KR20000044978A - Enhancer composition for stratum cornea exfoliation - Google Patents

Enhancer composition for stratum cornea exfoliation Download PDF

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KR20000044978A
KR20000044978A KR1019980061485A KR19980061485A KR20000044978A KR 20000044978 A KR20000044978 A KR 20000044978A KR 1019980061485 A KR1019980061485 A KR 1019980061485A KR 19980061485 A KR19980061485 A KR 19980061485A KR 20000044978 A KR20000044978 A KR 20000044978A
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skin
isoserine
exfoliation
composition
weight
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박선규
이동건
김진준
강세훈
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성재갑
주식회사 엘지화학
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/31—Hydrocarbons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/345—Alcohols containing more than one hydroxy group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/361—Carboxylic acids having more than seven carbon atoms in an unbroken chain; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37—Esters of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q1/00—Make-up preparations; Body powders; Preparations for removing make-up
    • A61Q1/02—Preparations containing skin colorants, e.g. pigments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q1/00—Make-up preparations; Body powders; Preparations for removing make-up
    • A61Q1/14—Preparations for removing make-up
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/10—Washing or bathing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A61Q5/02—Preparations for cleaning the hair

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
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  • Dermatology (AREA)
  • Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Cosmetics (AREA)

Abstract

PURPOSE: An enhancer composition for stratum cornea exfoliation has intensive exfoliation effect, consequently reduces hyperkeratinization and relieves side effect like sting by comprising isoserine. CONSTITUTION: 0.01-10 wt.% of isoserine(3-amino-2-hydroxypropionic acid) having molecular weight of 105, desirably 0.1-5 wt.% is added in the enhancer composition for stratum cornea exfoliation based on the total dried weight of the composition at room temperature. The isoserine is propionic acid derivative having hydroxy group at carbon number 2 and amine group at carbon number 3 and it is not known if it is available from nature.

Description

각질 박리 촉진용 조성물Composition for promoting keratin exfoliation

본 발명은 각질 박리 촉진용 조성물에 관한 것이다. 더욱 상세하게는 이소세린(isoserine)(3-amino-2-hydroxypropionic acid: COOHCHOHCH2NH2)을 함유함으로써, 종래의 알파하이드록시산(AHA)보다 피부 따가움이 적고, 각질 박리 촉진 효과가 우수한 조성물에 관한 것이다.The present invention relates to a composition for promoting exfoliation. More specifically, by containing isoserine (3-amino-2-hydroxypropionic acid: COOHCHOHCH 2 NH 2 ), the composition has less skin tingling and excellent exfoliation promoting effect than conventional alpha hydroxy acid (AHA). It is about.

일반적으로 피부는 피부 상층부터 표피, 진피, 피하 지방 층의 세 부분으로 분류된다. 이중 표피는 다시 각질층, 과립층, 유극층, 기저층으로 세분되며, 기저층의 표피 세포는 피부 상부로 올라오면서 분화되어, 최종적으로 각질층에 도달하게 된다. 각질층에 도달한 표피 세포는 핵이 소실되고, 케라틴(keratin)이라고 하는 불수용성 단백질로 채워지면서 죽은 세포로 전환된다. 각질층은 분화된 표피 세포(각질 세포)와 이들 사이를 채워 주는 피부 지질(skin lipid)로 구성되는데, 이것은 체내 물질이 외부로 나가는 것을 막아주고, 외부의 물리적, 화학적 및 생물학적 자극으로부터 인체를 보호하는 방어 기능을 한다. 각질 세포는 데스모좀(desmozom)이라고 하는 단백질에 의하여 연결되어 있고, 각질층 상부로 올라갈수록 데스모좀은 분해되어 각질 세포간 응집력이 약화되고, 결국 각질 세포는 피부로부터 분리되어 떨어져 나간다. 정상 피부의 경우 각질층은 15 내지 20 개의 층으로 구성되고, 이들이 완전히 분리되는데는 15 내지 20 일이 소요(Britsh J. of Dermatology, 86, 14-19, 1974; K.M.Halprin, 향장회지, 12(4), 265-271, 1988; M.Takahashi )되므로 하루에 약 1층의 각질 세포층이 떨어져나간다. 노화 피부, 건조 피부, 여드름 피부 등은 각질층의 분리가 정상보다 늦어져 각질층이 두꺼워지는 각질 중층화 현상을 보이고, 이 경우 피부 외관상으로 나타나는 두드러진 특징은 피부 비늘(scale)의 발생이다.Generally, the skin is divided into three parts: the upper layer of skin, the epidermis, the dermis, and the subcutaneous fat layer. The double epidermis is further subdivided into stratum corneum, granule layer, pole layer, and basal layer. The epidermal cells of the basal layer are differentiated as they rise to the upper part of the skin and finally reach the stratum corneum. Epidermal cells that reach the stratum corneum lose their nuclei and are converted to dead cells as they are filled with an insoluble protein called keratin. The stratum corneum consists of differentiated epidermal cells (skin cells) and skin lipids that fill between them, which prevents the release of substances in the body and protects the body from external physical, chemical and biological stimuli. It acts as a defense. The keratinocytes are connected by a protein called desmozom, and as they rise up the stratum corneum, the desmosome is broken down to weaken the cohesion between keratinocytes and eventually the keratinocytes separate from the skin and fall off. For normal skin, the stratum corneum consists of 15 to 20 layers, and it takes 15 to 20 days for them to be completely separated (Britsh J. of Dermatology, 86, 14-19, 1974; KMHalprin, Perilla, 12 (4 ), 265-271, 1988; M.Takahashi), thus leaving about one layer of keratinocytes per day. Aging skin, dry skin, acne skin and the like, the separation of the stratum corneum is normal, thickening of the stratum corneum thickening phenomenon, in this case, the outstanding feature that appears in the appearance of the skin is the development of skin scale (scale).

