KR20040071089A - Cultivation of mulberry tree containing selenium and germanium - Google Patents
Cultivation of mulberry tree containing selenium and germanium Download PDFInfo
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- KR20040071089A KR20040071089A KR1020040052487A KR20040052487A KR20040071089A KR 20040071089 A KR20040071089 A KR 20040071089A KR 1020040052487 A KR1020040052487 A KR 1020040052487A KR 20040052487 A KR20040052487 A KR 20040052487A KR 20040071089 A KR20040071089 A KR 20040071089A
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- selenium
- germanium
- mulberry
- mulberry tree
- yeast complex
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- 239000011669 selenium Substances 0.000 title claims abstract description 63
- 229910052711 selenium Inorganic materials 0.000 title claims abstract description 62
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 title claims abstract description 61
- 240000000249 Morus alba Species 0.000 title claims abstract description 41
- 235000008708 Morus alba Nutrition 0.000 title claims abstract description 41
- GNPVGFCGXDBREM-UHFFFAOYSA-N germanium atom Chemical compound [Ge] GNPVGFCGXDBREM-UHFFFAOYSA-N 0.000 title claims description 78
- 229910052732 germanium Inorganic materials 0.000 title claims description 74
- 238000000034 method Methods 0.000 claims abstract description 10
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- 235000013305 food Nutrition 0.000 claims abstract description 5
- 229910003424 Na2SeO3 Inorganic materials 0.000 claims abstract 4
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- 235000018716 sodium selenate Nutrition 0.000 claims abstract 4
- 239000011655 sodium selenate Substances 0.000 claims abstract 4
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- 239000011781 sodium selenite Substances 0.000 claims abstract 4
- 240000007594 Oryza sativa Species 0.000 claims abstract 3
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- 239000003814 drug Substances 0.000 description 3
- YBMRDBCBODYGJE-UHFFFAOYSA-N germanium oxide Inorganic materials O=[Ge]=O YBMRDBCBODYGJE-UHFFFAOYSA-N 0.000 description 3
- 229910001385 heavy metal Inorganic materials 0.000 description 3
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- FDKWRPBBCBCIGA-REOHCLBHSA-N (2r)-2-azaniumyl-3-$l^{1}-selanylpropanoate Chemical compound [Se]C[C@H](N)C(O)=O FDKWRPBBCBCIGA-REOHCLBHSA-N 0.000 description 1
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- FDKWRPBBCBCIGA-UWTATZPHSA-N D-Selenocysteine Natural products [Se]C[C@@H](N)C(O)=O FDKWRPBBCBCIGA-UWTATZPHSA-N 0.000 description 1
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- 206010037660 Pyrexia Diseases 0.000 description 1
- 241000607142 Salmonella Species 0.000 description 1
- 206010039921 Selenium deficiency Diseases 0.000 description 1
- RJFAYQIBOAGBLC-BYPYZUCNSA-N Selenium-L-methionine Chemical compound C[Se]CC[C@H](N)C(O)=O RJFAYQIBOAGBLC-BYPYZUCNSA-N 0.000 description 1
- RJFAYQIBOAGBLC-UHFFFAOYSA-N Selenomethionine Natural products C[Se]CCC(N)C(O)=O RJFAYQIBOAGBLC-UHFFFAOYSA-N 0.000 description 1
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- 229940041181 antineoplastic drug Drugs 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
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- 229910052800 carbon group element Inorganic materials 0.000 description 1
- 150000001724 carbon group elements Chemical class 0.000 description 1
- 231100000357 carcinogen Toxicity 0.000 description 1
- 239000003183 carcinogenic agent Substances 0.000 description 1
- 230000019522 cellular metabolic process Effects 0.000 description 1
- 210000003483 chromatin Anatomy 0.000 description 1
- 230000007882 cirrhosis Effects 0.000 description 1
- 208000019425 cirrhosis of liver Diseases 0.000 description 1
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- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 235000015203 fruit juice Nutrition 0.000 description 1
- -1 germanium Chemical class 0.000 description 1
- 230000004217 heart function Effects 0.000 description 1
- 208000010501 heavy metal poisoning Diseases 0.000 description 1
- 210000000003 hoof Anatomy 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
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- 230000004199 lung function Effects 0.000 description 1
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- 235000013372 meat Nutrition 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
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- 229960005181 morphine Drugs 0.000 description 1
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- 238000002703 mutagenesis Methods 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 229940012843 omega-3 fatty acid Drugs 0.000 description 1
- 235000020660 omega-3 fatty acid Nutrition 0.000 description 1
- 239000006014 omega-3 oil Substances 0.000 description 1
- 238000011275 oncology therapy Methods 0.000 description 1
- 150000002894 organic compounds Chemical class 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 125000000082 organogermanium group Chemical group 0.000 description 1
