KR102622690B1 - Cosmetic composition for protecting skin comprising mixed extracts of acer tegmentosum and magnolia sieboldii as active ingredient - Google Patents
Cosmetic composition for protecting skin comprising mixed extracts of acer tegmentosum and magnolia sieboldii as active ingredient Download PDFInfo
- Publication number
- KR102622690B1 KR102622690B1 KR1020210135722A KR20210135722A KR102622690B1 KR 102622690 B1 KR102622690 B1 KR 102622690B1 KR 1020210135722 A KR1020210135722 A KR 1020210135722A KR 20210135722 A KR20210135722 A KR 20210135722A KR 102622690 B1 KR102622690 B1 KR 102622690B1
- Authority
- KR
- South Korea
- Prior art keywords
- cosmetic composition
- dandruff
- extract
- acne
- mixed
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 87
- 239000000284 extract Substances 0.000 title claims abstract description 84
- 239000002537 cosmetic Substances 0.000 title claims abstract description 52
- 241000580937 Acer tegmentosum Species 0.000 title claims abstract description 12
- 241001673954 Magnolia sieboldii Species 0.000 title claims abstract description 12
- 239000004480 active ingredient Substances 0.000 title claims abstract description 11
- 206010000496 acne Diseases 0.000 claims abstract description 35
- 210000002374 sebum Anatomy 0.000 claims abstract description 34
- 208000002874 Acne Vulgaris Diseases 0.000 claims abstract description 33
- 208000001840 Dandruff Diseases 0.000 claims abstract description 22
- 230000028327 secretion Effects 0.000 claims abstract description 18
- 241000894006 Bacteria Species 0.000 claims abstract description 12
- 230000000844 anti-bacterial effect Effects 0.000 claims abstract description 10
- 241000191967 Staphylococcus aureus Species 0.000 claims abstract description 5
- 238000009472 formulation Methods 0.000 claims description 44
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 31
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 21
- 235000004652 Tilia americana var heterophylla Nutrition 0.000 claims description 17
- 241001473881 Tilia caroliniana subsp. heterophylla Species 0.000 claims description 17
- 230000000694 effects Effects 0.000 claims description 16
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims description 15
- 239000002904 solvent Substances 0.000 claims description 14
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 12
- 238000000605 extraction Methods 0.000 claims description 12
- 238000000034 method Methods 0.000 claims description 12
- 239000006071 cream Substances 0.000 claims description 11
- 239000000843 powder Substances 0.000 claims description 10
- 239000000344 soap Substances 0.000 claims description 9
- 239000006210 lotion Substances 0.000 claims description 8
- 239000000839 emulsion Substances 0.000 claims description 7
- 239000000243 solution Substances 0.000 claims description 6
- 239000007921 spray Substances 0.000 claims description 6
- 239000004094 surface-active agent Substances 0.000 claims description 6
- 239000000499 gel Substances 0.000 claims description 5
- 239000003921 oil Substances 0.000 claims description 5
- DKPFZGUDAPQIHT-UHFFFAOYSA-N Butyl acetate Natural products CCCCOC(C)=O DKPFZGUDAPQIHT-UHFFFAOYSA-N 0.000 claims description 4
- 125000004432 carbon atom Chemical group C* 0.000 claims description 4
- FUZZWVXGSFPDMH-UHFFFAOYSA-N hexanoic acid Chemical compound CCCCCC(O)=O FUZZWVXGSFPDMH-UHFFFAOYSA-N 0.000 claims description 4
- 239000006072 paste Substances 0.000 claims description 4
- 239000000725 suspension Substances 0.000 claims description 4
- 239000003599 detergent Substances 0.000 claims description 3
- 238000002360 preparation method Methods 0.000 description 27
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 description 16
- 238000004519 manufacturing process Methods 0.000 description 13
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 12
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 12
- -1 pack Substances 0.000 description 12
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 10
- 210000003491 skin Anatomy 0.000 description 10
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 9
- 239000000686 essence Substances 0.000 description 9
- 239000003205 fragrance Substances 0.000 description 9
- POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Natural products NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 description 8
- 229920002535 Polyethylene Glycol 1500 Polymers 0.000 description 8
- 229920002385 Sodium hyaluronate Polymers 0.000 description 8
- 229960000458 allantoin Drugs 0.000 description 8
- 238000004040 coloring Methods 0.000 description 8
- 239000012153 distilled water Substances 0.000 description 8
- 239000004615 ingredient Substances 0.000 description 8
- 230000005764 inhibitory process Effects 0.000 description 8
- 239000003755 preservative agent Substances 0.000 description 8
- 229940010747 sodium hyaluronate Drugs 0.000 description 8
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 description 8
- VUYXVWGKCKTUMF-UHFFFAOYSA-N tetratriacontaethylene glycol monomethyl ether Chemical compound COCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO VUYXVWGKCKTUMF-UHFFFAOYSA-N 0.000 description 8
- 229940079894 benzophenone-9 Drugs 0.000 description 7
- 230000015572 biosynthetic process Effects 0.000 description 7
- 230000000052 comparative effect Effects 0.000 description 7
- QDCHWIWENYCPIL-UHFFFAOYSA-L disodium;4-hydroxy-5-(2-hydroxy-4-methoxy-5-sulfonatobenzoyl)-2-methoxybenzenesulfonate Chemical compound [Na+].[Na+].C1=C(S([O-])(=O)=O)C(OC)=CC(O)=C1C(=O)C1=CC(S([O-])(=O)=O)=C(OC)C=C1O QDCHWIWENYCPIL-UHFFFAOYSA-L 0.000 description 7
- 229940088597 hormone Drugs 0.000 description 7
- 239000005556 hormone Substances 0.000 description 7
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 6
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 6
- 108090000790 Enzymes Proteins 0.000 description 6
- 102000004190 Enzymes Human genes 0.000 description 6
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 6
- 230000009036 growth inhibition Effects 0.000 description 6
- 210000003780 hair follicle Anatomy 0.000 description 6
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 6
- 210000001732 sebaceous gland Anatomy 0.000 description 6
- 241000723353 Chrysanthemum Species 0.000 description 5
- 235000007516 Chrysanthemum Nutrition 0.000 description 5
- 241000186427 Cutibacterium acnes Species 0.000 description 5
- 241000555688 Malassezia furfur Species 0.000 description 5
- 235000012000 cholesterol Nutrition 0.000 description 5
- 235000014113 dietary fatty acids Nutrition 0.000 description 5
- 239000000194 fatty acid Substances 0.000 description 5
- 229930195729 fatty acid Natural products 0.000 description 5
- LEACJMVNYZDSKR-UHFFFAOYSA-N 2-octyldodecan-1-ol Chemical compound CCCCCCCCCCC(CO)CCCCCCCC LEACJMVNYZDSKR-UHFFFAOYSA-N 0.000 description 4
- KWIUHFFTVRNATP-UHFFFAOYSA-N Betaine Natural products C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 description 4
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 4
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 description 4
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 4
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 4
- KWIUHFFTVRNATP-UHFFFAOYSA-O N,N,N-trimethylglycinium Chemical compound C[N+](C)(C)CC(O)=O KWIUHFFTVRNATP-UHFFFAOYSA-O 0.000 description 4
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 4
- VCUFZILGIRCDQQ-KRWDZBQOSA-N N-[[(5S)-2-oxo-3-(2-oxo-3H-1,3-benzoxazol-6-yl)-1,3-oxazolidin-5-yl]methyl]-2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carboxamide Chemical compound O=C1O[C@H](CN1C1=CC2=C(NC(O2)=O)C=C1)CNC(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F VCUFZILGIRCDQQ-KRWDZBQOSA-N 0.000 description 4
- 229920001213 Polysorbate 20 Polymers 0.000 description 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 4
- 229920002125 Sokalan® Polymers 0.000 description 4
- MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 description 4
- BTFJIXJJCSYFAL-UHFFFAOYSA-N arachidyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCO BTFJIXJJCSYFAL-UHFFFAOYSA-N 0.000 description 4
- 229960003237 betaine Drugs 0.000 description 4
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 4
- 150000002632 lipids Chemical class 0.000 description 4
- 235000019198 oils Nutrition 0.000 description 4
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 4
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 4
- 229940068977 polysorbate 20 Drugs 0.000 description 4
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 3
- NVKAWKQGWWIWPM-ABEVXSGRSA-N 17-β-hydroxy-5-α-Androstan-3-one Chemical compound C1C(=O)CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CC[C@H]21 NVKAWKQGWWIWPM-ABEVXSGRSA-N 0.000 description 3
- 102100022089 Acyl-[acyl-carrier-protein] hydrolase Human genes 0.000 description 3
- 241000218691 Cupressaceae Species 0.000 description 3
- 201000004624 Dermatitis Diseases 0.000 description 3
- 206010061218 Inflammation Diseases 0.000 description 3
