KR102666564B1 - Mouthwash composition with excellent effect of improving gum disease by containing topan salt - Google Patents
Mouthwash composition with excellent effect of improving gum disease by containing topan salt Download PDFInfo
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- KR102666564B1 KR102666564B1 KR1020230067501A KR20230067501A KR102666564B1 KR 102666564 B1 KR102666564 B1 KR 102666564B1 KR 1020230067501 A KR1020230067501 A KR 1020230067501A KR 20230067501 A KR20230067501 A KR 20230067501A KR 102666564 B1 KR102666564 B1 KR 102666564B1
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- South Korea
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- parts
- salt
- gum disease
- oral
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- 239000000203 mixture Substances 0.000 title claims abstract description 54
- 208000024693 gingival disease Diseases 0.000 title claims abstract description 50
- 150000003839 salts Chemical class 0.000 title claims abstract description 43
- 230000000694 effects Effects 0.000 title abstract description 60
- 229940051866 mouthwash Drugs 0.000 title description 2
- 239000002324 mouth wash Substances 0.000 title 1
- 239000003112 inhibitor Substances 0.000 claims abstract description 29
- 241000411851 herbal medicine Species 0.000 claims abstract description 21
- 239000008213 purified water Substances 0.000 claims abstract description 20
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 20
- 239000000654 additive Substances 0.000 claims abstract description 18
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 claims abstract description 14
- 229960003260 chlorhexidine Drugs 0.000 claims abstract description 14
- KSQXVLVXUFHGJQ-UHFFFAOYSA-N sodium;2-phenylphenol Chemical class [Na+].OC1=CC=CC=C1C1=CC=CC=C1 KSQXVLVXUFHGJQ-UHFFFAOYSA-N 0.000 claims abstract description 14
- 239000000284 extract Substances 0.000 claims abstract description 13
- 230000019612 pigmentation Effects 0.000 claims description 16
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 claims description 14
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 claims description 13
- 239000011737 fluorine Substances 0.000 claims description 13
- 229910052731 fluorine Inorganic materials 0.000 claims description 13
- 235000021096 natural sweeteners Nutrition 0.000 claims description 11
- 239000013535 sea water Substances 0.000 claims description 11
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 10
- 230000000996 additive effect Effects 0.000 claims description 10
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 8
- -1 chlorohydroxyaluminum Chemical compound 0.000 claims description 7
- 239000011775 sodium fluoride Substances 0.000 claims description 7
- 235000013024 sodium fluoride Nutrition 0.000 claims description 7
- BFDWBSRJQZPEEB-UHFFFAOYSA-L sodium fluorophosphate Chemical compound [Na+].[Na+].[O-]P([O-])(F)=O BFDWBSRJQZPEEB-UHFFFAOYSA-L 0.000 claims description 7
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- GNPVGFCGXDBREM-UHFFFAOYSA-N germanium atom Chemical compound [Ge] GNPVGFCGXDBREM-UHFFFAOYSA-N 0.000 claims description 6
- 239000012676 herbal extract Substances 0.000 claims description 6
- YASYEJJMZJALEJ-UHFFFAOYSA-N Citric acid monohydrate Chemical compound O.OC(=O)CC(O)(C(O)=O)CC(O)=O YASYEJJMZJALEJ-UHFFFAOYSA-N 0.000 claims description 5
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 5
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 5
- 235000011187 glycerol Nutrition 0.000 claims description 5
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- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims description 4
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- XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 claims description 4
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- 235000010323 ascorbic acid Nutrition 0.000 claims description 4
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- WBZKQQHYRPRKNJ-UHFFFAOYSA-L disulfite Chemical compound [O-]S(=O)S([O-])(=O)=O WBZKQQHYRPRKNJ-UHFFFAOYSA-L 0.000 claims description 4
- 238000001704 evaporation Methods 0.000 claims description 4
- FTSSQIKWUOOEGC-RULYVFMPSA-N fructooligosaccharide Chemical compound OC[C@H]1O[C@@](CO)(OC[C@@]2(OC[C@@]3(OC[C@@]4(OC[C@@]5(OC[C@@]6(OC[C@@]7(OC[C@@]8(OC[C@@]9(OC[C@@]%10(OC[C@@]%11(O[C@H]%12O[C@H](CO)[C@@H](O)[C@H](O)[C@H]%12O)O[C@H](CO)[C@@H](O)[C@@H]%11O)O[C@H](CO)[C@@H](O)[C@@H]%10O)O[C@H](CO)[C@@H](O)[C@@H]9O)O[C@H](CO)[C@@H](O)[C@@H]8O)O[C@H](CO)[C@@H](O)[C@@H]7O)O[C@H](CO)[C@@H](O)[C@@H]6O)O[C@H](CO)[C@@H](O)[C@@H]5O)O[C@H](CO)[C@@H](O)[C@@H]4O)O[C@H](CO)[C@@H](O)[C@@H]3O)O[C@H](CO)[C@@H](O)[C@@H]2O)[C@@H](O)[C@@H]1O FTSSQIKWUOOEGC-RULYVFMPSA-N 0.000 claims description 4
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- FSYKKLYZXJSNPZ-UHFFFAOYSA-N sarcosine Chemical compound C[NH2+]CC([O-])=O FSYKKLYZXJSNPZ-UHFFFAOYSA-N 0.000 claims description 4
- 238000005507 spraying Methods 0.000 claims description 4
- 239000001585 thymus vulgaris Substances 0.000 claims description 4
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- 235000001050 hortel pimenta Nutrition 0.000 claims description 3
- 244000088415 Raphanus sativus Species 0.000 claims description 2
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- 240000001949 Taraxacum officinale Species 0.000 claims description 2
- 235000005187 Taraxacum officinale ssp. officinale Nutrition 0.000 claims description 2
- 241000207965 Acanthaceae Species 0.000 claims 1
- 238000009835 boiling Methods 0.000 claims 1
- 230000006872 improvement Effects 0.000 abstract description 28
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- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/20—Halogens; Compounds thereof
- A61K8/21—Fluorides; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/23—Sulfur; Selenium; Tellurium; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/43—Guanidines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
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- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
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- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/817—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen; Compositions or derivatives of such polymers, e.g. vinylimidazol, vinylcaprolactame, allylamines (Polyquaternium 6)
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
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- A—HUMAN NECESSITIES
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
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- A—HUMAN NECESSITIES
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- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
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Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Inorganic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cosmetics (AREA)
Abstract
본 발명은 토판염이 함유되어 잇몸질환 개선 효과가 우수한 구강세정용 조성물에 관한 것으로, 더욱 상세하게는 정제수 100 중량부, 토판염 1 내지 3 중량부, 클로로헥시딘 0.1 내지 0.3 중량부, 색소침착억제제 0.1 내지 0.5 중량부, 한약재 추출물 0.5 내지 1 중량부 및 첨가제 1 내지 3 중량부로 이루어진다.
상기의 성분으로 이루어지는 구강세정용 조성물은 토판염이 함유되어 우수한 잇몸질환 개선 효과를 나타낼 뿐만 아니라, 우수한 기호도를 나타내면서도 충치억제 및 구취제거 효과를 나타낸다.The present invention relates to an oral cleansing composition that contains topan salt and is excellent in improving gum disease. More specifically, it relates to an oral cleaning composition containing 100 parts by weight of purified water, 1 to 3 parts by weight of topan salt, 0.1 to 0.3 parts by weight of chlorhexidine, and pigment. It consists of 0.1 to 0.5 parts by weight of a deposition inhibitor, 0.5 to 1 part by weight of herbal medicine extract, and 1 to 3 parts by weight of additives.
