KR102516108B1 - Granule royal jelly composition and method for thereof - Google Patents
Granule royal jelly composition and method for thereof Download PDFInfo
- Publication number
- KR102516108B1 KR102516108B1 KR1020200074237A KR20200074237A KR102516108B1 KR 102516108 B1 KR102516108 B1 KR 102516108B1 KR 1020200074237 A KR1020200074237 A KR 1020200074237A KR 20200074237 A KR20200074237 A KR 20200074237A KR 102516108 B1 KR102516108 B1 KR 102516108B1
- Authority
- KR
- South Korea
- Prior art keywords
- royal jelly
- honey
- granular
- present
- freeze
- Prior art date
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- A—HUMAN NECESSITIES
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Abstract
본 발명의 과립형 로열젤리는 로열젤리의 맛을 개선시키고 섭취하기 불편했던 꿀의 기호도를 증진시키며, 로열젤리와 꿀이 가지는 건강상 이점의 동시 제공이 가능하여 이를 제품화하여 일반에 공급함으로써 식품, 건강기능 식품, 화장품, 의약품 분야에 다양하게 활용 가능하다.The granular royal jelly of the present invention improves the taste of royal jelly, enhances the preference of honey, which was inconvenient to consume, and can simultaneously provide the health benefits of royal jelly and honey, so that it can be commercialized and supplied to the general public, thereby providing food, It can be used in various fields such as health functional foods, cosmetics, and pharmaceuticals.
Description
본 발명은 과립형 로열젤리 조성물 및 그의 제조방법에 관한 것이다.The present invention relates to a granular royal jelly composition and a method for preparing the same.
로열젤리(rowal jelly)는 여왕벌의 음식물로써 일벌의 입으로부터 제공된다. 일벌은 꽃가루와 꿀을 주식으로 하고 있는데, 소화 및 흡수된 영양소가 혈관을 통해 머리에 있는 인두선에 운반되어 로열젤리로 저장된 후 여왕벌에게 공급되는 것이다.Royal jelly is the food of the queen bee and is provided from the mouths of the worker bees. Worker bees have pollen and nectar as their staple food, and digested and absorbed nutrients are transported through blood vessels to the pharyngeal gland on the head, stored as royal jelly, and then supplied to the queen bee.
꿀벌의 알은 부화된 후 처음 3일간은 모두 로열젤리를 먹으나, 그 다음 3일간은 로열젤리를 계속해서 먹으면 여왕벌이되고, 꿀과 꽃가루를 먹으면 일벌이 된다. 즉, 3일간의 먹이에 따라 불과 40~60일밖에 살지 못하는 일벌이 되기도 하고, 일벌에 비해 몸집이 2배 이상 크며 일생에 약 300만 개의 알을 낳는 능력을 갖고 3~5년까지 장수하는 여왕벌이 되기도 한다. 이로 인해 로열젤리가 불로장생, 강정의 영약, 영원한 젊음을 제공하는 신의 음식, 만능의 자연식품 등으로 불리는 것이다.Bee eggs eat royal jelly for the first 3 days after hatching, but if they continue to eat royal jelly for the next 3 days, they become queen bees, and if they eat nectar and pollen, they become worker bees. In other words, depending on the food for 3 days, it becomes a worker bee that lives only 40 to 60 days, and the queen bee, which is more than twice as large as the worker bee and has the ability to lay about 3 million eggs in a lifetime and lives up to 3 to 5 years may become Because of this, royal jelly is called eternal youth, elixir of strength, divine food that provides eternal youth, and all-around natural food.
