgttg cccaggctgg agtacaatgg 1620 tgcaatctcg gctcaccaca acctccgcct cttgggttca agcaattctc ctgcctcagc 1680 ctcccgagta gccggaatta caggcatgag ccaccatgcc cggctaattt tgtattttta 1740 gtagagacag ggtttctcca tgttggtcaa gctggtctca aactcccaac ctcaggtgat 1800 ccgcccacct cagcctccca aagcactggg attacaggtg tgagctacca cacccggcaa 1860 attttttact ttttgtagag acaaggtttc atcgaccggg cacggtggct caggcctgta 1920 atcccaccac tttgggaggc tgagatgggc ggatcacgag gtcaggagat cgagaccatc 1980 ctggctaaca cagtgaaacc ccatctctac taaaaataca aaaaaattag ccgggcatgg 2040 tggtgggcgc ctgtagtccc agctacttgg gaggctgagg ctgaggcagg agaatggtgt 2100 gaacctggga ggcagagctt gcagtgagcc gagatcacac cactgcactc cagcctgggc 2160 aacagagcaa gaccccgtct caaaaaaaaa aaaagtttca tcatgttggc caggctggtc 2220 tcaaactcct gacctcaagt gatccgcctg cctcagcctc ctaaagtgct aggattacag 2280 gcatgagccc ctgagcccag cctttgttct tttgtttatt caagggatta ggtaaggccc 2340 aaattgctta atgtagccaa gcaaggtccc attggccctt ctaatctcac tccttccctc 2400 cacatcatgt tgctgtctgc tctgatcaga ctttaaaata ctgctctagg ctgggcacgg 2460 tggctcatgc ctgtaatccc agcattttgg gaggtgcagg ctggcagatc acgaggtcag 2520 gagttcgaga ccatcctggc cagcatggtg aaaccctgtc tctactaaaa atacaaaaaa 2580 ttgctgctgg gtgtggtggt gggcgcctgt agtcccagct acttgggaag ctgaggcaga 2640 agaatcactt gaacctggca ggcgaaggtt gcactgagcc aagatcatgc cactgctctc 2700 cagcctgggc gacaaaagga gactgcatct caaaaaaaaa aaaaaaaaaa aaaagactac 2760 tctaaacacc accttctatg aaccttcaag cctttgcaca tgctgttttt ttctgccaga 2820 aactcccatc tttcctctct tcatctgtct acttccctat catctttcta agctctaaca 2880 tcacttcctc ggggatcctt cccccactgt gtccagacca gggagtccaa ggtggtctct 2940 agtagtttcc tcaatcatag cactgagcat accttatgct cacaacccat tctatgttct 3000 acagatcatc acatttccca gtgctcagca cttgctatgt agcaggtgtt caacagatat 3060 tatattctac ataagaataa ctgaactgga tggtatttag ttcaatataa gggggaactt 3120 cctaatagtc atagttgaac aataatggga acaggtggcc tcaggaggta atgagctccg 3180 tatcactgag tatacccaaa caggagctag atgaccattt ctcagggagg ctgtagggag 3240 atatccatac agaatttaag aatgggggca gtggctcaca cttttaatcc tagcacattg 3300 ggaagctgag gcaggtggat ctcttgagcc caggagttca ataccagcct gggcaacatg 3360 gcgagacgct gtctccaatt aaaaaattaa aataaaacaa agaatggtgg gtggtagctc 3420 atacttgtaa tcccagcaca ttgggaggca gaggtaggag gatctcttca ggccaagagt 3480 tcaagatcag cctgggcaac atgcaacccc acctttacaa aaaataaaat actagccagg 3540 catggtgggc acatatctgt agtcccagat acttgggagg ctgaggtggg agaatcactt 3600 gagcccagga gtttgaggct gcagtgagct atgatcgcac ccctgcactc cagcctcaca 3660 acagagtgag actctgtctc tgaaagaaga ggccgggcac ggtggctcat gtctctaatc 3720 ccagcacttt gggaggctga ggcaggtgga tcatttgagg tcagcagttc gagaccagcc 3780 tggccaacat ggtgaaaccc catctctact aaaaatacaa aaattagccg ggtgtggtgg 3840 cacatgcctg taattccagc tacttgggat tacttgtaat tccagctact tgggattact 3900 tgaggcagga aaatcgcttg aacccaggag atggaggttg tagtgagcca agagtgtgcc 3960 attggactcc agcctgggtg atggagtaag actctgtctc aaaaaaaata aaataaataa 4020 aaataaataa aaaaggaaga agaagcagga ggaggaagaa ggaagcaaaa agaagaagaa 4080 ataataatag tggagaatgc gcaaccttca gatctcctag ttctgactgt ttatatgacc 4140 cagcataagc ccttcccctc actaagcctc agactaccta tctgtaaaat ggaggtgata 4200 ggccagattt ctgaggggcc ctcctgctct aacaacccat ggtttcatga agaccagctt 4260 tgtgcccaga catgtaaggc atataccgaa ggacaagtta ttttttaacc aatggttggt 4320 gaatgagtga gtgttgaatt aatgaatgaa gtatgccttt tttgtcccaa tatcttgccc 4380 ataagccaaa tgaagagtaa ttcgaggttt gaaattgtgc aaactggcca ggcacagtgg 4440 ctcacgcctg taatcccagc actttgggag gtagaggcag gtggatcact tgaggccagg 4500 tgttccagat cagcctggcc aatatggtga aaccccacct ctactaaaaa tacaaaaatt 4560 agccgcatgg tggcacatgc ctgtagtccc agccactcag gaggctgagg caggagaatt 4620 gcttgaacct gggaggcaga ggttacagtg agccaagatt gcatcactgt actccagcct 4680 gggcgacaga gcaagactct gtctccctct ctaaaaataa ataaataaat aaataaaatt 4740 gcacaaactt aggcttaaaa tcccagcccc tctatttccc agatgtggat cttggggaag 4800 tcactttgcc tcagtttctt catcttgaaa atggaccatt aatgtccagt tacagcctct 4860 tccccaggac gctgtgaggg agagatgtga cagtaaagtg cctagagcag gatgtagaaa 4920 gtggaccctc agaaaataag aaccccagcc tttctgctca catgggaggg cagggagctg 4980 aaataccttc tgcttatccc aaggcatttt cccccaccct tctctcctgt gccactcaga 5040 aagggtagga gctactttgg agagattttg attttattta ttgtattgta taactatcaa 5100 aatctgccct aacaactgat acctaggctt tgtgacagga agccacaata actttttctt 5160 gacctgcagc tgccctgcgg ataaaagata aaacaaagct ggggagccac tgagattatc 5220 aggcctgctg cacaggaaaa gggcagtatg cagcagggga cctgggctcc aggccccata 5280 ctcagaaacc tctgagggag gcagaggcag gtggatcact tgagcccagg aattcgagac 5340 cagcctgggc aacatggcca aatcccatct ctacaaaaaa tacaaaaatt agctgggtgt 5400 ggtggcgaac gcctctattc ctagctactg gggaggctga ggtgggaggg atgacctgag 5460 cccagggagg cggaggttgc agtaagcaga gatggtgcca ctgcactcca gcctaggtga 5520 cagagtgaga ctccatctca aaagagaaag aaagaaagaa agagagagag agaaagaaag 5580 aaagagagag agagaaagaa agaaagaaac ctctggcaag ctgtgtggtt aagccaagta 5640 actcaccctc tctggtcctc agtttccctg tttgcctact tcccatgtgt gaggttcaaa 5700 tcagattgtg caagcctgtg aacactgtag aaacaataat cattatgtaa gtgatcattt 5760 cgtcagcctt tgctctatgc caggcacggg acgagcgttc ttacaagagc tgcaaaatta 5820 gttttagcag tattgttcct gttttacata tgagaaaacc taggctcagc gaggtcagat 5880 tccaaccaac ccaaatcacg catcttctcc tggcccttcg ttttctctcg ggagacatgg 5940 cctccctact attgcataat tactttgtga agttaaagag cgttgggtgg aaatgagtgg 6000 gacagattgg agatgacgtg ggtggggtgg gaggattcaa ggagggtacg cgcctggccg 6060 gactgggatg actctgcggc aggcctggga ctccctcagg ccgacccagg cttcccaagt 6120 ccctcctgga gccaagggcc cgggattctc gggcggctcg ggcgagcggg cggggcagga 6180 ggcggggcgg cggcaggaag ctgcccgagc ggcgctctga gcggcctgag cccggcggag 6240 ccctgcagaa cccggccgac ctccatgggc tgcggggggc tgcacccgga cccctggggc 6300 gcggcgcgcc cctgaatgca ccgtgggacg caggaggtag aggcgcacga ggcggcgcaa 6360 gagacatcgg gagggtcctg agcccctccg gggaggaacg cggtcctagg ctgagtgggt 6420 tggggggaaa gcgatgctgg ctgggtcccc tggttcgcaa gacctcggac tgccaggggg 6480 tggggcctca ccgcgcccct ccctctccgg ttcgggcccc gcccctcctc ctcctgcgcc 6540 gggctggggt acccctcctc cgggatccgg tacacagcgt cgcgcgctcc ccccagggtg 6600 ccatggcctc ccggctcctg caccggctgc ggcacgcctt ggccggcgac ggccccgggg 6660 aggcggcggc cagtccagag gccgagcagt ttccggagag ctcagagctg gaggacgacg 6720 acgccgaggg cctgtcctcc cgactcagcg gcaccctcag cttcaccagc gccgaggacg 6780 acgaggacga cgaggacgag gacgacgagg aggctggccc tgaccagctg cccctcgggg 6840 atgggacgtc aggagaagac gcaggcgagt gcaggaggac ggaggcggga accctggggc 6900 tcgattaggc ctccatccca gccgcgttcc cagagcatcc agggcgctaa gttgatccag 6960 ctgaaactcc cacacttctt aaagcgcctg ggccacctct tggctgtgtg accttgagag 7020 agtcttaacc cccctctgag ccaagttttc ccttgtgtca agtgggagaa ctcactctca 7080 tctcagaatt gctgcaggca ttaaatgtac agggcttggg atccgaatgg aaatgatgta 7140 ttaacgatat tttgagggtg gagctattaa tttagcccct actgtctgcc aggcacggtg 7200 tttggctcct cggtgcctct ctgtccctca gtttccattt ctgtaaaaag ggggtaagtc 7260 ctgcctcaca ctgggaggat gagtgaggcc acgtcagtgg ttgatgtcga ccctggccct 7320 aggcccattg atatgactgg tcatgtgtct gcagaacgga gccccccacc tgatgggcag 7380 tggggcagtc agctcctggc gcggcagctg caggatttct ggaagaagtc ccggaacacc 7440 ttggcacccc agcggctgct cttcgaagtg accagcgcta acgttgtcaa ggacccgccc 7500 tccaagtacg tggtgagtga gggtctagaa cccctgggct gtgagtccag aagtatggct 7560 aggagcaagt agggaagacc ccaacttcct gaggggtcta tgtagttata aatggttacc 7620 ttgtttacaa atggggaaac tgaggtcaga aaggggatgt aacttgagca aatcctcaca 7680 caagacttag tttccttgag actgactgaa gtggggatta aggaccttcc tcttaacctg 7740 gttttgagac taagagaact ggtgtgtgca cttccccacc cagcccacaa ggtttttgca 7800 aattgtagca agatgtgaga tacagagaga cagatgttat ctgggtcaaa cttgagatcc 7860 aagttgcatg ggctggtagt taaggaaata ggctttcgat ccagaccaat cttgactccc 7920 acttatttcc agttgtttga ctctgggtga gttgtttaac cttggtcatc ttccgtttcc 7980 tcattatagc aatggggaaa atgcagaaga ttacagcagg agttaaatga gacaatggac 8040 aaaaagccct tagcagtgtg cctggcatta tgacgtggtc aatgaaatgg tagctatgtc 8100 atcattattt aactttgggt tgaaaatgtt tgtcatctag ggcctgctgt gtccttataa 8160 cgcacaggtc aatcagttct caagcacccg accttgtccc taagggctag acttagaggg 8220 ttggtggagg ttaggatgaa gagcaatgtt ggggaggacc ttggagtccc ttgctgtttt 8280 ccttgctgtt gagagactga cttggagaat gaggtctgct cctttaatgc ccacagcgac 8340 tcctgctcca gtcccttttc aggccaggcc tgaaagccag ctgagctggc cactcctgtc 8400 agtggcagct ctccatctct cactcccctc ctcttcacca cccttctcca cctctgactc 8460 agcaggaggg ggcctggagc ccagtcccac atctgggcct ctccaccctt ttctgttgct 8520 gttagtaagc aagggccaca cccatggggt gactactcca atttcagcag ggaccgactc 8580 cgattattga gtcttttaaa aaaatttttg aggccgggcg tggtggctca cgcctgtaat 8640 cccagcactt tgggaagccg aggcgggcgg atcacgaggt cacgagacca tcctggataa 8700 cacggtgaaa ccccgtctct actaaaaata caaaaaaata gccgggcatg gtggcaggcg 8760 cctgtagtcc cagttacttg ggaggctgag gcaggagaat ggcgtgaacc caggaggcag 8820 agtttgcagt gagccgagat cgagccactg cagtccggcc tgggcaacag agcgagactc 8880 cgtctcaaaa aaaaaaaaaa aaaaaaaaaa aaattttgag acagggtctc gttctgtcac 8940 tcaggctgga gtgcagtggt gcagtcataa ctcactacaa cctccaactg ggctcaagct 9000 atcctcccac ctcagcctcc caagtagcta ggactacagc tgtgcaccac cacgtgtggc 9060 caatgatgaa gtctgaagtg gcaaaggtct cagaactctg ggttcataca ctggaagggg 9120 acaccaagga atagttcaga ggctgagagg aatgggggtg actgtgggta cctggatggg 9180 aagggatgac aagatagagc aggatggcca agtatgcccc ggcctgtgtc tggagaagca 9240 aggcacctcc tgtgtacaat ggggacccta attccccact caacttgtgg gggtgaagag 9300 cacaggcttt ggaatcagat caacctgagt ttaaatccca gctgggctgt tttccagctg 9360 tgtgacttac ggcaagtctt tgagcccttt tccccctctt tgagcctgct tcctcagctg 9420 tcagagataa ggaccttcct tgcagtgctg ttgtgatgat taaatgaaat cacagatgta 9480 aagagtgctt ggtacaacag gaggcacagg gtaaatgctt gggtaatgga actactgtca 9540 ttatcaccca tctggctgca tgttacaagg tcaatgagat aatggataca aaatgtaaac 9600 tagatgaaca taaaggctta ttatatagac cagtgtgtcc tgaagaaaac tggtgtccta 9660 aagtgtgtcc tgcagaaaac tagttccctg gaatgttaat agctgtttct aaataaaggt 9720 tttgcaggca atatgttttg agaatgcaga gttaaatgag aatacaataa gtttctttat 9780 tgttaaagta tttaatccct aatagtgata tacactgtga atcttcaaga ggacagagta 9840 agcaaaccta actgaccagg agtggctaga gtattgtcag ttccacagaa caaatgtgag 9900 agaaagatct ggatttggtg ttagggtgcc tttaacatct aacactggtt aactctcctt 9960 ttaaacctgt tggcttggca ttataggtta atccatattc aggttctcag acctgggagg 10020 cggggaactt cgtgatcatc ttgttcagtg ttttccaaac ctcagtcatt ccaatacctc 10080 cctgattctt gtcctatcta aaaatgccac ttgtgtcctt ttcttcttaa catttttctt 10140 taaatgaacc tatttttttt tctttatctt tttttttttc ttttttgaga cagagtcttg 10200 ctctgttgcc caggctggag tgcagtggtg caatctcagc tcactgcaac ctccacctcc 10260 taggttcaag caatcctccc gcctcagcct cctgagtagc taggattaca ggtgcccacc 10320 accatgcctg gctaactttt gcattttcag tagagatggg gtttcactgt tggccaggct 10380 ggtcttgaac tcctgacctc aagtgatctg ccgcctcagc ctcccaaagt gttgggatta 10440 caggtgtgag ccactacgcc cagccgaacc tatttttttt cttaaataag tttatcgaga 10500 cggagtcttg ctctgtcgcc taggctggag tgcagtggcg tgatcatagc tcactgcagc 10560 cttgaactcg tgggctcaca tgattctctg cctcagcctc ctgagtagct gggaccacaa 10620 gtgcccaact aattcttttt ctttttcttt ttcttttttt tagagacagg gtcttgccat 10680 gttgcccagg ctggtctcga actcctggcc ttaagctgtt ctcctgcctc agcctcccaa 10740 agtactggga ttacaggtat gagccactgt gcccatcctt taagtaattt taaaagacaa 10800 cttcatagca ctaccgtacg tggaaagtct cacttgccac cgagagaagc tagccataaa 10860 aataaaaggt gaggcacggt ggctcacacc tgtaatcccc gcactttggg aggctgaggt 10920 gggcagatca cctgaggtca ggagttcaag accagcctgg ccaacacggt gaaaccccga 10980 cactactaaa aatacaaaaa ttagccggat gtggtggtag gcgcctgtaa tcccagctac 11040 tcgggagatt gaggcaggag aattgcttga acccaggagg cagaggttgc agtgagcgga 11100 gattgtgcca ctgcatgcca gcctgggcga cagggcgaga ctaaataaat aaataaagta 11160 aataagtaag tagtgaaaat gaaacgtcat taaatcttgc ctagatgttg ttgcctgaag 11220 gaggccctga cctgagatcc actttctgac tcttttctaa aaatggagat gagaagtgtt 11280 agagaagtac tttttttttt tttttttgag agagagtttc actcttggtg cccaggctcg 11340 agtgccatga gcaatctcgg ctcaccacaa cctccacctc ccaggttcaa gcaattctcc 11400 tgcctcagcc tcccaagtag ctgggattac aggcatgtgc caccacgcct ggctaatttt 11460 gcatttttag tagagacagg gtttctccat gttggtcagc ctggtctcga actctcaacc 11520 tcaggtgatc cacctgcctc agcctcccaa agtgctgaga ttacaggtgt gtgtgtgagc 11580 cactgcaacc tgcccaagaa gtcctttttt taaaaccaaa ctgagagctg gccaggcgcg 11640 gtggctcaca cctataatcc cagcactctg ggaggcaaag gcgggcggat cacaaggtca 11700 ggagatcgag accatcctgg ctaacacagt gaaaccccgt ctctactaaa aaatacaaaa 11760 aattagccgg gcgtagtggc aggcgcctgt agtcccagct actcgggagg ctgaggcagg 11820 agaatggagt gaacccagga ggcggagctt gcagtgagcc gagatcgtgc cactgtactc 11880 cagcactcca gcctgggcaa cagagcgaga ctccgtctca aaaaaaataa aaaaataaaa 11940 aaaccccaac aaaaccaaac tgagagcttc tcaatttgta gtcagaaaga ttaaaaaaca 12000 attaggctgg gtgtggtgct catgcctgta atcttagcac tttgggaagc ctagctagga 12060 agattgttca aggccaggag ttcaaggcca gccctagcaa catagtgaga ccccccctca 12120 tctccataca aaaaaaaaaa aaaaaatttt tttaaatagc tgagtgtggt ggtgcatgcc 12180 tatagtccta gctacttggg aggctgaggc aggaggaatg cttcagccca ggaggttgaa 12240 gctgcagtaa gctatgattg taccagtgta ctccaacctg gccaacagtg agaccctgtc 12300 tcaaaaaata ataattaaaa ggggaccaac ctcctgatac agtgatattt actctagtgc 12360 acaccaccta aaaacctcag gtaccaatac ttgtacatgt ctcatttttg gacaaacact 12420 gacttgaccg agcacttcct tcactagaaa cagaagtgga cccagagggg gactcccttg 12480 cctgggtcac acagagaagg agtagctgac ctggggttag aacttgagtc ctaggccagt 12540 atacttttca cagttatggc agttgtggct atctacagac ctgtcctctg ggtctagttt 12600 ggaaaagcct gaccagggat gtggaggcca ggtgtccaaa gtggaacaag ctccaagctg 12660 gtcctaaagg agccccaaga gattggctgg ggtttcagct tatgtctggt tttccagagg 12720 gggctgtcag aagaactaat gctctatggg aagggagtac aaaaaaaggg gcagcagccc 12780 cgggcactga agctcatctc tgtctttctc tcttcttgct gccttgggcc tgggtcattt 12840 cagacaaacc tcaggtaaga tgggactggg cttccccgcc actgcgcagc agctcccgcc 12900 ctcctgggtg ctgtcccagg ggtgaaagga agaggtgggg aggtacagct gggagtgtgg 12960 gggatgggga aggatgggga gggaacgggc ccgtggacaa cttgcatttg ccctgacacc 13020 caccctccct gcagctctac accctcgccg tgatcggccc aggaccgcca gattgccagc 13080 cagcccagat ctctcgccgt tactcggact ttgagcggct gcaccgaaac ctgcagcggc 13140 aattccgggg cccaatggct gccatctcct tcccccgtaa gcggctgcgc cggaatttta 13200 ctgcagagac cattgcccgc cgtagccggg cctttgagca gtttttgggt cacctgcagg 13260 cagtgcctga gctgcgccat gccccggacc tgcaggactt cttcgtgctg ccggagctgc 13320 ggcgggcaca gagcctcacc tgtactggcc tctatcgtga ggctctggca ctctgggcca 13380 atgcctggca gctgcaagcc cagctgggca ccccctctgg cccagaccgc cccctgctga 13440 ccctggctgg gctggccgtg tgccaccagg agctggaaga ccctggagag gcccgggcat 13500 gctgtgagaa ggccctgcag ctgcttgggg acaagagcct ccaccctttg ctggcaccct 13560 ttctggaggc ccatgtccgg ctctcctggc gcctgggcct ggacaaacgt caatcagagg 13620 ctcggctcca agccctgcag gaggcaggcc ttacccccac accacccccc agtctcaaag 13680 aattgctcat caaggaggtg ctggactaac ccttgcctag atttaaggcc actgtgagga 13740 gaggggttgc cccagaaggc aggggaagga cctgatgaga acagaatagc tgggaggctg 13800 cagagggtgc tgggagcccc tagaagttcc aaaagagaat gtgaagcaga tcaaggaaac 13860 ttctgttgag ctaggctcag ggtgagcttt ggctggggtt gcccttgtgt agtacaggga 13920 agtctgacac agcctctcca gcctataaac agccgggggg ctgtggcaca ggttggggca 13980 atgttccctt gttggtgggc ccccaagctg gcaaggcctc ttggctgaag gccagggact 14040 ctgcccctgg agtcctggag ttaagggatg aaggcaaggc tgcaggtctg gcccagggga 14100 attaaaagcc agccactcca gtggtatcag tctctttatt ggatgtgagg gccaaaaggg 14160 actgtaactc ctgtctcagg aatggggata gatgggaggt tcttgaagcc ccaggcgaag 14220 ctggtacctc tggctacagc ttgctctctg agacctgggg cttcactcgg atcacgccct 14280 cctgggcaca ggtcacagct aggactccat cctgacgcca cagccgccca tggaccagcc 14340 cccgagagcc acctgtgggt gaggtgaagg gtgatgatgg cctgcttcag aacagccaaa 14400 tacacttttt ttttttttcc tgaaacagag tctcactaag ttgccaggct ggtctcaagc 14460 gcctgggttc aagggatcct cccgcctcag cctcctgagc agctgggatt acaggcgcac 14520 atcaccatgc ccaacctcca agtggacttc ttgcaaaggg tctggcccag ggcagggctg 14580 ccccacacaa gggtgcactg agtgtcgtgg ctgctccaaa tgccccttca tgagcttatt 14640 atggaccgtc attgaggggt aactcctccc acaggaaccc cagttgacag tttaaaagca 14700 ctttcacacc tctcctcgct tcctcaaaaa gatcacagag ggaggagctc tgagaacagt 14760 ctccttcaac agttcggcca agcagaactg ctgtacctct gaccacttgt gttaggaaaa 14820 ctatcggctc cctgtataat aaatcaagcc aggtcctcca agtggtaatt catgaaaaat 14880 atccccacta ccaccaccaa ggggaagaaa ggactcagaa gagaggactt gaggccatga 14940 ggtctggcct cttccctccc catctggaga ctctttctcc cttgctggct ttgggcccaa 15000 gtttgatgtt tatgaggatg attgctggtt tcccttacac atagcagagc tcactcagtt 15060 ctcacagtag ccaaatgaag cagttatgtg ttgtccagtt ttccagacca ggactgaaat 15120 ccagagaggg tcaggaattt ggccccatga tgaagccaaa tctgaaccca tgtcctcact 15180 tcaaggttat caatcttgga ttgtgatgct attggtactt gagaataccc cttatctgag 15240 tataaagaat ccttgagttt tgtccttggt ttatcaagca aagcttttct tcatttgaaa 15300 tgtactccct tggaaaggag gtcagggttc tgaagctaga cattgatgaa cgagtcttgt 15360 ttctctcccc tgcaaggaag gtccaagcag gcccttaggg accactgaat gccccgatcc 15420 caatcaggtt aatcagaatc acttagagaa cttaaaaata cagtttcctg gaccttatcc 15480 aagacctact gagtgagaat cttgagggtg gaatcagaat ctattttgaa aaggcatccc 15540 caaatggcag tctgatggac tgcgggtttg gataccactg ctgtaatgta accctctttg 15600 tttagatgag gaaactgagg ttcagatgga agatatgatt tgcctattgt aatacaaaga 15660 atctgaactg gttttgggac tagaactggg tccctgggag aaggtgaatc acatttccag 15720 cacattctag aaatttagag cagagcaggt gtcccggcct caccctctca ttttgaagat 15780 gaagatgcca aagcctggga gggaaggaaa ggaagtgacc tgtgcagcgc cacacaggaa 15840 gtcgggaaat cagcatcacc caagaaagca ggctcctgcc actcaaggtc agtgcccttg 15900 tcccacacgg ccccacactc accggcccag gggctctcgc attcatagag catccagtgg 15960 tcagctcgga agggggcgtg gaaccacatg gaatggtcca gtgagaccat gaagtgcacc 16020 ttgtgctgcc actggtgagg cagcagtgca gtgcccaaga aggcatagtc ggagatatag 16080 gcggccacgc agcagtgcat cttcatgtcg ccctcgcctg caacaggtcc ccatcagccc 16140 tgggctcctg ggctttccag ctcaggacct gcacggaggt agggggaaaa gggactcccg 16200 tgcatgggtg tgcagactgg ttgctgcaca agagcgcttg gcctacagtg tgtgtgtgtg 16260 ataggggaga agtgagatgg cgacttgggg agggcagggg tgagcaggga ctgaaattca 16320 gtcttcacca cccaagtctc ccactctagg ccccaaaagg ggtgtcttct tccaatttgc 16380 acaaagatac tttatagtta gcagcaaagc tggacaacaa ccccagcgag gtgccttttg 16440 ccttcctcag aaaggccttg tgtcgggatt atagtcatct ccaccttctc cccatgcaaa 16500 gggctgagag ggcccaggtg agaagctaag ccaacttccc catcatgcag ataaggaaac 16560 aggcccagag aagggaactc atgtgcccaa ggccacacag caaatgagtg gtagacccct 16620 tggagagtgg tttcctccca tccatggggt actcttacca atatagcccc gggctcgcac 16680 ccagaacatc tgtttgggct ccattctctg cagctggctc aggggggatg ggtttactgg 16740 cttgatctca atggggacct cctgagcagc aattcggttg agcgccaatg ggtacctctt 16800 ttggaggtta gggtccctga aagtaaaggg aagagggtcg gggtgagacc caggaagaga 16860 gggagtcaca tctgcattgc ctcttctgac tcccctcatt cttccacagg gacccctgat 16920 atccccaaag ctcccctccc ctgtggcagg caggatagtg cagcgtttga atcccttctt 16980 ggccacttac gagccatgtg gtctcgtgct aattagtaat ctgagtctat tttcccatct 17040 gcaaaatgtg gataatgata gtaacctacc tcataaccaa cactgtgaag acaagatcat 17100 gaatatctaa ccaacacatc atagtaataa ggcataccct gtaatatgca ctgttctaag 17160 cattgtacat acaatagtat tcctcacaac aaccctgtga gataggtact attatcaccc 17220 ccatttcatc agtgaaataa gcacagagtc caggtagctt gcttaaaaat tggagagaca 17280 ggatttggac tcaggcaatc tgggtccaca gtatgattat tttctatttt tttagagaca 17340 aggtcgtctt ctcacccagg ctggagtaca gtggcgcaat cagctcactg cagtctccaa 17400 ctcccaggct caagccatcc tcttgccttg gcctcccgag tagctgggac tagaggtgta 17460 cgccactgtg cctggctaac atttttatta tttctttatt ttgagacgga gtctagctct 17520 gtcacccagg cttgagtgcg gtggtgcaat ctcagctgac tgcaacctcc gcctcccagg 17580 ttcaagtgat tctcctgcct cagcctcccg agtagctggg attacaggcg cctgccacca 17640 tgcccagcta atttttgtat gtttagtaga gatggggttt cactgtgttg gccagggtgg 17700 tctcgaattc ctgacctcat gatccgcccg cctcagcctc ccaaaatgct gggattattt 17760 ttactttttt ttgtagagat ggggtctctt tatgttgccc aggctggtct caaaatcctg 17820 gccttaagtg atcctcctac ttcagcctcc caaagtgctg ggattacagg agtgagctgc 17880 tgtgcccagc cacttcatta ttttaaacac tcaagaaaca ggctgcctga cttggcctga 17940 gttaccaaac cctacacagt agggaacatt gcatcccccc agggggagga gcccattcca 18000 aggaactccc ttcaatacag tgacaaccac ccatagtgct ctgcacaggt cctgccattt 18060 tcacccctat cctctggagt gctgttggac agaacctcct atgatgatgg aatgcctatc 18120 tgcacagcac actatggtag ccactagcca catgtgacta tggagcacct gaaatgtggc 18180 taatgcaact gaggaacaga attgttcatt ctactgactt tggttttttt ttgttttttt 18240 ttttttaaga cggaatctcg ctctgttgcc cagtcaggag tgcagtgact caatcttgct 18300 tactgcaacc tctgccccct gggtccaagc gactctcctg cctcagcctc ctgagtagct 18360 gggattacag gcacgggcca ccacgcctgg ctaatttttt tgtgtgtgta tttttaatag 18420 agatgaggtt tcaccatgtt ggccaggctg gtctcaaact cctgaccttg ggtgagccac 18480 ccgccttggc ctcccaaagt actgggatta caggcatgaa ccactgcgcc cggacctatt 18540 taattttaat taatgtaata tagccacgag tggctagaga ctaccttatt aacagcacag 18600 atctaaattc aaggtccttt aacaatgtct tcctttcatt tcagcaaaca tttgtcgaac 18660 tgcaaccaca caccaggccc tgtgtttttt ctgttaatag tgatataact acaattcact 18720 gccattgtgc tagttagtac tagcacgcta agtgcctttt ctctcttatt taatcctcac 18780 agcagcctta tgaggtagga atatgattag caccatttta taatggtgag tactggctca 18840 gagtgggaaa gcaacttgcc caaactcaca cagctagtag ggacaaaatc tagaattgaa 18900 tccaggcctt tcaggttccc aaacccacat ccatcccgtc atactctgct gcctccccag 18960 tatctaacac gagatagaga cattctctcc ttatgataca gctaagaagt aggcagggca 19020 gaaatgagca ttcccatttt ttagaagaag aaactagggc cctggggagt tgggcactgt 19080 cccacagcag gtgagcattc acagaggcac agccctggac agaatccatg tgtctatcct 19140 ttgtctggac ccagagctct ttcccctgta ccagcatttt tcaaacttga ttaggtgtga 19200 tccaaataaa tatattttac caggtattca aaatatctaa catgctccct ggtggtctaa 19260 tggttagggg aaaatacata tttgtatttt tgtacatatg ttttatatac ataaaacatg 19320 tggccgggca cggtggctca cgcctgtaat cccagcactt tgagagacca aggcaggtcg 19380 atcacttgag gtcaggagtt caagaccagc ctggtcaaca tagcgaaacc tggtctctac 19440 taaaaaaata caaaaattag ccaggcatgg tggcatgtgc ctgtaatcac agctgcttgg 19500 gaggctgagg cacgggaatt gcttgaacct gggaggcaga ggttgcagtg agccgagatc 19560 atgccactgc actccagcct aggcaacagg gcgagactct gtctcaaaac aaacaaacaa 19620 acaaaaacat gcactaatgc aaaggcagtg accaaacata ggccatagcg ctgcagctct 19680 ccagaggaca ctcactcctg gtgtgcatta agtcctaagt tgctggacca ggggcctggg 19740 ggagagaggg aatcacttag ggggctgggg aggtggtact taacaagtgg ttacggaagt 19800 atttctatat acatatatat ataaaatata tatatggttt tttttcccag gtatggtggc 19860 tcatgcctat aatcccagca ctttaggagg tcaaggtggg tggatcacct gagatcaaga 19920 gtttgagacc agcctggata gcatggtgaa acgccatctc tactaaaaat acaaaattag 19980 ctgggcatgg tagcaggtgc ctgtaatccc agctacttgg gaggctgagg cgggaggatc 20040 acttgagtct gggagtcaga ggctgcagtg agccgagatg gtgtcactgc actccagcct 20100 gggcaacaag agcaagactc catctcaaaa acaaacaaac atgtatatat ataaacaaca 20160 acaaaatata tattcttttt ttcttttttc agacagagtc ttgctcttgt tgcccaggct 20220 ggagcacagt aacacgatct cggctcactg cagcctccac ctcccaggct caagtgatcc 20280 ccccgcctca gcctcccaag tagctgggac tacagacaca tgccccgaca cccggctaat 20340 ttttgtattt tttatagaga cagggtttca ccatgttgcc caggctggtc ttgaactcct 20400 gggctcaggt gatcctccca cttgggcttc ccaaagtgtt attataggta tgagccccca 20460 cacccagccc cagccttatt tttaaattag agatggagtc ttgctatgtt ggcgaggcta 20520 gtatccaact cctggtctca agcaatcctc ctgccttggc ttcccaaagt gctgggatta 20580 taggtatgcg ccactgcacc cggccaagcc cttcatttta taccatgacc cagtacagac 20640 acacaccaga aacacacatg actaaacctc aagtttcaca aaaggattct tgcccttaat 20700 acatacatat tattcactcc agtatcttct tttctaatct gtattttaaa aatgctggtc 20760 aagacccact aaaggattct atgacccaca aacagatagc agctgcattt tgaaaagtct 20820 gccatggagc ctccaggtct ctcaccttaa atactggtca atgagggtct cacagtcaag 20880 cagctcttct ggtggtggca cagtgggcat ggagaactgg tgctgcatgg ggctgggctg 20940 ggcctgctgg aaggaggcct ggcagatgaa gatgggcttc ccatgttgca cggccttcac 21000 agagcgcacc gagaagctcg accctgttcg tgtccgctcc acttggtaca gtactggcag 21060 cttcgggtcc cctgcagtgg gcacaaggac acagtgggtc cacaggccct gtcatcatca 21120 caacgcctga caggcactct actactcatc ttccattcca tttcatctca gtgactacta 21180 actgaggtct gctaaggtcc aggcccaggg atacagagac caccaggccc tgtcatcagg 21240 cttctccctg tgcaggtgga gcttttctct aacagcacaa acagcagaga cattgacaga 21300 ttccttgcat tcaaatcctg gctccaccac tcaccagccg tgtgaccctt cacttctctg 21360 agcagtgtgc ttatttgcaa actggggatc atcatggtgc tcatcgctta caggatttta 21420 atgataatga aatgaatccg tagttgtaaa gtgtttagaa taatatctgg cacatagtga 21480 gggctctata tgtgtttgtt aaataaaatt aatactcctt gcttctatct tgctccatct 21540 atgcctggga tcttgtcatc agtccaaaac cattattcta gatcagggag cagtaaatct 21600 agcctgcagc ctgtttactg tttattctgt tgttgttttc ttttttgaga acaaacaaag 21660 gctatttatt cagcgcttgt tctttttttt gtttgtttga gatggagtct tgctctgtca 21720 cccaggctgg agtacagtgg tgtaatctcg gctcactgca acctccacct ctcaggttca 21780 agcgattcct gtgactcagc ctcctgagtg gggggggact acaggggtgc atgaccatac 21840 ccagctaatt tttttttttt ttttgagaga cagtttcgct gggtcaccga ggctgaagtg 21900 cagtggcgct atctgggctc actgcaacct ctgcctccca ggttcaagcc atgctcatgc 21960 ctcagcctcc taagtagctg ggactacagg cgtgcgccgc tacacccaac aaatttttgt 22020 attttttgta gagatggggt ttcactgtgt tgcccaggct ggtctcaaac tcctgacctc 22080 aactgatcca cccaccttgg cctcccaaag tgttgagatt acaggcatga gccactgcgc 22140 ccagccaatc agagcttgtt gtagcaggaa gtcaaccacc atcacttgct tttggcagag 22200 acttagaggc aggcaaagga atgggaatgc tctgtagtgg aaaaaaaggc ttcagggatg 22260 ctcccattgc aggctgttgg catggggaag ctgttggtgg gctaactaga agcatgacac 22320 ctggctgggc acggtggctc acacctgtaa tcccaacact ttgggaggct gaggcgggca 22380 gatcttctga gaccaggagt tcaagaccag cctggccaac atggcaaaac cctgtctcta 22440 ctaaaaatac aaaaaattag ccaggcctgg tggcacacac ctgtaatcct agctactcgg 22500 gaggctgcag caggagaatt gcttgaagct gggaggtgga ggctatggca ggagaactgc 22560 ttgaacctgg gaggtggagg ctgcagtgag ccgaaattgc accactgcac tccagcctgg 22620 ggaacaagag tgaaactctg tctcaaaaaa gagtgggaca tcctatgtga ttggttagga 22680 gtacatattt ggctttctcc ggttggtcct aagttggaag caggggcaaa aattagggca 22740 gctatcagtt attaatcaag tcctggcttt ggaggccaat tgttacagtg gtcattattt 22800 ggcttgctgg actggttggt aaagatagtg gtctgacttc ctacaagtct gacttgtgga 22860 tagtaggctg gcttcctgtg ctggttgctg ctattgtgcg tcagagttct gtttttctac 22920 atggtctagc cattgtctgt ttgtatattc agcctctccc aggcaagggc cactgtcagt 22980 cacttcaccc ctgatgtata tggaagccat ttggtccttc actgtcaggt gtctctgctc 23040 caaagcagag tggaagagcc taggcaacac agggagaccc tgtttctaca aaaaataaaa 23100 aataaaaatt agctggacat ggtggcatgt gcctatagtc ccagctaatc aagaggctga 23160 ggcggaagga tcacttgagg ccaggagatc aaggctgcag tgagccatga ctgcgtcact 23220 gtgctccagc ctaggtgaca gagcaagacc ttgtctcaaa aacaacaaga ccaccaccac 23280 cagagtagaa ggcactggcc agggataagg cagccaacaa caagcaggtg agggaagatt 23340 tggagaggaa gagaacttcc ctggtttccc tgaagttctc actttgtctg agtcaggctg 23400 accttgagga accctgacat ctgggccatg agacatcttg gggatgactt tcaaccttca 23460 gatgaaagaa gcaggtctag agaagtgttg cttccttcac tctgatccaa atggggagtc 23520 aaccaggcac cagggctcaa tcaacagcaa taaacatcac tgtctgaggt caactggctt 23580 gctcagctct ctgttatcag gcactgccac cagcagcact tctatcagag tgcgagctcc 23640 tcaaggttaa aggcatttga gaagggctta ccaagagtcc agacactaga caaagttact 23700 tgtgcagtct gctttcagac actgggaatg aagtcttcct ccctaccacc aaacttgggg 23760 ggaaaaaaca aaaaaaaacc tctaatccaa tccttggtct gcaggtaagc taaagtgcag 23820 attcctgagg aggatcacag aaacttcagt actctggtct acctttcagt gtgaatgagt 23880 tccagcccta ttcttgaaaa ttgttattgg aacagagcag gtaggccctg aggcatattg 23940 aagggagtta atgattatgg agtgatgcag ggtgcctgac agcattggac aggagggtat 24000 gttttctcat gttggtctca caataactat gtagagccac tcttaccccc attgtacaga 24060 tgaggaaact gttgccttaa aatacaattt ttttgtaata aagtcatgct aatttgttta 24120 catattgtct atagttgctt tcactggcaa aacctaaaat gtttactatc tggccctttc 24180 tagaatgttt gctgaccttg ttctgaattc ttcaagctct aaatttacct ctgtagagaa 24240 aaactaaaaa caaaacaaaa acccaactaa ttcacattct ttcctgggct tttagaaaaa 24300 gaactgattt gataaatggc caaggaccaa ccctccccct cccccataac atcttttatt 24360 tttaaaatgt aattgaaaca tctctttttt gttttgtttt tttgagatgg agtctcgatc 24420 tgtcgcccag gtgggagtgc agtggcgcag ttttagctca ctgcgacctc cagccgccgg 24480 gttcaagcaa ttctccttgc ctcagcctca gcctcagcct cccgagtagc tgggatcacg 24540 ggctaaggtc accacgccca gctaattttc cttttttttt ttagatggag tcttgctctg 24600 tcacccaggc tggagtacag tagcacgatc tcagctcact gcaacctcca cctccagggt 24660 tcaagcgatt ctcctgactc agcctcctga gtagctagga ctacaggtgt gcaccaccac 24720 acctggctaa tttttgtgtg tgtttttttt ttttagtaga gatggagttt cgccacattg 24780 tccaggctgg tctcgaactc ttgacctcag ccgatctgcc cgcctcggcc tcccaaagtc 24840 ctgggattac aggcataagc cacatgccca gccaaaaaac agcattggtt ttaatatctg 24900 atatagctgg cagagtcaca ccacaaacag ataagagctc tccccttttt gccttgcagc 24960 caggaagctc agaactaaac cttgtatgaa actgcaacaa tatggcttag ccaaattttt 25020 tgacatgatc gcttctccca aatcccatta ctactggcct aatgtccttt gacttttaat 25080 attcccataa taactaccaa ttattttagc tatcttgcag cctttcaaga cacaagcaag 25140 ggcacaaata attattttta tttatttatt tatttttgat ggagacaaga gtctcgctct 25200 gtcgcccagg ctggagtaca gtagcatgat ctcagctcac tgcaacctcc gcctcctgag 25260 ttcaagcaat tctcctacct cagcctcctg agtagctggg actacaggca catgccgcca 25320 tgcctggcta atttttagta ttttagtaga gactgggttt caccatgttg cccaggctgg 25380 tctcgaactc ctgagctcag gtgatccgcc cgcctcggct tcccaaagtg ctaggattac 25440 aggcatgagc caccacgccc ggccaaataa ttatttattt tgaaatggtg gcttggacac 25500 agctcatttc acgctgctcc tggatgaaga ctttccaaga aagaggatct tttccccaga 25560 acctgggatg ggtaccctgg cagctctctc attgtttaga attattgccc aagagcgaag 25620 caaagaagca ggaaagagtt tggcactcaa agacacataa accaggttca aatcctggct 25680 ctgcctcctt gggcactgtg ggagctggtt ccaaacctct tcaggtccca gtttccttag 25740 gtaagaatga tggcaggaat gcctgccacc catgtttact tatgaagact aaacaagata 25800 atgcacacaa ctatgctctg tatcatgcaa attttaatta ttcccataag ttaatcatca 25860 aaaactaata atatttatgg aaaactagat tatgccaagc cctgcactag atactttact 25920 ggcaaagact cattgaattc ttccatcaca ggatgaagag attcagagtt caagtaatgc 25980 ccccacccac acaaaagaaa acagccaggt atttcactag gctggaagga ttacaatatc 26040 aaaaggctgg tacttacaaa caaattaaag aaacaaagca catatttact