The oral cleansing composition composed of the above ingredients not only exhibits an excellent gum disease improvement effect by containing topane salt, but also exhibits excellent palatability while exhibiting effects of suppressing cavities and removing bad breath.
Description
본 발명은 토판염이 함유되어 잇몸질환 개선 효과가 우수한 구강세정용 조성물에 관한 것으로, 더욱 상세하게는 토판염이 함유되어 우수한 잇몸질환 개선 효과를 나타낼 뿐만 아니라, 우수한 기호도를 나타내면서도 충치억제 및 구취제거 효과를 나타내는 토판염이 함유되어 잇몸질환 개선 효과가 우수한 구강세정용 조성물에 관한 것이다.The present invention relates to an oral cleansing composition containing topan salt, which has an excellent gum disease improvement effect. More specifically, it contains topan salt, which not only has an excellent gum disease ameliorating effect, but also exhibits excellent acceptability while suppressing cavities and bad breath. The present invention relates to an oral cleansing composition that is excellent in improving gum disease as it contains tophanate, which has a removal effect.
구강질환 중 하나인 잇몸질환은 외래 다빈도 질환 중에서 3위를 차지하고 있으며, 발병률이 높고 매년 증가추세를 나타내고 있다.Gum disease, one of the oral diseases, ranks third among the most common outpatient diseases, and its incidence rate is high and increasing every year.
또한 구강질환은 전신만성질환 발생과 밀접한 관련이 있으며, 의료 및 치의약 분야 관련 건강보조식품과 위생용품 개발시, 친환경 및 인체친화적 천연소재의 중요성은 날로 증대되고 있으며, 특히, 전신만성질환 발생과 밀접한 관련이 있는 구강질환 예방과 개선을 위한 구강보건용품 소재에서 천연추출물에 대한 관심이 증가하고 있다.In addition, oral diseases are closely related to the occurrence of systemic chronic diseases, and the importance of eco-friendly and human-friendly natural materials is increasing day by day when developing health supplements and hygiene products related to the medical and dental fields. In particular, the occurrence of systemic chronic diseases is increasing. There is increasing interest in natural extracts as materials for oral health products to prevent and improve closely related oral diseases.
국내 성인의 80%, 그리고 실버세대 연령의 90%가 만성적으로 구강질환에 시달리고 있으나 사전에 예방차원에서 관리할 수 있는 보조제품의 개발 및 상용화는 미미한 실정이다.80% of domestic adults and 90% of the silver generation chronically suffer from oral diseases, but the development and commercialization of supplementary products that can manage preventive diseases in advance is minimal.
한편, 종래에 판매중인 기능성 구강 세정제의 경우, 프라그 저해, 구강내 유해균 억제, 구취개선 및 미백효과 등의 기능성을 내세워 판매가 되고 있으나 연령별 및 개인의 구강체질별 특성을 감안하지 않은 제품들이 대다수이며, 대부분이 화학물질로 이루어져 체질에 따라서는 잇몸질환과 구내염증을 오히려 악화시키는 경우가 빈번하게 발생하고 있어 이를 대체할 제품품의 개발이 요구되고 있다.Meanwhile, in the case of conventionally sold functional oral cleaners, they are sold with functionality such as plaque inhibition, inhibition of harmful bacteria in the oral cavity, improvement of bad breath, and whitening effect, but most of the products do not take into account the characteristics of each age and individual's oral constitution. Most of them are made of chemicals, and depending on the constitution, they often worsen gum disease and oral inflammation, so there is a need for the development of products to replace them.
본 발명의 목적은 토판염이 함유되어 우수한 잇몸질환 개선 효과를 나타낼 뿐만 아니라, 우수한 기호도를 나타내면서도 충치억제 및 구취제거 효과를 나타내는 토판염이 함유되어 잇몸질환 개선 효과가 우수한 구강세정용 조성물을 제공하는 것이다.The purpose of the present invention is to provide an oral cleansing composition that not only has excellent gum disease improvement effects by containing topane salts, but also has an excellent gum disease improvement effect by containing tophan salts, which exhibits excellent palatability and has anti-cavity and bad breath removal effects. It is done.
본 발명의 목적은 정제수 100 중량부, 토판염 1 내지 3 중량부, 클로로헥시딘 0.1 내지 0.3 중량부, 색소침착억제제 0.1 내지 0.5 중량부, 한약재 추출물 0.5 내지 1 중량부 및 첨가제 1 내지 3 중량부로 이루어지며, 상기 색소침착억제제는 메타중아황산염, 아스코르브산, 히알루론산 및 폴리비닐피롤리돈비닐아세테이트가 1:1:1:1의 중량부로 혼합되어 이루어지고, 상기 한약재 추출물은 정제수 100 중량부에 덖음된 한약재 5 내지 20 중량부를 혼합하고 80 내지 90℃의 온도로 3 내지 5시간 동안 가열하여 제조되며, 상기 덖음된 한약재는 목단피, 백지, 세신, 박하, 백리향, 해열목, 가시오가피, 버드나무, 무환자, 산골취 및 개똥쑥으로 이루어진 그룹에서 선택된 하나 이상으로 이루어지고, 상기 첨가제는 D-소르비톨액, 식물성 글리세린, 코코베타인, 구연산 수화물 및 천연감미료로 이루어지는 것을 특징으로 하는 토판염이 함유되어 잇몸질환 개선 효과가 우수한 구강세정용 조성물을 제공함에 의해 달성된다.The purpose of the present invention is to use 100 parts by weight of purified water, 1 to 3 parts by weight of topane salt, 0.1 to 0.3 parts by weight of chlorhexidine, 0.1 to 0.5 parts by weight of pigmentation inhibitor, 0.5 to 1 part by weight of herbal medicine extract, and 1 to 3 parts by weight of additives. The pigmentation inhibitor is composed of metabisulfite, ascorbic acid, hyaluronic acid, and polyvinylpyrrolidone vinyl acetate mixed in a ratio of 1:1:1:1 by weight, and the herbal medicine extract is 100 parts by weight of purified water. It is prepared by mixing 5 to 20 parts by weight of the boiled herbal medicine and heating it at a temperature of 80 to 90 ° C. for 3 to 5 hours, and the boiled herbal medicine includes dandelion bark, white paper, sesame seeds, mint, thyme, parsley tree, acanthophylla, and willow. , it is composed of one or more selected from the group consisting of sorghum, sorghum, and artemisia, and the additives contain tophan salt, which is composed of D-sorbitol solution, vegetable glycerin, cocobetaine, citric acid hydrate, and natural sweetener. This is achieved by providing an oral cleaning composition with excellent gum disease improvement effects.
본 발명의 바람직한 특징에 따르면, 상기 토판염은 염전에 200 내지 300 메쉬의 천연 게르마늄 분말을 살포한 후에, 염전 바닥을 10 내지 20 센티미터의 깊이로 갈아 토판을 형성하고, 상기 토판이 형성된 염전에 염도가 23 내지 25%로 농축된 해수를 투입한 후에 해수를 증발시키는 과정으로 제조되는 것으로 한다.According to a preferred feature of the present invention, the topan salt is prepared by spraying natural germanium powder of 200 to 300 mesh in the salt pan, then plowing the bottom of the salt pan to a depth of 10 to 20 centimeters to form a toppan, and adding salt to the salt pan where the top plate is formed. It is manufactured by adding seawater concentrated to 23 to 25% and then evaporating the seawater.
