KR102641319B1 - Cosmetic composition having an effect of improving skin barrier and inflammation - Google Patents
Cosmetic composition having an effect of improving skin barrier and inflammation Download PDFInfo
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- KR102641319B1 KR102641319B1 KR1020230099682A KR20230099682A KR102641319B1 KR 102641319 B1 KR102641319 B1 KR 102641319B1 KR 1020230099682 A KR1020230099682 A KR 1020230099682A KR 20230099682 A KR20230099682 A KR 20230099682A KR 102641319 B1 KR102641319 B1 KR 102641319B1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Botany (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
Abstract
본 발명은 피부장벽 및 염증 개선 효과를 갖는 화장료 조성물에 관한 것으로, 본 발명에 따르면, 왕벚나무꽃 추출물, 복사나무꽃 추출물 및 국화꽃 추출물을 4.0 내지 4.8 : 0.4 내지 2 : 4.0 내지 4.8의 중량비로 포함하는 꽃 추출물을 함유하는 피부장벽 및 염증 개선 효과를 갖는 화장료 조성물을 제공할 수 있다.The present invention relates to a cosmetic composition having a skin barrier and inflammation improving effect. According to the present invention, Yoshino cherry blossom extract, prickly peach blossom extract and chrysanthemum flower extract are mixed in a weight ratio of 4.0 to 4.8:0.4 to 2:4.0 to 4.8. It is possible to provide a cosmetic composition containing a flower extract containing a skin barrier and inflammation improving effect.
Description
본 발명은 피부장벽 및 염증 개선 효과를 갖는 화장료 조성물에 관한 것으로, 더욱 자세하게는 왕벚나무꽃, 복사나무꽃 및 국화꽃의 추출물을 혼합하여 사용함으로써, 우수한 피부장벽 및 염증 개선 효과를 갖는 화장료 조성물에 관한 것이다.The present invention relates to a cosmetic composition having a skin barrier and inflammation improving effect, and more specifically, to a cosmetic composition having an excellent skin barrier and inflammation improving effect by using a mixture of extracts of Yoshino cherry blossoms, prickly peach blossoms, and chrysanthemum flowers. It's about.
최근 환경의 변화나 생활 패턴의 변화에 따른 냉/난방의 인위적인 온도 조절, 사회생활에서 발생되는 각종 스트레스와 환경오염으로 인한 피부 스트레스, 화장 습관에 따른 잦은 세안 및 연령 증가에 따른 자연적인 피부 노화 등의 여러 가지 원인으로 인하여 각질층의 수분이 감소하여 피부가 건조해지고 표면이 거칠게 되며 피부가 푸석거리고 촉촉함을 잃어 생기가 없어 보이는 등의 현상이 발생하기 때문에 피부 장벽 강화용 또는 피부 보습용 조성물의 필요가 증가하고 있다.Artificial temperature control of cooling/heating due to recent environmental changes or changes in lifestyle patterns, skin stress due to various stresses and environmental pollution occurring in social life, frequent face washing due to makeup habits, natural skin aging due to age, etc. Due to various causes, the moisture in the stratum corneum decreases, causing the skin to dry out, the surface to become rough, the skin to become dull, lose moisture, and appear lifeless. Therefore, there is a need for a composition for strengthening the skin barrier or moisturizing the skin. It is increasing.
여기서 피부보습을 유지하는 대표적인 인자인 히알루론산(hyaluronic acid, HA)은 콜라겐, 엘라스틴과 함께 피부 3대 요소가운데 하나로, 친수성이 강해 물과 결합하여 겔을 형성하는 성질이 있어 피부 수분 유지에 중요한 역할을 하는 천연 보습제로 알려져 있다.Here, hyaluronic acid (HA), a representative factor that maintains skin moisture, is one of the three major skin elements along with collagen and elastin. It is highly hydrophilic and has the property of combining with water to form a gel, playing an important role in maintaining skin moisture. It is known as a natural moisturizer.
따라서 히알루론산의 합성을 유도하거나 분해를 억제하는 물질은 피부 보습과 노화 방지에 효과적이며, 특히 히알루론산 합성효소(hyaluronic acid synthase, HAS) 중 HAS2와 HAS3는 히알루론산 합성에 결정적인 역할을 하는 것으로 알려져 있고, 최근 HAS의 유전자 발현 증가를 통해 히알루론산의 생산을 촉진시키고자 하는 연구가 활발하게 이루어지고 있다.Therefore, substances that induce the synthesis of hyaluronic acid or inhibit its decomposition are effective in moisturizing the skin and preventing aging. In particular, HAS2 and HAS3 among hyaluronic acid synthase (HAS) enzymes are known to play a critical role in hyaluronic acid synthesis. , Recently, research has been actively conducted to promote the production of hyaluronic acid by increasing the gene expression of HAS.
한편, 염증 반응은 외부 자극에 대한 생체조직의 방어반응의 하나로서 물리적 작용이나 유해물질, 화학적 자극, 세균 감염 등에 의한 손상을 수복 재생하려는 기전이며, 지속적인 염증반응은 오히려 점막손상을 촉진하고, 그 결과 일부에서는 암 발생 등 각종 질환을 유도한다. 특히, 피부염은 피부에 생긴 염증으로 발적, 종창, 열감 및 동통 증상을 동반한다. 자각증상으로 아픔보다 가려움을 더 느끼는 것이 보통이다.On the other hand, the inflammatory response is one of the defense responses of biological tissues to external stimuli and is a mechanism to repair and regenerate damage caused by physical actions, harmful substances, chemical stimulation, bacterial infection, etc., and a continuous inflammatory response actually promotes mucosal damage and causes damage to the mucous membrane. As a result, in some cases, it leads to various diseases, including cancer. In particular, dermatitis is an inflammation of the skin that is accompanied by symptoms of redness, swelling, heat, and pain. It is common to feel itchiness more than pain as a subjective symptom.
일반적으로 피부염은 아토피성 피부염, 1차성 자극성 피부염, 접촉 피부염, 지루성 피부염과 같이 습진성 피부염 및 선상 피부염, 독나방 피부염 등 곤충이 원인인 피부염이 있다.In general, dermatitis includes atopic dermatitis, primary irritant dermatitis, contact dermatitis, and seborrheic dermatitis, as well as dermatitis caused by insects, such as eczematous dermatitis, glandular dermatitis, and poison moth dermatitis.
이러한 피부염의 치료에는 스테로이드제제, 항히스타민제제를 처방하는 것이 일반적이다. 하지만, 국소 부신피 질호르몬 같은 스테로이드제제를 장기간 사용하는 경우, 피부위축, 혈관확장 및 색소탈실 등의 문제가 발생될 수 있으며, 항히스타민제제의 경우 내성 및 과민반응이 나타날 수 있다. 이에 종래 피부염 치료제의 문제점을 보완할 안전한 물질로 천연 유래 물질을 이용한 새로운 피부염 치료제 개발이 요구되고 있다.To treat this type of dermatitis, it is common to prescribe steroids and antihistamines. However, when steroid drugs such as topical corticosteroids are used for a long time, problems such as skin atrophy, vasodilation, and loss of pigmentation may occur, and in the case of antihistamine drugs, resistance and hypersensitivity reactions may occur. Accordingly, there is a need to develop a new dermatitis treatment using natural substances as a safe substance to complement the problems of conventional dermatitis treatments.