- PVADDRMAFCOOPC-UHFFFAOYSA-N oxogermanium Chemical compound [Ge]=O PVADDRMAFCOOPC-UHFFFAOYSA-N 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 230000000737 periodic effect Effects 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
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- 230000001105 regulatory effect Effects 0.000 description 1
- ZKZBPNGNEQAJSX-UHFFFAOYSA-N selenocysteine Natural products [SeH]CC(N)C(O)=O ZKZBPNGNEQAJSX-UHFFFAOYSA-N 0.000 description 1
- 229940055619 selenocysteine Drugs 0.000 description 1
- 235000016491 selenocysteine Nutrition 0.000 description 1
- 229960002718 selenomethionine Drugs 0.000 description 1
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- 230000005760 tumorsuppression Effects 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
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- 239000002699 waste material Substances 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01G—HORTICULTURE; CULTIVATION OF VEGETABLES, FLOWERS, RICE, FRUIT, VINES, HOPS OR SEAWEED; FORESTRY; WATERING
- A01G22/00—Cultivation of specific crops or plants not otherwise provided for
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L19/00—Products from fruits or vegetables; Preparation or treatment thereof
- A23L19/09—Mashed or comminuted products, e.g. pulp, purée, sauce, or products made therefrom, e.g. snacks
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L23/00—Soups; Sauces; Preparation or treatment thereof
- A23L23/10—Soup concentrates, e.g. powders or cakes
-
- C—CHEMISTRY; METALLURGY
- C05—FERTILISERS; MANUFACTURE THEREOF
- C05D—INORGANIC FERTILISERS NOT COVERED BY SUBCLASSES C05B, C05C; FERTILISERS PRODUCING CARBON DIOXIDE
- C05D9/00—Other inorganic fertilisers
- C05D9/02—Other inorganic fertilisers containing trace elements
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12G—WINE; PREPARATION THEREOF; ALCOHOLIC BEVERAGES; PREPARATION OF ALCOHOLIC BEVERAGES NOT PROVIDED FOR IN SUBCLASSES C12C OR C12H
- C12G3/00—Preparation of other alcoholic beverages
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- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Polymers & Plastics (AREA)
- Nutrition Science (AREA)
- Food Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Environmental Sciences (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Botany (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Inorganic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
본 발명은 뽕나무에 게르마늄, 셀레늄-함유 물질을 비료로 공급, 재배하여 게르마늄과 셀레늄이 함유된 뽕잎을 수확하고 열매인 오디의 효소를 제조하는 방법으로,The present invention is a method of producing mulberry leaves germanium and selenium-containing mulberry leaves by supplying and cultivating germanium, selenium-containing material to the mulberry, and producing the enzyme of the fruit of the mulberry,
본 발명에 따라 재배되는 게르마늄, 셀레늄-함유 뽕잎과 오디는 인체에 독성이 없고 흡수율이 높은 유기 셀레늄과 게르마늄이 다량 함유되어 있어 과일이나 식품으로서 섭취하여 셀레늄 성분의 알려진 기능인 항산화력, 심장과 폐기능 향상, 노폐물질 분해, 간경화증 예방, 면역기능 향상, 성적기능 향상, 근이 영양증 치료, 항암 예방에 기여할 수 있다.Germanium, selenium-containing mulberry leaves and cultivated according to the present invention is not toxic to the human body and contains a large amount of organic selenium and germanium having high absorption rate, which is ingested as a fruit or food, antioxidant power, heart and lung function of the known function of selenium component Enhancement, decomposition of waste substances, prevention of cirrhosis of the liver, improvement of immune function, improvement of sexual function, muscle nourishment treatment, anticancer prevention.
최근에는 원하는 영양소나 원소 또는 물질을 기존의 농축산물에 함유시켜 영양학적 부가가치를 높이려는 노력이 계속되고 있다. 그 대표적인 예로, 오메가 3 지방산이 다량 함유된 계란 및 인삼 등을 사료에 이용한 인삼란 등이 이미 시판되고 있다. 또한 육류 및 유류 등의 축산물에서도 특정의 유용성분을 축적시키려는 시도가 있다.Recently, efforts have been made to increase nutritional added value by adding desired nutrients, elements or substances to existing agricultural products. As a representative example, ginseng eggs using eggs and ginseng containing a large amount of omega-3 fatty acids in feed are already commercially available. There are also attempts to accumulate certain useful components in livestock products such as meat and oil.
최근 고도의 산업화로 공장폐수 및 공기오염 등에 의한 환경오염은 날로 심각해지고 있으며, 많은 근로자들은 작업환경에서 발생하는 중금속에 의한 중독으로 시달리고 있고, 또한 이러한 중독 위험에 지속적으로 노출된 상태에 있다.Recently, due to the high industrialization, environmental pollution caused by factory wastewater and air pollution is getting serious day by day, and many workers are suffering from poisoning by heavy metals generated in the working environment, and they are continuously exposed to such poisoning risks.
이러한 환경오염으로 인한 중금속 중독의 해독을 위한 하나의 방법으로서, 해독성분이 함유된 식품을 지속적으로 섭취하여 만성적으로 노출되는 환경오염으로부터 인체를 보호하는 방법이 있다.As a method for the detoxification of heavy metal poisoning due to such environmental pollution, there is a method of protecting the human body from chronic environmental exposure by continuously ingesting food containing the detoxification component.
게르마늄은 주기율표 4B족에 속하는 탄소족원소의 하나. 원소기호 Ge, 원자번호 32, 원자량 72.59%로 먹는 산소로 알려져 있다.Germanium is one of the carbon group elements belonging to group 4B of the periodic table. It is known as the elemental symbol Ge, atomic number 32, and oxygen for which the atomic weight is 72.59%.