본 발명의 더 바람직한 특징에 따르면, 상기 토판염이 함유되어 잇몸질환 개선 효과가 우수한 구강세정용 조성물에는 상기 정제수 100 중량부 대비 불소성분 0.01 내지 0.05 중량부 및 잇몸질환 억제제 0.01 내지 0.5 중량부가 더 함유되며, 상기 불소성분은 불화나트륨 및 불소인산나트륨으로 이루어진 그룹에서 선택된 하나 이상으로 이루어지고, 상기 잇몸질환 억제제는 알란토인클로로히드록시알루미늄으로 이루어지는 것으로 한다.According to a more preferred feature of the present invention, the oral cleansing composition containing the topan salt and having an excellent gum disease improvement effect further contains 0.01 to 0.05 parts by weight of a fluorine component and 0.01 to 0.5 parts by weight of a gum disease inhibitor based on 100 parts by weight of the purified water. The fluorine component is composed of one or more selected from the group consisting of sodium fluoride and sodium fluorophosphate, and the gum disease inhibitor is composed of allantoin chlorohydroxyaluminum.
본 발명의 더욱 바람직한 특징에 따르면, 상기 덖음은 70 내지 80℃의 온도에서 20 내지 40분 동안 이루어지는 것으로 한다.According to a more preferred feature of the present invention, the roasting is performed at a temperature of 70 to 80° C. for 20 to 40 minutes.
본 발명의 더욱 더 바람직한 특징에 따르면, 상기 천연감미료는 프락토올리고당, 자일로스, 결정과당, 스테비아, 자일리톨, 에리스리톨 및 알루로스로 이루어진 그룹에서 선택된 하나 이상으로 이루어지는 것으로 한다.According to an even more preferred feature of the present invention, the natural sweetener is composed of one or more selected from the group consisting of fructooligosaccharide, xylose, crystalline fructose, stevia, xylitol, erythritol, and allulose.
본 발명에 따른 토판염이 함유되어 잇몸질환 개선 효과가 우수한 구강세정용 조성물은 토판염이 함유되어 우수한 잇몸질환 개선 효과를 나타낼 뿐만 아니라, 우수한 기호도를 나타내면서도 충치억제 및 구취제거 효과를 나타내는 구강세정용 조성물을 제공하는 탁월한 효과를 나타낸다.The oral cleansing composition containing topan salt according to the present invention, which has an excellent gum disease improvement effect, not only contains topan salt and exhibits an excellent gum disease improvement effect, but also exhibits excellent acceptability and is an oral rinse that exhibits cavity suppression and bad breath removal effects. The composition provides excellent effectiveness.
이하에는, 본 발명의 바람직한 실시예와 각 성분의 물성을 상세하게 설명하되, 이는 본 발명이 속하는 기술분야에서 통상의 지식을 가진 자가 발명을 용이하게 실시할 수 있을 정도로 상세하게 설명하기 위한 것이지, 이로 인해 본 발명의 기술적인 사상 및 범주가 한정되는 것을 의미하지는 않는다.Below, preferred embodiments of the present invention and the physical properties of each component are described in detail, but the purpose is to provide a detailed description so that a person skilled in the art can easily carry out the invention. This does not mean that the technical idea and scope of the present invention are limited.
본 발명에 따른 토판염이 함유되어 잇몸질환 개선 효과가 우수한 구강세정용 조성물은 정제수, 토판염, 클로로헥시딘, 색소침착억제제, 한약재 추출물 및 첨가제로 이루어지며, 정제수 100 중량부, 토판염 1 내지 3 중량부, 클로로헥시딘 0.1 내지 0.3 중량부, 색소침착억제제 0.1 내지 0.5 중량부, 한약재 추출물 0.5 내지 1 중량부 및 첨가제 1 내지 3 중량부로 이루어지는 것이 바람직하다.The oral cleaning composition containing topane salt according to the present invention and having excellent gum disease improvement effect consists of purified water, tophan salt, chlorhexidine, anti-pigmentation agent, herbal medicine extract and additives, 100 parts by weight of purified water, 1 part by weight of tophan salt. It is preferably composed of 0.1 to 3 parts by weight of chlorhexidine, 0.1 to 0.3 parts by weight of pigmentation inhibitor, 0.1 to 0.5 parts by weight of herbal medicine extract, and 1 to 3 parts by weight of additives.
상기 토판염(土版鹽)은 1 내지 3 중량부가 함유되며, 염전에 200 내지 300 메쉬의 천연 게르마늄 분말을 살포한 후에, 염전 바닥을 10 내지 20 센티미터의 깊이로 갈아 토판을 형성하고, 상기 토판이 형성된 염전에 염도가 23 내지 25%로 농축된 해수를 투입한 후에 해수를 증발시키는 과정으로 제조되는데, 이때, 상기 게르마늄의 살포량은 해수 1톤당 0.1 내지 1g으로 이루어지는 것이 바람직하다.The earthen salt contains 1 to 3 parts by weight, and after spraying natural germanium powder of 200 to 300 mesh in the salt pan, the bottom of the salt pan is ground to a depth of 10 to 20 centimeters to form a earthen plate, and the earthen plate is formed. It is manufactured by adding seawater concentrated to a salinity of 23 to 25% into the formed salt pond and then evaporating the seawater. At this time, the spray amount of germanium is preferably 0.1 to 1 g per ton of seawater.
상기의 과정을 통해 제조되는 토판염은 바닷물에 포함된 미네랄 외에 갯벌에 포함된 미네랄, 아미노산 및 유기화합물 등이 함께 염에 포함되게 되므로 미네랄과 영양성분이 풍부하게 함유되어 있으며, 이들 성분이 강한 짠맛을 내는 염화나트륨을 감싸고 있어 독특한 향을 나타내며 부드럽고 단맛을 나타내어 기호도를 향상시키는 작용을 한다.Topan salt manufactured through the above process is rich in minerals and nutrients, as it includes minerals, amino acids, and organic compounds contained in tidal flats in addition to the minerals contained in seawater, and these elements give it a strong salty taste. It contains sodium chloride, which gives it a unique aroma and a soft, sweet taste that improves preference.
또한, 상기의 토판염은 소염, 항균 및 해독효능이 우수하여 치아 미백, 구강내 청결, 충치예방 및 구치제거 효과를 나타낼 뿐만 아니라, 치은염, 치주염, 치주질환, 치태제거 및 잇몸질환을 예방효과를 나타낸다.In addition, the above-mentioned topan salt has excellent anti-inflammatory, antibacterial and detoxifying effects, and not only has the effect of whitening teeth, cleaning the oral cavity, preventing cavities and removing molar teeth, but also has preventive effects on gingivitis, periodontitis, periodontal disease, plaque removal and gum disease. indicates.
상기 토판염의 함량이 1 중량부 미만이면 상기의 효과가 미미하며, 상기 토판염의 함량이 3 중량부를 초과하게 되면 상기의 효과는 크게 향상되지 않으면서 제조비용을 지나치게 증가시키기 때문에 바람직하지 못하다.If the content of the topane salt is less than 1 part by weight, the effect is minimal, and if the content of the topane salt exceeds 3 parts by weight, the effect is not significantly improved and the manufacturing cost is excessively increased, which is undesirable.
상기 클로로헥시딘은 0.1 내지 0.3 중량부가 함유되며, 안티플라크 (antiplaque) 및 항균 활성을 부여하는 역할을 하는데, 칼슘 이온과 이의 길항적인 메커니즘(competitive mechanism)에 의해 매트릭스에 작용하여 치아 표면에 이미 침착된 층을 분해할 수 있고, 새로운 플라크의 형성을 억제하는 역할을 한다.The chlorhexidine contains 0.1 to 0.3 parts by weight and plays a role in imparting antiplaque and antibacterial activity. It acts on the matrix by calcium ions and its competitive mechanism to form a substance already on the tooth surface. It can break down the deposited layer and plays a role in suppressing the formation of new plaque.