따라서, 피부장벽(보습)과 항염(염증 개선) 효과를 가지는 조성물에 대한 개발이 필요한 실정이다. 종래의 기술로 한국등록특허 제10-1777799호 "국화 숙성물 함유 화장료 조성물"이 공개되어 있다.Therefore, there is a need to develop a composition that has skin barrier (moisturizing) and anti-inflammatory (inflammation improvement) effects. As a conventional technology, Korean Patent No. 10-1777799, “Cosmetic composition containing ripened chrysanthemum,” has been disclosed.
이에 본 발명에서는 남원·지리산권 자원식물 중 왕벚나무꽃, 복사나무꽃, 국화꽃 추출물을 이용하여 염증 개선 효과에 최적화된 화장료 조성물을 개발하고자 한다.Accordingly, the present invention seeks to develop a cosmetic composition optimized for the inflammation improvement effect using extracts of cherry blossoms, prickly peach blossoms, and chrysanthemum flowers among resource plants in the Namwon-Jiri Mountain area.
상기와 같은 문제를 해결하고자, 본 발명은 왕벚나무꽃, 복사나무꽃 및 국화꽃의 추출물을 혼합하여 사용함으로써, 우수한 피부장벽 및 염증 개선 효과를 갖는 화장료 조성물을 제공하는데 목적이 있다.In order to solve the above problems, the purpose of the present invention is to provide a cosmetic composition that has excellent skin barrier and inflammation improvement effects by using a mixture of extracts of Yoshino cherry blossoms, prickly peach blossoms, and chrysanthemum flowers.
상기와 같은 과제를 해결하기 위하여, 본 발명의 실시예에 따른 피부장벽 및 염증 개선 효과를 갖는 화장료 조성물은 왕벚나무꽃 추출물, 복사나무꽃 추출물 및 국화꽃 추출물을 4.0 내지 4.8 : 0.4 내지 2 : 4.0 내지 4.8의 중량비로 포함하는 꽃 추출물을 함유하는 피부장벽 및 염증 개선 효과를 갖는 화장료 조성물을 제공할 수 있다.In order to solve the above problems, a cosmetic composition having a skin barrier and inflammation improving effect according to an embodiment of the present invention is prepared by mixing Yoshino cherry blossom extract, prickly peach blossom extract, and chrysanthemum flower extract at a ratio of 4.0 to 4.8:0.4 to 2:4.0. It is possible to provide a cosmetic composition having a skin barrier and inflammation improvement effect containing a flower extract at a weight ratio of 4.8 to 4.8.
여기서, 상기 왕벚나무꽃 추출물, 복사나무꽃 추출물 및 국화꽃 추출물은, 왕벚나무꽃, 복사나무꽃, 국화꽃을 각각 물 또는 유기용매의 용매로 추출한 것을 특징으로 한다.Here, the Yoshino cherry blossom extract, Aspiana tree flower extract, and Chrysanthemum flower extract are characterized by extracting Yoshino cherry blossoms, Asparagus flowers, and Chrysanthemum flowers with water or an organic solvent, respectively.
또한 상기 꽃 추출물은, 상기 화장료 조성물 전체 중량에 대하여, 3 내지 10중량%로 함유되는 것을 특징으로 한다.In addition, the flower extract is characterized in that it is contained in an amount of 3 to 10% by weight based on the total weight of the cosmetic composition.
또한 유액, 크림, 화장수, 에센스, 팩, 현탁액, 페이스트, 젤, 파우더, 립스틱, 메이컵 베이스, 파운데이션, 로션, 겔, 패취, 미용액, 클렌징 폼, 클렌징 크림, 클렌징 워터, 비누, 샴푸, 린스 및 분무제 중 하나의 제형인 것을 특징으로 한다.Also, emulsion, cream, lotion, essence, pack, suspension, paste, gel, powder, lipstick, makeup base, foundation, lotion, gel, patch, serum, cleansing foam, cleansing cream, cleansing water, soap, shampoo, rinse and It is characterized as being one of the spray formulations.
상기와 같은 본 발명의 실시예에 따른 피부장벽 및 염증 개선 효과를 갖는 화장료 조성물은 왕벚나무꽃, 복사나무꽃 및 국화꽃으로부터 추출된 추출물을 포함하는 꽃 추출물을 함유함으로써, 보습 기능을 통해 각질층 손상을 방지하여 우수한 피부장벽 개선 효과를 가질 수 있다.The cosmetic composition having the effect of improving the skin barrier and inflammation according to the embodiment of the present invention as described above contains flower extracts including extracts extracted from cherry blossoms, prickly peach blossoms, and chrysanthemum flowers, thereby damaging the stratum corneum through a moisturizing function. It can have an excellent skin barrier improvement effect by preventing .
또한 우수한 염증 개선 효과를 가질 수 있으며, 이에 홍조, 브라운색소, 색소침착 등을 개선시킬 수 있다.It can also have an excellent inflammation-improving effect, thereby improving redness, brown pigmentation, pigmentation, etc.
또한 서로 상관관계가 있는 피부장벽(보습)과 염증 개선 기능이 같이 작용됨으로써 보다 효과가 극대화될 수 있다.In addition, the effect can be maximized by working together with the skin barrier (moisturizing) and inflammation-improving functions, which are correlated with each other.
도 1은 제조예와 실시예의 NO 생성율을 나타낸 그래프.
도 2의 (a) 및 (b)는 화장료 조성물 사용 전/사용 후에 따른 각질층 수분 함량과 수분 개선율을 나타낸 그래프.
도 3의 (a) 및 (b)는 화장료 조성물 사용 전/ 사용 후에 따른 경피 수분 손실량 및 피부장벽 개선율을 나타낸 그래프.
도 4의 (a) 및 (b)는 화장료 조성물 사용 전/사용 후에 따른 홍조 면적당 백분율 및 홍조 개선율을 나타낸 그래프.
도 5의 (a) 및 (b)는 화장료 조성물 사용 전/사용 후에 따른 브라운 색소 면적당 백분율 및 브라운색소 개선율을 나타낸 그래프.
도 6의 (a) 및 (b)는 화장료 조성물 사용 전/사용 후에 따른 색소침착 면적당 백분율 및 색소침착 개선율을 나타낸 그래프.1 is a graph showing the NO production rate of preparation examples and examples.
Figures 2 (a) and (b) are graphs showing the moisture content of the stratum corneum and moisture improvement rate before and after use of the cosmetic composition.
Figures 3 (a) and (b) are graphs showing transdermal moisture loss and skin barrier improvement rate before and after use of the cosmetic composition.
Figures 4 (a) and (b) are graphs showing the percentage per flushing area and the improvement rate of flushing before and after using the cosmetic composition.
Figures 5 (a) and (b) are graphs showing the percentage per area of brown pigment and the improvement rate of brown pigment before and after use of the cosmetic composition.
Figures 6 (a) and (b) are graphs showing the percentage per area of pigmentation and the improvement rate of pigmentation before and after use of the cosmetic composition.