각질 중층화는 주로 피부의 보습력 감소, 데스모좀 분해 효소의 생성 및 활성 감소, 세포 활성 저하 등에 기인하며, 피부 노화, 자외선 노출, 공해 등이 유발 요인이 된다. 상기한 내적ㆍ 외적 요인에 의해 두꺼워진 각질층을 외부에서 인위적으로 얇게 해주면, 각질층 밑에 있는 살아있는 세포의 활성 혹은 재생이 증가되어 피부외관에 나타나는 피부 비늘이 감소하고, 피부가 부드러워지는 효과가 있어 자극이 유발되지 않는 범위 내에서 각질 중층화를 해소하려는 연구가 많이 진행되고 있다.The stratum corneum stratification is mainly due to decreased skin moisturizing power, decreased production and activity of desmosome degrading enzymes, decreased cell activity, and skin aging, UV exposure, and pollution. Artificially thinning the stratum corneum thickened by the above-mentioned internal and external factors from the outside artificially increases the activity or regeneration of living cells under the stratum corneum, reducing skin scales appearing in the skin appearance and softening the skin. There is a lot of research to solve the keratin stratification within the range that does not cause.

각질 중층화를 해소하기 위해서는 피부를 물리적으로 문지르거나 화학적 박피술을 이용한다. 특히 화학적 박피는 잔주름 개선, 거친 피부 완화, 잡티 제거 등의 부가적인 효과가 있다. 화학적 박피에 사용되는 물질로는 트리클로로아세트산, 페놀, 알파하이드록시산(AHA) 등이 있다. 화학적 박피에 이용되는 알파하이드록시산의 농도는 적어도 20 내지 30 % 이상의 고농도가 이용되나, 10 % 미만의 저농도에서는 각질층을 서서히 박리시키고( J.AM.Acad.Dermatol., 11, 867-879, 1984; Van Scott 등), 피부 보습 증진(happi, jully, 66-68, 1994; Tom 등), 잔주름 완화(Cutis, 43, 222-228, 1989; Van Scott 등) 등의 효과도 보여 최근 화장품이나 제약업계에서 많은 제품들이 출시되고 있다. 그러나 알파하이드록시산은 pH가 낮은 경우 피부의 따가움을 야기시키고 자극을 유발하는 단점도 있기 때문에 사용 농도와 pH 조절이 피부 부작용을 완화하는데 매우 중요하다. 또한 알파하이드록시산에 단백질, 지질 등을 붙이거나 부작용 완화제의 첨가, 구조 변경 등을 시도하여 피부 부작용을 감소시킬 수 있으나, 각질 박리, 잔주름 개선 등의 효과 또한 감소되어 최소의 부작용과 최대의 효과를 얻을 수 없다는 문제점이 있다.To relieve keratinization, physically rub the skin or use chemical dermabrasion. In particular, chemical peels have additional effects such as fine wrinkles, rough skin relief and blemishes. Substances used for chemical peeling include trichloroacetic acid, phenol, and alpha hydroxy acid (AHA). The concentration of alpha hydroxy acid used for chemical peeling is used at a high concentration of at least 20-30%, but at low concentrations of less than 10%, the stratum corneum is slowly peeled off (J.AM.Acad.Dermatol., 11, 867-879, 1984; Van Scott et al.), Enhancing skin moisturization (happi, jully, 66-68, 1994; Tom et al.), And reducing fine lines (Cutis, 43, 222-228, 1989; Van Scott et al.). Many products are released in the pharmaceutical industry. However, alpha-hydroxy acid has a disadvantage of causing skin irritation and irritation when the pH is low, so use concentration and pH control are very important to alleviate side effects of the skin. In addition, it is possible to reduce skin side effects by attaching proteins, lipids, etc. to alpha hydroxy acids, or by adding side effect relievers or structural changes, but the effects such as exfoliation and fine wrinkles are also reduced to minimize side effects and maximum effects. There is a problem that can not be obtained.

