KR19990001380A - Blending Whitening Composition - Google Patents
Blending Whitening Composition Download PDFInfo
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- KR19990001380A KR19990001380A KR1019970024683A KR19970024683A KR19990001380A KR 19990001380 A KR19990001380 A KR 19990001380A KR 1019970024683 A KR1019970024683 A KR 1019970024683A KR 19970024683 A KR19970024683 A KR 19970024683A KR 19990001380 A KR19990001380 A KR 19990001380A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/981—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of mammals or bird
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
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Abstract
본 발명은 주성분으로 바다제비집으로부터 추출된 바다제비집추출물을 함유하며, 보조성분으로 알부틴 또는 코지산을 함유하는 것을 특징으로 하는 혼합 미백제조성물을 제공한다.The present invention provides a mixed whitening composition, which contains a bird's nest extract extracted from a bird's nest as a main component, and contains arbutin or kojic acid as an auxiliary component.
본 발명에 의한 미백제조성물은 종래의 알부틴이나 코지산을 단독으로 사용한 미백제조성물인 경우에 얻어지는 티로시나제 억제작용 및 그에 따른 멜라닌 색소형성 억제작용에 대한 미백효과에 비하여, 바다제비집추출물을 혼합사용함으로써 소량으로도 월등히 우수한 상승적 미백효과를 제공할 뿐 아니라, 제조과정중에 또는 제품의 보관중 있을 수 있는 경시 변화등의 문제를 극복하고 피부에 자극이 없는 효과가 있다.The whitening composition according to the present invention has a small amount by mixing and using the sea bird's nest extract as compared to the whitening effect on the tyrosinase inhibitory action and the melanin pigmentation inhibitory action obtained when the conventional whitening composition using arbutin or kojic acid alone. Not only does it provide an excellent synergistic whitening effect, but it also overcomes problems such as changes over time that may occur during the manufacturing process or during the storage of the product and has no skin irritation effect.
Description
본 발명은 혼합 미백제조성물에 관한 것으로, 더욱 구체적으로는 주성분으로 바다제집으로부터 추출된 바다제비집추출물을 함유하며, 보조성분으로 알부틴 또는 코지산을 함유하는 혼합 미백제조성물에 관한 것이다.The present invention relates to a mixed whitening composition, and more particularly, to a mixed whitening composition containing sea bird's nest extract extracted from sea collection as a main component, and containing arbutin or kojic acid as auxiliary components.
사람의 피부색은 주로 피부 세포속에 함유되어 있는 멜라닌을 함유하는 멜라노좀의 숫자, 크기, 종류 및 분포도에 따라 다르게 나타난다. 멜라노좀은 멜라닌세포에 의해 생성되며, 생성된 멜라닌은 과도한 자외선으로부터 피부를 보호함으로써 광선에 의한 피부 손상, 피부암의 발생을 억제하는 중요한 역할을 한다. 그러나 일광, 호르몬의 변화, 염증, 약제 등에 의해 유발된 멜라닌의 과다생성으로 인한 피부의 색소침착은 미용적인 측면에서 여러 가지 문제를 야기한다. 피부의 과색소 질환인 기미나 주근깨 등은 멜라닌의 양이 증가된 것으로 이는 멜라닌의 형성과정이 촉진되거나 멜라닌 세포의 수가 증가된 것에 기인한다.Human skin color depends mainly on the number, size, type and distribution of melanocytes containing melanin contained in skin cells. Melanosomes are produced by melanocytes, and the produced melanin plays an important role in preventing skin damage and skin cancer caused by light rays by protecting the skin from excessive ultraviolet rays. However, pigmentation of the skin due to overproduction of melanin caused by daylight, hormonal changes, inflammation, and drugs causes various problems in terms of beauty. Hyperpigmentation of the skin, such as blemishes and freckles, is due to an increase in the amount of melanin, which is due to the accelerated melanogenesis process or an increase in the number of melanocytes.
멜라닌 형성과정에서 가장 중요한 역할을 하는 것은 티로시나제(tyrosinase) 효소로 알려져 있는데, 이 효소는 조직중에 존재하는 티로신(tyrosine)이라고 하는 아미노산에 작용하는 도파퀴논(dopaquinone)을 생성시키며 이 도파퀴논으로부터 여러단계의 자동산화과정을 거쳐 멜라닌을 생성케 한다.The most important role in melanin formation is known as the tyrosinase enzyme, which produces dopaquinones that act on amino acids called tyrosine in the tissues, and from this dopaquinone It produces melanin through the automatic oxidation process.