순도가 높은 유기게르마늄은 복용 후 인체 내에서 각종 임무를 마친 후 약 20-30시간 안에 인체 내에 있는 암 세포, 독소, 오염물질, 중금속 등을 붙들고 축적되는 것 없이 소변을 통해 인체에서 완전히 빠져나가므로 전혀 독성이 남지 않아 매우 안전하다.High-purity organic germanium completely escapes from the human body through urine without holding and accumulating cancer cells, toxins, contaminants, and heavy metals in the human body within about 20-30 hours after taking various tasks in the human body after taking them. It is very safe because there is no toxicity at all.
Source: Asai Germanium Research Institute, Tokyo, Japan.Source: Asai Germanium Research Institute, Tokyo, Japan.
동물실험 28일과 6개월 1mg/kg/Day 투여하며 정밀 관찰 결과 6개월 마지막에 수놈에게서 아주 약간의 무게가 줄어든 것 외에는 어떤 특별한 독성이나 중독 현상이 없었으며 동작이나 행동에도 이상이 발견되지 않았다. 뿐만 아니라 게르마늄은 복용하는 대로 소변을 따라 배출되기 때문에 6개월 후의 검사에서 어느 기관에서도 축적이나 중독 증상이 없었다.On the 28th and 6th month of the animal experiment, 1mg / kg / Day was administered and there was no specific toxicity or poisoning phenomenon except for the slight weight loss of the male at the end of the 6th month. In addition, because germanium is excreted in the urine as it is taken, there were no symptoms of accumulation or poisoning in any organ after 6 months of testing.
Source: Journal de Toxicologie Clinique et Experimental Dec. 11, 1991(7-8) 421-36-Source: Journal de Toxicologie Clinique et Experimental Dec. 11, 1991 (7-8) 421-36-
유기게르마늄(Ge-132)은 세포들의 부상(상해)을 예방Organo germanium (Ge-132) prevents injury to cells
게르마늄(Ge-132)의 상해(부상)를 입은 세포들에 대한 효과의 동물실험 연구에서 게르마늄(Ge-132)을 투여한 동물들의 세포들의 부상에 대한 예방과 스스로 치료되어지는 것을 발견하였다. 이 모든 효과들은 게르마늄(Ge-132)의 역할과 관련이 있다. 이러한 결과들은 게르마늄(Ge-132)이 세포들의 원활한 신진대사를 촉진하여 그것이 부상으로부터 보호되고 있는 것으로 보여진다.Animal studies of the effects of germanium (Ge-132) on injured (injury) cells have found that the treatment of the cells of germanium (Ge-132) -treated animals prevents and injuries themselves. All these effects are related to the role of germanium (Ge-132). These results show that germanium (Ge-132) promotes smooth metabolism of cells, which is protected from injury.
Source: Yao Hsueh Hsueh Pao Acta Pharmaceutica Sinica, 1992, 27(7): 481-5Source: Yao Hsueh Hsueh Pao Acta Pharmaceutica Sinica, 1992, 27 (7): 481-5
만성 피로를 완화시켜 주는 개체로써의 게르마늄(Ge-132)Germanium as an Individual to Alleviate Chronic Fatigue (Ge-132)
게르마늄이 바이러스성의 만성피로 증후군(Chronic Epstein-Barr Virus Syndrome)의 증상을 약화시키고 완화시켜 준다는 사실이 발견되었다. 수백만의 미국인은 물론 세계 각국의 많은 사람들이 이 바이러스성의 만성피로 증후군(Chronic Epstein-Barr Virus Syndrome)으로 고통 받고 있다.Germanium has been found to attenuate and alleviate the symptoms of the Chronic Epstein-Barr Virus Syndrome. Millions of Americans, as well as many people around the world, suffer from this chronic Epstein-Barr Virus Syndrome.
Source: Use of Organic Germanium in Chronic Epstein-Barr Virus Syndrome,' Journal of Orthomolecular Medicine, 1989Source: Use of Organic Germanium in Chronic Epstein-Barr Virus Syndrome, 'Journal of Orthomolecular Medicine, 1989
게르마늄은 백내장의 진전을 늦춘다, Ge-132는 백내장의 진전을 늦췄으며, 백내장의 예방과 치료에도 좋은 효과를 보였다.Germanium slows the development of cataracts, Ge-132 slows the development of cataracts, and has been shown to be effective in the prevention and treatment of cataracts.
Source: Department of Biological Sciences, Oakland University, Rochester, MI, Experimental Eye Research, August 1995.'Source: Department of Biological Sciences, Oakland University, Rochester, MI, Experimental Eye Research, August 1995. '
돌연변이성 인자의 억제제로써의 게르마늄Germanium as an inhibitor of mutagenic factor
많은 연구들이나 논문 등에서는 평상시 여러 가지 필수 영양소들을 골고루섭취하기를 권한다. 특히 산화방지제, 비타민, 셀레늄 같은 영양소들은 잠재적이며 확실한 발암물질의 억제제이기 때문이다. 더 나아가서, 일정 양의 게르마늄을 꾸준히 복용하면 돌연변이성의 인자들이 억제되는 현상을 보이고 있다.Many studies and papers recommend that you take your daily essential nutrients evenly. In particular, nutrients such as antioxidants, vitamins and selenium are potential and definitive carcinogen inhibitors. Furthermore, constant doses of germanium have been shown to inhibit mutagenic factors.