cccaactagc 26100 ataaagataa gaacctggct gagcccaagg taagtattca aatactttat agcagtgact 26160 gggggccgag aagagggggg ccaatcaata ctcctcaggg atgaggagta agagacacgg 26220 gacagtatga aaaagtgtat ttaccattac agggataact ttcatattta caaaatgaag 26280 ggggaaaccc catggttttc ttaatacaaa tcacatactg taaaggtcca caaactcttc 26340 tcagctgggg atctacgcag aacacatgag ggcatctgct ctgggggtaa cagggaagga 26400 aagaaaacag tgagggtttt ttttgtttgt tttttagcat aggttttgct tttattttcc 26460 ttttatttat ttttttgtag agacaaggtc tcgatttatt gccctggctg gtcttgaatt 26520 cctgggttcc aacaattctc cgcattggcc tcccaatgtg cggggattat aggcatgagc 26580 caccacacat aggttttttg tttttgagac agagtctcgc tctgttgccc aggctggagt 26640 gctcgcccag gctggagtgc agtggcacga tcttggctca ctgcaagctc cgccttccgg 26700 gttcacacca ttctcctgcc tcagcctccc gagtagctgg gactacaggc acccaccacc 26760 acacctggct aattttttta tatttttagt agagacgggg tttcaccgtg ttagctagga 26820 tggtcccgat ctcctgacct cgtgatccgc ccgccttggc ctccaaagtg ctgggattac 26880 aggcgtgagc caccgcgccc ggcctcacac ataggtttta agttacatta tctgacccca 26940 gagctgtaag aagctgtaga gatcatccca ctaaaatacc cttggtccca cccttctcca 27000 ttttacagct gaagtaaacc aaactgtagg gcggggaggt aacctcacaa ggctgcatgg 27060 taaattatgg acaaaactga agctaggccc tacatctttg gtttgttttt attgacccta 27120 tgctcagttg acaaaagaag ccttagatcc cttgactctc aggctggtgc tctcttctcc 27180 aacccaagct gccctacctc cacacctcta gcacagaggt cacagcacac tgagaaccta 27240 gcacagcgct ccgcaccagg agctatgtta agaatggaag aacaaaagcc cacaaggagc 27300 agttaagcaa caaagtcttg tgtcattatc agccagacat caggtaccca gtgagtccca 27360 gcaggtgtga ggtccaaggc tcattgttag ccccagacct cgttccaccc tagacacctc 27420 ttagggtggt agtgtccgcc acccctcccc ttgtcttcca gtctccctct cttccctttt 27480 gacctcagcc cccaaggcca gaaatggctg ctgggccacc agggttgggt tggggcagga 27540 agtggggggt ttacctgccc gaacaaagta gcagtgcagg gagtgcacgt ggacgtcttc 27600 actcacagac ttggctgcag ccaccagggc ctggcccacg atctgaccac caaacagcct 27660 cttggccggt acccagtaat gccttcctct gtagggagag ggggaaagag ggaaagactt 27720 gggaactggg ccaaattcta ctaccctcac taagactcta atgcatgatc tcttcaccat 27780 attggggttt aagatccttt tgagaatatg gtaaaagcca taggtccttt ccccaggcaa 27840 atatccttat gcataaaaat cctctgggcc gggcgcagtg gcttacatct gtaatcccag 27900 cactttggga ggccgaggca ggtggatcat ttgagatcag gagttcaaga gcagcctggc 27960 caacatggtg aaactccatc tctactaaaa atacaaaaat tagctggacg tggtggcatg 28020 cacctgtaat cccagctact caggaggctg aggcaggaga atcacttgaa cccaggaggc 28080 agaggttgag gtgagccaag atcgcaccac tgcactccag cctgggtgac agagcaagac 28140 tccatctcaa aaaataaaat taaataaatg tataaatgaa taaataacaa gagccctcag 28200 acatcaagtc taactccttc agtgtacaga tgagaaaact gcagcttggc cccagagatg 28260 aaaatgcttg cccagaatgt aggcccattg gaagctgaat aattatgtct ctagcctccc 28320 acgtcccagc tgtttggcat tttctgtaac aatgagttat gaacagccct ccatgacctg 28380 gcaggtggct ctcgcctgta atcaatccca gcactttggg aagccgaggt gggaggatcg 28440 cctgagccca tgagttcaaa accagcctgg gctccaaagt ggggcctcat gtctactaaa 28500 aataaaaaag ttagctggat gtggtggcaa gcgcttatgg tcccagctaa acgggagact 28560 gaggcagaag ggtcacttgg gcccaggagg tcgaggttgc agtgagccat gttcgtgcca 28620 ctgcactcca gcctggacaa cagggccaga tcttgtcttc aaaaacaaaa atcaaatagc 28680 cctccaagaa gttatttaca attccttaag tggaaggaag ggagctcaaa gtaagataac 28740 ttccagtaaa gccaggagaa gccttggagg tcaaagctgt tagaagcctt gctgcagggg 28800 gctgggcgcg gtggctcatg cctgtaatcc tagcactttg gcagaggtgg gcagattaca 28860 aggtcaggag ttcgagacca gcctggccaa cacggtgaaa ccccgtctct actaaaagaa 28920 gttaaaaaat tagctgggct gtggcgcgcc tgtatgtccc agctaatcag gaggctgagg 28980 caggagaaat gcttgaaccc gggaggcgga ggttgcactg agccgagatc gcaccactgc 29040 actccagcct gggcaacaga gcaagactcc gcctcaaaga aagaaagaaa cccttgctgc 29100 agtcaagaac ttcagcgatg ctgggaaaga aaaaaacatg cttaggcctc agaataagta 29160 atgagaaacc agacccacca aatggtactg ggggcgggat attgtgagaa gaaaaggata 29220 ctgaagacac aaggagctgc ggcgtcggtt ttaaggctga tccatcagct gtgtgccctt 29280 gggcaaatca ctgccctctc tgggctagct cccccgtgaa ggcttagggc aggctgccga 29340 gcagggtctc tcaggtcacc actatatttg ctcagctgtg cagacctcgc agcgcggaga 29400 ggaagggagg aagccagagc agagaggaca gctctgttgg gggcgagttc tctcctaatc 29460 gtggcagagg gtgcatccca cgcagagcca tactagtccc ggagccaggg gccccgggcg 29520 gcggcagtca agatcaagtt tctgccctaa aggaggggat gctgggcagg agctgccggc 29580 tacctgaaga gatcctcgtc cagcggctcg aggttgagca cggtcgtgac caagacgcta 29640 cggaggtccc cagggggatc gccgcggtcg ccacagccct gcccatcttc tggggcctgc 29700 ggggacgaca tctagttcaa tgctgcaggc cctgcacacc cgctccgcgg aagacgcgga 29760 gacatacaca gaacctgact cttccggcag attgccctag taaccggaag tctcctgcag 29820 accccgggaa ggaggaatct aggttatgat tggtcaggac tcctgtcagt ccgctggtgg 29880 ctgtggccct ctttctctag caattggaga aaatgaatgc caatctgcga atcctgtgtg 29940 tgactggata tgtcgctgag gaggcggaac ctcgggactg gataatatgg actgagtgtc 30000 atttcccctg tcagatagca aatacacccc cttcctcttg taacccggtc aggcctaggg 30060 ttcctccctg agttccagaa taggccaccc agttggggcg gacccttaag gcattctggg 30120 cccacgcctg cctataaacc ctcatagtgt gacctttgac ccctggtgtg atcttgggcc 30180 cgggctggga ccagccccta gtgtgggttg tgggggcggc catggagctg ggcagctgct 30240 tcaagaccta tgaggacttc aaggagtgct tcagcgccta caaaagggag aacaggtgct 30300 ccttcattct cagggactgc gtctccgtcc gcttccacaa cctcaaccat ggcacctcca 30360 tccgcgaaga catcctgtaa gggcgggcgg ggcggggcgg gccaagaggg tggggaggag 30420 gctggacctc cggagggctg cctggaggag gaggggtgca taggcacgca ttgggctgcg 30480 tggccattca ttcaacaggc actcattgag cacctgctgt gtgccttgtg aagagagcta 30540 agcctccacg gccattggtt tttgaccacc cactccactt tcactccatt cacaggcttt 30600 tctggaattt ataactgcag tttctcccat tgttttgagc agctgcagca acccaaatac 30660 aaagtatggc tttcataaac ggataaaaac accttggcga taatttcctt catcagtctc 30720 ctctttacaa aacagtcaca tggtcgttgg aatgttcgtt cattcattca ttcagttttt 30780 agttcttata tatttgttga aacagggtct cactctgtcc cccaggctgg agtgcagtgg 30840 cacaatcagc tcactgagcc ttcaactgct gggctcaagc gatcctccca cctcagcctc 30900 tcaagtagtt ggaactggag gtgcacgcca ccatgcctgg ctaattattt gattttgtac 30960 agactgggtc ttgttatgtt ggctaggctg ttcccagact cctggactaa gcgatctttc 31020 ggcgtctcaa agtgttagga ttacaggcat gagccactat gcctggtcta ttcattcatt 31080 ttgtaaatgg tttttgagct ccttatatta accgttttca aacactttcc atgtgccagg 31140 cagtgttctc tatgcatgct ttaccctgca gggctttttt ttcagaatta tagataaatg 31200 ttattttttt gcatttgaca gatgagaaga tttgacagat gagaagtcag gcttagaggt 31260 taagacagga gttgaaaact caaatgcctt cagggattag gtgaaacaac ccaatgtaag 31320 aaagttttaa ctttgaattt tactttaaga aaaagaatga tgaaatagca accaacacca 31380 ggtctttgtg ctagggacaa cagaagtgtg aaatgggcca aatggagagt agatgccatc 31440 taatcagctc cagctgatgg ctgccatatg aaaataaaga tctagtgttg ccagaatttt 31500 gggcaagagt tgtcagaaat ccacacttta tgtggatttt cccatttaaa aaaattgaat 31560 cagttcaaat tttaactcag agcatgcggg ccaactcaga gttaaagcat atccgagttt 31620 gagacttgga ttgagatgct caaccaaagc tcctcaatta gacagccagg ctatattctt 31680 tccactgttc tgaagtccag tgctatgctg ggtataggtg acataaagat gaataagtgt 31740 tcaaactatc cccagagaac taggataaac ttgaactcaa gcaaactggt gtgtgataaa 31800 tgctttaaaa ggaatgtgga aaaaaaaaaa aaaaaagaaa tgtacggaga aagaaatgaa 31860 tgacaaatgc ctgggaggtg ggggaagtct tcacactgga attgatggtt tccctgggct 31920 gtgaatgaat gtagagtgct agagtagatc tgtggttaat tactgagtac catggaggca 31980 tttgaccaga agttgctgtg cagaaggacc tacaggagca aagacaaaga tacatgaaag 32040 aaggttggca tgttagagta acagtgaggg ataccatgtt tggcaggaga tgaagtcatt 32100 tgcagtctaa gggtctttag ggaccattgt gaggtgtttg gaccttgtcc tttatgggta 32160 ggaccttgct aagcaatgag aggaatacaa aaaaaaaaaa aaaaaaaaaa aaccacagtt 32220 gcccgtaaac acccttcagg aagaccatct caggtggcta gcacaaggtg tggcccatag 32280 caggcattaa ataattattg aatgagtgag ttatcaagta ctaaccatgt gattcaggga 32340 aataggtgct gcgggaactc agaagagaaa aatcactgcg agctagagac gtaagagtga 32400 aagggaggct tgagctgggc ccccaaagat ggagagctgt cagaaggtgt attggttttc 32460 tgtttgccac tctagtgaat taccacaagt ttaatggtgc aaagcaacac aaatttatta 32520 tcttagagtt atttaggtta gaagtcaggc acaggtctta gcaggctaaa tcaagatgtc 32580 tgcagggctg tatttctttc tggagtccct gggtaagaat ccatttcccg ccgggtgcag 32640 tggctgatgc ctgtaatccc agcactttgg gaggccaagg tgggcagatc acttgaggtc 32700 agcagttcaa gaccatcctg gccaacatgg tgaaaccccg tctctactaa aaatacaaaa 32760 attagctagg cgaggtggca catgcccgta atcccagcta ctcaggaggc tgaggcagca 32820 gaattgcagc cgggaggtgg aggttgcagt gagccaagat cgtgccattg cactccagcc 32880 tcggcaacag agcgagactc catctcaaaa aaaaaaaaaa aaaaaaaaaa agaatccttt 32940 tcctttcctt ttccacctcc tagaggctgc ccaacacacc ttgggtcatg gcccccttcc 33000 tccatcttca aagccagcag tagcaggttg agtcatcaca tcactctgac cttgcttctg 33060 tcatcacgtc tctgactccc tcttctgcct ccctcttcca cttttaagga tccttgtgat 33120 tatattgggc ccacccagat aatcccagat aatttcccta ttttgaagtc agctgatagc 33180 caccttaatt ctatctgcaa ccttaattct cctttgccat gtaacctaac gtattcacag 33240 agtctaggat taggacaagg acatcttcaa gggaccattc tgcctgccac aagaagatta 33300 ataacctgga ggtaaaaatg gtgtgagtca gtacagacgt aaacatgacg tgcttctatt 33360 agaaaacagt gatgggctgg gcacggtggc tcacacttgt aatcctaata ctttgggagg 33420 ctaagacagg gagattgctt gaaatgaaga gtttgagacc agcccagact ataatcctgg 33480 gcaacaaaat gagatccccg tctccacaaa acaaaattta aaattagggg ccaggttgtg 33540 gcagctcaca cgtataattc cagcactttg gtaggctgag gcaggcagat ggcttgaggc 33600 caggcattct agaccagcct gggcaacatg ccaaaacctc atctgtacaa aaaatacaaa 33660 aagtagccag gcatagtggt gtgtgcctgt agtaccagct actctggagg ctgcggcagg 33720 aggattgctt gatcccagga gtcagaggtt gcagtgagct atgatcgcac cactgcacac 33780 tacattttag cctgggcaac aacagagtaa gatcctgtct ctaaaaaaaa aaaaaaaagc 33840 aagcagtgat gtatgtttgc acgcacatac aaaagccatg aggagacctg cttagctaga 33900 aggaaggatt tatgctggag cagcaggaaa ggaaattgga gggttgataa gcaggttggt 33960 gggttgggat ttgttttgtt tgttttagga gacaaggtct cgctctattg cccaggctag 34020 agtacagtgg gagggtcata gtttactgta accttgaaat cctggcctca agtaatctta 34080 ctacctcagc ctcctaagta gctaggacta caggtatgca cccccatgcc aggctaattt 34140 ttttttttca attttttgtg tagagacagg gtcttgccat gttgcccagg ctggtcttga 34200 actcctaggc tcaagctgtc ctcctgcctc agcctcccaa agtgttggga ttacagatat 34260 gaaccaccat gctggacctg tttttgtttt tgaaggtgaa caattttaaa agtgtttttg 34320 ggccaggcac aattcaatca cttgaaccca ggaggcggag gttgcagtga gtcaagatca 34380 tgccactaca ctccagcctg ggcgacacag cgagactctg tctcaaaata aataaataaa 34440 aagtgttttt gtgtttgagt ggttaacata attaaaaata ttttcaaaaa gtacagaagg 34500 gactaaaagg gtcacctcca ctgcattagc ttttggtttt ttttggtttt tttttttttt 34560 gagagatgga gtttcgctct gtcgccaggc tggagtgcag tggcgcgatc ttggctcccc 34620 gcaacctttg actccctggt tcaagcgatt ctcctgcctc agcctcccaa gtagctgaga 34680 ttacaggcac gcaccacccc acccagctaa tttttgtatt tttagtagag acagggtttc 34740 accatgtttg cgaggaaggt ctcaatctcc tgacccggtg atccacccgc ctcagcctcc 34800 cctgctggga ttacagatgt gagccaccgt gcccagtctg cattatcttt tttatctatt 34860 tatttatttc atttttattt atttacttac ttacttactt attttgagat ggagtcttgc 34920 tctgtcaccc aggctggagt gcagtggtgc aatcttggct cactgcaacc tctgcctccc 34980 gggttcaagt gattctcctg tctcagcctc ccaaggagct gagactacag gcatgcacca 35040 ccacgcctgg ctaattgttg tatttttagt agagacaggg ttttgccatg ttggctaggc 35100 tggtgttgaa ctcctgacct caagttatac acccatctca gccttccaaa gggctgcgat 35160 tacagctgtg aggtgccacg cccagcctat gtatttattt atttttattt ttgtagaggt 35220 gaggtctcac tatgttgccc aaactgatat tgaactccta ggctcaagtg atcctccctc 35280 ctcggccttg gaaagtgcta ggattacagg catgagccac tgtgcctggc ccactgcatt 35340 attatataga ggcaatcagc gttaccttcc tgagagatac tgaggctgaa caaacatgtc 35400 ttgtatatgc atttgcatct ttttgttgtt ttaacacaag tggcagcatg ctatttagac 35460 atagccttct gtacctgctg tacctggctc ttctcactta ccaatatatc ttggaaatta 35520 tgccaccgta tgggcaattt gatttgactt tcattgattt ccttgttttt ttttttgttt 35580 gtttgtttgt ttttttgttt gttttttgca gttgttaact aaaaagttac tccatgctgg 35640 tgtctggaga tacgttgttg aaaaatataa attgaatctc tgctcttgtg gagacaaata 35700 ctaatctata atcacagaaa taataatttc cttaaagtgg tagtagagct ccaaaggaaa 35760 aacccagggt gccctgtgga ggggtgatgg tgacacttat tctgattgtc aggaacaggg 35820 tgggggtgct ggttgacacc ctaaaccaat gcaggctctt gctcagaaaa aactgtcagc 35880 cctgagattt tgcagatact ttacaaagca cattcacctt tattacctga cctggttctc 35940 tgaataacct tgtcagaggc aaattttgct gttcccacta aattagttaa tacatgtaaa 36000 gtgcttacag cagtgccttg tagatggaaa atagtccaca aatattgtat tgttttacag 36060 atggggagac agagccagga gaagtcaaac attaagagac aaatagttta gggccaggcg 36120 cagtggctca tgcctgtaat cccagcactt tgggagacca gggcagacag atcacctgag 36180 gtcaggagtt cgagaccagc caggccaaca tggtgaaacc ctttctctac taaaaataaa 36240 aaaattagcc aggcatggtg gtacgtgcct gtaatcccag ctactcagga ggctgaggca 36300 ggagaatcac tttaacccag gaagaggagg ctgcagtgag ctgagatggc accactgcac 36360 tccagcctga gcagcagagc gagactctgt ctcaaaacaa cagcataaat aactgaaaat 36420 tagacccagc ctatttactg acagagctct taattgttgt acttagccac tgggctctaa 36480 tagttttcta atgtcacttg tccatttttc cctcaacaaa cttgtggtaa gaggctaagt 36540 gtttaccatg ggccaggagt acaaagatga gctggagtac aaagatgagg aaattgtagg 36600 ctccacccct gaggacaata gcggactgag atagcttagg aggcggtgaa ttcatgagca 36660 gcacaggtct ttagcagaaa caagttgact gctggttgtg atgttataaa ggacattctt 36720 ggatcattta ttgcaaactg gctctgtgca gagctcactg tcttgggctt tttgagtgat 36780 acgtgggtgt cttgggggac tggagggttg gtgggggaaa tgtttttagg aggtaattta 36840 gtacatgttt ctgcagccaa atacacatat tactgggtgg tcaggtgaga tgatattaat 36900 acttatgtga aaatgtagac ataaagttcc ttgataagca aagtaaagca agtgaactaa 36960 tttaaagaaa accatttaca gctggatgtt gctcacgcct ataatcccaa cactttggga 37020 ggtcgaggcg ggcggatcac ttaaagtcgg gagtttgaga ccagcctgcc cgacatggtg 37080 aaaccaactc tactaaaaat acataaatta gccaggcacg gtgatgggca tctataatcc 37140 cagctactca gggggctgag gcaggaggat cccttgaacc cgagaggcgg aggctgcagt 37200 gagctgagat cacgccactg cactccagcc tgggtgacag agtgagactc catctcaaaa 37260 aaatttttga aaataatggt gcagggccgg gcgtggtggc tcacgcctgt aatcccagca 37320 ctttgggagg cccaggtggg tggatcatga ggtcaggaga tcaagaccat cctggctaac 37380 acggagaaac cctgtctcta ctaaaaatac aaaaaattta tccaggcatg tagccggggc 37440 gcagtggctc acacctgtaa tcccagcaat ttgggaggcc gaggcgggcg gatcacttga 37500 ggtcaggagt tcaagaccag cctggccaac atggcgaaac cccatctcta ctaaaaatac 37560 aaagaatagc tgggtgtggt ggcgcacacc tgcaatccca gctacttggg aggctgaggc 37620 aggagaatcg cttgaacctg ggaggcagag gttgcagtga gccaagatca tgtcattgca 37680 ctccagccta ggcaacaaga gcaaaactct gtctcaaaaa aaaaaaaaaa aaaattatcc 37740 aggcctggtg gcgggcgcct gtagtcccag ctactcagaa ggctgaggca ggagaatggc 37800 gtgaacccgg gaggcggagc ttgcagtgag ccaagatcgt gccactgtac tccagcctgg 37860 gtgacagagt gagactccat ttcaaaaaat aaaaagaaaa gaatagtgca aatattatat 37920 gggtggctat ggcagatgta aaggtgattg gcaattcttt ttctggaaaa gctggcccaa 37980 gggttaaaag gaagagctct ggagtgaaag agactgcctt tgcccttgac cttgggtaaa 38040 acttaacctc ttcacatagt ttcatccttt acaaaatgag aagggtgtgg caatgattaa 38100 gaaaaattca gggctgggcg tggtggctca tgcttgtaat cccagcactt tgagaggccg 38160 aggcgggcag atcacgaggt caggagattg agaccatcct agctaacacg gtgaaacccc 38220 atctctacta aaaatacaat tagctgggcg tggtggcagg cgcctgtaat cccagctact 38280 ccggagggtg aggcaggaga attgctggaa cctgggaggc agaggttgca gtgagccgag 38340 atcacgccat tgcacttcag cctggatgac agagtgagac tctgtctcaa aaaaaaaaaa 38400 aaaagaaaaa gaaaaaaaaa attcaggcta gggggcatgc ctgttatccc agcacttggg 38460 aggccaaagt gggaggattg cttgagccca ggagttcaag accagcctgg ccaacatggt 38520 gaaaccgtct ctactaaaaa tacacaaatt agtcgggtgt ggtggtgggc acctataatc 38580 ccagctactc agggggctga ggcaggagga tcatttgaac ccggcagagg ttgcagtgag 38640 ctgagatctc accactgcac tccagtcttg gtgacagagc gagactccat ctcaaaaaat 38700 aaaattgaaa ataatagtgc aaatattata tgggtggcta tggcagatgt aaaggtcatt 38760 gggaattctt tttctacaaa actggcctaa cggttaaaag gaagagctct ggagtaaaaa 38820 agaccccccc ttgcccttga ccttgggcaa aacttaacct cttgacacag tttcatcctt 38880 tacaaaatga gaagggtgtg gggatgatta aggaaattca ggctaggggc agtggctcat 38940 gcctgtaatc ccagcacttg ggagaccaag gtgggaggat tgcttgagcc cagaagttca 39000 agaccggcct gggcaacata gcgagacccc atttctacaa aaaataaatt aactggtcgt 39060 ggtgacatgt tcttgtggtc ccagctactc aggaggctga agccggagga tcacttgagc 39120 ccaggagttt gaagctacag tgagccatgc ttgcaccact gcactcctac ctgagcaaca 39180 gagaccctgt ctcaaaaaaa gagagaaaga agaaaaggaa aggaaaatgc tcgtagcacc 39240 taaaacagtg ctcagtaaat gtttgctgaa gctgtaacta tagtatgtag tagaaagtgg 39300 tagttatttg aaagagagtc aaagatacgt gctctgggaa ttaccactaa atgaccaaaa 39360 gttcacgtca aaaaaataaa atcagatcaa gttagaaatt tttttttttt tttttttttg 39420 agacagaatc tcactcttgt cacccaggct ggagtgcagt gacgctatct ctgctcactg 39480 caacctccgc cttccgagtt caagcaattc tcgtgcctca gcctcctgag tagctgggat 39540 tacaggtgcc cgtcaccacg cccagctaat ttttgtagtt ttagtagaga cagggtttca 39600 ccatgttggg caggctggtc tcgaactcct gacctcaagt gatccaccca cctcagcctc 39660 ccaaagttct gggattacag gtgtgagcca ccgcacctgg ccagaaaaaa ttttattatg 39720 cacacaaaag aacagttgga gattagtcag atgctccagt cactgtagtg agggcagtgt 39780 taataaagcc taaggaagga ttttgacctt ttttgtgatt ggctgttata cattaacaat 39840 ctgtttacag ccagtagagc tgttcaaact gttttgtcta tagttgattc ctttaatttt 39900 actgaattat gctgacaagg atgtaaagct ttgtgttctg tttatgattg attagagcta 39960 catttcaggg aatcaggata tcttaaattc cggctatgtg gctgtgggca gttggccttg 40020 gagtatatct aaactgtggc ctccactttc atttttcttg aaacattgct atcaactggg 40080 aagagtatgt gactttatgc ccagtttccc ctctcagatt tttatgacgg ttgtttttct 40140 ttttgttatg ccatttgagg gattgatgtt tcttaaacta tgaagtactt ggctgtctct 40200 ctccattgct gttcaggtta acagccacca tttgtaaaca ctttgttgga gctcattcct 40260 tctctgctag gaactttaca agaattgtct caatcctacc acacctttgg caggaccctt 40320 gttatcagag ttttcattat ccatgtatcc atagttacaa ggctatatag aaaagcaaaa 40380 gtcatcacac aagaatcttg ctaacaaact acttataaaa ttagtcacta cttaaccatc 40440 cctctgctta tccctgccag tcccattaac atgtttggta gtcaatttct ggctgatgaa 40500 gagatacatt aagcatcaag gtaatgcaaa tgtaaataaa actgactgta gactgaaatg 40560 gcacatctcc caaaacttgt aggactaggc gaaatccctg caagtgatga tagaaaacct 40620 tcagccttat accagttaac aaaggaagaa gggaaatcaa caaagatgat gagatggtaa 40680 aaacttgaaa agtagaggat ttgcctagga aaaattaagc ccttcggaaa cttagtaaag 40740 ctaaggaata ttttggcaaa accatctttt gtatgttgca aaagtgagac aggaaatgaa 40800 gtatagtgtt tgggaatttt ttttttttga gatagagtct tgctctcctg tccaggccgg 40860 agtgcagtgg tgcgaccttg gctcactgca gcctcagcct cctgagtagc tgggattaca 40920 ggcatgcgcc accacacccg gctaattttt gtatttttag tagagacagg gtttcaccat 40980 gttggccagg ctggtcttga actcctgacc tcaggtgatc cactcgcctc ggtctcccaa 41040 agtgttggga ttacaggcat gaaccactgc acctggccta gtgtttggga aaactatact 41100 aggaaaagaa tagttgcttt aagtcattct ttgattattc tgagaattgg catatagctg 41160 ccattataac ctacttttgc taaatataat aataataatc attattttta ttttttgaga 41220 cagggtcttg ttttgtcacc ccggctggag tgaagtggcg caatctcggc tcactgcaac 41280 ctccacctcc gggtgcaagc aattctcctg cctcagcctc ttgagtagct aggattacag 41340 gcacaagcca tcatgcccag ctaatttttg tatttttagt agagacaggg tttcaccatg 41400 ttggtcaggc tggtcttgaa ctcctgacct caggtgatcc acccgcctcg gcctcccaaa 41460 gtgctgggat tacaggcgtc agccactgtg cccggccctg ctaaatataa tattaacttt 41520 ataattttag tctcattttc cacccagatc ttgtttatca ctatctgggt ggtagtgata 41580 aagttccacc cagatcttgt ttatcactat tccctatgaa atgtttctgg gtggccgggc 41640 gcagtggctc atgcctataa tcctagcaat ttgggaggcc aagacaggtg gattgcttga 41700 ggcccggagt tcaaaaccag cctggccaca tggtgaaacc ctgtcactac taaaaataca 41760 aaaaattagc caggcatgat ggtgggcgcc tgtaatccca gctactcggg aggctgaggc 41820 aggagaatca cttgaatctg ggaggcaggg gttgcagtga ggcgagatca tgccacggca 41880 ctccagactg ggcaataaga gcaaaactcc gtctcaaaag aaaaaaaaaa gaaatgtgtc 41940 tgggtatgtt tttggctgca attagctgaa aaccctgact caaaatggct tattgcagat 42000 acttagaagc ccagaggtgg gcctccaaag gtcattgtct cagtggcctg gactctgcat 42060 ttttccactc tgccatgttc aggtctcagc tttgtcctta ggaaggctcc ccatgtggca 42120 caaatgcagg agtcacatcc agaagaagaa gcctttcttg ccgggcgtgg tggctcacac 42180 ctgtaatccc agtgctttgg gaggctgagg tgggtggatc acgaggtcag gagttcaaga 42240 ccagcctggc caacatgatg aaacccccat ctctactaaa actacaaaaa ttaaccaggc 42300 gtggtggcgg gcacctgtaa tcccagctac tcgggaggct aagccaggag aatcgctgga 42360 acccaggagg cggaggttac agtgagtcga gatcttgcca ctgcactcca gactgggcaa 42420 cagggcaaaa ctccgtctca agaaaaaaaa aaaaaaaaag aaaaggccaa gcgtggtggc 42480 tgtaatccta gcactttggg aggctaaggc aggcagatca cgaggtcagg agtttgagac 42540 cagcctgacc aacatggtaa aaccctgtct ctactaaaaa tacaaaaatt agccgggcac 42600 ggtagcatgc ctgtagtccc agctactcgg gaggctgagg caggagaatc gcttgaaccc 42660 gggaggcgga ggttgcagtg agccaagacc gtgccagtgc attccaacct gggtgacaga 42720 gggagactcc gtctcaaaaa aaaaaaagcc ttccttggtt tcctgccaat ttcctgtcat 42780 gtttctttgt cccgaattgg gccaatatcc atgcccattc ctaatacaat taccttaatt 42840 gacttagatt agccctgaag catgtagtga tgtgggggag gaatgacaac tgaagaaaat 42900 agaaaagaag ggacaaaggt tgttgagttg gcaaccaaca attcctgtta tagcttttta 42960 aattaattca ctttaagtgg tactgattat tcatattgtt atttccatgt atagagagag 43020 aagaaattgg aggcttagag gaagtgaagt gacttgtcca aggtcacata gctaagtgga 43080 atttattttt ttttttttta cttttctgag acaaagtctc actctgtcgc ccaggctgga 43140 gtgcagtggc gtgatcttga ctcactgcaa cctctgcctc ctgggttcaa gtgattcttc 43200 tgcctcagcc acccgagtag ctgagattac aggtgtgcac cagcatgccc ggctaatttt 43260 ttgtattttt agtagagatg gagtttctcc atgttggcca ggctggtcat gaactcttgg 43320 cctcaagtga tccacctacc ttggcctccc aaaatgctag gattacaggt gtgagccacg 43380 gcgcccagct actggaagtc atgatgcaag ctgttgtttg aatcatgaat tccaaactta 43440 atgagtgcta ggttgaagtt attttttttc tgtttccctt aatcttctat tgagatataa 43500 catgtattga agcacagaca tcttttgcaa gaattcattg agcactatag ttatattcat 43560 ctgtacttac tgtctccctg gtaaaggcat aaactccctt caagatgggg acatggtttt 43620 atactttcct gaatctcctt tagtgcttat atctaacagc acttaaccag gatctggagg 43680 gggtcaacca gtcttgcttc cttccaatct actctgtaga tgtttgtgtt tttctactgt 43740 aactatagag gtaaaggagc caatggtgtt tccagtgtct ggcacataat aggtgctcta 43800 tgaatgtcaa atgaatgact gaggcataaa aagttcttcc tatgacataa gtagtataat 43860 aggaagatca ctgggataga attttcttag aagacgtggc tcctagtcct agcactatta 43920 ctcttactga ctataacttt ggacaagtca tttgtttaat ttcaaacatt tactgaattc 43980 tgtgtaccaa atactgtaca agttgttcaa aaggctacag agtctctact ctcaaagtct 44040 agtcagggga gagattacac aggagtgaaa ccccatctct actaaaaaaa aaaaaaagaa 44100 agaaaaaaat agccaggcat ggtggcaggc acctgtaatc ccagctcttg ggaggctgag 44160 gcagaagaat tgcttgaacc caggaggcag aggttgcagt gagtcaagat cacactactg 44220 cactccagcc tgggcaacag aacgaatatc tgtctcaaag aaaaaaaaaa aaagaaaaaa 44280 aaagtatgtt tagagatcct taaggaagtt ttgaacctat ccaatatgtt gggagtcaag 44340 atgaggaggg taaaagtagg aattcagaga aaggataaat attttgaagg aaggcagcat 44400 aatggttaac tagtcagact gcagacaaac aagcagtaca aatcccatgt tcccaggtct 44460 tagctggagg attaaatccc agattctcat ccttgagaac ctctttaagc ttgttttccc 44520 atctgtaaaa tgtagatgat aatagaatcc ttttcctact gtaaaatgat gcacattggg 44580 ggcttcatgt agccagatat ataataaatc ctcaatacat gtagcagtgg taggggagaa 44640 ctaaaagact tgttaacata ttggatgtag gtgagaaaga agaatcaaaa agaatatcca 44700 ggttcccgcc ctgggagggg cagacataaa tggagccagg aatggtacaa ggagctttgt 44760 ggtgggcact cactagtacc tttctttgga atagctcaac aaatgttcac taagtacaca 44820 taaagtcaat ataacttgat gagctagagt taggctaaga tgttgagtta gcagaagagt 44880 agtacccaac taagggcttg aggaaggctt cctagaaaag ataatgggtg cacgtagtcc 44940 tgaaggatga gcaaggcttg cgaggaggga aggtaggaag ggcattccag acaaagggac 45000 aaacatgcac aaaggtgaga cagagcatgg tgaacacaca aagttgtagg cattttgtct 45060 ttctaggaca caaaaaacaa ggtgatgaaa acaaggctgg agagacaagc ggagaccaca 45120 agtggtcacc cctcactggc ctcgctgtac tactggactg ctccagccct tcctggccca 45180 gagctagaga tggcaccacc cccgcactgt gcacacaata ggtacagaca ctctcagccc 45240 caaacccctc cagcctgtta ctgtgagact cacacatcct gttttcccaa gcttgcccca 45300 cagggtgagc aaactggacc agctggatta gagtatttgg aaaagtgcag gtggagtttc 45360 taggctatgc cacgtcaggc cagggggtga gatttttttc ccttcccctg gtctttgggc 45420 tggggcactc cctgaggagg gaggggtgtg acccatccca cccattggtg gtccatgatc 45480 cattcatcca gtacatcatc cataagcatc tgctgagccg ggcgcagttg ctcacgcctg 45540 taatcccagc actttgggag gccgaggtgg gcggatcatc tgaggtcagg agttcaagac 45600 cagcctggcc aacatggtga aaccccgtct ctactaaaaa tacaaaattt gccgggcatg 45660 gtggcgcatg cctgtaatcc cagctactcg ggaggctgac acaggagaat cgcttgaact 45720 caggaggcag aggttgcagt gagtcgagat cgagccatcg cactccagcc tgggcaacaa 45780 gagtgaaacg ccatctcaaa aaaaaaagca tctgctgaag gcacagtatt gtgttagagg 45840 cttggactac cctgaggaat aatagtcctg acacttgagg acatccccat ccaattggaa 45900 aggcactgga taaacatcta agaaaatgtc acaaggcata aaagctgtaa taataatagc 45960 taacttgtat ttagggtaaa caaaaggctg aatcaggctt tggactaaat attttgcctg 46020 tggctcattt aatcttaata acaaccataa gattatctca ttttatgatg aggaaactgt 46080 atacagagag gtgattgact tgcctaaggt tgaacagctt atgagtagta gagccagtat 46140 tcaaatccag tcagcctcca gtgtcccctc tctttagtca ttagatatag tgctacccag 46200 agaatctgct aagccttata gataaatgct atgaattcag aggcaggagc aattactgtg 46260 gcttgggggc atccacaaag actttctaag gtggtgacac ctgatttggg ccttgaaact 46320 ggttgaatag agataagaaa agaacagata atcaatttaa ctgccgttgt gttttgaatc 46380 atcactttaa gcctagaatg acaaagctgg aaaagaccct aaatatcatc tagcccagtg 46440 gttatcaaat tttcttagga tgtggacatt tttctttaaa tgaaacatga gtagaagcca 46500 gatgcagtgg ctcatgcctg taatcccaac tacttgggag gctaaggtga gaggattgct 46560 caagcccaga agttggacac caacctgggc aacggtgaga ccttgtctca aaaaagaaag 46620 aaagaggccg agggcggtgg ctcacgcctg taatctcagc actttgggag gctgacgcgg 46680 gtggatcact tgaggtcagg ggttcgagac cagcctggcc gacatggtga aaccctgact 46740 ctactgaaaa tacaaaaatt agtcaggtgc agtgctgcat gcctgtcatc ccagctactc 46800 gagaggctga ggcaggagaa tcgcttgaac cccagaggtg gaggttgcag tgagctgaga 46860 ttacaccact acactccagc ctgggtgaca gagtgagact ttaatttcaa aaagaaagat 46920 gagcagtaat cttgtctctt aaaaaggagg accaaacatt ccctagcccc aaaacattcc 46980 ctgaaaagtt cagttgagaa ccactgatct agtccaatgt cctgggatcc tcgcttttat 47040 ctttgctatc tggagaagga agagacagcg gtagttccca aaagacacaa acaatgggga 47100 cattttaaac gggagtaacc agctaagcac tctgctgctg ctgcttgtct atttgccctc 47160 ttgtcctgcc tcagggtgaa ttgttggcag ctacaaatgg caaccaagag agaatggagt 47220 tggggcttag aagtgcggta gaggaatatg aagggggctg gagttggaga ggctcttaaa 47280 gaaagagctg actatattgg gactggagag ttaatgtaaa tctcttcttg gttcatgggg 47340 attttgttgt tattgttttt ttccccatga cacaactctc aggagatcct gagaacacgt 47400 gccctgattt ggggggggtt ttaattttaa cttttttttt tttttttttt ttttgacaga 47460 gtctcactct gtcacccagg ctggagtgcg gtggcgccat cttggctcac tgcaagcaag 47520 ctccgcctcc cgggttcacg ccattctcct gcctcagcct cccaagtagc tgggactaca 47580 ggcgcctgcc accacaccca gctaattttt tgtattttta gtagagacgg ggtttcacta 47640 tgttagccag aatggtctcg atctcctgat ctcgtgattc acccgcctcg gcctcccaaa 47700 gtggtgggat tacaggcgtg agccactgta cctggccaaa attttttttt aattagagac 47760 agtctcttgc tgtgttgccc aggctgatct caagcagtcc tcccaccttg gcctcccaaa 47820 gtgctgggat tacaggcgta agctatagca cccagccttc cttctttcct taattctatt 47880 tttttttttg tttgtttgtt tatttgtttg cttttgagat ggggtcttgc actgttgcct 47940 gggctggagt acaatagcgt gatctcggct ccctgcaacc tctgcctccc aggttcaagg 48000 gattctcctg cctcagcctc ccgagtagct gggattacag gtgcctgcca ccatgcctgg 48060 ctaatttttt gtatttttaa cagagacagg gtttcactat gttggccagg ctagtctcaa 48120 actcctgacc ttgtgatctg ccctccttgg cctcccaaag tgcggggatt acaggcatga 48180 gccaccatgc ccagccttcc ttaattctat taatatatga atccttttct tttttttaaa 48240 aaaaagagat agactcttga tctgttgctt aggctggagt gcagtggcac aaatcagagc 48300 taactgcagc ctcaaactcc tgagttcaag caatcctcca gcctcagcct cccgagtagt 48360 tgggaccaca gttgggaacc actacacttg gccctactac gggtttttcc tgtttgtttg 48420 ttttttgttt ttttgttttt ttgttttttt gttttgagac ggaagtttgc tctcgttgcc 48480 caggctggag tgcaatggcg cgatctcagc tcactgcagc ctccgcctcc cgggttcaag 48540 cgattctcct gcctcagcct cccgagtagc tgggactaca ggcatgcact accatgcccg 48600 gctaattttg tatttttagt agagtcgggg tttctccatg ttggtagtca ggctggtctt 48660 caactcctga cctctggtga tccgcccatc tcggtctccc aaagtgctgg gattacaggt 48720 gtgagccacc gcgcccagct gtttgttttt ttgagatagg gtctcactct gttgcccagg 48780 ctggagtgca gtggcatgaa catggcttac tgcagcctta acttcccagg ctcaagcgat 48840 cctcccttct ctgcctcctg aatagctggg accacaggaa tacaccacca cacctggctg 48900 atttttaaat tttttgtaga gccagggtct ctccatgttg cccaggctgg tctcagactc 48960 ctgggctcaa gtgatcctcc cacctcagcc tcccaaagtg ctggggttat aggcatgagc 49020 cactgtaccc agcccccttc agggtcttat ctttataagg ggtggggggt ggtcagcacc 49080 tttctcattg ttacctctac cttccctagg tatgtgcagg tgaaatttgt ctgcattcgg 49140 acccaatcaa acaggaagag aacgcgggag gcagacatgt gcccagcgta cttgctccta 49200 aggtacaacg agagactaga tagactattt atcagtgaac taaacacaca gcacatacat 49260 ggtgactcta aagtggctag tcctggagga gacaccactg gcaaatctca aaagacaatg 49320 tgcctgcaga gactccagcc tgtgcagccc acaaccaaaa aagaccttga cactgccgag 49380 aagtccctgg ttgagccatc gttttgccta gataaggtac aagtgtcctc aaagccagag 49440 caggaaggca tcactccttc tgacctggcc aagatagcaa aagtgatgaa gaactttctt 49500 aaggtagatg agggttccat ggcttccttc agtgtgggtg acagccagca cctggaccgg 49560 ctcagcttcc agagcagtaa gatgaccgac ctgttcatcc gcttcccaga gaatctcttg 49620 ctacaccggg tggagaacac ccagggccac atcctctatg ctttcttggt ggagaacaag 49680 gaacgagaaa gtcgagtggt gcactttgct gtgctcaagg cggagacagt cacctctgtg 49740 gccaagatgc tgagcatctt cacagagttc aactccgatt ggcccaaggt caaggtggtc 49800 tttgtggacc cttcattcca ttaccgggct atcctgcagg agatctttcc tgctgcccgc 49860 atcctccttt ccatctacca cacaacccga ctcttggaga agaagttgca tcgtagttca 49920 gcaaatccat cctttaaaag gctcatgaag gaagccctgc gggaggccgt gtttgtcact 49980 tctgaagcca gcctgaaaaa tctctgccag atgtcccagg ccgtactgga tgaggatctc 50040 ttcaacttcc tgcaggccca ctggttcacc tgtgaactgc tgtggtacat gcatgttagg 50100 aagggcctgc ttgcgtgtaa cacctacatg gacagcctag acattgtcac cagcaaggtg 50160 tcaagcctct ttcgggaaca gcagtcgctg ctggactgca tcctctgctt tgtggattac 50220 atagacttct ttaataccaa aggcttgaag aacttgccca cacctcctcc caaattaaag 50280 agagctcggc cggcaagcat gccactgaag tccaagaagg cttttggaat ctgtggagag 50340 agccttacca gcctccctgc agaagagacc aagccagacg cacagcaggt acaggtacag 50400 cagcagtcac aagtgccgcc ctcgcaggtt ggcatgctgg acaccttgca ccagagtggc 50460 