따라서 티로시나제 효소의 활성을 억제시키면 멜라닌 생성을 억제할 수 있다는 점에 착안하여 종래 화장품 분야에서 미백성분으로써 히드로퀴논, 트레티오인, 코지산, 알부틴, 아스코르빈산, 글루타치온 등을 티로시나제 활성 저해물질로 이용하는 방법이 일부 이용되어 왔다. 그러나 상기한 성분들을 사용하여 화장품을 제조할 경우 제조과정중에 또는 제품의 보관중에 착색되는 단점이 있으며, 이러한 착색을 줄이기 위하여 다량의 첨가제를 사용하거나 유효성분을 소량으로 첨가하여야 하는데, 첨가제를 사용하는 경우에는 이러한 첨가제 성분에 의한 부작용이 발생할 수 있으므로 피부에 대한 안전성에 문제가 있고, 유효성분을 소량으로 사용하는 경우에는 목적하는 만큼의 충분한 미백효과를 얻을 수 없다는 단점이 있었다.In view of the fact that inhibiting the activity of tyrosinase enzymes can inhibit melanin production, hydroquinone, trethioin, kojic acid, arbutin, ascorbic acid, glutathione, etc. are used as tyrosinase inhibitors in whitening cosmetics. Some methods have been used. However, when manufacturing cosmetics using the above-mentioned ingredients, there is a disadvantage in that the coloration during the manufacturing process or the storage of the product, in order to reduce the coloration to use a large amount of additives or to add a small amount of the active ingredient, In this case, there may be a side effect caused by such additive components, so there is a problem in safety for the skin, and in the case of using an active ingredient in a small amount, there is a disadvantage in that sufficient whitening effects cannot be obtained as desired.
따라서 기존의 미백제보다 소량을 사용하면서도 탁월한 미백효과가 있고, 피부에 자극 등의 부작용이 없는 미백제의 개발이 필요하게 되었다.Therefore, while using a smaller amount than the existing whitening agent has excellent whitening effect, there is a need for the development of a whitening agent without side effects such as irritation to the skin.
본 발명자는 종래의 미백물질등이 갖는 문제점을 해결하고 보다 우수한 미백원료를 찾고자 자연의 여러 가지 천연물 중에서 과색소침작 예방에 유효한 물질들을 검색한 결과, 현재까지 화장품에 사용될 수 있는 미백원료들 중에서 바다제비집추출물이 티로시나제 저해물질로서 이용될 수 있음을 알게 되었다.The present inventors have searched for substances that are effective in preventing hyperpigmentation among various natural products of nature in order to solve the problems of the conventional whitening materials and to find more excellent whitening raw materials, among the whitening raw materials that can be used in cosmetics to date It has been found that the bird's nest extract can be used as a tyrosinase inhibitor.
또한 본 발명자는 기존의 미백성분과 바다제비집추출물을 배합하여 사용하는 경우 두 성분간의 미백상승효과로 인해 기존 미백성분들의 단점을 보완할 수 있을 뿐 아니라, 소량의 배합물으로도 목적하는 미백효과를 얻을 수 있음을 확인하고 본 발명을 완성하였다.In addition, the present inventors can compensate for the shortcomings of the existing whitening components due to the whitening synergy effect between the two components when using a combination of the existing whitening component and the bird's nest extract, and obtain the desired whitening effect even with a small amount of the formulation It was confirmed that the present invention was completed.
따라서 본 발명은 기존 미백제보다 소량을 사용하면서도 탁월한 미백효과를 가지며 피부 자극등의 부작용이 없는 화장료용 혼합 미백제조성물을 제공하는 것을 목적으로 한다.Accordingly, an object of the present invention is to provide a cosmetic whitening composition for cosmetics having a superior whitening effect and no side effects such as skin irritation while using a smaller amount than the existing whitening agent.
도 1A 는 바다제비집추출물과 알부틴의 배합농도 변화에 따른 티로시나제 활성저해율을 나타낸 그래프.1A is a graph showing the inhibition rate of tyrosinase activity according to the change in the concentration of algae extract and arbutin.
도 1B는 바다제비집추출물 또는 알부틴의 농도 변화에 따른 티로시나제 활성저해율을 나타낸 그래프.Figure 1B is a graph showing the inhibition rate of tyrosinase activity according to the concentration of sea bird's nest extract or arbutin.
도 2A는 바다제비집추출물과 코지산의 배합농도 변화에 따른 티로시나제 활성저해율을 나타낸 그래프.Figure 2A is a graph showing the inhibitory rate of tyrosinase activity according to the change in the concentration of seaweed extract and kojic acid.
도 2B는 바다제비집추출물 또는 코지산의 농도 변화에 따른 티로시나제 활성저해율을 나타낸 그래프.Figure 2B is a graph showing the inhibition rate of tyrosinase activity according to the concentration change of sea bird's nest extract or kojic acid.
본 발명은 주성분으로 바다제비집으로부터 추출된 바다제비집추출물을 함유하며, 보조성분으로 알부틴 또는 코지산을 함유하는 것을 특징으로 하는 혼합 미백제조성물을 제공한다.The present invention provides a mixed whitening composition, which contains a bird's nest extract extracted from a bird's nest as a main component, and contains arbutin or kojic acid as an auxiliary component.