본 발명은 상기한 문제점을 해결하기 위한 것으로서, 이소세린(3-amino-2-hydroxypropionic acid)을 유연 화장수, 영양 화장수, 영양 크림, 맛사지 크림, 엣센스, 팩 등의 화장료, 비누, 폼 클렌징, 바디 클린저, 샴푸, 린스 등의 피부 및 모발 세정제 및 피부 외용 연고에 첨가함으로써, 피부 따가움 등의 부작용이 없고 각질 박리 촉진 효과가 우수한 각질 박리 촉진용 조성물을 제공하는 것이다.The present invention is to solve the above problems, isocerine (3-amino-2-hydroxypropionic acid), such as flexible lotion, nourishing lotion, nourishing cream, massage cream, essence, pack and other cosmetics, soap, foam cleansing, body By adding it to skin and hair cleansers, such as a cleanser, a shampoo, a rinse, and an ointment for external skin, it provides the composition for exfoliation promotion excellent in the exfoliation promoting effect, without the side effect, such as skin tingling.

상기와 같은 목적을 달성하기 위하여 본 발명은 이소세린을 전체 조성물에 대하여 건조 중량으로 0.01 내지 10 중량% 함유하는 각질 박리 촉진용 조성물을 제공한다.In order to achieve the above object, the present invention provides a composition for promoting keratin exfoliation containing isocerine in a dry weight of 0.01 to 10% by weight based on the total composition.

이하, 본 발명을 상세히 설명하면 다음과 같다.Hereinafter, the present invention will be described in detail.

이소세린(3-amino-2-hydroxypropionic acid)은 분자량 105의 수용성 물질이며, 2번 탄소위치에 하이드록실기가 3번탄소 위치에 아민기가 붙은 프로피오닉산 유도체이나, 현재까지 천연적으로 존재하는 물질로 알려진 바는 없다. 이소세린을 유연 화장수, 영양 화장수, 영양 크림, 맛사지 크림, 엣센스, 팩 등을 포함한 화장료, 비누, 폼 클렌징, 바디 클린저, 샴푸, 린스 등을 포함한 피부 및 모발 세정제 및 피부 외용 연고에 첨가한다. 상기 이소세린의 첨가량은 전체 조성물에 대하여 건조 중량으로 0.01 내지 10 중량%, 바람직하게는 0.1 내지 5 중량%이다. 이소세린의 첨가량이 전체 조성물에 대하여 건조 중량으로 0.01 중량% 미만이면 각질 박리 촉진의 충분한 효과가 나타나지 않고, 10 중량%를 초과하면 각질 박리 효과가 더 이상 향상되지 않을 뿐만 아니라, 또한 제형 및 제품 안정성에 해로운 영향을 미친다. 상기 이소세린의 첨가는 상온에서 수행한다.Isoserine (3-amino-2-hydroxypropionic acid) is a water-soluble substance having a molecular weight of 105, a propionic acid derivative having a hydroxyl group at the carbon position of 2 and an amine group at the carbon position of 3, but is naturally present None known. Isoserine is added to skin and hair cleansers and external cosmetic ointments, including flexible lotions, nourishing lotions, nourishing creams, massage creams, essences, packs, cosmetics including soaps, foam cleansing, body cleansers, shampoos, rinses, and the like. The amount of isoserine added is 0.01 to 10% by weight, preferably 0.1 to 5% by weight, based on the dry weight of the total composition. If the amount of isoserine added is less than 0.01% by weight in dry weight with respect to the whole composition, there is no sufficient effect of promoting keratin exfoliation, and if it is more than 10% by weight, the exfoliation effect no longer improves, and also the formulation and product stability Has a detrimental effect on The addition of the isoserine is performed at room temperature.

상기에서 제조된 이소세린이 함유된 화장료, 피부 및 모발세정제 및 피부 외용 연고를 사람의 피부에 적용하여 각질 박리 효과 및 따가움 정도 등을 시험한다. 또한, 상기 이소세린이 함유된 화장료 등을 제조하기 전에 먼저, 이소세린의 각질 박리 효과와 피부 따가움 등의 부작용 정도 여부를 종래의 글리콜산 및 락산과 비교하는 실험을 수행한다.Isomerine-containing cosmetics, skin and hair cleansers and external skin ointments prepared above are applied to human skin to test the exfoliation effect and the degree of tingling. In addition, before preparing the cosmetics containing the isoserine, first, an experiment is performed to compare the degree of side effects such as exfoliation effect and skin tingling of isoserine with conventional glycolic acid and lactic acid.