tctgaactag cctacaagct gtgccacaat gagtgggagg tggtacagaa ctccacccac 50520 ctggtggaca tggctggctc ttcagtggac gttcagctgc tagaggactc tcaccaggtt 50580 agcaaagatg gctgtagctg cagctgttcc tttcaacaat ggtaccacct gccatgccga 50640 cacattttgg ctctgctgca caccagccag cagccggttg gtgaagccat ggtgtgccgc 50700 cggtggcaga agaagtacca gtacctcctt gggcccaatg gggagctcca ggatcgtggt 50760 atggtcccaa acacaggcca gcctgagaag caaggacgga acgacatgat tcaggaccta 50820 agcagggagt tagcaaacct gctcatgcag accgaggggc cagagctgga ggaacgctac 50880 tccaccctgc gcaagattgt ggatatctgg gctggcccct cccagccatc tgagctcttt 50940 cagcagccag gagactttaa ggacgtgggc cgcctccctt tcctctgggg aaagcaagaa 51000 gaaggggagg gattccctcc tgctacagct gtgatgcatt attgaagcac tttagctgaa 51060 gcattggacc acaaacactt ctccttggaa gtgtgagagt ttaaagtggg caggacatac 51120 tagggtttag cattttagcc aatgtcttcc taggtggggc taggaatatt gttacagtag 51180 agaggaaggg aactccactg tgtgacagtc ctttcaatct gccccttttc agccctactt 51240 ttggcattcc ttgggagcct cagttgttgt tcaaggccaa agttatctcc gtgctgcaag 51300 gtcaccctct tcctccccca gcccctgaga tcagatctta tttgctctgc aaagatgaat 51360 ccctgcctca ggttagggtg agacaaaatc ggtctggtaa aagggcctgt tttcagggac 51420 aaagggaatg aggatgatct ttggctgttg ctgctcttta tgaagaatct tatttgtaac 51480 tttttattca tattaaagtt gtttttaata aaattaaaca agggaaatgt gttctgcttg 51540 atcagggaag gaagaggaat tgcatagcaa taggactcga ctttacagtt aggaagtggc 51600 tgctctaggt ggatttatta attttaaaga aaattgaggc caggcgcagt ggctcacact 51660 cataatccca gcactttggg atgtcgaggc gggtggatgg atcatctgag gtcaggagtt 51720 cgagaccagc ctggccaaca tggcgaaacc ctgttctact aaaaatacaa acattagcca 51780 ggcgtggtgg cgcacctgta atcccagctt cttgggaggc tgaggcagga gaatcgcttg 51840 aacccaggag gcggaggttg cagtgagcct agatcgtgcc accgcactcc agcctgggtg 51900 acagagtgag actctatctc aagcaaaaaa caacaacaaa aaaaaaagaa aagaaaatta 51960 agtattagca acctaatggg gttgtggagc caaatagaac ctgatgcctc acattcaagg 52020 atttggcaat ctgcgtctta atttgcctcc ttcctacaac taagccttca aggttgattt 52080 caggtttcct tatattctag cgggaagagg ccaaatagac tggagggtgt gggggaaaaa 52140 cctgaatctt agacttgact gccagcaact tgctggggaa ctgtgggcaa tttctttgac 52200 ctcagtttcc tctgtaaaaa ttagcatgtt ggcctgttct aatcccagat ttcccctcta 52260 ggtttacata agcacctttt tgttttttgt tttgagatgg agtttcgctc ttgttgcttg 52320 ttgcccaggc tagagtgcaa tggcagaatc tcggctcact gcaacctctg cctactgggt 52380 tcaagcgatt ctgcctcagc ctcttgagta gctgggatta taagcatgtg ccaccacgcc 52440 tgcctaattt tttgtattta gagatggggt ttcaccatgt tggtcgggct ggtcttgaac 52500 tcccgatctc aggcaatcca cctgcctcag cctctcaaag tgctgggatt aaagggatga 52560 cctactgcac ccagcccaat aacattttcg atgcgtaagt accaacactg atttgatgtt 52620 gctagttggt aatcttaatc ctccaaggcc tggtaaacac ccagttttct aagtctgcca 52680 tcttcaaggg aactgaggac aagagaccag ttagtaggcc cttgcactac tgtagtagga 52740 ccctaaataa gtcatggcat cattctgtag aatactggag ggggttgggc tagagaatgc 52800 caagttttgg cttgtttaag gggatctgga tttcctcagc tctaaaagtt gggctcctga 52860 tccccgaagg aggagtagaa tttgagacct ggaactcagt ttccccataa ggtagaatat 52920 gcgttatgac tatatatgca ctgtttccta aattccaggg gctttagagt ttcacacaca 52980 cacacacaac aaaacaaaac ccgcggtggc tcacgcctgt aatcccagca ctttgggagg 53040 ctgaggtggg cgaatcacga ggccaggagt tcgagaccag cctggccaac agggtgaaac 53100 cccgtctcta ctaaaaatac aaaaaattaa ctgggcgtgg tggcgggtgc ctgtaatccc 53160 agctactcag gaggctgagg caggagaatc atcgcttgaa cctgggaggc ggaggttgct 53220 gtgagtcgag atcttgccac tgcactccat cccaggcgac agtgcgagac tccatctcaa 53280 aaaaagaaaa agaaaaaata tatatataac tgctatttat tttccttttc attttctgct 53340 tttgagggag tttccatagt aacgtgtcct tccagtcgcc tagcctgaag ggaagccccg 53400 gagctccagc ttcaaggctc agctctccca gatgcaagta tctttacctc cagccagctc 53460 cttgtaaccc tggcaacacg gcccgcccgc gaatcgtcac gctacgattg gtccgtggtg 53520 ctaaagcctg aaagcgaatt cctcagacat tggtccgagt cactgcgatg ctgacgctgt 53580 ggttggtgag tttggatgtc agtcagagtc ggaggcaggg tcaaataggg agaaatggcg 53640 acggagcctg gctgtgggtg agtgcttcct gaaggggtga aagtgtgaga cagcggatca 53700 ccgcagttag ccgtcacaca gctcccaaag ggatgggagg gaggttttct tctcatccgg 53760 ctccagctgg actctgggaa tgtcagacat ccacatctcc cacccaggtt agaggtgaga 53820 ggtcaaaggc cgtattccct ctgttggttt ttggacccca ggtactgtgg acagcagtca 53880 ggatcccgaa ccaaagactc aactttcagc tacttacaga gtaatggtgg gcaagtcact 53940 tagcttcttt gagccttagt ttatcatctg taaaatgagg acagtaactc ggtctggggc 54000 caaatagagg aaacaatgga atagagtatt gctgctaaaa gagggatata gtagaggcag 54060 gagaagctat gcacatttgt tagccatatt ttatggtgga agggattgag gctcagagag 54120 ggtcattgac ttgcccaaga taacacagca agtttggagc aattgcagtt ctcttataca 54180 taccaggacc aaaggaaaga atggatgcca atcagtcatt tataaatata aaatcgtatt 54240 tttattttat tttatttttt gagacagagt ttcactctgt cacccagagc tggagtgcag 54300 tggcgcaatc tcggctcact gcaacctcag cctcctgggt tcaagcaggt ctcctgcctc 54360 agcctcccga gtagctgaga ctacaggcat gggccaccat acccggctaa ttctttttgt 54420 atttttagta gagacgggtt ttcaccatgt tggccaggct ggtctcgaac tcccaacctc 54480 aagttatctg cccaccttgg cctcccaaag tactgggatt acaggtgtga gccactgcac 54540 ctggctagaa tgctattttt ttaaaaggcc atatgcagct ctggccatac ctatttaaat 54600 cccctggaac catatctttc catagctaac ttcttatcat ttagatttca gctccaatgt 54660 catccttctc ccctgagagg ccttccatta ccactttaac taaagtatcc ctcccttccc 54720 cagcttactc tctgacatgt tactcaggtt tatggtcttt gtaagcttca ttattggata 54780 tatatttgct tatttgttta catgtttatt gtgtatcttc ccctagaaca gtgctgacat 54840 atagtaagtg ttcaacaaat attgtgtgga tgaataattg aagagccagg tccctgctgt 54900 ctccttaaac ctctgttact ctccataggc ccatctttgg aaaaaagatc tgggaatgat 54960 tgtctagcct ccagcctcaa cttacttgat gcttgagaga ctcaaagccc cgtggtcagc 55020 tgccctgcaa agaaagtatt ttgaccttgg catttggaca gctcccatct ctcccatggc 55080 cctgacaatg ctgaatgggc tcctgattaa ggactcaagc ccacctatgc tgctgcacca 55140 ggttaacaag actgcccagt tagatacctt caactaccag agctgcttta tgcaaagtgt 55200 ctttgaccat ttccctgaga tcttatttat ccaccggacc tataacccaa ggggtaaggt 55260 cttatatacc ttcctggtgg atggacctcg ggtgcagctg gagggtcatc ttgcccgagc 55320 agtctacttt gccatccctg ccaaggagga cactgaaggc ctggcccaga tgttccaagt 55380 attcaagaag tttaatccag catgggagag agtctgtacc atcctggtgg atcctcattt 55440 ccttccactg cctatcctag ctatggagtt ccccacagct gaggtccttc tctcagcctt 55500 ccacatttgt aagttcctcc aggccaagtt ctatcagctg tcccttgaac ggcccgtgga 55560 aaggctgctc ctgacctccc tgcagagcac aatgtgctca gccacagcag gcaacctgag 55620 aaagttgtat acactcctga gcaactgcat ccctccagcc aagctgcccg agcttcactc 55680 acactggctg ctcaacgacc gcatctggct ggctcaccgc tggagaagcc gagctgagag 55740 cagccactac ttccagagcc tcgaggtcac cacccacatc ctcagccagt tctttggtac 55800 caccccatct gagaaacaag gtatggcttc tctgttccgt tacatgcagc agaactctgc 55860 agacaaggca aacttcaacc agggcctgtg tgcccagaac aatcatgctc cctcagacac 55920 catccccgaa agccccaaac tggagcagct ggtagaatcc cacatccagc actccctcaa 55980 tgccatctgc acagggccag cagcccaact gtgcctgggc gagcttgctg tggtccagaa 56040 atccacacac ctcattggct ctggctcaga aaagatgaac atacagatcc tggaagatac 56100 ccataaggtg cagccccagc cccctgccag ctgcagctgc tactttaacc aggccttcca 56160 cctgccctgc cgccacatcc tagccatgct cagtgcccgc cgccaggtgc tccagcccga 56220 catgctgccg gctcagtgga cggcaggctg tgctaccagt ctagacagca tcctgggcag 56280 caagtggagt gagaccctgg ataagcacct ggcagtgact cacctcaccg aggaggtggg 56340 tcagctgttg cagcactgca ccaaggagga gtttgagcgg aggtatagca ccctgcggga 56400 actggccgac agctggattg ggccttatga gcaggtccaa ctctgattat tctcgatgcc 56460 cagagatgct catgcacctg tgcacactca catccaccca tacacacaca cacacacaca 56520 cacacacaca cacacacact cccttacact gttgtacttc cgtgggccct ccttccagaa 56580 caaggacaac aaggacaagg ttgaagggtc ttctcatcta ccatggcctg ctacctagca 56640 tgtgtctagc tcaatgagac aggagtcagc aaatcttaat ctgtttagtt tactcaggtg 56700 gccacataca gtctctgttg tatattcttg gttttgtttt aatatttttt ttcttttttt 56760 tttttttttt ttttttgaga aggagtctgt ctccgtcacc caggctggag tgcagtggcg 56820 caatctctgc tcactgcaag ctccacctcc tgggttcaca ccattctcct gcctcagcct 56880 cccgagtatc tgggactaca ggcgcccgcc acaatgccgg gctaattttt tgtattttta 56940 gtagagacgg ggtttcaccg tgttagccag gatggtctcg atctcctgac ttcgtgatct 57000 gcccgcctcg gcctcccaaa gtgctgggat tacaggcgtg agccatcgca cccggcctgt 57060 tttaacattt tcataaggta aaaacctttc ttagctcaaa ggtctttaaa aaagcaggca 57120 atccagctgg gcatggtggc tcacgcctgt aatcccagca ttttgggagg ctgaggtgga 57180 cagatgactt gaggtcagga gttcaagacc agcctggcca acatagtgaa accctgtctc 57240 tactaaaaat acacaaatta gccaggtgtg gtggcggggg ccctgtaatc ccagctactc 57300 gggaggctga ggcaggagaa tcgcttgaac ctgggaggca gaggttgcag taggccaaga 57360 tcctgctgcc actgcactcc agcctgggag ggtgagactc catctaaaaa aaataaaata 57420 aatggcaacc cctggtctaa gataagagat aaaacatcag gtggtgaggt tgaggtttgg 57480 ggcttggtag cagttgcccc agtcatgaga tgactcactt aacccgtctc ctttaagtga 57540 gctgggctgg gaggcttcct acaggggaag aggcccctct ggggagctga ctcagccagg 57600 ctccctgaac ttttttcctt gtcccatcct ggggtcaata aaactgaatg ttgcatattc 57660 tagcacttgt ctagtttttt ttttgttcca tagaaggcag tttagggtat atcatggaga 57720 gaatagactt tagagtgtta tacaacatgt gaatcctggt tggttccttc cctgcttgat 57780 ttttgtgcct ggttctgcct tttactagct atgagactta ttaggataag ttacccctct 57840 aaacctcaac ctgattatct gtaaaaatgg ggatctccac agggtatgtt cacagagcag 57900 gcatacctag tgggtgctca attaagtatt aattttcctt ccttgcctat ggtcctatga 57960 cctgccttca acatgctggg aaatttaagg caagaggaga attcaaatac ctaggactta 58020 atataagaaa ttctggccag gcatggtggc tcacacctgt aatcccagca ctttgggagg 58080 ccgaggcagg cggatcacct gaggtcggga gtttgagacc agcctgacca acatggtgaa 58140 accgtgtctc tactaaaaat acaaaaatta gccgggcgta gtggcaggca cctgtaatcc 58200 cagctattcg ggaagctgag gcaggagaat cacttgaacc tgggagacgg aggttgcagt 58260 gagccaagat catgccattg cactccagcc taggtgacag agcaagactc tgtctaaaag 58320 ataaaaatta aaaaaaaaaa attctgggta ggccaggtac ggcgtctcac gcctctaatc 58380 ccaacacctt gggaggccaa aacaggcaga ttggagcagc ctgggcaaca tggcaaaacc 58440 ccttctgtac aaaaaataca aaaattagct ggatgtagca cgtgcctgta gtcccagcta 58500 ctcaggaagg ctgaggtagg aagatcactt gagcccagga ggttgaggct gcagtgagct 58560 gtgattgtgc cactgcactc cagcattggt gacacagtga gaccctatct caaaaaaaaa 58620 aaaaattctg atcaagtctt caaaacaaca taaaagcagc cttaactctc caagcagggg 58680 cccctacctc agataatttc cattgtatct acctgacaaa acctatctcc tgtcttagtg 58740 gtatctggag aaactttagg gtctggaagt ccctgatgaa ggactggaat ttgtcagaat 58800 ggctcaacca ccagctctat ccccatccct gccataggcc ctcctcccaa ccctgtctgc 58860 ccaagaacca tacggagaaa ccaccctaca tatctggtgc tatttcatcc atctacaagc 58920 aggagccagg aggctggccc cttttagatc tcactagggg catcttccca gaggctgtgt 58980 gggcatgtgc ctgctcccac cgcgccccct ccacagcacc ctctggctcc ggatgggcca 59040 tcatgaaagc ttgagcggcc cagatcaggt cctcttcccg aactcctggg acgggcacgg 59100 tggggatgcc agcgatcatc atggcgaggg tgaggatgca gatatcaggc tgggagctgg 59160 cctccttccc cactgcctca gagggtaccg gtagaacccg tggtgacagc ccacacagca 59220 tcaggggcct aggcctgctg gggccaccca ggtcaggggc tctgcttctg gagtagccat 59280 tgtcccagcc caagctctcc agctgcctca catgcgggaa tttgtggcag tttcggctgt 59340 attccttccg tagtgtctcc cagctagtcc ccccagggca gcccctggct tgtggcattg 59400 ccagggctgg gccccaggcc tgggcagcag gtgccacctg ctcagctttc tggctcagtg 59460 ggcctgttcc accagaggcc accaccactg gctctacagg actacagagg ccaagggaca 59520 agcctggaga agcagcccca cctgcagaga caggaatgaa atggaacgtt attctcagtt 59580 ctttgaggag ggggccctga ggggcagggc atgggagcag agcttggggg cgtaactaag 59640 accagcccca gcggactgtc tagaggttgg gaactaggtg ttactcatat ccacactccc 59700 agtccccaac acggagtagg tgatggagaa gcgtttgttg aattaatgaa tagtgagcaa 59760 gcgggtagtt attgattggc aaggatgttt ggaatggctt ttcttctaaa agaattgatt 59820 ctagggccag cccccaaatg cccagcagaa ccgccacctc cccagagcca gaaagcaact 59880 tctcagggga agctgccgca ctccctccaa ttgcaggtgc cccccgctca ccttggccgg 59940 aaggcagagg acctggatga gtttgtggag tcctgaagta ggacatggct tccccaaagc 60000 cccggtttgt gagggaatag tgatctgccg cctgtcctcc cttcttcacc cttctagaat 60060 gtcacctcat agaccctccc cttcacactt ggaatccact ttacagcgtt gacctattca 60120 ttctagaacc tggacatgac aataggatga ggttaaaaga gcaccagacc aggagctggg 60180 tgttctaggt tcttgcccta accttgaacg agtcacccag atagttttgt tccttgatat 60240 ccttatctgt aaagtgtgtc tgatgactgc ccactacctc attaggagtt ttgaggatga 60300 aatgagatca tttgtatgga agcagatgac cagagatgga aacacaggag ccaagtgctt 60360 cgtgccttgt agagtaagac ttcgggtcag acccagtatt ggtatttttc tttttctttt 60420 tttgagacag agtctcactt tgtcgccatg actggaaggc tggagtgcag gagcaagacc 60480 tcagctcact gcaacctctg cctcctgggt tcatgcaatt ctcctgcctc agcctcccga 60540 gtagctggga ctacaggaac ctgccaccac acctggctaa cttttgtatt tttagtagag 60600 acagggtttc accatgttgg ccaggctggt ctcaaactcc tgacctcaag tgatctgccc 60660 acctcggcct cccaaagtgc tgggattaca ggccaggtat tggtattttt caaaattcct 60720 caagtgatta taatatatga caaagttgga accttttttc tagggacata cttctcaacc 60780 ctggctgtac atgagaatct cttgagaagc ttttacaaaa cacaatgtct aggcctaatt 60840 tcccaacaaa tcaaatacga atccctaggg atgggatgtg ggacaccagc actctttaca 60900 tatcctaaga tgactctaac aagcagccag cctagggacc cctgctcttt tgctccgacc 60960 tgctgacctg cagtgattct aaacgaagtg actctcatag gctgtagggg caaggagacc 61020 ttccagtgat caagatgtca gcatcggctg tttatttctg gtcttggctg gcagcaatgt 61080 ggccaacttc ggaccagcca gccacaggtc tggggctcca ggatgcagct gtgctctggt 61140 gcactgtggg tcttcactca tacttgcaga aatccttaag ttctttgggc aggtggagcc 61200 catcaatggc cagccggtgc accatgctcc tttgtatcac taggcggcac agagtctgca 61260 gggatggcac tgtgggaaga agactgtgaa aggcaaactg aactggaggg tgggtctgag 61320 gccaagatcc agaaggtcta ggtcatggtc cccactttgt cattaaatgt gggcaagtcc 61380 ttactgctct ctgggcccag cctgcttcat ggggctgaga gaagcacctc ttcctgagag 61440 ctgccacaaa gctgcagccc tgtttatatc ataacactta gcacaatccc ttccccattc 61500 acttagcagc ttctgggggc aggggtagtg tctgatttgc ctgtgcaact gaagcctcca 61560 gcacaggcct ggcacaaaga gggttctggt gcattgagtt catgaaatgt gatgagaggt 61620 ataactgcaa tgcttaccag ggctataatg aatcatactc agcattaaga agctctcagt 61680 ctggggtttg ttatgcctcg aagccaatag ccaatatgcc caagtctatg agcatgtttc 61740 tttcttttct ttcttttttt ttttttattt aaagagagag ggtcttgctc tgtcacccag 61800 gctgaagtgc agtgctcagt gaactgcagc cttcaattct tgggctcaag cgatcctcct 61860 gccttagcct cccaaatagc tgggactaca ggcatgcacc accatgccca gataattatt 61920 taattttttg tacagatggg gtctcacttt gttgcccagg cttgagctag ctagcttgct 61980 tgcttgcttg ctttctctct cttcctctct ctctctcttt cttttttttt tcagagtctt 62040 gctctgttgc ctaggctgga gtgcactggt gagatctcgg ctcattgcaa cctccacctc 62100 tcgggttcaa gtgactctcc tgcctcagcc ttctgaatag ctgggattat tggcacatgc 62160 caccacaccc agctactttt tgtattttta gtagagacag gctttcacca tgttggccag 62220 gctggtctcg aactcctggc ctcaagtgat ctgcctgcct ccccctccca aagtgctggg 62280 attacaggtg tgagccactg tgcccggcca agcatgtttc taagaaaagg gcaaacaatt 62340 ctcaaagagg cccctaatat ctaaaattgg tttagaatcc ctgccctagg tgaatacagg 62400 aaacactatc aaaactaaaa gggaacttgt agggcatctt aatcaatcaa ccaagatagg 62460 taccaaggcc caaaaccatg tagaggcttg tgcaagatca caagcagagg tgcaatttga 62520 agctagattc tcccactctt aaactagtgc cggacagacg aaggcctagc acatgggcta 62580 cggagcccta gtagattcca gtccccacac tgagccagga ggggtcgctg cccagggata 62640 cctacagcca tactcgagct ggacaaggcg cacgctcttt gtggaagcaa acacgtccac 62700 caccgcgtag aggggctgcg cagctggcag tccccgggcg ctcgggccca tgtcctcgcc 62760 gttgatgatg atgtgcatgt cggccgtgcc atcggggcgc gggcaaaaga ggacacccag 62820 gcggctacgg cgcgcggtcg gaggcagcac gttcagctca tagagctggt ccaagagatg 62880 gctgtagagc cctggccggc tgcggcccac caggcggtcc cggggaatgc gaaactgctc 62940 aatgcgcaga tatggttcca cgaggagggt tggaggtcgg ctgggggccg ctgcctccgc 63000 ctccgggcgg ccctcccggg gcacgcggtt gtggtggcgc gtgatggcga agacccaggt 63060 gtggcccagg ttgaccagat cgggcagaga aaactcggga acgggggcca gactggcggg 63120 gtccagcgcg gtcagaccga gacgcagatg tccgcaccag cccagctctt tctcctcgat 63180 ctcgaccagg aagacctggc ccggggccag cggctcgcgg ctgaagcaca cgccgtgggc 63240 gaagctctcc acgcgtgtgg cccgcgtccc agaggggtcc acgcggatgt tggcaccgtg 63300 cacccgatgg aagcgggtgg gagggggctc cgggcgctcg agtccccaga gtgcacccga 63360 atccacgggc tcggaggcag cagccatctc tcggccatag ggcaggccag ctggcgccgg 63420 gggctatttt gggcggcggg caatgatggt gaccgcaagg cgaccttgta aggcatttcc 63480 cccctgactc ccttccccga gcctctgccc gggggtccta gcgccgcttt ctcagccatc 63540 ccgcctacaa cttagccgtc cacaacagga tcatctgatc gcgtgcgccc gggctacgat 63600 ctgcgaggcc cgcggacctt gacccggcat tgaccgccac cgccccccag gtccgtaggg 63660 accaaagaag gggcgggagg aagactgtca cgtggcgccg gagttcacgt gactcgtaca 63720 catgacttcc agtccccggg cgcctcctgg agagcaagga cgcgggggag cagaggtgag 63780 ctggcaccgg aggctggagg ggatccccga gcccgggatc ggtgcgcggc agaggaggct 63840 cgcgggtggg agctggcgct ggggccgggg cttccctcgc ggaggcgccg ccagcaactc 63900 cccgggggct gctgcacgga agcgctgagg agcgagtcaa cagcccctct gctgcctccc 63960 gtagatgatc cgagccgcgc cgccgccgct gttcctgctg ctgctgctgc tgctgctgct 64020 agtgtcctgg gcgtcccgag gcgaggcagc ccccgaccag gacgagatcc agcgcctccc 64080 cgggctggcc aagcagccgt ctttccgcca gtactccggc tacctcaaag gctccggctc 64140 caagcacctc cactactggt ctgccgccct gccttctggg cgggattggg agaagagatg 64200 acggatgagg gatggggggt agttctgcag acccctgagg atgcctggga gccgggaggg 64260 ctggaaaggg cccctccaac tgcgccaacc ctgccctgac ccccctccca ggtttgtgga 64320 gtcccagaag gatcccgaga acagccctgt ggtgctttgg ctcaatgggg gtcccggctg 64380 cagctcacta gatgggctcc tcacagagca tggccccttc ctggtgagtg gacagcaggg 64440 ggaaagcaca gttcccaaag taaaaggctg gggaaagcga gagaggggct ttgtgatttt 64500 ccaaaaagtt tccttccttc taagcctcgg gattttcctc tatgccattg gctttgctgc 64560 ctgtacctct cagaggtttt acccacatgt aaagtgcctc tcatggtggc cctttccctc 64620 cacccagctg gcccttggga cttactcagc catctctttc ctcctcaggt ccagccagat 64680 ggtgtcaccc tggagtacaa cccctattct tggaatctgg tatagctgga gctgtgggtg 64740 tgtctgggca cttggatggg gtggcattta gctaattttt ccctcccctc tagattgcca 64800 atgtgttata cctggagtcc ccagctgggg tgggcttctc ctactccgat gacaagtttt 64860 atgcaactaa tgacactgag gtgagtctgg tgcctgccca tctgccccag gctccccggt 64920 cctccatcca tggcatgatg ctgggagaga gagcatggcc ttggagtcta cttttcgctc 64980 tgtcatatgc tattgtggta tggtggccag tcacttcctc ttgcacaaat agggtgggtt 65040 aatgtcatta tctctgaagt tctttccagt tcaaatacca aagcttcctg attccctctg 65100 tcttgctctg ccatccccag gtcgcccaga gcaattttga ggcccttcaa gatttcttcc 65160 gcctctttcc ggagtacaag aacaacaaac ttttcctgac cggggagagc tatgctggca 65220 tctacatccc caccctggcc gtgctggtca tgcaggatcc cagcatgaac cttcaggtgc 65280 agggtagctg caggagggaa gggaggtagc ttgaggctgt ggccttacag ttagcaaggt 65340 cagactgact ggtcaatgtc cccatccaac ccagcttcct gcataacctc cccaccaccg 65400 gctgccctag gtctgtctgt gtgcctccca cacaggaaac tcacctgtca ggctgccagc 65460 tctgtgtttt gcattgagtg gcctctcata cccaccggcc tacataaacc accctgggtt 65520 tcagcttccg gattgctgaa ggtctgggtg gtagggtgag ggaggctctt cctttttgcc 65580 ctccacatga gctgagcacc ctgggtgttt cacaggggct ggctgtgggc aatggactct 65640 cctcctatga gcagaatgac aactccctgg tctactttgc ctactaccat ggccttctgg 65700 ggaacaggta tgggataggg cagttgggca atctctgggg tgaggcaggt cacatgatct 65760 caggtctgtc ctccaggcac atgatatgac aggcccagcc caggtttatg agcagcaggt 65820 gggttgcaga aagaacctag tgctgaaagg ccaaagaata gagatcagtt tttctttctt 65880 tctttttttt ttttttgaga cagattctta ctttgtcacc caggctggag tgcagtggca 65940 cgatcttagc tcactgcaac ctccacctcc caggttcaag caattctcat gcctcagact 66000 cccaggcagc tgggactaca ggcgcgtacc accacacctg cctaattttt tgtattttta 66060 gtagagatgg ggttttgctg tgttggccag gctggacttg aactcctggc ctcaaatgat 66120 cttcccaaag tgctgggatt acaggcatga gctacagcgc ccagccagaa atcagatttt 66180 aaaggaacta aggaggcctg tctgtatgac cctggggcac ctctttggga gctagcttag 66240 atgacataca gaccacaccc tgtgatatct ttcccagtct cctagggtca gggaggttgg 66300 tgggaggtgg ggggtatgct cgcctcctct gccttcctct tcccaccagc agctgatgcg 66360 cttttcactc tcatctccta caggctttgg tcttctctcc agacccactg ctgctctcaa 66420 aacaagtgta acttctatga caacaaagac ctggaatgcg tgaccaatgt gaggttctgc 66480 catcactttg catgagctct cccatcccta atcctgagaa caggaccaca ttccctcctt 66540 ggggactcct tgttctccgt ccctcattgc tttcttgcac ctttaagcaa tttagtgttc 66600 tctgggacat gtgtctaagt gtgtattccc accaccacct cctatggtgg caaatcccat 66660 aacctccgtg aggagaaagg acttcttcac atttatcaaa cacctgcaac gtggcaggca 66720 ctgtgctgaa ctgtgtctat gtagattatt taagcttcaa gattccccct caaatgagat 66780 catactaccc acattttcca gataaggaaa ctgagggcta tgaattttga aatcactgtc 66840 tgaagtcaca gtgttgggag gcagtgatgc taggatttgg acccaggtct gggaagattc 66900 ctgccactga gcctcagttt ccctacctgt gaaaaaaagt gggtgaagag gtgaaatcca 66960 agagcagtaa atcttgggac aacttggtgg ggtcgtggag aggctgggga tctgtaaagc 67020 atggtggctt ggtgtatcat tgcagcttca ggaagtggcc cgcatcgtgg gcaactctgg 67080 cctcaacatc tacaatctct atgccccgtg tgctggaggg gtgcccagcc attttaggta 67140 ggtgctgctg ggtgcccctg gagccaaccc cagccccatc tggaggctcc acacccattc 67200 ccccacctca cattgcaggt atgagaagga cactgttgtg gtccaggatt tgggcaacat 67260 cttcactcgc ctgccactca agcggatgtg gcatcaggtg tgcgagggcg tgggcttcct 67320 cctggtgagg tgggggcagg gggaggggca gggaagcaga ggccctgacc cactgtctgt 67380 gccttccagg cactgctgcg ctcaggggat aaagtgcgca tggacccccc ctgcaccaac 67440 acaacagctg cttccaccta cctcaacaac ccgtacgtgc ggaaggccct caacatcccg 67500 gagcagctgc cacaatggga catgtgcaag tgaggttccg tggccacctg tgacttgggg 67560 tggtgggttg ctggggcttg tgggcatcgg caggtttctc agggatcttc tgtgtagagt 67620 ttctcaatga gatgagctgt agaggatgtt taacatccat ccctgacccc tcagtggatt 67680 gagagtcagc caattcattc ttttatcttt tttaaattta aaattttttt gtttgagaca 67740 aggtctcact ctgtcaccta ggctggagtg cagtggtgtg atcatagctc actgcagcct 67800 caaactcatg ggctcaagca atcctcccac ctccccagta gctgggacta cagacgcacc 67860 accaccccca acaagttttt gtattttttg tacagatggt gttttaccac attgctcagg 67920 ctggttttga actctggggc tcaagtgatc tgcccatttc agcctcccaa agtactggga 67980 ttacaggcat gagccacccc gcccagcccc atttcattac gtagccacat tggttgttgt 68040 ttcacagttc actacagcct caacctccta ggctcaagcg atcctcccac cttagtctac 68100 tgagtagctg ggtctacagg cacatgccac cattcctggc taatttttaa aaaatttttt 68160 tgtagagaca gggtctcact atgttgtcca ggttggtctc aaactcttgg tctcaagcaa 68220 tcctccctcc ttggcctccc aaagtgctgg gattacaggc gagggtcccc acacccggcc 68280 atcacattgg ttaataacta ttacttccga ctgggcgcag tggttcacgc ctgtaatcct 68340 agcacttttg gaggctgagg tgggggaatc acctgaggtc aggagttcga gaccagcctg 68400 gccaacatga agaaacccca tctctactaa aaatacaaca attagccagg tgtgctgttg 68460 ggcacctgta atcccagcta ttcaggaggc tgagggagga gaatcgcttg aacccaggag 68520 gcagaggttg cagtgagctg agatcatgct actgcactcc agcctgggca acaaaagtga 68580 aactccatct caaacaacaa taacaaactg ttaacttcca tgtccagtct cctgtggcca 68640 ccccccccca caaccccaag taaaagggta acactgggcc cagcagggct gctcaggtcc 68700 attttgattg gtcagtgctc acactctacc ctgttgtatg ttgtgactcc cacacctgct 68760 ggcccctaga cactaaatgc cagatgcatc ccagtcctcg taacaaccaa aatgcgtccc 68820 ttgtacattt ctttttcttt ttttttttga gatggagtct tgctgtcact caggctggag 68880 tgcagtgctg cgatcttggc tcactgcaac ctccgcctcc cgggttcaag tgattctcct 68940 gcctcagcct tctgagtagc tgggactaca ggcacgcacc accacgcctg gctaattttt 69000 gtattttttt ttttagtaga gacggggttt caccatgttg gtcaggctgg tctcgaactc 69060 ctgacctcgt gatccactca cctcggtctc ccaaagtgct aggattacag gcgtgagcca 69120 ccacgcccag catccctgta cctttctaaa tggtggtgag ttgaggctgt ctgaatccca 69180 gcccatccag cccaacatcc aagtcagtcc tagagaggtg gccccccccc aaaaagggga 69240 gtggaaccca gctgtctgcc ttctgggttg gagcttggag ataggagaga aggtctgatc 69300 tgttgactac ttttcgcccc gacctggtct tcctggggcc tgctcgtatg ttcccggcag 69360 ctttctggta aacttacagt accgccgtct ctaccgaagc atgaactccc agtatctgaa 69420 gctgcttagc tcacaggtga gtggggagag cacagctgga tcaccagcag ccttaggacc 69480 ccagagtagc acagcaagct gggggccctt gagacttcct gtcaggacaa gggaagctga 69540 aactccgaaa ggcgaagccc agggtcctgt gattggtggg gtcagaattt gaacctgggt 69600 ttgtccccac ccatgctgtc ctgctatagg aggcctaggg gtctgcatca gccacggagt 69660 cttaagggtg agaagagctt cattcatgcc aaaaatgggc cagcagaggt ccagggtggg 69720 aggagacctt gcacaaggtg atataggaag cactggcagg gccaagttag gactaggttc 69780 tgtccagcac agtggttaat agcatgggct ctggagtcac atggcctggg tgcaagtccc 69840 tgtactagcc acataatctt gggcaaattt cttaaatatg agcctcaggt tctccatctg 69900 taaaatgggg ataataatga tatctacctt cacagataaa acatttagta gaatactgga 69960 catgcagtaa gtcgttagaa aacatgaaaa ttccctggtt cgtgttatct agcttggccc 70020 cttgaatttc ctgaggggta ggccttgaac tagggaaggg ctggggactg ggcttgttcc 70080 acacccctca tttttacccc atcctgcttt agaaatacca gatcctatta tataatggag 70140 atgtagacat ggcctgcaat ttcatggggg atgagtggtt tgtggattcc ctcaaccaga 70200 aggtaaggta gagattcctg gccctgggat aggggctgct gtggaggatt gggagcgggt 70260 atgcctggga gtggccagct ggctgcctgg ctctggccca cagagggcaa gtgtggagga 70320 attcccagcc ctaaggtctt gctggtagct gtgagcaagg atgcagctgc tgtaggctga 70380 tgtctttcct ggtggggcag atggaggtgc agcgccggcc ctggttagtg aagtacgggg 70440 acagcgggga gcagattgcc ggcttcgtga aggagttctc ccacatcgcc tttctcacga 70500 tcaaggtagg gactgggcct gctgagagat aactgggccg gaggcaaagg agcaggaccc 70560 acccgtcctt tccctctggc tgccttttag gctgggtcat gggtcaccat ctggcccctg 70620 tatgggcaag tttttttgga gaggggtggg gagggttctg ggaagaataa agggtttggg 70680 atgaaggaat tgcccccgag tgagcagtta tatggggagg agggaatggt ggggtcagga 70740 gctcacgaac attgctcctc agggcgccgg ccacatggtt cccaccgaca agcccctcgc 70800 tgccttcacc atgttctccc gcttcctgaa caagcagcca tactgatgac cacagcaacc 70860 agctccacgg cctgatgcag cccctcccag cctctcccgc taggagagtc ctcttctaag 70920 caaagtgccc ctgcaggccg ggttctgccg ccaggactgc ccccttccca gagccctgta 70980 catcccagac tgggcccagg gtctcccata gacagcctgg gggcaagtta gcactttatt 71040 cccgcagcag ttcctgaatg gggtggcctg gccccttctc tgcttaaaga atgcccttta 71100 tgatgcactg attccatccc aggaacccaa cagagctcag gacagcccac agggaggtgg 71160 tggacggact gtaattgata gattgattat ggaattaaat tgggtacagc ttcaaatccc 71220 gtcttctctg tggcactggg ggttagaggg ggcactacag gctatgaatg tgggaaaaga 71280 ggggctgaga ggggttgggg tcctgaatga cagctgccag cttggggatt gagggctcag 71340 acagctgctg tggacggtgt gggggcagtg gacgccctga catcagcagg ccggttcttc 71400 tcaatcacct ctcgcagccc tttggcaaag tggagatcag ccccgatggt gaggaatccc 71460 tgtgttgggg agaggggagc ctcatttatt cattcagtta ttgaggccag agtttagaga 71520 tcaagagaca gagtgtttgt ctttcaggaa ctcaatctaa tggataattc catgtcaagg 71580 tgttaaaatg aggctgtagg agtgtagact atgggtgtca aggagggctt cttggaggag 71640 gtgacctctg agctaagacc tgaacaatta gtaggtattg ggatgggaga agagtgctcc 71700 aagaagtcac agtgtgtgca acggctttta ggagtctaag attaaaatgg gaggggcgac 71760 tggtaatggg ggagctgggg tcaggtaatg gagggcactg gggagctata gagagagggg 71820 aaggccctcc ctccttcccc atcctgcccc cactcaccgc atggttcgtc accacctcat 71880 gcacaaagtt gatgccctca ggtagtggga tctgcacccc acgccaggtc cgctctgtgg 71940 gtgggagcac cccgctcagt ctgggcccgc ccagttcacc cctcctttct tcctccatcc 72000 tcacacccca gccttaccat tgagcatggg catcacccca atctgcagca tggtcttcag 72060 aggggcctgt aatgggatca gctgggaggg gcgagggcgg aaacagggca gtgagtcagg 72120 gttgggtttg cctttagctg cccgcaggtg agcagttata tgaggagggg gggatggtga 72180 gggtcaggat ctcacgaacc cagcccagcc cacccaccct tccccactca cagccagcga 72240 ctccagtgca gaatggttgg aatagattcg gaacctgcgg gaaagaaagg agccctgtgg 72300 gcaggaagcc tggaagctcc ccttcctcag gccacccagg cctacctgcc agaggtgtct 72360 gagttgcagg ctcagatgcc cacctaggca cctttccaag tgctacaact ttccaggtat 72420 cctcggggca gtcattgctg ccacttgggt ctccttttct ccaagactgc tactttttat 72480 ttattgagca cctctttttt tttttttttt tttttttttt ttgagacaga gtctcgctgt 72540 gtcgcccacg ctggagtgca gtggcgcgat ctcggctcac tgctccgtct cccgggttca 72600 cgccattctc ctggctcagc ctcccgagta actgggacta taggtgcccg ccaccaagcc 72660 cagctaattt tttgtgtttt tagtagagac ggggtttcac cgtgttagcc aggatggtct 72720 cggatttcct gaccttgtga tccgcccgtc tcggcctccc aaagtgctgg gattacaggc 72780 gtgagccacc acgcccggcc tttattgagc acttctaatg tgccagactt ctgctggtag 72840 ctttgcaggt gttatttatt ttatgtaaca aaacttcaca ttgcttagtt cctgtcagac 72900 actaagcata tttattttct ttttttattt ttatttattt ttgagacagc gtctcactgt 72960 gttgcccagg ctggagggca gtggtgtaat tttactcact gtggctttga cctccagggc 73020 tcaagtcagc ctcccacctc aggcttccaa gtagctggga ccacaggcgt gcatcactat 73080 gaccaactaa cttttaaatt tttttgtaga gacaggatct cactttgtag ctcaggctgg 73140 tatcgaactc ctggcctcaa gcgatctacc cgccttggtc tcccaaagtg ttgagattac 73200 aggtgtgagc cactgcaccc agccaacgtg tttaaaaagt taatattagt aaactgtttt 73260 aaaatacagt accaactggt ttagtcctca aaacaagccc aaggagtggg cactattagg 73320 atttgcacta atttatagat gaggaaaatg aggccctgca aggttaagta atttgcctga 73380 agtcacacag ctggaaagtg tcagaagctg cctctagaac ctagggtcct aacctacatt 73440 atctccttta accttagaac agcactgtcc agtcagattt tctgtgaaac gttttgtatc 73500 tgcaccgtct actatggtag tcactagcca catgtggcta atgaaatgtg gcttagtgca 73560 actgaaaaac tatttaatta taattaattt aaatgtaaat agtcacatgt ggctagtatc 73620 taccatattg gatagcacag ccctagaagg cagatgctac ttttgcctgt attaaacaca 73680 tggagaaaat gaggcctaga aagacaaaat gggctgggtg cggtggctca cgcctgtaat 73740 cctagcactt tgggaggcta aggtgggacg atcacttgag cccgagaatt ggagaccagc 73800 ctggacaaca aagtgagacc ccatctctac aaaaaataaa atagtcaggc atggtagtgc 73860 atgcatgcag tcccagttac tcgggaggct gaggctggac gatcacttga gcccaggagg 73920 tcaaggctgc agtgagctat gattgcacca ctgcactcca gcttgggcaa cagagtgaga 73980 ctctgtctca aaaataaata aatacaataa aataaggcca agcacagtgg ctcataccta 74040 taatcccagc actttgggag gccggggcag gtgaatcacc tgaggtcagg agtttgagac 74100 cagcctgacc aatatggtga aaccctgtct ctactaaaaa tgcaaaaatt agccgggcgt 74160 ggtggcgcac acctgtaatc ccagctactc aggaagctga ggcagaattg cctaaacccg 74220 ggaggcagag gtggcagtga gtcaagacca cgctattgca ctccagcctg ggcaacaaga 74280 gcgaaactcc ttctcaaaaa aaaaaaaaaa agaataataa catttttaaa aaagataaaa 74340 tggcctcaag gtcacaaagc tgtgttgtgc tgaggttttt gtcaaaaccc atgttctgat 74400 ctttgctgtg tgactgtggg catgttattt aacattgctg gacccatttg ttcatctctc 74460 ataatacctg ccctgcctgc ctctgggaca tgtgagaatg cagaggagtc agactttacc 74520 aaagcacttt ggcatgcatt aacaaagaca gaccccagct ctcagtggct tacaggtatc 74580 actgtacttt aagcgcaaca tccctgtgga caggtgtgat tgtcctccaa tcactgaggt 74640 gcagggaagt gcgcctgcct acctgcgcag gtccagctgc gtgcgcaggg ccttcccccg 74700 gagagccatc ttggcgctga gacgggcgtc ctgcaggaac atggggagga ggatgttact 74760 gacccagaag gtcagtaacc cacagcccat ttttccctga cccccagcca gcagccccca 74820 ctctgggacc cgtaccatag