이하, 도면을 참조한 본 발명의 설명은 특정한 실시 형태에 대해 한정되지 않으며, 다양한 변환을 가할 수 있고 여러 가지 실시예를 가질 수 있다. 또한, 이하에서 설명하는 내용은 본 발명의 사상 및 기술 범위에 포함되는 모든 변환, 균등물 내지 대체물을 포함하는 것으로 이해되어야 한다.Hereinafter, the description of the present invention with reference to the drawings is not limited to specific embodiments, and various changes may be made and various embodiments may be possible. In addition, the content described below should be understood to include all conversions, equivalents, and substitutes included in the spirit and technical scope of the present invention.
이하의 설명에서 제1, 제2 등의 용어는 다양한 구성요소들을 설명하는데 사용되는 용어로서, 그 자체에 의미가 한정되지 아니하며, 하나의 구성요소를 다른 구성요소로부터 구별하는 목적으로만 사용된다.In the following description, the terms first, second, etc. are terms used to describe various components, and their meaning is not limited, and is used only for the purpose of distinguishing one component from other components.
본 명세서 전체에 걸쳐 사용되는 동일한 참조번호는 동일한 구성요소를 나타낸다.Like reference numerals used throughout this specification refer to like elements.
본 발명에서 사용되는 단수의 표현은 문맥상 명백하게 다르게 뜻하지 않는 한, 복수의 표현을 포함한다. 또한, 이하에서 기재되는 "포함하다", "구비하다" 또는 "가지다" 등의 용어는 명세서상에 기재된 특징, 숫자, 단계, 동작, 구성요소, 부품 또는 이들을 조합한 것이 존재함을 지정하려는 것으로 해석되어야 하며, 하나 또는 그 이상의 다른 특징들이나, 숫자, 단계, 동작, 구성요소, 부품 또는 이들을 조합한 것들의 존재 또는 부가 가능성을 미리 배제하지 않는 것으로 이해되어야 한다.As used herein, singular expressions include plural expressions, unless the context clearly dictates otherwise. In addition, terms such as “comprise,” “provide,” or “have” used below are intended to designate the presence of features, numbers, steps, operations, components, parts, or a combination thereof described in the specification. It should be construed and understood as not excluding in advance the possibility of the presence or addition of one or more other features, numbers, steps, operations, components, parts or combinations thereof.
본 발명의 실시예에 따른 피부장벽 및 염증 개선 효과를 갖는 화장료 조성물은(이하 '화장료 조성물'이라 함)은 왕벚나무꽃, 복사나무꽃 및 국화꽃 으로부터 추출된 꽃 추출물을 함유하여, 보다 우수한 피부장벽 및 염증 개선 효과를 나타낼 수 있는 화장료 조성물을 제공하고자 한다.The cosmetic composition having the effect of improving skin barrier and inflammation according to an embodiment of the present invention (hereinafter referred to as 'cosmetic composition') contains flower extracts extracted from Yoshino cherry blossoms, prickly peach blossoms and chrysanthemum flowers, thereby providing better skin. The aim is to provide a cosmetic composition that can exhibit barrier and inflammation improvement effects.
이는 피부염으로 각질층이 손상되면 수분 감소로 이어질 수 있고, 수분 손실량이 증가하면 건조에 의해 가려움 등으로 이어져 피부염을 유발하는 등 서로 상관관계를 가지는 피부장벽(보습)과 염증에 대한 개선 효과가 같이 나타남으로써, 효과가 보다 극대화되도록 할 수 있는 것이다.This can lead to a decrease in moisture when the stratum corneum is damaged due to dermatitis, and when the amount of moisture loss increases, it leads to itchiness due to dryness, causing dermatitis. The effect of improving the skin barrier (moisturizing) and inflammation, which are interrelated, appears together. In this way, the effect can be maximized.
먼저, 꽃 추출물에 포함되는 왕벚나무꽃 추출물은 항염 작용을 하고 히알루론산 분비능을 가져 보습 효과를 나타내며, 폴리페놀, 플라보노이드를 함유하고 DPPH 라디칼 소거능을 가지고 있어 항산화 효과를 통해 활성 산소를 효과적으로 감소시키고 세포를 보호하여 각질층의 손상을 방지할 수 있다.First, the Yoshino cherry blossom extract included in the flower extract has an anti-inflammatory effect and has the ability to secrete hyaluronic acid, showing a moisturizing effect. It contains polyphenols and flavonoids, and has DPPH radical scavenging ability, so it effectively reduces free radicals through its antioxidant effect and protects cells. It can prevent damage to the stratum corneum by protecting it.
또한 복사나무꽃 추출물은 항염 작용을 하고 피부 보습에 관련된 HAS-2를 발현시킬 수 있고, 멜라닌생성 및 티로시나제활성 억제능을 가져 미백 효과를 나타낼 수 있고, 피부에 영양을 공급하고 엘라스타제활성 억제능을 통해 피부에 활력이 생기도록 도움을 줄 수 있어 주름 개선 효과를 가질 수 있으며, 폴리페놀, 플라보노이드를 함유하고 DPPH 라디칼 소거능을 가지고 있어 항산화 효과를 나타낼 수 있다.In addition, peach tree flower extract has an anti-inflammatory effect, can express HAS-2 related to skin moisturization, has the ability to inhibit melanin production and tyrosinase activity, can have a whitening effect, provides nutrition to the skin, and has the ability to inhibit elastase activity. It can help revitalize the skin and have an anti-wrinkle effect. It contains polyphenols and flavonoids and has DPPH radical scavenging ability, so it can have an antioxidant effect.
또한 국화꽃 추출물은 우수한 히알루론산 생성능을 가져 보습효과가 뛰어나 속 건조를 잡아줄 수 있고 수분 손실을 야기하는 각질에 대한 제거 기능을 나타낼 수 있으며, 폴리페놀 및 플라보노이드를 함유하고 DPPH 라디칼 소거능을 가지고 있어 항산화 효과를 나타내고, 비타민A, B1, C 그 외 각종 영양소가 풍부해 아토피, 두드러기 등 피부질환, 염증 개선에 도움이 될 수 있다. 또한 콜라겐 분해효소 억제능, 콜라겐 합성능, 엘라스타제활성 억제능을 통해 주름 개선 효과를 나타내며, 티로시나제활성 억제능을 가져 미백 효과도 나타낼 수 있다.In addition, chrysanthemum flower extract has an excellent hyaluronic acid production ability, has an excellent moisturizing effect, can prevent internal dryness, and can remove dead skin cells that cause moisture loss. It contains polyphenols and flavonoids and has DPPH radical scavenging ability. It has an antioxidant effect and is rich in vitamins A, B1, C and other nutrients, so it can help improve inflammation and skin diseases such as atopy and hives. In addition, it has a wrinkle-improving effect through its ability to inhibit collagen decomposition enzymes, collagen synthesis, and elastase activity, and can also have a whitening effect due to its ability to inhibit tyrosinase activity.
이러한 왕벚나무꽃 추출물, 복사나무꽃 추출물, 국화꽃 추출물을 혼합하여 꽃 추출물로 사용함으로써 본 발명은 피부장벽 및 염증 개선 효과가 보다 더 우수하게 나타나도록 하며, 피부장벽 손상에 따른 색소 침착, 염증 발생 등과 염증에 따른 홍조 등을 방지하고자 한다.By mixing the cherry blossom extract, prickly peach blossom extract, and chrysanthemum flower extract and using them as a flower extract, the present invention has a better effect on improving the skin barrier and inflammation, and causes pigmentation and inflammation due to damage to the skin barrier. This is to prevent redness due to inflammation in the back.
