KR20040006092A - Dermis-accelerant Including the Fine Pure Pearl Powder - Google Patents
Dermis-accelerant Including the Fine Pure Pearl Powder Download PDFInfo
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- KR20040006092A KR20040006092A KR1020020039614A KR20020039614A KR20040006092A KR 20040006092 A KR20040006092 A KR 20040006092A KR 1020020039614 A KR1020020039614 A KR 1020020039614A KR 20020039614 A KR20020039614 A KR 20020039614A KR 20040006092 A KR20040006092 A KR 20040006092A
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- pearl powder
- skin
- powder
- dermis
- pearl
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- 239000000843 powder Substances 0.000 claims abstract description 49
- 239000004480 active ingredient Substances 0.000 claims abstract description 4
- 239000002775 capsule Substances 0.000 claims abstract description 4
- 239000008187 granular material Substances 0.000 claims abstract description 4
- 239000003795 chemical substances by application Substances 0.000 claims description 9
- 210000003169 central nervous system Anatomy 0.000 claims description 8
- 230000001737 promoting effect Effects 0.000 claims description 8
- 238000000034 method Methods 0.000 claims description 4
- 239000007788 liquid Substances 0.000 claims description 3
- 239000006072 paste Substances 0.000 claims description 3
- 239000003826 tablet Substances 0.000 claims description 3
- 206010013786 Dry skin Diseases 0.000 abstract description 6
- 230000037303 wrinkles Effects 0.000 abstract description 6
- 239000011049 pearl Substances 0.000 description 38
- 210000003491 skin Anatomy 0.000 description 23
- 241000700159 Rattus Species 0.000 description 7
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 5
- 241001465754 Metazoa Species 0.000 description 5
- 230000000202 analgesic effect Effects 0.000 description 5
- 229920002674 hyaluronan Polymers 0.000 description 5
- 229960003160 hyaluronic acid Drugs 0.000 description 5
- SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 description 3
- 229920002101 Chitin Polymers 0.000 description 3
- 229920001287 Chondroitin sulfate Polymers 0.000 description 3
- 241000238557 Decapoda Species 0.000 description 3
- 229920002683 Glycosaminoglycan Polymers 0.000 description 3
- 229940059329 chondroitin sulfate Drugs 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 102000008186 Collagen Human genes 0.000 description 2
- 108010035532 Collagen Proteins 0.000 description 2
- 206010012735 Diarrhoea Diseases 0.000 description 2
- 210000001015 abdomen Anatomy 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 230000036592 analgesia Effects 0.000 description 2
- 230000003796 beauty Effects 0.000 description 2
- 229920001436 collagen Polymers 0.000 description 2
- 229960005188 collagen Drugs 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 230000002500 effect on skin Effects 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 230000037406 food intake Effects 0.000 description 2
- 150000004676 glycans Chemical class 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 235000013336 milk Nutrition 0.000 description 2
- 239000008267 milk Substances 0.000 description 2
- 210000004080 milk Anatomy 0.000 description 2
- 229920001282 polysaccharide Polymers 0.000 description 2
- 239000005017 polysaccharide Substances 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 229930186217 Glycolipid Natural products 0.000 description 1
- 102000003886 Glycoproteins Human genes 0.000 description 1
- 108090000288 Glycoproteins Proteins 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical compound [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 206010003246 arthritis Diseases 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000004040 coloring Methods 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 230000034994 death Effects 0.000 description 1
- 231100000517 death Toxicity 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 150000002337 glycosamines Chemical class 0.000 description 1
- 239000011121 hardwood Substances 0.000 description 1
- 235000013402 health food Nutrition 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 230000003301 hydrolyzing effect Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000007800 oxidant agent Substances 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- 230000036407 pain Effects 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 239000004014 plasticizer Substances 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 235000015170 shellfish Nutrition 0.000 description 1
- 210000004927 skin cell Anatomy 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 230000002087 whitening effect Effects 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/38—Other non-alcoholic beverages
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/52—Adding ingredients
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/16—Inorganic salts, minerals or trace elements
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2200/00—Function of food ingredients
- A23V2200/30—Foods, ingredients or supplements having a functional effect on health
- A23V2200/318—Foods, ingredients or supplements having a functional effect on health having an effect on skin health and hair or coat
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2250/00—Food ingredients
- A23V2250/15—Inorganic Compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/92—Oral administration
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Food Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Nutrition Science (AREA)
- Polymers & Plastics (AREA)
- Dermatology (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Inorganic Chemistry (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Mycology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Description
본 발명은 진주가루를 섭취함으로써 이 진주가루가 중추신경계통에 작용하여 피부의 촉촉함과 팽팽함을 향상시키고, 살갗 거칠어짐이나 잔주름 등의 예방·개선을 촉진하는 미용건강식품으로서 진주가루를 함유하는 아름다운 피부촉진제에 관한 것이다.The present invention is a beauty health food containing pearl powder as ingestion of pearl powder, the pearl powder acts on the central nervous system to improve the moist and tightness of the skin and promote the prevention and improvement of skin roughness and fine wrinkles. It relates to a skin promoter.