tcatgctgga cagctggacc tcaggctggt ctggtgggac 74880 cagggcaatg gtgacgctag cagtgacaga gatggtggtg ccagagggct tgatggtgca 74940 gcgcggtggg gccaggaccc gcagctccag cttcaatggg gagtcaatca ctgctgggct 75000 ctgggggatg agcagcaggg gcgggtcaag tccctgccat ttcctttgga gcccccaggg 75060 aagaagggga aggaaggcag gtgcagcttc tgtcctctgg ggactctcat attgcaaata 75120 cagagggagc tctggcttcc aaaactctca catctgcatc tagccttcat gcctttgcca 75180 cacaaagaaa caggaatgtg ttcttctctt tctgcttcct aaatacatct caatattcag 75240 gtctatctcc aatccagact ctttgtggat gtcctttttg cattagtatc tcagcccttg 75300 ccatgtcttc tgtttttgat atggagtctc actttgttgc ccaggctgga gtgcagtggc 75360 acaatctcgg ctcactgcaa ctctgtctcc caggttcagg cgattctccc gcctcagcct 75420 cccaagtagc tgagattaca ggcacctgcc gccatgcccg gctaagtttt gtatttttaa 75480 tagaaacggg gtttcgccat attggccagg ctagtgattc gcccacctcg gcctcccaaa 75540 gtgctgggat tacaggcatg agccaccaca cccaaacccc ttgccatatc tttttgctct 75600 ctctctcctt tttttttgag acagggtctc tgttgcccag gctggagtgc agtggcatga 75660 tcacggctca ctgcagcctc aacctcctca gctcaaatta tcctgccaca tcagcctcct 75720 gaacagctga gaccacaggt tcatgccatc acgcctggct tatttttgta tttgtttttt 75780 gttttggttt ttgcttttgt gttttcgtag agacggggtt tggccatgtt gcccatgctg 75840 gtctcaaact cctgggctca agtgatctgc cggcttcagc ctcccacagt gttgggatta 75900 caggcgtgag ccaccgtgcc tggccatatc ttctttctct aaactgctat gccttcttct 75960 ataggcagtg aaggaatact ataagatgca actgcctaat cttcaccaaa catgattcta 76020 aacactgtat atgtgttggt tcctttaaac ctcataataa ccatgtgagg ccgatattat 76080 tactgccaat tttgttgttg ttatttttta caaatttatt tttcaggctg agtcgtcatg 76140 gcagagaatt gcttgaaccc gggaggttca attgcagtga gccaagattg cgccactgca 76200 ctccagcctg ggtgacagag tgagactttg tccccccacc gaaaaaaaaa gatctgacta 76260 aaaatttatt tttcaataga gacagtgtct cactgtgttg cccaggctgg tctcaaactc 76320 ctgggctcaa gcaattttcc taccttgacc tctcaaagtt ctcagagtat aggcgtgagc 76380 catcatgccc agccatatcc ccatttttga gatggggaaa ttgaggcaca gataggttaa 76440 gtaacttgta gaggttatgt agttactcag tttcagaact aggcttgaag cccaggcagt 76500 ctgacaatag agaccctgcc ctgccataaa ttggatgatg ataatgactg aattatttct 76560 tttaaaattt gtaattctgc taggtgcggt ggctcacacc tgtaatccta gcactttggg 76620 aggccaaaaa tgggtgatca cttgagccca ggagttcaag gacagcctga gcaacataat 76680 gaaactctgt ctcaacaaaa tataaaaatt agcggggtgt ggtggcacaa gcctgtaatt 76740 ccagctactc aagaggctga agcaggagga tggcttgagc cctgggaggc agaggttgca 76800 gtgagcctag attgtgccac tgcattccaa cttgggtgac aaagtgagac tcttgtctca 76860 aaaaaaaaaa taaataaaat gtgtaactct tactctcctc cccaatacac aaataaacaa 76920 aagtatatgt gaattattat taaagccctc acacttgcaa agcttgggtt ctcactaatc 76980 ctcacagcag ctctgcgaag gagatggggc aggaaggagc aggaaggagc agaccgcttc 77040 acagacagga acagccatga caaggcgagg gggattggcc acagacaaga ggccagggcc 77100 ctgtctgcgt ggctgccact gggggcccca cctgcacccc tccttggtct cactggtgtg 77160 caggtggccc tatccctgcc cccgccagca ctcaccagca ggacaatgct cccaaagtag 77220 gtggccctca gcagcatgtc caggtcgtgg ggcacctgaa caggggaatc aggagtgagg 77280 gagtgagctc tgtcacagac cttctcttgc ccatcccaca aacaggccat gacatacctt 77340 gtcccccacc agcaacagct gcagggcccc cgcccggaag tagctctcca tggcagagtc 77400 gaagaagaac tcagagaagg ccacatacac catccgctct tcctcctgca gctggggctc 77460 cactgcccgg ttggggaggc tccagttcct ctcagtcagg gggaagaagg ccccctgggg 77520 tggggcattc acagtcaggg tcaaggcaga ctggcctggc acctggactg acagcaggtg 77580 tctcccagcc ccgtgctagg cactgtgggg ggatggtggg aacccagctg ctgttcttgg 77640 aggattcaca agcacatctc ttaaaaggca ttggaaggag gacacctgct accagggggc 77700 gagcccgtca gactggagga gggagggtca ggaaaggttt cagggaagag gtgacatctg 77760 agtgggcctt gaaagctaga ggcagtaaca acagctactg tttacatata ttgtgcatac 77820 tcatgcttct ttgccaagta ctctaagctc ttcacataga tcgacttctt taatctgcat 77880 aacaacgtgt gttttcttac tagattattt ccatttacat gttaggaaac tggccaactg 77940 aaaacttatg cttagggccg tgcagctagt cagtggcaga gctaggattt gaacttcagg 78000 cattcttttt ctctttgtag agaaggaggt ctcactatga tgcccaagct ggtctcaaac 78060 tcctgggctc aagcgatcct ctcgcctggg cctcccaaag tattgggatt acaggcatga 78120 gccactgcac ccgactgatt ctagctcccg agtctgcact ctgaaactgc tatactcctc 78180 tgggagacca aaggtagtgg ctacacactg gctatgtggc cttgggcaag tgacgtcacc 78240 tctatgagta agtctccaca ttcctaaaat taggatgatg ttagtacctg actcacaggg 78300 ttgtgagaga atgaaatgag attatttgta tagaaattta tgtccagctc cttcggggga 78360 gttggggaaa ggccgtgcat gagcaaaggc cctgaggtgg gaagccaggg tccaatttgg 78420 gaaagagcag ctgcaaagaa acaggatgag atataaaagg tggggccagg taagattaac 78480 aggggctcaa atgccagacc caggaggctg aacctaattc tgtagtaaca gggagccata 78540 gcattctcag taatgggagt ggcctcatca gagctgtgct ttaagaagta aaatcttgca 78600 acttagcaga gaaagaggtc ttgttaggaa gtcagaggtc atacaccagc ccaagcagct 78660 cacccggaag tccatgtcca ggttgctggt ggaagccaca ggatccttca tgagggaata 78720 gtcaatgcca acaagctcgt ccacagaact gcgcactgca ggaaggggct caagtcactc 78780 acggctgtgt gatgtgggat aaggtgctta acctctccag gctcagaggc ccacccataa 78840 aatgaggata catccttcac agggttgtca tgagggtcaa attagtttta tgtggaaagc 78900 acttagggcc tggtgtgtag ttaggtgctc attaatgtta gttattatta ttactaccac 78960 tatagaggtt tcaaaaaaat aactaaacaa gatggcatgg gggggccgcg catggtggct 79020 cacacctgta atcccagcac ttagggaggt caaggcgggc ggatcacctg aggtcaggtg 79080 ttcgagacca gcctggtcca ccacggtgaa accccgtctc tactaaaaat acaaaaatta 79140 gttgggcatg gtggtgggcg cctgtaatcc cagctactca ggaggctgag gcaggagaat 79200 cgcttgatcc tgggaggtgg aggttgcagg gagccaggat tgcaccactg cactccagcc 79260 tgggtgacag agcgagactc catctcaaaa aaaaaaaaaa aaaaaaaaga tggcatgagg 79320 ttcctttccc ttggtttctc ctacctcctc cttcgcttcc catgcctgtg tgttaggtgt 79380 gatgggaaaa tacctttgcc ccacagtaga cagaggtcat ggcttagaaa aagggaattc 79440 atggccaggc acagtggctc atgcctataa tcccagcact ttgggaggcc aaggtgggca 79500 gatcaggagg tcaggagatc gagaccatcc cggccaacat ggtgaaaccc cgtctctact 79560 aaaacacaaa aaactagttg ggcatggtgg tgcacgcctg tagtcccagc tactcgagat 79620 gctgaggcag gagaattgct tgaacccggg aggtggagat tgcagtgagc tgagatcgcg 79680 ccactggact ccagcctggc aacagagtga gactgtaaga ctccgtgcaa aaaaaaaaaa 79740 aaaagaaaga aaaagaaaaa gggaattcat gttaattgag cacctattag atgctaggtg 79800 atgaagacaa atgggatgcc agtgatcagc atgcacatat tgaggacctt gacaactatt 79860 ctctcagata atcctcacag caaccccagg aggaggcact gccagccaag tgaggaaaca 79920 agcactttgc ccagacagaa atgagcactt cacccaaaat cgcacaacaa gtcagctcca 79980 ggggccacat ttgaacccag gactgttcaa cagcagggct cggaaggggc ctgctctgag 80040 gtgctgcatg acagctgcac acccagactc acccgccacc aactcaccag gcacggtgtc 80100 caggagggag ttgagcagga ccgtccctgc gtggtagagg acagggcaga tctgcgaggt 80160 gggagccaga gtcagggcct tctcaaagtg agagcatgcc cacccttgcc accctgcgac 80220 ctgtcgctgc ccacacctgc tggttgagga ggaagcgcat ccctgaggtg atgaacgtgg 80280 agagaaaatc atacaccttc ctgtgaggag aggagaggcc ggatgagccc agaacctgcc 80340 tccaccccag tccaggtcca ggagaaatca gtgactaggg aaatagtggc agtaggagtc 80400 ctcagcttca gcctgaataa cagctcctcc acgtaggttt tccaagaacc aggcccaaat 80460 tccctctcca gtctaattct caagacctcc tgacctactc tctggtccca tcagtcaaat 80520 gaatccaccc acattgcctc aaacccactc tgagcatccc cacatccatc ggcttactga 80580 tgccctccct tccgccctct gcattcctac tctgtatttt cccatctgag ctcagatgct 80640 tcctcttcca ggcagtcttc ccagattccc ctcctctgaa tccccaaagc attttcttag 80700 tccttctctc caggccctga tatcaaatgt tttttgctcc agataggctc tgagctcctt 80760 cctgcatcct cagggactgg catacacttt gtttgatgaa taaataatac tgacagtgta 80820 ccaacaccag gttataatcc atcatcttct ctcccccatc ctcttccaga acaagaacaa 80880 tatccccttc tcagcagcaa aaataaaaaa ataggccggg cacagttgct caggcctgta 80940 atcccagcac tttggtaggc cgaggcggac agaccacctg agatcaggag tttgagacca 81000 gcgtggccaa tatggcgaaa ccctgtctct actaaaaata caaaaaaagt agttgggcat 81060 ggtggtgcat gcctgtagtc ccagctactt gggaggctga ggcaggagaa tcgtttgaac 81120 ccaggaggtg gaggttgcag taaaccgaga tggcgccact gcactccagg ctgggtgaca 81180 cagtgagact ccctctcaaa aaaaaaatta ttatttttgt tattattatt tagagatacc 81240 aattattgag aatccagtac atggccaaat gtgcatatca gatagtcctc acagttactc 81300 ttatctaagt ggccagcact taaatataca tttatcatat gccaggtgct gttctaaatt 81360 tttttttttt tttttttttg agatggaatc ttgctctgtc accaggctgg agtgcagtgg 81420 cacgatctca gctcactgca acctccgcct cccgggttca agcgattctc ctgcctcagc 81480 ctcccacgta gctgggacta caggcacgtg ccaccacgcc cagctaattt ttgtattttt 81540 agtagagatg gggtttcacc atgttggcca ggatgatctc gatctgttaa ccttgtgatc 81600 cgcccgccca gacctcccaa attgctggga tttcaggcat gagccaccac agccagcctt 81660 gttctaaata ttttttacat ataccaacac aaataatcct gacaacgatc ttataaaata 81720 ggatcttata aaatgaggat attgaggcac caagcttcag tgacttggcc acgttcacac 81780 agccaggaag tgacagagct gagctttgga cccagttggt ctgattccca ggcctatgca 81840 ctttgcattg cgctaggcag atgagctgtg gggctcgaaa agggtgagct ggggttgggg 81900 ctggggctta cttgaaggtt cccccgaagg ccgcgtgcat tctggagaca gaggcctggc 81960 aggagacatt ggacactttc atccgtccag cgggatcccg ggagagctcc agaccagtgc 82020 ggatggacac accctcagct gaggcgttga tgtagccccc atcatagctg ccaggggggt 82080 taatattcac tccaggtagg agctcaattg agtcttcagt gcccccatgc atcaccatac 82140 ctcttaataa ggtttcacct ctttccacac atcctaccaa accttcctat caactcgtat 82200 gaaatgcata tgcctgtttc tgttacacag atgaagaaac ggaaactcag gaaggctaag 82260 ggggctgccc acagccccac agcacctcca gccctcctga cccactctcc actcccctga 82320 gggtgctggg tccttacaag aaccagtaga gcagctgtct ccggaagcgc agccccaagg 82380 aggcattggt gatttgaagc atcagctcct gctgtggctg gaaatcgagc tcggaagatg 82440 tcagttgcag ctctgtgacc ttcaccctac aggaggcctc agggtcagat ccagggccaa 82500 gaagagggaa cttcccccaa cgacaggaaa tttgtctgct cccctttcaa gtccaggcct 82560 ggggaagcgg gagtgggtgg aatgaattct tccattgtcc ctcaagtgcc caacttagac 82620 ttgggtggct caaagttgaa cttgggtggc tgagagagga ggtcttcctg atccaggtgt 82680 taaaaatgag cttcacccca tcgcttaaaa gtcttgtttg tttgtttgcc aggtgcggtg 82740 gtggctcatg cctgtaatcc cagcacttta ggaggccgag gagggcggat cacttgaggt 82800 caggagttcg agaccagtct ggccaacata gtgaaacccg tctctaccaa aaatacaaaa 82860 cttagcagac cgtggtggca cgcgcctgta gtcctagcta ctcgggaggc tgaggcagga 82920 aaatcgcttg aactcgggat gcggaggttg cagtgagcca agatcgcgcc actgcactct 82980 agcctgggca acagaacaag actccctctc agaaaaaaaa aaaaaaaaag tcttgtttgc 83040 ttgcaccccc tcccctccca caccctgggg ttgctacacc cggtctttta atagagtccg 83100 ttcactttgc ctccatcacc taagctccgt ctcacatctc aattccttat tccccctccc 83160 tcatcctaaa ccatacttag agccttcagt ttctccaccc ctccgattaa ctccaccccg 83220 tgcccgagac tccactctca tctattggga agttccttga ctccaccttt ctgttgttct 83280 tcgaccacgc ctcacatcca ctggtcctgc ttccttcttg gccccctcta cattttcaag 83340 gccacgccca tctgcctggt cccgcctatg atgactggct tggcctttat cttttcggcc 83400 ccatccggtt tcttaagtct tgcctcatcg atttggccac gccccatccc actcagcctc 83460 cagtctcccg agaccctgag atttctcggg ccccgcctcc accgccgagg ccccgccccg 83520 gatcgcgagg ccccgccccc cacttactca gagatgttgt agtagaagtg gccttctttg 83580 ccccgcaggt ccggaatggt gatagtctcc agctcttgct ccagaaagcg cagcccctcc 83640 tgcttcactg aagcagcaga gaaaccctta cttagctccc gtgcccactg ttggggcgac 83700 cccaaccccg tccgctcccg tccgtccctg tctgcccctg cgccttaccc agctccagcg 83760 ccttggaggt gacgcggatc ttgcagcctg ggaactctgc atgtgcgcct gccagcagcg 83820 ctaggaagag ggccccgaag agggccatgg cgagcgggcc tgggggtggg gtggggtcgc 83880 aggagttatc tgagccgctt aaacccattc cttggacgtc caaccataag tgggaactag 83940 cctggatcgt taccctccag ataactcttc ggggaacttg gaaccaataa tcttgcctcc 84000 atatggcaga tgtggaaact gaggctcaga gaggcgatgc gacttgcgtt ctggctccca 84060 gaggatttgg gacacggggg aggggacgtt cccagttccc tcgtgctacc gccgcgtgat 84120 gagtttggac ctccagggga ccagccccca cacccccaac aacctcccct ttcctttagc 84180 ggtgggccca tgcaggcttg cacgttgcca cggcaacgac tgcacgcgca ttcttggagg 84240 gtggcttgcg gtctcatagg cctcgcgccc ggggaggaga ggaggtggcc gaccagaccg 84300 tgggctcccg ggtctcccgg ctccctcagg tcctaaatct ctcccattag agattctgcc 84360 tggagccccc atgttagcgt tctccttcat cggctctcct ccccacgccg gcttcagtgc 84420 accacgcggc tcggcgaggg actgggaacg ggatagggac gcgccccaac tcactcagcg 84480 gtggagctgg ggggcggcgc ggtcacgtgg gatggcgggc agctcagggg atccgggcga 84540 cggggtctgg cgggcagggt tgttccagcc gcctttataa agccggcctc cccgacccct 84600 cctcctctct gcagctctcc cctcctccct tgggggctgg gaggggacgg ggcgggacgc 84660 tggcagccgg gagagtggaa aaggctgcac agagccccgt gacaagcccg gccgctgtct 84720 ggacaagtgg gagacccaag cccagggaga gggaaggaaa tgcaggagcc ggcccactca 84780 gccccaacaa tcccactttg ctgggacctt ggttcaaatt acaattatcc atgtcttcct 84840 gcatgatctt gggcaagtca cttcacttgg gtcactgacc ctcagtttct tccttcagcg 84900 aaatgtgcac gatgatagga actacctctt gggcctttat tacaaccagg tccaggcaca 84960 aagtcaagga atattttttc tttccctgcc acccacaatc atctcgggac ctccttgcct 85020 ggctttgcta tgggcccccc tacctgtctc tgtgtcacca cctggggacc ttaaggtccc 85080 agagaccttt cccacttggg aaagcaagac tagacaagtg ctgtcagccc aggaacatac 85140 cacaccggct gaaatcagaa ggaggtctgc catttatcgt ggctggtgga ttgttttttc 85200 tatttttttt atttttattt tttgagacgg agtctcgctc tgtcccccag gctggagtgc 85260 agtggcgcga tctcggctcc ctgcaagccc cgcctcccgg gttcacgcca ttctcctgcc 85320 tcagcctccc cagcagctgg ggctacaggc gcacgctgcc acgcccggct aatttttttt 85380 gtatttttag tagagacggg gtttcaccgt gttagccagg atggtctcga tctcctgacc 85440 ttgtgatccg cccgcctcgg cctcccaaag tgctgggatt aaaggcatga gccaccgcgc 85500 ccggtccact ggtggatttt ttaatgaacc cttggagcaa ggtgctctga acagcatccc 85560 cgcccccacc cccaccccca cctccatcta ctgcttacag ggttcccgga ccctaggaca 85620 gggcacagag tgggtgcttg ccaccttttt gttgccaaat ggacgaaaga aaggggaagc 85680 aataatcatg tctgctgagc atgtatttag caccaaacac tcatctagga aggatgacta 85740 actcatcctg atttgcctag gactttcccc attgtgtctt ttttttctga tataatccac 85800 agattcacaa aaatagttcc atttcctttt ttatttaatt aattaattaa tttttttgag 85860 acacagtcgt gctctgtcac caggctgcag tgcggtggtg tgatcttggc tcactgcaac 85920 ctctgcctcc tgggttcaag tgattctcct gcctcagcct cccaagtagc tgggactaca 85980 gccatgtgcc accacacctg gctaattttt gtatttttag tggagacagg gttttgccat 86040 tttggccagg ctggtcttga actcctgccc tcaagtgatc 86080 <210> 59 <211> 804 <212> DNA <213> Homo sapiens <220> <223> Genbank Accession No. W22366 <220> <221> unsure <222> (1)..(804) <223> n = a or c or g or t <400> 59 tttnggccag cngtgctggg gagggaggaa gggtgatact ccagggttag ccgtcttctt 60 ttgggggtgt gtaccagccg nttttttcgt ggatctgcac caaggacttg taggactgct 120 gtgctcttgt cagactgtat tgagatttgt tggctccaaa ctgcactcgt gctttcccct 180 tcaccagtgt ggcactgatc tgcatgatca ctgactctat ggagtaggca ctgctccagc 240 cctgtttggt gagaagttcc atgcagatgg cccctccgcc cagaacatac cctccagaga 300 ggactggaga cacaaccctg acaaatgggg ggtcaaaggg aaagttatct ttaaaggaaa 360 aagttaagta ggaattgaag tcgggntcct tctttctctt tgganggatc tttggagatc 420 gnnggnggca aaaggngntt gtcccngggg ncaaactttn gggggggagg gttgggnnaa 480 atcccaantc aaatncaaag acntttgcca antnccaaac ggagntttcc gggcntttta 540 aatttgggnt ttccccnccc cctnnggggg aaaacntccn ttngggnaac cccgggggat 600 tttttttttt ttccccccga aaagnntttc cccttnncca aaanaaaaaa nccccgggnc 660 caaaaaaggg ggggcccccc nnnaaacccc cngggggccc caaagagnna nnattttnna 720 aacnccccaa annnnnnnng gggggnaaan ncnntttggg gcccccccnt cggggggncc 780 ccccctttnn nnnnaaannc tctn 804 <210> 60 <211> 691 <212> DNA <213> Homo sapiens <220> <223> Genbank Accession No. AI433892 <220> <221> unsure <222> (1)..(691) <223> n = a or c or g or t <400> 60 cacaatatgc atttattaat gaatgtattt atacacaata caaacgtgcg gggacaccgt 60 ccccttcaca gcccagaacc cagggtcaga agatgaggga tccagcctca gaggggagat 120 atgcgacttc ccaagagcag ttcttggcct ggaggggcca tgagagtgca agacacgggg 180 ccgtggccgg ggcggggcta cgggagcggg gcgtggccgg cccctgaggt tactataggg 240 gaatgggccc cggccaggtc ccctctcctt ggggcagtgg gaagacagcg gggcccacgg 300 gccagagctg ctacacgtag gcgtttctgc cgtatttgcc aaagctgctg tcgccttctt 360 ggtccgaggt ggcgacgggc atcacggaca cgggagcctg gtagggccgc cgggcgctgg 420 cggctgggtc ctcgtcagag ccgcagcagc aggcggagca gaggcagagg ccacccagga 480 ntgagatcag tgaggcgctc caccccaggt agagggcggt gcccagctcg tacttggttn 540 ccgggtacaa ggggtccgag aagtccccgg gtgatgtgna gggcgtacan gaggatggca 600 ccatcccgca gatacccggc aagattgtga ggggcccctg cgtggcccgc agcttggctt 660 tcctgagagc tcaggccccc aatgtggtgc a 691 <210> 61 <211> 537 <212> DNA <213> Homo sapiens <220> <223> Genbank Accession No. AA029831 <220> <221> unsure <222> (1)..(537) <223> n = a or c or g or t <400> 61 ctggtgatag tcacagtggc cgagtgagtt tcttgggggc ccagcttcct ccagaggtgg 60 cagcaatggc ccggctacta ggggacctag acaggagcac gttcagaaag ttgctgaagt 120 ttgtggtcag cagcctgcag ggggaggact gccgagantg ttgcagcgtc ttggggtcag 180 cgccaacctg ccggagagca gctgggtgcc ctgctggcag gcatgcacac actgctccag 240 caggccctcc gtctgccccc caccagcctg aagcctgaca ccttcaggga ccagctccag 300 gagctctgca tcccccaaga cctggtcggg gacttggcca gcgtggtatt tgggagccag 360 cggccctcct tgattctgtg gccagcagca gggggctggc tgccgcatgt tgcttgactt 420 tcggttggcg ggtggatgta acaatctcca ccagtgccct ggctcgctnc ctgcagccga 480 gcgtnctgat gcagctgaag ctttcagatg ggtcagatac cgctttgagg tccccac 537 <210> 62 <211> 592 <212> DNA <213> Homo sapiens <220> <223> Genbank Accession No. AI279571 <220> <221> unsure <222> (1)..(592) <223> n = a or c or g or t <400> 62 tcgtaaatca aagtactatt ttattaaatg agttatttta cacaatatga acatcaatat 60 aattacaatt gtaaaaaaat tttttataac aaggatggac tgattttcat atttccaaat 120 cagagtcaac tgtacattta cacagaattg tctttgcatg aagcccaaga gggaacagca 180 taaaaatgag tgtttctgta gcccctttat ttttgctgat caacagtttg ttagaaaagc 240 agctgcaggt atgttaccta aggtctgaga cagtagaaga gtcaaaggtg tcatgaattc 300 acctgtaaac aaccttatgc ctgaacatca gctaattctg gaggaagtgg agtcttagga 360 tgcttgctct caaagtgctg cttgaaggtc ttagggtctg gcatttgtgt cctacagaca 420 gtgcaggtat atattaaggc agctttggca gcagcctttt ggtcatgtcc ttgtttcttc 480 ttttgtccag cttgcttttt ggcatttttc tgctgagact gaattttctg ctgtccacga 540 gccatatccg ggccgngaca gtcttgcgtc ggagagacag tgcagcgcga ga 592 <210> 63 <211> 460 <212> DNA <213> Homo sapiens <220> <223> Genbank Accession No. AI982714 <400> 63 tcatttttat ttatttattt atatttaatt ttttttcaga catcagtgtt acttgccaag 60 accctcattt ttaaactcca acgagttatt acgttccttt ccactcttgc tttccaattc 120 ctacaccaag acaactctgt attttgagta tatgagtcaa gtatggcaaa aagtacagta 180 ccttaaaaac ttttatttta gtccttcctg gcccatgcta aaacttatat ctagaaatac 240 ggcaaaacaa aatgaaacag atctctcctt gtacataaaa cagctaaaaa tttggcctct 300 ttattgatct tatgtcatgt atttggcttg aaaaaaaaaa caacaacaaa acaaacagtt 360 acaagggtta aacaaactaa atttttcttc taaatctcta aatgctcata gacagccaac 420 ttgcagggca tacacagtgc cttgagagtc ggtcccacag 460 <210> 64 <211> 2805 <212> DNA <213> Homo sapiens <220> <223> Genbank Accession No. D87442 <400> 64 ggctacggca gggggtggct ctggggctga cccgggaagt cggggtctcc ttcgccttct 60 gtctttctgc gtcctactag caggtttgtg caggggaaac tcagtggaga ggaagatata 120 tatcccctta aataaaacag ctccctgtgt tcgcctgctc aacgccactc atcagattgg 180 ctgccagtct tcaattagtg gagacacagg ggttatccac gtagtagaga aagaggagga 240 cctacagtgg gtattgactg atggccccaa ccccccttac atggttctgc tggagagcaa 300 gcattttacc agggatttaa tggagaagct gaaagggaga accagccgaa ttgctggtct 360 tgcagtgtcc ttgaccaagc ccagtcctgc ctcaggcttc tctcctagtg tacagtgccc 420 aaatgatggg tttggtgttt actccaattc ctatgggcca gagtttgctc actgcagaga 480 aatacagtgg aattcgctgg gcaatggttt ggcttatgaa gactttagtt tccccatctt 540 tcttcttgaa gatgaaaatg aaaccaaagt catcaagcag tgctatcaag atcacaacct 600 gagtcagaat ggctcagcac caaccttccc actatgtgcc atgcagctct tttcacacat 660 gcatgctgtc atcagcactg ccacctgcat gcggcgcagc tccatccaaa gcaccttcag 720 catcaaccca gaaatcgtct gtgaccccct gtctgattac aatgtgtgga gcatgctaaa 780 gcctataaat acaactggga cattaaagcc tgacgacagg gttgtggttg ctgccacccg 840 gctggatagt cgttcctttt tctggaatgt ggccccaggg gctgaaagcg cagtggcttc 900 ctttgtcacc cagctggctg ctgctgaagc tttgcaaaag gcacctgatg tgaccaccct 960 gccccgcaat gtcatgtttg tcttctttca aggggaaact tttgactaca ttggcagctc 1020 gaggatggtc tacgatatgg agaagggcaa gtttcccgtg cagttagaga atgttgactc 1080 atttgtggag ctgggacagg tggccttaag aacttcatta gagctttgga tgcacacaga 1140 tcctgtttct cagaaaaatg agtctgtacg gaaccaggtg gaggatctcc tggccacatt 1200 ggagaagagt ggtgctggtg tccctgctgt catcctcagg aggccaaatc agtcccagcc 1260 tctcccacca tcttccctgc agcgatttct tcgagctcga aacatctctg gcgttgttct 1320 ggctgaccac tctggtgcct tccataacaa atattaccag agtatttacg acactgctga 1380 gaacattaat gtgagctatc ccgaatggct gagccctgaa gaggacctga actttgtaac 1440 agacactgcc aaggccctgg cagatgtggc cacggtgctg ggacgtgctc tgtatgagct 1500 tgcaggagga accaacttca gcgacacagt tcaggctgat ccccaaacgg ttacccgcct 1560 gctctatggg ttcctgatta aagccaacaa ctcatggttc cagtctatcc tcaggcagga 1620 cctaaggtcc tacttgggtg acgggcctct tcaacattac atcgctgtct ccagccccac 1680 caacaccact tatgttgtac agtatgcctt ggcaaatttg actggcacag tggtcaacct 1740 cacccgagag cagtgccagg atccaagtaa agtcccaagt gaaaacaagg atctgtatga 1800 gtactcatgg gtccagggcc ctttgcattc taatgagacg gaccgactcc cccggtgtgt 1860 gcgttctact gcacgattag ccagggcctt gtctcctgcc tttgaactga gtcagtggag 1920 ctctactgaa tactctacat ggactgagag ccgctggaaa gatatccgtg cccggatatt 1980 tctcatcgcc agcaaagagc ttgagttgat caccctgaca gtgggcttcg gcatcctcat 2040 cttctccctc atcgtcacct actgcatcaa tgccaaagct gatgtccttt tcattgctcc 2100 ccgggagcca ggagctgtgt catactgagg aggaccccag cttttcttgc cagctcagca 2160 gttcacttcc tagagcatct gtcccactgg gacacaacca ctaatttgtc actggaacct 2220 ccctgggcct gtctcagatt gggattaaca taaaagagtg gaactatcca aaagagacag 2280 ggagaaataa ataaattgcc tcccttcctc cgctcccctt tcccatcacc ccttccccat 2340 ttcctcttcc ttctctactc atgccagatt ttgggattac aaatagaagc ttcttgctcc 2400 tgtttaactc cctagttacc caccctaatt tgcccttcag gacccttcta ctttttcctt 2460 cctgccctgt acctctctct gctcctcacc cccacccctg tacccagcca ccttcctgac 2520 tgggaaggac ataaaaggtt taatgtcagg gtcaaactac attgagcccc tgaggacagg 2580 ggcatctctg ggctgagcct actgtctcct tcccactgtc ctttctccag gccctcagat 2640 ggcacattag ggtgggcgtg ctgcgggtgg gtatcccacc tccagcccac agtgctcagt 2700 tgtacttttt attaagctgt aatatctatt tttgtttttg tctttttcct ttattctttt 2760 tgtaaatata tatataatga gtttcattaa aatagattat cccac 2805 <210> 65 <211> 737 <212> DNA <213> Homo sapiens <220> <223> Genbank Accession No. AI816034 <220> <221> unsure <222> (1)..(737) <223> n = a or c or g or t <400> 65 tttttttttt tagtcttatc atttactttc cccaccccac attcttggaa cagcctttag 60 ttctacagga aatggcactg atggacagaa gactagcatt accttcatga aagggctgtt 120 agagctgcct gggaagaagg cgtgccttgg ggaactggga agatgccgtc agtgtgggtg 180 ggcaggagga cagccagtcg tcctgctgcc agcccaatag cttccagcgg caggtgccca 240 ggtgctaccg gagcccctca taggggtagg ggcagggact gcacctcctc caggcactca 300 tcgtaagcct cctggtactc ctcatggggc ttgaccatta tcacacaggt ggggcgcttg 360 gagcctgcgg ctgcacccag gtccgtctta gaggggatat agacataggg caaatttcgg 420 tcctcacaca tgactgggag atggcagtat acctcaatgg gcagtgtgtc tcctgccaaa 480 accatgatcc ctttttctcc tttgttgaca aatttctgaa cctctttcac cccgcgccga 540 atctgcttct gcttcaccgc tttcttgatg catttgtaga gctttcgcgt gaggcggcga 600 gaagcccagg gctgcgccga tgggttctgg ttgacagcag cttcctgtag gtgcgcttcc 660 ccgaacacgc ctncgcctga gcctngggcc cccgtcgatc tggcctttaa tttgtcatcg 720 cagcggccgc tgaaacc 737 <210> 66 <211> 505 <212> DNA <213> Homo sapiens <220> <223> Genbank Accession No. AI634570 <400> 66 tttttttaat tttgtaaaaa atggtttatc aattccattt ttgtataaaa cacacgggag 60 aaacctagcc aatcaacaca caactgtcac cacatgaaaa ggtactttta tcaaacttcg 120 agtctaagaa catacaaatg tttcttttat catgtctaca gtaattgtct atgcttttcc 180 atttaactgt tgttaaaaat tccacatatc cccattattt cttctgtccc agttacagta 240 caatgacggg gaggaagagg gttggttaaa gcatccctct aagcagtttt ctgctgtccc 300 ttctttccaa tcagagattt gtggatgtga gggatcacac ctctgcagtg aggtactcca 360 gaatcgcagc actgtacacg gcagcagtgg cacccaccct tccatggctt gtggtgcgag 420 tcttcaagtg tctgtggatg cggcccacag gaaactgtag cccagctctc tgtgagcgag 480 atactgcctt agccttggcc tttcc 505 <210> 67 <211> 805 <212> DNA <213> Homo sapiens <220> <223> Genbank Accession No. AI023344 <220> <221> unsure <222> (1)..(805) <223> n = a or c or g or t <400> 67 ttcattaaag tccatggatc atcacaaaaa cccaggaaat gcaactaagg agaaaacaaa 60 cgtccaacca agatctaaga acccagagct atggaggaga cgttgcactg gactgctggg 120 tgtgcacaag ggggcaggag gggcgatccc catggggcat ggccactggc catgggaaac 180 acaggaggga ggccaggcag ctggctgggc ggttatgtta accgctgcac gatgacagca 240 ttgagcaggt tggcttcctt cagggtctgg ctctcatcag ccagctcttt gttcgggaaa 300 gtagtcatga ggataaagct ggtggcagcc atggctggcc gggcatccac gatgaagagt 360 cggatgtcgc tgatcctgtg gctgtggtta aatttctgca ccagcctccc gccgtctgca 420 agccgaattt ggatgtttgt ggtaggctct gattcgtcga ttaagatgga agagctggct 480 ttggcttcat tttctgcctg ttgggctgga gagctggtac tcaacacctg gggggcagtg 540 ctgcccagtt tctgaccctc gccagtgaag gctttgaagg ctcctttggg cttcacaaag 600 tcctcgtccc gatggtcctc catatccaag ttcacctgtc caccgtgagc tagcctccga 660 agctctgctg gcacctcccc tctgcggata gactccagaa actgggcatt ggatgggnct 720 tgtagcttct gaggtctcca ttatcccagc tggatccact cttccaaagg ttcatactac 780 atgaaccatc ttgcttgaaa tgctg 805 <210> 68 <211> 1529 <212> DNA <213> Homo sapiens <220> <223> Genbank Accession No. Z14000 <400> 68 ggctgctgtt tctaaaaccc ctttccctct aacccacacc acctttctac tcactgatgc 60 cttcaggaag ccataatgga tggcacagag attgctgttt cccctcggtc actgcattca 120 gaactcatgt gccctatctg cctggacatg ctgaagaata cgatgaccac caaggagtgc 180 ctccacagat tctgctctga ctgcattgtc acagccctac ggagcgggaa caaggagtgt 240 cctacctgcc gaaagaagct ggtgtccaag cgatccctac ggccagaccc caactttgat 300 gccctgatct ctaagatcta tcctagccgg gaggaatacg aggcccatca agaccgagtg 360 cttatccgcc tgagccgcct gcacaaccag caggcattga gctccagcat tgaggagggg 420 ctacgcatgc aggccatgca cagggcccag cgtgtgaggc ggccgatacc agggtcagat 480 cagaccacaa cgatgagtgg gggggaagga gagcccgggg agggagaagg ggatggagaa 540 gatgtgagct cagactccgc ccctgactct gccccaggcc ctgctcccaa gcgaccccgt 600 ggagggggcg caggggggag cagtgtaggg acggggggag gcggcactgg tggggtgggt 660 gggggtgccg gttcggaaga ctctggtgac cggggaggga ctctgggagg gggaacgctg 720 ggccccccaa gccctcctgg ggcccccagc cccccagagc caggtggaga aattgagctc 780 gtgttccggc cccaccccct gctcgtggag aagggagaat actgccagac gaggtatgtg 840 aagacaactg ggaatgccac agtggaccac ctctccaagt acttggccct gcgcattgcc 900 ctcgagcgga ggcaacagca ggaagcaggg gagccaggag ggcctggagg gggcgcctct 960 gacaccggag gacctgatgg gtgtggcggg gagggtgggg gtgccggagg aggtgacggt 1020 cctgaggagc ctgctttgcc cagcctggag ggcgtcagtg aaaagcagta caccatctac 1080 atcgcacctg gaggcggggc gttcacgacg ttgaatggct cgctgaccct ggagctggtg 1140 aatgagaaat tctggaaggt gtcccggcca ctggagctgt gctatgctcc caccaaggat 1200 ccaaagtgac cccaccaggg gacagccaga ggaaggggac catggggtat ccctgtgtcc 1260 tggtctatca ccccagcttc tttgtccccc agtaccccca gcccagccag ccaataagag 1320 gacacaaatg aggacacgtg gcttttatac aaagtatcta tatgagattc ttctatattg 1380 tacagagtgg ggcaaaacac gcccccatct gctgcctttt ccattgccct gcaacgtccc 1440 atctatacga ggtgttggag aaggtgaaga accctcccat tcacgcccgc ctaccaacaa 1500 caaacgtgct tttttcctct ttgaaaaaa 1529 <210> 69 <211> 549 <212> DNA <213> Homo sapiens <220> <223> Genbank Accession No. AA632300 <400> 69 tagaaaacaa aaatggaaca tttattcgca actcaaatac tacgcatata cggtaagaga 60 ttaaatataa acacagcaag ttccacccca gtcctatttg tccaaggctg catggtcaaa 120 tggaatcttg aagagaacac ctggacaaca gaggacctgt cagcgacgtc tccggtctgg 180 acttctgctg cgtcttcggc cacctctcct cttgcctttt ggtggacccc gaacaaaaca 240 ccagtcaacg ctgatgggct gtcccatcaa atcctggcca ttgagtccct ccatagcagc 300 ctgggcttcc ttgtatgttt catattcaac tagagtatac cccttcagat atcctgttcg 360 cctgtcgaag ttgagatgaa tgtttttaat ttccccatat tctgcgaatt tgtcgtgtat 420 gtcttcttcg gtggcttcct catggactcc agttacaaag agaatccagc cttcaacaga 480 gcgttgtggt ccgggttcat cgccatcctg ctccacgctg tcataatcct cacgcatccg 540 cgctcggga 549 <210> 70 <211> 460 <212> DNA <213> Homo sapiens <220> <223> Genbank Accession No. AI798743 <400> 70 gagaatccag ctttgatctt tattcaagag accagatggg tgggcgcagg atccggctgc 60 cagccctgag gccaagcacg gctggagacc cacgacctgg cctgccgttg ccctgagctg 120 cagcctcggc cccaggatcc tgctcacagt caccgcaggt gcaggcagga agcagccctg 180 ggggactgga cgctgctatt gattcattaa aaaaagaaaa gaaaaataca cccaggcctc 240 aagtttcccc gtaacagtag ggcctgaggg gtcggcggtc ttgaggatct ggaaagagca 300 catgagggtc tcgtccacac tcatcatggc gccagcattg tcaaactcgc cacagtagtt 360 gggagctgag aaaagtgtca ccagctgccg cttggcaaag aactcgtagc cgtcttctac 420 cacctggtgt gctcggcaga tgaggtccaa gtcgtgcttg 460 <210> 71 <211> 635 <212> DNA <213> Homo sapiens <220> <223> Genbank Accession No. H98166 <220> <221> unsure <222> (1)..(626) <223> n = a or c or g or t <400> 71 cctaaagcaa gtaactttat tatcattcct ttaaaaagaa ccaaggaaaa ttcacaacat 60 atgtgaaaca caaacagctg tggtttagga ggtaaacaaa ggaccaacat agccctgaaa 120 tgcaacagcc tctgagtgac ttgagccgca tgtgactggg gttctgttaa aagggcaggc 180 ncctccctcc tagccctgaa gccccaggaa cctgccttga aagacaagct ctctaatact 240 caacttgcag ggtctcgccc taacatccaa gacttggtag catctccttt ctcccaaaac 300 ccagctggaa ctcaactaat cctaaaccga aaactcaaga acagcacacc agatgccacc 360 tgttgtttgt cagggtcttc aaacttccag aggaaatggc atttgcctgt catggttttc 420 ctctctaagg gcacctgtct gaacttggag ctgtgcttcc actggtgcct catggggcct 480 ggggctactc tccacctgaa ttcacacttt tcnctataag ggatcaggtg gggaataagt 540 ccagaaggtg acaagagggt cccgggcaaa gagcttgnca ttcctggnag ggatttccca 600 aatggccccg anggttggcg aggcgggaag naaaa 635 <210> 72 <211> 534 <212> DNA <213> Homo sapiens <220> <223> Genbank Accession No. AA039699 <220> <221> unsure <222> (1)..