Source: Department of Oral Biology, Indiana University School of Dentistry, Indianapolis 46202. Mutation Research 1995 Aug., 335(1): 21-6Source: Department of Oral Biology, Indiana University School of Dentistry, Indianapolis 46202.Mutation Research 1995 Aug., 335 (1): 21-6
수술 후의 회복과 면역력을 높이는 게르마늄Germanium improves postoperative recovery and immunity
게르마늄은 수술 후의 탐식 세포들, 백혈구의 염색질들, 혈액 주위의 림프구들, 또 이들의 콘트롤 그룹 등의 거부 반응에 대한 면역학적인 반응의 증대와 인터페론 유도체로써의 효과가 입증되었다. 게르마늄의 그런 효과들은 수술 후 오랜 기간 지속되었으며, 이러한 결과들은 수술 후의 면역 거부 반응에 대한 동물들의 실험에서 게르마늄이 수술에 따른 면역 거부 반응의 여러 임상적인 증상들에 대하여 예방과 치료제로써의 효과가 있는 것으로 보여진다.Germanium has been shown to be effective as an interferon derivative and to enhance immunological response to rejection of post-operative phagocytes, leukocyte chromatin, lymphocytes around blood, and their control groups. Such effects of germanium persisted for a long time after surgery, and these results suggest that germanium is effective as a prophylactic and therapeutic agent for several clinical symptoms of postoperative immune rejection in animals. It is shown.
Source: Journal of Veterinary Medical Science, 1993 Oct., 55(5): 795-9.Source: Journal of Veterinary Medical Science, 1993 Oct., 55 (5): 795-9.
암, 악성종양에 대한 게르마늄의 효과Effect of Germanium on Cancer and Malignant Tumors
16-19세기의 많은 연구 논문, 임상보고들에 의하면 금속, 금속성분의 화합물들이 암, 백혈병 등의 치료에 유용하다는 언급들을 하고 있다. 그러나 불행스럽게도 무기화합물, 금속화합물 등에 의해서 악성종양, 암 등이 정복될 수 있다는 사실, 즉 그런 연구들이 1960년까지는 사람들에게 잊혀지고 있었다. 게르마늄을 포함한 많은 금속화합물들이 동물들의 실험과 사람의 임상실험에서 항 암과 악성종양 제거제로써의 커다란 효과를 보여주고 있다는 사실을...... Source: EuropeanJournal of Clinical Pharmacology, 1994, 47(1):1-16Many research papers and clinical reports from the 16th and 19th centuries have mentioned that metals and metal compounds are useful in the treatment of cancer and leukemia. Unfortunately, the fact that malignant tumors, cancers, etc. can be conquered by inorganic and metal compounds, that is, such studies were forgotten by people until 1960. The fact that many metal compounds, including germanium, have shown great effects as anticancer and malignant tumor removers in animal and human clinical trials. Source: European Journal of Clinical Pharmacology, 1994, 47 (1 ): 1-16
동물 실험에서 유기 게르마늄은 혈압을 낮추는 작용과 많은 관계가 있으며, 이러한 유기 게르마늄의 혈압 강하 작용에 대한 연구 결과들은 1979년 일본 암 협회의 도꾜에서 있었던 제 38차 연례회의의 회의록 112페이지에 나와 있다. Source: The Clinical Report (Kiso to Rinsho, in Japanese) 7(1978):719In animal experiments, organic germanium has a lot to do with blood pressure-lowering effects, and the results of these studies on the blood pressure-lowering effects of organic germanium are found in page 112 of the 38th annual meeting of the 38th Annual Meeting in Tokyo, Japan. Source: The Clinical Report (Kiso to Rinsho, in Japanese) 7 (1978): 719
유기 게르마늄은 면역 반응 체계를 완전히 상실한 노쇠한 쥐들에게서 면역체계가 원 상태로 복구되는 것이 고찰되었다.Organic germanium has been considered to restore the immune system to its original state in older mice that have lost their immune response.
Source: International Archives of Allergy 63(1980): 338-339Source: International Archives of Allergy 63 (1980): 338-339
게르마늄은 Salmonella 구균에서 돌연변이유발에 대한 억제의 유도 작용으로써의 강력한 효능이 보여졌으며, 또한 박테리아에 대한 돌연변이유발 억제효과들이 주목되어 졌다. Source: Mutation Research 125 (1984): 145-151Germanium has been shown to be a potent potent inhibitor of mutagenesis in Salmonella cocci, and its effects on bacteria have been noted. Source: Mutation Research 125 (1984): 145-151
유기 게르마늄은 골다공증 환자들에게 뼈의 골절 방지는 물론 골다공증을 감소시키는 것으로 나타났다.Organic germanium has been shown to reduce osteoporosis as well as bone fracture in osteoporosis patients.
Source: Asai Germanium Research Institute, Tokyo, Japan, 1984.Source: Asai Germanium Research Institute, Tokyo, Japan, 1984.