다음은 본 발명의 이해를 돕기 위하여 바람직한 실시예 및 비교예를 제시한다. 그러나 하기의 실시예들은 본 발명을 보다 쉽게 이해하기 위하여 제공되는 것일 뿐 본 발명이 하기의 실시예에 한정되는 것은 아니다.The following presents preferred examples and comparative examples to aid in understanding the invention. However, the following examples are merely provided to more easily understand the present invention, and the present invention is not limited to the following examples.

실험예 1:알파하이드록시산 및 이소세린의 각질박리 효과 비교Experimental Example 1: Comparison of the exfoliation effect of alpha hydroxy acid and isoserine

미국 시그마(Sigma)사에서 제조되는 이소세린을 사용하여 각질 박리 촉진 효과를 측정하였다. 피시험자는 20세에서 40세 사이의 건강한 남성 30명을 대상으로 실시하였다. 시료(알파하이드록시산 또는 이소세린) 도포 전 피시험자의 팔 상박부 안쪽 색상을 크로마 미터(Chroma meter)(CR-200, Minolta, 일본 )로 측정한 후, 10 % 농도의 디히드록시 아세톤(Dihydroxy acetone: DHA) 약 0.4 ml를 힐 톱 챔버(Hill top chamber; The Hill Top Companies)에 넣고, 팔 상박부 안쪽에 6시간 동안 부착하였다. 24시간 경과 후, DHA에 의해 갈색으로 착색된 부위의 색상을 측정하여 시료 도포 전과의 색상 차이를 비교하였다. 이 후 1일 2회씩 시료를 도포 하면서 매일 탈색되는 정도를 크로마 미터로 측정하여 원래의 피부색으로 돌아오는데 걸리는 시간을 측정하였다. 또한, 각질 박리율은 하기 식으로 계산하였고, 그 결과를 하기 표 1 및 2에 나타내었다.Isoserine manufactured by Sigma, USA was used to measure the exfoliation promoting effect. The test subjects were 30 healthy males between 20 and 40 years old. Before applying the sample (alpha hydroxy acid or isoserine), the color of the inner upper arm of the test subject was measured with a chroma meter (CR-200, Minolta, Japan), followed by dihydroxy acetone (10% concentration). Approximately 0.4 ml of dihydroxy acetone (DHA) was placed in a Hill top chamber (The Hill Top Companies) and attached to the inside of the upper arm for 6 hours. After 24 hours, the color of the brown colored area was measured by DHA to compare the color difference with that before the sample application. Thereafter, while applying the sample twice a day, the degree of discoloration was measured by a chromameter every day, and the time taken to return to the original skin color was measured. In addition, the keratin peeling rate was calculated by the following formula, the results are shown in Tables 1 and 2.

각질 박리율(%) = (Blank의 TT*- 시료도포시 TT)/Blank의 TT ×100Keratin peel rate (%) = (Blank TT * -TT for sample application) / Blank TT × 100

(*: TT(Turnover Time)는 기존의 각질층이 새로운 각질층으로 대체되는데 걸리는 시간을 의미하는데, 본 실험에서는 DHA에 의해 착색된 피부가 완전히 원상 복귀되는데 걸리는 시간을 의미함).(*: TT (Turnover Time) refers to the time it takes for the old stratum corneum to be replaced by a new stratum corneum, which in this experiment refers to the time it takes for the skin colored by DHA to fully revert).

기존의 알파하이드록시산과 이소세린의 각질박리 효과 비교Comparison of Exfoliation Effect of Conventional Alpha-hydroxy Acid and Isoserine 시료의 종류Type of sample Turnover Time(days)Turnover Time (days) 각질박리율Exfoliation rate Blank* Blank * 17.6 ± 3.217.6 ± 3.2 -- 대조군(SCL**)Control (SCL ** ) 16.6 ± 5.616.6 ± 5.6 5.6%5.6% Glycolic acid 5%Glycolic acid 5% 13.8 ± 4.513.8 ± 4.5 21.6%21.6% Lactic acid 5%Lactic acid 5% 14.0 ± 4.114.0 ± 4.1 20.5%20.5% lsoserine 5%lsoserine 5% 10.6 ± 1.710.6 ± 1.7 39.8%39.8%

Blank*: DNA로 착색 후 아무 시료도 바르지 않은 군.Blank * : No sample applied after staining with DNA.