(534) <223> n = a or c or g or t <400> 72 ggtgagggcg ggcggagatg tagacccggt agtgttgtgc cttgtggtga caactggcgg 60 cacgcgccgg ggcccgagac ttagtctcgc acnantnggc caagcagtcc acgagagcct 120 ctacttcaat cccatgatgn nccaatgggg ttgtgcacgc caatgtgttc ggcatcaagg 180 actgggtgac ngccgtacaa gatcgcggtg ctggtgctgc tgaacgagat gagccgcaca 240 ggcaagnggc gccgtccagc ctcatggang cggcggagnc tcaaccagct gctcctgccc 300 ctgcttgcag ggcccaggat attacacttg tcaaaacttt acaagttaat tgaagagtct 360 tgtccacagc ttggcaaatt cagtgcagat cagaatcaaa cttgatggct tgaaagcgag 420 tttgaangat attggaacag tttttttgat gacctttcag attctttctc tggaactgaa 480 ccagaagttt cacaaaacaa gtgtagtaag gttgttttct gcgtcaaatg atct 534 <210> 73 <211> 981 <212> DNA <213> Homo sapiens <220> <223> Genbank Accession No. D78132 <400> 73 ctgaggaggc cgccaagatg ccgcagtcca agtcccggaa gatcgcgatc ctgggctacc 60 ggtctgtggg gaaatcctca ttgacgattc aatttgttga aggccaattt gtggactcct 120 acgatccaac catagaaaac acttttacaa agttgatcac agtaaatgga caagaatatc 180 atcttcaact tgtagacaca gccgggcaag atgaatattc tatctttcct cagacatact 240 ccatagatat taatggctat attcttgtgt attctgttac atcaatcaaa agttttgaag 300 tgattaaagt tatccatggc aaattgttgg atatggtggg gaaagtacaa atacctatta 360 tgttggtttg gaataagaaa gacctgcata tggaaagggt gatcagttat gaagaaggga 420 aagctttggc agaatcttgg aatgcagctt ttttggaatc ttctgctaaa gaaaatcaga 480 ctgctgtgga tgtttttcga aggataattt tggaggcaga aaaaatggac ggggcagctt 540 cacaaggcaa gtcttcatgc tcggtgatgt gattctgctg caaagcctga ggacactggg 600 aatatattct acctgaagaa gcaaactgcc cgttctcctt gaagataaac tatgcttctt 660 ttttcttctg ttaacctgaa agatatcatt tgggtcagag ctcccctccc ttcagattat 720 gttaactctg agtctgtcca aatgagttca cttccatttt caaattttaa gcaatcatat 780 tttcaattta tatattgtat ttcttaatat tatgaccaag aattttatcg gcattaattt 840 ttcagtgtag tttgttgttt aaaataatgt aatcatcaaa atgatgcata ttgttacact 900 actattaact aggcttcagt atatcagtgt ttatttcatt gtgttaaatg tatacttgta 960 aataaaatag ctgcaaacct c 981 <210> 74 <211> 2263 <212> DNA <213> Homo sapiens <220> <223> Genbank Accession No. U03985 <400> 74 gagccggacg tgtgcgcgaa gatggcgggc cggagcatgc aagcggcaag atgtcctaca 60 gatgaattat ctttaaccaa ttgttcagtt gtgaatgaaa aggatttcca gtctggccag 120 catgtgattg tgaggacctc tcccaatcac aggtacacat ttacactgaa gacacatcca 180 tcggtggttc cagggagcat tgcattcagt ttacctcaga gaaaatgggc tgggctttct 240 attgggcaag aaatagaagt ctccttatat acatttgaca aagccaaaca gtgtattggc 300 acaatgacca tcgagattga tttcctgcag aaaaaaagca atgactccaa cccttatgac 360 accgacaaga tggcagcaga atttattcag caattcaaca accaggccta ctcagtggga 420 caacagcttg tctttagctt caatgaaaag ctttttggct tactggtgaa ggacattgaa 480 tccatggatc ctagcatcct gaagggagag cctgcgacag ggaaaaggca gaagattgaa 540 gtaggactgg ttgttggaaa cagtcaagtt gcatttgaaa aagcagaaaa ttcgtcactt 600 aatcttattg gcaaagctaa aaccaaggaa aatcgccaat caattatcaa tcctgactgg 660 aactttgaaa aaatgggaat aggaggtcta gacaaggaat tttcagatat tttccgacga 720 gcatttgcct tccgagtatt tcctccagag attgtggagc agatgggttg tatacatgtt 780 aaaggcatcc tgttatatgg acccccaggt tgtggtaaga ctctcttggc tcgacagatt 840 ggcaagatgt tgaatgcaag agagcccaaa gtggtcaatg ggccagaaat ccttaacaaa 900 tatgtgggag aatcagaggc taacattcgc aaactttttg ctgatgctga agaggagcaa 960 aggaggcttg gtgctaacag tggtttgcac atcatcatct ttgatgaaat tgatgccatc 1020 tgcaagcaga gagggagcat ggctggtagc acgggagttc atgacactgt tgtcaaccag 1080 ttgctgtcca aaattgatgg cgtggagcag ctaaacaaca tcctagtcat tggaatgacc 1140 aatagaccag atctgataga tgaggctctt cttagacctg gaagactgga agttaaaatg 1200 gagataggct tgccagatga gaaaggccga ctacagattc ttcacatcca cacagcaaga 1260 atgagagggc atcagttact ctctgctgat gtagacatta aagaactggc cgtggagacc 1320 aagaatttca gtggtgctga attggagggt ctggtgcgag cagcccagtc cactgctatg 1380 aatagacaca taaaggccag tactaaagtg gaagtggaca tggagaaagc agaaagcctg 1440 caagtgacga gaggagactt ccttgcttct ttggagaatg atatcaaacc agcctttggc 1500 acaaaccaag aagattatgc aagttacatt atgaacggta tcatcaaatg gggtgaccca 1560 gttactcgag ttctagatga tggggagctg ctggtgcagc agactaagaa cagtgaccgc 1620 acaccattgg tcagcgtgct tctggaaggc cctcctcaca gtgggaagac tgctttagct 1680 gcaaaaattg cagaggaatc caacttcccg ttcatcaaga tctgttctcc tgataaaatg 1740 attggctttt ctgaaacagc caaatgtcag gccatgaaga agatctttga tgatgcgtac 1800 aaatcccagc tcagttgtgt ggttgtggat gacattgaga gattgcttga ttacgtccct 1860 attggccctc gattttcaaa tcttgtatta caggctcttc tcgttttact gaaaaaggca 1920 cctcctcagg gccgcaagct tcttatcatt gggaccacta gccgcaaaga tgtccttcag 1980 gagatggaaa tgcttaacgc tttcagcacc accatccacg tgcccaacat tgccacagga 2040 gagcagctgt tggaagcttt ggagcttttg ggcaacttaa aggataagga acgcaccaca 2100 attgcacagc aagtcaaagg gaagaaggtc tggataggaa tcaagaagtt actaatgctg 2160 atcgagatgt ccctacagat ggatcctgaa taccgtgtga gaaaattctt ggccctctta 2220 agagaagaag gagctagccc ccttgatttt gattgaaaat gaa 2263 <210> 75 <211> 1476 <212> DNA <213> Homo sapiens <220> <223> Genbank Accession No. U16799 <400> 75 gccacccacc ctccggaccg cggcagctgc tgacccgcca tcgccatggc ccgcgggaaa 60 gccaaggagg agggcagctg gaagaaattc atctggaact cagagaagaa ggagtttctg 120 ggcaggaccg gtggcagttg gtttaagatc cttctattct acgtaatatt ttatggctgc 180 ctggctggca tcttcatcgg aaccatccaa gtgatgctgc tcaccatcag tgaatttaag 240 cccacatatc aggaccgagt ggccccgcca ggattaacac agattcctca gatccagaag 300 actgaaattt cctttcgtcc taatgatccc aagagctatg aggcatatgt actgaacata 360 gttaggttcc tggaaaagta caaagattca gcccagaggg atgacatgat ttttgaagat 420 tgtggcgatg tgcccagtga accgaaagaa cgaggagact ttaatcatga acgaggagag 480 cgaaaggtct gcagattcaa gcttgaatgg ctgggaaatt gctctggatt aaatgatgaa 540 acttatggct acaaagaggg caaaccgtgc attattataa agctcaaccg agttctaggc 600 ttcaaaccta agcctcccaa gaatgagtcc ttggagactt acccagtgat gaagtataac 660 ccaaatgtcc ttcccgttca gtgcactggc aagcgagatg aagataagga taaagttgga 720 aatgtggagt attttggact gggcaactcc cctggttttc ctctgcagta ttatccgtac 780 tatggcaaac tcctgcagcc caaatacctg cagcccctgc tggccgtaca gttcaccaat 840 cttaccatgg acactgaaat tcgcatagag tgtaaggcgt acggtgagaa cattgggtac 900 agtgagaaag accgttttca gggacgtttt gatgtaaaaa ttaaatttta agtgacacta 960 cagaaaaaca caaaaaggtg atgggttgtg ttatgcttgt attgaatgct gtcttgacat 1020 ctcttgcctt gtcctccggt atgttctaaa gctgtgtctg agatctggat ctgcccatca 1080 ctttggctag tgacagggct aattaatttg ctttatacat tttcttttac tttccttttt 1140 tcctttctgg aggcatcaca tgctggtgct gtgtctttat gaatgtttta accattttca 1200 tggtggaaga attttatatt tatgcagttg tacaatttta tttttttctg caagaaaaag 1260 tgtaatgtat gaaataaacc aaagtcactt gtttgaaaat aaatctttat tttgaacttt 1320 ataaaaagca atgcagtacc ccatagactg gtgttaaatg ttgtctacag tgcaaaatcc 1380 atgttctaac atatgtaata attgccagga gtacagtgct cttgttgatc ttgtattcag 1440 tcaggttaaa acaacggtca ataaaagaat gaacac 1476 <210> 76 <211> 825 <212> DNA <213> Homo sapiens <220> <223> Genbank Accession No. AI354351 <400> 76 tgaagttcat catctttaga cttaaggaat taacaagggt cagggagact acaccaggct 60 gagggcttct tggttcctgg agacatgccc agctacagca aacacaggga aacacgaagg 120 gggcagctgg aagatttggt cttgaacttg gggggtgggt aagtgatgat ccccacgact 180 ggagcagcag gaagaagttg tgtctgagga agtgctgggc cgcccagagg gacagccctg 240 ccctggagct tgtcgccggg agggaaggga aacaagcccc ctccctcagt gctgaggaaa 300 aggcacttgg cctgggtctc ctcctgccct ctccccatcc gtgggagaga cggggtcctt 360 gcctccttgc ccctttcagc cgcccagaag ccggtcctgg ttcagcctct ggaagaagct 420 tttgccgaac tcataggtgc tgatcatgat ggcacaggag ggggcagcct tgatgatccg 480 aggaaggaag cctgcaaaga gtcccttgtt gcccgactcg gaccggatcc ttcgcagcag 540 cagccaggtg gagtccacat gccaggagtt cacttttcca gcctccatcg ctccccagac 600 gacctggccg ttggtcttta ccacgtcaaa gggtagaagt aagaactgcg cccaccgccc 660 tgagatgcca ccagcccaca aagctcaggc ccacagaagt cttgttcttt cggctgagcc 720 cattgaccca gtttttcacc agctctaggt taacccagaa cgggcttgaa aagccacatt 780 tccgaaggcc agtggggcct agcccagcca cagggaacgc cagcc 825 <210> 77 <211> 692 <212> DNA <213> Homo sapiens <220> <223> Genbank Accession No. D26598 <400> 77 cctagtacac cgcaatcatg tctattatgt cctataacgg aggggccgtc atggccatga 60 aggggaagaa ctgtgtggcc atcgctgcag acaggcgctt cgggatccag gcccagttgg 120 tgaccacgga cttccagaag atctttccca tgggtgaccg gctgtacatc ggtctggccg 180 ggctcgccac tgacgtccag acagttgccc agcgcctcaa gttccggctg aacctgtatg 240 agttgaagga aggtcggcag atcaaacctt ataccctcat gagcatggtg gccaacctct 300 tgtatgagaa acggtttggc ccttactaca ctgagccagt cattgccggg ttggacccga 360 agacctttaa gcccttcatt tgctctctag acctcatcgg ctgccccatg gtgactgatg 420 actttgtggt cagtggcacc tgcgccgaac aaatgtacgg aatgtgtgag tccctctggg 480 agcccaacat ggatccggat cacctgtttg aaaccatctc ccaagccatg ctgaatgctg 540 tggaccggga tgcagtgtca ggcatgggag tcattgtcca catcatcgag aaggacaaaa 600 tcaccaccag gacactgaag gcccgaatgg actaaccctg ttcccagagc ccactttttt 660 ttcttttttt gaaataaaat agcctgtctt tc 692 <210> 78 <211> 1059 <212> DNA <213> Homo sapiens <220> <223> Genbank Accession No. X95404 <400> 78 gctctcgtct tctgcggctc tcggtgccct ctccttttcg tttccggaaa catggcctcc 60 ggtgtggctg tctctgatgg tgtcatcaag gtgttcaacg acatgaaggt gcgtaagtct 120 tcaacgccag aggaggtgaa gaagcgcaag aaggcggtgc tcttctgcct gagtgaggac 180 aagaagaaca tcatcctgga ggagggcaag gagatcctgg tgggcgatgt gggccagact 240 gtcgacgatc cctacgccac ctttgtcaag atgctgccag ataaggactg ccgctatgcc 300 ctctatgatg caacctatga gaccaaggag agcaagaagg aggatctggt gtttatcttc 360 tgggcccccg agtctgcgcc ccttaagagc aaaatgattt atgccagctc caaggacgcc 420 atcaagaaga agctgacagg gatcaagcat gaattgcaag caaactgcta cgaggaggtc 480 aaggaccgct gcaccctggc agagaagctg gggggcagtg cggtcatctc cctggagggc 540 aagcctttgt gagccccttc tggccccctg cctggagcat ctggcagccc cacacctgcc 600 cttgggggtt gcaggctgcc cccttcctgc cagaccggag gggctggggg gatcccagca 660 gggggaggca atcccttcac cccagttgcc aaacagaccc cccaccccct ggattttcct 720 tctccctcca tcccttgacg gttctggcct tcccaaactg cttttgatct tttgattcct 780 cttgggctga agcagaccaa gttcccccca ggcaccccag ttgtggggga gcctgtattt 840 tttttaacaa catccccatt ccccacctgg tcctccccct tcccatgctg ccaacttcta 900 accgcaatag tgactctgtg cttgtctgtt tagttctgtg tataaatgga atgttgtgga 960 gatgacccct ccctgtgccg gctggttcct ctcccttttc ccctggtcac ggctactcat 1020 ggaagcagga ccagtaaggg accttcgatt aaaaaaaaa 1059 <210> 79 <211> 3309 <212> DNA <213> Homo sapiens <220> <223> Genbank Accession No. M15036 <400> 79 ctgcaggggg gggggggggg gggggggggg ggggggggcg cagcacggct cagaccgagg 60 cgcacaggct cgcagctccg ggcgcctagc gcccggtccc cgccgcgacg cgccaccgtc 120 cctgccggcg cctccgcgcc ttcgaaatga gggtcctggg tgggcgctgc ggggcgccgc 180 tggcgtgtct cctcctagtg cttcccgtct cagaggcaaa ccttctgtca aagcaacagg 240 cttcacaagt cctggttagg aagcgtcgtg caaattcttt acttgaagaa accaaacagg 300 gtaatcttga aagagaatgc atcgaagaac tgtgcaataa agaagaagcc agggaggtct 360 ttgaaaatga cccggaaacg gattattttt atccaaaata cttagtttgt cttcgctctt 420 ttcaaactgg gttattcact gctgcacgtc agtcaactaa tgcttatcct gacctaagaa 480 gctgtgtcaa tgccattcca gaccagtgta gtcctctgcc atgcaatgaa gatggatata 540 tgagctgcaa agatggaaaa gcttctttta cttgcacttg taaaccaggt tggcaaggag 600 aaaagtgtga atttgacata aatgaatgca aagatccctc aaatataaat ggaggttgca 660 gtcaaatttg tgataataca cctggaagtt accactgttc ctgtaaaaat ggttttgtta 720 tgctttcaaa taagaaagat tgtaaagatg tggatgaatg ctctttgaag ccaagcattt 780 gtggcacagc tgtgtgcaag aacatcccag gagattttga atgtgaatgc cccgaaggct 840 acagatataa tctcaaatca aagtcttgtg aagatataga tgaatgctct gagaacatgt 900 gtgctcagct ttgtgtcaat taccctggag gttacacttg ctattgtgat gggaagaaag 960 gattcaaact tgcccaagat cagaagagtt gtgaggttgt ttcagtgtgc cttcccttga 1020 accttgacac aaagtatgaa ttactttact tggcggagca gtttgcaggg gttgttttat 1080 atttaaaatt tcgtttgcca gaaatcagca gattttcagc agaatttgat ttccggacat 1140 atgattcaga aggcgtgata ctgtacgcag aatctatcga tcactcagcg tggctcctga 1200 ttgcacttcg tggtggaaag attgaagttc agcttaagaa tgaacataca tccaaaatca 1260 caactggagg tgatgttatt aataatggtc tatggaatat ggtgtctgtg gaagaattag 1320 aacatagtat tagcattaaa atagctaaag aagctgtgat ggatataaat aaacctggac 1380 ccctttttaa gccggaaaat ggattgctgg aaaccaaagt atactttgca ggattccctc 1440 ggaaagtgga aagtgaactc attaaaccga ttaaccctcg tctagatgga tgtatacgaa 1500 gctggaattt gatgaagcaa ggagcttctg gaataaagga aattattcaa gaaaaacaaa 1560 ataagcattg cctggttact gtggagaagg gctcctacta tcctggttct ggaattgctc 1620 aatttcacat agattataat aatgtatcca gtgctgaggg ttggcatgta aatgtgacct 1680 tgaatattcg tccatccacg ggcactggtg ttatgcttgc cttggtttct ggtaacaaca 1740 cagtgccctt tgctgtgtcc ttggtggact ccacctctga aaaatcacag gatattctgt 1800 tatctgttga aaatactgta atatatcgga tacaggccct aagtctatgt tccgatcaac 1860 aatctcatct ggaatttaga gtcaacagaa acaatctgga gttgtcgaca ccacttaaaa 1920 tagaaaccat ctcccatgaa gaccttcaaa gacaacttgc cgtcttggac aaagcaatga 1980 aagcaaaagt ggccacatac ctgggtggcc ttccagatgt tccattcagt gccacaccag 2040 tgaatgcctt ttataatggc tgcatggaag tgaatattaa tggtgtacag ttggatctgg 2100 atgaagccat ttctaaacat aatgatatta gagctcactc atgtccatca gtttggaaaa 2160 agacaaagaa ttcttaaggc atcttttctc tgcttataat accttttcct tgtgtgtaat 2220 tatacttatg tttcaataac agctgaaggg ttttatttac aatgtgcagt ctttgattat 2280 tttgtggtcc tttcctggga tttttaaaag gtcctttgtc aaggaaaaaa attctgttgt 2340 gatataaatc acagtaaaga aattcttact tctcttgcta tctaagaata gtgaaaaata 2400 acaattttaa atttgaattt ttttcctaca aatgacagtt tcaatttttg tttgtaaaac 2460 taaattttaa ttttatcatc atgaactagt gtctaaatac ctatgttttt ttcagaaagc 2520 aaggaagtaa actcaaacaa aagtgcgtgt aattaaatac tattaatcat aggcagatac 2580 tattttgttt atgtttttgt ttttttcctg atgaaggcag aagagatggt ggtctattaa 2640 atatgaattg aatggagggt cctaatgcct tatttcaaaa caattcctca gggggaccag 2700 ctttggcttc atctttctct tgtgtggctt cacatttaaa ccagtatctt tattgaatta 2760 gaaaacaagt gggacatatt ttcctgagag cagcacagga atcttcttct tggcagctgc 2820 agtctgtcag gatgagatat cagattaggt tggataggtg gggaaatctg aagtgggtac 2880 attttttaaa ttttgctgtg tgggtcacac aaggtctaca ttacaaaaga cagaattcag 2940 ggatggaaag gagaatgaac aaatgtggga gttcatagtt ttccttgaat ccaactttta 3000 attaccagag taagttgcca aaatgtgatt gttgaagtac aaaaggaact atgaaaacca 3060 gaacaaattt taacaaaagg acaaccacag agggatatag tgaatatcgt atcattgtaa 3120 tcaaagaagt aaggaggtaa gattgccacg tgcctgctgg tactgtgatg catttcaagt 3180 ggcagtttta tcacgtttga atctaccatt catagccaga tgtgtatcag atgtttcact 3240 gacagttttt aacaataaat tcttttcact gtattttata tcacttataa taaatcggtg 3300 tataatttt 3309 <210> 80 <211> 604 <212> DNA <213> Homo sapiens <220> <223> Genbank Accession No. AA219354 <220> <221> unsure <222> (1)..(604) <223> n = a or c or g or t <400> 80 gaatacaatg atgtatttct ttattttcac atacactcta gctaaaagag caagagtaca 60 catcaacaaa aatggaaaca aggctttggc tgaaaaaaac atgcatttga caaatcatgt 120 taatagctag acaagaagaa agttagcttt gtaaacttct acttcatttg attcagagaa 180 acagagcatg agttttctta aaagtaacaa gaaaaggaac aaaaaaaatg aggtttgaaa 240 tcttttacca tggcaaaaca ttaacatctt tctcaaaaac atagagaaat ctggaaaaat 300 caagaagata aaattctgga ccagttagtg acattctttc aagcatactt gtaaaatgtt 360 tccttaaagt gttcttggga tgaaaatgat tgtcatgtct ccaacaacag tgaactgatg 420 ttgttccttg gaataaaagt caatccccac cttaaaaaat gtatggcttc tttgaggaat 480 tcttatggct taaagacttt ttacattcta gaccattaaa ttgattgagg nctaaattaa 540 gaagtgaata gttacnctac acggtaaggt agcagcctga agcattggna ccaanagggt 600 gtgg 604 <210> 81 <211> 1550 <212> DNA <213> Homo sapiens <220> <223> Genbank Accession No. M16447 <400> 81 gtggcctacc atggtttcaa cgggtaacgg ggaataaggg ttcgattcgg agctgcggga 60 gccgggctgg caggagcagg atggcggcgg cggcggctgc aggcgaggcg cgccgggtgc 120 tggtgtacgg cggcaggggc gctctgggtt ctcgatgcgt gcaggctttt cgggcccgca 180 actggtgggt tgccagcgtt gatgtggtgg agaatgaaga ggccagcgct acgatcattg 240 ttaaaatgac agactcgttc actgagcagg ctgaccaggt gactgctgag gttggaaagc 300 tcttgggtga agagaaggtg gatgcaattc tttgcgttgc tggaggatgg gccgggggca 360 atgccaaatc caagtctctc tttaagaact gtgacctgat gtggaagcag agcatatgga 420 catcgaccat ctccagccat ctggctacca agcatctcaa ggaaggaggc ctcctgacct 480 tggctggcgc aaaggctgcc ctggatggga ctcctggtat gatcgggtac ggcatggcca 540 agggtgctgt tcaccagctc tgccagagcc tggctgggaa gaacagcggc atgccgcccg 600 gggcagccgc catcgctgtg ctcccggtta ccctggatac cccgatgaac aggaaatcaa 660 tgcctgaggc tgacttcagc tcctggacac ccttagaatt cctagttgaa actttccatg 720 actggatcac agggaaaaac cgaccgagct caggaagcct aatccaggtg gtaaccacag 780 aaggaaggac ggaactcacc ccagcatatt tttaggcctc atctcagtgc ctatgagggg 840 cctgccagaa aagtcactaa cctgtctcag tgtggccttg tccagccttg tgttttctgt 900 aacccctgtt tgtggtacga gataatgagt cctatttttc tctcacataa tatgcatttg 960 ctctcctagg gacaagtgta atacatttat gtgaagtaag acaatgcgag actggtggcc 1020 gtcaaatagc atccgtcaat ctgtgttaac tgcataggag gctctcgata gcacctgcta 1080 tagcggtgtc atgttggatc gctttgtgac tgttcatctg tccttgacag tggctgtcat 1140 cttgactact ttgttgattt gttggtattg gggacatttt aaaggctgag ttatttttga 1200 atgtcatgtt tatgtcatag acgtagaaaa cgcatccttg aattaaactg ccttaactcc 1260 ttttgtggta taagcaaact acatggactc tgtccctggt atccttttcc tgtgtggttg 1320 cccctgtgcc tgtggtctgg cctaggttaa gtgtgcaaga taactactcg tgagttattc 1380 agaatgttgt tcctaataaa tgcacttgtt gtctgtcttc tttaatcaaa tcacatctta 1440 tatacagcag tcagagatga gtatactaga atcatggatt gctggaggtc ttttaatctg 1500 atgttctcag aagggggtgg atttaaatcc tgaaataaat atttcaacac 1550 <210> 82 <211> 3634 <212> DNA <213> Homo sapiens <220> <223> Genbank Accession No. D10040 <400> 82 tcaacacagg acaatgcaag cccatgagct gttccggtat tttcgaatgc cagagctggt 60 tgacttccga cagtacgtgc gtactcttcc gaccaacacg cttatgggct tcggagcttt 120 tgcagcactc accaccttct ggtacgccac gagacccaaa cccctgaagc cgccatgcga 180 cctctccatg cagtcagtgg aagtggcggg tagtggtggt gcacgaagat ccgcactact 240 tgacagcgac gagcccttgg tgtatttcta tgatgatgtc acaacattat acgaaggttt 300 ccagagggga atacaggtgt caaataatgg cccttgttta ggctctcgga aaccagacca 360 accctatgaa tggctttcat ataaacaggt tgcagaattg tcggagtgca taggctcagc 420 actgatccag aagggcttca agactgcccc agatcagttc attggcatct ttgctcaaaa 480 tagacctgag tgggtgatta ttgaacaagg atgctttgct tattcgatgg tgatcgttcc 540 actttatgat acccttggaa atgaagccat cacgtacata gtcaacaaag ctgaactctc 600 tctggttttt gttgacaagc cagagaaggc caaactctta ttagagggtg tagaaaataa 660 gttaatacca ggccttaaaa tcatagttgt catggatgcc tacggcagtg aactggtgga 720 acgaggccag aggtgtgggg tggaagtcac cagcatgaag gcgatggagg acctgggaag 780 agccaacaga cggaagccca agcctccagc acctgaagat cttgcagtaa tttgtttcac 840 aagtggaact acaggcaacc ccaaaggagc aatggtcact caccgaaaca tagtgagcga 900 ttgttcagct tttgtgaaag caacagagaa tacagtcaat ccttgcccag atgatacttt 960 gatatctttc ttgcctctcg cccatatgtt tgagagagtt gtagagtgtg taatgctgtg 1020 tcatggagct aaaatcggat ttttccaagg agatatcagg ctgctcatgg atgacctcaa 1080 ggtgcttcaa cccactgtct tccccgtggt tccaagactg ctgaaccgga tgtttgaccg 1140 aattttcgga caagcaaaca ccacgctgaa gcgatggctc ttggactttg cctccaagag 1200 gaaagaagca gagcttcgca gcggcatcat cagaaacaac agcctgtggg accggctgat 1260 cttccacaaa gtacagtcga gcctgggcgg aagagtccgg ctgatggtga caggagccgc 1320 cccggtgtct gccactgtgc tgacgttcct cagagcagcc ctgggctgtc agttttatga 1380 aggatacgga cagacagagt gcactgccgg gtgctgccta accatgcctg gagactggac 1440 cgcaggccat gttggggccc cgatgccgtg caatttgata aaacttgttg atgtggaaga 1500 aatgaattac atggctgccg agggcgaggg cgaggtgtgt gtgaaagggc caaatgtatt 1560 tcagggctac ttgaaggacc cagcgaaaac agcagaagct ttggacaaag acggctggtt 1620 acacacaggg gacattggaa aatggttacc aaatggcacc ttgaaaatta tcgaccggaa 1680 aaagcacata tttaagctgg cacaaggaga atacatagcc cctgaaaaga ttgaaaatat 1740 ctacatgcga agtgagcctg ttgctcaggt gtttgtccac ggagaaagcc tgcaggcatt 1800 tctcattgca attgtggtac cagatgttga gacattatgt tcctgggccc aaaagagagg 1860 atttgaaggg tcgtttgagg aactgtgcag aaataaggat gtcaaaaaag ctatcctcga 1920 agatatggtg agacttggga aggattctgg tctgaaacca tttgaacagg tcaaaggcat 1980 cacattgcac cctgaattat tttctatcga caatggcctt ctgactccaa caatgaaggc 2040 gaaaaggcca gagctgcgga actatttcag gtcgcagata gatgacctct attccactat 2100 caaggtttag tgtgaagaag aaagctcaga ggaaatggca cagttccaca atctcttctc 2160 ctgctgatgg ccttcatgtt gttaattttg aatacagcaa gtgtagggaa ggaagcgttc 2220 gtgtttgact tgtccattcg gggttcttct cataggaatg ctagaggaaa cagaacaccg 2280 ccttacagtc acctcatgtt gcagaccatg tttatggtaa tacacacttt ccaaaatgag 2340 ccttaaaaat tgtaaagggg atactataaa tgtgctaagt tatttgagac ttcctcagtt 2400 taaaaagtgg gttttaaatc ttctgtctcc ctgcttttct aatcaagggg ttaggacttt 2460 gctatctctg agatgtctgc tacttgctgc aaattctgca gctgtctgct gctctaaaga 2520 gtacagtgca ctagagggaa gtgttccctt taaaaataag aacaactgtc ctggctggag 2580 aatctcacaa gcggaccaga gatcttttta aatccctgct actgtccctt ctcacaggca 2640 ttcacagaac ccttctgatt cgtaagggtt acgaaactca tgttcttctc cagtcccctg 2700 tggtttctgt tggagcataa ggtttccagt aagcgggagg gcagatccaa ctcagaacca 2760 tgcagataag gagcctctgg caaatgggtg ctcatcagaa cgcgtggatt ctctttcatg 2820 gcagaatgct cttggactcg gttctccagg cctgattccc cgactccatc ctttttcagg 2880 ggttatttaa aaatctgcct tagattctat agtgaagaca agcatttcaa gaaagagtta 2940 cctggatcag ccatgctcag ctgtgacgcc tgaataactg tctactttat cttcactgaa 3000 ccactcactc tgtgtaaagg ccaacagatt tttaatgtgg ttttcatatc aaaagatcat 3060 gttgggatta acttgccttt ttccccaaaa aataaactct caggcaagca tttctttaaa 3120 gctattaagg gagtatatac ttgagtactt attgaaatgg acagtaataa gcaaatgttc 3180 ttataatgct acctgatttc tatgaaatgt gtttgacaag ccaaaattct aggatgtaga 3240 aatctggaaa gttcatttcc tgggattcac ttctccaggg attttttaaa gttaatttgg 3300 gaaattaaca gcagttcact ttattgtgag tctttgccac atttgactga attgagctgt 3360 catttgtaca tttaaagcag ctgttttggg gtctgtgaga gtacatgtat tatatacaag 3420 cacaacaggg cttgcactaa agaattgtca ttgtaataac actacttggt agcctaactt 3480 catatatgta ttcttaattg cacaaaaagt caataatttg tcaccttggg gttttgaatg 3540 tttgctttaa gtgttggcta tttctatgtt ttataaacca aaacaaaatt tccaaaaaca 3600 atgaaggaaa ccaaaataaa tatttctgca tttc 3634 <210> 83 <211> 377 <212> DNA <213> Homo sapiens <220> <223> Genbank Accession No. W42636 <400> 83 cactatgtac aaaaacattt taattgaaat acctgtataa aaaaatatga tctccagaca 60 tctcactttt gaactgaaag aacccccatc tgcgatgcct gcacacaccg cattcacaca 120 aacacaggta ctgaataaat taaacgctca ggctctggcc ccaccccagc tttcagagcc 180 cacaagcaga ctgtacaaag tcaataattt aaaacccaaa ccctgggcac agtgcctgga 240 agtgtcaggg tcacccactc cccttaagtt agccactata catgttcatc ttctgacagg 300 cggggccagg acagacgcca ggcacaggga atcaggggct gggggtccct tggaccacag 360 gccaaccccc tcccctt 377 <210> 84 <211> 418 <212> DNA <213> Homo sapiens <220> <223> Genbank Accession No. T66157 <220> <221> unsure <222> (1)..(418) <223> n = a or c or g or t <400> 84 tttttagaaa gaaatagatt tattctcatg tacaaagcgg tcacccacgg gaccatatac 60 gacagttgca cagagtccta gaaaaacgca tctntctaaa ggcaactcag aaaggtaagg 120 caggtggacc ccctccccca ccccacaacg cacacagant gaaacggaga aaaagagaga 180 agccagtgnc ngggntgacc caagattccc ggccctatgg ggtttcccaa gccccagggc 240 acaggtggnt atggccttna agagagagcc ctgccaggtt nanggccagg tttttcattg 300 gctgcaggnt tgggtaaggg gntcaggcca aggggaacan tcagggggcc tntnagacan 360 tcaggnttgg gntctctgtg ccttaggggt ttgcagaaac attccatagc ctctgctg 418 <210> 85 <211> 1811 <212> DNA <213> Homo sapiens <220> <223> Genbank Accession No. M62831 <400> 85 ggtttgtgta gagaggcgtg cagagcccgt tgtccggagt gcacctgctg cctgttctgt 60 ccctcccggg agcccccgcc gctgtcgccg tcgagtcgcc atggaagtgc agaaagaggc 120 acagcgcatc atgaccctgt cggtgtggaa gatgtatcac tcccgcatgc agcgcggtgg 180 cctgcggctg caccggagtc tgcagctgtc gctggtcatg cgcagcgccc gggagctcta 240 cctctcggcc aaggtggagg ccctcgagcc cgaggtgtcg ttgccggccg ccctcccctc 300 tgaccctcgc ctgcacccgc cccgagaagc cgagtccacg gccgagacag cgacccccga 360 cggtgagcac ccgtttccgg agccaatgga cacgcaggag gcgccgacag ccgaggagac 420 ctccgcctgc tgtgccccgc gccccgccaa agtcagccgc aaacgacgca gcagcagcct 480 gagcgacggc ggggacgttg gactggtccc gagcaagaaa gcccgtctgg aagaaaagga 540 agaagaggag ggagcgtcat ccgaagtcgc cgatcgcctg cagccccctc cgggccaagc 600 ggagggcgcc tttcccaacc tggcccgcgt cctgcagagg cgcttctccg gcctcctgaa 660 ctgcagcccc gcggcccctc cgacggcgcc gcccgcgtgc gaggcaaagc ccgcttgccg 720 cccggcggac agcatgctca acgtgctcgt gcgggccgtg gtggccttct gaggaccccg 780 agcggcgctg ccggagccca gagcgcgcgt cgaaccgtcg gcccgagggc gcagacctga 840 ggcgaggcca cccccctcca tcctggggga agcgcccgcg aaaaccgtgg agagaagccg 900 ccgcccgggc tgctgagagg cccggagagg actctgtccc cggggagcca tcgccttcag 960 tgtgcaggga cggcaccgag gagtctgagc cgggcgcggg cgccttccgc agagacctgc 1020 gcccacaggt gctgtcttag tggactggga cgtgaacctt tcgctctcct tctggactgg 1080 gagaagggag gcttgggtgt tgtgtttttt gttttgtttg tttgtttgtt tttaaagatc 1140 tcctcagggt cggacttcat tttgtactgt gggctgtgct ggccctttca aggtttttca 1200 agagttggtt ttgcgtttcc aacctcggag aattccaggc actccccttc cccctccgct 1260 gacatacttg tataagcggt catcgttgcg tcatggggca ggcgtgggga gcttcctgtc 1320 gccttggctg ggtgtgggcc tggaggaagg tcctggggcg tgcactcgcc tgggcagtgg 1380 ggaggagagt ggcctgagtt acttcacccc cgcgtgctgc tggttaatgt cccgcgtctc 1440 tgcaccttcg ggtgggagcg gggactgatc tactttcaca ttctcaagtt tttctcatct 1500 gcattagagg tccccagtag gttcccaggt tccagcgtgc ccctccctca gacacacgga 1560 cacaatcagc cgagaagttc ctggtctgaa tcacgagaat gtggaggggt ggggggtgtc 1620 agtggaaagg cataaggctg agctgagacc agttgctggt gaaactgggc caatctgggg 1680 aggggaacat ccttgccagg gagtttctga gggtctgctt tgtttacctt tcgtgcggtg 1740 gattcttttt aactccgtct acctggcgtt ttgttagaaa tgtcagatag gaaaataaaa 1800 accatttgag t 1811 <210> 86 <211> 372 <212> DNA <213> Homo sapiens <220> <223> Genbank Accession No. T98839 <220> <221> unsure <222> (1)..(372) <223> n = a or c or g or t <400> 86 gattcaaaag aatggagatg gagaagaagg ggaggggagg gaggggagag ataaacagag 60 agagacagag aattatatag cagtatgcaa aaaaccagtt taaaacctgt gaagcaaaga 120 gaaatgggtg tatgagctag acaggcatga ggagtgacag agtttcctct tcaaggagac 180 ggtatccctt ctgttgacat acacaggtga tccagaactn ccgtgagtgt ccttcccgac 240 gagatttccc tctggggtga attttgtgcg gggtggccct caaagctcct ctctaccacc 300 cgtgaggacc ctccccaaag actttttatt ctttttaaag tcttgggaaa agccctgctt 360 ttcctccttt ta 372 <210> 87 <211> 924 <212> DNA <213> Homo sapiens <220> <223> Genbank Accession No. U41344 <400> 87 agttcagaga gaagtctaca gtccttgtct cggggtgtct tcccccttcc ccttcctcat 60 cttccccgcc agcctccact cccttctgat ttctcgtctt ctttttccgt agaaatcaac 120 ggaacccaga tttgccccaa cgacctagtg gcgttccatg acttctcctc ggacctggag 180 aacgtgccac acctgcgcta cctgcggctg gatggaaact acttgaagcc gcccatcccg 240 ctggacctca tgatgtgctt ccgcctcctg cagtccgtgg tcatctaggc cctactccgc 300 caccggatct gctctgaccg cacttgaagg ctggggccca ggacctgtgc cggccattcg 360 ttttctctct ctccctttct ttctcccagc tttgcctcct tatgccacct cgaggcaggg 420 aaaagccatc tatacttctg cagcctaagg agcgagactt caaggactca gtttggttcc 480 acccagttga aagacaccca gtgcacaccc aaactcctgg ccttctgtgg tttccctttg 540 ctccagaaac acagatgtgt ctaaagactt ggtgtcccct tctctctcct cccccacccg 600 ccactcctgg gtacatctgg gccgtggact atctgatctt ggtcctggcc gagaaacagc 660 ccggagtaag gttcagaaag tccccctggg gactcctcca tcttcggcag ctctggctca 720 aagaggccga gaaacccagt tctcctgggc caaggatccc ttctggcaaa gctgctgctc 780 cgccgcttgg ttccccggca ccagacatcg ccctggccct gctggcccgg gtatcggaag 840 gaggagcgag ggaatgacgg aggtagggtg cagggtaagg gctcccaggt cttcatctgg 900 ccagcaggac acagggatct aagg 924 <210> 88 <211> 511 <212> DNA <213> Homo sapiens <220> <223> Genbank Accession No. AI765890 <400> 88 tgcttttgaa ttattgattt attgcacatc aggagaaaca caagattact gctataataa 60 attcactctt acatgcttta gcaaaaatca gtaaaaatag aaaacatggt aacaattaaa 120 gtgaaaaaat tggggtcatt aaagaatgtc tgactgatta gcttgcagtt tttgagacgg 180 ctgagaacta ccatcaatga gatcacctta aacaaacact cttaatgact tgaaaaagtc 240 cccatcccaa agtcaactat aggtattcaa tattgtatat ttaactgaat ttaaagttat 300 gttaaaaccc attttattga agtaagagaa gaattccttt tacattatca ttctcaagcc 360 atatatcaag aaaaagattg aaattacatt cctttttttt tttttaatag agacaagttc 420 tcgctgtgtt gcccaggctg gtctcgaact cctaggttca agtgatcctc ctgccttgtc 480 ctgccaaagt gctgggatta caggcatgag c 511 <210> 89 <211> 318 <212> DNA <213> Homo sapiens <220> <223> Genbank Accession No. AL043089 <220> <221> unsure <222> (1)..(318) <223> n = a or c or g or t <400> 89 gtgggttgga gactcagcag gctccgtgca gcccttggga acagtgagag gttgaaggtc 60 ataacgagag tgggaactca acccagatcc cgcccctcct gtcctctgtg ttcccgcgga 120 aaccaaccaa accgtgcgct gtgacccatt gctgttctct gtatcgtgat ctatcctcaa 180 caacaacaga aaaaaggaat aaaatatcct ttgtttccta aaaaaaaaaa aaaaaaaaaa 240 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaggggcgg ccgntntaaa 300 ggatccaagc ttacgtnc 318 <210> 90 <211> 716 <212> DNA <213> Homo sapiens <220> <223> Genbank Accession No. M11433 <400> 90 gggggggggc ggagggcgct catttccggg ccgcccacca cccgcgtagc accggcagcc 60 gctgtcccgg cagtctccag ccgtcccgcc cgcttgtggc caaactggct ccagtcactc 120 ccgaaatgcc agtcgacttc actgggtact ggaagatgtt ggtcaacgag aatttcgagg 180 agtacctgcg cgccctcgac gtcaatgtgg ccttgcgcaa aatcgccaac ttgctgaagc 240 cagacaaaga gatcgtgcag gacggtgacc atatgatcat ccgcacgctg agcactttta 300 ggaactacat catggacttc caagttggga aggagtttga ggaggatctg acaggcatag 360 atgaccgcaa gtgcatgaca acagtgagct gggacggaga caagctccag tgtgtgcaga 420 agggtgagaa ggaggggcgt ggctggaccc agtggatcga gggtgatgag ctgcacctag 480 agatgagagt ggaaggtgtg gtctgcaagc aagtattcaa gaaggtgcag tgaggcccaa 540 gcagacaacc ttgtcccaac caatcagcag gatgtgtgag ccaggatccc tctttgcaca 600 gcatgaggca aaaatgtcca gccaccccta ggcatctgtt agcagagtct gtctcttggc 660 tttgtcactt ttccttttct taaaacaaag ccatgccaat aaagtgacct gtgttc 716 <210> 91 <211> 2052 <212> DNA <213> Homo sapiens <220> <223> Genbank Accession No. Y11307 <400> 91 gcggccgcgt cgacgcgccc ccgagcagcg cccgcgccct ccgcgccttc tccgccggga 60 cctcgagcga aagacgcccg cccgccgccc agccctcgcc tccctgccca ccgggcacac 120 cgcgccgcca ccccgacccc gctgcgcacg gcctgtccgc tgcacaccag cttgttggcg 180 tcttcgtcgc cgcgctcgcc ccgggctact cctgcgcgcc acaatgagct cccgcatcgc 240 cagggcgctc gccttagtcg tcacccttct ccacttgacc aggctggcgc tctccacctg 300 ccccgctgcc tgccactgcc ccctggaggc gcccaagtgc gcgccgggag tcgggctggt 360 ccgggacggc tgcggctgct gtaaggtctg cgccaagcag ctcaacgagg actgcagcaa 420 aacgcagccc tgcgaccaca ccaaggggct ggaatgcaac ttcggcgcca gctccaccgc 480 tctgaagggg atctgcagag ctcagtcaga gggcagaccc tgtgaatata actccagaat 540 ctaccaaaac ggggaaagtt tccagcccaa ctgtaaacat cagtgcacat gtattgatgg 600 cgccgtgggc tgcattcctc tgtgtcccca agaactatct ctccccaact tgggctgtcc 660 caaccctcgg ctggtcaaag ttaccgggca gtgctgcgag gagtgggtct gtgaccagga 720 tagtatcaag gaccccatgg aggaccagga cggcctcctt ggcaaggagc tgggattcga 780 tgcctccgag gtggagttga cgagaaacaa tgaattgatt gcagttggaa aaggcagctc 840 actgaagcgg ctccctgttt ttggaatgga gcctcgcatc ctatacaacc ctttacaagg 900 ccagaaatgt attgttcaaa caacttcatg gtcccagtgc tcaaagacct gtggaactgg 960 tatctccaca cgagttacca atgacaaccc tgagtgccgc cttgtgaaag aaacccggat 1020 ttgtgaggtg cggccttgtg gacagccagt gtacagcagc ctgaaaaagg gcaagaaatg 1080 cagcaagacc aagaaatccc ccgaaccagt caggtttact tacgctggat gtttgagtgt 1140 gaagaaatac cggcccaagt actgcggttc ctgcgtggac ggccgatgct gcacgcccca 1200 gctgaccagg actgtgaaga tgcggttccg ctgcgaagat ggggagacat tttccaagaa 1260 cgtcatgatg atccagtcct gcaaatgcaa ctacaactgc ccgcatgcca atgaagcagc 1320 gtttcccttc tacaggctgt tcaatgacat tcacaaattt agggactaaa tgctacctgg 1380 gtttccaggg cacacctaga caaacaaggg agaagagtgt cagaatcaga atcatggaga 1440 aaatgggcgg gggtggtgtg ggtgatggga ctcattgtag aaaggaagcc ttgctcattc 1500 ttgaggagca ttaaggtatt tcgaaactgc caagggtgct ggtgcggatg gacactaatg 1560 cagccacgat tggagaatac tttgcttcat agtattggag cacatgttac tgcttcattt 1620 tggagcttgt ggagttgatg actttctgtt ttctgtttgt aaattatttg ctaagcatat 1680 tttctctagg cttttttcct ttggggcttc tacagtcgta aaagagataa taagattagt 1740 tggacagttt aaagctttta ttcgtccttt gacaaaagta aatgggaggg cattccatcc 1800 cttcctgaag ggggacactc catgagtgtc tgtgagaggc agctatctgc actctaaact 1860 gcaaacagaa atcaggtgtt ttaagactga atgttttatt tatcaaaatg tagcttttgg 1920 ggagggaggg gaaatgtaat actggaataa tttgtaaatg attttaattt tatattcagt 1980 gaaaagattt tatttatgga attaaccatt taataaagaa atatttacct aaaaaaaagt 2040 cgacgcggcc gc 2052 <210> 92 <211> 748 <212> DNA <213> Homo sapiens <220> <223> Genbank Accession No. AI078144 <220> <221> unsure <222> (1)..