본 발명에 사용된 바다제비집추출물을 제비가 바다에서 바다물질을 물어다 지은 제비집(birds' nest)으로부터 추출한 것으로서, 바다제비집은 원산지인 태국의 푸켓, 인도네시아 및 싱가폴 등지에서 이미 식용의 식품으로 시판되고 있고, 고대중국 황실에서 왕비나 귀족들이 얼굴과 몸의 피부를 아름답고 희게 만들기 위한 개선제로 사용해 왔던 것으로 알려져 있다.The bird's nest extract used in the present invention is extracted from the bird's nest (birds' nest) that swallowed the sea material in the sea, the bird's nest is already marketed as food for food in Thailand, Phuket, Indonesia and Singapore, etc. In the ancient Chinese imperial family, queens and aristocrats have been known to have been used as an adjuvant to make the skin of the face and body beautiful and white.
본 발명에 의한 미백제조성물은 유연화장수(스킨), 영양화장수(로션), 영양크림, 맛사지크림, 엣센스 또는 팩 등에 적용할 수 있다.The whitening composition according to the present invention can be applied to softening cream (skin), nutrient cream (lotion), nourishing cream, massage cream, essence or pack.
본 발명을 좀더 상세히 설명하면 다음과 같다.The present invention will be described in more detail as follows.
바다제비집추출물은 바다제비집으로부터 추출해내는 방법에 따라 액상(Liquid)타입과 젤(Gel)타입의 2가지가 있다.There are two kinds of sea bird's nest extract, liquid type and gel type according to the extraction method from sea bird's nest.
본 발명에서는 상용의 바다제비집추출물(캄포(CAMPO RESEARCH)사 제품)을 사용하였는데, 이 추출물은 비다제비집을 에탄올과 물과의 1:1 혼합액 속에 넣어, 고스팀증류화한 후 냉각시켜 젤(Gel)화 하고, 이것을 에탄올과 다시 1:2의 비율로 혼합하여 액상의 제형으로 만든 것이다.In the present invention, a commercial sea bird's nest extract (Campo RESEARCH Co., Ltd.) was used, and this extract was placed in a 1: 1 mixture of ethanol and water, cooled by distillation and steamed to gel (Gel). ), Which is then mixed with ethanol in a ratio of 1: 2 to form a liquid formulation.
본 발명에 사용된 바다제비집추출물의 구성성분으로는 다당류가 90%, L-아스코르빈산이 2%, 페놀라제가 1.5%, 폴리페놀옥시다제가 1.5%, 카테콜옥시다제가 1.5%, 페닐알라닌이 1%, L-티로신이 1.0%, 그 외 여러종류의 효소와 비타민 보조인자 및 젤라틴이 소량 포함되어 있다.As components of the bird's nest extract used in the present invention, polysaccharide is 90%, L-ascorbic acid 2%, phenolase 1.5%, polyphenol oxidase 1.5%, catecholoxidase 1.5%, phenylalanine It contains 1%, 1.0% of L-tyrosine and other small amounts of enzymes, vitamin cofactors and gelatin.
본 발명에 사용된 바다제비집추출물의 물성은 비중이 20℃에서 0.980이고, 굴절률이 20℃에서 1.475이고, 건조잔류물은 160℃에서 45%를 차지하며, 중금속(비소, 납, 수은 등을 포함한 전제량)의 함량은 0.05ppm 이하이다.The physical properties of the bird's nest extract used in the present invention has a specific gravity of 0.980 at 20 ℃, a refractive index of 1.475 at 20 ℃, dry residues account for 45% at 160 ℃, including heavy metals (arsenic, lead, mercury, etc.) Content) is 0.05 ppm or less.
본 발명에 의한 혼합 미백제조성물은 보조성분인 알부틴 또는 코지산과 주성분인 바다제비집추출몰과의 배합비가 중량%로 1:0.1∼10, 바람직하게는 1:1∼5 이다.In the mixed whitening composition according to the present invention, the compounding ratio of arbutin or kojic acid as an auxiliary component and sea bird's nest extraction mole as a main component is 1: 0.1 to 10, preferably 1: 1 to 5 in weight%.
상기한 바와 같은 배합비로 혼합된 알부틴 또는 코지산과 바다제비집추출물과의 배합물은 유연화장수(스킨), 영양화장수(로션), 영양크림, 맛사지크림, 엣센스 또는 팩 등에 첨가되어 제품화될 수 있는데, 각 체형의 총중량을 기준으로 하여 일반적으로 0.01∼10.0 중량%, 바람직하게는 0.1∼3.0 중량% 함유될 수 있다.The combination of arbutin or kojic acid and bird's nest extract mixed at the above-mentioned compounding ratio may be added to softened longevity (skin), nutritious longevity (lotion), nourishing cream, massage cream, essence or pack, etc., each body type It may generally contain 0.01 to 10.0% by weight, preferably 0.1 to 3.0% by weight based on the total weight of.
본 발명에 따르는 혼합 미백제조성물의 티로시나제 억제효과는 문헌에 기재된 방법, 예를 들면 메이슨(H.S. Mason) 및 나가스(T. Nagath)의 방법 [참고문헌: H.S. Mason, Biochem. Biophysics. Acta. 111, 134(1965); T. Nagath, Experimentia, 28(6), 634(1972)]을 이용하여 측정할 수 있다.The tyrosinase inhibitory effect of the mixed whitening composition according to the present invention is determined by methods described in the literature, such as those of H. S. Mason and T. Nagath. [Reference: H.S. Mason, Biochem. Biophysics. Acta. 111, 134 (1965); T. Nagath, Experimentia, 28 (6), 634 (1972)].