로열젤리는 영양보급, 건강증진 및 유지에 도움이 되는 고단백 식품으로, 양질의 단백질과 지방산, 각종 비타민, 무기질 등 40여 종의 생리활성 물질을 함유하고 있다. 로열젤리는 생체 저항력 강화 및 성장촉진 작용, 항암 작용, 항균 작용, 내분비·순환계통·조혈기관 등에 영향을 준다. 또한, 노약자의 건강 유지, 고령자의 식욕 부진, 신경증 환자에 효과가 있으며, 혈중 콜레스테롤 수치를 낮추기 때문에 동맥경화 예방에도 좋다. 또한, 신경장애 특히 우울증 환자에게 도움이 되고, 수술 후 회복기 환자에도 좋다. 로열젤리에는 타액선 호르몬인 파로틴(parotin)과 유사물질이 다량 함유되어 있어 노화 방지에 효과가 있는 것으로 알려졌다. 다만, 로열젤리는 특유의 비릿한 맛과 향으로 인해 소비자 기호도가 낮은 문제가 있다.Royal jelly is a high-protein food that is helpful in replenishing nutrition and promoting and maintaining health. Royal jelly strengthens biological resistance and promotes growth, anticancer activity, antibacterial activity, and affects the endocrine, circulatory, and hematopoietic organs. In addition, it is effective for maintaining the health of the elderly, anorexia of the elderly, and patients with neurosis, and it is also good for preventing arteriosclerosis because it lowers blood cholesterol levels. In addition, it is helpful for patients with neurological disorders, especially depression, and is also good for patients recovering from surgery. Royal jelly is known to be effective in preventing aging because it contains a large amount of parotin, a salivary gland hormone, and similar substances. However, royal jelly has a problem of low consumer preference due to its unique fishy taste and aroma.
한편, 벌꿀은 꿀벌이 초목 꽃의 꿀샘으로부터 꽃꿀을 모아, 겨울의 먹이로서 보금자리 가운데 저장한 것으로, 백색, 담황색, 황적색 또는 짙은 색을 띠고 단맛이 강한 점성의 투명한 진한 액으로, 저온에서는 결정이 생겨 뿌옇게 된다. 성분의 대부분은 당분(80% 전후)이다. 꽃꿀의 당분은 40% 정도이고, 자당을 주로하고 있지만, 벌꿀에는 꿀벌의 잎으로부터 분비되는 β-프룩토푸라노시다아제(β-fructofuranosidase)와 혼합되어 벌집에서 숙성 중에 글루코오스와 프룩토오스로 변환된다.On the other hand, honey is what bees collect flower nectar from the nectar glands of plant flowers and store in nests as winter food. It is white, light yellow, yellowish red or dark in color and is a viscous, transparent thick liquid with strong sweetness. At low temperatures, it crystallizes. arises and becomes cloudy. Most of the ingredients are sugar (around 80%). The sugar content of flower nectar is about 40%, mainly sucrose, but honey is mixed with β-fructofuranosidase secreted from bee leaves and converted to glucose and fructose during maturation in the hive. do.
당분은 보통 프룩토오스 50%, 글루코오스 40% 정도로, 자당은 불과 몇%에 지나지 않고, 그외 맥아당 등을 소량 함유한다. 이외에 유기산으로서 포름산, 락트산, 말산을 포함하고, 고무질, 왁스질물 등을 소량 함유하고 있다. 꽃의 종류에 따라 맛에 특징이 있고, 프룩토오스를 다량 함유하기 때문에 비결정성이며, 공기 중의 수분을 흡수하는 성질이 있기 때문에 식품 건조에 의한 변질을 막는다. 또 설사제로서 약용에 이용되고 있기도 하다.Sugar is usually about 50% fructose, 40% glucose, sucrose is only a few%, and contains small amounts of other maltose and the like. In addition, organic acids include formic acid, lactic acid, and malic acid, and contain small amounts of rubbery and waxy substances. Depending on the type of flower, the taste is characteristic, and since it contains a large amount of fructose, it is amorphous and absorbs moisture in the air, so it prevents deterioration due to drying of food. It is also used medicinally as a laxative.
또한, 벌꿀은 보중익기(비장과 위장의 기능을 보하여 기를 만들어 보함), 윤폐지해(폐를 촉촉하게 적셔주고 기침을 멈춤), 해독료창(독소를 제거하고 종기를 가라앉힘), 완급지통(급한 기운을 완화시키고 통증을 멈춤), 활장통변(대장을 윤택하게 하여 대변이 잘나오게 함), 조화제약(모든 약을 조화롭게 함), 허리소기(산후에 기가 부족해 허약하고 야위어짐), 폐조해수(폐나 기관지의 진액이 마르고 건조해져 기침이 남), 장조변비(장의 진액이 부족하여 대변이 굳어짐), 완복동통(복부가 아픔), 구창(구내염), 궤양피염(피부나 점막이 짓무르는 피부병), 탕화상(끓는 물이나 불에 데인 상처), 오두독(한약재 오두의 중독) 등의 효능이 알려졌다.In addition, honey is effective in bojungikgi (boosts spleen and stomach functions to make qi), yunpyejihae (moisturizes the lungs and stops coughing), detoxifying lyochang (removes toxins and soothes boils), and mitigates pain (Relieves acute energy and stops pain), Bowel pain (enriches the large intestine and makes the stool come out well), harmonization medicine (harmonizes all medicines), waist small (weak and thin due to lack of energy after childbirth), lung Deliquescence (coughing due to dryness of lung or bronchial fluid), intestinal constipation (hard stool due to lack of intestinal fluid), sarcopenia (pain in the abdomen), mouth ulcer (stomatitis), ulcerative dermatitis (sore skin or mucous membranes) skin disease), tang burns (burned wounds from boiling water or fire), and odoudok (poisoning of Chinese herbal medicine ohdu).