- 150000001298 alcohols Chemical class 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 3
- 238000000855 fermentation Methods 0.000 description 3
- 230000004151 fermentation Effects 0.000 description 3
- 235000011187 glycerol Nutrition 0.000 description 3
- 230000004054 inflammatory process Effects 0.000 description 3
- 230000007794 irritation Effects 0.000 description 3
- 238000005259 measurement Methods 0.000 description 3
- 244000005700 microbiome Species 0.000 description 3
- 238000002156 mixing Methods 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 238000011160 research Methods 0.000 description 3
- 238000000926 separation method Methods 0.000 description 3
- 238000003786 synthesis reaction Methods 0.000 description 3
- 238000005406 washing Methods 0.000 description 3
- 239000001993 wax Substances 0.000 description 3
- DNIAPMSPPWPWGF-GSVOUGTGSA-N (R)-(-)-Propylene glycol Chemical compound C[C@@H](O)CO DNIAPMSPPWPWGF-GSVOUGTGSA-N 0.000 description 2
- 108010066551 Cholestenone 5 alpha-Reductase Proteins 0.000 description 2
- LCGLNKUTAGEVQW-UHFFFAOYSA-N Dimethyl ether Chemical compound COC LCGLNKUTAGEVQW-UHFFFAOYSA-N 0.000 description 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
- 108010016731 PPAR gamma Proteins 0.000 description 2
- 102100038825 Peroxisome proliferator-activated receptor gamma Human genes 0.000 description 2
- 239000002202 Polyethylene glycol Substances 0.000 description 2
- ATUOYWHBWRKTHZ-UHFFFAOYSA-N Propane Chemical compound CCC ATUOYWHBWRKTHZ-UHFFFAOYSA-N 0.000 description 2
- 108010074436 Sterol Regulatory Element Binding Protein 1 Proteins 0.000 description 2
- 102100026839 Sterol regulatory element-binding protein 1 Human genes 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 2
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 description 2
- 239000003098 androgen Substances 0.000 description 2
- 229940030486 androgens Drugs 0.000 description 2
- 229960003473 androstanolone Drugs 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 239000000440 bentonite Substances 0.000 description 2
- 229910000278 bentonite Inorganic materials 0.000 description 2
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 2
- SESFRYSPDFLNCH-UHFFFAOYSA-N benzyl benzoate Chemical compound C=1C=CC=CC=1C(=O)OCC1=CC=CC=C1 SESFRYSPDFLNCH-UHFFFAOYSA-N 0.000 description 2
- 239000001569 carbon dioxide Substances 0.000 description 2
- 229910002092 carbon dioxide Inorganic materials 0.000 description 2
- 239000001913 cellulose Substances 0.000 description 2
- 229920002678 cellulose Polymers 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 239000012141 concentrate Substances 0.000 description 2
- 238000002828 disc diffusion antibiotic sensitivity testing Methods 0.000 description 2
- SNPLKNRPJHDVJA-UHFFFAOYSA-N dl-panthenol Chemical compound OCC(C)(C)C(O)C(=O)NCCCO SNPLKNRPJHDVJA-UHFFFAOYSA-N 0.000 description 2
- RLGKNOKKEQLVIU-UHFFFAOYSA-N ethanol Chemical compound CCO.CCO.CCO.CCO RLGKNOKKEQLVIU-UHFFFAOYSA-N 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 150000004665 fatty acids Chemical class 0.000 description 2
- 239000006260 foam Substances 0.000 description 2
- 235000021588 free fatty acids Nutrition 0.000 description 2
- 230000014509 gene expression Effects 0.000 description 2
- 230000012010 growth Effects 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 239000003112 inhibitor Substances 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 230000003902 lesion Effects 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000002609 medium Substances 0.000 description 2
- 238000009629 microbiological culture Methods 0.000 description 2
- YBYRMVIVWMBXKQ-UHFFFAOYSA-N phenylmethanesulfonyl fluoride Chemical compound FS(=O)(=O)CC1=CC=CC=C1 YBYRMVIVWMBXKQ-UHFFFAOYSA-N 0.000 description 2
- 229920001223 polyethylene glycol Polymers 0.000 description 2
- 239000011148 porous material Substances 0.000 description 2
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 238000000746 purification Methods 0.000 description 2
- 238000010992 reflux Methods 0.000 description 2
- 239000000377 silicon dioxide Substances 0.000 description 2
- 238000000638 solvent extraction Methods 0.000 description 2
- 239000012086 standard solution Substances 0.000 description 2
- 238000000194 supercritical-fluid extraction Methods 0.000 description 2
- 239000000454 talc Substances 0.000 description 2
- 229910052623 talc Inorganic materials 0.000 description 2
- 229960003604 testosterone Drugs 0.000 description 2
- JYKSTGLAIMQDRA-UHFFFAOYSA-N tetraglycerol Chemical compound OCC(O)CO.OCC(O)CO.OCC(O)CO.OCC(O)CO JYKSTGLAIMQDRA-UHFFFAOYSA-N 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 238000002137 ultrasound extraction Methods 0.000 description 2
- 235000015112 vegetable and seed oil Nutrition 0.000 description 2
- 239000008158 vegetable oil Substances 0.000 description 2
- JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical compound OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 description 1
- 229940058015 1,3-butylene glycol Drugs 0.000 description 1
- WNWHHMBRJJOGFJ-UHFFFAOYSA-N 16-methylheptadecan-1-ol Chemical class CC(C)CCCCCCCCCCCCCCCO WNWHHMBRJJOGFJ-UHFFFAOYSA-N 0.000 description 1
- AFRGVXOQPDKXRT-UHFFFAOYSA-N 2-[bis(2-hydroxyethyl)amino]ethanol Chemical compound OCCN(CCO)CCO.OCCN(CCO)CCO.OCCN(CCO)CCO AFRGVXOQPDKXRT-UHFFFAOYSA-N 0.000 description 1
- 239000002677 5-alpha reductase inhibitor Substances 0.000 description 1
- 102000004146 ATP citrate synthases Human genes 0.000 description 1
- 108090000662 ATP citrate synthases Proteins 0.000 description 1
- 241000795489 Abutilon angulatum Species 0.000 description 1
- 241000208140 Acer Species 0.000 description 1
- 102000000452 Acetyl-CoA carboxylase Human genes 0.000 description 1
- 108010016219 Acetyl-CoA carboxylase Proteins 0.000 description 1
- 208000020154 Acnes Diseases 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- 241000256844 Apis mellifera Species 0.000 description 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 1
- 206010004446 Benign prostatic hyperplasia Diseases 0.000 description 1
- 108010018763 Biotin carboxylase Proteins 0.000 description 1
- 101000964894 Bos taurus 14-3-3 protein zeta/delta Proteins 0.000 description 1
- 241000675108 Citrus tangerina Species 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
- 238000002965 ELISA Methods 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 108010039731 Fatty Acid Synthases Proteins 0.000 description 1
- 235000011201 Ginkgo Nutrition 0.000 description 1
- 244000194101 Ginkgo biloba Species 0.000 description 1
- 235000008100 Ginkgo biloba Nutrition 0.000 description 1
- 101000824278 Homo sapiens Acyl-[acyl-carrier-protein] hydrolase Proteins 0.000 description 1
- 101000611023 Homo sapiens Tumor necrosis factor receptor superfamily member 6 Proteins 0.000 description 1
- 239000009141 Houttuynia cordata plant extract Substances 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 239000004166 Lanolin Substances 0.000 description 1
- BNMGUJRJUUDLHW-HCZMHFOYSA-N Madecassoside Chemical compound O([C@@H]1[C@@H](CO)O[C@H]([C@@H]([C@H]1O)O)OC[C@H]1O[C@H]([C@@H]([C@@H](O)[C@@H]1O)O)OC(=O)[C@]12CC[C@H]([C@@H]([C@H]1C=1[C@@]([C@@]3(C[C@@H](O)[C@H]4[C@](C)(CO)[C@@H](O)[C@H](O)C[C@]4(C)[C@H]3CC=1)C)(C)CC2)C)C)[C@@H]1O[C@@H](C)[C@H](O)[C@@H](O)[C@H]1O BNMGUJRJUUDLHW-HCZMHFOYSA-N 0.000 description 1
- BNMGUJRJUUDLHW-HLUHVYOBSA-N Madecassoside Natural products C[C@@H]1CC[C@@]2(CC[C@]3(C)C(=CC[C@@H]4[C@@]5(C)C[C@@H](O)[C@H](O)[C@@](C)(CO)[C@@H]5[C@H](O)C[C@@]34C)[C@@H]2[C@H]1C)C(=O)O[C@@H]6O[C@H](CO[C@@H]7O[C@H](CO)[C@@H](O[C@@H]8O[C@H](C)[C@H](O)[C@@H](O)[C@H]8O)[C@H](O)[C@H]7O)[C@@H](O)[C@H](O)[C@H]6O BNMGUJRJUUDLHW-HLUHVYOBSA-N 0.000 description 1
- 241000218377 Magnoliaceae Species 0.000 description 1
- ACFIXJIJDZMPPO-NNYOXOHSSA-N NADPH Chemical compound C1=CCC(C(=O)N)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2[C@H]([C@@H](OP(O)(O)=O)[C@@H](O2)N2C3=NC=NC(N)=C3N=C2)O)O1 ACFIXJIJDZMPPO-NNYOXOHSSA-N 0.000 description 1
- 244000265736 Nelumbo pentapetala Species 0.000 description 1
- 235000006510 Nelumbo pentapetala Nutrition 0.000 description 1
- 208000012868 Overgrowth Diseases 0.000 description 1
- 241000255969 Pieris brassicae Species 0.000 description 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
- 239000004952 Polyamide Substances 0.000 description 1
- 108010039918 Polylysine Proteins 0.000 description 1
- 208000004403 Prostatic Hyperplasia Diseases 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- 206010040867 Skin hypertrophy Diseases 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 108010020396 Sterol Regulatory Element Binding Proteins Proteins 0.000 description 1
- 102000009822 Sterol Regulatory Element Binding Proteins Human genes 0.000 description 1
- ULUAUXLGCMPNKK-UHFFFAOYSA-N Sulfobutanedioic acid Chemical compound OC(=O)CC(C(O)=O)S(O)(=O)=O ULUAUXLGCMPNKK-UHFFFAOYSA-N 0.000 description 1