초세진주 제품은 전통적인 명귀한 약재로서 인체에 필요한 20여종의 아미노산과 28종의 미량원소를 포함하며 미백 및 피부세포 재생효과가 뛰어난 피부미용 개선재료로 사용된다고 본토강목에 기록되어 있다. 또한, 동의보감의 외형편에는 진주를 가루로 만들어 유즙과 더불어 상시 바를 경우 검은 반점을 없에주고, 얼굴색을 곱고 윤택하게 해주며, 동의보감의 탕액편에는 진주는 마음과 정신을 진정시키고, 눈을 밟게 하며 피부를 젊어지게한다고 기록되어 있다. 진주가루는 게나 새우 등의 갑각류의 외각중에 포함되는 고분자다당류 키틴(chitin)을 분해하여 얻을수 있는 천연형 아미노당의 1종이며, 사탕의 약 2분의 1 정도의 양질의 감미를 갖는 흡습성이 적은 백색의 결정성 분말이다. 진주가루는 우유중에도 유리상태로 10mg/100ml 전후 포함되어 있고, 또 뮤코다당이나 당단백질, 당지질의 당쇄(糖鎖)부분의 구성단위로서 생체중에 보편적으로 존재하고 있다. 통상, 생체내에서는 글루코스를 출발물질로서 대사(代謝)에 의해 만들어내고 있으며, 사람에 있어서는 안전성이 높은 생체성분의 하나이다. 그리고 진주가루의 생리기능으로 관절염의 증상개선이나 비피도균의 증식촉진효과 등이 알려지고 있다.Ultra-fine pearl is a traditional and precious medicine that contains about 20 kinds of amino acids and 28 kinds of trace elements necessary for the human body, and it is recorded in the main hardwood that it is used as an improvement material for skin beauty with excellent whitening and skin cell regeneration effect. In addition, pearls are powdered on the outer side of Dongbobogam to remove black spots with regular milk, and the face color is multiplied and moisturized. It is said to rejuvenate the skin. Pearl powder is a type of natural amino sugar that can be obtained by decomposing high polysaccharide chitin contained in shells of crab and shrimp, etc., and has a low hygroscopic white color with a sweetness of about one half of candy. Is a crystalline powder. Pearl powder is contained in milk at around 10mg / 100ml in a free state, and is commonly present in the body as a structural unit of mucopolysaccharides, glycoproteins, and sugar chains of glycolipids. Usually, in vivo, glucose is produced as a starting material by metabolism, and it is one of high safety biological components in humans. In addition, the physiological function of pearl powder is known to improve the symptoms of arthritis and to promote the growth of nasal bacteria.
그러나, 진주가루를 구성하는 히알루론산, 콘드로이틴황산, 콜라겐 등은 고분자화합물로서, 중추신경계통의 기능에 대한 연구는 아직 알려져 있지 않은 상태이다. 즉, 중추신경계통에 대한 진통, 종양 방지등의 기능에 대한 영향에 대한 연구가 없어 히알루론산, 콘드로이틴황산, 콜라겐 등의 고분자화합물을 경구섭취한경우도, 그들의 소화·흡수성의 문제가 있어, 그 효과는 반드시 만족하게 되는 것은 아니었다.However, hyaluronic acid, chondroitin sulfate, collagen, and the like, which constitute pearl powder, are polymer compounds, and studies on the function of the central nervous system are not yet known. That is, even if there are no studies on the effects on the central nervous system, such as analgesic and tumor prevention, oral ingestion of high molecular compounds such as hyaluronic acid, chondroitin sulfate, and collagen also has problems with their digestion and absorption. Was not necessarily satisfied.