다만, 꿀은 천연상태 또는 인공으로 양봉한 상태에서 채취하여 통상 액상의 형태로 상품화가 이루어지고 있으나, 상품의 제형상 꿀이 보유하고 있는 다양한 효능에도 불구하고 그 이용에 한계가 있다. 즉, 액상 형태의 꿀은 그 보관을 위해서는 액상의 저장용기가 필요하며, 그 사용상, 장기보존의 필요성에도 불구하고 내재하고 있는 물리적인 특성으로 인하여 취급상 각별한 주의가 요망되어, 구체적인 상품화에 많은 한계가 있다.However, honey is harvested in a natural or artificially beekeeping state and commercialized in the form of a liquid, but despite the various efficacies of honey in the form of a product, there are limits to its use. In other words, honey in liquid form requires a liquid storage container for its storage, and despite the need for long-term preservation, special attention is required in handling due to its inherent physical characteristics, so there are many limitations in specific commercialization. there is
이에, 로열젤리의 맛과 향에 대한 기호성을 증진시키고, 꿀의 불편한 섭취방법의 개선이 필요한 실정이다.Accordingly, it is necessary to improve the palatability of the taste and aroma of royal jelly and to improve the inconvenient intake method of honey.
본 발명자는 로열젤리와 꿀을 포함하는 조성물을 과립형으로 제조함으로써, 로열젤리의 맛을 개선시키고 섭취하기 불편했던 꿀의 기호도를 증진시킬 수 있었다.The present inventors were able to improve the taste of royal jelly and enhance the preference of honey, which was inconvenient to consume, by preparing a composition containing royal jelly and honey in granular form.
따라서, 본 발명의 하나의 목적은 과립형 로열젤리의 제조방법 및 이의 방법으로 제조된 과립형 로열젤리를 제공하는 것이다.Accordingly, one object of the present invention is to provide a method for preparing granular royal jelly and a granular royal jelly prepared by the method.
본 발명의 또 다른 목적은 본 발명의 과립형 로열젤리를 포함하는 식품 조성물, 식품 보조제 및 화장료 조성물을 제공하는 것이다.Another object of the present invention is to provide a food composition, food supplement and cosmetic composition containing the granular royal jelly of the present invention.
본 발명은 (a) 로열젤리를 동결건조하는 단계; (b) 상기 (a) 단계에서 동결건조된 로열젤리 및 벌꿀을 혼합하는 단계; 및 (c) 상기 (b) 단계의 혼합물을 열풍건조하는 단계;를 포함하는 과립형 로열젤리의 제조방법을 제공한다.The present invention comprises the steps of (a) freeze-drying royal jelly; (b) mixing the freeze-dried royal jelly and honey in step (a); and (c) drying the mixture of step (b) with hot air.
본 발명의 과립형 로열젤리 제조방법에 있어, 상기 단계 (a)의 동결건조는, 바람직하게 -80 ~ -10℃에서 12~72시간 동안 수행되는 것이 좋다.In the granular royal jelly manufacturing method of the present invention, the freeze-drying in step (a) is preferably performed at -80 to -10 ° C for 12 to 72 hours.
본 발명의 과립형 로열젤리 제조방법에 있어, 상기 단계 (b)의 혼합은, 바람직하게 로열젤리와 벌꿀이 1~5 : 1~5의 중량비율로 혼합된 것이 좋다.In the granular royal jelly manufacturing method of the present invention, the mixing in step (b) is preferably a mixture of royal jelly and honey in a weight ratio of 1 to 5: 1 to 5.