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 238000002835 absorbance Methods 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 description 1
- 239000010775 animal oil Substances 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- QCYLIQBVLZBPNK-UHFFFAOYSA-N asiaticoside A Natural products O1C(C(=O)C(C)C)=CC(C)C(C2(C(OC(C)=O)CC34C5)C)C1CC2(C)C3CCC(C1(C)C)C45CCC1OC1OCC(O)C(O)C1O QCYLIQBVLZBPNK-UHFFFAOYSA-N 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- RWCCWEUUXYIKHB-UHFFFAOYSA-N benzophenone Chemical compound C=1C=CC=CC=1C(=O)C1=CC=CC=C1 RWCCWEUUXYIKHB-UHFFFAOYSA-N 0.000 description 1
- 229960002903 benzyl benzoate Drugs 0.000 description 1
- 230000008687 biosynthesis inhibition Effects 0.000 description 1
- 239000001273 butane Substances 0.000 description 1
- 235000019437 butane-1,3-diol Nutrition 0.000 description 1
- 239000000378 calcium silicate Substances 0.000 description 1
- 229910052918 calcium silicate Inorganic materials 0.000 description 1
- OYACROKNLOSFPA-UHFFFAOYSA-N calcium;dioxido(oxo)silane Chemical compound [Ca+2].[O-][Si]([O-])=O OYACROKNLOSFPA-UHFFFAOYSA-N 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 239000013592 cell lysate Substances 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 150000005827 chlorofluoro hydrocarbons Chemical class 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 239000012468 concentrated sample Substances 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 230000006837 decompression Effects 0.000 description 1
- RWYFURDDADFSHT-RBBHPAOJSA-N diane Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1.C1=C(Cl)C2=CC(=O)[C@@H]3CC3[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(C)=O)(OC(=O)C)[C@@]1(C)CC2 RWYFURDDADFSHT-RBBHPAOJSA-N 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 229910001873 dinitrogen Inorganic materials 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 210000000918 epididymis Anatomy 0.000 description 1
- 201000010063 epididymitis Diseases 0.000 description 1
- 210000002919 epithelial cell Anatomy 0.000 description 1
- 229940011871 estrogen Drugs 0.000 description 1
- 239000000262 estrogen Substances 0.000 description 1
- LYCAIKOWRPUZTN-UHFFFAOYSA-N ethylene glycol Natural products OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 150000002191 fatty alcohols Chemical class 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 210000001061 forehead Anatomy 0.000 description 1
- 210000004392 genitalia Anatomy 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 239000012676 herbal extract Substances 0.000 description 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
- 208000013403 hyperactivity Diseases 0.000 description 1
- MTNDZQHUAFNZQY-UHFFFAOYSA-N imidazoline Chemical class C1CN=CN1 MTNDZQHUAFNZQY-UHFFFAOYSA-N 0.000 description 1
- 230000009545 invasion Effects 0.000 description 1
- SUMDYPCJJOFFON-UHFFFAOYSA-N isethionic acid Chemical compound OCCS(O)(=O)=O SUMDYPCJJOFFON-UHFFFAOYSA-N 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 229940039717 lanolin Drugs 0.000 description 1
- 235000019388 lanolin Nutrition 0.000 description 1
- 230000037356 lipid metabolism Effects 0.000 description 1
- 239000012139 lysis buffer Substances 0.000 description 1
- 229940090813 madecassoside Drugs 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000035800 maturation Effects 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 239000013081 microcrystal Substances 0.000 description 1
- CQDGTJPVBWZJAZ-UHFFFAOYSA-N monoethyl carbonate Chemical compound CCOC(O)=O CQDGTJPVBWZJAZ-UHFFFAOYSA-N 0.000 description 1
- IJDNQMDRQITEOD-UHFFFAOYSA-N n-butane Chemical compound CCCC IJDNQMDRQITEOD-UHFFFAOYSA-N 0.000 description 1
- OFBQJSOFQDEBGM-UHFFFAOYSA-N n-pentane Natural products CCCCC OFBQJSOFQDEBGM-UHFFFAOYSA-N 0.000 description 1
- 229930027945 nicotinamide-adenine dinucleotide Natural products 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 230000002018 overexpression Effects 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 235000020744 piper nigrum extract Nutrition 0.000 description 1
- 239000000419 plant extract Substances 0.000 description 1
- 229920002647 polyamide Polymers 0.000 description 1
- 229920000656 polylysine Polymers 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 239000001294 propane Substances 0.000 description 1
- 239000003380 propellant Substances 0.000 description 1
- 229940055019 propionibacterium acne Drugs 0.000 description 1
- 235000013772 propylene glycol Nutrition 0.000 description 1
- 210000002307 prostate Anatomy 0.000 description 1
- 238000011002 quantification Methods 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 229940071089 sarcosinate Drugs 0.000 description 1
- FSYKKLYZXJSNPZ-UHFFFAOYSA-N sarcosine Chemical compound C[NH2+]CC([O-])=O FSYKKLYZXJSNPZ-UHFFFAOYSA-N 0.000 description 1
- 210000004761 scalp Anatomy 0.000 description 1
- 210000004378 sebocyte Anatomy 0.000 description 1
- 230000001568 sexual effect Effects 0.000 description 1
- 230000004096 skeletal muscle tissue growth Effects 0.000 description 1
- 210000004927 skin cell Anatomy 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 150000003467 sulfuric acid derivatives Chemical class 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 229940104261 taurate Drugs 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 238000011282 treatment Methods 0.000 description 1
- GPRLSGONYQIRFK-MNYXATJNSA-N triton Chemical compound [3H+] GPRLSGONYQIRFK-MNYXATJNSA-N 0.000 description 1
- 238000000108 ultra-filtration Methods 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 239000002023 wood Substances 0.000 description 1
- 239000011787 zinc oxide Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/006—Antidandruff preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Cosmetics (AREA)
Abstract
본 발명은 벌나무(Acer tegmentosum) 및 함박꽃나무(Magnolia Sieboldii)의 혼합 추출물을 유효성분으로 포함하는 화장료 조성물로써, 구체적으로는 여드름균, 비듬균 및 황색포도상구균에 대하여 우수한 항균 활성을 갖는 여드름 및 비듬 완화 및 피지 분비 억제용 화장료 조성물에 관한 것이다.The present invention is a cosmetic composition containing mixed extracts of Acer tegmentosum and Magnolia Sieboldii as active ingredients, specifically, alleviating acne and dandruff with excellent antibacterial activity against acne bacteria, dandruff bacteria, and Staphylococcus aureus. and a cosmetic composition for suppressing sebum secretion.
Description
본 발명은 벌나무(Acer tegmentosum) 및 함박꽃나무(Magnolia Sieboldii) 혼합추출물을 포함하는 화장료 조성물로써, 구체적으로는 여드름균, 비듬균, 황색포도상구균에 대하여 우수한 항균 활성을 갖고 피지 분비 억제 효과를 갖는 여드름 및 비듬 완화 및 피부 보효용 화장료 조성물에 관한 것이다.The present invention is a cosmetic composition containing mixed extracts of Acer tegmentosum and Magnolia Sieboldii , specifically, having excellent antibacterial activity against acne bacteria, dandruff bacteria, and Staphylococcus aureus, and having a sebum secretion inhibition effect. It relates to a cosmetic composition for dandruff relief and skin care.
5α-리덕테이즈(5-reductase)는 피지선, 모낭, 전립선, 부고환 등의 남성 호르몬 반응성 조직에 존재하며, 남성 호르몬들 중 하나인 테스토스테론(Testosterone)을 다이하이드로테스토스테론(Dihydrotestosterone:DHT)으로 환원시키는데 관여하는 효소로서 그 전환에는 엔에이디피에이치(NADPH)를 필요로 한다. 남성 성충동, 골격근증가, 남성외부생식기, 음낭 성장, 정자 형성 등에는 테스토스테론이 관여하고, 여드름, 피지, 전립선비대증 등에는 다이하이드로테스토스테론이 해당 조직에서 관여한다.(Diane et al; JID 775-778, 1995. Bruchovsky, Net al; JBC 243,2112~2121, 1968). 따라서, 5α-리덕테이즈 효소의 억제제를 사용하여 여드름 치료제 및 피지분비 억제제를 개발하려는 연구들이 활발히 진행되고 있다.5α-reductase is present in male hormone-reactive tissues such as sebaceous glands, hair follicles, prostate, and epididymis, and reduces testosterone, one of the male hormones, to dihydrotestosterone (DHT). As an enzyme involved, NADPH is required for the conversion. Testosterone is involved in male sexual drive, skeletal muscle growth, male external genitalia, scrotal growth, sperm formation, etc., and dihydrotestosterone is involved in acne, sebum, and benign prostatic hypertrophy in the corresponding tissues. (Diane et al; JID 775-778, 1995. Bruchovsky, et al; JBC 243,2112~2121, 1968). Therefore, research is being actively conducted to develop acne treatments and sebum secretion inhibitors using inhibitors of the 5α-reductase enzyme.
일반적으로 두피, 얼굴을 포함한 피부에서 피지는, 피부의 보습유지나 미생물의 침입을 막는 역할을 담당하고 있지만, 사춘기 이후에는 여드름을 유발 시킨다. 특히, 20대 이후의 여성의 경우에는 피지의 과잉 분비로 인해 피부 번들거림, 화장의 들뜸 및 모공이 넓어지는 등 미용 면에서 많은 문제를 유발시킨다. 피지 과잉이 일어나는 데는 여러가지 원인이 관여하고 있는데, 그 중에서도 가장 중요한 것은 피지선의 활성에 있어 피지 분비를 촉진하는데 관여하는 호르몬의 하나인 다이하이드로테스토스테론의 양에 의해서 피지선의 세포가 활성화되어 피지 과분비가 일어난다고 알려져 있다.In general, sebum on the skin, including the scalp and face, plays a role in maintaining skin moisture and preventing the invasion of microorganisms, but after puberty, it causes acne. In particular, for women in their 20s or older, excessive secretion of sebum causes many cosmetic problems such as shiny skin, flaky makeup, and enlarged pores. There are various causes involved in the occurrence of excessive sebum, the most important of which is the amount of dihydrotestosterone, one of the hormones involved in promoting sebum secretion in the activity of the sebaceous glands, which activates the cells of the sebaceous glands and causes sebum hypersecretion. It is known.