상기 클로로헥시딘의 함량이 0.1 중량부 미만이면 상기의 효과가 미미하며, 상기 클로로헥시딘의 함량이 0.3 중량부를 초과하게 되면 상기의 효과는 크게 향상되지 않으면서 치아의 표면이 착생되는 현상이 발생할 수 있기 때문에 바람직하지 못하다.If the content of chlorhexidine is less than 0.1 part by weight, the above effect is minimal, and if the content of chlorhexidine exceeds 0.3 part by weight, the above effect is not significantly improved and the phenomenon of growth on the surface of the tooth This is not desirable because this may occur.
상기 색소침착억제제는 0.1 내지 0.5 중량부가 함유되며, 메타중아황산염, 아스코르브산, 히알루론산 및 폴리비닐피롤리돈비닐아세테이트가 1:1:1:1의 중량부로 혼합되어 이루어지는데, 상기 클로로헥시딘 등의 사용으로 인해 치아가 색소침착되는 것을 억제하는 역할을 한다.The pigmentation inhibitor contains 0.1 to 0.5 parts by weight, and is made by mixing metabisulfite, ascorbic acid, hyaluronic acid, and polyvinylpyrrolidone vinyl acetate at a weight ratio of 1:1:1:1, and the chlorohexyl It plays a role in suppressing pigmentation of teeth caused by the use of products such as Dean.
상기 색소침착억제제의 함량이 0.1 중량부 미만이면 상기의 효과가 미미하며, 상기 색소침착억제제의 함량이 0.5 중량부를 초과하게 되면 상기의 효과는 크게 향상되지 않으면서 구강세정용 조성물의 구강세정 효과가 저하되고, 제조비용이 지나치게 증가되기 때문에 바람직하지 못하다.If the content of the pigmentation inhibitor is less than 0.1 part by weight, the effect is minimal, and if the content of the pigmentation inhibitor exceeds 0.5 parts by weight, the effect is not significantly improved and the oral cleansing effect of the oral cleansing composition is reduced. This is undesirable because it decreases and the manufacturing cost increases excessively.
상기 한약재 추출물은 0.5 내지 1 중량부가 함유되며, 정제수 100 중량부에 덖음된 한약재 5 내지 20 중량부를 혼합하고 80 내지 90℃의 온도로 3 내지 5시간 동안 가열하여 제조되는데, 이때, 상기 한약재는 잇몸질환을 개선 및 예방하는 효능을 나타내는 한약재로 이루어지는 것이 바람직하며, 목단피, 백지, 세신, 박하, 백리향, 해열목, 가시오가피, 버드나무, 무환자, 산골취 및 개똥쑥으로 이루어진 그룹에서 선택된 하나 이상으로 이루어지는 것이 더욱 바람직하다.The herbal medicine extract contains 0.5 to 1 part by weight, and is prepared by mixing 5 to 20 parts by weight of the herbal medicine mixed with 100 parts by weight of purified water and heating at a temperature of 80 to 90 ° C. for 3 to 5 hours. At this time, the herbal medicine is applied to the gums. It is preferable that it is made of a herbal medicine that shows the efficacy of improving and preventing diseases, and is made of one or more selected from the group consisting of Mokdan bark, Baekji, Seshin, peppermint, thyme, antipyretic tree, Acanthophyllum, willow, achyranthes, mountain golchwi, and artemisia. It is more desirable.
또한 상기 덖음은 70 내지 80℃의 온도에서 20 내지 40분 동안 이루어지는데, 상기의 온도와 시간 동안 덖음된 한약재로 제조되는 한약재 추출물은 유효성분의 용출효과가 월등하게 향상되어 잇몸질환 개선효과가 더욱 향상된 구강세정용 조성물을 제조할 수 있다.In addition, the roasting is performed at a temperature of 70 to 80°C for 20 to 40 minutes, and the herbal medicine extract prepared from the herbal medicine roasted at the above temperature and time significantly improves the dissolution effect of the active ingredients, further improving gum disease. An improved composition for oral cleaning can be prepared.
상기 한약재 추출물의 함량이 0.5 중량부 미만이면 상기의 효과가 미미하며, 상기 한약재 추출물의 함량이 1 중량부를 초과하게 되면 상기의 효과는 크게 향상되지 않으면서 구강세정용 조성물의 향과 전체적인 기호도가 저하될 수 있기 때문에 바람직하지 못하다.If the content of the herbal medicine extract is less than 0.5 parts by weight, the effect is minimal, and if the content of the herbal medicine extract exceeds 1 part by weight, the effect is not significantly improved, and the scent and overall preference of the oral cleansing composition are reduced. It is undesirable because it can happen.
상기 첨가제는 1 내지 3 중량부가 함유되며, D-소르비톨액, 식물성 글리세린, 코코베타인, 구연산 수화물 및 천연감미료로 이루어지며, D-소르비톨액 100 중량부, 식물성 글리세린 4 내지 6 중량부, 코코베타인 5 내지 20 중량부, 구연산 수화물 0.005 내지 0.015 중량부 및 천연감미료 0.5 내지 2 중량부로 이루어지는 것이 바람직한데, 본 발명을 통해 제조되는 구강세정용 조성물의 기호도 및 제형안정성을 향상시킬 뿐만 아니라 균일한 물성을 나타내는 구강세정용 조성물이 제공될 수 있도록 하는 역할을 한다.The additive contains 1 to 3 parts by weight and consists of D-sorbitol solution, vegetable glycerin, coco betaine, citric acid hydrate and natural sweetener, 100 parts by weight of D-sorbitol solution, 4 to 6 parts by weight of vegetable glycerin, Coco Beta. It is preferably composed of 5 to 20 parts by weight of phosphorus, 0.005 to 0.015 parts by weight of citric acid hydrate, and 0.5 to 2 parts by weight of natural sweetener. This not only improves the palatability and formulation stability of the oral cleansing composition prepared through the present invention, but also provides uniform physical properties. It serves to provide a composition for oral cleaning that represents.
이때, 상기 천연감미료는 프락토올리고당, 자일로스, 결정과당, 스테비아, 자일리톨, 에리스리톨 및 알루로스로 이루어진 그룹에서 선택된 하나 이상으로 이루어지는데, 상기의 성분으로 이루어지는 천연감미료는 당의 함량이 낮으면서도 우수한 단맛을 나타내기 때문에 구강세정용 조성물의 기호도를 향상시키면서도 치아나 잇몸건강을 저하시키지 않는 효과를 나타내는데, 상기 천연감미료의 함량이 0.5 중량부 미만이면 상기의 효과가 미미하며, 상기 천연감미료의 함량이 2 중량부를 초과하게 되면 상기의 효과는 크게 향상되지 않으면서 구강세정용 조성물의 단맛이 지나치게 증가하기 때문에 바람직하지 못하다.At this time, the natural sweetener is composed of one or more selected from the group consisting of fructo-oligosaccharide, xylose, crystalline fructose, stevia, xylitol, erythritol, and allulose. The natural sweetener composed of the above components has a low sugar content but has excellent sweetness. Because it represents an effect that improves the preference of the oral cleansing composition while not deteriorating the health of teeth or gums, the effect is minimal if the content of the natural sweetener is less than 0.5 parts by weight, and the content of the natural sweetener is 2. If it exceeds the weight part, the above effect is not significantly improved and the sweetness of the oral cleansing composition is excessively increased, which is undesirable.