본 발명의 과립형 로열젤리 제조방법에 있어, 상기 단계 (b)의 혼합은, 바람직하게 덱스트린을 더 포함하는 것이 좋다. 이때, 상기 혼합은, 바람직하게 로열젤리, 덱스트린, 벌꿀이 1~5 : 0.5~2 : 1~5의 중량비율로 혼합된 것이 좋다.In the granular royal jelly manufacturing method of the present invention, the mixing in step (b) preferably further includes dextrin. At this time, the mixture is preferably mixed with royal jelly, dextrin, and honey in a weight ratio of 1 to 5: 0.5 to 2: 1 to 5.
본 발명의 과립형 로열젤리 제조방법에 있어, 상기 (b) 단계의 벌꿀은, 일 예로 아카시아꿀, 밤꿀, 헛개나무꿀 및 잡화꿀 중 선택되는 어느 하나일 수 있다.In the granular royal jelly manufacturing method of the present invention, the honey in step (b) may be, for example, any one selected from acacia honey, chestnut honey, hovenia honey and miscellaneous honey.
본 발명의 과립형 로열젤리 제조방법에 있어, 상기 단계 (c)의 열풍건조는, 바람직하게 30~50℃에서 1~4시간 동안 수행되는 것이 좋다.In the granular royal jelly manufacturing method of the present invention, the hot air drying in step (c) is preferably performed at 30 to 50 ° C. for 1 to 4 hours.
본 발명은 (a) 로열젤리를 동결건조하는 단계; (b) 상기 (a) 단계에서 동결건조된 로열젤리 및 벌꿀을 혼합하는 단계; 및 (c) 상기 (b) 단계의 혼합물을 열풍건조하는 단계;를 포함하는 방법으로 제조된 과립형 로열젤리를 제공한다.The present invention comprises the steps of (a) freeze-drying royal jelly; (b) mixing the freeze-dried royal jelly and honey in step (a); and (c) drying the mixture of step (b) with hot air.
본 발명은 본 발명의 로열젤리를 포함하는 식품 조성물을 제공한다. 이때, 상기 식품 조성물은, 바람직하게 헬리코박터균 억제용 또는 피부재생용인 것이 좋다.The present invention provides a food composition comprising the royal jelly of the present invention. At this time, the food composition is preferably for inhibiting Helicobacter pylori or for skin regeneration.
본 발명은 본 발명의 로열젤리를 포함하는 건강 보조제를 제공한다. 이때, 상기 건강 보조제는, 바람직하게 헬리코박터균 억제용 또는 피부재생용인 것이 좋다.The present invention provides a health supplement comprising the royal jelly of the present invention. At this time, the health supplement is preferably for inhibiting Helicobacter pylori or for skin regeneration.
본 발명은 본 발명의 로열젤리를 포함하는 화장료 조성물을 제공한다. 이때, 상기 화장료 조성물은, 바람직하게 피부재생용 또는 상처치료용인 것이 좋다.The present invention provides a cosmetic composition comprising the royal jelly of the present invention. At this time, the cosmetic composition is preferably for skin regeneration or wound treatment.
본 발명의 과립형 로열젤리는 로열젤리의 맛을 개선시키고 섭취하기 불편했던 꿀의 기호도를 증진시키며, 로열젤리와 꿀이 가지는 건강상 이점의 동시 제공이 가능하여 이를 제품화하여 일반에 공급함으로써 식품, 건강기능 식품, 화장품, 의약품 분야에 다양하게 활용 가능하다.The granular royal jelly of the present invention improves the taste of royal jelly, enhances the preference of honey, which was inconvenient to consume, and can simultaneously provide the health benefits of royal jelly and honey, so that it can be commercialized and supplied to the general public, thereby providing food, It can be used in various fields such as health functional foods, cosmetics, and pharmaceuticals.
도 1은 본 발명 과립형 로열젤리의 제조과정을 나타낸 도이다.
도 2는 본 발명 과립형 로열젤리의 피부세포 증식 효능을 평가한 결과이다.
도 3은 본 발명 과립형 로열젤리의 피부세포 이주 효능을 평가한 결과이다.
도 4는 본 발명 과립형 로열젤리의 헬리코박터균 억제 효능을 평가한 결과이다.1 is a diagram showing the manufacturing process of the granular royal jelly of the present invention.
Figure 2 is the result of evaluating the skin cell proliferation efficacy of the granular royal jelly of the present invention.
Figure 3 is the result of evaluating the skin cell migration efficacy of the granular royal jelly of the present invention.