게르마늄의 경구 투여는 인터페론 유도물질이 인체 내에서 조정되어 지는 긍정적인 효과들이 있었다.Oral administration of germanium has the positive effect that the interferon inducer is regulated in the body.
Source: Microbiology and Immunology 29, 1985:65-74.Source: Microbiology and Immunology 29, 1985: 65-74.
게르마늄 산화물(유기 게르마늄)은 인체 내에서 아주 중요한 인터페론 유도체로써 작용하는 것으로 나타났다. Source: Proceedings of the Japan Cancer Association Ⅱ, Annual Meeting, 1979, Page193.Germanium oxide (organic germanium) has been shown to act as an important interferon derivative in the human body. Source: Proceedings of the Japan Cancer Association II, Annual Meeting, 1979, Page 193.
유기 게르마늄은 종양, 악성 종양을 억제시킨다는 사실이 증명되었다.Organic germanium has been shown to inhibit tumors, malignant tumors.
Source: Cancer and Chemotherapy 6, in Japanese, (1968): 79-83.Source: Cancer and Chemotherapy 6, in Japanese, (1968): 79-83.
유기 게르마늄을 경구 투여한 경우는 생명이 현저하게 연장된다는 사실이 관찰되었다. Source: Gan To Kagaku Ryoho 12, December 1985:2345-51.Oral administration of organic germanium has been observed to significantly prolong life. Source: Gan To Kagaku Ryoho 12, December 1985: 2345-51.
유기 게르마늄이 강력한 종양, 악성 종양 억제제라는 것은, 유기 게르마늄의 인터페론 유도체로써의 작용과 관련이 있는 것으로 나타났다.The fact that organic germanium is a potent tumor and malignant tumor suppressor has been shown to be related to the function of organic germanium as an interferon derivative.
Source: Tohoku Journal of Experimental Medicine 146, May 1985:97Source: Tohoku Journal of Experimental Medicine 146, May 1985: 97
종양 억제에 대한 동물 실험 결과에서, 유기 게르마늄을 투여한 동물들에게서는 종양의 자라는 것이 멈췄으며 머지 않아 종양이 줄어들었다.In animal experiments on tumor suppression, tumors stopped growing in animals administered with organic germanium and the tumors soon contracted.
Source: Anticancer Research 6, March-April 1986:177-82.Source: Anticancer Research 6, March-April 1986: 177-82.
유기 게르마늄의 치료효과에 대한 동물 실험에서 종양을 확실하게 자라지 못하도록 하는 효과를 보였다. 이런 현상들은 인체 내의 탐식세포의 활발한 활동의 결과가 효과로 나타난 것으로 보여진다. (탐식 세포도 하나의 면역시스템이며, 그들은 적을 공격한다)Animal experiments on the therapeutic effects of organic germanium have been shown to prevent tumor growth. These phenomena appear to be the result of the active activity of the phagocytic cells in the body. (The phagocytic cells are also an immune system, they attack the enemy)
Source: Gan To Kagaku Ryoho 12 November 1985:2122-8.Source: Gan To Kagaku Ryoho 12 November 1985: 2122-8.
유기 게르마늄이 종양억제제로써 항암제 키모떼라피(Chemotherapy)와 함께 사용되면 어떤 결과가 나올까에 대해서 연구하게 되었다. 결과들에 의하면 종양의 성장은 정지했으며, 종양의 전이억제 효과가 있었고, 생명의 생존기간이 연장되었고, 그리고 키모떼라피(Chemotherapy)의 부작용을 줄여 주었고 아울러 항암제 사용으로 줄어든 몸무게가 회복되었다.We have studied the results of organic germanium when used with chemotherapy, an anticancer drug, as a tumor suppressor. The results showed that tumor growth stopped, tumor metastasis was inhibited, life span was prolonged, the side effects of chemotherapy were reduced, and the weight lost to chemotherapy was restored.
Source: Gan To Kagaku Ryoho 13, Aug. 1986:2588-93.Source: Gan To Kagaku Ryoho 13, Aug. 1986: 2588-93.
암 종양, 백혈병세포를 접종시킨 동물들에게 유기 게르마늄을 복용하여 치료하는 실험을 하였다. 이 연구에서 유기 게르마늄은 암 세포를 직접 공격하는 것보다는 신체의 방어기능의 향상을 통한 효과가 있는 것으로 증명되었다. 즉 탐식 세포와 T-세포들을 포함 한 면역체계의 향상을 통한 작용으로 보인다. Source: Anticancer Research 5, Sep.-Oct. 1985:479-83Animals inoculated with cancer tumors and leukemia cells were treated with organic germanium. In this study, organic germanium has been shown to be effective in improving the body's defenses rather than directly attacking cancer cells. In other words, the immune system including phagocytic cells and T-cells seems to work. Source: Anticancer Research 5, Sep.-Oct. 1985: 479-83
혈압의 변화에 대항 동물실험에서, 정상적인 혈압의 동물들에게 게르마늄을 투여한 후의 관찰에서 정상적인 혈압 그대로 아무런 변화가 없었다. 그러나 혈압이 높은 동물들에게 투여한 후에는 게르마늄을 투여한지 7-10일에 놀랍게도 혈압이 정상 치로 돌아왔다. 이 효과는 게르마늄의 투여를 중단한 후로도 상당히 오랫동안 지속되었다.In animal experiments against changes in blood pressure, normal blood pressure was not changed as observed after germanium administration to animals with normal blood pressure. However, after the administration of animals with high blood pressure, the blood pressure was surprisingly returned to normal 7-10 days after Germanium administration. This effect persisted for quite some time after stopping the administration of germanium.