상기 첨가제의 함량이 1 중량부 미만이면 상기의 효과가 미미하며, 상기 첨가제의 함량이 3 중량부를 초과하게 되면 상기의 효과는 크게 향상되지 않으면서 구강세정용 조성물의 잇몸질환 개선 효과가 저하되기 때문에 바람직하지 못하다.If the content of the additive is less than 1 part by weight, the effect is minimal, and if the content of the additive exceeds 3 parts by weight, the effect is not significantly improved and the gum disease improvement effect of the oral cleansing composition is reduced. It is not desirable.
또한, 본 발명에 따른 토판염이 함유되어 잇몸질환 개선 효과가 우수한 구강세정용 조성물에는 상기 정제수 100 중량부 대비 불소성분 0.01 내지 0.05 중량부 및 잇몸질환 억제제 0.01 내지 0.5 중량부가 더 함유될 수도 있다.In addition, the composition for oral cleaning containing topan salt according to the present invention and having an excellent gum disease improvement effect may further contain 0.01 to 0.05 parts by weight of a fluorine component and 0.01 to 0.5 parts by weight of a gum disease inhibitor based on 100 parts by weight of the purified water.
상기 불소성분은 불화나트륨 및 불소인산나트륨으로 이루어진 그룹에서 선택된 하나 이상으로 이루어지는데, 상기와 같이 불화나트륨 및 불소인산나트륨 등이 더 함유되면 충치억제 효과가 부여되는데, 상기 불소성분의 함량이 0.01 중량부 미만이면 상기의 효과가 미미하며, 상기 불소성분의 함량이 0.05 중량부를 초과하게 되면 상기의 효과는 크게 향상되지 않으면서 불소성분이 지나치게 과량 첨가되는 것으로 바람직하지 못하다.The fluorine component consists of one or more selected from the group consisting of sodium fluoride and sodium fluorophosphate. If sodium fluoride and sodium fluorophosphate are further contained as described above, a cavity inhibition effect is provided, and the content of the fluorine component is 0.01 weight. If the content is less than 0.05 parts by weight, the above effect is minimal, and if the content of the fluorine component exceeds 0.05 parts by weight, the above effect is not significantly improved and the fluorine component is added in excessive amounts, which is undesirable.
또한, 상기 잇몸질환 억제제는 알란토인클로로히드록시알루미늄으로 이루어지는 것이 바람직한데, 상기의 성분으로 이루어지는 잇몸질환 억제제는 잇몸질환 억제효과를 부여할 뿐만 아니라, 새로운 잇몸이 돋아나도록 유도하며 염증, 붓기 및 통증을 감소시키는 역할을 하는데, 상기 잇몸질환 억제제의 함량이 0.01 중량부 미만이면 상기의 효과가 미미하며, 상기 잇몸질환 억제제의 함량이 0.5 중량부를 초과하게 되면 상기의 효과는 크게 향상되지 않으면서 구강세정용 조성물의 제조비용을 지나치게 증가시키고 제형안정성을 저하시킬 수 있기 때문에 바람직하지 못하다.In addition, the gum disease inhibitor is preferably made of allantoin chlorohydroxyaluminum. The gum disease inhibitor made of the above ingredient not only provides a gum disease inhibitory effect, but also induces new gums to sprout and reduces inflammation, swelling and pain. It serves to reduce the effect. If the content of the gum disease inhibitor is less than 0.01 part by weight, the effect is minimal, and if the content of the gum disease inhibitor exceeds 0.5 part by weight, the effect is not significantly improved and is used for oral cleaning. This is undesirable because it may excessively increase the manufacturing cost of the composition and reduce formulation stability.
이하에서는, 본 발명에 따른 토판염이 함유되어 잇몸질환 개선 효과가 우수한 구강세정용 조성물의 제조방법 및 그 제조방법으로 제조된 구강세정용 조성물의 물성을 실시예를 들어 설명하기로 한다.Hereinafter, a method for producing an oral cleansing composition containing topane salt according to the present invention and having an excellent gum disease improvement effect and the physical properties of an oral cleansing composition prepared by the method will be described by way of examples.
<제조예 1> 토판염의 제조<Preparation Example 1> Preparation of topane salt
염전에 200 내지 300 메쉬의 천연 게르마늄 분말을 살포한 후에, 염전 바닥을 10 내지 20 센티미터의 깊이로 갈아 토판을 형성하고, 상기 토판이 형성된 염전에 염도가 24%로 농축된 해수를 투입하되, 해수 1 톤당 게르마늄 분말 0.1 내지 1g이 살포되는 조건으로 해수를 투입한 후에 해수를 증발시키는 과정을 통해 토판염을 제조하였다.After spraying natural germanium powder of 200 to 300 mesh into the salt pond, the bottom of the salt pan is ground to a depth of 10 to 20 centimeters to form a soil plate, and seawater concentrated to a salinity of 24% is added to the salt farm where the soil plate is formed. Topan salt was prepared through a process of evaporating the seawater after adding seawater under the condition that 0.1 to 1 g of germanium powder per ton was sprayed.
<제조예 2> 색소침착억제제의 제조<Preparation Example 2> Preparation of pigmentation inhibitor
메타중아황산염, 아스코르브산, 히알루론산 및 폴리비닐피롤리돈비닐아세테이트가 1:1:1:1의 중량부로 혼합하여 색소침착억제제를 제조하였다.A pigmentation inhibitor was prepared by mixing metabisulfite, ascorbic acid, hyaluronic acid, and polyvinylpyrrolidone vinyl acetate in a weight ratio of 1:1:1:1.
<제조예 3> 한약재 추출물의 제조<Preparation Example 3> Preparation of herbal medicine extract
정제수 100 중량부에 한약재(목단피, 백지, 세신, 박하, 백리향, 해열목, 가시오가피, 버드나무, 무환자, 산골취 및 개똥쑥을 동일한 중량부로 혼합하여 이루어진 혼합물을 75℃의 온도로 30분 동안 덖음하여 제조) 12 중량부를 혼합하고 85℃의 온도로 4시간 동안 가열한 후에 고형분을 제거하여 한약재 추출물을 제조하였다.A mixture of 100 parts by weight of purified water mixed with equal parts by weight of herbal medicine (skin bark, white paper, sesame seeds, peppermint, thyme, antipyretic tree, acanthus acanthus, willow, radish root, mountain snail, and artemisia) was boiled at a temperature of 75°C for 30 minutes. 12 parts by weight were mixed and heated at a temperature of 85°C for 4 hours, and the solid content was removed to prepare an herbal medicine extract.
<제조예 4> 첨가제의 제조<Preparation Example 4> Preparation of additives
D-소르비톨액 100 중량부, 식물성 글리세린 5 중량부, 코코베타인 12 중량부, 구연산 수화물 0.01 중량부 및 천연감미료(프락토올리고당 100 중량부에 스테비아 10 중량부가 혼합) 1.25 중량부를 혼합하여 첨가제를 제조하였다.Add additives by mixing 100 parts by weight of D-sorbitol solution, 5 parts by weight of vegetable glycerin, 12 parts by weight of coco betaine, 0.01 parts by weight of citric acid hydrate, and 1.25 parts by weight of natural sweetener (100 parts by weight of fructooligosaccharide mixed with 10 parts by weight of stevia). Manufactured.