Figure 4 is the result of evaluating the Helicobacter pylori inhibitory efficacy of the granular royal jelly of the present invention.
피부건강 및 면역력 증강에 효과가 좋은 로열젤리는 특유의 비릿한 맛과 향으로 인해 소비자 기호도가 낮은 반면, 벌꿀은 맛과 향은 우수하나 섭취방법이 용이하지 않아 일상에서 소비확대가 어려운 문제가 있어왔다.Royal jelly, which is effective for skin health and immunity enhancement, has low consumer preference due to its unique fishy taste and aroma, while honey has excellent taste and aroma, but it is not easy to consume, making it difficult to expand consumption in everyday life. .
이에, 본 발명자는 로열젤리의 맛과 향의 기호도를 증진하고, 꿀의 휴대와 복용의 간편함을 만족시키며, 꿀과 로열젤리의 효능을 동시 제공 가능한 방법을 연구하던 중 과립형 로열젤리를 개발하였다.Accordingly, the present inventor developed granular royal jelly while researching a method that can improve the taste and aroma of royal jelly, satisfy the convenience of carrying and taking honey, and provide the efficacy of honey and royal jelly at the same time. .
따라서, 본 발명은 (a) 로열젤리를 동결건조하는 단계; (b) 상기 (a) 단계에서 동결건조된 로열젤리 및 벌꿀을 혼합하는 단계; 및 (c) 상기 (b) 단계의 혼합물을 열풍건조하는 단계;를 포함하는 과립형 로열젤리의 제조방법을 제공한다.Therefore, the present invention comprises the steps of (a) freeze-drying royal jelly; (b) mixing the freeze-dried royal jelly and honey in step (a); and (c) drying the mixture of step (b) with hot air.
본 발명의 과립형 로열젤리 제조방법에 있어, 상기 단계 (a)의 동결건조는, 바람직하게 -80 ~ -10℃에서 12~72시간 동안 수행되는 것이 좋다. -80℃, 12시간 미만으로 동결건조를 수행하면 로열젤리의 일부가 완전히 냉동되지 못하며, -10℃, 72시간을 초과하여 동결건조를 수행하면 건조 시간이 길어져 전기세 및 수수료 등의 인상으로 경제적인 부담이 크기 때문이다.In the granular royal jelly manufacturing method of the present invention, the freeze-drying in step (a) is preferably performed at -80 to -10 ° C for 12 to 72 hours. If freeze-drying is performed at -80℃ for less than 12 hours, part of the royal jelly cannot be completely frozen, and when freeze-drying is performed for more than 72 hours at -10℃, the drying time becomes longer, resulting in an economical increase in electricity bills and fees. because the burden is great.
본 발명의 과립형 로열젤리 제조방법에 있어, 상기 단계 (b)의 혼합은, 바람직하게 로열젤리와 벌꿀이 1~5 : 1~5의 중량비율로 혼합된 것이 좋으며, 더욱 바람직하게는 동일 중량비율로 혼합된 것이 좋다. 본 발명의 바람직한 구현예에서는 로열젤리와 벌꿀을 1 : 1의 중량비율로 혼합하여 사용하였다. 로열젤리의 중량비가 높아지면 로열젤리 특유의 비린한 맛과 향이 강해 섭취에 거부감이 생기기 쉽고, 벌꿀의 중량비가 높아지면 섭취가 용이하지 않아 불편하기 때문이다. 또한, 해당 중량비에서 벌꿀과 로열젤리의 시너지 효과가 가장 우수하였음을 확인한바 있기 때문이다.In the granular royal jelly manufacturing method of the present invention, the mixing in step (b) is preferably a mixture of royal jelly and honey in a weight ratio of 1 to 5: 1 to 5, more preferably the same weight Mixed in proportion is good. In a preferred embodiment of the present invention, royal jelly and honey were mixed in a weight ratio of 1:1. This is because when the weight ratio of royal jelly increases, the fishy taste and aroma unique to royal jelly are strong, making it easy to feel repulsive in intake, and when the weight ratio of honey increases, intake is not easy and inconvenient. In addition, this is because it was confirmed that the synergistic effect of honey and royal jelly was the best in the weight ratio.