따라서, 본 발명의 목적은 진주가루를 입으로 섭취함으로써, 피부가 촉촉하고 팽팽한 것을 향상시키고, 피부의 거칠음이나 잔주름의 예방·개선이라 하는 작용을 갖는 진주가루를 함유하는 아름다운 피부촉진제를 제공하는데 있다.Accordingly, an object of the present invention is to provide a beautiful skin-promoting agent containing pearl powder having the action of preventing and improving skin roughness and fine wrinkles by ingesting pearl powder by mouth. .
상기 목적을 달성하기 위한 진주가루를 함유하는 아름다운 피부촉진제는 입으로 섭취한 진주가루가 내장관으로부터 신속히 흡수되어, 피부층에 도달되고, 피부층에 작용하여 히알루론산 등의 뮤코다당류의 생합성을 촉진하는 것이다.A beautiful skin promoting agent containing pearl powder for achieving the above object is that pearl powder taken by mouth is quickly absorbed from the intestinal tract, reaches the skin layer, and acts on the skin layer to promote biosynthesis of mucopolysaccharides such as hyaluronic acid. .
본 발명에 의하면, 아름다운 피부촉진제에 진주가루을 함유시켜 이것을 섭취하게 하므로서, 진주가루의 대부분이 신속히 흡수되고, 그 일부가 히알루론산이나 콘드로이틴황산 등의 산성뮤코다당류의 원료로서 이용되어 피부의 촉촉함과 팽팽함이 향상되고, 피부의 거칠음이나 잔주름 등을 예방·개선할 수 있다.According to the present invention, pearl powder is contained in a beautiful skin promoting agent and consumed, so that most of the pearl powder is quickly absorbed, and a part of it is used as a raw material of acidic mucopolysaccharides such as hyaluronic acid and chondroitin sulfate to moisturize and tighten the skin. This improves and can prevent and improve skin roughness and fine wrinkles.
본 발명의 진주가루를 함유하는 아름다운 피부촉진제에 따른 중추신경계에 작용하는 피부촉진제는 진주가루를 유효성분으로 한다. 상기 진주가루는 0.1 중량% 이상 함유한다.The skin promoting agent acting on the central nervous system according to the beautiful skin promoting agent containing pearl powder of the present invention contains pearl powder as an active ingredient. The pearl powder contains 0.1% by weight or more.
상기 진주가루의 형태는 정제, 캡슐제, 분말, 과립, 액 또는 페이스트이다.The pearl powder is in the form of tablets, capsules, powders, granules, liquids or pastes.
이하, 본 발명의 아름다운 피부촉진제의 바람직한 실시예를 들어서 상세히 설명한다.Hereinafter, a preferred embodiment of the beautiful skin promoter of the present invention will be described in detail.
본 발명에 있어서, 진주가루로서는, 게나 새우 등의 갑각류의 외각으로부터 유래하는천연다당류 키틴을 산 및 효소에 의해 가수분해하여 얻어지는 천연형 지주가루, 또는 키틴을 완전히 산가수분해하여 얻어지는 화학합성 진주가루를 사용할 수 있다.In the present invention, as pearl powder, natural polysaccharide chitin derived from shells of shellfish such as crabs and shrimps is obtained by acid and enzyme hydrolysis, or chemical synthetic pearl powder obtained by completely acid hydrolyzing chitin. Can be used.
본 발명에 있어서는 아름다운 피부촉진제중에 유효성분으로서 진주가루를 0.1∼100 중량% 함유하고 있는 것이 바람직하고, 1∼50 중량% 함유하고 있는것이 보다 바람직하다.In this invention, it is preferable to contain 0.1-100 weight% of pearl powder as an active ingredient in a beautiful skin promoter, and it is more preferable to contain 1-50 weight%.
본 발명의 보다 바람직한 실시예에 의하면, 진주가루와 상기 아름다운 피부효과를 갖는 성분을 함께 섭취할 수 있으므로, 아름다운 피부촉진의 상승효과를 기대할 수 있다. 또, 진주가루는 상기와 같은 다른 성분이 공존하고 있어도 착색, 분해나 반응 등을 일으키는 일도 없다.According to a more preferred embodiment of the present invention, since the pearl powder and the component having the beautiful skin effect can be ingested together, a synergistic effect of beautiful skin promotion can be expected. In addition, pearl powder does not cause coloring, decomposition, reaction, or the like even when other components described above coexist.