<실시예 1><Example 1>
정제수 100 중량부, 상기 제조예 1을 통해 제조된 토판염 2 중량부, 클로로헥시딘 0.2 중량부, 상기 제조예 2를 통해 제조된 색소침착억제제 0.3 중량부, 상기 제조예 3을 통해 제조된 한약재 추출물 0.8 중량부 및 상기 제조예 4를 통해 제조된 첨가제 1.5 중량부를 혼합하여 토판염이 함유되어 잇몸질환 개선 효과가 우수한 구강세정용 조성물을 제조하였다.100 parts by weight of purified water, 2 parts by weight of topane salt prepared through Preparation Example 1, 0.2 parts by weight of chlorhexidine, 0.3 parts by weight of pigmentation inhibitor prepared through Preparation Example 2, and Preparation Example 3. 0.8 parts by weight of the herbal extract and 1.5 parts by weight of the additive prepared in Preparation Example 4 were mixed to prepare an oral cleaning composition containing topan salt and having an excellent gum disease improvement effect.
<실시예 2><Example 2>
정제수 100 중량부, 상기 제조예 1을 통해 제조된 토판염 1 중량부, 클로로헥시딘 0.1 중량부, 상기 제조예 2를 통해 제조된 색소침착억제제 0.1 중량부, 상기 제조예 3을 통해 제조된 한약재 추출물 0.5 중량부 및 상기 제조예 4를 통해 제조된 첨가제 1 중량부를 혼합하여 토판염이 함유되어 잇몸질환 개선 효과가 우수한 구강세정용 조성물을 제조하였다.100 parts by weight of purified water, 1 part by weight of topane salt prepared through Preparation Example 1, 0.1 part by weight of chlorhexidine, 0.1 part by weight of pigmentation inhibitor prepared through Preparation Example 2, and Preparation Example 3. 0.5 parts by weight of the herbal extract and 1 part by weight of the additive prepared in Preparation Example 4 were mixed to prepare an oral cleansing composition containing topan salt and having an excellent gum disease improvement effect.
<실시예 3><Example 3>
정제수 100 중량부, 상기 제조예 1을 통해 제조된 토판염 3 중량부, 클로로헥시딘 0.3 중량부, 상기 제조예 2를 통해 제조된 색소침착억제제 0.5 중량부, 상기 제조예 3을 통해 제조된 한약재 추출물 1 중량부 및 상기 제조예 4를 통해 제조된 첨가제 3 중량부를 혼합하여 토판염이 함유되어 잇몸질환 개선 효과가 우수한 구강세정용 조성물을 제조하였다.100 parts by weight of purified water, 3 parts by weight of topane salt prepared through Preparation Example 1, 0.3 parts by weight of chlorhexidine, 0.5 parts by weight of pigmentation inhibitor prepared through Preparation Example 2, 1 part by weight of the herbal extract and 3 parts by weight of the additive prepared in Preparation Example 4 were mixed to prepare an oral cleaning composition containing topan salt and having an excellent gum disease improvement effect.
<실시예 4><Example 4>
상기 실시예 1과 동일하게 진행하되, 상기 정제수 100 중량부 대비 불소성분(불화나트륨 및 불소인산나트륨이 1:1의 중량부로 혼합) 0.03 중량부 및 잇몸질환 억제제(알란토인클로로히드록시알루미늄) 0.3 중량부를 더 혼합하여 잇몸질환 개선 효과가 우수한 구강세정용 조성물을 제조하였다.Proceed in the same manner as in Example 1, except that 0.03 parts by weight of fluorine component (sodium fluoride and sodium fluorophosphate mixed in a 1:1 ratio by weight) and 0.3 parts by weight of gum disease inhibitor (alantoin chlorohydroxyaluminum) are added to 100 parts by weight of purified water. By further mixing, an oral cleaning composition with excellent gum disease improvement effects was prepared.
<실시예 5><Example 5>
상기 실시예 2와 동일하게 진행하되, 상기 정제수 100 중량부 대비 불소성분(불화나트륨 및 불소인산나트륨이 1:1의 중량부로 혼합) 0.03 중량부 및 잇몸질환 억제제(알란토인클로로히드록시알루미늄) 0.3 중량부를 더 혼합하여 잇몸질환 개선 효과가 우수한 구강세정용 조성물을 제조하였다.Proceed in the same manner as in Example 2, except that 0.03 parts by weight of fluorine component (sodium fluoride and sodium fluorophosphate mixed in a 1:1 ratio by weight) and 0.3 parts by weight of gum disease inhibitor (alantoin chlorohydroxyaluminum) are added to 100 parts by weight of purified water. By further mixing, an oral cleaning composition with excellent gum disease improvement effects was prepared.
<실시예 6><Example 6>
상기 실시예 3과 동일하게 진행하되, 상기 정제수 100 중량부 대비 불소성분(불화나트륨 및 불소인산나트륨이 1:1의 중량부로 혼합) 0.03 중량부 및 잇몸질환 억제제(알란토인클로로히드록시알루미늄) 0.3 중량부를 더 혼합하여 잇몸질환 개선 효과가 우수한 구강세정용 조성물을 제조하였다.Proceed in the same manner as in Example 3, except that 0.03 parts by weight of the fluorine component (sodium fluoride and sodium fluorophosphate mixed in a 1:1 ratio by weight) and 0.3 parts by weight of gum disease inhibitor (alantoin chlorohydroxyaluminum) are added to 100 parts by weight of the purified water. By further mixing, an oral cleaning composition with excellent gum disease improvement effects was prepared.
<비교예 1><Comparative Example 1>
정제수 100 중량부, 정제염 2 중량부, 클로로헥시딘 0.2 중량부 및 상기 제조예 4를 통해 제조된 첨가제 1.5 중량부를 혼합하여 구강세정용 조성물을 제조하였다.An oral cleaning composition was prepared by mixing 100 parts by weight of purified water, 2 parts by weight of purified salt, 0.2 parts by weight of chlorhexidine, and 1.5 parts by weight of the additive prepared through Preparation Example 4.
<비교예 2><Comparative Example 2>
정제수 100 중량부, 상기 제조예 1을 통해 제조된 토판염 0.5 중량부, 클로로헥시딘 0.01 중량부, 상기 제조예 2를 통해 제조된 색소침착억제제 0.01 중량부, 상기 제조예 3을 통해 제조된 한약재 추출물 0.1 중량부 및 상기 제조예 4를 통해 제조된 첨가제 0.5 중량부를 혼합하여 구강세정용 조성물을 제조하였다.100 parts by weight of purified water, 0.5 parts by weight of topane salt prepared through Preparation Example 1, 0.01 part by weight of chlorhexidine, 0.01 part by weight of pigmentation inhibitor prepared through Preparation Example 2, An oral cleaning composition was prepared by mixing 0.1 part by weight of the herbal extract and 0.5 part by weight of the additive prepared in Preparation Example 4.
<비교예 3><Comparative Example 3>
정제수 100 중량부, 상기 제조예 1을 통해 제조된 토판염 5 중량부, 클로로헥시딘 0.5 중량부, 상기 제조예 2를 통해 제조된 색소침착억제제 1 중량부, 상기 제조예 3을 통해 제조된 한약재 추출물 2 중량부 및 상기 제조예 4를 통해 제조된 첨가제 5 중량부를 혼합하여 토판염이 함유되어 잇몸질환 개선 효과가 우수한 구강세정용 조성물을 제조하였다.100 parts by weight of purified water, 5 parts by weight of topane salt prepared through Preparation Example 1, 0.5 parts by weight of chlorhexidine, 1 part by weight of pigmentation inhibitor prepared through Preparation Example 2, 2 parts by weight of the herbal extract and 5 parts by weight of the additive prepared in Preparation Example 4 were mixed to prepare an oral cleaning composition containing topan salt and having an excellent gum disease improvement effect.