(748) <223> n = a or c or g or t <400> 92 ttttgtggat tttcctttta atgcaaaatg ttgcaataca aaacaatgtg gagaaagtcc 60 tgttcctcag gacactgaag ggaggagtga ggaagagagg acagagctgg acgtctcctc 120 ctatttctcc ctccccaagt cactctgagg ggaagaacac tgctgcctgc tccctgggcc 180 tgcccgcata caaggttaga gccctgggtc tggggcatcc ttagcctgaa atttgttgac 240 atggggcagg agagcaggag ggaacattga gggttttgac tcttcgggct ctaaaaggat 300 tactcaggat ctggagttcc gtatgaaaca aaggagctga aagaatttga ttgccattgg 360 ctaaaaatat agaggatttg agccacaact ggcccacatt tgaagaatga ggaacaagaa 420 atttagtggg gatataatat aaatgtatgg gagtgagaaa gatgcaaaaa acaaggctag 480 ctcctcaaac ctcctcctct ttcttcctca tctccagctt atagacaatc tggtagccat 540 catcccaggc atagagctgg cgttctcggg ggttatagcg gaggctggca tgggcaccat 600 atctgcggng aaaataaggg agtgctgccc gttcaggggt cagggtgccg ctggcatcaa 660 aggagcactg gatgcgggcc cgactggcag gacgggtgtt atagacgaca tagaaggtcc 720 cacagatgac aaaggcagcc tcagcatt 748 <210> 93 <211> 602 <212> DNA <213> Homo sapiens <220> <223> Genbank Accession No. AA122235 <220> <221> unsure <222> (1)..(602) <223> n = a or c or g or t <400> 93 gggagattaa aaccttggat tctaggtggt agaggataat ttttttttga atgaatttct 60 ttttatttat ttatttattt ttttcctttt taggatagaa tttttgcggc atttgaagag 120 ctttttccag attatgttta aaattgaaac caagccatgt ggtgaagaac tcaagggtgg 180 ggataaagtg ctgatgacct gtgttggcat tggtttctcc aaccttagca agaccctcaa 240 gtgataacca tcacaagata aggccccaat gcctacagac aaagcagaag ctgccacgga 300 caccaatggg accaagtcca aatggattaa tccaggacag aatagccact tgcttaattt 360 tctgtgaaga aatatcaata tacaaataaa agacatccct gtagcatatg gtttccagct 420 gtttctccag tggcattgca ttgcccagga gggnccagtc accatgagag ctcccttgcc 480 ttacctggag gaagaatgtg cttcaggcac agtcgtgctg ctagaacagt ctcatagctg 540 cagttcantg tcttcctcag ctactatcat angttcctca gccctgtcat atgctgtttc 600 ca 602 <210> 94 <211> 674 <212> DNA <213> Homo sapiens <220> <223> Genbank Accession No. AI342377 <220> <221> unsure <222> (1)..(674) <223> n = a or c or g or t <400> 94 gagatttccc aggactggct ttaatttgaa aaatctgatt ggggtctctt cccgtatcag 60 agaaggaaca gcccaagcta tgaccccagg gccagggaat tcagtcccca ccagaccctg 120 tcattccatc actagggggt aattccaggc tccccctgcc agccctgaga caggaggacg 180 gatgtgaagt tgcccaggac tagattctgt ctctccaaag tggcccaagc cctgttctct 240 gtactaggga agccagctgt gtcttttcga ggacagttgg tccagccagc aggctcagtt 300 cagataccag acaaccattc cagcacgagg gctcagcgcc ctggccccgg cggtcgctcc 360 agtgcctgtg tgcccaccag cacatccatg aggtagtcca attcggcctc gtccagctcc 420 ggagcttcct ccttgcccgg cccatcctca gggcctggtt tgaggccctc agaggctggt 480 gcccanagtt cattgtcata catagaggtg tcaatatcct caaacaggcc ctcaagccca 540 tcgtccagta gacagccagt ggctgggccc agcaggtcca aggcacccag gctgggcgct 600 gctcccccga tgctactggc ctgtgggccc ctcgtctgcc aagggttggg agcctgactc 660 angcccctcg tgcc 674 <210> 95 <211> 1155 <212> DNA <213> Homo sapiens <220> <223> Genbank Accession No. U86529 <400> 95 aagacacggg cctgattcgt cgagtctcac tgagccttag tcgtcggcag gtcccaggcg 60 cgaagtttct cggcctggag gagggggtcg cgcgaagtgc cagatgcagg cggggaagcc 120 catcctctat tcctatttcc gaagctcctg ctcatggaga gttcgaattg ctctggcctt 180 gaaaggcatc gactacaaga cggtgcccat caatctcata aaggataggg gccaacagtt 240 ttctaaggac ttccaggcac tgaatcctat gaagcaggtg ccaaccctga agattgatgg 300 aatcaccatt caccagtcac tggccatcat tgagtatcta gaggagacgc gtcccactcc 360 gcgacttctg cctcaggacc caaagaagag ggccagcgtg cgtatgattt ctgacctcat 420 cgctggtggc atccagcccc tgcagaacct gtctgtcctg aagcaagtgg gagaggagat 480 gcagctgacc tgggcccaga acgccatcac ttgtggcttt aacgccctgg agcagatcct 540 acagagcaca gcgggcatat actgtgtagg agacgaggtg accatggctg atctgtgctt 600 ggtgcctcag gtggcaaatg ctgaaagatt caaggtggat ctcaccccct accctaccat 660 cagctccatc aacaagaggc tgctggtctt ggaggccttc caggtgtctc acccctgccg 720 gcagccagat acacccactg agctgagggc ctagctccca aatcctgccc cgttggcaca 780 gggccacagg agcagaagct gggtgggctg aagaggcctg gaaacgagag tcttaattga 840 ggagatggga gactcgaact ctagccctgg atctgccttc ctgctgaaac ttgttccacc 900 tcagtcccct catctgtcac acgcatgtgg ggtggagtag ggagatgcgg ggagcagggt 960 gggcaggaat actgttatct atgtgacggg gcagtcgtga ggctgagatg agaatgcgga 1020 ttaaaatgcc tggcgtgctc accgtaacac cacggggaag gctgtgtgcc ttttctcatc 1080 cgcttttgtt gtgtgtgact ccaaagaatg cccgcgctga aatttggcgt gaattaaact 1140 gaagcccagg cctct 1155 <210> 96 <211> 391 <212> DNA <213> Homo sapiens <220> <223> Genbank Accession No. AI680350 <220> <221> unsure <222> (1)..(391) <223> n = a or c or g or t <400> 96 tttttcatta aaaaataggg ctctttatta taaattactg aaatgtttct tttctgaata 60 taaatataaa tatgtgcaaa gtttgacttg gattgggatt ttgttgagtt cttcaagcat 120 ctcctaatag cctcaagggc ctgagtaggg gggaggagag aggactggag gtggaatctt 180 tataaaagac agagtgattg aggcagattg taaacattat taaaaaacaa gaaacaaaca 240 aaaaaataga gaaaaaaacc accccaacac acaactgccc tgtccagccc aatacctgac 300 acagaatact ntgtgtttgt ttagttgccc ccccccacaa aaacaaaaac aaaaacaaaa 360 acaaaaaact gttccaggta attccatcgc t 391 <210> 97 <211> 620 <212> DNA <213> Homo sapiens <220> <223> Genbank Accession No. AA576961 <400> 97 gttttttttt tttttaatat cagagtttta atttcaacca gctggcacaa caatgaaagt 60 gtcagacttt ctgaaagtac tcgagaaata atgaataaat tcttaatgtt ttcccctcca 120 ccgccctttt ttattctcca agattaggaa ttactacgga ttaggttttt gaaaataaag 180 tttccttttt ggaaaatggt ctacattcag aaatgtctta gaacaagcat ttaaaaaaaa 240 ctaataaata atcataaatc aaaatacatt aaaataaaat tacagtacat catcgctcct 300 agaaaattca ccatacaaga cgatcctttc aaaggttcat aaataaaagt cttcttgact 360 cgaaatcgtt tcctgcatcg tgatgaaaag tatgcagaaa actaagaaga atcgcaagtt 420 ttcagtaggg tgatgtccaa actacttgat ctggtgcggg gcggagagac tgttttgctt 480 ttgatccaag tgaagacaat agaaatgtgc tcgtcccact tcctcaagtc ctcaaaacct 540 tgtcttgccc gggagctgcc cctttcaggc agagttggag gtgctgcgga gaagccggtg 600 cccgtgcggc tgcgagtgcg 620 <210> 98 <211> 1108 <212> DNA <213> Homo sapiens <220> <223> Genbank Accession No. U75744 <400> 98 ggcagagcag gggtagactt agcatgtaag ggagggtcag ttggtcctgc aacaggtagg 60 acatccctcg ggtacaatgg agcagcacca ggatgtcacg ggagctggcc ccactgctgc 120 ttctcctcct ctccatccac agcgccctgg ccatgaggat ctgctccttc aacgtcaggt 180 cctttgggga aagcaagcag gaagacaaga atgccatgga tgtcattgtg aaggtcatca 240 aacgctgtga catcatactc gtgatggaaa tcaaggacag caacaacagg atctgcccca 300 tactgatgga gaagctgaac agaaattcaa ggagaggcat aacgtacaac tatgtgatta 360 gctctcggct tggaagaaaa acatataaag aacaatatgc ctttctctac aaggaaaagc 420 tggtgtctgt gaagaggagt tatcactacc atgactatca ggatggagac gcagatgtgt 480 tttccaggga gccctttgtg gtctggttcc aatctcccca cactgctgtc aaagacttcg 540 tgattatccc cctgcacacc accccagaga catccgttaa ggagatcgat gagttggttg 600 aggtctacac ggacgtgaaa caccgctgga aggcggagaa tttcattttc atgggtgact 660 tcaatgccgg ctgcagctac gtccccaaga aggcctggaa gaacatccgc ttgaggactg 720 accccaggtt tgtttggctg atcggggacc aagaggacac cacggtgaag aagagcacca 780 actgtgcata tgacaggatt gtgcttagag gacaagaaat cgtcagttct gttgttccca 840 agtcaaacag tgtttttgac ttccagaaag cttacaagct gactgaagag gaggccctgg 900 atgtcagcga ccactttcca gttgaattta aactacagtc ttcaagggcc ttcaccaaca 960 gcaaaaaatc tgtcactcta aggaagaaaa caaagagcaa acgctcctag acccaagggt 1020 ctcatcttat taaccatttc ttgcctctaa ataaaatgtc tctaacagat atgaactgct 1080 ccctgtactt aggaaaaaaa aaaaaaaa 1108 <210> 99 <211> 3921 <212> DNA <213> Homo sapiens <220> <223> Genbank Accession No. M59371 <400> 99 cggaagttgc gcgcaggccg gcgggcggga gcggacaccg aggccggcgt gcaggcgtgc 60 gggtgtgcgg gagccgggct cggggggatc ggaccgagag cgagaagcgc ggcatggagc 120 tccaggcagc ccgcgcctgc ttcgccctgc tgtggggctg tgcgctggcc gcggccgcgg 180 cggcgcaggg caaggaagtg gtactgctgg actttgctgc agctggaggg gagctcggct 240 ggctcacaca cccgtatggc aaagggtggg acctgatgca gaacatcatg aatgacatgc 300 cgatctacat gtactccgtg tgcaacgtga tgtctggcga ccaggacaac tggctccgca 360 ccaactgggt gtaccgagga gaggctgagc gtaacaactt tgagctcaac tttactgtac 420 gtgactgcaa cagcttccct ggtggcgcca gctcctgcaa ggagactttc aacctctact 480 atgccgagtc ggacctggac tacggcacca acttccagaa gcgcctgttc accaagattg 540 acaccattgc gcccgatgag atcaccgtca gcagcgactt cgaggcacgc cacgtgaagc 600 tgaacgtgga ggagcgctcc gtggggccgc tcacccgcaa aggcttctac ctggccttcc 660 aggatatcgg tgcctgtgtg gcgctgctct ccgtccgtgt ctactacaag aagtgccccg 720 agctgctgca gggcctggcc cacttccctg agaccatcgc cggctctgat gcaccttccc 780 tggccactgt ggccggcacc tgtgtggacc atgccgtggt gccaccgggg ggtgaagagc 840 cccgtatgca ctgtgcagtg gatggcgagt ggctggtgcc cattgggcag tgcctgtgcc 900 aggcaggcta cgagaaggtg gaggatgcct gccaggcctg ctcgcctgga ttttttaagt 960 ttgaggcatc tgagagcccc tgcttggagt gccctgagca cacgctgcca tcccctgagg 1020 gtgccacctc ctgcgagtgt gaggaaggct tcttccgggc acctcaggac ccagcgtcga 1080 tgccttgcac acgaccccct tccgccccac actacctcac agccgtgggc atgggtgcca 1140 aggtggagct gcgctggacg ccccctcagg acagcggggg ccgcgaggac attgtctaca 1200 gcgtcacctg cgaacagtgc tggcccgagt ctggggaatg cgggccgtgt gaggccagtg 1260 tgcgctactc ggagcctcct cacggactga cccgcaccag tgtgacagtg agcgacctgg 1320 agccccacat gaactacacc ttcaccgtgg aggcccgcaa tggcgtctca ggcctggtaa 1380 ccagccgcag cttccgtact gccagtgtca gcatcaacca gacagagccc cccaaggtga 1440 ggctggaggg ccgcagcacc acctcgctta gcgtctcctg gagcatcccc ccgccgcagc 1500 agagccgagt gtggaagtac gaggtcactt accgcaagaa gggagactcc aacagctaca 1560 atgtgcgccg caccgagggt ttctccgtga ccctggacga cctggcccca gacaccacct 1620 acctggtcca ggtgcaggca ctgacgcagg agggccaggg ggccggcagc aaggtgcacg 1680 aattccagac gctgtccccg gagggatctg gcaacttggc ggtgattggc ggcgtggctg 1740 tcggtgtggt cctgcttctg gtgctggcag gagttggctt ctttatccac cgcaggagga 1800 agaaccagcg tgcccgccag tccccggagg acgtttactt ctccaagtca gaacaactga 1860 agcccctgaa gacatacgtg gacccccaca catatgagga ccccaaccag gctgtgttga 1920 agttcactac cgagatccat ccatcctgtg tcactcggca gaaggtgatc ggagcaggag 1980 agtttgggga ggtgtacaag ggcatgctga agacatcctc ggggaagaag gaggtgccgg 2040 tggccatcaa gacgctgaaa gccggctaca cagagaagca gcgagtggac ttcctcggcg 2100 aggccggcat catgggccag ttcagccacc acaacatcat ccgcctagag ggcgtcatct 2160 ccaaatacaa gcccatgatg atcatcactg agtacatgga gaatggggcc ctggacaagt 2220 tccttcggga gaaggatggc gagttcagcg tgctgcagct ggtgggcatg ctgcggggca 2280 tcgcagctgg catgaagtac ctggccaaca tgaactatgt gcaccgtgac ctggctgccc 2340 gcaacatcct cgtcaacagc aacctggtct gcaaggtgtc tgactttggc ctgtcccgcg 2400 tgctggagga cgaccccgag gccacctaca ccaccagtgg cggcaagatc cccatccgct 2460 ggaccgcccc ggaggccatt tcctaccgga agttcacctc tgccagcgac gtgtggagct 2520 ttggcattgt catgtgggag gtgatgacct atggcgagcg gccctactgg gagttgtcca 2580 accacgaggt gatgaaagcc atcaatgatg gcttccggct ccccacaccc atggactgcc 2640 cctccgccat ctaccagctc atgatgcagt gctggcagca ggagcgtgcc cgccgcccca 2700 agttcgctga catcgtcagc atcctggaca agctcattcg tgcccctgac tccctcaaga 2760 ccctggctga ctttgacccc cgcgtgtcta tccggctccc cagcacgagc ggctcggagg 2820 gggtgccctt ccgcacggtg tccgagtggc tggagtccat caagatgcag cagtatacgg 2880 agcacttcat ggcggccggc tacactgcca tcgagaaggt ggtgcagatg accaacgacg 2940 acatcaagag gattggggtg cggctgcccg gccaccagaa gcgcatcgcc tacagcctgc 3000 tgggactcaa ggaccaggtg aacactgtgg ggatccccat ctgagcctcg acagggcctg 3060 gagccccatc ggccaagaat acttgaagaa acagagtggc ctccctgctg tgccatgctg 3120 ggccactggg gactttattt atttctagtt ctttcctccc cctgcaactt ccgctgaggg 3180 gtctcggatg acaccctggc ctgaactgag gagatgacca gggatgctgg gctgggccct 3240 ctttccctgc gagacgcaca cagctgagca cttagcaggc accgccacgt cccagcatcc 3300 ctggagcagg agccccgcca cagccttcgg acagacatat aggatattcc caagccgacc 3360 ttccctccgc cttctcccac atgaggccat ctcaggagat ggagggcttg gcccagcgcc 3420 aagtaaacag ggtacctcaa gccccatttc ctcacactaa gagggcagac tgtgaacttg 3480 actgggtgag acccaaagcg gtccctgtcc ctctagtgcc ttctttagac cctcgggccc 3540 catcctcatc cctgactggc caaacccttg ctttcctggg cctttgcaag atgcttggtt 3600 gtgttgaggt ttttaaatat atattttgta ctttgtggag agaatgtgtg tgtgtggcag 3660 ggggccccgc cagggctggg gacagagggt gtcaaacatt cgtgagctgg ggactcaggg 3720 accggtgctg caggagtgtc ctgcccatgc cccagtcggc cccatctctc atccttttgg 3780 ataagtttct attctgtcag tgttaaagat tttgttttgt tggacatttt tttcgaatct 3840 taatttatta ttttttttat atttattgtt agaaaatgac ttatttctgc tctggaataa 3900 agttgcagat gattcaaacc g 3921 <210> 100 <211> 1247 <212> DNA <213> Homo sapiens <220> <223> Genbank Accession No. AF040639 <220> <221> unsure <222> (1)..(1238) <223> n = a or c or g or t <400> 100 ggaattcgcc gcccgctccg agcctggtgc ttccgaccgc tgcgcgcggc tcctgggctg 60 tcacagtctc ccgttgccgc cgtcatgtcc cggcagctgt cgcgggcccg gccagccacg 120 gtgctgggcg ccatggagat ggggcgccgc atggacgcgc ccaccagcgc cgcagtcacg 180 cgcgccttcc tggagcgcgg ccacaccgag atagacacgg ccttcgtgta cagcgacggc 240 cagtccgaga ccatccttgg cggcctgggg ctccggctgg gcggcagcga ctgcagagtg 300 aaaattgata ccaaggccat tccactgttt gggaactccc tgaagcctga cagtctccgg 360 ttccagctgg agacgtcact gaagcggctg cagtgtcccc gagtggacct cttctacctg 420 catatgccag accacagcac cccggtggaa gagacactgc gtgcctgcca ccagctgcac 480 caggagggca agttcatgga gcttggcctc tccaactatg cagcctggga agtggccgag 540 atctgtaccc tctgcaagag caacggctgg atcctgccca ctgtgtacca gggcatgtac 600 aatgccatca cccggcaggt ggaaacggag ctcttcccct gcctcaggca ctttggactg 660 aggttctatg ccttcaaccc tctggctggg ggcctgctga ccggcaagta caagtatgag 720 gacaaggatg ggaaacagcc tgtgggccgc ttctttggga atacctgggc agagatgtac 780 aggaatcgct actggaagga gcaccacttt gagggcattg ccctggtgga gaaggccctg 840 caggccgcgt atggcgccag cgcccccagc atgacctcgg ccaccctccg gtggatgtac 900 caccactcac agctgcaggg tgcccacggg gacgcggtca tcctgggcat gtccagcctg 960 gagcagctgg agcagaactt ggcagcggca gaggaagggc ccctggagcc ggctgtcgtg 1020 gacgccttta atcaagcctg gcatttggtt gctcacgaat gtcccaacta cttccgctag 1080 gcccatcgtt tctcaggctg cccaaggctc ttctgtaaca tcttttgtta ctcacatttt 1140 ctttaattta gaactgcctc agtaaattct tagggatgga agtntttgga caaaaaccta 1200 atagaagagt caccaccaaa tgaagaataa aactcccaaa aaaaaaa 1247 <210> 101 <211> 1450 <212> DNA <213> Homo sapiens <220> <223> Genbank Accession No. M12963 <400> 101 gatgcacttg agcagggaag aaatccacaa ggactcacca gtctcctggt ctgcagagaa 60 gacagaatca acatgagcac agcaggaaaa gtaatcaaat gcaaagcagc tgtgctatgg 120 gagttaaaga aacccttttc cattgaggag gtggaggttg cacctcctaa ggcccatgaa 180 gttcgtatta agatggtggc tgtaggaatc tgtggcacag atgaccacgt ggttagtggt 240 accatggtga ccccacttcc tgtgatttta ggccatgagg cagccggcat cgtggagagt 300 gttggagaag gggtgactac agtcaaacca ggtgataaag tcatcccact cgctattcct 360 cagtgtggaa aatgcagaat ttgtaaaaac ccggagagca actactgctt gaaaaacgat 420 gtaagcaatc ctcaggggac cctgcaggat ggcaccagca ggttcacctg caggaggaag 480 cccatccacc acttccttgg catcagcacc ttctcacagt acacagtggt ggatgaaaat 540 gcagtagcca aaattgatgc agcctcgcct ctagagaaag tctgtctcat tggctgtgga 600 ttttcaactg gttatgggtc tgcagtcaat gttgccaagg tcaccccagg ctctacctgt 660 gctgtgtttg gcctgggagg ggtcggccta tctgctatta tgggctgtaa agcagctggg 720 gcagccagaa tcattgcggt ggacatcaac aaggacaaat ttgcaaaggc caaagagttg 780 ggtgccactg aatgcatcaa ccctcaagac tacaagaaac ccatccagga ggtgctaaag 840 gaaatgactg atggaggtgt ggatttttca tttgaagtca tcggtcggct tgacaccatg 900 atggcttccc tgttatgttg tcatgaggca tgtggcacaa gtgtcatcgt aggggtacct 960 cctgattccc aaaacctctc aatgaaccct atgctgctac tgactggacg tacctggaag 1020 ggagctattc ttggtggctt taaaagtaaa gaatgtgtcc caaaacttgt ggctgatttt 1080 atggctaaga agttttcatt ggatgcatta ataacccatg ttttaccttt tgaaaaaata 1140 aatgaaggat ttgacctgct tcactctggg aaaagtatcc gtaccattct gatgttttga 1200 gacaatacag atgttttccc ttgtggcagt cttcagcctc ctctacccta catgatctgg 1260 agcaacagct gggaaatatc attaattctg ctcatcacag attttatcaa taaattacat 1320 ttgggggctt tccaaagaaa tggaaattga tgtaaaatta tttttcaagc aaatgtttaa 1380 aatccaaatg agaactaaat aaagtgttga acatcagctg gggaattgaa gccaataaac 1440 cttccttctt 1450 <210> 102 <211> 38059 <212> DNA <213> Homo sapiens <220> <223> Genbank Accession No. K02402 <400> 102 gtatatctag aaaaccccat tgtctcattc caaaatcacc ttaagatgga taggcaactt 60 cagcaaagtc tcaggataac aaaatcaatg tgcaaaaatc acaggcattc ttatacacca 120 atagcagaca aacagacagc caaatcatga gtgaactccc attcacaatt gcttcaaaga 180 gaataaaata cctaggaatc ctacttacaa gggatgtgaa ggacctcttc aaggagaact 240 acaaaccact gctcaatgaa ataaaagagg atacaaacaa atggaagaac attacatgct 300 catgggtagg aagaatcaat atcatgaaaa tggccataat gcccaaggta atttatagat 360 tcaatgccat ccccatcaag ctaccaatga ctttcttcac agaattggaa aaaactactt 420 taaagttcat atggaaccaa aaaagagccc gcatcgccaa gtcaatccta agccaaaaga 480 acaaagctgg aggcatcatg ctacctgact tcaaactata ctacaaggct acagtaacca 540 aaacagcatg gtactggtac caaaacagag atacagacca atggaacaga acagagccct 600 cagaaataat gccacatatc tacaactatc tgatctttga aaaacctgac aaaaacaaga 660 aatggggaaa ggaatcccta attaataaat ggtgctggga aaactggcta gccatatgta 720 gaaagctgaa actggatccc ttccttatac cttatacaaa aattaattca agatggatta 780 aagacttcat tgttagacct aaaaccataa aaaccctaga agaaaaccta ggcaatacca 840 ttcaggacat aggcatgggc ttggacttca tgtctaaaac accaaaagca atggcaacaa 900 aagccaaaat tgacaaatgg gatcaaatga aactaaagag cttctgcaca gcaaaagaaa 960 ctaccatcag agtgaacagg caacctaaag aatgggagaa aatttttgca atctactcat 1020 ctgtccaagg gctaatatct agaatctaaa atgaactcaa acaaatttac agaaaaaaac 1080 aaacaacccc atcaacaagt gggtgaagga tatgaacaga cacttctcaa aagaagacat 1140 ttatgcagcc aacagacaca tgaaaaaatg ctcagcatca ccggccatca gagaaatgca 1200 aatcaaaacc acaatgagat accatctcac acaagttaga atggcgatca tcaaaaactc 1260 aggaagcaac aggtgctgga gaggatgtgg agaaatagga acactttgac actgttggtg 1320 ggactgtaaa ctagttcaac cattgtggaa gtcagtgtgg cgattcctca gggatctaga 1380 cctagaaata ccatctgacc cagccatccc attattgggt atataccaaa gtattataaa 1440 tcatgctgct ataaagacac atgcacacgt atgtttattg cggcactttt cacaatagca 1500 atgacttgga accaacccaa atgtccaaca atgatagact ggattaagaa aatgtggcac 1560 atatacacct aggaatacta ggcagccata aaaagaaaat gagttcatgt cctttgtagg 1620 gcatggatga agctagaaac catcattctc agcaaactat cgcaaggaca aaaaaccaaa 1680 caccgcatgt tctcactcat aggtgggaac tgaacaatga gaacacttgg acacaggaag 1740 gggaacatca cacaccgggg cctgttgtgg ggtggggggc gaggggaggg atagcattag 1800 gggatatacc taatgctaaa tgacgagtta atgggtacag cacaccaaca tggcacatgt 1860 atacatatgt aacaaacctg ctcgttgtgc acatgtaccc taaaacttaa agtataataa 1920 taaaaaaaag atcattctaa aatttataca agcccttaga acagttaaaa atatcttacc 1980 aaaagaagaa taaagttgga ggaatcactc tacctaatat aaagtcttac tacatagcta 2040 cagtaattat gacagtgtta tattggcaga gggataaata catcaatggc acaaagaata 2100 gatagagaaa ctggaagtag acccaaaaca atatggttaa ctgacttacg aaaaaatttc 2160 agaagccatt cagtcgagga aggatagggt ggtattgttg ttttttgttt taacaaattg 2220 tgctggataa attggacata cctatggaaa aaaaaatgaa gtttgaccta aacatcatac 2280 tttacacaaa tattaactca aaatggagca tgggcataaa tctaaaactt caaactgtaa 2340 aacatttaga aaaaaatagg aaaaaaacta tcaggatcta gtgttagtgg aagagttcta 2400 aatgtgatcc ataaaacaaa aacaaataaa ctggactaca tcaaaactaa aaaattctac 2460 tctgtgaaag acctaattaa gaggacaaaa gacaagctac aggctggaga caatatattt 2520 aatccacgta tctatgaaag gattcatatc tagaatatat aaacaacctt aagaatctga 2580 cagtaaaaaa aaaaaatcag actaactgga ccactcatac attgctgatg gaaatgtaaa 2640 gtggtacagc cattttggta aacatcattg ctctctgaca aagatacggt gggtcccact 2700 gatgaactgt gctgccacag taaatgtagc cactatgcct atctccattc tgaagatgtg 2760 tcacttcctg tttcagactc aaatcagcca cagtggcaga agcccacgaa atcagaggtg 2820 aaatttaata atgaccactg cccattctct tcacttgtcc caagaggcca ttggaaatag 2880 tccaaagacc cattgaggga gatggacatt atttcccaga agtaaataca gctcagcttg 2940 tactttggta caactaatcg accttaccac tttcacaatc tgctagcaaa ggttatgcag 3000 cgcgtgaaca tgatcatggc agaatcacca ggcctcatca ccatctgcct tttaggatat 3060 ctactcagtg ctgaatgtac aggtttgttt ccttttttaa aatacattga gtatgcttgc 3120 cttttagata tagaaatatc tgatgctgtc ttcttcacta aattttgatt acatgatttg 3180 acagcaatat tgaagagtct aacagccagc acgcaggttg gtaagtactg gttctttgtt 3240 agctaggttt tcttcttctt catttttaaa actaaataga tcgacaatgc ttatgatgca 3300 tttatgttta ataaacactg ttcagttcat gatttggtca tgtaattcct gttagaaaac 3360 attcatctcc ttggtttaaa aaaattaaaa gtgggaaaac aaagaaatag cagaatatag 3420 tgaaaaaaaa taaccacatt atttttgttt ggacttacca ctttgaaatc aaaatgggaa 3480 acaaaagcac aaacaatggc cttatttaca caaaaagtct gattttaaga tatatgacat 3540 ttcaaggttt cagaagtatg taatgaggtg tgtctctaat tttttaaatt atatatcttc 3600 aatttaaagt tttagttaaa acataaagat taacctttca ttagcaagct gttagttatc 3660 accaaagctt ttcatggatt aggaaaaaat cattttgtct ctatgtcaaa catcttggag 3720 tttgattatt tggggaaaca caatactcag ttgagttccc taggggagaa aagcaagctt 3780 aagaattgac ataaagagta ggaagttagc taatgcaaca tatatcactt tgttttttca 3840 caactacagt gactttatgt atttcccaga ggaaggcata cagggaagaa attatcccat 3900 ttggacaaac agcatgttct cacaggaagc atttatcaca cttacttgtc aactttctag 3960 aatcaaatct agtagctgac agtaccagga tcaggggtgc caaccctaag cacccccaga 4020 aagctgactg gccctgtggt tcccactcca gacatgatgt cagctgtgaa atcagactga 4080 aatgctgaaa taacgataaa aaaaaataca gaggttaaac tagcaaagtg agtaaagtca 4140 agggataaag aaaatttgtt ggaaaactca caaagcagga cataaagcaa ggccattaga 4200 tatatctcat tagtgtgaca tctgggagga caaagcatcc aaaccctttc ttctatataa 4260 gtggtgagat gatgaaggtt gtaagaggct tctgccccct tgaagacttc agatgctggg 4320 gaaaggatag ataagaataa ggatgaacct ggcttttgga gcctgggaaa taatgactag 4380 cgataaacct gaagggaagt taagtatacg atccccagat aatactaagg agaaaggcaa 4440 tgtgattctg cagccattgt agccagagat aataagccct tgaggaaggg gccaggggaa 4500 tttttctaag gatagacagt attaatgcag cactctcttc tgctattaaa ctctcattgg 4560 cttctaaaag gagtttcggt gagtgatttg ctgagatgtt tgcattttca tgctgctgcc 4620 tttaggttat tattgcaaca gtttggaatt ttgaaattaa aacagttctg taaaaccagt 4680 ttagttttgt aaagtgtatg catcaaagat gtccttcatt cagacattac tgagttacaa 4740 ctacggtgcc aggtactgtg tcagggtact aggggtatgg ggataaacca gactccctct 4800 ttgatctaaa gcagcatgag gccaggtgag aggtttcaat atatgtgata aaatgtgcac 4860 taggtactaa gggatcatag agaaaggaac acattaaatg gggaaacaat tgatagagag 4920 agaatatttt catctgggtc ttaaaagatg agtaggcgtt ctctctcttt aaatgtctga 4980 tataagggca ttttatgcaa agaaggatca ctcgtgcaaa gactcagctt tgcaagaacg 5040 tgaggtattt caggagtttt gtatggttcc atatggacta tgacaagtga gacaggtaaa 5100 ctaggcagag ctggtcatca gataatgaag tcattaacct aaggagattg gacaataaaa 5160 tgcaatatgg aggtatcgaa gtataaacat aaggagtacc actgatggct gatttaggat 5220 gcccagtctg gcaacacgct aatgaaatga tagtggggga gggggccgta ccaagactag 5280 gagagagcag tcctgagact attgcaatta tctgcgggag acataaaggc tagaacctga 5340 acagtagcag tacaaaaaaa gaggggagtt caaatgatat taaggaagta gaagtggtat 5400 gacttaacca tctgggtatg gaaggggaaa tggctagagt cttggggact ttgtgtttga 5460 tgtgattatg gaccacagaa taatgtctaa gagaactggc tctttagtct gactgccaga 5520 gtctgaatcc tgaatgtttt agtatgttac cttgcaaagc ccttagcctc tatgaatcta 5580 tcttcctcat ttataaaaat aagatgacag tgcctatctc gtgggacttt tgtgaggatg 5640 aagtgagata atggatgcaa agttactgag cacagtgtcc aacacagcag aagcattaca 5700 tatacattag ctattactgg ctacattatg atatacagtt agggagttgg aaagataatc 5760 tgaaattcag gagacgtatc tgactatagg tgagtatttg gaactcattg ttctgtaaac 5820 agtagttaca gcacgtgtgt gggcatctgg agagtgagca tggatattgt gatacctagt 5880 acagtgcctg gcagtagtgg ttgtatgctc agtaaatttt gttgacaggg tcagggccgg 5940 actagactgt ggtaagcaag gcctgtaggg cataaatata cttgtatgcc ccgagaagtg 6000 aggacctctt aaatattgtg ccctacatgc cttgtttggt tcactcttgt cccagcccta 6060 gcaagtatat ataaggtgaa aaaggaaaaa gctgaggctg gagcctggga gaaccctgga 6120 catttaaggg ccatggagag gaacaggagt taatcaattc aagtgctgga tggataacag 6180 gagttagagc aaagcgggga accagaatag agtgattatt ataaaaagag tttcctaaaa 6240 agggagagat caacaattag aaattattta gagcagccag taaatacata aactcaaaat 6300 tattctttag gtcattcctg attgtgacaa tagtcatttc attatataaa tgtgattaag 6360 gaaggaaaag agctacacag aagttattaa agagctaaag agaattgaga aatttaaaac 6420 agaagaaagt agggccaaca tgaaaggagt agggagaaaa agagataacc agcatattgt 6480 ctcactgatc ctgccaacac ctgtgagata gatattctta ttatactact gttaaaccta 6540 atttacattt gacaaagtta aggttcagag cttgtgtgac ttgtccaagg tcacaggtct 6600 agaggaggca gatacttgat tcaaacctat ttctgtctga tctgattcta aagtctgttt 6660 tttcactcaa ccacactgta cagtcagctc tccttgtgag ttccacagcc acagattcaa 6720 ttaactgcag atcaaaaata ttcaagaaaa aaatggatgg ttcgatctct actgaacatg 6780 tacagactct tttatctttc attattccct aaacaataca gcataacaac tatttacata 6840 gcatttacat tgtattagct attaagagaa acctagagat gatttaaagt acaaaggagg 6900 atgtgtttag gttatatgca aatagtaagc catttttata tcggagactt gagcatccac 6960 agatcttgat atttgcaggg ggtcttgcca ccaattttcc atggatactg aggaacgact 7020 gtaaatggat gcaggcatgg atgctattta ggagtgtcca gggccaagta aatgagttgc 7080 tgagcagaga ggtgggtgga ggctgtgagg catcaatatg tggtggcatc catctgcatt 7140 ttggtgattt ttttccttca cagtcctcgg ctgtctggga agagaaggat gaaggcagat 7200 ggctgctcca atttaggggc taggattgca gggtgggcac agcattgcaa acgagtgaag 7260 gaaattgaga aatatggcca atgaagagtt gaagagaggc ctggcatggt ggctcacacc 7320 tataatccca gcactttcag aggcccaggc aggcagatca cttgaggtca ggagttcgac 7380 accagcctgg ccaacaaggt gaaatggtga aaccccggct ttactaaaaa tacaaaaatt 7440 agctgggcat ggtggcgggt gcctgtaatc ccagctactt gggaggctga ggcaggagaa 7500 tagcttgaac ctgggagatg gaggttgcag tgagctgaga tcgcaccact gcactccagc 7560 ctgggcgaca gagcaagact ctgtcaaaaa aaaaagagtt gaagagaaaa agtctaggct 7620 aaattcaaag aaaaaaagtg agcccaaaag gaacttgcag agcaagggaa aagcagggat 7680 gtcaagggac tagaacactc cataaagtga acagctgcaa tgaaaataag ggaagaaagt 7740 ttagttcatc tccgtttctt tcctttcctt tttactttcc tttctcttcc tttttggagt 7800 tagtcaggaa gtagtcccaa ataccccaga aagttcatct tataagccct tggtcctctt 7860 gagatggtat cagatatatt gctagaccct tgaagaaagg aacaactcca ggcaacttct 7920 tgagtccctg ttattaattt tatacataca cacacatata tgtatataca tgaaaacaca 7980 caaacacatg tgtgtgtata cagccatgca ttccttaaca atggggatat attctgagaa 8040 atgtgtcatt aagcaatttc atcattgtgc gaacataata gagtgtactt acctaaacct 8100 aaatggtata gcttactaca tacctaggtt gtattgatgt ggcctattgc tcctaggctc 8160 ctgggctgca aacctgtaca gcatgtgact gtactgaaca ctgtaggcaa tggtaacagt 8220 ggtatttgtg tatctaaaca tagaaaaggt acagtgaaaa tacagtatta taaccttatg 8280 ggaccactgt cgtataatgt ggtccatcat tgaccaaaat gtcattgtgc agcaaatgat 8340 tatctcatat atatatatat atgatatgat atatatgata tatatgtgtg tgtatatatg 8400 tatacatata tatgtgtaca tatatgtata catatataca cacacatata tatgtacaca 8460 catatatgta tatatatgta cacacatata tgtatatata tgtacacaca tatatgtata 8520 tatatatgta cacacatata tgtatatata tatgtacaca cacacacata gagagagaga 8580 gagaggagag gagaggaagg agggagggaa ggagaaatat gattcagata gagacatcta 8640 tcctccagag ttcaggagtg tctcttcaga ctaggtagat gtagcttaaa aaaaacatat 8700 cctggaattc tagagagatg cttaaatcac tgcaattcct ataacacttg ccaaccaaag 8760 gtgctgttga tctgaaattg cttttttaaa ttaatgcagt gatttttctt taacatctag 8820 tgacagacac tggggtcaca tttgcagctg gaccataatt aggcttctgt tcttcaggag 8880 acatttgttc aaagtcattt gggcaaccat attctgaaaa cagcccagcc agggtgatgg 8940 atcactttgc aaagatcctc aatgagctat tttcaagtga tgacaaagtg tgaagttaac 9000 cgctcaattt gagttctttc tttttcatcc aaagtaaatt caaatatgat tagaaatctg 9060 accttttatt actggaattc tcttgactaa aagtaaaatt gaattttaat tcctaaatct 9120 ccatgtgtat acagtactgt gggaacatca cagattttgg ctccatgccc taaagagaaa 9180 ttggctttca gattatttgg attaaaaaca aagactttct taagagatgt aaaattttca 9240 tgatgttttc ttttttgcta aaactaaaga attattcttt tacatttcag tttttcttga 9300 tcatgaaaac gccaacaaaa ttctgaatcg gccaaagagg tataattcag gtaaattgga 9360 agagtttgtt caagggaacc ttgagagaga atgtatggaa gaaaagtgta gttttgaaga 9420 agcacgagaa gtttttgaaa acactgaaag aacagtgagt atttccacat aatacccttc 9480 agatgcagag catagaatag aaaatcttta aaaagacact tctctttaaa attttaaagc 9540 atccatatat atttatgtat gttaaatgtt ataaaagata ggaaatcaat accaaaacac 9600 tttagatatt accgttaatt tgtcttcttt tattctttat agactgaatt ttggaagcag 9660 tatgttggta agcaattcat tttatcctct agctaatata tgaaacatat gagaattatg 9720 tgggtttttt ctctgcataa atagataata tattaaactt tgtcaaaagg actcagaaag 9780 atcagtccaa ccctctaacc catattggat ggtgatatac tacagggtta tgccagtgtg 9840 ggaactatcg ctggtaaata agtttaatcc tccctagggc ttcacaaaga acattgttcc 9900 accccaggag ggtggaagga agaaactgaa atgattgtgt cttagaacct aatgaaagtt 9960 tgcattcctc agtaaaatca gagactgctg attgacttaa atgtttatag cttcaaagtc 10020 ctcctcatta tcatggccca gaagcccttc catgattgtc cttccccacc ctccccatta 10080 cccttcttgc ctcctctgct acttctctcc tcgcacactg ggctccagcc accctggcct 10140 tcctgtcact tcttgcacac tctaggaatg ctcccacttt ggaggcttta tctggctgtt 10200 tctcttattt ggctgttccc aacttcctgt gggctgactc cctcacctcc ttcgggtctt 10260 tgcccaaatg ttaccatctt aatgaggcct accttcacca tctattaata cttcaacctg 10320 ccccagtagc cttaccactc tagacacctg tacagaactc cactctactt tttaacagag 10380 cttttcacca tctaatgtat catataattt cttactcata ctatttatca tttattttct 10440 cctactccac taaaatgcaa gtttcatgtt ggcagggata ttcaattgtt ttgtttattg 10500 atatattcct agcacctaga acagtatctg gaaaagaggt actcagtaaa tatttatcaa 10560 atgaattgac caaaagaagg aaaactcaaa actttaatga caactaactt taaagctaca 10620 ataacttaaa attcagagta ggattttgag ggagggtaag tttcaaagat tgacttacct 10680 aagactatct gcataaataa aaagaaatta atccagacaa caaattcacc aacttccatc 10740 aattggaaat ccaattctat tttctacagt ttatgttctg gagacactac tggacactct 10800 tttactctca taactcataa ctcctccact tttgttttta aatcatgaga gaaaaagagt 10860 tgactctgtt atattgtttt atctaccttt ccttgatctt agaaacgaat actaccatac 10920 cagcttctac tgaggtgccc cctaaagtta gtccaaatag gtctttgcaa tctccattcc 10980 cgcagaattt agaactttga atcacatgat ttatttctaa aagtaaatcc atgccgattt 11040 tccccaccaa aaaattcctg actattaaac tcctacaatc ccttcattgc