본 발명을 하기의 실시예를 들어 설명하지만, 이에 한정되는 것은 아니며, 본 발명의 사상과 범위내에서 다양한 실시예와 변화가 가능하다.The present invention will be described with reference to the following examples, but the present invention is not limited thereto, and various embodiments and changes can be made without departing from the spirit and scope of the present invention.
[실시예]EXAMPLE
조성물예 1: 영양크림Composition Example 1: Nourishing Cream
성 분함량(중량%)Content (% by weight)
바다제비집추출물2.0Bird's Nest Extract 2.0
알부틴1.0Arbutin 1.0
유동파라핀6.0Liquid paraffin 6.0
스쿠알란4.0Squalane 4.0
소르비탄세스퀴올레이트0.5Sorbitan Sesquioleate0.5
폴리솔베이트 601.5Polysorbate 601.5
밀납10.0Beeswax 10.0
카프필릭/카프릭트리글리세라이드5.0Capricic / Capric Triglycerides5.0
농글리세린6.0Concentrated glycerin6.0
프로필렌글리콜3.0Propylene Glycol 3.0
부틸렌글리콜2.0Butylene Glycol2.0
트리에탄올아민0.2Triethanolamine 0.2
방부제미량Preservative
색소미량A small amount of pigment
향료미량Trace amount
정제수잔액Purified water balance
상기의 성분들을 사용하여 화장품 제조분야의 통상의 방법에 따라 목적하는 영양크림제를 제조하였다.Using the above ingredients to prepare the desired nutrition cream according to the conventional method in the cosmetic manufacturing field.
조성물예 2: 영양화장수(로션)Composition Example 2: Nutrients (Lotion)
성 분함량(중량%)Content (% by weight)
바다제비집추출물1.0Bird's Nest Extract 1.0
알부틴1.0Arbutin 1.0
세탄올1.0Cetanol1.0
스테아릴알콜1.0Stearyl Alcohol 1.0
글리세린 모노스테아레이트3.0Glycerin Monostearate 3.0
소르비탄 모노스테아레이트1.0Sorbitan Monostearate 1.0
폴리옥시에틸렌소르비탄 모노올리에이트2.0Polyoxyethylene sorbitan monooleate 2.0
바셀린2.0Vaseline 2.0
유동파라핀6.0Liquid paraffin 6.0
스쿠알란5.0Squalane 5.0
옥틸도데실 미리스테이트5.0Octyldodecyl Myristate 5.0
글리세린5.0Glycerin5.0
1,3-부틸렌글리콜5.01,3-butylene glycol 5.0
카르복시비닐폴리머0.3Carboxy Vinyl Polymer 0.3
트리에탄올아민0.3Triethanolamine0.3
방부제미량Preservative
색소미량A small amount of pigment
향료미량Trace amount
정제수잔액Purified water balance
상기의 성분들을 사용하여 화장품 제조분야의 통상의 방법에 따라 목적하는 영양화장수를 제조하였다.Using the above ingredients to prepare the desired nutrient cosmetics according to a conventional method in the cosmetic manufacturing field.
조성물예 3: 유연화장수(스킨)Composition Example 3: Softening Longevity (Skin)
성 분함량(중량%)Content (% by weight)
바다제비집추출물1.0Bird's Nest Extract 1.0
코지산1.0Kojisan1.0
농글리세린2.0Concentrated glycerin2.0
프로필렌글리콜3.0Propylene Glycol 3.0
부틸렌글리콜2.0Butylene Glycol2.0
에탄올10.0Ethanol 10.0
카르복시비닐폴리머0.1Carboxy Vinyl Polymer 0.1
트리에탄올아민0.1Triethanolamine 0.1
방부제미량Preservative
색소미량A small amount of pigment
향료미량Trace amount
정제수잔액Purified water balance
상기의 성분들을 사용하여 화장품 제조분야의 통상의 방법에 따라 목적하는 유연화장수를 제조하였다.Using the above ingredients to prepare the desired softening cosmetics according to the conventional method in the cosmetic manufacturing field.
조성물예 4: 에센스Composition Example 4: Essence
성 분함량(중량%)Content (% by weight)
바다제비집추출물3.0Bird's Nest Extract 3.0
코지산1.0Kojisan1.0
프로필렌글리콜5.0Propylene Glycol5.0
글리세린10.0Glycerin10.0
1,3-부틸렌글리콜10.01,3-butylene glycol 10.0
폴리에틸렌글리콜 15005.0Polyethylene Glycol 15005.0
카르복시비닐폴리머0.5Carboxy Vinyl Polymer0.5
히드록시에틸셀룰로오스0.5Hydroxyethyl Cellulose0.5
트리에탄올아민0.5Triethanolamine0.5
에탄올5.0Ethanol 5.0
폴리옥시에틸렌노닐페닐에테르0.7Polyoxyethylene Nonylphenyl Ether 0.7
방부제미량Preservative
색소미량A small amount of pigment
향료미량Trace amount
정제수잔액Purified water balance
상기의 성분들을 사용하여 화장품 제조분야의 통상의 방법에 따라 목적하는 에센스를 제조하였다.The above ingredients were used to prepare the desired essence according to conventional methods in the field of cosmetic manufacture.