상기 실시예 1 내지 6 및 비교예 1 내지 3을 통해 제조된 구강 세정용 조성물의 맛, 향 및 전체적인 기호도를 측정하여 아래 표 1에 나타내었다.The taste, scent, and overall preference of the oral cleansing compositions prepared through Examples 1 to 6 and Comparative Examples 1 to 3 were measured and shown in Table 1 below.
{단, 구강 세정용 조성물의 맛, 향 및 전체적인 기호도는 피시험자 50명을 대상으로 하여 5점 척도법으로 조사한 후에 평균값으로 나타내는 방법을 이용하였다.{However, the taste, scent, and overall preference of the oral cleansing composition were surveyed using a 5-point scale method among 50 test subjects and then expressed as the average value.
5점:매우 우수, 4점:우수, 3점:보통, 2점:나쁨, 1점:매우 나쁨}5 points: very good, 4 points: excellent, 3 points: average, 2 points: bad, 1 point: very bad}
<표 1><Table 1>
상기 표 1에 나타낸 것처럼, 본 발명의 실시예 1 내지 6을 통해 제조된 구강세정용 조성물은 맛, 향, 전체적인 기호도가 우수한 것을 알 수 있다.As shown in Table 1, it can be seen that the oral cleansing compositions prepared through Examples 1 to 6 of the present invention are excellent in taste, aroma, and overall preference.
반면, 비교예 2를 통해 제조된 구강 세정용 조성물은 실시예 1과 동일한 성분이 함유되었음에도 불구하고, 유효성분들의 함량이 지나치게 낮아 전체적인 기호도가 저하되는 것을 알 수 있다.On the other hand, although the oral cleansing composition prepared through Comparative Example 2 contained the same ingredients as Example 1, the content of active ingredients was too low, resulting in a decrease in overall preference.
또한, 비교예 3과 같이 유효성분들의 함량이 과량으로 첨가되더라도 전체적인 기호도는 실시예 1에 비해 오히려 감소하는 것을 알 수 있다.In addition, it can be seen that even if the content of the active ingredients is added in excessive amounts as in Comparative Example 3, the overall preference is rather decreased compared to Example 1.
또한, 상기 실시예 1 내지 6 및 비교예 1 내지 3을 통해 제조된 구강 세정용 조성물의 잇몸자극 여부를 측정하여 아래 표 2에 나타내었다.In addition, the gum irritation of the oral cleaning compositions prepared through Examples 1 to 6 and Comparative Examples 1 to 3 was measured and shown in Table 2 below.
{단, 구강 세정용 조성물의 잇몸자극 여부는 피시험자 90명을 10명씩 9개 그룹으로 분류한 후에, 각 그룹별로 구강 세정용 조성물 10mL를 1분 동안 입에 머금도록 하여 시간의 흐름에 따른 잇몸자극 여부를 3점 척도법으로 측정한 후에 평균값으로 나타내는 방법을 이용하였다.{However, to determine whether the oral cleaning composition irritates the gums, 90 test subjects were divided into 9 groups of 10 each, and each group was asked to hold 10 mL of the oral cleaning composition in their mouths for 1 minute to determine the effect of gum irritation over time. A method of measuring stimulation using a 3-point scale and then expressing it as an average value was used.
3점:매우 자극, 2점:약각 자극, 1점:자극 없음}3 points: very irritating, 2 points: mildly irritating, 1 point: no irritation}
<표 2><Table 2>
상기 표 2에 나타낸 것처럼, 본 발명의 실시예 1 내지 6을 통해 제조된 구강세정용 조성물은 잇몸자극성이 낮은 것을 알 수 있다.As shown in Table 2, it can be seen that the oral cleaning compositions prepared through Examples 1 to 6 of the present invention have low gum irritation.
반면, 비교예 3을 통해 제조된 구강세정용 조성물은 유효성분들이 과량으로 함유되어 비교적 잇몸자극성이 높게 나타나는 것을 알 수 있다.On the other hand, it can be seen that the composition for oral cleaning prepared through Comparative Example 3 contained an excessive amount of active ingredients, resulting in relatively high gum irritation.
또한, 상기 실시예 1 내지 6 및 비교예 1 내지 3을 통해 제조된 구강 세정용 조성물의 잇몸질환 개선 효과 및 구취제거 효과를 측정하여 아래 표 3에 나타내었다.In addition, the gum disease improvement effect and bad breath removal effect of the oral cleaning composition prepared through Examples 1 to 6 and Comparative Examples 1 to 3 were measured and shown in Table 3 below.
{단, 잇몸질환 개선 효과는 치은염 질환이 있는 피시험자 20명을 대상으로 하여 제조된 구강세정용 조성물 5mL를 아침 저녁으로 1분 동안 머금게 하는 과정을 한달 동안 시행하도록 한 후에, 구강세정용 조성물의 처리전과 비교하여 치은염 질환의 개선여부를 5점 척도법으로 조사한 후에 평균값으로 나타내는 방법을 이용하였다.{However, the effect of improving gum disease was determined by subjecting 20 test subjects with gingivitis disease to 5 mL of the oral cleaning composition prepared in the morning and evening for 1 minute for one month. Compared to before treatment, the improvement of gingivitis disease was investigated using a 5-point scale method and then expressed as an average value.
5점:매우 개선, 4점:개선, 3점:보통, 2점:악화, 1점:매우 악화5 points: very improved, 4 points: improved, 3 points: average, 2 points: worsened, 1 point: very worsened
또한, 구취제거 효과는 평소 구취가 일반인에 비해 심하게 발생하는 피시험자 30명을 대상으로 하여 구강세정용 조성물 5mL를 1분 동안 머금게 한 후에, 1시간 후에 구취개선 여부를 5점 척도법으로 조사한 후에 평균값으로 나타내는 방법을 이용하였다.}In addition, the bad breath removal effect was determined by subjecting 30 test subjects who usually have more bad breath than the general public to soaking 5 mL of the oral cleansing composition for 1 minute, and then examining whether bad breath was improved after 1 hour using a 5-point scale. The average value was obtained. The method indicated as was used.}
<표 3><Table 3>
상기 표 3에 나타낸 것처럼, 본 발명의 실시예 1 내지 6을 통해 제조된 구강세정용 조성물이 적용되면 치은염과 같은 잇몸질환과 구취가 개선되는 것을 알 수 있으며, 불소성분과 잇몸질환 억제제가 더 함유된 실시예 4 내지 6의 잇몸질환 개선 효과와 구취제거 효과가 더욱 우수한 것을 알 수 있다.As shown in Table 3, it can be seen that gum disease such as gingivitis and bad breath are improved when the oral cleaning composition prepared through Examples 1 to 6 of the present invention is applied, and it further contains fluorine and gum disease inhibitors. It can be seen that the gum disease improvement effect and bad breath removal effect of Examples 4 to 6 are more excellent.
반면, 토판염이 함유되지 않은 비교예 1과 유효성분의 함량이 지나치게 낮은 비교예 2의 구강세정용 조성물은 잇몸질환 개선 효과와 구취개선 효과가 상대적으로 미미한 것을 알 수 있다.On the other hand, it can be seen that the oral cleansing compositions of Comparative Example 1, which did not contain topan salt, and Comparative Example 2, which had an excessively low content of active ingredients, had relatively little gum disease improvement and bad breath improvement effects.