Source: Japan Experimental Research Institute, Tokyo, Japan.Source: Japan Experimental Research Institute, Tokyo, Japan.
유기 게르마늄은 경구투여와 주사에서 똑같이 모르핀과 같은 강력한 진통효과를 보여주었다. 게르마늄을 복용 또는 투여하면 인체 내에서 엔돌핀의 생산을 늘리고, 인체의 각 감각기관들이 진통작용을 늘리는 것으로 나타났다.Organic germanium has shown the same strong analgesic effect as morphine in oral and injection. Taking or administering germanium has been shown to increase the production of endorphins in the body and to increase the analgesic effects of each organ of the body.
Source: Journal of Pharmacological Dynamics 6(1983):814-820.Source: Journal of Pharmacological Dynamics 6 (1983): 814-820.
순도가 높은 유기게르마늄은 복용 후 인체 내에서 각종 임무를 마친 후 약 20-30시간 안에 인체 내에 있는 암 세포, 독소, 오염물질, 중금속 등을 붙들고 축적되는 것 없이 소변을 통해 인체에서 완전히 빠져나가므로 전혀 독성이 남지 않아 매우 안전하다.High-purity organic germanium completely escapes from the human body through urine without holding and accumulating cancer cells, toxins, contaminants, and heavy metals in the human body within about 20-30 hours after taking various tasks in the human body after taking them. It is very safe because there is no toxicity at all.
Source: Asai Germanium Research Institute, Tokyo, Japan.Source: Asai Germanium Research Institute, Tokyo, Japan.
기적의 원소, 푸른 빛의 마법사.... 미국 등 선진국에서는 셀레늄(Selenium)을 이렇게 부른다. 노화 방지-암 예방-면역기능 활성화 등에 효과가 있다고 해서다.Elements of miracles, wizards of blue light .. In developed countries such as the United States, selenium is called. It is said to be effective for anti-aging, cancer prevention, and immune function activation.
원소기호가 Se인 초기에 독성이 있는 원소여서 적당한 사용처를 찾지 못해 오랫동안 철저하게 잊혀진 원소로 존재했다. 독성에 관한 가장 오래된 기록은 13세기 마르코 폴로의 [동방견문록]에서 찾아볼 수 있으며 1860년에는 사우스다코타 지역에 주재하던 군대의 군의관이 말에서 셀레늄 중독 증상을 보고한 기록이 있다. 셀레늄을 과잉섭취하면서 털과 발굽이 빠지는 치명적인 증상이 나타난 것이다. 하지만 1960년대 이후 결핍과 관련된 연구가 활발해지면서 관심을 끌기 시작했다. 이런 과정 중 1973년에는 셀레늄이 동물체내에서 항산화작용(일종의 노화 방지)을 하는 효소인 글루타티온 퍼옥시다제의 필수 구성 성분임이 밝혀졌다. 이후 1978년에는 세계보건기구(WHO)가 셀레늄을 필수 영양소로 인정하고 50~200μg을 1일 권장량으로 정했다. 선진국에서 불고 있는 셀레늄 열풍이 국내에도 상륙할 조짐을 보이고 있다. 젓갈-닭고기 등에 셀레늄 성분을 강화한 제품이 속속 나오고 있고, 제약회사에서도 종합비타민제에 셀레늄 첨가를 서두르고 있다. 최근에는 사스(SARS-중증급성호흡기증후군)의 원인으로 셀레늄 결핍이 지목되면서 전세계적으로 셀레늄에 대한 관심이 부쩍 높아졌다.In the early period when the element symbol was Se, it was a toxic element, so it existed as a long forgotten element because it could not find a suitable use. The oldest record of toxicity can be found in the 13th-century Marco Polo's Eastern Gate, and in 1860, a military surgeon in South Dakota reported horses showing selenium poisoning. Excessive intake of selenium caused fatal symptoms of hair and hoof fall out. However, since the 1960s, research on deficiency has become active and has attracted interest. In 1973, selenium was found to be an essential component of glutathione peroxidase, an enzyme that acts as an antioxidant in animals. In 1978, the World Health Organization (WHO) recognized selenium as an essential nutrient and set 50-200 μg as the recommended daily dose. Selenium fever blowing in developed countries is showing signs of landing in Korea. Products that have enhanced selenium content in salted fish and chicken are being introduced one after another, and pharmaceutical companies are rushing to add selenium to multivitamins. In recent years, selenium deficiency has been identified as a cause of SARS, and interest in selenium has increased significantly around the world.