tcactcccca 11100 cccccaggat catattttaa agttgggccc ttgccttttg ggtcacatag gtacactgtt 11160 tgctatacca caggtatagc tatctggaaa acatggaggg tattattctg ttactactgc 11220 ttcgtcaacc aaaaaataaa acaaaacaag aacaaaaaag aaacaaactc cctgcctctt 11280 ttcacttgca gtcaaggttc ctaaccacta caaaattagc ctatgtttct tcttgcacat 11340 agtagaaacc caagcttctc actgctgtgc tattctgtac catcaactca tcacataaag 11400 agcctggttg aagaatgatt gtccaaccac attactagca tctgtcaaga ctttccagtt 11460 tacaaaaggc ctatcacatt taaccctcac accatccttg tgaccaaagc attattaact 11520 ccattttaca ggagagtaaa ctgaagctta gggaagttaa aagaactgcc aaaggtctcc 11580 cagttgggga gtcatgaagc ccagaagaga agccaaattc tctgctgctc aaccccttgc 11640 tttcactatt acacctcagg gccttcaaat ctaaatgcag ttattcatta aacaggaacc 11700 tggtagtctt aaacaggaat ctctcacttg gtaagatctt gtctcttgtt gtatttgacc 11760 ccaactgtct atggctttgc ctgaacccaa agtacacaca gcctagaaac caaaggagaa 11820 ccaaatgtgg gataaaatga cactcatttt aacgacatgt ctcagcaaat gagttcctgt 11880 gtagctggct gaaagcccag accctttcag taaaacatcc tgaataattc acatttgttg 11940 gtctataata taaagggcaa atgtagctca tttttagacc agttctgaac atcaatagta 12000 acaaaccaga gataaccgat tttgttttca tagaattgga acaaattaga gtatctgtgc 12060 aaaagcatat cagatctagg agcagagggg acaaggtcta atttttaaat aagcaaattt 12120 tccagggagg gactacttat gataaaggga tattagtctc ttagtcaacg gaacctggat 12180 acacgcttct gacagagaag agggagaata ggcaggaatc tacacaccag atgtcaagga 12240 gatttgcttt aaaatacgac tgataattag aaatttctca gtttccccct tttccctcat 12300 tctttgattc ttattgttat ctttatctct tactcctttg tttctcatat attgagtctt 12360 acagatcaag ctcccatttt tttcttcagg ggtatttttc tagttcaaag tgcctaccat 12420 ctcccttctg gttctattca tccttctctc ccaaagctcc tttagaagtg tggattaagg 12480 cagagcacta agaaaccaga cttaaagatt cccttctcat tctgactttt ctcctttcac 12540 ctattccttc ctcctgtttt cttaccatca gtgtcttcaa aggctttcaa gtacacggta 12600 aatgcagaaa cttcaagaaa ggcagaatgg aaacataacc aatgcataca taaataaagc 12660 acactgtaga atctttttaa attctgtatg atatatcgaa tgctgtctct cacattacct 12720 agaccatttg aaaccgaatt tgtaaaacat agactatctt taagtagtaa cagatgcttc 12780 tgacatgttt tctattgtct tgaaccatta ctgcatatga tacatcaaag ttaagtgaca 12840 atacaagaaa gcagattcat ttgctccctg cctaggccgt cagttcctaa agtggaaacg 12900 ccatatatta tctagctcag tttgctctac aagacctgca atagagcctt gtgtgacata 12960 gagataatat ttgttgaagc aattaaattt gacttggaat taactctgcc atcattctat 13020 aaggaaggat tgaaaatcct tctcaccctg tgctgatata gtacctttct atacaaaaac 13080 gtccttctcc ctcttccctt ggattgcata aactatgtac atgccttcct caggggcact 13140 tttctaggac agtgtcagcc taaggatctt tgtttgggtg gcttttagaa actcaggaag 13200 acaggagcat catatgccta taggcagctg gcttccaggt cagtagtttt gctctgaccc 13260 taaaatcaga ctcccatccc aatgagtatc tacaggggag gaccgggcat tctaagcagt 13320 ttacgtgcca attcaatttc ttaacctatc tcaaagatgg agatcagtgt gagtccaatc 13380 catgtttaaa tggcggcagt tgcaaggatg acattaattc ctatgaatgt tggtgtccct 13440 ttggatttga aggaaagaac tgtgaattag gtaagtaact attttttgaa tactcatggt 13500 tcaaagtttc cctctgaaac aagttgaaac tggaaaatgc aatattggtg tatcataatt 13560 tttcttaaaa acataccttt gatgcttata aacatttcat ttgtagtgat agttttcagg 13620 atatgagttc aagaagctac attaaaatca ataacaatat ttggtaacta atattaagta 13680 ataatgatgt tccgactcac cttattaatc tttaatacaa ccgtatgtgg ttagtactat 13740 cattatgcgc attctatgca gatgagaaaa ccgcaactcc aacggccaaa aattacagag 13800 gcataaatgg tttagacagg acttaaactt cagtgtgacc aaaacccatg cttctaacta 13860 ctatattcaa aactcagaga aaactgaacc cagaaaattg aaatcatgac taaattgcta 13920 tcaacatagg tgaaagtcaa ttaagtacag aactggagta tgactggcca attatcccat 13980 ataatgggaa ttctccacat gtacaaacca cttcatatgc taaacttgtt gacaacattc 14040 aaagctcatc cctgaatttg actatattga ttacatcgaa aatgttacat agcaacctta 14100 gaatccttgt gtaccttttc ttctcaaagc ctagattatt tctttttccg acgttttcag 14160 taattggagc agtaaacccc agtgtccctt acctacttgt ttattacctc cagatgcaat 14220 attactggta ctgtgattga gaaacgcaca cagtgctaat gaggaattca ctttctactc 14280 tgacactctg gaagaataga gatgcaatcc taaggaagaa tttaacacca caggctacat 14340 gactaaggat aaagagtaga aaattagcag gactctatta accgattaca gcaatccacc 14400 tgacagatga aaaaggcatg aaatgaaatg aaatgtagca gctacactcg tcctattgag 14460 aaaggaaaaa agtcacctgt aatgttgttc agaaatcctt tcagtactaa aaaattcatt 14520 gaccatcttc ctttagtctc gaaaatttct tagaaggtaa aaaaaggaaa aggtgacagg 14580 gcaaagacat ttgaaaagaa agaaaagagt gaatgaactt gcacacctgg cttggactcc 14640 ccattcccct taggtttcca ttgtggggga caaactaatg cctgggttac ctttcttgag 14700 agtgtgttaa ttgattcaat atctctgaag tgctactttc atctgaaagg ttataatttg 14760 aaattcagat ttacctggat aaatttgatc ttgctattat ggaaacctct agaaatcctt 14820 ggagtagtta ctcattatca gcttaaataa tatagccggt ggagctgagg gaatgagtaa 14880 ctcaattagt ctcagttaca actgaagggc acattgttgt aaactataat tgaaaacata 14940 aatatcttta cctagtttaa aaaataaaga tgctttaaaa ggaggaaggg aatagccctg 15000 aggaatgtaa atataagcac aaaacttcta caacagagtt tgctacgtgt gtggctgtgt 15060 tccacccagc aaaaatgcta agtctacaac tgacacaact tggatactct catgttccca 15120 cattttggtt tggtcaaggc tgtgcagttg tactgcaggc caccaccact cctggcctct 15180 acagtatatt gatctgaccc accaatctga tcaaggttta gaaaaatatt ttcagcccag 15240 ttagctcaca aacaaaatga gaattcccac aaattgctct ttatctcaga caacagagga 15300 aagctacagc aaaagcataa acaaattacc atttaagttt gttgcttcaa attaaagact 15360 aattgcaaca gctactagat agcacagttt atggggcatc tcggccccaa gtcttttgtc 15420 ttataaggtc ttgaaaaaaa gaaaggagat tttcatcaat aagagttttt tgttatcttt 15480 ttcccttgtt catcaggccc ttcactgcga gagagaggtg taaacgttca gggcatgcat 15540 tctagttaaa gaatattaat tggctattgg gtccctttgg ttagaataaa gacctctgta 15600 tgatgtccct agctgtacat caaacccaaa tatctctcag ataaatgaag gtctgtaaga 15660 atttggtcat tcctgtctct tctaaagagt aacagaggca ttttcccgca gtaaagtaga 15720 atggaaagaa aacaaaaatc acaagcctat aaacaccttc ttcaattttc ccagcatgtc 15780 acagacacta ctgtcttatt tactacgtat ttctgaggag taaaaaaagg aaatatgttg 15840 agtttagctg aagcacagca tattttgtgg taaacttgtt aaataaaaca tcttttgtcc 15900 aagctttggt tgtcacacaa gtggatatat caggaaatat aaaggcagaa taaactaaag 15960 cagaacatac taacatttgt agtaggcatg aagggaatta gaaagtgttt gtgttaacat 16020 ggagggaggg agaacagatg ctttgagatg ttcttcaaca gatattctag gcactgagac 16080 ccccttcggg accagagaga gcccatatcc accacagtac ctgacacata aatgctcagt 16140 aattgataaa tgagtcccat tctaactgtt ccttagccct gctctatgga actctcccct 16200 gaattccttg tgccattatt ttatttctgg aatcttcagc cttttagctg agggcaaaag 16260 attgctgatt aggaagcaat atttcccacc tcctgcgcaa aacaagccaa agatcaacag 16320 cagcagcaac atactgagcc ctaaagggca atgacaaatg tggagaatga tacagaggtc 16380 tggttacttc ttagccaatg acacagaatc acaattgaga aaacacagag tttattcatt 16440 cccattgtgc atgccctgga caaaccaagc tgcacctttc gtaacttatc acaatctcat 16500 attgacggaa cactttctac aggtaatgtt tgatttggct gaacacttta gcattgcttc 16560 gtagcaacaa aatgatagct agtaacagaa aaagatccag ggatattacc actgttagtg 16620 aggagaaagg ccttttaatt aattaattaa ttaattaata ggaccaagtg ccatcttttt 16680 ggatcatgcc cttagtggat tattggtagc aaaggttaaa gctcaagctg gttcctttgt 16740 ccccctggca acagttgatt tgcctccctt atctcctgaa gtaccgtaag gactaagagc 16800 caattattac atttggctat gctagcatat gtaaaataga gtttaaaagt ttagattcat 16860 cactcaaaaa ttcatattct ccaaaaccat acagtcactc tgttagcctg tgttccccca 16920 gaaaaaaagt cacaagctta ttattaacat gtgcaatcca ggggcaagag aaaggaactg 16980 aagatgaggc agaaaggaaa agaaagccaa taagaggatg agttatcaaa ctactcgttt 17040 cttaacagca actgattgct taacttcctg ggactgtctc caataagtca aattggcctc 17100 aggttagtcc acctgagtgg gaagaagcgg tgaaagaatt tgtctgtcag tatctgtctc 17160 tcattggtta gaagttcgac ttatggggaa ttaactccct cacatttcct agttggatag 17220 cttgggtacc agaggcatat ggcatccatg ctcagcatga acagggaagc ttcaaggcaa 17280 aagacacata gtgcagctat gagccaaggc aattcaagga tacacccata ggaggctggt 17340 tgacatccac ccagagctaa tcaccaccat gctggaaaaa gacacaggtg aagctgagaa 17400 gaatgaaggt ggtgcatagg aggtatctaa tacagtcact cattttcaaa ctttccatgt 17460 tatgattgca ctgaccactg aggatttcta ttgaaagttt tactgttgtc aaacacgtac 17520 acaaggggaa aggtgtctta cattgtttat gttcctgtgc tgctctagaa acagaaatag 17580 gctcaagagc agagcctgtt tttcttaatt cagcaggtct aagctaacaa gtcctgaaac 17640 atggtacttc ctgttattgg tattgcatag gagaaacaaa gggaaagcac agtaattaga 17700 aaatacaaac aagatggcag gaataagcca aaaatatcag gaaacacaat tattgtgaat 17760 tgggattaaa ctaatctatt aataatgaca actttcagct tggagttaaa aatttaattg 17820 tatactgtta acgaaagtga tacctaaaat aaaattacac tgggaggcca aaatgaaggg 17880 atgtgaaaag aactatcagg taaaaactaa caaaaagaaa ctagcaaagc aatcttaata 17940 tcagacaaaa tagaatccaa gaggaaaatc atttcaaaag acaagagatt ttttttatta 18000 ataaggggaa ttgcatagga gagtaaagaa aatgtgggcc actggaatgc ttagcactaa 18060 tgacatattg gtctttggtc ttcagttacc ttacaggacc ctatttcatt ctcttatgtt 18120 tgatatgtaa ccacctcagc cagcttcaag ttgctttttg gccctaatgg acttcctagc 18180 actataattt cttttttttt aaatgtttta ttttaggttt aggggtacat gtgaaggttt 18240 gttacataga taaacatgtg tcacaggggt ttgttgtaca tattattaca tgacgcagat 18300 attcagctca gtaccaaata gtgatctttt ctgctcctct gcctcatccc accctcctcc 18360 ctcaagtaga ctccagtatc tgttgtttcc ttctttgtgt ttataagttc ttaacactta 18420 gctcccgctt acaagtgaga acctgcagta tttgattttt gttcctacgc tagtttccta 18480 aggatgatag cctccagctc cattcatatt cccacaaaag acataatctc cttcttttct 18540 atggctgcat aatattccat ggtatatatg aaccacattt tctttatcca gtctgtcatt 18600 gatgggcatt taggttgatt ccatgtctgc tattctaaca ctgtaatttc taaagacttc 18660 cagattctac ttttataggt aacctgttaa acagtctagc tctggaagcc aagcaatttc 18720 tagaataact aagcaataga aattacactt caatgcagaa aggcagtatc tacatgagat 18780 tatgaaattg cggttgcttt ttgtgttcac tgaaaaaaat aagtaaaact gtaactttca 18840 gaaaaaatga ttgtacatat agaaaaccca aagcatctaa acaattaaaa taaataagta 18900 tagaaagatt actggataca gagtcaacat acaaatatca attgtatgtc tatataccag 18960 caacgattca aaaatgattt ttataatagc attaaaaatt agacgcttag taataaatgt 19020 gagaaagatg tgcaagaact ctacataaaa aattatgaga cgttattgag aaaaattaag 19080 gaaaacctaa ataaatgaat gaataggcaa tgtttatcat taaaggatac aatatagtaa 19140 atatatcaaa tgtttactaa tggattcaat gcaataccaa agtgccagca ggcttttttg 19200 gtggtgggag gtcgggcagg attcataagc taattataaa atgcatatgg aaatgcaaag 19260 agccaaggat agccaagaca gttttgagga agaataaact tgtactactt acactaccag 19320 atgtcaagac ttattatcga gttacattta ttaagacagt gtggtactga cacaaggata 19380 gacaaataga tcagtgaaac acactagagt gctcagaagc acacctgtac atatataaag 19440 gcttgattta tgatagaggt gccagtgcag tagagaagga aattattggt gttttcaata 19500 aaaagtgata ggtcaattag atattcatat ggcatgaagt atgaaacaat aacaatttat 19560 attcataact tgcagaaagc aaaaatttct taaaatacaa aaagtgatca ccataaagga 19620 aaagattgat aaactggact atattaaaac taaggactcc tgttcagcaa aagacactac 19680 ttcgactgaa aagacaagtc acagagtgag acaagatatc tgcaatacag atacctaata 19740 actgaacccc atacagtgat ggtgggaatt taagttcgta caatcatttt agaaaattgc 19800 ttggcagtat ctactagatc tgaacatgtg atccagtaat tacactcata attataagcc 19860 agtaaaaagg catgtttatg tcaccaaaag atatatacaa gaatgttcat tacactatta 19920 tacataagag ccaaaaactg gaaacaaacc aaatatccat taacagtaga atgaataaat 19980 aaaagctgta atagtaatac agtggaatac tacacagcaa tgtaaatgaa ctactgctgt 20040 acaaaacaac atggtttaat ctcacagaca aaatgttaaa tgaaagacac agacgagtac 20100 atattgcgaa cttctgttta taattcaaga actggcaaga actgtttact gtgttagaag 20160 tccaggtaat ggtaacctat aaaaaggaaa aagggtggaa tgattgggag ggggcatctt 20220 ctggggtctt gataatgtgc tatgtattgg tcagtttagt gtttaaacag gctcatttac 20280 tttgtgaaaa cttacactaa aattgtgtgt attttttgaa tatatgttat acattaataa 20340 atagggtttt taaacctgta gttcataatt tagtgaaagt agaatatcca aacatttagt 20400 tttaaaccaa tcaattatag tgctaccatc atttttatgc attattgaga agtttatttt 20460 acctttcttt ccactcttat ttcaaggctc caaaatttct ctccccaacg tatattgggg 20520 gcaacatgaa tgcccccaat gtatatttga cccatacatg agtcagtagt tccatgtact 20580 ttttagaaat gcatgttaaa tgatgctgtt actgtctatt ttgcttcttt tagatgtaac 20640 atgtaacatt aagaatggca gatgcgagca gttttgtaaa aatagtgctg ataacaaggt 20700 ggtttgctcc tgtactgagg gatatcgact tgcagaaaac cagaagtcct gtgaaccagc 20760 aggtcataat ctgaataaga ttttttaaag aaaatctgta tctgaaactt cagcatttta 20820 acaaacctac ataattttaa ttcctacttg aatctgcttc cttttgaaat catagaaaat 20880 atcagtagct tgaattagac caattaattt tctagattgc atcatatttt aaatataact 20940 atgtaatcat ctacaacctg aattctttct gtgtccaatt tgtccaattt ttttctctaa 21000 catttatatc acaaagcaat taatttgtgt gatttctgca tatgtatttg taattcatca 21060 agtcaaatca atgtagtaat actatatcat aaaatataca caaataattg agtgataggc 21120 ttctagtata aggacggtaa gtttgaagca tgattctatc tgggctggct agtttactct 21180 gagaaagtta ttttttattg ttgggtctta agctgagttt acacacttgg tgtcagaatg 21240 attccggcaa tgaactgttt tatgttctgc taggctgatc agcacaatct atatggctgt 21300 gaacaaaaca atgtttccca gtcataccaa ccatgccacc attttaacag ctgattagtg 21360 tattcagaac atctccactc catgttcgta tggctgttat ctaaagatga aagcagtaga 21420 cacttttatt ttttgaaaaa tttaggctct gcagggtcaa ttatatttga taaatgaggg 21480 gcttttttga agcaaactag atataatttc ttttgcattt ctaaagcctg atatcttatt 21540 aattggtaca ttaaattgtg caccatttct ctgtaactgt ttcagtacct gtctcagcac 21600 tataccaggc agaagaaata aagaaagaac cagtgccaga tcagcttggt caggagaccc 21660 taatcctgcg gcactagagg aattaaagac acacacacag aaatatagag tatggagtgg 21720 gaaatcaggg gtctcacagc cttcagagct gagagccccg aacagagatt tacccacata 21780 tttattgaca gcaagccagt cataagattt actgaaagta ttccttatgg gaaataaagg 21840 gatgagtctg gctagttatc tgcagcagga acatgtcctt aaggcacaaa tcacttatgc 21900 aattgtctgt ggtttaagaa cacctttaag cagttttccg ccctgggtgg gccaggtgtt 21960 ccttgccctc attctggtaa acccacaacc ttccagtgtg gatatcaagg ccatcacgag 22020 catatcacag tgctgcagag attttgttta tggccagttt tggggccagt ttatggccag 22080 atttggaggc ctgttcccaa caaaccagaa gctaggaata tatatcctgc aaataaaatg 22140 aagaatctct aaggcttcag ggcctgccca cttgttcttc tgcctggttc ttcacataca 22200 ctgtctcaaa gctagtctac cttgagagga gcatgaatat gtgtgtgggt gtgtgtctgt 22260 gtattttaac cttaaaaacc taacttccag tatagacaga tggcatacta gctaaaccct 22320 tacaagttct tctatgctat aaaagagaaa cagaattgag aaccacctcc aactattaag 22380 tgttatattt gaatatagcc ttagctttag cagaataagt aggccaaact taaaataagc 22440 ttttctgcct tttcaatgat aaaggtccct tttctgtagc cattgttgat tgtgtacact 22500 tatacataag tattttgaac taatttcctg ttttctcaac cacttgctgt cttcatgata 22560 ctttgtcgca gctggttgct atagaaatgt ctgttacaag gaatgtggct tgaaggaaag 22620 tgataaatga aaatgaaatg tgaagtgact ttgtttgact acaaattccc attctggtag 22680 tccccagtgt atcaatacat tatttttctt tagaaaataa accaacccaa ggaaaaatgg 22740 tgggcaggtc ctggtgaata tggctgtgat aattatatta gcaatctctt tggctaatat 22800 ttgaagccca aataattgaa tcacaatgat ctctccccag aaaatatata aaatgcacct 22860 tggaatctag aaggcctttt agtctgcaaa agaaaccttc ttaatcataa gcagcagaag 22920 tcccatttac caaattggaa agttaaagtt acaaagcatc aatcatcaga cttccattca 22980 gggatggcaa ttgggagtaa gactttttag taaagaaact aaacacaaag tcattagact 23040 ctgtaaaagt cttaccaaat ttgattctgg aacacctatt ctatttccgt aaagatgatg 23100 aattcggagc caaatgttct tttcatgaag gatttgaaaa ctgtccatga aaataacgca 23160 atcaaccttt tagcttgaga ctctattcac tgattagatt tttttaaata ctgatgggcc 23220 tgcttctcag aagtgacaag gatgggcctc aatctcaatt tttgtaatac atgttccatt 23280 tgccaatgag aaatatcagg ttactaattt ttcttctatt tttctagtgc catttccatg 23340 tggaagagtt tctgtttcac aaacttctaa gctcacccgt gctgaggctg tttttcctga 23400 tgtggactat gtaaattcta ctgaagctga aaccattttg gataacatca ctcaaagcac 23460 ccaatcattt aatgacttca ctcgggttgt tggtggagaa gatgccaaac caggtcaatt 23520 cccttggcag gtactttata ctgatggtgt gtcaaaactg gagctcagct ggcaagacac 23580 aggccaggtg ggagactgag gctattttac tagacagacc tattgggatg tgagaagtat 23640 ttaggcaagt ttcagcacta accaatgtga gaaggcctcc agagatgagc agttggtgaa 23700 agagaggctc aaaaccagct accatacagg tcaagaagaa tttggcatta aggaaacagc 23760 atagcaggat tccagacagg caactggtca acaacatgaa ggtctggaag aaaggtcgca 23820 gtactcaggt tcagggcact acttcagctt cagcccttgc aaaaactggt gagagttgga 23880 aagtctttag gctaagaaaa attggattat ttaaaagggg taaagaaagg gactcaagga 23940 ggaaggatta aggcaagaac taggttccaa gaaacagggc atgagagaga gtcttgatct 24000 accactatag ttctcgtggt agcatcagaa tcacctggga acgtagaaat gcaaattctc 24060 ctgctctaca ctagacctac caaatcagaa tatctagggg gtggggccca gcagtctgtg 24120 cgcaaacaag cactgcaggt gattttgatg cacattatag tttgaaaact aggccaggtg 24180 cagtggctca tgccaataat cccagcactt tgggagactg agacgggagg attgcttaaa 24240 cccaggagtt tgagaccagc ctgggcaaca cggcgaaacc ccacctctaa ttaaaaaaaa 24300 tacaaaaatt agctaggtgt gatggctccc acctgtgctc ccagctattc aggaggctga 24360 ggtgggagaa tcacctgagc ctggaaagtc gaggctgcag tgaattgtga tcacaccact 24420 gcacttcagc ctgagtgaca gagtaagacc ctatctcaaa aaacagaaaa agaaaaacac 24480 tggcccaaag gaaatgaact tgttacagaa gccggggttc aaaacaccaa ataatgcact 24540 tgtacctagt ccttcccggg tgctctgcag acatttctcc aagcgtagtc tgcaaacaac 24600 ctacatatgt agaattacct atgcacattt ttcatttaac aaccaagagc tacatttgta 24660 gcaaaatctg ggttgtaact tagcctacag ctgaagccta agagattccg tctgtgagaa 24720 gaaataaccc acctctttgg cccccctccc caggcaggaa gccaggatgg tccttatata 24780 aagttgtgct gtccaatagg taaccactag ccacatatgg ctatttaaat ttaaattaac 24840 tacaattaag agaaattaaa aattcaattc ctcaattgca cctgccaaat tttaagcaca 24900 taacaaccac atgtggctag taactactgt attggagagt gcaagcggag atagaacact 24960 ctattactgc agaaatttct attggatagc acttataata gtttagtgta acttaaaact 25020 ccctagttgc cacagtcatg atttagtagt aatttcatgg atttctctac tgaggttaga 25080 atctctgcca ttagagactg ataaatttaa agtttgcaat tatcaaactg gtgacaattt 25140 aagccagaat caggtaatgt cctcagtttt aacagcattg gaattttctg ggactagctg 25200 tgtatctatc caggattctt gagaatgcct gccatttttc aacataatgg atgtaaggta 25260 ttacacatat acctggggat ggggaggtag gtataattgc acaagcattg tggagaatgg 25320 tatcaaagag tggcagaaca tcacaatcaa ggttttccct ttcttttacc tttgcttttt 25380 aaaaagacaa tatttgctgg acctgatctt ataactcata aatgggacac tgtatgttcc 25440 tttttacctc ctctgtttct acttaattgc accctatgag gactgcttcc cttacctacc 25500 ataacccctt ccttcactca tccatatctt tactcttctt cacaactctg taatattgac 25560 cttctttatg aacctttcct ggaacaatcc ctcttaatgc aagcactgtt attatgcctt 25620 caatgtattt aatatccatg tatctattct ctctaatttt gtcattttgt gttctcatgt 25680 attttcattc attatgtgtc caacttccat ggataacatg gttacaacaa aagatcctac 25740 tttatgacaa ttatcttcct tgggtttgtg ggacatagaa cagtgcacag agtaggggat 25800 ccaagaaccc aggagaatat attagctaag aagataactt ccgtttttaa aagtccaaga 25860 ttcaggagat caaaaccatc ctggctaaca tagtgaaacc ccgtctcttc caaaaataca 25920 aaaaattagc ccggcgtggt ggcaggcgcc tatagtccca gctacacggg aggctgaggc 25980 aggagaatgg cgtgaaccgg ggaggcggag ctggcagtga gccgagatcc cgccactgca 26040 ctccagcctg ggcgacagag cgagactccg tctcaaaaaa aaaaaaaaaa aaaaagtcca 26100 agattttaaa aaaaaaaaaa aaaaggatgt ctgctttgtg agtttagcat tgtctccttg 26160 tcattccaga aatgaaatgg caaatacatt taaatcagaa ctaaaaaggg gaacagggta 26220 taaaggctca atttagtcac atcatttccg tttctcaccc acccccttta aaccagatgt 26280 ttgccaatgc attaacaatg cagatgtttc ctgaaagaaa gtttagtaac tcaagcagac 26340 accttatttt cttttcaagc agaaaagact atgagatggt ggttgtggtt gttccgggag 26400 ggagaagata taaatgatac acattatttc aaatcatttc atgacctcac tgcacactta 26460 tagttattgt acctgttgtc tttttgctgt caagcctagc taagatcatt tggaatgttc 26520 aagatcactc atacatgcat gtgcacacat acacatgcac atatgttcac tccctatttc 26580 atccacatga actaagatta ctgatgtgta cagattcaaa gcacttttat tcttttccaa 26640 aggcaagaag ctgagctact ttccagaata gttgtgaaag accctgtcat acttctgcat 26700 tgtttcctcc acaccacctc catccagttc cttatgaatg gttactggtt ttcaaaaata 26760 tgagataaat tgagtgtata aaagtcattt ttagacaaaa tgaaacagga aatgaaagaa 26820 accagaatct ctcctcattt gtggatgggc cagctccacc atgtcatggt taatctgcag 26880 ggaggaaata ctagatttga ttgcagatca gactgcagca aacctgctgt gactaaggca 26940 tcaagagaaa gcaagcaaca gactggggct tcagtggtga aaacattata tatctagctt 27000 tgaaatatga aatactgttt agcagtgtca cctagaaaag agtgtttcaa aatgctgatg 27060 cttcataaga acctttctct tcagagttgg tttcttttat ctttcaaatt agccagggtg 27120 ggaaataaag tgatcacttg gtgaagaaat ctcacaaaga agaacataga gagttcactt 27180 tcatctggag taatgaacag attgaacaaa ctagaaatgg ttagtctgtt aaagaaaagg 27240 tgtaggtgag ctgtttgcaa gagccacaag ggaaagggga agacaacttc tttgtggact 27300 taagggtgaa agttgcaagc aggcaagacg attctgacct ccattaagaa agcccaaacc 27360 aaccaacaac cactgggttg gttacgcagg ttgggcagca ttgggagcaa atgttgattg 27420 aacaaatgtt tgtcggaatt gttgacttaa agagctgttc tgtcactggg gacagcagcg 27480 gctagatagc cccattcagg gagagggcat ttgttcacct ggccagagat cagagcaggc 27540 taagggactg ctgggatcct gtccagcttt gagaccctac agagccatgt tcacctagca 27600 cgtatcccgt ctgcggtcac ggtcatttct taccttattc cagggctttc acctcagctt 27660 gccaggctgg agccaagggc caacgcagcc gcgccttgtt cgcgatggta gcttcccagg 27720 agccccctat ggttccggaa cgcgctgccg gccccatcct gtttgctacc tcctaaagcc 27780 aaaggcactg gcgggccggg ccagcttcta aagtcgcgca aggttagaag gttccggaca 27840 ggaacggcgt gaggccaatg gaaggaggta cttcagtttc cctccagatg cccagcgatg 27900 ggctcagagc tccttgagaa ctcgggaaag gaagcagggt ctctgaagaa atacttcagg 27960 agtagaaaga ggaagctaga gggttaaatg cactacacag gaacagaaat gagtttttct 28020 tagagttagt atatgtctag aggtgtagta aactaaaaca agtcttgaat tgcataccgc 28080 cacgtaggga agaaatgaaa acctttgaat attagtgaaa aaagggaaac tgcaacgcct 28140 gtattactag atagctttca tcaacagctc aaaaccgaca gatttaaaga agcaacaccg 28200 cattttggct ttctaaagct ttaatttggt ttggatccca tgcccatgac cctgccagct 28260 gacaattcta agcatgcgca aactggcccc aaaaattcct cccacatttc cgaagaacta 28320 tttggccctt tatgtgaagt acctggtttt tccattttct gttttaccat aggcctcagt 28380 tcggtgtgtg gcgtatttat tctacattta acaatttgaa gatcattcta ttagattaaa 28440 aaaaaagaat acaatggaag ccaagtgatt aagctttcct tatgcttata ttaagttgta 28500 gcatatgcat ttaccgatag ttaaccgtat taacctacag aaaatgtcca gggaaatggt 28560 ctatttctta ttctattttt gacctaaaga aaatctttaa aatgtcttag cattttcccc 28620 agtctccatc cacttccctc agctttggcc tgaagctatc tttaaaggta ccctgtacaa 28680 gctcttgccc tgtacagcta gctacagaga ttcaatcctt tctgttcgat taggacacat 28740 ctcagtggca gataacatgc aaagttatta tatgtatgaa ccagaacttg tttttcctta 28800 ggggccagga tgttacacta aggtcttaag actatagtaa tatcttcact tgaaaaagcc 28860 ctctattatt cctatctcag atgataaaaa ttcaattaag agaaataaga acgtgacatg 28920 tgtaatcgca cctggctcta caaagctagt ctggacagac atttaaacaa ttatcctcta 28980 agattatttg atgaaatgca tttcaatgac tagttaacca ttaaaaacca aagtgagcat 29040 cccatctgtt cccagtcaaa tgacctagag caaaggacta ggcaaaccac atctgtgggc 29100 atagcaagct gtacatcaca aacaaatgaa tttgctttgt atatgagtga gagcaaacac 29160 tctttattgt acaacttggg tgggtaagta gggagaataa tggttttact gaaatcgcag 29220 gtaacggtta cgttggagtt aaaggttagg aagaaaacca aagggtaaga gctgttgttc 29280 tgggctggca ttgtcaatga agagcataaa ttcagatgtg aatgtatatt ttgtagaagc 29340 atgtgtgttg ttggtttttg tgtatgtgtg agtctgaaag agggaaaaca ggctcccatt 29400 agactatgac taacaaaaat gtttgacaga ttataactca gatgtcttac tcagagcata 29460 tgccttccca ttttccccat tattccccaa catgatgtct ttaagaactt gtccttgacc 29520 gagcagacat ctcatacccc aaatagctaa tattttgata gctatgatcc tgaacggcca 29580 aacattccaa aaccaagtag tttgtaatat ctttaatgca aatatatttt aggccttttc 29640 cttggcaagg atgtttggtc aggggttggc aaaaataatg ctcttcagac ttaaaagaac 29700 acaaccatat ttcttagcca tccaccagaa agtagtagaa cgctccagga agcaagtctt 29760 tgtcaggagt cagactagct acatcataat ctctctgccc aggggctgtg gatgtcatcc 29820 atcctggcct aactagccta ctgagctgag agatgtccaa tttcccccca atacactaac 29880 cagaggagaa ggaccgtgat atcattgcat gtgaattctt aattccaatt gcttaaacaa 29940 atatgttcag ttgtaactat caataccagt atataacagt gttggccaag ttttattgat 30000 gctgacaatc aattggagtt acagccagac acatggtctt atgaccggcg tacttacgca 30060 gggctttgca ctgagacagg tcgtgcatct gaggtttact gctttgcatt tttgttttgt 30120 aactgaagtc tgatgagaca gccagagcat gtgctaccta gggacttgaa tccctgcagc 30180 cccatttcac ttctcaccac cttccggggt ggtttctcga cctcccactc ccctaccacc 30240 tggtgcctta gccagccctg gctctccctc caaacacctg cccaatgagc actgccaccc 30300 catggtgccc agacatgctc tccctcctca tccctaccta gctaccattg ccactcccct 30360 cccccagcgg ggacatgggc ataggagcag ggagagttaa ggttggtcag gtgcacgtgc 30420 cctatgctat cttggaaggg ggcttggcca tgtggcatct ctggaccaag aatgcgccac 30480 agcacatttg gagggtgaat ggtgggggca caccccttgt ccacctctat ttcaggcatg 30540 gaacacatcc tggcatgaaa gttgcagtcc cttgggaatc acctctccac cttgattgcc 30600 acagtaggcc agtgacaagg gaagattgac acatcatccc tgctggggcc cagtgtcctg 30660 tggctggcag gcaggggatc ctaaggacat gtgggtctta aattgtaggg tgcacttcct 30720 gggcaccttt gagggtctgc actgccccag caaatatccc catgctagaa ggagcaaaat 30780 attaaatggc aaattttaaa aatgtaacaa gatgggttgc aaaagagact acagaggaaa 30840 gcaaaagttt tgtattttag tatcttccat ggcacttttc ttcctagctt ttgaacaagg 30900 ggccccacat ttttatttct cactgagccc cacaaagtat gtagccattc ctgcccggag 30960 tgaggacttt taaaacataa agattatcaa gtcttggaaa ttctgattca gtagatatat 31020 aacaggtctc aaacttaatt atgtaaagaa tattctggag agcttccttt tacccagtcc 31080 cacccaccaa atattctgat aaattaagct tcgattagcc cccagatctg cattttataa 31140 ggatccccag atgattctac tgcaattggt ccacagacca tgcctggacc gaatttgggt 31200 gcttaggagc acaaattctg gagccgggca gacttgagtt tgcttcctag ctttaccaac 31260 tgatctcagg ggagttaatg tttacctcta aactttagct catgcatcta taaataaata 31320 tattaatatc atgtcataag gatattatgt tgtattaaat gtctttaaaa caccacaatg 31380 attagcccaa agtaaacact caataaatgt tcaaaaattt aggaaaattg ttaagactgg 31440 gttgtatgca cactggtgtt tattatatta tgtagttttt tctgtatttt tacaacattt 31500 cagaattaaa agcaacagct agaaaaagag ggaaatggcc gggtgcagtc gtcacgcctg 31560 taatcccagc actttgggag gccaaggcgg gcggatcacg aggtcgagag atcgagacca 31620 tcctggccaa catggtgaaa ccccatctct actaaaaata caaaaattaa ctgggcatgg 31680 tggcatgcgc ctgtagtccc aggagaattg cttgaacctg ggaggcggag gttgcagtga 31740 gccaagatct caccactgct ctccagcctg gtgacagggc aagactccgt caaaaaaaaa 31800 aaagagaggg agagccagag tatgaaaaag gaagtcagag ccctttaatg agtcagcttt 31860 gtaggtctcc aggtaggagg ctagtgcttc agtgtctagg acatagtagg tgttcagtaa 31920 attaaattca ggacaaaaag aacatgcccc aaggaccatc tgatatccac ttaaagtgat 31980 ggactacctc gtttcccttg tttatgaatg ggttcatgcc taagactgtg tgcactttaa 32040 tacaagggca gtcgttcaga actagtcagg tcctgaaaag gatttaccaa atgttgagtg 32100 tgccctctag tgttcacact tcccagcttt cttcctataa aggtggatca aggcacttgc 32160 ttacaactgg aactgaaatc ctccaagtcg atctagacat tgagatggag aaaatattca 32220 ttgtcgactg taattatgca acgaatatcc agttgagata atggacttgc ctcttatcta 32280 ataataccca ggctcaatgc gtcactgctt tgtccacttt gcccaaaatt caagcacagc 32340 taagttgata ttttaggaca aaggcagctt actatccagc cagaggggag tagaatatgg 32400 ttaagagaga gtggaaagaa tgaatgagcc ctgctattcc tcactgcctg gatggctata 32460 agcacagccc ttatggaggc cttaggtctt gcttcacaat attccagttt gaaaagggtt 32520 tgaaaagacc tcctagaaaa atcagtagtt tttctctttt gagtaacatg tagcaaaaaa 32580 aatttcatca tgtaggtaca gggaacaccc tagtaactat taatctcaag gagtcaagcc 32640 agtgtgtttc ctaatgtatc tgctgtatcc ccatgaagca aattttgcca tcagagaaac 32700 tgactcatgg ggaaaaaatc caaggacctc aaatcaccaa aagaagccat tcctcagatt 32760 tgcctaagct taagcttccc tgtctctcat tgtgtgttgc tttcaatgca gttacataaa 32820 tggctttttt gtttatgcac caaaaacact aattcatctg caaagctcac atttccagaa 32880 acattccatt tctgccagca cctagaagcc aatattttgc ctattcctgt aaccagcaca 32940 catatttatt tttttctaga tcaaatgtat tatgcagtaa gagtcttaat tttgttttca 33000 caggttgttt tgaatggtaa agttgatgca ttctgtggag gctctatcgt taatgaaaaa 33060 tggattgtaa ctgctgccca ctgtgttgaa actggtgtta aaattacagt tgtcgcaggt 33120 aaatacacag aaagaataat aatctgcagc accactagct ctttaatatg attggtacac 33180 catattttac taaggtctaa taaaattgtt gttgaataaa ttgggctaaa ggcagaaggg 33240 tcataatttc agaacccacg tcgcaccgtc ctccaagcat ccatagttct tttgatatac 33300 ccctattatc actcatttca gtgaggtaca attagttctt gatgtagcca tttccatacc 33360 agaaggcctt cccaaaaatc agtgtcatgt caccgatcct tttatctctg gtgcttggca 33420 caacctgtag caggtcctca gaaaacaaac atttgaatta atggccaaat gagtttgtgc 33480 tcaaaaaagg ggtgaggata cttgaaattt ggaaaatcta ggataattca tgactagtgg 33540 attcattatc accaatgaaa ggcttataac agcatgagtg aacagaacca tctctatgat 33600 agtcctgaat ggctttttgg tctgaaaaat atgcattggc tctcattaca tttaaccaaa 33660 attatcacaa tataagaatg agatctttaa cattgccaat taggtcagtg gtcccaagta 33720 gtcacttaga aaatctgtgt atgtgaaata ctgtttgtga cttaaaatga aatttatttt 33780 taataggtga acataatatt gaggagacag aacatacaga gcaaaagcga aatgtgattc 33840 gaattattcc tcaccacaac tacaatgcag ctattaataa gtacaaccat gacattgccc 33900 ttctggaact ggacgaaccc ttagtgctaa acagctacgt tacacctatt tgcattgctg 33960 acaaggaata cacgaacatc ttcctcaaat ttggatctgg ctatgtaagt ggctggggaa 34020 gagtcttcca caaagggaga tcagctttag ttcttcagta ccttagagtt ccacttgttg 34080 accgagccac atgtcttcga tctacaaagt tcaccatcta taacaacatg ttctgtgctg 34140 gcttccatga aggaggtaga gattcatgtc aaggagatag tgggggaccc catgttactg 34200 aagtggaagg gaccagtttc ttaactggaa ttattagctg gggtgaagag tgtgcaatga 34260 aaggcaaata tggaatatat accaaggtat cccggtatgt caactggatt aaggaaaaaa 34320 caaagctcac ttaatgaaag atggatttcc aaggttaatt cattggaatt gaaaattaac 34380 agggcctctc actaactaat cactttccca tcttttgtta gatttgaata tatacattct 34440 atgatcattg ctttttctct ttacagggga gaatttcata ttttacctga gcaaattgat 34500 tagaaaatgg aaccactaga ggaatataat gtgttaggaa attacagtca tttctaaggg 34560 cccagccctt gacaaaattg tgaagttaaa ttctccactc tgtccatcag atactatggt 34620 tctccactat ggcaactaac tcactcaatt ttccctcctt agcagcattc catcttcccg 34680 atcttctttg cttctccaac caaaacatca atgtttatta gttctgtata cagtacagga 34740 tctttggtct actctatcac aaggccagta ccacactcat gaagaaagaa cacaggagta 34800 gctgagaggc taaaactcat caaaaacact actccttttc ctctacccta ttcctcaatc 34860 ttttaccttt tccaaatccc aatccccaaa tcagtttttc tctttcttac tccctctctc 34920 ccttttaccc tccatggtcg ttaaaggaga gatggggagc atcattctgt tatacttctg 34980 tacacagtta tacatgtcta tcaaacccag acttgcttcc atagtggaga cttgcttttc 35040 agaacatagg gatgaagtaa ggtgcctgaa aagtttgggg gaaaagtttc tttcagagag 35100 ttaagttatt ttatatatat aatatatata taaaatatat aatatacaat ataaatatat 35160 agtgtgtgtg tgtatgcgtg tgtgtagaca cacacgcata cacacatata atggaagcaa 35220 taagccattc taagagcttg tatggttatg gaggtctgac taggcatgat ttcacgaagg 35280 caagattggc atatcattgt aactaaaaaa gctgacattg acccagacat attgtactct 35340 ttctaaaaat aataataata atgctaacag aaagaagaga accgttcgtt tgcaatctac 35400 agctagtaga gactttgagg aagaattcaa cagtgtgtct tcagcagtgt tcagagccaa 35460 