이때, 왕벚나무꽃 추출물, 복사나무꽃 추출물 및 국화꽃 추출물은 왕벚나무꽃, 복사나무꽃, 국화꽃을 각각 물 또는 유기용매의 용매로 추출한 것으로 제조할 수 있다.At this time, the Yoshino cherry blossom extract, the peach tree flower extract, and the chrysanthemum flower extract can be prepared by extracting the Yoshino cherry blossom, peach tree flower, and chrysanthemum flower with water or an organic solvent, respectively.
여기서 사용되는 왕벚나무꽃, 복사나무꽃, 국화꽃은 남원·지리산권 자원식물로, 남원시에서 채취하고 건조시켜 사용될 수 있는데, 35 내지 45℃에서 24시간 내지 72시간 건조한 것을 사용할 수 있고, 42℃에서 48시간 건조시킨 것을 사용하는 것이 바람직하다.The cherry blossoms, peach blossoms, and chrysanthemums used here are resource plants from the Namwon and Jirisan regions, and can be collected and dried in Namwon City. They can be dried at 35 to 45°C for 24 to 72 hours, and dried at 42°C. It is preferable to use something that has been dried for 48 hours.
이때, 건조 온도가 35℃미만일 경우 건조시간이 너무 오래걸리거나 수분 증발이 잘 이루어지지 않아 추출 효율이 저하될 수 있으며, 45℃를 초과할 경우 타거나 유효성분에 파괴, 변형 등이 일어날 수 있다.At this time, if the drying temperature is less than 35℃, the drying time may be too long or moisture may not evaporate properly, which may reduce extraction efficiency. If it exceeds 45℃, burning or destruction or deformation of the active ingredients may occur. .
또한, 건조 시간이 24시간 미만일 경우 건조가 잘 이루어지지 않고, 72시간을 초과할 경우 이미 건조가 충분히 이루어져 있기 때문에 비효율적이며 오히려 추출 효율이 저하될 수 있다.In addition, if the drying time is less than 24 hours, drying does not occur well, and if it exceeds 72 hours, it is inefficient because drying has already occurred sufficiently, and extraction efficiency may decrease.
유기용매는 에탄올 또는 1,3-부틸렌글리콜(1,3-butylene glycol)이 바람직하나, 메탄올, 이소프로탄올, 부탄올 등도 사용할 수 있다. 또한, 에탄올을 사용할 경우 50% 에탄올을 사용하는 것이 바람직하나, 이는 본 발명의 실시예에 불과하므로 한정되지는 않는다.The organic solvent is preferably ethanol or 1,3-butylene glycol, but methanol, isopropanol, butanol, etc. can also be used. In addition, when using ethanol, it is preferable to use 50% ethanol, but this is only an example of the present invention and is not limited.
더욱 구체적으로, 왕벚나무꽃 추출물 또는 복사나무꽃 추출물 또는 국화꽃 추출물은 원료(왕벚나무꽃 또는 복사나무꽃 또는 국화꽃) 4 내지 6중량부에 95 내지 100중량부의 물 또는 유기용매를 첨가하고 가열한 후 농축시키고 동결건조하여 제조될 수 있다. 이때, 원료 5중량부에 95중량부의 물 또는 유기용매를 첨가하는 것이 바람직하다.More specifically, the Yoshino cherry blossom extract or the peach tree flower extract or the chrysanthemum flower extract is obtained by adding 95 to 100 parts by weight of water or an organic solvent to 4 to 6 parts by weight of the raw material (i.e., the Yoshino cherry blossom, peach tree flower, or chrysanthemum flower) and heating. It can be prepared by concentrating and freeze-drying. At this time, it is preferable to add 95 parts by weight of water or organic solvent to 5 parts by weight of the raw material.
이 경우 원료가 4중량부 미만일 경우 추출물의 효능이 적게 나타나고 6중량부를 초과할 경우 화장료의 관능적인 특성인 향과 색상에 영향을 미칠 수 있기 때문이다.In this case, if the raw material is less than 4 parts by weight, the efficacy of the extract is reduced, and if it exceeds 6 parts by weight, it may affect the fragrance and color, which are the sensory characteristics of the cosmetic.
또한, 용매가 95중량부 미만일 경우 유효성분이 완전히 침출되지 않고 약간만 증발해도 추출액이 농축되고, 추출액의 유효성분이 과다한 열에 의해 국소적으로 파괴될 수 있으며, 100중량부 초과일 경우 유효성분의 용출량은 증가할 수 있으나 동결건조 시 비효율적이다.In addition, if the solvent is less than 95 parts by weight, the active ingredient is not completely leached and the extract is concentrated even if it evaporates only slightly, and the active ingredient in the extract may be locally destroyed by excessive heat. If the solvent is more than 100 parts by weight, the amount of active ingredient eluted increases. It can be done, but it is inefficient when freeze-drying.
한편, 용매로 물을 사용할 경우 95 내지 105℃에서 230 내지 250분동안 가열할 수 있고, 유기용매를 사용할 경우 60 내지 85℃에서 3 내지 12시간동안 가열할 수 있으며, 바람직하게는 물을 사용할 경우 100℃에서 240분, 유기용매를 사용할 경우 80℃에서 4시간 동안 가열할 수 있다.On the other hand, when water is used as a solvent, it can be heated at 95 to 105°C for 230 to 250 minutes, and when an organic solvent is used, it can be heated at 60 to 85°C for 3 to 12 hours, preferably when water is used. It can be heated at 100℃ for 240 minutes, or when using an organic solvent, at 80℃ for 4 hours.
이때, 물을 사용할 때 온도가 95℃, 시간이 230분, 유기용매를 사용할 때 60℃, 3시간 미만이면 유효성분이 완전하게 추출되지 못할 수 있고, 물을 사용할 때 온도가 105℃, 시간이 250분, 유기용매를 사용할 때 85℃, 12시간을 초과하면 유효성분이 파괴될 수 있으며, 더 이상 추출되는 유효성분 수율이 더 증가하지 않으므로 더 이상의 추출은 의미가 없다.At this time, when using water, if the temperature is 95℃ and the time is 230 minutes, and when using an organic solvent, if the temperature is 60℃ and less than 3 hours, the active ingredient may not be completely extracted, and when using water, the temperature is 105℃ and the time is 250. If the temperature exceeds 12 hours at 85°C when using an organic solvent, the active ingredient may be destroyed, and the yield of the extracted active ingredient will not increase further, so further extraction is meaningless.
이와 같이 추출된 왕벚나무꽃 추출물, 복사나무꽃 추출물, 국화꽃 추출물을 배합하여 꽃 추출물이 제조될 수 있는데, 각 추출물을 바람직한 배합비로 혼합함으로써 상호작용으로 각 추출물을 단독으로 사용하는 것 보다 화장료 조성물의 피부장벽 및 염증 개선 효과가 향상 되도록 할 수 있다.A flower extract can be prepared by combining the extracted cherry blossom extract, prickly peach blossom extract, and chrysanthemum flower extract. By mixing each extract in a preferred mixing ratio, the cosmetic composition can be produced by interacting with each other rather than using each extract alone. The skin barrier and inflammation improvement effect can be improved.