셀레늄 섭취 권장량은 지역마다, 그리고 여러 환경(흡연·임신·질병 유무 등)에 따라 다르다. 예컨대, 미국영양학회에서의 권장량은 55~70 μg이며, WHO 권장량은 50~200μg이다. 영국건강학회에서는 최적 의 건강 상태를 위해 섭취량으로 500μg을 권장하고 있다. 암환자를 치료하기 위해 투여하는 양은 1,000∼2,000μg이다. 아직 국내에서는 최적 건강을 위한 섭취량에 대한 연구 결과가 나와 있지 않다.Recommended selenium intake varies from region to region and in different environments (smoking, pregnancy, illness, etc.). For example, the recommended amount for the American Nutrition Society is 55-70 μg, and the WHO dose is 50-200 μg. The British Institute of Health recommends 500 μg intake for optimal health. The amount administered to treat cancer patients is 1,000-2,000 μg. There are no studies on intake for optimal health in Korea.
우리나라 사람은 하루에 약 40㎍의 셀레늄을 주로 곡류로부터 얻고 있는 것으로 추정되고 있다. 이는 WHO의 1일 섭취 권장량에 못 미치는 수준이다. 즉 추가 적인 섭취가 필요하다.It is estimated that Koreans obtain about 40 ㎍ of selenium from grains per day. This is below the WHO's recommended daily intake. That is, additional intake is required.
이에 본 발명자이 출원한 발명특허 10-2003-0089903, 10-2004-0023578의 출원번호에 제시된 셀레늄과 게르마늄을 이온화시키는 방법으로 뽕나무와 오디에 셀레늄과 게르마늄을 전이시키는데 성공하였으며 발명을 완성하게 되었다.Therefore, the method of ionizing the selenium and germanium shown in the patent application number 10-2003-0089903 and 10-2004-0023578 of the present inventors has succeeded in transferring mulberry and odylian selenium and germanium and completed the invention.
따라서, 본 발명의 목적은 체내 흡수율이 높으며, 인체 이용성이 좋은 안전한 게르마늄, 셀레늄이 함유된 뽕잎과 오디를 제공하는데 있다.Accordingly, an object of the present invention is to provide a safe germanium, selenium-containing mulberry leaves and mulberry with a high absorption rate in the body.
또 다른 목적은 게르마늄과 셀레늄이 함께 함유된 뽕잎과 열매인 오디를 제공하는데 있다.Another object is to provide mulberry leaves and fruit, which are both germanium and selenium together.
본 발명의 목적을 달성하기 위한 방법으로 셀레늄을 함유하는 유기 화합물인 셀레노시스테인 및 셀레노메치오닌 등으로 전환시키기 위해 무기 셀레늄을 효모균체 생산시에 첨가하여 발효시 효모균체 내에서 유기 셀레늄으로 전환시킨 셀레늄-효모 복합체 또는 상기 셀레늄-효모 복합체와 셀레늄을 함유하는 모든 화합물과 게르마늄은 무기 게르마늄 이외에, 게르마늄을 함유하는 모든 화합물, 게르마늄-효모 복합체, Ge132, 킬레이팅된 유기 게르마늄등을 사용할 수 있지만, 본 발명의 목적을 달성하기 위한 발명으로 바람직하게 출원번호:10-2003-0089903, 10-2004-0023578에 설명된 방법으로 셀레늄과 게르마늄을 이온화 시켜 뽕나무에 비료로 사용하여 인체에 흡수율이 높으며 인체 이용성이 좋은 안전한 유기게르마늄과 셀레늄을 함유하는 뽕잎과 오디를 생산하는데 성공하여 본 발명을 완성하였다.In order to achieve the object of the present invention, in order to convert into selenium-containing organic compounds such as selenocysteine and selenomethionine, inorganic selenium was added during the production of yeast cells and converted into organic selenium in the yeast cells during fermentation. The selenium-yeast complex or all compounds and germanium containing selenium-yeast complex and selenium may use all compounds containing germanium, germanium- yeast complex, Ge132, chelated organic germanium, etc., in addition to inorganic germanium, but As an invention for achieving the object of the invention it is preferred to ionize selenium and germanium by the method described in Application No.:10-2003-0089903, 10-2004-0023578 and use it as a fertilizer to mulberry, which has high absorption rate to human body and human availability Produces mulberry leaves and audi containing good safe organic germanium and selenium We have completed the present invention to success.
본 발명을 하기 위해 시험예에 의해 설명하지만, 이들에 의해 본 발명의 범위가 제한되는 것은 아니다.Although a test example demonstrates for this invention, the scope of the present invention is not restrict | limited by these.
본 발명에 대해 구체적으로 설명한다. 그러나 농업의 특성상 여러가지 환경 즉 습도, 토양, 광량, 온도, 등에 따라 실험의 결과가 다르게 나올 수 도 있으나 본 발명자들이 실험한 조건대로 설명한다.This invention is demonstrated concretely. However, due to the characteristics of agriculture, the results of the experiment may be different depending on various environments, that is, humidity, soil, light quantity, temperature, etc. The present invention will be described according to the conditions tested.