조성물예 5: 맛사지크림Composition Example 5: Massage Cream
성 분함량(중량%)Content (% by weight)
바다제비집추출물0.5Bird's Nest Extract0.5
알부틴0.5Arbutin0.5
유동파라핀40.0Liquid paraffin 40.0
수크알란5.0Souk Alan 5.0
소르비탄세스퀴올레이트0.8Sorbitan Sesquioleate 0.8
폴리솔베이트 601.5Polysorbate 601.5
밀납10.0Beeswax 10.0
카프필릭/카프릭트리글리세라이드4.0Capric & Capric Triglycerides 4.0
농글리세린6.0Concentrated glycerin6.0
프로필렌글리콜2.0Propylene Glycol2.0
부틸렌글리콜4.0Butylene Glycol4.0
트리에탄올아민0.2Triethanolamine 0.2
방부제미량Preservative
색소미량A small amount of pigment
향료미량Trace amount
정제수잔액Purified water balance
상기의 성분들을 사용하여 화장품 제조분야의 통상의 방법에 따라 목적하는 맛사지크림을 제조하였다.Using the above ingredients to prepare the desired massage cream according to a conventional method in the cosmetic manufacturing field.
조성물예 6: 팩Composition Example 6: Pack
성 분함량(중량%)Content (% by weight)
바다제비집추출물0.5Bird's Nest Extract0.5
알부틴1.0Arbutin 1.0
알란토인0.2Allantoin0.2
에탄올5.0Ethanol 5.0
노닐페닐에테르0.3Nonylphenyl Ether0.3
나트륨카르복시메틸셀룰로오스0.2Sodium Carboxymethyl Cellulose0.2
폴리비닐알코올13.0Polyvinyl Alcohol 13.0
방부제미량Preservative
색소미량A small amount of pigment
향료미량Trace amount
정제수잔액Purified water balance
상기의 성분들을 사용하여 화장품 제조분야의 통상의 방법에 따라 목적하는 팩을 제조하였다.Using the above ingredients, the desired pack was prepared according to a conventional method in the cosmetic manufacturing field.
성능평가시험Performance Evaluation Test
1 : 바다제비집추출물과 알부틴과의 배합물의 티로시나제에 대한 억제효과1: Inhibitory Effect of Combination of Swallowweed Extract and Arbutin on Tyrosinase
본 발명의 혼합 미백제조성물의 티로시나제 활성억제 실험은 메이슨(H.S. Mason) 및 나가스(T. Nagath)의 방법에 따라 시행하였다. 시험 미백제로서 제1군은 알부틴의 농도를 0.03%로 고정시키고 바다제비집추출물의 농도를 0, 0.01, 0.03, 0.1 및 0.3%로 변화시킨 배합조성물을 사용하고, 제2군은 바다제비집추출물의 농도를 0.03%로 고정시키고 알부틴의 농도를 0, 0.01, 0.03, 0.1 및 0.3%로 변화시킨 배합조성물을 사용하였다. 또 제3군은 바다제비집추출물만을 0, 0.01, 0.03, 0.1 및 1.0%의 농도로 변화시켜 사용하고, 제4군은 알부틴만을 0, 0.01, 0.03, 0.1 및 1.0%의 농도로 변화시켜 사용하였다. 상기의 각 조성물을 1㎖씩 채취하여 샘플로 하였다. 상기 준비된 각각의 미백제 샘플에 티로시나제용액(티로시나제(3400유니트/고체 ㎎) 5㎎을 1/15M인산염 완충용액 10㎖에 용해시킨 용액) 0.1㎖ 및 1/15M 인산염 완충용액(pH 6.8) 0.9㎖를 가하고, 이 혼합물을 37℃에서 10분 동안 예열한 다음, 0.03% L-DOPA(L-3,4-디하이드록시페닐알라닌)용액 1㎖를 가하여 37℃에서 10분 동안 반응시켰다. 이 때 대조군은 각 미백제샘플 대신 1/15M 인산염 완충용액(pH 6.8) 1㎖를 가한다. 반응후, 흡수분광계(UVT06856, MOLECULAR DEVICE사의 MICROPLATE READER)를 사용하여 470nm에서 반응혼합물의 흡광도를 측정하였다. 각 미백제샘플의 티로시나제 활성저해율은 다음의 공식으로 구하였다.Tyrosinase activity inhibition experiment of the mixed whitening composition of the present invention was carried out according to the method of Mason (H.S. Mason) and Nagath (T. Nagath). As the test whitening agent, the first group used a combination composition in which the concentration of arbutin was fixed at 0.03% and the concentration of sea bird's nest extract was changed to 0, 0.01, 0.03, 0.1 and 0.3%, and the second group was the concentration of sea bird's nest extract. Was fixed at 0.03% and the concentration of arbutin was changed to 0, 0.01, 0.03, 0.1 and 0.3%. In addition, the third group used only the sea bird's nest extract at concentrations of 0, 0.01, 0.03, 0.1 and 1.0%, and the fourth group used only arbutin at a concentration of 0, 0.01, 0.03, 0.1 and 1.0%. . 1 ml of each said composition was extract | collected, and it was set as the sample. To each of the prepared whitening agent samples, 0.1 ml of tyrosinase solution (5 mg of tyrosinase (3400 units / solid mg) dissolved in 10 ml of 1/15 M phosphate buffer solution) and 0.9 ml of 1/15 M phosphate buffer (pH 6.8) were added. The mixture was preheated at 37 ° C. for 10 minutes, and then 1 ml of 0.03% L-DOPA (L-3,4-dihydroxyphenylalanine) solution was added and reacted at 37 ° C. for 10 minutes. At this time, the control group was added 1 ml of 1 / 15M phosphate buffer (pH 6.8) instead of each whitening agent sample. After the reaction, the absorbance of the reaction mixture was measured at 470 nm using an absorption spectrometer (UVT06856, MICROPLATE READER from MOLECULAR DEVICE). The tyrosinase activity inhibition rate of each whitening sample was calculated by the following formula.