SCL**(simple cosmetic liquid):피부에 도포성을 높이기 위하여 사용되는 용 매(물:에탄올:1.3-부틸렌글리콜의 비가 80:15:5)로서, 본 각질 박리 실 험예에 사용되는 모든 시료는 SCL에 용해시켜 사용하였다.SCL ** (simple cosmetic liquid): A solvent (water: ethanol: 1.3-butylene glycol ratio of 80: 15: 5) used to enhance applicability to the skin. All samples used in this exfoliation test example. Was dissolved in SCL and used.

상기 표 1에서 보는 바와 같이 우수한 각질 박리제로 알려진 글리콜산( Glycolic acid )과 젖산(Lactic acid)은 5 % 농도 사용시 약 20 % 정도의 각질 박리 효과를 보였으나, 동일한 농도의 이소세린은 상기 두 알파하이드록시산보다 약 2배인 39.8%의 각질 박리 효과를 보였다.As shown in Table 1, glycolic acid (Glycolic acid) and lactic acid (Lactic acid), which are known as excellent exfoliants, showed about 20% exfoliation effect when the 5% concentration was used. It showed a 39.8% exfoliation effect, which is about twice as much as hydroxy acid.

농도에 따른 이소세린의 각질박리 효과Exfoliation Effect of Isoserine with Different Concentrations 시료의 종류Type of sample Turnover Time(days)Turnover Time (days) 각질박리율Exfoliation rate BlankBlank 17.6 ± 3.217.6 ± 3.2 -- 대조군(SCL)Control (SCL) 16.6 ± 5.616.6 ± 5.6 5.6%5.6% lsoderine 10%lsoderine 10% 8.7 ± 1.98.7 ± 1.9 50.6%50.6% lsoserine 5%lsoserine 5% 10.6 ± 1.710.6 ± 1.7 39.8%39.8% lsoserine 2%lsoserine 2% 14.3 ± 2.414.3 ± 2.4 18.8%18.8% lsoserine 1%lsoserine 1% 14.9 ± 3.514.9 ± 3.5 15.3%15.3% lsoserine 0.1%lsoserine 0.1% 15.9 ± 4.815.9 ± 4.8 9.7%9.7% lsoserine 0.01%lsoserine 0.01% 16.2 ± 6.116.2 ± 6.1 7.9%7.9%

상기 표 2에서 보는 바와 같이 이소세린의 농도가 10 % 이상일 경우 50 %이상의 각질 박리 효과를 보였고, 0.1 % 이하의 농도에서는 10 % 미만의 각질 박리 효과를 보였다.As shown in Table 2, when the concentration of isoserine was 10% or more, the keratin exfoliation effect was 50% or more, and at the concentration of 0.1% or less, the keratin exfoliation effect was less than 10%.

실험예 2:알파하이드록시산 및 이소세린의 피부 따가움 유발 시험Experimental Example 2: Skin tingling test of alpha hydroxy acid and isoserine

각질 박리 효과가 우수한 이소세린을 사용하여 피부 따가움 유발 정도(sting test)를 측정하였다. 피시험자는 20세에서 35세 사이의 건강한 여성 30명을 대상으로 실시하였다. 먼저 세안을 하여 기존에 분비된 피지 및 먼지 등을 제거한 후, 항온 항습실(27 ℃, 70 %의 상대습도)에서 15분간 적응시켰다. 부직포에 시료(알파하이드록시산 또는 이소세린) 약 0.4 ml를 적신 후, 코 주변과 뺨에 부직포를 붙인 후, 20초 경과 후 제거하였다. 시간대 별(부직포 제거 후, 경과 시간 10초, 150초, 300초 및 480초)로 하기 따가움 정도 점수 기준과 하기 표 3의 따가움 정도 판단 기준에 의해 피시험자의 주관적 판정으로 따가움 정도를 측정하고, 그 결과를 하기 표 4에 나타내었다.Skin sting test was measured using isoserine having excellent exfoliation effect. The test subjects were 30 healthy women aged 20 to 35 years. First, after washing the face, the sebum and dust secreted previously were removed, and then adjusted for 15 minutes in a constant temperature and humidity room (27 DEG C, 70% relative humidity). About 0.4 ml of the sample (alpha hydroxy acid or isoserine) was soaked in the nonwoven fabric, and the nonwoven fabric was attached to the periphery of the nose and the cheeks and then removed after 20 seconds. The degree of tingling was measured by subjective judgment by the subject's subjective judgment based on the following degree of severity score and the severity determination criteria of Table 3 below for each time zone (after removing the nonwoven fabric, elapsed time 10 seconds, 150 seconds, 300 seconds, and 480 seconds). The results are shown in Table 4 below.