시험예 1Test Example 1
출원번호:10-2003-0089903, 10-2004-0023578에 설명된 방법으로 무기 셀레늄을 이온화 시켜 농도를 조정한 후 싹이나기 시작하는 뽕나무에, 5일 간격으로 관주 1ppm의 농도로 3회, 옆면시비 5ppm의 농도로 뽕나무 1그루에 1터씩 5회를 처리하였다. 처리구에서 수확한 뽕잎과 오디를 수확하여 함유된 셀레늄의 함량을 조사하였다. 뽕잎은 0.465mg/kg 오디는 0.075mg/kg 유기화된 셀레늄이 함유된 것을 알수 있었다.On the mulberry tree which begins to sprout after adjusting the concentration by ionizing inorganic selenium by the method described in Application No.:10-2003-0089903, 10-2004-0023578, three times at a concentration of 1 ppm of irrigation at 5 days intervals. The fertilizer was treated five times, one to one mulberry tree, at a concentration of 5 ppm. The mulberry leaves and the mulberry harvested from the treatment were harvested and the content of selenium was examined. Mulberry leaf 0.465mg / kg Audi was found to contain 0.075mg / kg organic selenium.
시험예 2Test Example 2
무기 게르마늄 GeO2를 이온화 시켜 농도를 조정한 후 싹이 나기 시작하는 뽕나무에 관주 1ppm의 농도로 3회, 옆면시비 3ppm의 농도로 뽕나무 1그루에 1터씩 5회를 처리하였다. 처리구에서 수확한 뽕잎에서 0.2mg/kg 오디는 0.050mg/kg 이상의 유기화된 게르마늄이 함유된 것을 알 수 있었다.After adjusting the concentration by ionizing the inorganic germanium GeO2, the mulberry tree, which started to sprout, was treated three times at a concentration of 1 ppm of irrigation, and five times at one concentration of one mulberry tree at a concentration of 3 ppm of lateral fertilization. In mulberry leaves harvested from the treatment was found that 0.2mg / kg mulberry contained more than 0.050mg / kg of the organic germanium.
시험예 3Test Example 3
무기 셀레늄과 게르마늄을 이온화 시켜 농도를 조정한 후 싹이나기 시작하는 뽕나무에, 5일 간격으로 셀레늄 5ppm)과 게르마늄은 3ppm)의 농도로 옆면시비 처리하였다.After adjusting the concentration by ionizing the inorganic selenium and germanium, the mulberry starting to sprout, was treated with side fertilization at a concentration of 5 ppm selenium and 3 ppm germanium at intervals of 5 days.
1ppm의 농도로 셀레늄과 게르마늄을 교반한 후 관주 처리하였고, 잎과 오디를 수확하여 함유된 셀레늄과 게르마늄의 함량을 조사하였다. 함유된 셀레늄의 함량은 (0.45mg/kg) 오디는 (0.07mg/kg) 게르마늄의 함량은 (0.25mg/kg) 오디는 (0.060mg/kg)의 유기화된 셀레늄과 게르마늄이 함유된 것을 알 수 있었다.After stirring the selenium and germanium at a concentration of 1ppm and irrigation treatment, the leaves and the Audi was harvested and the contents of selenium and germanium were investigated. The content of selenium is (0.45mg / kg) and that of Audi (0.07mg / kg) and that of germanium is (0.25mg / kg) and that of (0.060mg / kg) is that of organicated selenium and germanium there was.
본 발명에 따라 제조되는 셀레늄-함유 뽕나무는 인체에 독성이 없고 흡수율이 높은 유기 셀레늄이 다량 함유되어 있음을 알 수 있다.It can be seen that the selenium-containing mulberry prepared according to the present invention contains a large amount of organic selenium which is not toxic to the human body and has a high absorption rate.
또한 본 발명으로 항암 항 산화효과가 있는 셀레늄이 함유된 뽕나무를 생산하여 과일과 과즙, 효소를 섭취함으로서 자연스럽게 치료 및 예방효과가 있는 천연 셀레늄을 섭취할 수 있는 효과가 있다.In addition, by producing a mulberry tree containing selenium having an anti-cancer antioxidant effect by the present invention, by ingesting fruit, fruit juice, enzymes, there is an effect of naturally ingesting natural selenium having a therapeutic and preventive effect.
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Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
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CN102515910A (en) * | 2011-11-17 | 2012-06-27 | 张瑶 | Functional bacterial manure nutrient solution for plants, application and preparation method thereof |
CN104429487A (en) * | 2014-11-14 | 2015-03-25 | 陶玲云 | Method for planting mulberry trees |
CN106613312A (en) * | 2016-09-30 | 2017-05-10 | 桂林淮安天然保健品开发有限公司 | Method for harvesting selenium-rich ganoderma-lucidum-karst spore powder |
CN111011116A (en) * | 2019-12-18 | 2020-04-17 | 天津长芦汉沽盐场有限责任公司 | Efficient selenium enrichment method for sea asparagus |
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Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
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CN102515910A (en) * | 2011-11-17 | 2012-06-27 | 张瑶 | Functional bacterial manure nutrient solution for plants, application and preparation method thereof |
CN104429487A (en) * | 2014-11-14 | 2015-03-25 | 陶玲云 | Method for planting mulberry trees |
CN106613312A (en) * | 2016-09-30 | 2017-05-10 | 桂林淮安天然保健品开发有限公司 | Method for harvesting selenium-rich ganoderma-lucidum-karst spore powder |
CN111011116A (en) * | 2019-12-18 | 2020-04-17 | 天津长芦汉沽盐场有限责任公司 | Efficient selenium enrichment method for sea asparagus |
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