그 결과를 하기의 표 1 및 표 2에 나타낸다.The results are shown in Tables 1 and 2 below.
[표 1]TABLE 1
바다제비집추출물과 알부틴과의 배합농도에 따른 티로시나제 억제활성Tyrosinase Inhibitory Activity According to the Concentration of Sea Swallow Extract and Arbutin
주) 상기의 수치는 평균±표준편차로 나타낸 것이다.Note) The above figures are expressed as mean ± standard deviation.
[표 2]TABLE 2
바다제비집추출물 또는 알부틴의 농도에 따른 티로시나제 억제활성Tyrosinase Inhibitory Activity According to the Concentration of Sea Swallow Extract or Arbutin
주) 상기의 수치는 평균±표준편차로 나타낸 것이다.Note) The above figures are expressed as mean ± standard deviation.
도 1A는 알부틴의 농도를 0.03%로 고정시키고 바다제비집추출물의 농도를 0 내지 0.3%로 변화시킨 제1군 및 바다제비집추출물의 농도를 0.03%로 고정시키고 알부틴의 농도를 0 내지 0.3%로 변화시킨 제2군의 티로시나제 활성저해율을 그래프로 나타낸 것이다. 또한, 도 1B는 바다제비집추출물만을 0 내지 1.0% 농도로 변화시킨 제3군 및 알부틴만을 0 내지 1.0% 농도로 변화시킨 제4군의 티로시나제 활성저해율을 그래프로 나타낸 것이다.1A shows that the concentration of arbutin was fixed at 0.03% and the concentration of seabird's nest extract was 0-0.3%, and the concentration of arthropod extract was fixed at 0.03% and the concentration of arbutin was changed to 0-0.3%. The tyrosinase activity inhibition rate of the second group was shown in a graph. In addition, FIG. 1B is a graph showing the tyrosinase activity inhibition rate of the third group in which only the seabird extract was changed to 0 to 1.0% concentration and the fourth group in which only arbutin was changed to 0 to 1.0% concentration.
상기 도 1A 및 도 1B에 도시된 바와 같이, 알부틴과 바다제비집추출물의 배합물을 사용한 제1군 및 제2군의 티로시나제 억제효과가 바다제비집추출물이나 알부틴을 단독으로 사용한 제3군 및 제4군의 티로시나제 억제효과 보다 크다는 것을 알 수 있다. 또한 단일 성분을 과량 사용하는 경우(예를 들어, 제3군 또는 제4군에서 농도가 1.0%인 경우)의 효과와 2가지 성분을 소량 혼합한 경우(예를 들어, 제1군 또는 제2군에서의 혼합농도가 0.13∼0.33%인 경우)의 효과를 비교한 결과, 양자의 효과가 거의 비슷하다는 것을 알 수 있다. 따라서 본 발명에 따른 알부틴을 혼합한 미백제조성물을 소량 사용하더라도 티로시나제 억제효과가 우수하다는 것을 알 수 있다.As shown in FIGS. 1A and 1B, the tyrosinase inhibitory effect of the first group and the second group using the combination of arbutin and the bird's nest extract is the third group and the fourth group using the bird's nest extract or arbutin alone. It can be seen that it is greater than the tyrosinase inhibitory effect. In addition, the effect of using an excessive amount of a single component (for example, when the concentration is 1.0% in the third or fourth group) and a small mixture of the two components (for example, the first group or the second group) As a result of comparing the effects of the mixed concentration in the group (0.13 to 0.33%), the effects of both are almost similar. Therefore, it can be seen that the tyrosinase inhibitory effect is excellent even when a small amount of the whitening composition mixed with arbutin according to the present invention is used.