즉, 꽃 추출물은 왕벚나무꽃 추출물, 복사나무꽃 추출물 및 국화꽃 추출물이 4.0 내지 4.8 : 0.4 내지 2 : 4.0 내지 4.8의 중량비로 혼합될 수 있으며, 4.5 : 1 : 4.5의 중량비로 혼합되는 것이 보다 바람직하다.That is, the flower extract may be a mixture of cherry blossom extract, prickly peach blossom extract, and chrysanthemum flower extract at a weight ratio of 4.0 to 4.8:0.4 to 2:4.0 to 4.8, and is more preferably mixed at a weight ratio of 4.5:1:4.5. desirable.
이러한 중량비로 포함될 경우에 가장 바람직한 피부장벽 및 염증 개선 효과를 나타낼 수 있다.When included in this weight ratio, it can exhibit the most desirable skin barrier and inflammation improvement effects.
또한, 꽃 추출물은 화장료 조성물 전체 중량에 대하여, 3 내지 10중량%가 함유될 수 있고, 3중량%가 가장 바람직하다.Additionally, the flower extract may be contained in an amount of 3 to 10% by weight, with 3% by weight being most preferred, based on the total weight of the cosmetic composition.
이때, 화장료 조성물 전체 중량에 대하여, 꽃 추출물이 3중량% 미만일 경우 효과가 미미하고, 10중량%를 초과할 경우 알레르기 반응, 따가움, 가려움 등을 발생시킬 수 있어 피부 안전성에 문제가 있을 수 있으며 관능적인 특성에 영향을 줄 수 있다.At this time, if the flower extract is less than 3% by weight relative to the total weight of the cosmetic composition, the effect is minimal, and if it exceeds 10% by weight, it may cause allergic reactions, stinging, itching, etc., which may cause problems with skin safety and sensory effects. may affect human characteristics.
이와 같은 꽃 추출물을 함유하는 화장료 조성물은 유액, 크림, 화장수, 에센스, 팩, 현탁액, 페이스트, 젤, 파우더, 립스틱, 메이컵 베이스, 파운데이션, 로션, 겔, 패취, 미용액, 클렌징 폼, 클렌징 크림, 클렌징 워터, 비누, 샴푸, 린스 및 분무제 중 하나의 제형으로 형성될 수 있으나, 이에 한정되지는 않는다.Cosmetic compositions containing such flower extracts include emulsions, creams, lotions, essences, packs, suspensions, pastes, gels, powders, lipsticks, makeup bases, foundations, lotions, gels, patches, serums, cleansing foams, cleansing creams, It may be formed in one of the following formulations: cleansing water, soap, shampoo, rinse, and spray, but is not limited thereto.
한편, 화장료 조성물은 꽃 추출물 외 참쑥 추출물을 더 포함할 수 있다.Meanwhile, the cosmetic composition may further include mugwort extract in addition to the flower extract.
참쑥 추출물은 보습효과와 진정 작용 등으로 민감한 부분을 효과적으로 진정시킬 수 있으며, 항균, 항염 작용을 나타낼 수 있다.Mugwort extract can effectively soothe sensitive areas through its moisturizing and soothing effects, and has antibacterial and anti-inflammatory effects.
이러한 참쑥 추출물은 참쑥으로부터 추출된 것으로, 상기에서 설명한 다른 추출물과 동일하게 추출될 수 있으므로, 자세한 설명은 생략하기로 한다. 여기서 사용되는 참쑥은 남원·지리산권 자원식물로, 남원시에서 채취하고 건조시켜 사용될 수 있는데, 35 내지 45℃에서 24시간 내지 72시간 건조한 것을 사용할 수 있고, 42℃에서 48시간 건조시킨 것을 사용하는 것이 바람직하다.This mugwort extract is extracted from mugwort and can be extracted in the same way as the other extracts described above, so detailed description will be omitted. The mugwort used here is a resource plant from the Namwon-Jiri Mountain area and can be collected and dried in Namwon City. It can be used dried at 35 to 45℃ for 24 to 72 hours, and it is preferable to use dried at 42℃ for 48 hours. do.
참쑥 추출물이 더 포함될 시, 화장료 조성물은 효능 측면을 고려하면 화장료 조성물 전체 중량에 대하여, 참쑥 추출물을 1 내지 2중량%로 함유할 수 있고, 1.5중량%가 가장 바람직하다.When the mugwort extract is further included, considering the efficacy aspect, the cosmetic composition may contain 1 to 2% by weight of the mugwort extract based on the total weight of the cosmetic composition, with 1.5% by weight being most preferable.
상기에서 설명한 바와 같이, 본 발명의 실시예에 따른 피부장벽 및 염증 개선 효과를 갖는 화장료 조성물은 왕벚나무꽃, 복사나무꽃 및 국화꽃으로부터 추출된 추출물을 포함하는 꽃 추출물을 함유함으로써, 보습 기능을 통해 각질층 손상을 방지하여 우수한 피부장벽 개선 효과를 가질 수 있다.As described above, the cosmetic composition having a skin barrier and inflammation improving effect according to an embodiment of the present invention contains a flower extract including extracts extracted from Yoshino cherry blossoms, prickly peach blossoms, and chrysanthemum flowers, thereby providing a moisturizing function. It can have an excellent skin barrier improvement effect by preventing damage to the stratum corneum.
또한 우수한 염증 개선 효과를 가질 수 있으며, 이에 홍조, 브라운색소, 색소침착 등을 개선시킬 수 있다.It can also have an excellent inflammation-improving effect, thereby improving redness, brown pigmentation, pigmentation, etc.
이하, 실시되는 실험 예들은 이해를 돕기 위하여 제시되는 것으로서, 본 발명을 예시하는 것일 뿐 본 발명의 권리범위가 하기 실험 예들에 한정되는 것은 아니다.The following experimental examples are presented to aid understanding, and are merely illustrative of the present invention, and the scope of the present invention is not limited to the following experimental examples.
또한, 하기에서 화장료 조성물의 효과를 알아보기 위해 용매로 물 및 에탄올을 사용하여 실시예 및 실험예를 설명하였으나, 실질적으로 화장료 조성물을 제조 시엔 1,3-부틸렌글리콜(1,3-butylene glycol)가 주로 사용될 수 있다.In addition, in order to investigate the effect of the cosmetic composition, examples and experimental examples are described below using water and ethanol as solvents. However, when actually manufacturing the cosmetic composition, 1,3-butylene glycol (1,3-butylene glycol) ) can be mainly used.
[제조예 1] 왕벚나무꽃 추출물 제조[Preparation Example 1] Preparation of Yoshino cherry blossom extract
남원·지리산권 자원식물인 왕벋나무꽃을 건조시키고, 건조시킨 왕벚나무꽃 5중량부에 대하여 95중량부의 50%에탄올을 첨가하고 80℃로 4시간 동안 가열한 후 농축시키고 동결건조하여 제조하였다.It was prepared by drying the cherry blossoms, a resource plant from the Namwon-Jiri Mountain area, adding 95 parts by weight of 50% ethanol to 5 parts by weight of the dried cherry blossoms, heating at 80°C for 4 hours, concentrating, and freeze-drying.