여드름은 하나의 원인이 아니라 여러 가지 원인이 복합적으로 관여하는데, 사춘기의 남성 호르몬 기능 항진으로 피지선의 분비가 왕성해지고 모낭의 상피세포가 이상을 이르켜 모낭이 막히고 이로 인해 여드름의 기본 병변인 면포가 형성된다. 모낭 내에 상주하는 균은 자유-지방산(free fatty acid)을 생성하여 모낭을 자극하여 염증을 유발한다. 이러한 여드름으로의 진행은 피지 과분비로 인해 더욱 악화된다. 피지선은 안드로겐을 생성하고, 지질합성에 관여하는 효소의 발현을 증가시킴으로써, 지질 합성을 촉진시키는데, 이와 관련된 효소로는 Fatty acid synthase, acetyl-CoA carboxylase, ATP-citrate lyase 등이 있다. 이러한 지질 대사과 관련된 효소들은 SRE이라는 전자 조절 부위를 가지며, 안드로겐은 SRE에 결합하는 SREBP를 조절함으로써 지질합성과 관련된 효소들을 조절하는것으로 알려져 있다. 또한 자유-지방산의 생성은 여드름균의 군집형성과 균체 형성을 촉진하게 됨으로써, 피부 염증을 유발하게 되고 각질을 두텁게 한다.Acne is not caused by just one cause, but by a combination of various causes. Due to the hyperactivity of male hormones during puberty, the secretion of sebaceous glands becomes active and the epithelial cells of the hair follicles become abnormal, causing the hair follicles to become clogged, resulting in comedones, which are the basic lesions of acne. is formed Bacteria residing within hair follicles produce free fatty acid, which stimulates the hair follicles and causes inflammation. This progression to acne is further worsened by sebum hypersecretion. Sebaceous glands produce androgens and promote lipid synthesis by increasing the expression of enzymes involved in lipid synthesis, including fatty acid synthase, acetyl-CoA carboxylase, and ATP-citrate lyase. These enzymes related to lipid metabolism have an electronic regulatory region called SRE, and androgens are known to control enzymes related to lipid synthesis by controlling SREBP that binds to SRE. Additionally, the production of free fatty acids promotes the colonization and formation of acne bacteria, causing skin inflammation and thickening the dead skin cells.
여드름 치료를 위해, 종래에는 에스트로겐 등의 여성 호르몬을 사용하거나 5α-리덕테이즈 억제제를 이용해왔다. 그러나 이러한 여성 호르몬제들은 여드름 치료 효과 외에, 피부 염증 발생, 호르몬 투여에 의한 부작용 발생 등이 보고 되고 있어, 현재는 사용을 중단하거나 매우 극미량을 사용하고 있는 실정이다. To treat acne, female hormones such as estrogen or 5α-reductase inhibitors have been used conventionally. However, in addition to the effect of treating acne, these female hormones have been reported to cause skin inflammation and side effects due to hormone administration, so they are currently being discontinued or used in extremely small amounts.
화장품 분야에서도 피지의 과분비는 화장품의 들뜸이나 모공이 넓어지게 되는 요인으로서 중요한 관심의 대상임에도 불구하고 그 연구는 미미한 실정이다. 현재 피지 억제 화장품은, 일시적으로 피지를 흡착시키는 다공성 파우더를 사용하거나, 기존에 피지를 억제한다고 알려진 생약 추출물인 아이비 추출물 등을 화장품 원료로 사용하고 있으나 그 효과는 미미하며 안전한 천연추출물 유래의 피지 분비를 억제를 통한 여드름 증상 완화 효과를 가지는 화장료 조성물의 개발이 필요한 실정이다.Even in the field of cosmetics, excessive secretion of sebum is a factor that causes flaking of cosmetics and enlarged pores, and although it is a subject of important interest, research on it is minimal. Currently, sebum suppressing cosmetics use porous powder that temporarily absorbs sebum, or use ivy extract, a herbal extract known to suppress sebum, as a cosmetic raw material, but the effect is minimal and secretes sebum derived from safe natural extracts. There is a need to develop a cosmetic composition that has the effect of relieving acne symptoms by suppressing .
한국등록특허 제10-1064904호에서는 황련 추출물, 어성초 추출물, 은행 추출물 및 마데카소사이드를 유효성분으로 포함하는 여드름 개선용 화장료 조성물을 개시한다.Korean Patent No. 10-1064904 discloses a cosmetic composition for improving acne containing yellow lotus extract, Houttuynia cordata extract, ginkgo extract, and madecassoside as active ingredients.
한국공개특허 제10-2021-0048021호에서는 당귤껍질 추출물, 후박 추출물 및 폴리리신을 포함하는 항균용 조성물을 개시한다. Korean Patent Publication No. 10-2021-0048021 discloses an antibacterial composition containing tangerine peel extract, black pepper extract, and polylysine.
본 발명자는 여드름 및 비듬을 개선하기 위해 천연 식물 성분들에 대한 다양한 피부 생리활성을 검색한 결과, 천연 식물 추출물 중에서 벌나무(Acer tegmentosum)와 함박꽃나무(Magnolia Sieboldii) 추출물로부터 효능을 확인하여, 이의 혼합추출물의 연구를 통하여 배합비를 통하여 우수한 항균 활성을 가지는 추출 방법과 조성비를 확인함으로써 본 발명을 완성하였다. As a result of searching various skin physiological activities of natural plant ingredients to improve acne and dandruff, the present inventor confirmed the efficacy of extracts from Acer tegmentosum and Magnolia Sieboldii among natural plant extracts, and used a mixture thereof. Through research on the extract, the present invention was completed by confirming the extraction method and composition ratio with excellent antibacterial activity through mixing ratio.
본 발명은 여드름 및 비듬 개선 효과를 갖는 화장료 조성물을 제공하는 것을 목적으로 한다. The purpose of the present invention is to provide a cosmetic composition that has an acne and dandruff improvement effect.
상기한 목적은 벌나무(Acer tegmentosum) 추출물 및 함박꽃나무(Magnolia Sieboldii) 추출물의 혼합추출물을 유효성분으로 포함하는 여드름 및 비듬 완화용 화장료 조성물에 의해 달성된다.The above objective is achieved by a cosmetic composition for alleviating acne and dandruff containing a mixed extract of Acer tegmentosum extract and Magnolia Sieboldii extract as an active ingredient.
바람직하게는, 상기 화장료 조성물은 황색포도상구균, 여드름균 또는 비듬균에 대해 항균 효과를 갖는다.Preferably, the cosmetic composition is against Staphylococcus aureus, Acne acnes, or dandruff bacteria. It has an antibacterial effect.
또한 바람직하게는, 상기 화장료 조성물은 피지분비 억제 효과를 갖는다.Also preferably, the cosmetic composition has a sebum secretion inhibition effect.
또한 바람직하게는, 상기 벌나무 추출물과 함박꽃나무 추출물을 10:1 내지 7:1의 중량비로 혼합될 수 있다.Also preferably, the bee tree extract and the Chrysanthemum chinensis extract may be mixed at a weight ratio of 10:1 to 7:1.
또한 바람직하게는, 상기 벌나무 추출물 및 상기 함박꽃나무 추출물의 혼합 추출물은 화장료 조성물 총 중량 대비 0.0001 내지 30.0 중량%로 포함될 수 있다.Also preferably, the mixed extract of the bee tree extract and the Hambak flower tree extract may be included in an amount of 0.0001 to 30.0% by weight based on the total weight of the cosmetic composition.
또한 바람직하게는, 상기 벌나무 추출물 및 상기 함박꽃나무 추출물은 물, 탄소수 1-4개의 무수 또는 함수 저급 알코올, 아세톤, 에틸 아세테이트 및 부틸 아세테이트로 구성된 군으로부터 선택되는 추출용매로 추출될 수 있다.Also preferably, the bee tree extract and the cypress tree extract may be extracted with an extraction solvent selected from the group consisting of water, anhydrous or hydrous lower alcohols having 1 to 4 carbon atoms, acetone, ethyl acetate, and butyl acetate.
또한 바람직하게는, 상기 화장료는 용액, 현탁액, 유탁액, 페이스트, 젤, 크림, 로션, 파우더, 비누, 계면활성제-함유 클렌징, 오일, 분말 파운데이션, 유탁액 파운데이션, 왁스 파운데이션 및 스프레이로 구성된 군으로부터 선택되는 제형을 가질 수 있다. Also preferably, the cosmetic is selected from the group consisting of solutions, suspensions, emulsions, pastes, gels, creams, lotions, powders, soaps, surfactant-containing cleansing agents, oils, powder foundations, emulsion foundations, wax foundations and sprays. It can have any dosage form selected.
본 발명에 따른 화장료 조성물은 벌나무, 함박꽃나무 혼합추출물을 일정비율 유효성분으로 함유하여 우수한 여드름 완화, 비듬 완화 및 피지 분비 억제 효과를 갖는다.The cosmetic composition according to the present invention contains a certain ratio of mixed extracts of bee tree and cypress tree as active ingredients, and has excellent acne alleviation, dandruff alleviation, and sebum secretion inhibition effects.
본 발명에서 사용되는 모든 기술용어는, 달리 정의되지 않는 이상, 하기의 정의를 가지며 본 발명의 관련 분야에서 통상의 당업자가 일반적으로 이해하는 바와 같은 의미에 부합된다. 또한 본 명세서에는 바람직한 방법이나 시료가 기재되나, 이와 유사하거나 동등한 것들도 본 발명의 범주에 포함된다. All technical terms used in the present invention, unless otherwise defined, have the following definitions and correspond to the meaning as generally understood by a person skilled in the art in the relevant field of the present invention. In addition, preferred methods and samples are described in this specification, but similar or equivalent methods are also included in the scope of the present invention.
용어 "약"이라는 것은 참조 양, 수준, 값, 수, 빈도, 퍼센트, 치수, 크기, 양, 중량 또는 길이에 대해 30, 25, 20, 25, 10, 9, 8, 7, 6, 5, 4, 3, 2 또는 1% 정도로 변하는 양, 수준, 값, 수, 빈도, 퍼센트, 치수, 크기, 양, 중량 또는 길이를 의미한다. The term “about” refers to a quantity, level, value, number, frequency, percent, dimension, size, amount, weight or length of 30, 25, 20, 25, 10, 9, 8, 7, 6, 5, means a quantity, level, value, number, frequency, percentage, dimension, size, volume, weight or length that varies by 4, 3, 2 or 1%.