gcaagaagtt gaagttgcct agaccagagg acataagtat catgtctcct ttaactagca 35520 taccccgaag tggagaaggg tgcagcaggc tcaaaggcat aagtcattcc aatcagccaa 35580 ctaagttgtc cttttctggt ttcgtgttca ccatggaaca ttttgattat agttaatcct 35640 tctatcttga atcttctaga gagttgctga ccaactgacg tatgtttccc tttgtgaatt 35700 aataaactgg tgttctggtt cataccttgg ctttttgtgg attccattga tgtgaatcag 35760 tcaccctgta tttgatgatg catgggacta ctgacaaaat cactctgacc ctgccaagct 35820 gctgccttct cctgccccaa cctcaccccc agccaggcct cactcttgct agttccttta 35880 gttcttttag tcaatatatt tttgtcttcg catataagta taaataaaca tatttttaaa 35940 tttcttggct gggcccagtg gctcacgcct ataatcccag cacttctgga ggccaaggtg 36000 ggcggatcac ctgaggttag gagtttcagg ccagcctggc caacatggtg aaaccctgtc 36060 tctactaaaa atagaacaat tagctgggct tggtaatgtg cacctataat cccagctact 36120 ggggaggctg aggcaggaga atcacttgag cctggggagc agggggtgcg ggaggttgca 36180 gtgagacaag atcgcaccag tgcactcccc atcctgggtg acagagtgag actctgtctc 36240 aaagaaaata aataaataaa tacatttctt gaggcgtttc ttgttaaatc attcatggag 36300 aggcatccca aacaccacat tcaacaaaac actctgaaaa atgttttcaa atgcaatata 36360 acacagcaga gatttgatgc tctgttatcc agttttcata taaggctgtg tgagctgtgt 36420 cccagagagg acagtggtct gaatccacct gagacagaat tgggtctaac taactgtgag 36480 tatggccttc aataagtcac tctccatttg ggaatttgat ttctccactt gtataatgag 36540 agtatttgac aggatgctct cccaaatccc ttgcaatttt gttagtctgt gatttcatgt 36600 ttttattttt attccttcat ccaacaaata gtcaaggagt aattgctgtg tgccaaatac 36660 caacagtatt cattaaattg taattcagat tttatatata tataaataat gtataatgtg 36720 tataaattgc tttgtgagtg cctactacac tgctagacag tagttgctca ataacttgtt 36780 agctgaatca gaatccatgt ttatcccaga gtagcaatta gtcttgcatc gagtatcgtg 36840 aaagaaggcc acacttaaat aagaataatg cctggggttt aggttttatg aaaaaatgaa 36900 aggaaattag ttctgctttt gttgactaaa ggaagggaag agagaagaga cactataatt 36960 gtctgcctca gatttaagga ggaggctaat tcatgcatta aacacgttac ttcaaatttg 37020 aatgaccaaa ggtctgtagc ctcagcactt caaaattggt aaaagtaaga cactctggcc 37080 ttgtttccat agagaccacc ccttacaaag gcaccaatgg gaaactggcc tcaggactcc 37140 tgttattggt cttctctgtg gcagagaaag gagctcttgg acccataaat ctctgagcca 37200 cagttctttt tgccatgggc tcaaaaatga ttgaattcat catgagccac ctgtggcata 37260 ttgccacact aaacatgtgg ggcctttaag ctcactaaga gccaatgtct tcagagccag 37320 ccctggcttg attctaccta gggcatttgc agttgccata taagaatcat tagtgctttc 37380 aaaattactg tagatacttt gcctaaatag actaaaacat gctgccgtca tattggaagt 37440 gacagattaa aatagaactc ttgccaagtg aaggaaagtg tgctaatata atgcagtcat 37500 tttaacttgc tgtttaagtg tgattgtttt tagttctttt gaatattatt tgttttatac 37560 tgacaggaac gaagtactgt ccaattttct ctgccaagga aaaaagaaaa ggtgttcttc 37620 cttacttacc tgaaccaaaa cagaccagtt tacaaaattg cctaattata attgctaaac 37680 aagttccgaa tgcttacagt ctaatccaag aatgtcagag ctgcaagggc ccttaaacac 37740 catccaatcc actccactca tttagcagat gaagagattg agggcaacat aaggccaggc 37800 ccaagataac acaatgacag ccaggactag agctcaagtc tcccaccctg cactttgaaa 37860 gaataatgct ttcaactgga gtacattaac tctactgtct atatttttag ggcagctggg 37920 gcattctgca ttggtggcaa tcctctcaac aaccctggga ctgaaaactg cctggaattc 37980 ttactaacaa ttctctaatt gaccaaaagg tgacgaaatc aaggagacca ataaggtagc 38040 cttggaaagc aagagtggc 38059 <210> 103 <211> 1855 <212> DNA <213> Homo sapiens <220> <223> Genbank Accession No. J05428 <400> 103 tgcattgcac caggatgtct gtgaaatgga cttcagtaat tttgctaata caactgagct 60 tttgctttag ctctgggaat tgtggaaagg tgctggtgtg ggcagcagaa tacagccatt 120 ggatgaatat aaagacaatc ctggatgagc ttattcagag aggtcatgag gtgactgtac 180 tggcatcttc agcttccatt ctttttgatc ccaacaactc atccgctctt aaaattgaaa 240 tttatcccac atctttaact aaaactgagt tggagaattt catcatgcaa cagattaaga 300 gatggtcaga ccttccaaaa gatacatttt ggttatattt ttcacaagta caggaaatca 360 tgtcaatatt tggtgacata actagaaagt tctgtaaaga tgtagtttca aataagaaat 420 ttatgaaaaa agtacaagag tcaagatttg acgtcatttt tgcagatgct atttttccct 480 gtagtgagct gctggctgag ctatttaaca taccctttgt gtacagtctc agcttctctc 540 ctggctacac ttttgaaaag catagtggag gatttatttt ccctccttcc tacgtacctg 600 ttgttatgtc agaattaact gatcaaatga ctttcatgga gagggtaaaa aatatgatct 660 atgtgcttta ctttgacttt tggttcgaaa tatttgacat gaagaagtgg gatcagtttt 720 atagtgaagt tctaggaaga cccactacgt tatctgagac aatggggaaa gctgacgtat 780 ggcttattcg aaactcctgg aattttcagt ttcctcatcc actcttacca aatgttgatt 840 ttgttggagg actccactgc aaacctgcca aacccctgcc taaggaaatg gaagactttg 900 tacagagctc tggagaaaat ggtgttgtgg tgttttctct ggggtcaatg gtcagtaaca 960 tgacagaaga aagggccaac gtaattgcat cagccctggc ccagatccca caaaaggttc 1020 tgtggagatt tgatgggaat aaaccagata ccttaggtct caatactcgg ctgtataagt 1080 ggatacccca gaatgacctt ctaggtcatc caaagaccag agcttttata actcatggtg 1140 gagccaatgg catctacgag gcaatctacc atgggatccc tatggtgggg attccattgt 1200 ttgccgatca acctgataac attgctcaca tgaaggccag gggagcagct gttagagtgg 1260 acttcaacac aatgtcgagt acagacttgc tgaatgcatt gaagagagta attaatgatc 1320 cttcatataa agagaatgtt atgaaattat caagaattca acatgatcaa ccagtgaagc 1380 ccctggatcg agcagtcttc tggattgaat ttgtcatgcg ccacaaagga gctaaacacc 1440 ttcgggttgc agcccacgac ctcacctggt tccagtacca ctctttggat gtgattgggt 1500 tcctgctggt ctgtgtggca actgtgatat ttatcgtcac aaaatgttgt ctgttttgtt 1560 tctggaagtt tgctagaaaa gcaaagaagg gaaaaaatga ttagttatat ctgagatttg 1620 aagctggaaa acctgatagg tgagactact tcagtttatt ccagcaagaa agattgtgat 1680 gcaagatttc tttcttcctg agacaaaaaa aaaaaaaaga aaaaaaaatc ttttcaaaat 1740 ttactttgtc aaataaaaat ttgtttttca gagatttacc acccagttca tggttagaaa 1800 tattttgtgg caatgaagaa aacactacgg aaaataaaaa ataagataaa gcctt 1855 <210> 104 <211> 547 <212> DNA <213> Homo sapiens <220> <223> Genbank Accession No. AI819354 <400> 104 ttttatgttt agtttaagaa ttttatttta aaggaatttc tgtggcataa cataaggttt 60 atggtacttt tactaaaagt cacttataat gaccaaatta taacaatttt tgcaataagc 120 tctcattaaa ttttcctaaa agtagaaaaa gtacacatta tataccattt tgcacttaat 180 tacttcttta aaatctcaaa ataattcagt gtaaaatgtt agtttcaaag acaatttatg 240 ggaaattaca aagcaactac aaagttcttc ataataaatc caagataaaa gtaacttttt 300 acaggttgaa agtttttcaa aatgcctaag tggattataa atacagtttg gccatctgat 360 gaatttagag gcactttaaa aggtgtctag ttgaactact acagatagga catgtttgag 420 gaaatttaat ctttaagtct aataccagtg ttcatttctt cctgccaaaa caagaaattt 480 attggaaaaa tccatgagca gcatgattag tttgatttct ttctcttttt ttagagacag 540 ggtcttg 547 <210> 105 <211> 2282 <212> DNA <213> Homo sapiens <220> <223> Genbank Accession No. L32140 <400> 105 ccccgagtct ctgcgccttc acatagttgt cacaggacta aagcaaattg atccaggggg 60 aaacactgta gaccgtgtat ataaaaacac tctataaact gcaatgctca attcttagta 120 taactattgt tgttgtattg atatttatta gtattggtgc tcacaaaaag agtctaaatt 180 ccataagtct ttatattcag gctactcttt atttttgaaa actcattttc tatcaccttt 240 ttctatttta ctccatattg aggcctcata aatccaattt tttatttctt tcttttgtaa 300 atgtggtttc tacaaagatg aaactactaa aacttacagg ttttattttt ttcttgtttt 360 ttttgactga atccctaacc ctgcccacac aacctcggga tatagagaac ttcaatagta 420 ctcaaaaatt tatagaagat aatattgaat acatcaccat cattgcattt gctcagtatg 480 ttcaggaagc aacctttgaa gaaatggaaa agctggtgaa agacatggta gaatacaaag 540 acagatgtat ggctgacaag acgctcccag agtgttcaaa attacctaat aatgttttac 600 aggaaaaaat atgtgctatg gaggggctgc cacaaaagca taatttctca cactgctgca 660 gtaaggttga tgctcaaaga agactctgtt tcttctataa caagaaatct gatgtgggat 720 ttctgcctcc tttccctacc ctggatcccg aagagaaatg ccaggcttat gaaagtaaca 780 gagaatccct tttaaatcac tttttatatg aagttgccag aaggaaccca tttgtcttcg 840 cccctacact tctaactgtt gctgttcatt ttgaggaggt ggccaaatca tgttgtgaag 900 aacaaaacaa agtcaactgc cttcaaacaa gggcaatacc tgtcacacaa tatttaaaag 960 cattttcttc ttatcaaaaa catgtctgtg gggcactttt gaaatttgga accaaagttg 1020 tacactttat atatattgcg atactcagtc aaaaattccc caagattgaa tttaaggagc 1080 ttatttctct tgtagaagat gtttcttcca actatgatgg atgctgtgaa ggggatgttg 1140 tgcagtgcat ccgtgacacg agcaaggtta tgaaccatat ttgttcaaaa caagattcta 1200 tctccagcaa aatcaaagag tgctgtgaaa agaaaatacc agagcgcggc cagtgcataa 1260 ttaactcaaa caaagatgat agaccaaagg atttatctct aagagaagga aaatttactg 1320 acagtgaaaa tgtgtgtcaa gaacgagatg ctgacccaga caccttcttt gcgaagttta 1380 cttttgaata ctcaaggaga catccagacc tgtctatacc agagctttta agaattgttc 1440 aaatatacaa agatctcctg agaaattgct gcaacacaga aaaccctcca ggttgttacc 1500 gttacgcgga agacaaattc aatgagacaa ctgagaaaag cctcaagatg gtacaacaag 1560 aatgtaaaca tttccagaat ttggggaagg atggtttgaa ataccattac ctcatcaggc 1620 tcacgaagat agctccccaa ctctccactg aagaactggt gtctcttggc gagaaaatgg 1680 tgacagcttt cactacttgc tgtacgctaa gtgaagagtt tgcctgtgtt gataatttgg 1740 cagatttagt ttttggagag ttatgtggag taaatgaaaa tcgaactatc aaccctgctg 1800 tggaccactg ctgtaaaaca aactttgcct tcagaaggcc ctgctttgag agtttgaaag 1860 ctgataaaac atatgtgcct ccacctttct ctcaagattt atttaccttt cacgcagaca 1920 tgtgtcaatc tcagaatgag gagcttcaga ggaagacaga caggtttctt gtcaacttag 1980 tgaagctgaa gcatgaactc acagatgaag agctgcagtc tttgtttaca aatttcgcaa 2040 atgtagtgga taagtgctgc aaagcagaga gtcctgaagt ctgctttaat gaagagagtc 2100 caaaaattgg caactgaagc cagctgctgg agatatgtaa agaaaaaagc accaaaggga 2160 aggcttccta tctgtgtggt gatgaatcgc atttcctgag aacaaaataa aaggattttt 2220 ctgtaactgt cacctgaaat aatacattgc agcaagcaat aaacacaaca ttttgtaaag 2280 tt 2282 <210> 106 <211> 1935 <212> DNA <213> Homo sapiens <220> <223> Genbank Accession No. M10943 <400> 106 tctagacagt ggcgcaagag actggggttg cactgggact ccaggaaagg cttagctgtt 60 gacgaaggac cggggcgggg ccggggggcg gggcgaaggc caggatctcc aggtacccgg 120 aaccccaagg ggcgggtgta gcaggcaatc ttggcgaaac tgggaagggc gggcaggagg 180 gcagggaagc cgctcaccca ggcacaaagc gcctcccgct tgagcggact ccaaagggac 240 ggtccgcggt gtgcagcgag ctgcgctcag gggaccttgc gcccggccct tctgctgcac 300 acagcccacc caggacctcc cgcagcgctg acaggcgggg cgggtgcaaa gacggggcgg 360 ggtctctgcg cccggccccc tcccctgact atcaaagcag cggccggctg tttgggtcca 420 ccacgccttc cacctgcccc actgcttctt cgcttctctc ttggaaagtc cagtctctcc 480 tcggcttgca atggacccca actgctcctg cgccgctggt aaggaacgcc gggttccgtg 540 cctggggatg ctcgattccc agacaccata gagagtgttc ctgggtttga gaaggtcgta 600 ttttgagatc tcaactgtag gggactcctt gacttagtcc agtgctttcc tcttggccaa 660 gatcctgaga gcatttcctt cctctctgtg cctctgtgtc agcgttgagg gtactgaggc 720 tcaaggctgt cctgctccac gtcatgcggt ttgtcccagg gctgttggct gagccccagt 780 gctctgacca ggctttgagc agcaggatta gataggaggc aggggacatt gcctcttcgg 840 ggttcaggac agaaagtcga agtcgccgtc ttcccaggct gtgcctggag cctgggactt 900 tcctttggag tgcaaacagg aggctgcttg gccttcccag catgaaggga gaggacatgg 960 ggcttctctt cctctgctct gagtgggaaa ggagctctga gggctggccc cgcacagagg 1020 agggggcaat ggagactcat taactcactg ctgtacctcc tgcaggtcac tcgccgctca 1080 ctggcttttt tttctctttc tcgcaggtgt ctcctgcacc tgcgctggtt cctgcaagtg 1140 caaagagtgc aaatgcacct cctgcaagaa gagtgagtgt gaggccatct ccatggtctg 1200 gggctgtggc taaggttggg atggaaccca aggctggccc tgagtgcatg cttctgggga 1260 actggccttc ctttgtcccc gtaggttgtc actgcctttc tagtcttctg ccctgtgcag 1320 ggcgcctggg cagctttctc ataggaagac ccaccccaga tatttcccag ttgtctcctg 1380 acaaagccat accctcctga actgagggtc ctttgtggct ggaggctctg ttgggggcct 1440 ctgttgggga gggaggtccc tgggcaagtt ggctgtgacc tctcatgctc ctcttcttcc 1500 ccaggctgct gctcctgctg ccccgtgggc tgtagcaagt gtgcccaggg ctgtgtttgc 1560 aaaggggcgt cagagaagtg cagctgctgc gactgatgcc aggacaacct ttctcccaga 1620 tgtaaacaga gagacatgta caaacctgga tttttttttt ataccacctt gacccatttg 1680 ctacattcct tttcctgtga aatatgtgag tgataattaa acactttaga cctgattctg 1740 acttcagttt cccttatgtg cttcagaaat cagagactgg ggtgggggat cgaactaggg 1800 ttgcagactc ctgggctcta aatggaaatc tgagtcccta acaatcagag tgcattaagg 1860 caagccaggc tgcctcactg tgcttcctct tctgtagaat ggaataacac ttcatcaggt 1920 cattggtggg gatcc 1935 <210> 107 <211> 2532 <212> DNA <213> Homo sapiens <220> <223> Genbank Accession No. X03350 <400> 107 agtgcactca agcagagaag aaatccacaa agactcacca gtctgctggt gggcagagaa 60 gacagaaacg acatgagcac agcaggaaaa gtaatcaaat gcaaagcagc tgtgctatgg 120 gaggtaaaga aacccttttc cattgaggat gtggaggttg cacctcctaa ggcttatgaa 180 gttcgcatta agatggtggc tgtaggaatc tgtcgcacag atgaccacgt ggttagtggc 240 aacctggtga ccccccttcc tgtgatttta ggccatgagg cagccggcat cgtggagagt 300 gttggagaag gggtgactac agtcaaacca ggtgataaag tcatcccgct ctttactcct 360 cagtgtggaa aatgcagagt ttgtaaaaac ccggagagca actactgctt gaaaaatgat 420 ctaggcaatc ctcgggggac cctgcaggat ggcaccagga ggttcacctg cagggggaag 480 cccattcacc acttccttgg caccagcacc ttctcccagt acacggtggt ggatgagaat 540 gcagtggcca aaattgatgc agcctcgccc ctggagaaag tctgcctcat tggctgtgga 600 ttctcgactg gttatgggtc tgcagttaac gttgccaagg tcaccccagg ctctacctgt 660 gctgtgtttg gcctgggagg ggtcggccta tctgctgtta tgggctgtaa agcagctgga 720 gcagccagaa tcattgcggt ggacatcaac aaggacaaat ttgcaaaggc caaagagttg 780 ggtgccactg aatgcatcaa ccctcaagac tacaagaaac ccatccagga agtgctaaag 840 gaaatgactg atggaggtgt ggatttttcg tttgaagtca tcggtcggct tgacaccatg 900 atggcttccc tgttatgttg tcatgaggca tgtggcacaa gcgtcatcgt aggggtacct 960 cctgcttccc agaacctctc aataaaccct atgctgctac tgactggacg cacctggaag 1020 ggggctgttt atggtggctt taagagtaaa gaaggtatcc caaaacttgt ggctgatttt 1080 atggctaaga agttttcact ggatgcgtta ataacccatg ttttaccttt tgaaaaaata 1140 aatgaaggat ttgacctgct tcactctggg aaaagtatcc gtaccgtcct gacgttttga 1200 ggcaatagag atgccttccc ctgtagcagt cttcagcctc ctctacccta cgagatctgg 1260 agcaacagct aggaaatatc attaattcag ctcttcagag atgttatcaa taaattacac 1320 atgggggctt tccaaagaaa tggaaattga tgggaaatta tttttcagga aaatttaaaa 1380 ttcaagtcag aagtaaataa agtgttgaac atcagctggg gaattgaagc caacaaacct 1440 tccttcttaa ccattctact gtgtcacctt tgccattgag gaaaaatatt cctgtgactt 1500 cttgcatttt tggtatcttc ataatcttta gtcatcgaat cccagtggag gggacccttt 1560 tacttgccct gaacatacac atgctgggcc attgtgattg aagtcttcta actctgtctc 1620 agttttcact gtcgacattt tcctttttct aataaaaatg taccaaatcc ctggggtaaa 1680 agctagggta aggtaaagga tagactcaca tttacaagta gtgaaggtcc aagagttcta 1740 aatacaggaa atttcttagg aactcaaata aaatgcccac attttactac agtaaatggc 1800 agtgttttta tgacttttat actatttctt tatggtcgat atacaattga ttttttaaaa 1860 taatagcaga tttcttgctt catatgacaa agcctcaatt actaattgta aaaactgaac 1920 tattcccaga atcatgttca aaaaatctgt aattttgctg atgaaagtgc ttcattgact 1980 aaacagtatt agtttgtggc tataaatgat tatttaggat gatgactgaa aatgtgtata 2040 agtaattaaa agtaatatgg tggctttaag tgtagagatg ggatggcaaa tgctgtgaat 2100 gcagaatgta aaattggtaa ctaagaaatg gcacaaacac cttaagcaat atattttcct 2160 agtagatata tatatacaca tacatatata cacatataca aatgtatatt tttgcaaaat 2220 tgttttcaat ctagaacttt tctattaact accatgtctt aaaatcaagt ctataatcct 2280 agcattagtt taatattttg aatatgtaaa gacctgtgtt aatgctttgt taatgctttt 2340 cccactctca tttgttaatg ctttcccact ctcaggggaa ggatttgcat tttgagcttt 2400 atctctaaat gtgacatgca aagattattc ctggtaaagg aggtagctgt ctccaaaaat 2460 gctattgttg caatatctac attctatttc atattatgaa agaccttaga cataaagtaa 2520 aatagtttat ca 2532 <210> 108 <211> 3890 <212> DNA <213> Homo sapiens <220> <223> Genbank Accession No. J03507 <400> 108 atgaaggtga taagcttatt cattttggtg ggatttatag gagagttcca aagtttttca 60 agtgcctcct ctccagtcaa ctgccagtgg gacttctatg ccccttggtc agaatgcaat 120 ggctgtacca agactcagac tcgcaggcgg tcagttgctg tgtatgggca gtatggaggc 180 cagccttgtg ttggaaatgc ttttgaaaca cagtcctgtg aacctacaag aggatgtcca 240 acagaggagg gatgtggaga gcgtttcagg tgcttttcag gtcagtgcat cagcaaatca 300 ttggtttgca atggggattc tgactgtgat gaagacagtg ctgatgaaga cagatgtgag 360 gactcagaaa ggagaccttc ctgtgatatc gataaacctc ctcctaacat agaacttact 420 ggaaatggtt acaatgaact cactggccag tttaggaaca gagtcatcaa taccaaaagt 480 tttggtggtc aatgtagaaa ggtgtttagt ggggatggaa aagatttcta caggctgagt 540 ggaaatgtcc tgtcctatac attccaggtg aaaataaata atgattttaa ttatgaattt 600 tacaatagta cttggtctta tgtaaaacat acgtcgacag aacacacatc atctagtcgg 660 aagcgctcct tttttagatc ttcatcatct tcttcacgca gttatacttc acataccaat 720 gaaatccata aaggaaagag ttaccaactg ctggttgttg agaacactgt tgaagtggct 780 cagttcatta ataacaatcc agaattttta caacttgctg agccattctg gaaggagctt 840 tcccacctcc cctctctgta tgactacagt gcctaccgaa gattaatcga ccagtacggg 900 acacattatc tgcaatctgg gtcgttagga ggagaataca gagttctatt ttatgtggac 960 tcagaaaaat taaaacaaaa tgattttaat tcagtcgaag aaaagaaatg taaatcctca 1020 ggttggcatt ttgtcgttaa attttcaagt catggatgca aggaactgga aaacgcttta 1080 aaagctgctt caggaaccca gaacaatgta ttgcgaggag aaccgttcat cagaggggga 1140 ggtgcaggct tcatatctgg ccttagttac ctagagctgg acaatcctgc tggaaacaaa 1200 aggcgatatt ctgcctgggc agaatctgtg actaatcttc ctcaagtcat aaaacaaaag 1260 ctgacacctt tatatgagct ggtaaaggaa gtaccttgtg cctctgtgaa aaaactatac 1320 ctgaaatggg ctcttgaaga gtatctggat gaatttgacc cctgtcattg ccggccttgt 1380 caaaatggtg gtttggctac tgttgagggg acccattgtc tgtgccattg caaaccgtac 1440 acatttggtg cggcgtgtga gcaaggagtc ctcgtaggga atcaagcagg aggggttgat 1500 ggaggttgga gttgctggtc ctcttggagc ccctgtgtcc aagggaagaa aacaagaagc 1560 cgtgaatgca ataacccacc tcccagtggg ggtgggagat cctgcgttgg agaaacgaca 1620 gaaagcacac aatgcgaaga tgaggagctg gagcacttga ggttgcttga accacattgc 1680 tttcctttgt ctttggttcc aacagaattc tgtccatcac ctcctgcctt gaaagatgga 1740 tttgttcaag atgaaggtcc aatgtttcct gtggggaaaa atgtagtgta cacttgcaat 1800 gaaggatact ctcttattgg aaacccagtg gccagatgtg gagaagattt acggtggctt 1860 gttggggaaa tgcattgtca gaaaattgcc tgtgttctac ctgtactgat ggatggcata 1920 cagagtcacc cccaaaaacc tttctacaca gttggtgaga aggtgactgt ttcctgttca 1980 ggtggcatgt ccttagaagg tccttcagca tttctctgtg gctccagcct taagtggagt 2040 cctgagatga agaatgcccg ctgtgtacaa aaagaaaatc cgttaacaca ggcagtgcct 2100 aaatgtcagc gctgggagaa actgcagaat tcaagatgtg tttgtaaaat gccctacgaa 2160 tgtggacctt ccttggatgt atgtgctcaa gatgagagaa gcaaaaggat actgcctctg 2220 acagtttgca agatgcatgt tctccactgt cagggtagaa attacaccct tactggtagg 2280 gacagctgta ctctgcctgc ctcagctgag aaagcttgtg gtgcctgccc actgtgggga 2340 aaatgtgatg ctgagagcag caaatgtgtc tgccgagaag catcggagtg cgaggaagaa 2400 gggtttagca tttgtgtgga agtgaacggc aaggagcaga cgatgtctga gtgtgaggcg 2460 ggcgctctga gatgcagagg gcagagcatc tctgtcacca gcataaggcc ttgtgctgcg 2520 gaaacccagt aggctcctgg aggccatggt cagcttgctt ggaatccagc aggcagctgg 2580 ggctgagtga aaacatctgc acaactgggc actggacagc ttttccttct tctccagtgt 2640 ctaccttcct cctcaactcc cagccatctg tataaacaca atcctttgtt ctcccaaatc 2700 tgaatcgaat tactcttttg cctccttttt aatgtcagta aggatatgag cctttgcaca 2760 ggctggctgc gtgttcttga aataggtgtt accttctctg ggccttggtt ttttaaaatc 2820 tgtaaaatta gaggattgca ctagagaaac ttgaatgctc cattcaggcc tatcatttta 2880 ttaagtatga ttgacacagc ccatgggcca gaacacactc tacaaaatga ctaggataac 2940 agaaagaacg tgatctcctg attagagagg gtggttttcc tcaatggaac caaatataaa 3000 gaggacttga acaaaaatga cagatacaaa ctatttctat cctgagtagt aatctcacac 3060 ttcatcctat agagtcaacc accacagata ggaattcctt attctttttt taattttttt 3120 aagacagagt ctcactttgt tgcccaggct ggagcgcagt ggggtgatct catctccctg 3180 caacctccgc ctcctgggtt gaagcgattc ttgtgcctca gcttcccaag cagctgggat 3240 tacaggtgcc cgccaccacg cccagctaat ttttgcattt ttagtagaga tgggtttcac 3300 catgttggcc atgctcgtct ccaactcctg acctcaggta atccgtctgc cttggcctcc 3360 caaatgctgg gattacagac atgaaccacc acgcctggct ggaatactta ctcttgtcgg 3420 gagattgaac cactaaaatg ttagagcaga attcattatg ctgtggtcac aggggtgtct 3480 tgtctgagaa caaatacaat tcagtcttct ctttggggtt ttagtatgtg tcaaacatag 3540 gactggaagt ttgcccctgt tcttttttct tttgaaagaa catcagttca tgcctgaggc 3600 atgagtgact gtgcatttga gatagttttc cctattctgt ggatacagtc ccagagtttt 3660 cagggagtac acaggtagat tagtttgaag cattgacctt ttatttattc cttatttctc 3720 tttcatcaaa acaaaacagc agctgtggga ggagaaatga gagggcttaa atgaaattta 3780 aaataagcta tattatacaa atactatctc tgtattgttc tgaccctggt aaatatattt 3840 caaaacttca gatgacaagg attagaacac tcattaagat gctattcttc 3890 <210> 109 <211> 2941 <212> DNA <213> Homo sapiens <220> <223> Genbank Accession No. K01383 <400> 109 gaattcatgc ttggactaca gcttcccgcc acctccccca tcttgctttt tagtttaaag 60 cagggtcagc acatcacatg aagtcatctc ctttttaggg gatatcccac atgccaagac 120 taccaagcgg taggggggtg gccggctagg ctgtggggag cacggagatt tatttgcaaa 180 ggaggaccta gacaaaagag cccccacatc ctctcaggcg aggagaatgg acgagagtga 240 gaggccgacc cgtgttcccg tgttactgtg tacggagtag tgggtccgag ggacctaggt 300 gtggacaggg acaggcaagg cgacagcgag gagaaacgaa aatcacatcg gtggcggttg 360 ctctgcacac aaactccgct cgctaccgca cgctccacgc tctgcactac gccgaccggg 420 gacaggagca ggaggctgtg gctgcactca gacttcggga caggccgagc tgaaaaccgt 480 gagaggggtg gggtggaggc gaccgaaacg ccaaggctgg gttcccggaa cgcgcgggga 540 ccagggtgga aggcaacttc ggggaaacgg gaaaggcgac cgggacctcg gggacgcccc 600 gtaccccggg cgtaaactca ctcccgcgtt agcgggcgcc aaagcgggga gggggtggtc 660 ccgtggtccg cacccagggg agctcagtgg actgtgcgcc ttgcctttct gctgcgcaaa 720 gcccagtcca ggtcatcacc tcgggcgggg cggactcggc tgggcggact cagcggggcg 780 ggcgcaggcg cagggcgggt cctttgcgtc cggccctctt tcccctgacc ataaaagcag 840 ccgctggctg ctgggcccta ccaagccttc cacgtgcgcc ttatagcctc tcaacttctt 900 gcttgggatc tccaacctca ccgcggctcg aaatggaccc caactgctcc tgcgccactg 960 gtaagggatg ctaggtttct ggtccttagg atacctattt ccccgccaca ggatagatgt 1020 ccctaggagt agaggtgttt tttgagttct agctaagtgg agtcatttat ttcattgatc 1080 tagtgctttt ccactcagcg ccttcatcat ccctagaaca ttcctattct aatgcctccc 1140 atttcgagag gcgagaggac tcaggctcat aattctcctg ctccatgtca cccaggtagt 1200 cggggactgc tagctgagcc ccagtactct gcgcagttcc tgggcggatg ggcgacacgg 1260 acttattggt ttttcgggat taaggacata agcccatcct agcctctaca gatagaagta 1320 agattagctt catgtgccct gagttggaca ggagctatct atcaggcctg gcaatgcact 1380 cagctggcag catttgttga ccaactgctg ttatcttctg tgtaaagttc actgcctttt 1440 tctcttcctt gcaggtggct cctgcacctg cactggctcc tgcaaatgca aagagtgcaa 1500 atgcaactcc tgcaagaaga gtgagtgcgg ggccatctct aggaactggg gctgagccaa 1560 gtcagaggca ggaaaccaga gctgggctag gaggagtagg ccaatgatcc atttcccaca 1620 tcccttccca gcaactgatt caggatcaga gccagatctt tagacgtgat ggattcccaa 1680 gtttcgttct taaaatagac aaactgaggc caagagagtg caccaaccta ccaaacacaa 1740 acatgacacc taaggacttt cctcccctaa gtgtgtggtt ctggggagcc agccttcctt 1800 tgtccttcta accccagtca ctgcctttcc agccttctgc caggtctggg gctcagatgg 1860 agataagctt ttcacagaag accctcactc gaaagatcca ccacttatct cccatctccg 1920 acagtgcatg ccatcctgaa ctaagtgtcc tctggggctg gggacagagc ttgggccagg 1980 cttctctggg ggcagggaag tcccggtcaa gtctagtctg acctctcact ctcccttctt 2040 ccccaggctg ctgctcctgc tgccccatga gctgtgccaa gtgtgcccag ggctgcatat 2100 gcaaaggggc atcagagaag tgcagctgct gtgcctgatg tccggacagc cctgctcgaa 2160 gatatagaaa gagtgacctg cacaaacttg gaattttttt tccatacaac cctgacccat 2220 ttactgtatt ttttttaatg aaatatgtga atgataataa aagttgctga cttaatgctg 2280 gctctggttt tctttgtgtg ccttgaaata agggaccata caacagagct gggatggtgg 2340 attgcattga gagtcagaga cctgggtgct gggaccttgt gctattatct tacacactgg 2400 aggcctgtta aggcaaatca ggtactcgcc tcaggtcagt ttcttaaata aaaatgtaag 2460 agcgtgatga cagatgatat aatgccacag gaatctgtca cagacttaag ctttggtaag 2520 ataaaatcta ttagtatgac aaaaaaaaac accaaatcca ttttttatat tgaacaggac 2580 aatttcagta aatatatgga agacaagata ggaaaaataa aattacacta cacatttgtt 2640 ctggatgtat attcagactt ggaaacagtt cacagactgg ccccagtatg tgggtcacac 2700 accttcaaca ccagccaaga catccccaca tggaaccatc agtcttggcc tgtccaggtc 2760 actgatgtga tacttggtat ctctgagagc tccatgttgt gacttgtctc tgaatcttcg 2820 gaagtttctc cctaggtcat gctgaaatcc gttcctcctc aagtccagcc cttggttaat 2880 tcaggcaagc aaagtgactg ggggagtggg ggaaattacc caggatcctc ccagcaagct 2940 g 2941

Claims (42)

  1. (a) 조직 샘플에서 표 1의 하나 또는 그 이상의 유전자들의 발현 레벨을 탐지하고; 여기에서 표 1의 유전자들의 차등 발현은 간암을 나타내는 것을 포함하는 것으로 구성되어 있는 환자에 있어서 간암을 진단하는 방법.
  2. (a) 조직 샘플에서 표 1의 하나 또는 그 이상의 유전자들의 발현 레벨을 탐지하고; 여기에서 표 1의 유전자들의 차등 발현은 간암을 나타내는 것을 포함하는 것으로 구성되어 있는 환자에 있어서 간암의 진행을 탐지하는 방법.
  3. (a) 약제 조성물을 환자에게 투여하고;
    (b) 환자의 조직과 세포로부터의 표 1의 하나 또는 그 이상의 유전자 발현 프로파일을 준비하고; 및
    (c) 환자의 유전자 발현 프로파일을, 비암화 간 세포들 및 암화 간 세포들로 구성된 군으로부터 선택된 세포 군집으로부터의 유전자 발현 프로파일을 비교하는 것;
    을 포함하는 것으로 구성된 간암 환자의 치료를 모니터링하는 방법.
  4. (a) 약제 조성물을 환자에게 투여하고;
    (b) 환자의 조직과 세포로부터의 표 1의 하나 또는 그 이상의 유전자 발현프로파일을 준비하고; 및
    (c) 환자의 유전자 발현 프로파일을, 비암화 간 세포들 및 암화 간 세포로 구성된 군으로부터 선택된 유전자 발현 프로파일을 비교하는 것;
    을 포함하는 것으로 구성된 간암 환자를 치료하는 방법.
  5. 조직 샘플에서 표 1의 중 하나 또는 그 이상의 유전자들의 발현 레벨을 탐지하며, 여기서, 표 1의 유전자들 차등 발현은, 간암 발암성을 가진 만성 간염 및 간암 발암성을 가진 간 경과로 이루어진 군에서 선택된 간 질환의 한 유형임을 나타내는 것을 포함하는 것으로 구성된, 환자에 있어서 간 질환을 종류화하는 방법.
  6. 조직 샘플에서 표 1의 중 하나 또는 그 이상의 유전자들의 발현 레벨을 탐지하며, 여기서, 표 1의 유전자들 차등 발현은 간암을 가진 만성 간염을 나타내는 것임을 포함하는 것으로 구성된, 만성 간염 환자에게서 간암의 존재 또는 진행을 탐지하는 방법.
  7. 조직 샘플에서 표 1의 하나 또는 그 이상의 유전자들의 발현 레벨을 탐색하며, 여기서, 표 1의 유전자들의 차등 발현은 간암을 가진 간 경화를 나타낸 것임을 포함하는 것으로 구성된, 간 경화 환자에게서 간암의 존재 또는 진행을 탐지하는 방법.
  8. 제 1 항에 있어서, 상기 간암은 만성 간염 또는 간 경화에 의해 수반되는 것인 방법.
  9. 조직 샘플에서 표 1의 하나 또는 그 이상의 유전자들의 발현 레벨을 탐색하며, 여기서, 표 1의 유전자들의 차등 발현은 만성 간염에 관련된 간암 또는 간 경화에 관련된 간암을 나타낸 것임을 포함하는 것으로 구성된, 환자에게서 만성 간염에 관련된 간암을 간 경화에 관련된 간암으로부터 차별화시키는 방법.
  10. (a) 암화 간 세포들을 포함하는 것으로 구성된 세포 군집의 제 1 유전자 발현 프로파일을 준비하는 하는 것으로서, 상기 발현 프로파일은 표 1의 하나 또는 그 이상의 유전자 발현 레벨을 포함하는 것으로 구성되어 있고;
    (b) 세포 군집을 작용제에 노출시키며;
    (c) 작용제에 노출시킨 세포 집단으로부터 제 2 유전자 발현 프로파일을 준비하고; 및
    (d) 제 1 및 제 2 유전자 발현 프로파일들을 비교하는 것;
    을 포함하는 것으로 구성되어 있는, 간암의 개시 및 진행을 조절할 수 있는 작용제를 스크리닝하는 방법.
  11. 제 10 항에 있어서, 간암은 간암을 가진 만성 간염인 방법.
  12. 제 10 항에 있어서, 간 질환은 간암을 가진 간 경화인 방법.
  13. 각각의 올리고뉴클레오티드가 표 1의 유전자와 특이적으로 혼성화를 이루는 서열을 포함하는 것으로 구성되어 있는, 적어도 두 개의 올리고뉴클레오티드를 포함하는 것으로 구성되어 있는 조성물.
  14. 제 13 항에 있어서, 상기 조성물은 적어도 3 개의 올리고뉴클레오티드를 포함하는 것으로 구성되어 있는 조성물.
  15. 제 13 항에 있어서, 상기 조성물은 적어도 5 개의 올리고뉴클레오티드를 포함하는 것으로 구성되어 있는 조성물.
  16. 제 13 항에 있어서, 상기 조성물은 적어도 7 개의 올리고뉴클레오티드를 포함하는 것으로 구성되어 있는 조성물.
  17. 제 13 항에 있어서, 상기 조성물은 적어도 10 개의 올리고뉴클레오티드를 포함하는 것으로 구성되어 있는 조성물.
  18. 제 13 항 내지 제 17 항 중 어느 한 항에 있어서, 상기 올리고뉴클레오티드는 고체 지지체에 부착되어 있는 조성물.
  19. 제 18 항에 있어서, 상기 고체 지지체는 멤브레인, 유리 지지체, 필터, 조직 배양 용기, 고분자 재질, 비드 및 실리카 지지체로 이루어진 군으로부터 선택되는 조성물.
  20. 각각의 올리고뉴클레오티드가 표 1의 유전자와 특이적으로 혼성화를 이루는 서열을 포함하는 것으로 구성되어 있는, 적어도 두 개의 올리고뉴클레오티드로 구성되어 있는 고체 지지체.
  21. 제 20 항에 있어서, 상기 올리고뉴클레오티드는 고체 지지체에 공유적으로 부착되어 있는 고체 지지체.
  22. 제 20 항에 있어서, 상기 올리고뉴클레오티드는 고체 지지체에 비공유적으로 부착되어 있는 고체 지지체.
  23. 제 20 항에 있어서, 상기 지지체는 제곱 센티미터당 분별적인 위치에서 적어도 약 10 개의 올리고뉴클레오티드를 포함하는 것으로 구성되어 있는 고체 지지체.
  24. 제 20 항에 있어서, 상기 지지체는 제곱 센티미터당 분별적인 위치에서 적어도 약 100 개의 올리고뉴클레오티드를 포함하는 것으로 구성되어 있는 고체 지지체.
  25. 제 20 항에 있어서, 상기 지지체는 제곱 센티미터당 분별적인 위치에서 적어도 약 1000 개의 올리고뉴클레오티드를 포함하는 것으로 구성되어 있는 고체 지지체.
  26. 제 20 항에 있어서, 상기 지지체는 제곱 센티미터당 분별적인 위치에서 적어도 약 10,000 개의 올리고뉴클레오티드를 포함하는 것으로 구성되어 있는 고체 지지체.
  27. (a) 표 1의 적어도 하나의 유전자를 포함하는 것으로 구성되어 있는 유전자 셋트의 간 조직에서 발현 수준을 확인하는 정보를 포함하고 있는 데이터베이스; 및
    (b) 상기의 정보를 보기 위한 사용자 인터페이스;
    를 포함하는 것으로 구성되어 있는 컴퓨터 시스템.
  28. 제 27 항에 있어서, 상기 데이터베이스는 유전자들에 관한 서열 정보를 더 포함하고 있는 컴퓨터 시스템.
  29. 제 27 항에 있어서, 상기 데이터베이스는 정상 간 조직에서의 유전자들의 발현 레벨를 확인하는 정보를 더 포함하는 것으로 구성되어 있는 컴퓨터 시스템.
  30. 제 27 항에 있어서, 상기 데이터베이스는 간 종양으로부터의 조직에서 발현 레벨을 확인하는 정보를 더 포함하는 것으로 구성되어 있는 컴퓨터시스템.
  31. 제 30 항에 있어서, 상기 간 종양은 만성 간염 환자로부터 얻어진 컴퓨터시스템.
  32. 제 30 항에 있어서, 상기 간 종양은 간 경화 환자로부터 얻어진 컴퓨터시스템.
  33. 제 27 항 내지 제 32 항 중 어느 한 항에 있어서, 외부 데이터베이스로부터의 기술적(descriptive) 정보를 포함하고 있는 기록들을 더 포함하는 것으로 구성되어 있고, 상기 정보는 외부 데이터베이스의 정보에 상기 유전자들을 연관시키는 컴퓨터 시스템.
  34. 제 33 항에 있어서, 상기 외부 데이터베이스는 GeneBank인 컴퓨터 시스템.
  35. 조직 또는 세포에서의 표 1의 적어도 하나의 유전자의 발현 레벨을 데이터베이스의 유전자의 발현 레벨을 비교하는 것을 포함하는 것으로 구성된, 조직 또는 세포에서 표 1의 적어도 하나의 유전자의 발현 레벨을 확인하는 정보를 제공하기위하여, 제 27 항 내지 제 34 항 중 어느 한 항에 따른 컴퓨터 시스템을 사용하는 방법.
  36. 제 35 항에 있어서, 적어도 2 개의 유전자의 발현 레벨이 비교되는 방법.
  37. 제 35 항에 있어서, 적어도 5 개의 유전자의 발현 레벨이 비교되는 방법.
  38. 제 35 항에 있어서, 적어도 10 개의 유전자의 발현 레벨이 비교되는 방법.
  39. 제 35 항에 있어서, 간 질환에서의 발현 레벨과 비교하여, 조직과 세포 샘플의 적어도 하나의 유전자의 발현 레벨을 표시하는 것을 더 포함하는 방법.
  40. 제 39 항에 있어서, 상기 간 질환은 간암, 만성 간염 또는 간 경화인 방법.
  41. 표 1의 유전자들, 표 1의 유전자들의 기능성 단편들, 표 1의 유전자들에 의해 암호화되는 단백질, 및 상기 단백질의 기능성 단편들로 이루어진 군으로부터 선택되며, 간암의 진행을 느리게 하거나 중단시키기 위한 치료제.
  42. 표 1의 적어도 하나의 유전자의 전부 또는 일부, 또는 거기서 암호화된 단백질을 포함하는 것으로 구성되어 있는 약제 단백질을 간암 환자에게 투여하는 것을포함하는 것으로 구성되어 있는, 간암 환자를 치료하는 방법.
KR10-2004-7009882A 2001-12-21 2002-12-20 간 질환에서의 유전자 발현 프로파일 KR20040101992A (ko)

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US60/343,185 2001-12-31
PCT/US2002/040718 WO2003061564A2 (en) 2001-12-21 2002-12-20 Gene expression profiles in liver disease

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100964193B1 (ko) * 2009-04-17 2010-06-16 씨비에스바이오사이언스 주식회사 간암 예후 마커

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7473528B2 (en) 1999-01-06 2009-01-06 Genenews Inc. Method for the detection of Chagas disease related gene transcripts in blood
WO2006008003A2 (en) * 2004-07-23 2006-01-26 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with vasoactive intestinal peptide receptor 1 (vpac1)
CA2586201A1 (en) * 2004-11-03 2006-05-11 Almac Diagnostics Limited Transcriptome microarray technology and methods of using the same
WO2007137187A2 (en) * 2006-05-18 2007-11-29 Molecular Profiling Institute, Inc. System and method for determining individualized medical intervention for a disease state
JP5028615B2 (ja) * 2006-05-24 2012-09-19 国立大学法人金沢大学 遺伝子発現プロファイルによるｃ型肝硬変及び肝癌の検出
KR100767878B1 (ko) * 2006-11-07 2007-10-17 전북대학교산학협력단 간세포암 진단용 조성물, 이를 포함하는 간세포암 진단키트 및 간세포암 진단방법
CN101587125B (zh) * 2008-05-21 2013-07-24 林标扬 高表达癌症标记物和低表达组织器官标记物组合试剂盒
WO2010127417A2 (en) * 2009-05-05 2010-11-11 Katholieke Universiteit Leuven Hepatocellular carcinoma
WO2010138826A1 (en) * 2009-05-29 2010-12-02 University Of Utah Research Foundation Methods and compositions related to cellular assays
US20130295666A1 (en) * 2011-12-22 2013-11-07 Boehringer Ingelheim International Gmbh Crystals of glucokinase regulatory protein (gkrp)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002209591A (ja) * 2001-01-19 2002-07-30 Japan Science & Technology Corp ヒト肝疾患発現遺伝子群
AU2002362646A1 (en) * 2001-10-09 2003-04-22 The Johns Hopkins University A phosphatase associated with metastasis

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100964193B1 (ko) * 2009-04-17 2010-06-16 씨비에스바이오사이언스 주식회사 간암 예후 마커
WO2010120143A3 (ko) * 2009-04-17 2011-05-26 씨비에스바이오사이언스 주식회사 간암 예후 마커
CN102428184A (zh) * 2009-04-17 2012-04-25 Cbs生物科学有限公司 肝癌预后标记物

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