따가움 정도 판단 기준Stinging standard 따가움 정도 점수Stinging score 판단 기준Judgment 0.0 - 0.30.0-0.3 따가움 유발능이 없음No stinging effect 0.4 - 1.00.4-1.0 약간 따가움을 유발 함Slightly stingy 1.1 - 2.01.1-2.0 따가움을 유발함Stinging 2.1 - 3.02.1-3.0 심한 따가움을 유발함Causes severe stinging

* 따가움 정도 점수(sting score)기준:* Based on sting score:

0: 아무런 느낌이 없다. 1: 미미하게 따끔거린다.0: There is no feeling. 1: I sting slightly.

2: 확연히 따끔거린다. 3: 심하게 따끔거린다.2: I am quite stinging. 3: I feel badly tingling.

시료 적용에 따른 따가움 정도 점수Stinginess score according to sample application 물water 5% 글리콜산5% glycolic acid 5% 젖산5% Lactic Acid 5% 이소세린5% Isoserine 시간(초)Time in seconds 1010 150150 300300 480480 1010 150150 300300 480480 1010 150150 300300 480480 1010 150150 300300 480480 시간별 점수Hourly score 0.10.1 0.20.2 0.10.1 0.10.1 1.91.9 2.52.5 2.42.4 1.51.5 1.81.8 2.22.2 2.22.2 1.61.6 0.50.5 1.01.0 0.80.8 0.40.4 점수 평균Score average 0.130.13 2.082.08 1.951.95 0.680.68

상기 표 4에서 보는 바와 같이 이소세린은 동일한 농도의 글리콜산과 젖산보다 낮은 따가움 정도를 보였다.As shown in Table 4, isoserine showed a lower degree of stinging than glycolic acid and lactic acid at the same concentration.

상기에서 보는 바와 같이 종래의 알파하이드록시산에 비해 각질 박리 효과가 우수하고 낮은 따가움 정도를 가지는 이소세린을 사용하여 피부 외용 연고, 엣센스 및 영양 크림을 제조하였다.As described above, the skin external ointment, essence and nourishing cream were prepared using isoserine having superior exfoliation effect and low stinginess compared to conventional alpha hydroxy acids.

실시예 1Example 1

이소세린과 하기 표 5에 나타낸 각각의 성분을 하기 표 5에 나타난 비율과 같이 혼합하여 피부 외용 연고를 제조하였다.Isoserine and each of the components shown in Table 5 were mixed in the proportions shown in Table 5 below to prepare an external skin ointment.

피부외용연고Skin Ointment 중량%weight% 이소세린Isoserine 5.05.0 디에틸세바케이트Diethyl sebacate 8.08.0 경납Prepayment 5.05.0 폴리옥시에틸렌올레일-에테르 포스페이트(EO 4)Polyoxyethylene Oleyl-Ether Phosphate (EO 4) 6.06.0 벤조산 나트륨Sodium benzoate 적량Quantity 바세린Vaseline 잔량*Remaining amount * 계system 100100

*: 전체가 100 중량%가 되도록 하는 양*: Amount to be 100% by weight in total

실시예 2Example 2

이소세린과 하기 표 6에 나타낸 각각의 성분을 하기 표 6에 나타난 비율과 같이 혼합하여 엣센스를 제조하였다.Essence was prepared by mixing isoserine and each component shown in Table 6 below in the ratio shown in Table 6 below.

엣센스Essence 중량%weight% 이소세린Isoserine 22 농글리세린Concentrated glycerin 1010 프로필렌글리콜Propylene glycol 1010 폴리옥시에틸렌경화피마자유(E040)Polyoxyethylene Cured Castor Oil (E040) 1.01.0 히알우론산나트륨수용액(1%)Sodium hyaluronate aqueous solution (1%) 5.05.0 에탄올ethanol 5.05.0 방부제antiseptic 적량Quantity 향료Spices 적량Quantity 색소Pigment 적량Quantity 정제수Purified water 잔량*Remaining amount * 계system 100100

*: 전체가 100 중량%가 되도록 하는 양*: Amount to be 100% by weight in total

실시예 3Example 3

이소세린과 하기 표 7에 나타낸 각각의 성분을 하기 표 7에 나타난 비율과 같이 혼합하여 영양 크림을 제조하였다.Isoserine and each of the ingredients shown in Table 7 were mixed in the proportions shown in Table 7 below to prepare a nourishing cream.