[제조예 2] 복사나무꽃 추출물 제조[Preparation Example 2] Preparation of peach tree flower extract
남원·지리산권 자원식물인 복사나무꽃을 건조시키고, 건조시킨 복사나무꽃 5중량부에 대하여 95중량부의 50%에탄올을 첨가하고 80℃로 4시간 동안 가열한 후 농축시키고 동결건조하여 제조하였다.It was prepared by drying peach blossoms, a resource plant from the Namwon-Jiri Mountain area, adding 95 parts by weight of 50% ethanol to 5 parts by weight of the dried peach blossoms, heating at 80°C for 4 hours, concentrating, and freeze-drying.
[제조예 3] 국화꽃 추출물 제조[Preparation Example 3] Preparation of chrysanthemum extract
남원·지리산권 자원식물인 국화꽃을 건조시키고, 건조시킨 국화꽃 5중량부에 대하여 95중량부의 50%에탄올을 첨가하고 80℃로 4시간 동안 가열한 후 농축시키고 동결건조하여 제조하였다.It was prepared by drying chrysanthemum flowers, a resource plant from the Namwon-Jiri Mountain area, adding 95 parts by weight of 50% ethanol to 5 parts by weight of the dried chrysanthemum flowers, heating at 80°C for 4 hours, concentrating, and freeze-drying.
[실시예] 꽃 추출물 제조[Example] Preparation of flower extract
제조예 1 내지 3을 표 1의 중량비와 같이 혼합하여 실시예 1 내지 4의 꽃 추출물을 제조하였다.Preparation Examples 1 to 3 were mixed according to the weight ratio in Table 1 to prepare flower extracts of Examples 1 to 4.
[실험예 1] 꽃 추출물 염증 개선 효과 평가[Experimental Example 1] Evaluation of the effect of flower extract on improving inflammation
꽃 추출물의 염증 개선 효과를 확인하기 위하여, 제조예 1 내지 3 및 실시예 1 내지 4의 추출물에 대해 NO 생성 억제능을 측정하여 염증 개선 효과를 평가하였다.In order to confirm the inflammation-improving effect of the flower extract, the NO production inhibitory ability of the extracts of Preparation Examples 1 to 3 and Examples 1 to 4 was measured to evaluate the inflammation-improving effect.
마우스 대식 세포 계열(murine macrophage cell line)인 RAW 264.7 cell을 한국세포주은행(KCLB; Seoul, Korea)으로부터 분양 받아 1% 페니실린-스트렙토마이신(penicillin-streptomycin)과 10% 소태아혈청(fetal bovine serum, FBS)이 함유된 DMEM 배지(dulbecco's modified eagle's medium, GIBCO, Grand Island, YY, USA)를 사용하여 37℃, 5% CO2 인큐베이터 조건에서 배양하였으며, 2일 간격으로 계대 배양을 시행하였다. 97 웰 플레이트(well plate)에 RAW 264.7 cells를 5Х104 cells/well로 분주하고 37℃, 5% CO2 인큐베이터 조건하에 24시간 배양한 후 실험에 사용하였다. 전 배양 후, 1 ㎍/㎖ LPS가 포함된 배지로 교환하여 시료를 첨가하여 24시간 배양하였다. RAW 264.7 cells, a murine macrophage cell line, were purchased from the Korea Cell Line Bank (KCLB; Seoul, Korea) and incubated with 1% penicillin-streptomycin and 10% fetal bovine serum. Cultured in DMEM medium (dulbecco's modified eagle's medium, GIBCO, Grand Island, YY, USA) containing FBS) at 37°C and 5% CO 2 incubator conditions, and subcultured at 2-day intervals. RAW 264.7 cells were dispensed at 5Х10 4 cells/well in a 97 well plate and cultured for 24 hours at 37°C and 5% CO 2 incubator conditions before being used in the experiment. After pre-culture, the medium was replaced with 1 ㎍/㎖ LPS, the sample was added, and cultured for 24 hours.
생성된 NO의 양은 Griess 시약(1% sulfanilamide, 0.1% naphylethylenediamine in 2.5% phosphoric acid)을 이용하여 세포배양액 중에서 존재하는 NO2 -의 형태로 측정하였다. 세포배양 상등액 100 ㎕와 Griess 시약 100 ㎕를 혼합하여 96 well plate에서 10분 동안 반응시킨 후 540 ㎚에서 흡광도를 측정하였다. 생성된 NO의 양은 아질산나트륨(sodium nitrite, NaNO2)를 이용하여 검정곡선을 작성하여 비교하였다.The amount of NO produced was measured in the form of NO 2 - present in the cell culture medium using Griess reagent (1% sulfanilamide, 0.1% naphylethylenediamine in 2.5% phosphoric acid). 100 ㎕ of cell culture supernatant and 100 ㎕ of Griess reagent were mixed and reacted for 10 minutes in a 96 well plate, and then the absorbance was measured at 540 ㎚. The amount of NO produced was compared by creating a calibration curve using sodium nitrite (NaNO 2 ).
그 결과는 하기 표 2 및 도 1과 같다.The results are shown in Table 2 and Figure 1 below.
표 2와 도 1에 나타난 바와 같이, 실시예 1 내지 4가 단독 추출물인 제조예 1 내지 3 보다 NO 생성이 적게 나타나는 것을 확인할 수 있었다.또한 실시예 1 내지 4에서도 특히 실시예 2에서 NO 생성이 가장 낮게 나타나는 것을 확인할 수 있었다.As shown in Table 2 and Figure 1, it was confirmed that Examples 1 to 4 produced less NO than Preparation Examples 1 to 3, which were single extracts. Also, in Examples 1 to 4, especially in Example 2, NO production was observed. It was confirmed that it appeared at the lowest level.
이를 통해 단독 추출물 보다 추출물을 혼합한 꽃 추출물의 염증 개선 효과가 우수하며, 왕벚나무꽃 추출물, 복사나무꽃 추출물 및 국화꽃 추출물이 4.5 : 1 : 4.5의 중량비로 혼합될 경우 가장 우수한 염증 개선 효과를 나타내는 것으로 사료되었다.Through this, the inflammation-improving effect of flower extracts mixed with extracts is superior to that of individual extracts, and the best inflammation-improving effect is achieved when Yoshino cherry blossom extract, prickly peach blossom extract, and chrysanthemum flower extract are mixed at a weight ratio of 4.5:1:4.5. It was thought to represent.
[제조예 4] 왕벚나무꽃 추출물 제조[Preparation Example 4] Preparation of Yoshino cherry blossom extract
남원·지리산권 자원식물인 왕벚나무꽃을 건조시키고, 건조시킨 왕벚나무꽃 5중량부에 대하여 95중량부의 40%부틸렌글라이콜을 첨가하고 60℃로 24시간 동안 환류추출하여 제조하였다.It was prepared by drying Yoshino cherry blossoms, a resource plant in the Namwon-Jiri Mountain area, adding 95 parts by weight of 40% butylene glycol to 5 parts by weight of dried Yoshino cherry blossoms, and extracting by refluxing at 60°C for 24 hours.
[제조예 5] 복사나무꽃 추출물 제조[Preparation Example 5] Preparation of peach tree flower extract
남원·지리산권 자원식물인 복사나무꽃을 건조시키고, 건조시킨 복사나무꽃 5중량부에 대하여 95중량부의 40%부틸렌글라이콜을 첨가하고 60℃로 24시간 동안 환류추출하여 제조하였다.It was prepared by drying peach blossoms, a resource plant in the Namwon-Jiri Mountain area, adding 95 parts by weight of 40% butylene glycol to 5 parts by weight of the dried peach blossoms, and extracting by refluxing at 60°C for 24 hours.
