KR20000036770A - Development of Anthraban Material Using Bark of Haesong Pine - Google Patents
Development of Anthraban Material Using Bark of Haesong Pine Download PDFInfo
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- KR20000036770A KR20000036770A KR1020000015945A KR20000015945A KR20000036770A KR 20000036770 A KR20000036770 A KR 20000036770A KR 1020000015945 A KR1020000015945 A KR 1020000015945A KR 20000015945 A KR20000015945 A KR 20000015945A KR 20000036770 A KR20000036770 A KR 20000036770A
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- 239000000463 material Substances 0.000 title abstract description 8
- 235000008331 Pinus X rigitaeda Nutrition 0.000 title description 3
- 235000011613 Pinus brutia Nutrition 0.000 title description 3
- 241000018646 Pinus brutia Species 0.000 title description 3
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims 1
- 235000010204 pine bark Nutrition 0.000 claims 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract description 12
- 102000008186 Collagen Human genes 0.000 abstract description 8
- 108010035532 Collagen Proteins 0.000 abstract description 8
- 229920001436 collagen Polymers 0.000 abstract description 8
- 238000000034 method Methods 0.000 abstract description 7
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 abstract description 6
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 abstract description 6
- 235000005105 Pinus pinaster Nutrition 0.000 abstract description 5
- 241001236212 Pinus pinaster Species 0.000 abstract description 5
- 150000003254 radicals Chemical class 0.000 abstract description 5
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 abstract description 4
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 abstract description 4
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 abstract description 4
- 239000000843 powder Substances 0.000 abstract description 4
- 238000001914 filtration Methods 0.000 abstract description 3
- 239000002904 solvent Substances 0.000 abstract description 3
- 210000004204 blood vessel Anatomy 0.000 abstract description 2
- 230000006378 damage Effects 0.000 abstract description 2
- 238000000227 grinding Methods 0.000 abstract description 2
- 239000011780 sodium chloride Substances 0.000 abstract description 2
- 238000002211 ultraviolet spectrum Methods 0.000 abstract description 2
- 238000001291 vacuum drying Methods 0.000 abstract description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 2
- 230000004054 inflammatory process Effects 0.000 abstract 2
- 210000003491 skin Anatomy 0.000 abstract 2
- 201000004624 Dermatitis Diseases 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 208000028990 Skin injury Diseases 0.000 abstract 1
- 239000012620 biological material Substances 0.000 abstract 1
- 238000001035 drying Methods 0.000 abstract 1
- 229940093499 ethyl acetate Drugs 0.000 abstract 1
- 235000019439 ethyl acetate Nutrition 0.000 abstract 1
- 238000003306 harvesting Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000001473 noxious effect Effects 0.000 abstract 1
- 210000004927 skin cell Anatomy 0.000 abstract 1
- 230000000087 stabilizing effect Effects 0.000 abstract 1
- 230000003078 antioxidant effect Effects 0.000 description 6
- 230000008569 process Effects 0.000 description 6
- 239000002994 raw material Substances 0.000 description 6
- 230000009471 action Effects 0.000 description 5
- 239000003963 antioxidant agent Substances 0.000 description 5
- 235000006708 antioxidants Nutrition 0.000 description 5
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 206010028980 Neoplasm Diseases 0.000 description 3
- 230000032683 aging Effects 0.000 description 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 210000000987 immune system Anatomy 0.000 description 3
- 230000004060 metabolic process Effects 0.000 description 3
- 229910052760 oxygen Inorganic materials 0.000 description 3
- 239000001301 oxygen Substances 0.000 description 3
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 208000019622 heart disease Diseases 0.000 description 2
- 230000001926 lymphatic effect Effects 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 230000002792 vascular Effects 0.000 description 2
- 102000029816 Collagenase Human genes 0.000 description 1
- 108060005980 Collagenase Proteins 0.000 description 1
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
- 102000016942 Elastin Human genes 0.000 description 1
- 108010014258 Elastin Proteins 0.000 description 1
- 102000016387 Pancreatic elastase Human genes 0.000 description 1