본 발명의 과립형 로열젤리 제조방법에 있어, 상기 단계 (b)의 혼합은, 바람직하게 덱스트린을 더 포함하는 것이 좋다. 이때, 상기 혼합은, 바람직하게 로열젤리, 덱스트린, 벌꿀이 1~5 : 0.5~2 : 1~5의 중량비율로 혼합된 것이 좋고, 더욱 바람직하게는 5 : 1 : 5의 중량비율로 혼합된 것이 좋다. 덱스트린의 중량비가 높아지면 로열젤리와 벌꿀의 함량이 상대적으로 줄어들게 되어 로열젤리와 벌꿀의 시너지 효과를 기대하기 어렵고, 해당 중량비가 과립형 로열젤리의 맛을 해치지 않으면서 과립화에 적합하기 때문이다.In the granular royal jelly manufacturing method of the present invention, the mixing in step (b) preferably further includes dextrin. At this time, the mixing is preferably mixed with royal jelly, dextrin, and honey in a weight ratio of 1 to 5: 0.5 to 2: 1 to 5, more preferably 5: 1: mixed in a weight ratio of 5 It is good. This is because when the weight ratio of dextrin increases, the content of royal jelly and honey is relatively reduced, making it difficult to expect a synergistic effect between royal jelly and honey, and the weight ratio is suitable for granulation without compromising the taste of granular royal jelly.
즉, 과립화를 위해서는 벌꿀 함량이 높을 경우 덱스트린 함량도 높아져야하는데, 덱스트린 함량이 높아지면 로열젤리와 벌꿀의 시너지 효과를 기대하기 어렵기 때문에 가능한 덱스트린의 양을 낮추기 위하여 벌꿀 함량의 상한을 동결건조 로열젤리 양으로 설정하는 것이 바람직하였다. 따라서, 본 발명의 일 실시예에 의하면, 로열젤리 특유의 비릿한 맛과 향을 제거할 수 있는 벌꿀의 최소함량을 조건으로 할 경우, 로열젤리, 덱스트린, 벌꿀이 5 : 1 : 5의 중량비율로 혼합된 것이 가장 적합하였다.In other words, for granulation, if the honey content is high, the dextrin content must also be increased. If the dextrin content is high, it is difficult to expect a synergistic effect between royal jelly and honey. It was preferable to set it by the amount of jelly. Therefore, according to one embodiment of the present invention, when the condition is the minimum content of honey capable of removing the fishy taste and aroma peculiar to royal jelly, royal jelly, dextrin, and honey are mixed in a weight ratio of 5: 1: 5 A mixture was most suitable.
본 발명의 과립형 로열젤리 제조방법에 있어, 상기 (b) 단계의 벌꿀은, 일 예로 아카시아꿀, 밤꿀, 헛개나무꿀 및 잡화꿀 중 선택되는 어느 하나일 수 있다. 벌꿀은 액상의 벌꿀을 그대로 사용하여도 무방하며, 벌꿀의 종류는 아카시아꿀, 벌꿀, 헛개나무꿀, 잡화꿀 등 그 종류에 제한을 두지 않는다. 벌꿀의 종류에 따라 색상이 달라지므로 기호에 따라 벌꿀 종류를 선택할 수 있으며, 벌꿀의 종류에 따라 효능을 갖는 영역이 상이하므로 원하는 효능 부여를 위하여 벌꿀의 종류를 특정할 수 있다.In the granular royal jelly manufacturing method of the present invention, the honey in step (b) may be, for example, any one selected from acacia honey, chestnut honey, hovenia honey and miscellaneous honey. It is okay to use liquid honey as it is, and the type of honey is not limited to acacia honey, honey, barn tree honey, and miscellaneous honey. Since the color varies depending on the type of honey, you can select the type of honey according to your preference, and since the area having efficacy is different depending on the type of honey, the type of honey can be specified to give the desired effect.
본 발명의 과립형 로열젤리 제조방법에 있어, 상기 단계 (c)의 열풍건조는, 바람직하게 30~50℃에서 1~4시간 동안 수행되는 것이 좋다. 30℃, 1시간 미만으로 열풍건조를 수행하면 과립형 로열젤리가 완전히 건조되지 않아 바람직하지 못하고, 50℃, 4시간을 초과하여 열풍건조를 수행하면 본 발명 과립형 로열젤리가 가지는 기능성 성분이 파괴되어 바람직하지 못하기 때문이다.In the granular royal jelly manufacturing method of the present invention, the hot air drying in step (c) is preferably performed at 30 to 50 ° C. for 1 to 4 hours. If hot air drying is performed at 30°C for less than 1 hour, the granular royal jelly is not completely dried, which is undesirable, and when hot air drying is performed for more than 4 hours at 50°C, the functional components of the granular royal jelly of the present invention are destroyed. because it is not desirable.