본 명세서를 통해, 문맥에서 달리 필요하지 않으면, "포함하다" 및 "포함하는"이란 말은 제시된 단계 또는 구성요소, 또는 단계 또는 구성요소들의 군을 포함하나, 임의의 다른 단계 또는 구성요소, 또는 단계 또는 구성요소들의 군이 배제되지는 않음을 내포하는 것으로 이해하여야 한다. Throughout this specification, unless the context otherwise requires, the words "comprise" and "comprising" include a given step or component, or group of steps or components, but any other step or component, or It should be understood that this implies that no step or group of components is excluded.
본 발명은 벌나무(Acer tegmentosum) 추출물 및 함박꽃나무(Magnolia Sieboldii) 추출물의 혼합추출물을 유효 성분으로 포함하는 화장료 조성물에 관한 것이다.The present invention relates to a cosmetic composition containing a mixed extract of Acer tegmentosum extract and Magnolia Sieboldii extract as an active ingredient.
본 발명에 사용된 벌나무(Acer tegmentosum)은 쌍떡잎식물 무환자나무목 단풍나무과의 낙엽소교목으로써, 나무껍질은 매끄럽고 작은 가지는 녹색을 띄고 있으며 깊은 산의 계속에서 자란다. 벌나무의 목질은 단단하여 가구재로써 많이 이용되고 있다.The bee tree (Acer tegmentosum) used in the present invention is a deciduous small tree of the maple family of the dicotyledonous order Acer tegmentosum. The tree has smooth bark, green small branches, and grows deep in the mountains. The wood of the bee tree is hard and is often used as furniture material.
또한, 함박꽃나무(Magnolia Sieboldii) 추출물을 유효 성분으로 포함하는 화장료 조성물로써, 본 발명에 사용된 함박꽃나무(Magnolia Sieboldii)은 목련과의 낙엽 활엽 소 교목으로서, 높이는 7미터 정도이며, 잎은 어긋나고 긴 타원형으로 광택이 난다. 5~6월에 흰색의 큰 꽃이 밑을 향해 피고 열매는 9월에 익는다. 주로 관상용으로 사용되며 깊은 산의 중턱 골짜기에서 자라며 함북을 제외한 한국 각지와 일본, 중국 등지에 분포한다In addition, it is a cosmetic composition containing Magnolia Sieboldii extract as an active ingredient. Magnolia Sieboldii used in the present invention is a deciduous broad-leaved small tree of the Magnolia family, with a height of about 7 meters, and the leaves are alternate and long. It is oval and shiny. Large white flowers bloom downward from May to June, and the fruit ripens in September. It is mainly used for ornamental purposes, grows in deep mountain valleys, and is distributed throughout Korea, Japan, and China except Hambuk.
본 발명의 벌나무 추출물 및 함박꽃나무 추출물은 당업계에 공지된 통상의 방법에 따라, 즉, 통상적인 온도와 압력의 조건하에서, 통상적인 용매를 사용하여 제조될 수 있다. 바람직하게는 (a) 물, 탄소수 1-4의 무수 또는 함수 저급 알코올(예를 들면, 메탄올, 에탄올, 프로판올 및 부탄올), 프로필렌글리콜, 1,3-부틸렌글리콜, 글리세린, 아세톤, 디에틸에테르, 에틸 아세테이트, 부틸아세테이트, 디클로로메탄, 클로로포름, 헥산 및 이들의 혼합물로 구성된 군으로부터 선택되는 용매를 이용한 용매 추출법 (b) 이산화탄소에 의한 감압 및 고온에 의한 초임계 추출법 또는 (c) 초음파 추출법을 이용하여 추출한다. The bee tree extract and the Chrysanthemum chinensis extract of the present invention can be prepared according to conventional methods known in the art, that is, under conventional conditions of temperature and pressure, using conventional solvents. Preferably (a) water, anhydrous or hydrous lower alcohols having 1 to 4 carbon atoms (e.g. methanol, ethanol, propanol and butanol), propylene glycol, 1,3-butylene glycol, glycerin, acetone, diethyl ether. , solvent extraction using a solvent selected from the group consisting of ethyl acetate, butyl acetate, dichloromethane, chloroform, hexane, and mixtures thereof (b) supercritical extraction using reduced pressure and high temperature using carbon dioxide, or (c) ultrasonic extraction. and extract it.
본 발명에서는 바람직하게는 추출용매를 이용한 용매 추출법을 이용하였다. 본 발명에서 벌나무 추출물 및 함박꽃나무 추출물은 다양한 추출용매, 예를 들어, 물, 탄소수 1-4의 무수 또는 함수 저급 알코올 (예를 들면, 메탄올, 에탄올, 프로판올 및 부탄올, 프로필렌글리콜, 1,3-부틸렌글리콜, 글리세린, 아세톤, 디에틸에테르, 에틸 아세테이트, 부틸아세테이트, 디클로로메탄, 클로로포름, 헥산 및 이들의 혼합물로 구성된 군으로부터 선택되는 1종 이상의 추출 용매를 사용하여 얻을 수 있으며, 바람직하게는 에탄올, 70%(v/v) 에탄올 또는 물을 사용하여 얻어진 것이고, 가장 바람직하게는 70%(v/v) 에탄올을 사용하여 얻어진 것이다. In the present invention, a solvent extraction method using an extraction solvent was preferably used. In the present invention, the bee tree extract and the Chrysanthemum chinensis extract are extracted with various extraction solvents, such as water, anhydrous or hydrous lower alcohols having 1-4 carbon atoms (e.g., methanol, ethanol, propanol and butanol, propylene glycol, 1,3- It can be obtained using one or more extraction solvents selected from the group consisting of butylene glycol, glycerin, acetone, diethyl ether, ethyl acetate, butyl acetate, dichloromethane, chloroform, hexane, and mixtures thereof, preferably ethanol. , obtained using 70% (v/v) ethanol or water, and most preferably obtained using 70% (v/v) ethanol.
한편, 본 발명의 벌나무 추출물 및 함박꽃나무은 상기한 추출 용매뿐만 아니라, 다른 추출 용매를 이용하여도 실질적으로 동일한 효과를 나타내는 추출물이 얻어질 수 있다는 것은 당업자에게 자명한 것이다. 또한, 본 발명의 벌나무 추출물 및 함박꽃나무 추출물은 상술한 추출 용매에 의한 추출물뿐만 아니라, 통상적인 정제 및 발효 과정을 거친 추출물도 포함한다. 예컨대, 이산화탄소에 의한 감압, 고온에 의한 초임계추출법에 의한 추출, 초음파를 이용한 추출법에 의한 추출, 일정한 분자량 컷-오프 값을 갖는 한외 여과막을 이용한 분리, 다양한 크로마토그래피 (크기, 전하, 소수성 또는 친화성에 따른 분리를 위해 제작된 것)에 의한 분리하거나 자연 상태나 각종 미생물을 이용한 발효산물에 의한 추출물 등, 추가적으로 실시된 다양한 정제 및 추출방법을 통해 얻어진 활성 분획도 본 발명의 추출물에 포함된다.Meanwhile, it is obvious to those skilled in the art that extracts showing substantially the same effect can be obtained using the bee tree extract and the Chrysanthemum chinensis tree of the present invention not only using the above-mentioned extraction solvent but also other extraction solvents. In addition, the bee tree extract and the Chrysanthemum chinensis extract of the present invention include not only extracts using the above-described extraction solvent, but also extracts that have undergone conventional purification and fermentation processes. For example, decompression with carbon dioxide, extraction by supercritical extraction at high temperature, extraction by ultrasonic extraction, separation using an ultrafiltration membrane with a certain molecular weight cut-off value, and various chromatographies (size, charge, hydrophobicity or affinity). Active fractions obtained through various additional purification and extraction methods, such as separation by (designed for separation according to gender) or extracts from fermentation products in the natural state or using various microorganisms, are also included in the extract of the present invention.
본 발명에 따른 벌나무 및 함박꽃나무 추출물은 발효과정을 거친 추출물도 포함하는데 발효추출물은 다음과 같이 제조할 수 있다. 벌나무과 함박꽃나무의 줄기부를 100~500메쉬 정도로 미세하게 파쇄한 다음 통상적인 미생물 배양액을 1~50g/L를 첨가하고 효모 균주 또는 유산균등의 미생물을 10,000~100,000 cfu/L의 양으로 첨가한다. 배양온도는 30~37℃의 통상적인 미생물 배양조건으로 배양한다. pH는 5~7로 호기적 또는 통상 혐기(anaerobic)적인 조건으로 약 5내지 10일간 배양한다. 이후 숙성 및 여과를 통해 얻을 수 있다. The bee tree and Hambac tree extracts according to the present invention also include extracts that have undergone a fermentation process, and the fermented extracts can be prepared as follows. The stems of the bee and cypress trees are finely crushed to a mesh size of 100 to 500, then 1 to 50 g/L of a typical microbial culture medium is added, and microorganisms such as yeast strains or lactic acid bacteria are added in an amount of 10,000 to 100,000 cfu/L. The culture temperature is 30-37°C under typical microbial culture conditions. The pH is 5 to 7 and cultured under aerobic or anaerobic conditions for about 5 to 10 days. It can then be obtained through maturation and filtration.
본 발명에 따르면, 상기 벌나무(Acer tegmentosum) 및 함박꽃나무(Magnolia Sieboldii) 추출물의 혼합추출물은 화장료 조성물의 전체 중량에 대해서 0.0001 ~ 30.0 중량%로 함유되며, 더욱 바람직하게는, 상기 벌나무(Acer tegmentosum) 및 함박꽃나무(Magnolia Sieboldii) 추출물의 혼합추출물은 화장료 조성물의 전체 중량에 대해서 0.01 ~ 10 중량% 함유되는 것을 특징으로 한다. According to the present invention, the mixed extract of the Acer tegmentosum and Magnolia Sieboldii extracts is contained in an amount of 0.0001 to 30.0% by weight based on the total weight of the cosmetic composition, more preferably, the Acer tegmentosum And the mixed extract of Magnolia Sieboldii extract is characterized in that it contains 0.01 to 10% by weight based on the total weight of the cosmetic composition.