본 발명의 아름다운 피부촉진제의 섭취량은, 성인 1일당, 진주가루환산으로 0.1∼15g, 보다 바람직하게는 0.3∼5g이다. 진주가루의섭취량이 0.1g미만으로는 아름다운 피부촉진효과가 기대될 수 없기 때문에 바람직하지 않다. 또, 진주가루의 섭취량이 15g을 초과하면 체질에 의해 무른 대변, 설사 등의 증상이 나올 가능성이 있기 때문에 바람직하지 않다. 더욱이, 후술하는 시험예에 표시하는 바와 같이, 실험 쥐에 진주가루를 5g/체중kg 경구투여하여도 안전한 것을 확인하고 있다.The intake amount of the beautiful skin promoter of the present invention is 0.1 to 15 g, more preferably 0.3 to 5 g, in terms of pearl powder, per adult per day. If the intake of pearl powder is less than 0.1 g, it is not preferable because a beautiful skin promoting effect cannot be expected. In addition, when the intake of pearl powder exceeds 15g, symptoms such as soft stool and diarrhea may occur due to constitution, which is not preferable. Moreover, as shown in the test examples described later, it was confirmed that even when 5 g / kg body weight of pearl powder was orally administered to the experimental rats.
본 발명의 아름다운 피부촉진제의 형태로서는, 정제, 캡슐제, 분말, 과립(작은 알맹이), 액 또는 페이스트인 것이 바람직한다.As a form of the beautiful skin promoter of this invention, it is preferable that it is a tablet, a capsule, powder, granules (small kernels), a liquid, or a paste.
본발명의 진주가루가 중추신경 계통에 미치는 영향에 대한 실험에 있어서, 실험재료로서 약품은 진주가루, 백색가루(중국 소주시 수산연구소에서 제공한 실험시) 0.2 % CMC 로 혼합액을 만든다. 또 실험재료로서 동물은 18 -22 gr 의 곤명종 작은 쥐, 2 kgr 의 토끼( 소주시 의학원 동물실험 센터에서 제공)를 준비한다.In experiments on the effect of pearl powder on the central nervous system of the present invention, as an experimental material, the drug is made of 0.2% CMC with pearl powder and white powder (at the time of experiment provided by Suzhou Research Institute of Fisheries). In addition, as an experimental material, the animals prepare 18 -22 gr of Kunming small rats and 2 kgr of rabbits (provided by the Suzhou Medical Center Animal Experiment Center).
실험예 1 진통작용Experimental Example 1 Analgesic Action
첫째 열판법에 있어서, 40마리의 암컷쥐를 채용하여 0.2 % CMC 혼합액의 대조그룹과 600 mg/Kgr 의 진주분 그룹으로 분류한다. 먼저 섭씨온도 55 ± 1 의 뜨거운 판자위에서 쥐들의 기초진통(1.07 ±0.57)을 측정한다. 그리고, 쥐의 복부에진주가루 약물을 주사해 넣고 30분 60분, 120분, 180분, 240 분의 각 시간대 별로 쥐의 진통을 다음 표 1에서와 같이 측정한다.In the first hotplate method, 40 female mice were employed and classified into a control group of 0.2% CMC mixture and a pearl group of 600 mg / Kgr. First, basal labor (1.07 ± 0.57) of rats is measured on a hot board at 55 ± 1 degrees Celsius. Then, the injection of the powdered pearl powder in the rat's abdomen is measured in 30 minutes 60 minutes, 120 minutes, 180 minutes, 240 minutes each time the analgesic of the rat as shown in Table 1.
표 1에서 알 수 있는 바와 같이 진주가루의 투여량에 비례하여, 진통이 감소하는 경향이 인지되었다. 그 결과 진주가루는 명확한 진통작용이 있다는 것을 설명해 준다.As can be seen from Table 1, in proportion to the dose of pearl powder, a tendency to reduce analgesia was recognized. As a result, pearl powder has a clear analgesic effect.
둘째 대체법에 있어서, 암컷, 수컷 쥐60마리를 채용하여 대조그룹(0.2 %CMC 용액), 진주가루(300 mgr/Kgr), 사냉정그룹(200 mgr/Kgr)의 3개그룹으로 분류한다. 그리고 복부에 약물을 주사하고 그후 30후에 0.1 % 주석산화제를 주사해 넣는다. 그리고 30초 내에 쥐들이 몸을 비꼬는 회수를 관찰하고 기록한 바 그 결과를 표 2에 표시한다. 표 2에서 사망예는 인지되지 않았으며, 진통에 대한 가소현상이라고 인지되었다.In the second alternative method, 60 female and male rats were employed and classified into three groups: control group (0.2% CMC solution), pearl powder (300 mgr / Kgr), and saakjeong group (200 mgr / Kgr). Drugs are then injected into the abdomen, followed by injection of 0.1% tin oxidant 30 hours later. And within 30 seconds, the number of times the rats twist the body observed and recorded the results are shown in Table 2. In Table 2, deaths were not recognized and were reported to be plasticizers for analgesia.