한편, 본 발명은 (a) 로열젤리를 동결건조하는 단계; (b) 상기 (a) 단계에서 동결건조된 로열젤리 및 벌꿀을 혼합하는 단계; 및 (c) 상기 (b) 단계의 혼합물을 열풍건조하는 단계;를 포함하는 방법으로 제조된 과립형 로열젤리를 제공한다On the other hand, the present invention comprises the steps of (a) freeze-drying royal jelly; (b) mixing the freeze-dried royal jelly and honey in step (a); and (c) drying the mixture of step (b) with hot air.
본 발명의 일 실시예에서는 본 발명의 과립형 로열젤리를 이용하여, 피부세포 증식 효능이 있는 로열젤리와 헬리코박터균 억제 효능을 갖는 벌꿀의 시너지 효과를 확인한 바 있다. 즉, 본 발명의 과립형 로열젤리는 피부세포 증식, 피부상처재생 및 헬리코박터 억제 효능이 매우 우수한 것을 특징으로 한다.In one embodiment of the present invention, using the granular royal jelly of the present invention, the synergistic effect of royal jelly having skin cell proliferation effect and honey having Helicobacter pylori inhibitory effect was confirmed. That is, the granular royal jelly of the present invention is characterized by excellent skin cell proliferation, skin wound regeneration, and Helicobacter pylori inhibitory effects.
따라서, 본 발명은 본 발명의 로열젤리를 포함하는 식품 조성물을 제공한다. 이때, 상기 식품 조성물은, 바람직하게 헬리코박터균 억제용 또는 피부재생용인 것이 좋다.Accordingly, the present invention provides a food composition comprising the royal jelly of the present invention. At this time, the food composition is preferably for inhibiting Helicobacter pylori or for skin regeneration.
본 발명의 식품 조성물에 있어, 상기 과립형 로열젤리는 바람직하게 식품 조성물 대비 0.00001~50 중량% 포함되는 것이 좋다. 0.00001 중량% 미만일 경우에는 그 효과가 미비하고, 50 중량%를 초과하는 경우에는 사용량 대비 효과 증가가 미미하여 비경제적이다.In the food composition of the present invention, the granular royal jelly is preferably included in an amount of 0.00001 to 50% by weight compared to the food composition. If it is less than 0.00001% by weight, the effect is insufficient, and if it exceeds 50% by weight, the increase in effect compared to the amount used is insignificant, which is uneconomical.
본 발명의 식품 조성물은 일 예로 육류, 곡류, 카페인 음료, 일반음료, 초콜릿, 빵류, 스낵류, 과자류, 사탕, 피자, 젤리, 면류, 껌류, 유제품류, 아이스크림류, 알코올성 음료, 술, 비타민 복합제 및 그 밖의 건강보조식품류 중 선택되는 어느 하나일 수 있으나, 반드시 이에 한정되는 것은 아니다.The food composition of the present invention is, for example, meat, grains, caffeinated beverages, general beverages, chocolates, breads, snacks, confectionery, candies, pizza, jellies, noodles, gums, dairy products, ice creams, alcoholic beverages, alcohol, vitamin complexes, and It may be any one selected from other health supplements, but is not necessarily limited thereto.
본 발명은 본 발명의 로열젤리를 포함하는 건강 보조제를 제공한다. 이때, 상기 건강 보조제는, 바람직하게 헬리코박터균 억제용 또는 피부재생용인 것이 좋다.The present invention provides a health supplement comprising the royal jelly of the present invention. At this time, the health supplement is preferably for inhibiting Helicobacter pylori or for skin regeneration.
상기 "건강 보조제"는 "건강기능식품"과 동일한 의미로 이해할 수 있는데, 건강기능식품이라 함은 건강기능식품에 관한 법률 제6727호에 따른 인체에 유용한 기능성을 가진 원료나 성분을 사용하여 제조 및 가공한 식품을 의미하며, "기능성"이라 함은 인체의 구조 및 기능에 대하여 영양소를 조절하거나 생리학적 작용 등과 같은 보건 용도에 유용한 효과를 얻을 목적으로 섭취하는 것을 의미한다.The "health supplement" can be understood as the same meaning as "health functional food", and health functional food refers to manufacturing and It refers to processed food, and "functional" refers to intake for the purpose of obtaining useful effects for health purposes such as adjusting nutrients for the structure and function of the human body or physiological functions.