- 108010067372 Pancreatic elastase Proteins 0.000 description 1
- 102000004142 Trypsin Human genes 0.000 description 1
- 108090000631 Trypsin Proteins 0.000 description 1
- 229930003268 Vitamin C Natural products 0.000 description 1
- 229930003427 Vitamin E Natural products 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 235000019606 astringent taste Nutrition 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 208000015669 capillary disease Diseases 0.000 description 1
- 230000004856 capillary permeability Effects 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 229960002424 collagenase Drugs 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 210000002808 connective tissue Anatomy 0.000 description 1
- 239000000539 dimer Substances 0.000 description 1
- 229920002549 elastin Polymers 0.000 description 1
- 230000001747 exhibiting effect Effects 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 210000002540 macrophage Anatomy 0.000 description 1
- 208000015122 neurodegenerative disease Diseases 0.000 description 1
- 239000000419 plant extract Substances 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 230000037394 skin elasticity Effects 0.000 description 1
- 230000035882 stress Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 239000013638 trimer Substances 0.000 description 1
- 239000012588 trypsin Substances 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/13—Coniferophyta (gymnosperms)
- A61K36/15—Pinaceae (Pine family), e.g. pine or cedar
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2200/00—Function of food ingredients
- A23V2200/02—Antioxidant
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/17—Preparation or pretreatment of starting material involving drying, e.g. sun-drying or wilting
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Botany (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Microbiology (AREA)
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- Biotechnology (AREA)
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Abstract
Description
본 발명의 목적은 우리의 신체가 활성산소(유해산소)로부터 공격을 받아 건강한 세포들이 손상을 입게 되고 퇴행성 질환을 초래하게 되는데, 이 활성산소는 우리 신체, 오염된 도시지역, 심한 운동, 식사, 스트레스에 노출된 사람들에게 만연하여 몸이 쇠약해져 노화가 촉진되고 질병에 걸리게 된다. 따라서 활성산소와 결합하는데 있어 안토플라반는 심장질환에 대항하여 보호하고, 기억력을 지속적으로 돕고, 일부 암의 위험도를 감소시키며 면역체계를 향상시키고 피부의 콜라겐을 안정시켜 피부의 탄력을 유지해주는 강력한 항산화제 소재를 개발하게 되었다.The object of the present invention is that our body is attacked by free radicals (harmful oxygen), which damages healthy cells and causes degenerative diseases. These free radicals are affected by our bodies, polluted urban areas, severe exercise, eating, It is prevalent in people exposed to stress, causing their bodies to weaken, which promotes aging and disease. Thus, in combination with free radicals, antoflavan is a powerful antioxidant that protects against heart disease, continues to help memory, reduces the risk of some cancers, improves the immune system, stabilizes the skin's collagen, and maintains skin's elasticity. I developed my material.
현대사회에서 생명공학분야는 신소재를 찾아내 우리 인체내 유익한 성분을 제공하여 신진대사를 촉진하고 나아가서는 각종 난치병을 예방하고 치유 치료할 수 있는 소재탐구에 집중연구개발하고 있다. 항산화제의 소재는 이미 여러 종 원료가 개발되어 사용되어지고 있으나, 대부분이 화학적 합성품이어서 이를 섭취하여도 체내에서 정상적으로 흡수되지 못하고 수용체가 거부함으로 큰 효과를 얻지 못하고 있다.In the modern society, the biotechnology sector is focusing on researching and developing new materials to provide beneficial ingredients in our human body to promote metabolism and further prevent and cure various incurable diseases. Antioxidant materials have already been developed and used in various kinds of raw materials, but most of them are chemical synthetics, so they are not normally absorbed by the body even if they are ingested, and the receptors are rejected.
본 발명은 강력한 항산화 효력을 발휘하는 천연 식물 추출물인 안토플라반 성분으로 세포와 조직 속에 있는 과도한 유해산소에 의해 유발되는 노화현상의 다양하고 해로운 특징들을 약화시켜주는 기능을 도와 신진대사를 촉진시켜 심장질환에 대항하여 보호하고, 기억력을 지속적으로 돕고, 일부 암의 위험도를 감소시키며 면역체계를 향상시키고 피부의 콜라겐을 안정시켜 피부의 생성 및 탄력을 유지해주는 강력한 항산화제 소재를 개발하게 되어 이를 이용한 산업적 응용분야를 확대해 나갈 것이다.The present invention is an antoflavan component, which is a natural plant extract exhibiting powerful antioxidant effects, helps to accelerate the metabolism by attenuating various and harmful features of aging caused by excessive harmful oxygen in cells and tissues. We have developed a powerful antioxidant that protects against diseases, continues to help memory, reduces the risk of some cancers, improves the immune system, stabilizes the collagen in the skin, and maintains skin's production and elasticity. We will expand our applications.
..