표 2와 같은 진통 백분율이 낮아지는 결론을 얻는다. 표 2에서 알 수 있는 바와 같이, 반응이 일어난 동물수는 반응이 없는 동물수에 비교해서, 시험개시 이전에 비교하여 그 동물수가 줄어 들었다. 즉,진통 백분율이 낮아지는 결과를 얻었다. 이는 사람의 피부에 촉촉한 감이나 팽팽한 감을 느끼게 되었다 등, 전체적으로 피부의 상태가 좋게 되었다고 느낀 사람이 많고, 진주가루의 아름다운 피부효과가 인지될수 있다는 것을 알 수 있다.The conclusion is that the analgesic percentage shown in Table 2 is lowered. As can be seen in Table 2, the number of animals that reacted was reduced compared to the number of animals that did not respond, compared to the number of animals before the start of the test. In other words, the pain percentage was lowered. This can be seen that many people feel that the skin is in good condition, such as feeling moist or taut on human skin, and the beautiful skin effect of pearl powder can be recognized.
이상 설명한 바와 같이, 본 발명에 의하면, 피부 거칠음이나 잔주름 등을 예방·개선하는 진주가루를 함유한 피부촉진제를 얻을수가 있다. 그리고, 본 아름다운 피부 접촉제를 경구섭취함으로써, 진주가루가 신속히 흡수되어 중추신경계통에 작용하고, 중추신경계통에 작용으로 피부층으로 이행하여 히알루론산 등의 원료로 되고, 피부의 촉촉함과 팽팽함이 향상되어, 피부 거칠음이나 잔주름등을 예방·개선할 수 있다.As described above, according to the present invention, a skin promoter containing pearl powder for preventing and improving skin roughness, fine wrinkles, and the like can be obtained. In addition, by orally ingesting the beautiful skin contact agent, pearl powder is rapidly absorbed and acts on the central nervous system, and acts on the central nervous system to transfer to the skin layer and becomes a raw material such as hyaluronic acid, thereby improving the moist and tightness of the skin. This can prevent and improve skin roughness and fine wrinkles.
Claims (3)
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| Publication number | Priority date | Publication date | Assignee | Title |
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| KR20180033061A (en) * | 2017-09-06 | 2018-04-02 | 샘표식품 주식회사 | Methods for Improving Flavors of Fermented Vinegar and Composition for Improving Skin Conditions Comprising Pearl Fermentation Products Thereby |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60214857A (en) * | 1984-04-06 | 1985-10-28 | Inahata Koryo Kk | Healthy food |
| KR19980026114A (en) * | 1996-10-07 | 1998-07-15 | 이능희 | Cosmetic beverage composition containing freshwater pearl extract as main ingredient |
| KR0173429B1 (en) * | 1996-01-17 | 1999-02-01 | 이완진 | Process for preparation of pearl solution with physical, chemical and biochemical method |
| JPH11209225A (en) * | 1998-01-21 | 1999-08-03 | Leap:Kk | Usage of shellfish |
| KR19990073114A (en) * | 1999-05-18 | 1999-10-05 | 기승철 | Complex seasoning composition for food containing pearl powder. |
-
2002
- 2002-07-09 KR KR1020020039614A patent/KR20040006092A/en not_active Application Discontinuation
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60214857A (en) * | 1984-04-06 | 1985-10-28 | Inahata Koryo Kk | Healthy food |
| KR0173429B1 (en) * | 1996-01-17 | 1999-02-01 | 이완진 | Process for preparation of pearl solution with physical, chemical and biochemical method |
| KR19980026114A (en) * | 1996-10-07 | 1998-07-15 | 이능희 | Cosmetic beverage composition containing freshwater pearl extract as main ingredient |
| JPH11209225A (en) * | 1998-01-21 | 1999-08-03 | Leap:Kk | Usage of shellfish |
| KR19990073114A (en) * | 1999-05-18 | 1999-10-05 | 기승철 | Complex seasoning composition for food containing pearl powder. |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20180033061A (en) * | 2017-09-06 | 2018-04-02 | 샘표식품 주식회사 | Methods for Improving Flavors of Fermented Vinegar and Composition for Improving Skin Conditions Comprising Pearl Fermentation Products Thereby |
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