또한, 비교예 3과 같이 유효성분이 과량 함유되더라도, 잇몸질환 개선 효과나 구취제거 효과는 크게 향상되지 않는 것을 알 수 있다.In addition, it can be seen that even if the active ingredient is contained in excessive amounts as in Comparative Example 3, the gum disease improvement effect or bad breath removal effect is not significantly improved.
따라서, 본 발명에 따른 토판염이 함유되어 잇몸질환 개선 효과가 우수한 구강세정용 조성물은 토판염이 함유되어 우수한 잇몸질환 개선 효과를 나타낼 뿐만 아니라, 우수한 기호도를 나타내면서도 충치억제 및 구취제거 효과를 나타낸다.Therefore, the oral cleaning composition containing topan salt according to the present invention, which has an excellent gum disease improvement effect, not only exhibits an excellent gum disease improvement effect by containing topan salt, but also exhibits excellent acceptability while also exhibiting cavity suppression and bad breath removal effects. .
Claims (5)
상기 색소침착억제제는 메타중아황산염, 아스코르브산, 히알루론산 및 폴리비닐피롤리돈비닐아세테이트가 1:1:1:1의 중량부로 혼합되어 이루어지고,
상기 한약재 추출물은 정제수 100 중량부에 덖음된 한약재 12 중량부를 혼합하고 85℃의 온도로 4시간 동안 가열하여 제조되며,
상기 덖음된 한약재는 목단피, 백지, 세신, 박하, 백리향, 해열목, 가시오가피, 버드나무, 무환자, 산골취 및 개똥쑥을 동일한 중량부로 혼합하여 이루어진 혼합물을 75℃의 온도로 30분 동안 덖음하여 이루어지고,
상기 불소성분은 불화나트륨 및 불소인산나트륨이 1:1의 중량부로 혼합되어 이루어지며,
상기 잇몸질환 억제제는 알란토인클로로히드록시알루미늄으로 이루어지고,
상기 첨가제는 D-소르비톨액 100 중량부, 식물성 글리세린 5 중량부, 코코베타인 12 중량부, 구연산 수화물 0.01 중량부 및 천연감미료 1.25 중량부로 이루어지며,
상기 천연감미료는 프락토올리고당 100 중량부에 스테비아 10 중량부가 혼합되어 이루어지는 것을 특징으로 하는 토판염이 함유되어 잇몸질환 개선 효과가 우수한 구강세정용 조성물.
It consists of 100 parts by weight of purified water, 3 parts by weight of tophan salt, 0.3 parts by weight of chlorhexidine, 0.5 parts by weight of pigmentation inhibitor, 1 part by weight of herbal extract, 0.03 part by weight of fluorine, 0.3 part by weight of gum disease inhibitor, and 3 parts by weight of additives. Lose,
The pigmentation inhibitor is made by mixing metabisulfite, ascorbic acid, hyaluronic acid, and polyvinylpyrrolidone vinyl acetate in a weight ratio of 1:1:1:1,
The herbal medicine extract is prepared by mixing 12 parts by weight of the mixed herbal medicine with 100 parts by weight of purified water and heating at a temperature of 85 ° C. for 4 hours,
The boiled herbal medicine is made by mixing equal parts by weight of dandelion bark, white paper, sesame seeds, peppermint, thyme, antipyretic tree, acanthus acanthus, willow, radish root, mountain golchwi, and artemisia, and boiling the mixture at a temperature of 75°C for 30 minutes. under,
The fluorine component is made by mixing sodium fluoride and sodium fluorophosphate in a 1:1 ratio by weight,
The gum disease inhibitor consists of allantoin chlorohydroxyaluminum,
The additive consists of 100 parts by weight of D-sorbitol solution, 5 parts by weight of vegetable glycerin, 12 parts by weight of coco betaine, 0.01 part by weight of citric acid hydrate, and 1.25 parts by weight of natural sweetener,
The natural sweetener is an oral cleansing composition containing 100 parts by weight of fructo-oligosaccharide and 10 parts by weight of stevia, which is excellent in improving gum disease by containing tophan salt.
상기 토판염은 염전에 200 내지 300 메쉬의 천연 게르마늄 분말을 살포한 후에, 염전 바닥을 10 내지 20 센티미터의 깊이로 갈아 토판을 형성하고,
상기 토판이 형성된 염전에 염도가 23 내지 25%로 농축된 해수를 투입한 후에 해수를 증발시키는 과정으로 제조되는 것을 특징으로 하는 토판염이 함유되어 잇몸질환 개선 효과가 우수한 구강세정용 조성물.
In claim 1,
The earthen salt is made by spraying natural germanium powder of 200 to 300 mesh into the salt pond, then plowing the bottom of the salt pond to a depth of 10 to 20 centimeters to form a earthen plate,
An oral cleansing composition containing topane salt, which is manufactured by adding seawater concentrated to a salinity of 23 to 25% into the salt pan where the tophan salt is formed, and then evaporating the sea water.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020230067501A KR102666564B1 (en) | 2023-05-25 | 2023-05-25 | Mouthwash composition with excellent effect of improving gum disease by containing topan salt |
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Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100769573B1 (en) | 2001-07-02 | 2007-10-23 | 주식회사 엘지생활건강 | Composition for tablet oral cavity washing agent containing enzymes |
| KR100827182B1 (en) * | 2006-12-08 | 2008-05-02 | 김기영 | Liquid-type dentifrice composition contained silver particles and mousse-type dentifrice using the same |
| KR20110107754A (en) * | 2010-03-25 | 2011-10-04 | 김신익 | Manufacturing method of sun-dried salt enhanced mineral and sun-dried salt using the same |
| KR20130005549A (en) * | 2011-07-06 | 2013-01-16 | 양시진 | Composition for cleaning the oral using soil-board salt and manufacturing method thereof |
| KR20160065228A (en) * | 2014-11-28 | 2016-06-09 | 재단법인 한국한방산업진흥원 | Orally disintegrating tablet for preventing or treating throat pain or throat inflammation |
| KR101675443B1 (en) | 2014-10-21 | 2016-11-17 | 이상수 | composition for oral cavity wash and production method thereof |
| KR20180002480A (en) * | 2015-05-08 | 2018-01-08 | 쿠라셉트 에이디에스 에스.알.엘. | Improved Mouthwash Preparation |
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2023
- 2023-05-25 KR KR1020230067501A patent/KR102666564B1/en active IP Right Grant
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100769573B1 (en) | 2001-07-02 | 2007-10-23 | 주식회사 엘지생활건강 | Composition for tablet oral cavity washing agent containing enzymes |
| KR100827182B1 (en) * | 2006-12-08 | 2008-05-02 | 김기영 | Liquid-type dentifrice composition contained silver particles and mousse-type dentifrice using the same |
| KR20110107754A (en) * | 2010-03-25 | 2011-10-04 | 김신익 | Manufacturing method of sun-dried salt enhanced mineral and sun-dried salt using the same |
| KR20130005549A (en) * | 2011-07-06 | 2013-01-16 | 양시진 | Composition for cleaning the oral using soil-board salt and manufacturing method thereof |
| KR101675443B1 (en) | 2014-10-21 | 2016-11-17 | 이상수 | composition for oral cavity wash and production method thereof |
| KR20160065228A (en) * | 2014-11-28 | 2016-06-09 | 재단법인 한국한방산업진흥원 | Orally disintegrating tablet for preventing or treating throat pain or throat inflammation |
| KR20180002480A (en) * | 2015-05-08 | 2018-01-08 | 쿠라셉트 에이디에스 에스.알.엘. | Improved Mouthwash Preparation |
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