제 1공정(시료채취)First Step (Sample Collection)
Pinus Maritima, Pinus pinaster Solander 해안 소나무(해송) 껍질을 가공하기 위하여 소나무(20-30년생)를 채취한다.Pinus Maritima, Pinus pinaster Solander Pines (20-30 years old) are harvested for processing bark from coastal pines.
제 2공정(원 료)2nd process (raw material)
롤 커팅기를 이용하여 소나무의 껍질을 벗긴 다음 Dry-oven로 수분함량이 7%이하 되도록 50-60℃하에서 열풍 건조한다.Peel off the pine using a roll cutter, and then dry with hot air at 50-60 ℃ to dry-oven the moisture content below 7%.
제 3공정(분 쇄)Third process (grinding)
볼 믹서를 사용하여 건조된 원료를 분말화 한다. 여분의 원료는 비닐 팩에 넣어 건·냉한 곳에 보관한다.Powder the dried raw material using a ball mixer. Excess raw materials should be stored in a dry plastic bag in a dry plastic bag.
제 4공정(추 출)4th process (extraction)
분말화 된 원료를 96% 에탄올 용매(ethanol solution)를 가한 후 3회 이녹스 상태로 추출한다.The powdered raw material is extracted with inox state three times after adding 96% ethanol solution.
제 5공정(농 축)5th process (concentration)
진공농축기를 이용하여 추출된 용매를 증류한다. 이때 메탄올 용액(-20℃)을 이용한다.The extracted solvent is distilled off using a vacuum concentrator. In this case, a methanol solution (-20 ° C.) is used.
제 6공정(분 리)6th process (Separation)
진공을 이용하여 농축액을 물에 빨아들인 다음 분리한다.The concentrate is immersed in water using a vacuum and then separated.
제 7공정(여 과)7th process (filtration)
분리된 여액을 충분한 량의 염화나트륨 용액으로 3회 세척한다.The separated filtrate is washed three times with a sufficient amount of sodium chloride solution.
제 8공정 : 추 출8th Step: Extraction
수염액의 용액을 에틸아세테이드 용매를 사용하여 5회 추출한 다음 농축기를 이용하여 진공·농축한다. 농축된 용액을 에탄올 용액에 빨아들인 다음 순정 여과한다.The solution of the beard solution was extracted five times using ethyl acetate solvent, and then concentrated in vacuo using a concentrator. The concentrated solution is soaked in ethanol solution and then filtered pure.
제 9공정: 진공건조Step 9: vacuum drying
-20℃하에서 진공 건조된 것을 원료로 한다.Vacuum dried at -20 ° C as raw material.
일반적특징 : 밝은 황갈색의 분말로 떫은맛을 띄고 에탄올과 아세톤에 녹으며 벤젠과 클로로포름, 에테르에는 안 녹음, UV 스펙트럼에서 256±280㎚이다.GENERAL FEATURES: Light yellowish brown powder with astringent taste, soluble in ethanol and acetone, insoluble in benzene, chloroform and ether, 256 ± 280nm in UV spectrum.
본 발명은 첫째 강력한 항산화제 기능으로 모세혈관증, 세포와 조직 속에 있는 과도한 유해산소에 의해 유발되는 노화현상의 다양하고 해로운 특징들을 약화시켜주는 기능을 도와 신진대사를 촉진시켜며, 둘째 심장질환에 대항하여 보호하고, 기억력을 지속적으로 돕고, 일부 암의 위험도를 감소시키며 면역체계를 향상시키고, 세째 피부의 콜라겐을 안정시켜 피부의 탄력을 유지해주는 강력한 항산화제 소재로 산업적 응용분야에 기대효과가 크다. 이 안토플라반은 비타민 C 보다 20배나 비타민 E보다는 50배나 강력하고 효과적이다.The present invention is a powerful antioxidant function to promote metabolism by helping to attenuate various and harmful characteristics of aging caused by capillary disease, excessive harmful oxygen in the cells and tissues, and second to heart disease Strong anti-oxidant material that protects against, protects memory continuously, reduces the risk of some cancers, improves the immune system, and stabilizes the collagen of the third skin to maintain the elasticity of the skin. . This antoflavan is 20 times stronger than vitamin C and 50 times more potent and effective than vitamin E.
1. 화학적으로는 Falvan-3-ol의 구조의 축합물인 antoflavan dimer, trimer들이 혼재되어 있어 이들 antoflavan이라 부른다.1. Chemically, antoflavan dimers and trimers, which are condensates of Falvan-3-ol, are mixed. These are called antoflavan.