2 : 바다제비집추출물과 코지산과의 배합물의 티로시나제에 대한 억제효과2: Inhibitory Effect of Combination of Swallowweed Extract and Kojic Acid on Tyrosinase
알부틴 대신에 코지산을 사용한 것외에는 성능평가시험 1과 동일하게 시행하였다. 즉, 시험 미백제로서 제1군은 코지산의 농도를 0.03%로 고정시키고 바다제비집추출물의 농도를 0, 0.01, 0.03, 0.1 및 0.3%로 변화시킨 배합조성물을 사용하고, 제2군은 바다제비집추출물의 농도를 0.03%로 고정시키고 코지산의 농도를 0, 0.01, 0.03, 0.1 및 0.3%로 변화시킨 배합조성물을 사용하였다. 또 제3군은 바다제비집추출물만을 0, 0.01, 0.03, 0.1 및 1.0%의 농도로 변화시켜 사용하고, 제4군은 알부틴만을 0, 0.01, 0.03, 0.1 및 1.0%의 농도로 변화시켜 사용하였다.Except for using kojic acid in place of arbutin was carried out in the same manner as in the performance evaluation test 1. That is, as the test whitening agent, the first group uses a combination composition in which the concentration of kojic acid is fixed at 0.03% and the concentration of sea bird extract is changed to 0, 0.01, 0.03, 0.1 and 0.3%, and the second group is the bird's nest. A combination composition was used in which the concentration of the extract was fixed at 0.03% and the concentration of kojic acid was changed to 0, 0.01, 0.03, 0.1 and 0.3%. In addition, the third group used only the sea bird's nest extract at concentrations of 0, 0.01, 0.03, 0.1 and 1.0%, and the fourth group used only arbutin at a concentration of 0, 0.01, 0.03, 0.1 and 1.0%. .
그 결과를 하기의 표 3 및 4에 나타낸다.The results are shown in Tables 3 and 4 below.
[표 3]TABLE 3
바다제비집추출물과 코지산과의 배합농도에 따른 티로시나제 억제활성Tyrosinase Inhibitory Activity According to the Concentration of Sea Swallow Extract and Koji Acid
주) 상기의 수치는 평균±표준편차로 나타낸 것이다.Note) The above figures are expressed as mean ± standard deviation.
[표 4]TABLE 4
바다제비집추출물 또는 코지산의 농도에 따른 티로시나제 억제활성Tyrosinase Inhibitory Activity According to Concentration of Sea Swallow Extract or Kojic Acid
주) 상기의 수치는 평균±표준편차로 나타낸 것이다.Note) The above figures are expressed as mean ± standard deviation.
도 2A에서는 코지산의 농도를 0.03%로 고정시키고, 바다제비집추출물의 농도를 0 내지 0.3%로 변화시킨 제1군 및 바다제비집추출물의 농도를 0.03%로 고정시키고, 코지산의 농도를 0 내지 0.3%로 변화시킨 제2군의 티로시나제 활성저해율을 그래프로 나타낸 것이다. 또한, 도 2B에는 바다제비집추출물만을 0 내지 1.0% 농도로 변화시킨 제3군 및 코지산만을 0 내지 1.0 농도로 변화시킨 제4군의 티로시나제 활성저해율을 그래프로 나타낸 것이다.In FIG. 2A, the concentration of kojic acid is fixed at 0.03%, the concentration of the first group and the bird's nest extract is changed to 0.03%, and the concentration of kojic acid is 0 to 0.3%. The tyrosinase activity inhibition rate of the second group changed to 0.3% is shown graphically. In addition, in FIG. 2B, the tyrosinase activity inhibition rate of the third group in which only the seaweed collection extract was changed to 0 to 1.0% concentration and the fourth group in which only koji acid was changed to 0 to 1.0 concentration is shown in a graph.
상기 도 2A 및 도 2B에 도시된 바와 같이, 코지산과 바다제비집추출물의 배합물을 사용한 제1군 및 제2군의 티로시나제 억제효과가 바다제비집추출물이나 코지산을 단독으로 사용한 제3군 및 제4군의 티로시나제 억제효과 보다 크다는 것을 알 수 있다. 또한 단일 성분을 과량 사용하는 경우(예를 들어, 제3군 또는 제4군에서 농도가 1.0%인 경우)의 효과와 2가지 성분을 소량 혼합한 경우(예를 들어, 제1군 또는 제2군에서의 혼합농도가 0.13∼0.33%인 경우)의 효과를 비교한 결과, 양자의 효과가 거의 비슷하다는 것을 알 수 있다. 따라서 본 발명에 따른 코지산을 혼합한 미백제조성물을 소량 사용하더라도 티로시나제 억제효과가 우수하다는 것을 알 수 있다.As shown in FIG. 2A and FIG. 2B, the tyrosinase inhibitory effect of the first group and the second group using the combination of kojic acid and the bird's nest extract is the third group and the fourth group using the bird's nest extract or koji acid alone. It can be seen that the greater than the tyrosinase inhibitory effect of. In addition, the effect of using an excessive amount of a single component (for example, when the concentration is 1.0% in the third or fourth group) and a small mixture of the two components (for example, the first group or the second group) As a result of comparing the effects of the mixed concentration in the group (0.13 to 0.33%), the effects of both are almost similar. Therefore, it can be seen that the tyrosinase inhibitory effect is excellent even when a small amount of the whitening composition mixed with kojic acid according to the present invention is used.