영양크림Nutrition Cream 중량%weight% 이소세린Isoserine 1.01.0 스테아릴알콜Stearyl alcohol 6.06.0 스테아린산Stearic acid 2.02.0 농글리세린Concentrated glycerin 1.01.0 스쿠알란Squalane 9.09.0 1,3-부틸렌글리콜1,3-butylene glycol 6.06.0 폴리솔베이트 60Polysorbate 60 1.51.5 폴리에틸렌글리콜 1000Polyethylene Glycol 1000 4.04.0 경화 라놀린Cured Lanolin 4.04.0 옥틸 도데카놀Octyl dodecanol 10.010.0 솔비탄 스테아레이트Sorbitan Stearate 0.80.8 트리에탄올아민Triethanolamine 0.50.5 방부제antiseptic 적량Quantity 향료Spices 적량Quantity 색소Pigment 적량Quantity 정제수Purified water 잔량*Remaining amount * 계system 100100

*: 전체가 100 중량%가 되도록 하는 양*: Amount to be 100% by weight in total

실험예 3Experimental Example 3

상기 실시예1-3에서 제조된 피부 외용 연고, 엣센스 및 영양 크림에 대하여 각질 벽리 효과 및 따가움 시험을 수행하여 그 결과를 하기 표 8에 나타내었다.The skin external ointment, essence and nourishing cream prepared in Example 1-3 were subjected to keratin walling effect and stinging test and the results are shown in Table 8 below.

이소세린을 함유한 제형의 각질 박리 효과 및 따가움 측정Determination of keratin exfoliation effect and stinging of isoserine-containing formulations 각질박리율(%)Exfoliation rate (%) 따가움 점수(평균)Sting Score (Average) 실시예 1Example 1 4141 0.850.85 실시예 2Example 2 1717 0.390.39 실시예 3Example 3 1313 0.230.23

상기 표 8에서 보는 바와 같이 본 발명의 이소세린을 함유하는 화장료, 피부 및 모발세정제 및 피부 외용 연고는 우수한 각질 박리 촉진 효과를 나타내고, 피부 따가움 등의 부작용도 낮게 나타남을 알 수 있다.As shown in Table 8, it can be seen that the cosmetic, skin and hair cleansing agent and external skin ointment containing the isoserine of the present invention show excellent exfoliation promoting effect and low side effects such as skin stinging.

본 발명의 각질 박리 촉진용 조성물은 이소세린을 유연 화장수, 영양 화장수, 영양 크림, 맛사지 크림, 엣센스, 팩 등의 화장료, 비누, 폼 클렌징, 바디 클린저, 샴푸, 린스 등의 피부 및 모발 세정제 및 피부 외용 연고에 첨가함으로써, 피부 따가움 등의 부작용이 적고, 각질 박리 촉진 효과가 우수하다.The composition for promoting keratin exfoliation of the present invention isoserine, such as a flexible lotion, nourishing lotion, nourishing cream, massage cream, essences, cosmetics, such as packs, soaps, foam cleansing, body cleanser, shampoo, rinse, skin and hair cleansers and skin By adding it to an external ointment, there are few side effects, such as skin itching, and it is excellent in the exfoliation promoting effect.

Claims (5)