2. 약리학적으로2. Pharmacologically
가. 구조적 작용end. Structural action
1) 혈관벽 결합조직의 collagen과 elastin에 주로 결합하여 collagenase, elastase의 작 작용을 억제(혈관벽 결합조직의 섬유보호 효과)1) It mainly binds to collagen and elastin of vascular wall connective tissue and inhibits the action of collagenase and elastase.
2) Trypsin의 작용 억제, free radical 포획(혈관벽 구성물질 보호)2) Inhibition of Trypsin action, free radical capture (protection of vascular wall components)
3) Collagen의 cross-ink를 형성하기에 적당한 구조3) Structure suitable to form collagen cross-ink
4) 혈관벽내 cholesterol 축적억제(혈관벽 경화의 완화)4) Inhibiting the accumulation of cholesterol in the blood vessel wall (relieving vessel wall hardening)
5) Collagen의 전하를 변화시켜 polymerisation 촉진(collagen의 β-microfibril formation 촉진)5) Promote polymerisation by changing the charge of collagen (promoting β-microfibril formation of collagen)
6) Fibonectin와 ealstonectin의 량 증가(transformation이나 세포간 결합력 증진)6) Increased fibonectin and ealstonectin levels (transformation or intercellular binding)
나. 기능적 작용I. Functional action
1) 증가된 모세혈관 투과성을 억제1) inhibit increased capillary permeability
2) 정맥의 신축성을 강하게 회복2) strongly restore the elasticity of the veins
3) 림프순환 속도를 증가시켜 lymphatic drainage를 증가시키고 macrophage의 작용을 증대3) Increase lymphatic circulation rate to increase lymphatic drainage and increase macrophage action
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020000015945A KR20000036770A (en) | 2000-03-28 | 2000-03-28 | Development of Anthraban Material Using Bark of Haesong Pine |
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| Application Number | Priority Date | Filing Date | Title |
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| KR1020000015945A KR20000036770A (en) | 2000-03-28 | 2000-03-28 | Development of Anthraban Material Using Bark of Haesong Pine |
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| Publication Number | Publication Date |
|---|---|
| KR20000036770A true KR20000036770A (en) | 2000-07-05 |
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| Application Number | Title | Priority Date | Filing Date |
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| KR1020000015945A KR20000036770A (en) | 2000-03-28 | 2000-03-28 | Development of Anthraban Material Using Bark of Haesong Pine |
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| Country | Link |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006090953A1 (en) * | 2005-02-28 | 2006-08-31 | Nutrapharm Co. Ltd. | Extraction method for antioxidants from pine trees using natural solvents and antioxidant extracts thereby |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60174722A (en) * | 1984-02-21 | 1985-09-09 | Yasumasa Mimura | Preparation of remedy for dermatophytosis, etc. |
| KR930021110A (en) * | 1992-04-02 | 1993-11-22 | 하야시바라겡 | Method for improving palatability of pine extract and oral ingestion prepared by the method |
| KR960040209A (en) * | 1996-08-29 | 1996-12-17 | 이광묵 | Processing method of fruit drink and processing of livestock forage using pine needles |
| KR980000151A (en) * | 1996-06-20 | 1998-03-30 | 서정기 | Manufacturing method of health food based on pine bark |
| JPH1175708A (en) * | 1997-07-15 | 1999-03-23 | Kikkoman Corp | Protein food |
-
2000
- 2000-03-28 KR KR1020000015945A patent/KR20000036770A/en not_active Application Discontinuation
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60174722A (en) * | 1984-02-21 | 1985-09-09 | Yasumasa Mimura | Preparation of remedy for dermatophytosis, etc. |
| KR930021110A (en) * | 1992-04-02 | 1993-11-22 | 하야시바라겡 | Method for improving palatability of pine extract and oral ingestion prepared by the method |
| KR980000151A (en) * | 1996-06-20 | 1998-03-30 | 서정기 | Manufacturing method of health food based on pine bark |
| KR960040209A (en) * | 1996-08-29 | 1996-12-17 | 이광묵 | Processing method of fruit drink and processing of livestock forage using pine needles |
| JPH1175708A (en) * | 1997-07-15 | 1999-03-23 | Kikkoman Corp | Protein food |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006090953A1 (en) * | 2005-02-28 | 2006-08-31 | Nutrapharm Co. Ltd. | Extraction method for antioxidants from pine trees using natural solvents and antioxidant extracts thereby |
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