상기 추출물의 함량이 0.001 중량% 미만인 경우에는 피부개선 효과가 나타나지 않으며, 30.0 중량%를 초과하는 경우에는 제형상의 안전 및 안정성에 문제가 있으며 경제적이지도 못하다.If the content of the extract is less than 0.001% by weight, no skin improvement effect is observed, and if it exceeds 30.0% by weight, there are problems with the safety and stability of the formulation and it is not economical.
본 발명의 화장료 조성물에 포함되는 성분은 유효 성분으로서 상기 유효 성분 이외에 화장료 조성물에 통상적으로 이용되는 성분들을 포함할 수 있으며, 예컨대 항산화제, 안정화제, 용해화제, 비타민, 안료 및 향료와 같은 통상적인 보조제, 그리고 담체를 포함한다. 본 발명의 화장료 조성물은 당업계에서 통상적으로 제조되는 어떠한 제형으로도 제조될 수 있으며, 예를 들어, 용액, 현탁액, 유탁액, 페이스트, 겔, 크림, 로션, 파우더, 비누, 계면활성제-함유 클렌징, 오일, 분말 파운데이션, 유탁액 파운데이션, 왁스 파운데이션, 팩, 마사지크림 및 스프레이 등으로 제형화될 수 있으나, 이에 한정되는 것은 아니다. 보다 상세하게는, 유연 화장수, 영양 화장수, 영양 크림, 마사지 크림, 에센스, 아이크림, 클렌징 크림, 클렌징 폼, 클렌징 워터, 팩, 스프레이 또는 파우더의 제형으로 제조될 수 있다. The ingredients included in the cosmetic composition of the present invention are active ingredients and may include ingredients commonly used in cosmetic compositions in addition to the above-mentioned active ingredients, such as antioxidants, stabilizers, solubilizers, vitamins, pigments and fragrances. Includes adjuvants and carriers. The cosmetic composition of the present invention can be prepared in any formulation commonly prepared in the art, for example, solutions, suspensions, emulsions, pastes, gels, creams, lotions, powders, soaps, surfactant-containing cleansing products. , oil, powder foundation, emulsion foundation, wax foundation, pack, massage cream and spray, etc., but is not limited thereto. More specifically, it can be manufactured in the form of softening lotion, nourishing lotion, nourishing cream, massage cream, essence, eye cream, cleansing cream, cleansing foam, cleansing water, pack, spray, or powder.
본 발명의 제형이 페이스트, 크림 또는 겔인 경우에는 담체 성분으로서 동물성유, 식물성유, 왁스, 파라핀, 전분, 트라칸트, 셀룰로오스 유도체, 폴리에틸렌 글리콜, 실리콘, 벤토나이트, 실리카, 탈크 또는 산화아연등이 이용될 수 있다. When the formulation of the present invention is a paste, cream or gel, animal oil, vegetable oil, wax, paraffin, starch, tracant, cellulose derivative, polyethylene glycol, silicone, bentonite, silica, talc or zinc oxide may be used as the carrier ingredient. You can.
본 발명의 제형이 용액 또는 유탁액인 경우에는 담체 성분으로서 용매, 용해화제 또는 유탁화제가 이용되고, 예컨대 물, 에탄올, 이소프로판올, 에틸 카보네이트, 에틸 아세테이트, 벤질 알코올, 벤질 벤조에이트, 프로필렌글리콜, 1,3-부틸글리콜 오일, 글리세롤 지방족 에스테르, 폴리에틸렌글리콜 또는 소르비탄의 지방산 에스테르가 있다. When the formulation of the present invention is a solution or emulsion, a solvent, solubilizing agent, or emulsifying agent is used as a carrier component, such as water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene glycol, 1 , 3-butyl glycol oil, glycerol aliphatic ester, polyethylene glycol, or fatty acid ester of sorbitan.
본 발명의 제형이 현탁액인 경우에는 담체 성분으로서 물, 에탄올 또는 프로필렌글리콜과 같은 액상의 희석제, 에톡실화 이소스테아릴 알코올, 폴리옥시에틸렌 소르비톨 에스테르 및 폴리옥시에틸렌 소르비탄 에스테르와 같은 현탁제, 미소 결정성 셀룰로오스, 알루미늄 메타히드록시드, 벤토나이트, 아가 또는 트라칸트 등이 이용될 수 있다. 본 발명의 제형이 파우더 또는 스프레이인 경우에는 담체 성분으로서 락토스, 탈크, 실리카, 알루미늄 히드록시드, 칼슘 실리케이트 또는 폴리아미드 파우더가 이용될 수 있고, 특히 스프레이인 경우에는 추가적으로 클로로플루오로히드로카본, 프로판/부탄 또는 디메틸 에테르와 같은 추진체를 포함할 수 있다. When the formulation of the present invention is a suspension, the carrier ingredients include water, a liquid diluent such as ethanol or propylene glycol, a suspending agent such as ethoxylated isostearyl alcohol, polyoxyethylene sorbitol ester, and polyoxyethylene sorbitan ester, and microcrystals. Cellulose, aluminum metahydroxide, bentonite, agar, or tracant may be used. When the formulation of the present invention is a powder or spray, lactose, talc, silica, aluminum hydroxide, calcium silicate, or polyamide powder can be used as the carrier ingredient. In particular, when the formulation is a spray, chlorofluorohydrocarbon and propane may be used as carrier ingredients. /May contain propellants such as butane or dimethyl ether.
본 발명의 제형이 계면활성제 함유 클렌징인 경우에는 담체 성분으로서 지방족 알코올 설페이트, 지방족 알코올 에테르 설페이트, 설포숙신산모노에스테르, 이세티오네이트, 이미다졸리늄 유도체, 메틸타우레이트, 사르코시네이트, 지방산 아미드 에테르 설페이트, 알킬아미도베타인, 지방족알코올, 지방산 글리세리드, 지방산 디에탄올아미드, 식물성 유, 라놀린 유도체 또는 에톡실화 글리세롤 지방산 에스테르 등이 이용될 수 있다.When the formulation of the present invention is a surfactant-containing cleansing agent, the carrier ingredients include aliphatic alcohol sulfate, aliphatic alcohol ether sulfate, sulfosuccinic acid monoester, isethionate, imidazolinium derivative, methyl taurate, sarcosinate, and fatty acid amide ether. Sulfates, alkylamidobetaines, fatty alcohols, fatty acid glycerides, fatty acid diethanolamides, vegetable oils, lanolin derivatives, or ethoxylated glycerol fatty acid esters may be used.
본 발명의 화장료 조성물이 비누, 계면활성제 함유 클렌징 제형 또는 계면활성제 비함유 클렌징 제형일 경우, 피부에 도포한 후 닦아내거나 떼거나 물로 씻어낼 수도 있다. 구체적인 예로서, 상기 비누는 액상비누, 가루비누, 고형비누 및 오일비누이며, 상기 계면활성제 함유 클렌징 제형은 클렌징 폼, 클렌징 워터, 클렌징 수건 및 클렌징 팩이며, 상기 계면활성제 비함유 클렌징 제형은 클렌징크림, 클렌징 로션, 클렌징 워터 및 클렌징 겔이며, 이에 한정되는 것은 아니다.When the cosmetic composition of the present invention is a soap, a surfactant-containing cleansing formulation, or a surfactant-free cleansing formulation, it can be applied to the skin and then wiped off, removed, or washed with water. As a specific example, the soap is liquid soap, powdered soap, solid soap, and oil soap, the surfactant-containing cleansing formulation is cleansing foam, cleansing water, cleansing towel, and cleansing pack, and the surfactant-free cleansing formulation is cleansing cream. , cleansing lotion, cleansing water, and cleansing gel, but are not limited thereto.
한편, 본 발명의 화장 방법은 본 발명의 화장료 조성물을 이용하는 모든 화장 방법을 일컫는다. 즉, 화장료 조성물을 이용하는 당업계에 공지된 모든 방법이 본 발명의 화장 방법에 속한다. 본 발명의 화장료 조성물은 단독 또는 중복하여 사용하거나, 본 발명 이외의 다른 화장료 조성물과 중복하여 사용할 수 있다. 또한 본 발명에 따른 화장료 조성물은 통상적인 사용방법에 따라 사용될 수 있으며, 사용자의 피부 상태 또는 취향에 따라 그 사용횟수를 달리할 수 있다. Meanwhile, the cosmetic method of the present invention refers to all cosmetic methods using the cosmetic composition of the present invention. That is, all methods known in the art using cosmetic compositions belong to the cosmetic method of the present invention. The cosmetic composition of the present invention can be used alone or in combination, or can be used in combination with other cosmetic compositions other than the present invention. Additionally, the cosmetic composition according to the present invention can be used according to conventional usage methods, and the number of times of use can be varied depending on the user's skin condition or preference.
이하, 실시예를 통하여 본 발명을 더욱 상세히 설명하고자 한다. 이들 실시예는 오로지 본 발명을 보다 구체적으로 설명하기 위한 것으로, 본발명의 요지에 따라 본 발명의 범위가 이들 실시예에 의해 제한되지 않는다Hereinafter, the present invention will be described in more detail through examples. These examples are only for illustrating the present invention in more detail, and the scope of the present invention is not limited by these examples according to the gist of the present invention.
이하에서 실시예를 들어서 본 발명을 상세하게 설명하지만, 이들 실시예에 의해 본 발명의 권리범위가 제한되는 것은 아니다.Hereinafter, the present invention will be described in detail through examples, but the scope of the present invention is not limited by these examples.
제조예 1 - 벌나무(Acer tegmentosum) 추출물 제조 Preparation Example 1 - Preparation of Acer tegmentosum extract
벌나무의 줄기부를 깨끗한 물로 씻어 건조시킨 다음 일정한 크기로 절단하여 0 ~ 70%(V/V) 에탄올 수용액으로 5시간씩 3회 환류 추출하고 냉침한 후, 와트만(Whatman) #4 여과지로 여과하여 농축액을 얻었다.The stem of the bee tree was washed with clean water, dried, cut into pieces of a certain size, extracted under reflux three times for 5 hours each with a 0 to 70% (V/V) ethanol aqueous solution, cold soaked, and then filtered with Whatman #4 filter paper. A concentrate was obtained.