이상 성능평가시험 결과에서도 알 수 있는 바와 같이, 본 발명의 혼합 미백제조성물은 종래의 알부틴 또는 코지산을 단독으로 사용한 경우에 얻어지는 티로시나제 억제작용 및 그에 따른 멜라닌 색소형성 억제작용에 대한 미백효과에 비하여, 미백효과가 우수하고 소량을 사용하더라도 우수한 미백효과를 얻을 수 있다.As can be seen from the results of the above performance evaluation test, the mixed whitening composition of the present invention is compared with the whitening effect on tyrosinase inhibitory action and melanin pigmentation inhibitory action obtained when the conventional arbutin or kojic acid is used alone, Excellent whitening effect and excellent whitening effect can be obtained even in small amount.
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| KR1019970024683A KR100447441B1 (en) | 1997-06-13 | 1997-06-13 | Skin whitening agent containing bird's nest extract as tyrosinase inhibiting agent as main component and albutin or kojic acid as auxiliary component |
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| KR1019970024683A KR100447441B1 (en) | 1997-06-13 | 1997-06-13 | Skin whitening agent containing bird's nest extract as tyrosinase inhibiting agent as main component and albutin or kojic acid as auxiliary component |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20010086190A (en) * | 2000-02-11 | 2001-09-10 | 이영준 | Skin Whitening Composition with Gymnema Extract |
| KR100424728B1 (en) * | 2001-05-28 | 2004-03-30 | 주식회사 바이오랜드 | Whitening and wrinkle improvement cosmetics composition containing Areca catechu extract and Arbutin |
| KR100666889B1 (en) * | 1999-06-09 | 2007-01-10 | 가부시키가이샤 구라레 | Polyvinyl alcohol polymer production and polyvinyl alcohol polymer |
| KR100810589B1 (en) * | 2000-06-02 | 2008-03-06 | 펜타팜아게 | Topical agent for dermatological use containing 4-hydroxyphenyl-alpha-d-glucopyranoside |
| KR100894528B1 (en) * | 2001-09-27 | 2009-04-22 | 콤비 가부시키가이샤 | Skin care agent |
| KR101418825B1 (en) * | 2013-07-02 | 2014-07-16 | 건국대학교 산학협력단 | Composition for Reducing Skin Irritation Comprising Fermented Extract from Swallow's Nest and Centella asiatica As Active Ingredient |
| KR20180107334A (en) * | 2017-03-16 | 2018-10-02 | 디랑(주) | Compositions for improving dry skin comprising swiftlet´s nest extract and fucoidan |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2718018B1 (en) * | 1994-04-05 | 1996-04-26 | Oreal | Cosmetic and / or dermatological composition with hydrophilic support and vitamin C mixable extemporaneously. |
| KR0147412B1 (en) * | 1994-06-03 | 1998-08-17 | 한동근 | Whitening cosmetics containing purified morus marus cortex, fructus extract and kojic acid |
| KR100202058B1 (en) * | 1995-04-07 | 1999-06-15 | 이병훈 | Mixed whitening compositions |
| KR0163514B1 (en) * | 1995-12-02 | 1998-12-01 | 성재갑 | Cosmetic composition for whitening |
| KR970032824A (en) * | 1995-12-21 | 1997-07-22 | 이능희 | Whitening cosmetic composition containing kojic acid with improved stability and no skin irritation |
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1997
- 1997-06-13 KR KR1019970024683A patent/KR100447441B1/en not_active IP Right Cessation
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100666889B1 (en) * | 1999-06-09 | 2007-01-10 | 가부시키가이샤 구라레 | Polyvinyl alcohol polymer production and polyvinyl alcohol polymer |
| KR20010086190A (en) * | 2000-02-11 | 2001-09-10 | 이영준 | Skin Whitening Composition with Gymnema Extract |
| KR100810589B1 (en) * | 2000-06-02 | 2008-03-06 | 펜타팜아게 | Topical agent for dermatological use containing 4-hydroxyphenyl-alpha-d-glucopyranoside |
| KR100424728B1 (en) * | 2001-05-28 | 2004-03-30 | 주식회사 바이오랜드 | Whitening and wrinkle improvement cosmetics composition containing Areca catechu extract and Arbutin |
| KR100894528B1 (en) * | 2001-09-27 | 2009-04-22 | 콤비 가부시키가이샤 | Skin care agent |
| KR101418825B1 (en) * | 2013-07-02 | 2014-07-16 | 건국대학교 산학협력단 | Composition for Reducing Skin Irritation Comprising Fermented Extract from Swallow's Nest and Centella asiatica As Active Ingredient |
| KR20180107334A (en) * | 2017-03-16 | 2018-10-02 | 디랑(주) | Compositions for improving dry skin comprising swiftlet´s nest extract and fucoidan |
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