[제조예 6] 국화꽃 추출물 제조[Preparation Example 6] Preparation of chrysanthemum extract
남원·지리산권 자원식물인 국화꽃을 건조시키고, 건조시킨 국화꽃 5중량부에 대하여 95중량부의 40%부틸렌글라이콜을 첨가하고 60℃로 24시간 동안 환류추출하여 제조하였다.It was prepared by drying chrysanthemum flowers, a resource plant in the Namwon-Jiri Mountain area, adding 95 parts by weight of 40% butylene glycol to 5 parts by weight of the dried chrysanthemum flowers, and extracting by refluxing at 60°C for 24 hours.
[제형예] 꽃 추출물을 함유하는 화장료 제조[Formulation example] Manufacturing cosmetics containing flower extracts
가장 우수한 염증개선 효과를 나타내는 실시예 2의 꽃 추출물과 동일한 비율로 제조예 4 내지 6을 이용하여 꽃 추출물을 제조한 후, 하기 표 3과 같이 화장료 조성물을 구성하여 제조하였다.A flower extract was prepared using Preparation Examples 4 to 6 in the same ratio as the flower extract of Example 2, which showed the best inflammation-improving effect, and then a cosmetic composition was prepared as shown in Table 3 below.
여기서 사용된 꽃 추출물은 제조예 4 내지 6이 4.5 : 1 : 4.5의 중량비로 혼합되어 제조된 것이다.The flower extract used here was prepared by mixing Preparation Examples 4 to 6 at a weight ratio of 4.5:1:4.5.
[실험예 2] 효능 평가[Experimental Example 2] Efficacy evaluation
꽃 추출물을 함유하는 화장료 조성물의 효능을 확인하기 위하여, 선정기준에 부합하고 제외기준에 해당되지 않는 피시험자 12명(평균연령 33.3세)을 선별하여, 화장료 조성물을 안면부에 도포하는 것으로 사용하게 한 후, 수분 개선 효과, 피부장벽 개선 효과, 홍조 개선 효과, 브라운색소 개선 효과, 색소침착 개선 효과에 대하여 평가하였다.In order to confirm the efficacy of a cosmetic composition containing flower extract, 12 test subjects (average age 33.3 years) who met the selection criteria and did not meet the exclusion criteria were selected and used by applying the cosmetic composition to the facial area. Afterwards, the moisture improvement effect, skin barrier improvement effect, redness improvement effect, brown pigment improvement effect, and pigmentation improvement effect were evaluated.
이때, 피시험자들은 특별한 피부 증상이 없었고, 시험에 영향을 줄 수 있는 질환 및 약물 복용도 하지 않았다.At this time, the test subjects had no special skin symptoms and did not have any diseases or medications that could affect the test.
실험은 4주간 진행하였고, 각 항목에 대하여 사용 전에 측정 한 후, 주마다 상태를 측정하였다. The experiment was conducted for 4 weeks, and each item was measured before use, and the condition was measured every week.
수분 개선 효과는 Skin-O-Mat를 이용하여 시험부위를 3회 측정하여 각질층 수분 함량을 측정하였고, 피부장벽 개선 효과는 AquaFlux를 이용하여 시험부위를 1회 측정하여 경피수분손실량을 측정하였으며, 브라운색소, 홍조, 색소침착 개선 효과는 각각 Mark.Vu를 이용하여 시험부위를 1회 촬영하는 것으로 측정하였다.For the moisture improvement effect, the moisture content of the stratum corneum was measured by measuring the test area three times using Skin-O-Mat. For the skin barrier improvement effect, the transepidermal moisture loss was measured by measuring the test area once using AquaFlux. Brown The effect of improving pigmentation, redness, and pigmentation was measured by photographing the test area once using Mark.Vu.
그 결과는 도 2 내지 6과 같다.The results are shown in Figures 2 to 6.
1) 수분 개선 효과 확인1) Check the moisture improvement effect
도 2의 (a) 및 (b)는 화장료 조성물 사용 전/사용 후에 따른 각질층 수분 함량과 수분 개선율을 나타낸 그래프이다.Figures 2 (a) and (b) are graphs showing the moisture content of the stratum corneum and moisture improvement rate before and after use of the cosmetic composition.
도 2에 나타난 바와 같이, 각질층 수분함량을 측정하여 개선율을 확인해보면, 개인차는 조금씩 있었으나 평균적으로 사용 전과 비교하여 사용 4주 후 5.32%의 개선율을 보이는 것을 확인할 수 있었다. As shown in Figure 2, when the moisture content of the stratum corneum was measured to check the improvement rate, it was confirmed that there were slight individual differences, but on average, an improvement rate of 5.32% was seen after 4 weeks of use compared to before use.
2) 피부장벽 개선 효과 확인2) Confirmation of skin barrier improvement effect
도 3의 (a) 및 (b)는 화장료 조성물 사용 전/ 사용 후에 따른 경피 수분 손실량 및 피부장벽 개선율을 나타낸 그래프이다.Figures 3 (a) and (b) are graphs showing the transdermal moisture loss and skin barrier improvement rate before and after use of the cosmetic composition.
도 3에 나타난 바와 같이, 화장료 조성물을 사용한 후 경피 수분의 손실량이 감소하였고, 개인차는 조금씩 있었으나 평균적으로 사용 전과 비교하여 사용 3주 후, 사용 4주 후 각각 18.55%, 15.18%의 개선율을 보이는 것을 확인할 수 있었다.As shown in Figure 3, the amount of transdermal water loss decreased after using the cosmetic composition, and although there were slight individual differences, on average, improvement rates of 18.55% and 15.18% were shown after 3 weeks and 4 weeks of use, respectively, compared to before use. I was able to confirm.
3) 홍조 개선 효과 확인3) Confirmation of redness improvement effect
도 4의 (a) 및 (b)는 화장료 조성물 사용 전/사용 후에 따른 홍조 면적당 백분율 및 홍조 개선율을 나타낸 그래프이다.Figures 4 (a) and (b) are graphs showing the percentage per flushing area and the improvement rate of flushing before and after using the cosmetic composition.
도 4에 나타난 바와 같이, 화장료 조성물 사용 후 홍조 분포 면적이 감소된 것을 확인할 수 있었고, 개인차는 조금씩 있었으나 평균적으로 사용 전과 비교하여 사용 4주 후 12.5%의 개선율을 보이는 것을 확인할 수 있었다.As shown in Figure 4, it was confirmed that the area of redness distribution was reduced after using the cosmetic composition, and although there were some individual differences, on average, it was confirmed that an improvement rate of 12.5% was seen after 4 weeks of use compared to before use.
4) 브라운색소 개선 효과 확인4) Check the effect of improving brown pigmentation
도 5의 (a) 및 (b)는 화장료 조성물 사용 전/사용 후에 따른 브라운 색소 면적당 백분율 및 브라운색소 개선율을 나타낸 그래프이다.Figures 5 (a) and (b) are graphs showing the percentage per area of brown pigment and the improvement rate of brown pigment before and after use of the cosmetic composition.