제조예 2 - 함박꽃나무(Magnolia Sieboldii) 추출물 제조 Preparation Example 2 - Preparation of Magnolia Sieboldii extract
함박꽃나무의 줄기부를 깨끗한 물로 씻어 건조시킨 다음 일정한 크기로 절단하여 0 ~ 70%(V/V) 에탄올 수용액으로 5시간씩 3회 환류 추출하고 냉침한 후, 와트만(Whatman) #4 여과지로 여과하여 농축액을 얻었다The stem of the Hambac tree was washed with clean water, dried, cut into pieces of a certain size, extracted under reflux three times for 5 hours each with a 0 to 70% (V/V) ethanol aqueous solution, cold soaked, and then filtered using Whatman #4 filter paper. A concentrate was obtained.
제조예 3 - 벌나무 및 함박꽃나무의 혼합 추출물 제조 Preparation Example 3 - Preparation of mixed extract of bee tree and Hambac tree
상기 제조예 1 및 2에서 획득한 추출물을 각각 1:1 ~ 1:10의 중량비로 혼합하여 상온에서 24시간 보관 후 침전물을 제외한 상등액을 취하여 혼합 추출물을 얻었다.The extracts obtained in Preparation Examples 1 and 2 were mixed at a weight ratio of 1:1 to 1:10, stored at room temperature for 24 hours, and the supernatant excluding the precipitate was taken to obtain a mixed extract.
실험예 1 - 디스크 확산법(Disc-diffusion method)에 의한 항균활성 측정Experimental Example 1 - Measurement of antibacterial activity by disc-diffusion method
상기의 실시예를 통하여 제조한 본 발명의 추출물 및 이로부터 분리한 유효성분에 대한 항균 활성을 확인하기 위하여 디스크 확산법을 이용하였다. 멸균된 페이퍼 디스크에 30% 농도로 준비한 제조예 3을 50ul 분주하여 상온에서 24시간 자연건조를 통하여 용매를 제거 하였다. 배양된 P.acnes(Propionibacterium acnes), M.furfur(Malassezia furfur) 및 S.aureus(Staphylococcus aureus)를 디스크 확산법 측정용 평판배지에 초기 균수(1*107)를 동일하게 하여 1ml씩 분주하여 도말하였다. 이후 페이퍼 디스크는 P.acnes, M.furfur 및 S.aureus가 도말된 평판배지에 붙인 후, 적정온도에서 48시간동안 혐기 또는 호기 배양한 후 생육 저지환(Clean Zone)의 크기를 측정하였다. 그 결과를 하기 표 3 및 표 4에 나타내었다.Disc diffusion method was used to confirm the antibacterial activity of the extract of the present invention prepared through the above examples and the active ingredient isolated therefrom. 50ul of Preparation Example 3 prepared at 30% concentration was dispensed onto a sterilized paper disk and the solvent was removed through natural drying at room temperature for 24 hours. Cultured P.acnes (Propionibacterium acnes), M.furfur (Malassezia furfur), and S.aureus (Staphylococcus aureus) were spread on a plate medium for disc diffusion measurement with the same initial bacterial count (1*10 7 ), dispensed at 1 ml each. did. Afterwards, the paper disk was attached to a plate medium smeared with P. acnes , M. furfur, and S. aureus , and then cultured anaerobically or aerobically for 48 hours at an appropriate temperature, and then the size of the growth zone (clean zone) was measured. The results are shown in Tables 3 and 4 below.
*ND : not detected*ND: not detected
상기의 항균력 평가를 통하여 제조예 1과 제조예 2의 최적의 혼합 중량비가 10:1 ~ 10:7임을 확인할 수 있었다.Through the above antibacterial activity evaluation, it was confirmed that the optimal mixing weight ratio of Preparation Example 1 and Preparation Example 2 was 10:1 to 10:7.
실험예 2 - 지질생합성 억제 효과 Experimental Example 2 - Lipid biosynthesis inhibition effect
피부 염증반응 유발에는 다양한 요인이 존재하고 있으며 특정 균의 과증식은 피부 염증을 유발하는 요인으로 작용하고 있음. 여드름과 비듬의 발생은 여러 원인이 복합적으로 작용되며, 특히 여드름은 남성호르몬의 과잉으로 피지선의 분비가 왕성해지고 모낭이 막혀 여드름의 기본 병변인 면포가 형성되게 되면, 비듬의 경우에는 과도하게 분비된 피지를 영양분으로 하여 과다 증식하게 되는 비듬균에 의한 과각질화, 염증 반응등이 발생됨에 따라 지질생합성의 조절은 여드름과 비듬을 모두 개선할 수 있다. human sebocyte에 열을 가한 다음 단백질을 정량하고 anti-body를 고정 시킨 후 c-digit를 이용하여 protein의 발현(FAS, SREBP-1, PPARγ)을 확인하여 수치화하였다. 그 결과를 표 5에 나타내었다.There are various factors that cause skin inflammatory reactions, and overgrowth of certain bacteria acts as a factor in causing skin inflammation. The occurrence of acne and dandruff is caused by a combination of various causes. In particular, acne occurs when excessive male hormones lead to excessive secretion of sebaceous glands and blockage of hair follicles, leading to the formation of comedones, which are the basic lesions of acne. In the case of dandruff, excessive secretion occurs. Control of lipid biosynthesis can improve both acne and dandruff as hyperkeratinization and inflammatory reactions occur due to dandruff that overproliferates using sebum as a nutrient. After heating human sebocytes, proteins were quantified, anti-body was fixed, and protein expression (FAS, SREBP-1, PPARγ) was confirmed and quantified using c-digit. The results are shown in Table 5.
실험예 3 - 콜레스테롤량 측정Experimental Example 3 - Measurement of cholesterol level
피지 세포를 10 cm 배양용기에 1 X 105개씩 분주하고 제조예 1 및 2를 각각 10, 0 μg/ml의 농도로 처리한 다음, 5일간 배양하고 콜레스테롤를 정량하였다. 콜레스테롤 정량 방법은 상기 5일간 배양된 세포에 라이시스 완충액(EDTA 10 μL, 100mM SPB 용액, PMSF 1 μL, Triton X-100 10 μL)를 처리하 고 초음파로 분해하였다. 세포 용해액에 클로로포름:메탄올(2:1) 용액을 첨가하고 혼합한 다음, 원심분리(2000rpm, 15분)하여 하층액을 취하여 질소가스(N2)로 농축시켰다. 상기 농축된 시료에 에탄올 300 μL를 넣어 녹인 후 total cholesterol kit(AM 202-K)를 이용하여 콜레스테롤 량을 측정하였다. 1 mL의 효소 시액에 100 μL의 시료를 첨가하고 혼합하여 37℃에서 5분 동안 배양 후 500 nm의 파장에서 ELISA reader로 흡광도를 측정하였다. 표준액의 콜레스테롤은 3 mL의 효소시액에 20uL의 표준액을 넣어 3 mg/mL 값으로 하였다. 그 결과를 표 6에 나타내었다.Sebum cells were dispensed into 10 cm culture vessels at a rate of 1 For the cholesterol quantification method, cells cultured for 5 days were treated with lysis buffer (10 μL of EDTA, 100mM SPB solution, 1 μL of PMSF, 10 μL of Triton Chloroform:methanol (2:1) solution was added to the cell lysate and mixed, then centrifuged (2000 rpm, 15 minutes) to collect the lower layer and concentrated with nitrogen gas (N2). After dissolving the concentrated sample in 300 μL of ethanol, the amount of cholesterol was measured using a total cholesterol kit (AM 202-K). 100 μL of sample was added to 1 mL of enzyme reagent, mixed, incubated at 37°C for 5 minutes, and absorbance was measured with an ELISA reader at a wavelength of 500 nm. The cholesterol in the standard solution was set to 3 mg/mL by adding 20uL of the standard solution to 3 mL of enzyme reagent. The results are shown in Table 6.
상기와 같은 실험예를 통하여 벌나무추출물과 함박꽃나무추출물의 최적의 혼합비율을 확인할 수 있었으며, 하기의 처방예를 이용하여 실시예를 수행하였으며 하기에 언급한 제조예에 한정되는 것은 아니다.Through the experimental examples described above, the optimal mixing ratio of bee tree extract and Hambac tree extract could be confirmed, and the examples were performed using the following prescription examples and are not limited to the preparation examples mentioned below.
처방예 1 - 화장수Prescription Example 1 - Toner
혼합추출물을 함유한 화장료 중 화장수의 처방예는 다음 표 7과 같다.Examples of prescriptions for lotions among cosmetics containing mixed extracts are shown in Table 7 below.
(단위:중량%)content
(Unit: weight%)
처방예 2 - 에센스Prescription Example 2 - Essence
혼합추출물을 함유한 화장료중 에센스의 처방예는 다음 표 8과 같다Examples of essence formulations among cosmetics containing mixed extracts are shown in Table 8 below.