이소세린(3-amino-2-hydroxypropionic acid)을 전체 조성물에 대하여 건조 중량으로 0.01 내지 10 중량% 함유하는 각질 박리 촉진용 조성물.A composition for promoting keratin exfoliation containing isocerine (3-amino-2-hydroxypropionic acid) in a dry weight of 0.01 to 10% by weight based on the total composition. 제1항에 있어서,The method of claim 1, 상기 조성물의 제형은 기초 및 색조 화장료, 피부 세정제, 모발 세정제 및 피부 외용 연고로 이루어진 군에서 선택되는 어느 하나인 각질 박리 촉진용 조성물.Formulation of the composition is a composition for promoting keratin exfoliation is any one selected from the group consisting of basic and color cosmetics, skin cleaner, hair cleaner and skin ointment. 제2항에 있어서,The method of claim 2, 상기 기초 화장료가The basic cosmetics 이소세린 1.0 내지 3.0 중량%;Isocerine 1.0 to 3.0 wt%; 농글리세린 5.0 내지 15.0 중량%;Concentrated glycerin 5.0-15.0 wt%; 프로필렌 글리콜 5.0 내지 15.0 중량%;Propylene glycol 5.0-15.0 wt%; 폴리옥시에틸렌겨오가피마자유 0.1 내지 2.0 중량%;0.1-2.0 wt% of polyoxyethylene gyoza castor oil; 1% 히알우론산나트륨 수용액 1 내지 10.0 중량%;1 to 10.0% by weight aqueous 1% sodium hyaluronate solution; 에탄올 1 내지 10.0 중량%; 및Ethanol 1-10.0 wt%; And 물 33.0 내지 86.9 중량%Water 33.0-86.9 wt% 를 함유하는 엣센스.Essence containing. 제2항에 있어서,The method of claim 2, 상기 기초 화장료가The basic cosmetics 이소세린 0.1 내지 3.0 중량%;Isoserine 0.1-3.0 wt%; 스테아릴알콜 2.0 내지 10.0 중량%;Stearyl alcohol 2.0-10.0 wt%; 스테아린산 1.0 내지 3.0 중량%;1.0 to 3.0 wt% stearic acid; 농글리세린 0.1 내지 3.0 중량%;0.1% to 3.0% by weight of concentrated glycerin; 스쿠알란 5.0 내지 15.0 중량%;Squalane 5.0 to 15.0 wt%; 1,3-부틸렌글리콜 1.0 내지 10.0 중량%;1.0-10.0 wt% of 1,3-butylene glycol; 폴리솔베이트 60 0.1 내지 5.0 중량%;Polysorbate 60 0.1-5.0 wt%; 폴리에틸렌글리콜 1000 1.0 내지 10.0 중량%;Polyethylene glycol 1000 1.0-10.0 wt%; 경화 라놀린 1.0 내지 8.0 중량%;1.0 to 8.0 wt% cured lanolin; 옥틸 도데카놀 5.0 내지 15.0 중량%;Octyl dodecanol 5.0-15.0 wt%; 솔비탄 스테아레이트 0.1 내지 2.0 중량%;Sorbitan stearate 0.1-2.0 wt%; 트리에탄올아민 0.1 내지 1.0 중량%; 및0.1 to 1.0 wt% triethanolamine; And 물 15.0 내지 83.5 중량%15.0 to 83.5 wt% of water 를 함유하는 영양 크림.Nourishing cream containing. 제2항에 있어서,The method of claim 2, 상기 조성물의 제형이The formulation of the composition 이소세린 1.0 내지 10.0 중량%;Isoserine 1.0-10.0 wt%; 디에틸세바케이트 2.0 내지 15.0 중량%;Diethyl sebacate 2.0-15.0 wt%; 경납 1.0 내지 10.0 중량%;1.0 to 10.0 weight percent of braze; 폴리옥시에틸렌올레일-에테르 포스페이트 1.0 내지 11.0 중량%; 및1.0 to 11.0 weight percent polyoxyethylene oleyl-ether phosphate; And 바세린 54.0 내지 95.0 중량%Vaseline 54.0-95.0 wt% 를 함유하는 피부 외용 연고.Ointment for external use of the skin.
KR1019980061485A 1998-12-30 1998-12-30 Enhancer composition for stratum cornea exfoliation KR20000044978A (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100513301B1 (en) * 2002-04-03 2005-09-09 주식회사 인섹트 바이오텍 A composition for washing foot
KR20160042294A (en) 2014-10-08 2016-04-19 이현기 Cosmetic Composition for removing keratin comprising cultures of novel microorganism separated from carnivorous plants

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4547492A (en) * 1983-08-15 1985-10-15 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai 1-N-(ω-Amino-α-hydroxyalkanoyl-2',3'-dideoxykanamycin A and pharmaceutical composition containing same
WO1994003431A1 (en) * 1992-08-07 1994-02-17 Leo Pharmaceutical Products Ltd. A/S (Løvens Kemiske Fabrik Produktionsaktieselskab) Isoserine derivatives and their use as leukotriene antagonists
KR19980080965A (en) * 1997-03-31 1998-11-25 겐마아끼라 Collagen degradation promoter or keratin exfoliation accelerator
JPH1171224A (en) * 1997-08-29 1999-03-16 Shiseido Co Ltd Skin preparation for external use for preventing obscurity
KR19990040469A (en) * 1997-11-18 1999-06-05 손경식 Skin cosmetic composition

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4547492A (en) * 1983-08-15 1985-10-15 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai 1-N-(ω-Amino-α-hydroxyalkanoyl-2',3'-dideoxykanamycin A and pharmaceutical composition containing same
WO1994003431A1 (en) * 1992-08-07 1994-02-17 Leo Pharmaceutical Products Ltd. A/S (Løvens Kemiske Fabrik Produktionsaktieselskab) Isoserine derivatives and their use as leukotriene antagonists
KR19980080965A (en) * 1997-03-31 1998-11-25 겐마아끼라 Collagen degradation promoter or keratin exfoliation accelerator
JPH1171224A (en) * 1997-08-29 1999-03-16 Shiseido Co Ltd Skin preparation for external use for preventing obscurity
KR19990040469A (en) * 1997-11-18 1999-06-05 손경식 Skin cosmetic composition

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100513301B1 (en) * 2002-04-03 2005-09-09 주식회사 인섹트 바이오텍 A composition for washing foot
KR20160042294A (en) 2014-10-08 2016-04-19 이현기 Cosmetic Composition for removing keratin comprising cultures of novel microorganism separated from carnivorous plants

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