도 5에 나타난 바와 같이, 화장료 조성물 사용 후 브라운색소 분포 면적이 감소된 것을 확인할 수 있었고, 개인차는 조금씩 있었으나 평균적으로 사용 전과 비교하여 사용 3주 후 11.84%, 사용 4주 후 12.5%의 개선율을 보이는 것을 확인할 수 있었다.As shown in Figure 5, it was confirmed that the brown pigment distribution area was reduced after using the cosmetic composition, and although there were some individual differences, on average, an improvement rate of 11.84% after 3 weeks of use and 12.5% after 4 weeks of use compared to before use was observed. could be confirmed.
5) 색소침착 개선 효과 확인5) Confirm the effect of improving pigmentation
도 6의 (a) 및 (b)는 화장료 조성물 사용 전/사용 후에 따른 색소침착 면적당 백분율 및 색소침착 개선율을 나타낸 그래프이다.Figures 6 (a) and (b) are graphs showing the percentage per area of pigmentation and the improvement rate of pigmentation before and after use of the cosmetic composition.
도 6에 나타난 바와 같이, 화장료 조성물 사용 후 색소침착 분포 면적이 감소된 것을 확인할 수 있었고, 개인차는 조금씩 있었으나 평균적으로 사용 전과 비교하여 사용 4주 후 10.6%의 개선율을 보이는 것을 확인할 수 있었다.As shown in Figure 6, it was confirmed that the pigmentation distribution area was reduced after using the cosmetic composition, and although there were some individual differences, on average, it was confirmed that an improvement rate of 10.6% was seen after 4 weeks of use compared to before use.
이상으로 첨부된 도면을 참조하여 본 발명의 실시예를 설명하였으나, 본 발명이 속하는 기술분야에서 통상의 지식을 가진 자는 본 발명의 기술적 사상이나 필수적인 특징을 변경하지 않고 다른 구체적인 형태로 실시할 수 있다는 것을 이해할 수 있을 것이다. 따라서 이상에서 기술한 실시예는 모든 면에서 예시적인 것이며 한정적이 아닌 것이다.Although embodiments of the present invention have been described above with reference to the attached drawings, those skilled in the art can realize that the present invention can be implemented in other specific forms without changing the technical idea or essential features of the present invention. You will be able to understand it. Therefore, the embodiments described above are illustrative in all respects and are not restrictive.
Claims (4)
상기 꽃 추출물은,
상기 화장료 조성물 전체 중량에 대하여, 3 내지 5중량%로 함유되는 것을 특징으로 하는 피부장벽 및 염증 개선 효과를 갖는 화장료 조성물.
Contains a flower extract including cherry blossom extract, prickly peach blossom extract, and chrysanthemum flower extract in a weight ratio of 4.0 to 4.75:0.5 to 2:4 to 4.75,
The flower extract is,
A cosmetic composition having a skin barrier and inflammation improving effect, characterized in that it is contained in an amount of 3 to 5% by weight based on the total weight of the cosmetic composition.
상기 왕벚나무꽃 추출물, 복사나무꽃 추출물 및 국화꽃 추출물은,
왕벚나무꽃, 복사나무꽃, 국화꽃을 각각 물 또는 유기용매의 용매로 추출한 것을 특징으로 하는 피부장벽 및 염증 개선 효과를 갖는 화장료 조성물.
According to paragraph 1,
The above cherry blossom extract, prickly peach blossom extract, and chrysanthemum flower extract,
A cosmetic composition with skin barrier and inflammation improvement effects, characterized by extracting cherry blossoms, peach blossoms, and chrysanthemum flowers with water or an organic solvent, respectively.
유액, 크림, 화장수, 에센스, 팩, 현탁액, 페이스트, 젤, 파우더, 립스틱, 메이컵 베이스, 파운데이션, 로션, 겔, 패취, 미용액, 클렌징 폼, 클렌징 크림, 클렌징 워터, 비누, 샴푸, 린스 및 분무제 중 하나의 제형인 것을 특징으로 하는 피부장벽 및 염증 개선 효과를 갖는 화장료 조성물.According to paragraph 1,
Emulsion, cream, lotion, essence, pack, suspension, paste, gel, powder, lipstick, makeup base, foundation, lotion, gel, patch, serum, cleansing foam, cleansing cream, cleansing water, soap, shampoo, rinse and spray. A cosmetic composition having a skin barrier and inflammation improving effect, characterized in that it is one of the formulations.
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| KR1020230099682A KR102641319B1 (en) | 2021-07-28 | 2023-07-31 | Cosmetic composition having an effect of improving skin barrier and inflammation |
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| KR1020210099502A KR20230017683A (en) | 2021-07-28 | 2021-07-28 | Cosmetic composition having an effect of improving skin barrier and inflammation |
| KR1020230099682A KR102641319B1 (en) | 2021-07-28 | 2023-07-31 | Cosmetic composition having an effect of improving skin barrier and inflammation |
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| KR20230117091A KR20230117091A (en) | 2023-08-07 |
| KR102641319B1 true KR102641319B1 (en) | 2024-02-27 |
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| KR1020230099682A KR102641319B1 (en) | 2021-07-28 | 2023-07-31 | Cosmetic composition having an effect of improving skin barrier and inflammation |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009001514A (en) | 2007-06-20 | 2009-01-08 | Yoshihiro Futamura | Anethole derivative having inflammatory cytokine production-inhibiting action, and food preparation, cosmetic and antiinflammatory agent comprising the same |
| JP2013512235A (en) * | 2009-11-27 | 2013-04-11 | ウンジン コーウェイ カンパニー リミテッド | Nochiku extract or composition having anti-inflammatory activity containing this fraction |
| KR102250462B1 (en) | 2020-02-12 | 2021-05-11 | 재단법인 남원시화장품산업지원센터 | Multifunctional cosmetic composition containing a flower extract |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102348698B1 (en) * | 2019-08-22 | 2022-01-06 | 재단법인 남원시화장품산업지원센터 | Antioxidant and moisturizing cosmetic composition containing mixed extracts including Prunus yedoensis flower, Peach tree flower and Chrysanthemum flower extract |
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- 2021-07-28 KR KR1020210099502A patent/KR20230017683A/en active Application Filing
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- 2023-07-31 KR KR1020230099682A patent/KR102641319B1/en active IP Right Grant
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009001514A (en) | 2007-06-20 | 2009-01-08 | Yoshihiro Futamura | Anethole derivative having inflammatory cytokine production-inhibiting action, and food preparation, cosmetic and antiinflammatory agent comprising the same |
| JP2013512235A (en) * | 2009-11-27 | 2013-04-11 | ウンジン コーウェイ カンパニー リミテッド | Nochiku extract or composition having anti-inflammatory activity containing this fraction |
| KR102250462B1 (en) | 2020-02-12 | 2021-05-11 | 재단법인 남원시화장품산업지원센터 | Multifunctional cosmetic composition containing a flower extract |
Non-Patent Citations (1)
| Title |
|---|
| 이태범 외 3명. 화장품 소재로서의 꽃 10 종 에탄올추출물 생리활성 특성연구. 한국약용작물학회지, 2020 |
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| KR20230117091A (en) | 2023-08-07 |
| KR20230017683A (en) | 2023-02-06 |
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