(단위:중량%)content
(Unit: weight%)
0.1
실시예 1 - 혼합추출물을 포함하는 화장료의 피지분비 억제 효과Example 1 - Sebum secretion inhibition effect of cosmetics containing mixed extracts
실험은 처방예 2에서 제조한 제형예 5 내지 8과, 상기 처방예 2에서 혼합추출물을 포함하지 않은 비교처방예의 에센스 제형을 이용하여 실험하였으며, 각 그룹은 20대 남녀 20명을 선정하여, A,B,C,D 그룹에는 혼합 추출물이 함유된 제형예 5 내지 8의 에센스를, E 그룹에는 혼합추출물을 포함하지 않은 비교처방예의 에센스를 1일 2회 매일 아침, 저녁 세안 후 4주간 사용하도록 하였다. 피지 측정은 세안 후 30분간 항온, 항습실에서 안정시킨 후 피지측정기(Sebumeter)를 이용하여, 이마의 피지량을 측정하였다. 시험을 위한 크림을 사용하기 전 피지량을 초기값으로 설정하였으며, 해당 유연 화장수를 지속적으로 사용하면서 매주 1회 4주간 피지량의 변화를 측정하였다. 본 발명의 혼합 추출물에 의한 피지량의 변화는 초기 피지량과 비교하여 피지 억제 효능 여부를 판정하였으며, 그 결과는 표 9에 나타내었다.The experiment was conducted using Formulation Examples 5 to 8 prepared in Prescription Example 2 and the essence formulation of the comparative prescription example that did not contain the mixed extract in Prescription Example 2. For each group, 20 men and women in their 20s were selected, A , Groups B, C, and D were to use the essence of Formulation Examples 5 to 8 containing mixed extracts, and group E was to use the essence of Comparative Prescription Examples, which did not contain mixed extracts, twice a day for 4 weeks after washing the face in the morning and evening. did. To measure sebum, the amount of sebum on the forehead was measured using a sebum meter after washing the face and stabilizing it in a constant temperature and humidity room for 30 minutes. Before using the cream for testing, the sebum amount was set to the initial value, and the change in sebum amount was measured once a week for 4 weeks while continuously using the softening lotion. The change in sebum amount caused by the mixed extract of the present invention was compared with the initial sebum amount to determine whether it had sebum suppression effect, and the results are shown in Table 9.
(g/㎠/h)sebum secretion amount
(g/㎠/h)
그룹 AFormulation Example 5
Group A
그룹 BFormulation Example 6
group B
그룹 CFormulation Example 7
Group C
그룹 DFormulation Example 8
group D
그룹 EComparative formulation example
Group E
본 발명의 혼합추출물을 함유하는 제형예는 아무것도 함유하지 않은 비교처방예와 비교하였을 때 시간이 지남에 따라 피지 분비를 효과적으로 감소시켰다. 특히 제형예 6의 제형에서 피지분비 억제 효과가 우수함을 확인할 수 있었다. 따라서, 본 발명의 혼합 추출물은 피지 분비를 효과적으로 감소시킴으로써 피지의 과잉 분비로 인해 여드름 및 기타 세균의 과발현을 방지할 수 있을 것으로 예측된다.The formulation containing the mixed extract of the present invention effectively reduced sebum secretion over time compared to the comparative formulation containing nothing. In particular, it was confirmed that the formulation of Formulation Example 6 had an excellent sebum secretion inhibition effect. Therefore, the mixed extract of the present invention is expected to effectively reduce sebum secretion, thereby preventing the overexpression of acne and other bacteria due to excessive secretion of sebum.
실시예 2 - 혼합 추출물을 함유하는 화장료의 자극완화 효과 Example 2 - Irritation-relieving effect of cosmetics containing mixed extracts
실험은 처방예 2에서 제조한 제형예 5~8 및 비교제형예의 에센스 제형을 이용하여 실시하였으며, 각 그룹은 20대 남녀 20명으로 선정하여, A,B,C,D 그룹에는 혼합추출물이 함유된 제형예 5~8의 에센스를, E 그룹에는 혼합추출물이 함유되지 않은 비교제형예의 에센스을 1일 2회 매일 아침, 저녁 세안 후 4주간 사용하도록 하였다. 평가는 얼굴 양쪽면을 사용하여 4주동안 사용하면서 피부에 나타나는 자극 여부를 평가하였다. 그 결과를 표 10에 나타냈다.The experiment was conducted using the essence formulations of Formulation Examples 5 to 8 and Comparative Formulation Example prepared in Prescription Example 2. Each group was selected with 20 men and women in their 20s, and groups A, B, C, and D contained mixed extracts. The essences of Formulation Examples 5 to 8 were used in Group E, and the essence of Comparative Formulation Example, which did not contain mixed extracts, was used twice a day for 4 weeks after washing the face in the morning and evening every day. The evaluation was conducted on both sides of the face to evaluate whether or not irritation appeared on the skin while using the product for 4 weeks. The results are shown in Table 10.
그룹 AFormulation Example 5
Group A
그룹 BFormulation Example 6
group B
그룹 CFormulation Example 7
Group C
그룹 DFormulation Example 8
group D
그룹 EComparative formulation example
Group E
Claims (8)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020210135722A KR102622690B1 (en) | 2021-10-13 | 2021-10-13 | Cosmetic composition for protecting skin comprising mixed extracts of acer tegmentosum and magnolia sieboldii as active ingredient |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020210135722A KR102622690B1 (en) | 2021-10-13 | 2021-10-13 | Cosmetic composition for protecting skin comprising mixed extracts of acer tegmentosum and magnolia sieboldii as active ingredient |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20230052546A KR20230052546A (en) | 2023-04-20 |
| KR102622690B1 true KR102622690B1 (en) | 2024-01-10 |
Family
ID=86143906
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020210135722A KR102622690B1 (en) | 2021-10-13 | 2021-10-13 | Cosmetic composition for protecting skin comprising mixed extracts of acer tegmentosum and magnolia sieboldii as active ingredient |
Country Status (1)
| Country | Link |
|---|---|
| KR (1) | KR102622690B1 (en) |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004244370A (en) | 2003-02-14 | 2004-09-02 | Pola Chem Ind Inc | External preparation for skin for pimple |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101135172B1 (en) * | 2008-12-22 | 2012-04-19 | 한국원자력연구원 | A composition for the prevention, improvement or treatment of acne vulgaris comprising the mixture of extract of Phellodendron amurense Rupr, Houttuynia cordata, Paeonia lactiflora Pall, Agrimonia pilosa Ledeb, and Glycyrrhiza uralensis Fisch as an effective ingredient |
| KR101619571B1 (en) * | 2013-12-03 | 2016-05-10 | 주식회사 바이오에프디엔씨 | Anti-aging Composition for Skin External Application Comprising Magnolia Placenta Culture Extracts |
| KR20160050262A (en) * | 2014-10-29 | 2016-05-11 | 민 선 김 | Anti-oxidative and anti-inflammatory cosmetic ingredient composition |
| KR20160076126A (en) * | 2014-12-22 | 2016-06-30 | 주식회사 고운선형 | Acne cosmetic treatment that can be prescribed step by step |
| KR20160118417A (en) * | 2015-04-01 | 2016-10-12 | (주)황후연 | Manufacturing Method and Composion for Viper Venom Liquid Mixture |
-
2021
- 2021-10-13 KR KR1020210135722A patent/KR102622690B1/en active IP Right Grant
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004244370A (en) | 2003-02-14 | 2004-09-02 | Pola Chem Ind Inc | External preparation for skin for pimple |
Also Published As
| Publication number | Publication date |
|---|---|
| KR20230052546A (en) | 2023-04-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP3529811B2 (en) | External preparation for skin | |
| KR101393007B1 (en) | Cosmetic Composition for Skin-aging Protection and Wrinkle Improvement Comprising the Extract of Nephelium lappaceum and Litchi chinensis sonn as Active Ingredient | |
| US20080206366A1 (en) | Cosmetic composition comprising extract from mallotus japonicus for improving skin wrinkle | |
| KR101868507B1 (en) | Cosmetic Composition for Anti-oxidation, Anti-inflammatory and Anti-wrinkling Comprising Enzyme-treated Extracts of Annona Muricata and Method for Manufacturing the Same | |
| CN106880561B (en) | Cosmetic composition containing black bamboo extract for regulating skin temperature | |
| KR102040107B1 (en) | Anti-aging composition mixing device | |
| KR102107194B1 (en) | Cosmetic Composition For Preventing Hair Loss Containing Arctium Lappa Seed Extract | |
| WO2002032442A1 (en) | Skin external preparation containing pine pollen or pine pollen extract | |
| KR101415996B1 (en) | Cosmetic composition containing scoria | |
| KR102436798B1 (en) | Methods for manufacturing of coix lacryma-jobi and scoria complex ferment with improved skin sedation and anti-aging effects and cosmetic composition using same | |
| KR101542490B1 (en) | Cosmetic composition comprising the mixed extracts of Achillea, Borage, Helichrysum, Lady's mantle, and Eucalyptus | |
| KR102282645B1 (en) | Cosmetic composition comprising mixed extracts of cnidium officinale and scutellaria baicalensis or compounds seperated from thereof for alleiviating acne and dandruff | |
| KR101974502B1 (en) | Cosmetic composition for anti-allergy and for improving atopic dermatitis comprising extract of anemone reflexa stephan as active ingredient | |
| KR102622690B1 (en) | Cosmetic composition for protecting skin comprising mixed extracts of acer tegmentosum and magnolia sieboldii as active ingredient | |
| KR100858627B1 (en) | Cosmetic Composition for Inhibiting Secretion of Sebum containing Extract of Fritillaria verticillata as Active Ingredient | |
| KR20120038321A (en) | Cosmetic composition using apios and manufacturing method thereof | |
| KR102377447B1 (en) | Suaeda japonica and scoria Complex fermentation product having increased polyphenol content, preparing method the same and cosmetic composition by using the same | |
| KR20190021114A (en) | Composition for anti-inflammation, inhibiting secretion of sebum, or treating acne on the skin comprising plant extract | |
| KR101976725B1 (en) | Cosmetic composition for reducing acne and inhibiting sebum secretion containing extract of prunella vulgaris linne var or compounds separated from the same | |
| KR20190102364A (en) | Anti-aging composition and cosmetic using the same | |
| KR102290424B1 (en) | Cosmetic composition for regulating microbe in skin comprising extract of rosa multiflora thunberg fruit or fractions from thereof | |
| KR20010000390A (en) | Skin Improvement Composition Including Anti-Aging and Anti-Acne with Kimchi Extract | |
| KR101944496B1 (en) | Cosmetic composition for reducing acne and inhibiting sebum secretion containing celastrus orbiculatus extract or compound isolated from it | |
| KR102643752B1 (en) | Cosmetic composition for controlling sebum and improving pore comprising fermentation product of primula veris | |
| KR101131685B1 (en) | Cosmetic compositions having sebosuppressive effect |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| E902 | Notification of reason for refusal | ||
| E701 | Decision to grant or registration of patent right |