본 발명의 건강 보조제는 통상 사용되어 냄새, 맛, 시각 등을 향상시킬 수 있는 추가 성분을 포함할 수 있다. 예들 들어, 비타민 A, C, D, E, B1, B2, B6, B12, 니아신(niacin), 비오틴(biotin), 폴레이트(folate), 판토텐산(panthotenic acid) 등을 포함할 수 있다. 또한, 아연(Zn), 철(Fe), 칼슘(Ca), 크롬(Cr), 마그네슘(Mg), 망간(Mn), 구리(Cu) 등의 미네랄을 포함할 수 있다. 또한, 라이신, 트립토판, 시스테인, 발린 등의 아미노산을 포함할 수 있다. 또한, 방부제(소르빈산 칼륨, 벤조산나트륨, 살리실산, 디히드로초산나트륨 등), 살균제(표백분과 고도 표백분, 차아염소산나트륨 등), 산화방지제(부틸히드록시아니졸(BHA), 부틸히드록시톨루엔(BHT) 등), 착색제(타르색소 등), 발색제(아질산 나트륨, 아초산 나트륨 등), 표백제(아황산나트륨), 조미료(MSG 글루타민산나트륨 등), 감미료(둘신, 사이클레메이트, 사카린, 나트륨 등), 향료(바닐린, 락톤류 등), 팽창제(명반, D-주석산수소칼륨 등), 강화제, 유화제, 증점제(호료), 피막제, 검기초제, 거품억제제, 용제, 개량제 등의 식품 첨가물(food additives)을 첨가할 수 있다. 상기 첨가물은 보조제의 종류에 따라 선별되고 적절한 양으로 사용될 수 있다.The health supplements of the present invention may contain additional ingredients that are commonly used to improve smell, taste, sight, and the like. For example, vitamins A, C, D, E, B1, B2, B6, B12, niacin, biotin, folate, panthotenic acid, and the like may be included. In addition, minerals such as zinc (Zn), iron (Fe), calcium (Ca), chromium (Cr), magnesium (Mg), manganese (Mn), and copper (Cu) may be included. In addition, amino acids such as lysine, tryptophan, cysteine, and valine may be included. In addition, preservatives (potassium sorbate, sodium benzoate, salicylic acid, sodium dihydroacetate, etc.), disinfectants (bleaching powder, high bleaching powder, sodium hypochlorite, etc.), antioxidants (butylhydroxyanisole (BHA), butylhydroxytoluene (BHT) ), etc.), coloring agents (tar color, etc.), coloring agents (sodium nitrite, sodium nitrite, etc.), bleaching agents (sodium sulfite, etc.), seasonings (MSG sodium glutamate, etc.), sweeteners (dulcin, cyclemate, saccharin, sodium, etc.), Food additives such as flavoring (vanillin, lactones, etc.), leavening agent (alum, D-potassium hydrogentartrate, etc.), strengthening agent, emulsifier, thickener (thickener), coating agent, gum base agent, foam inhibitor, solvent, improver, etc. can be added. The additives may be selected according to the type of adjuvant and used in an appropriate amount.
본 발명의 건강 보조제에 있어서, 과립형 로열젤리의 함량은 특별히 제한되지 않으며, 투여 대상의 상태, 구체적인 병증의 종류, 진행 정도 등에 따라 다양하게 변경될 수 있다. 필요한 경우, 건강 보조제의 전체 함량으로도 포함될 수 있다.In the health supplement of the present invention, the content of granular royal jelly is not particularly limited, and may be variously changed depending on the condition of the subject to be administered, the type of specific disease, and the degree of progression. If necessary, it can also be included in the total amount of dietary supplements.
본 발명은 본 발명의 로열젤리를 포함하는 화장료 조성물을 제공한다. 이때, 상기 화장료 조성물은, 바람직하게 피부재생용 또는 상처치료용인 것이 좋다.The present invention provides a cosmetic composition comprising the royal jelly of the present invention. At this time, the cosmetic composition is preferably for skin regeneration or wound treatment.
본 발명의 화장료 조성물에 포함되는 성분은 유효성분으로서 본 발명의 과립형 로열젤리 이외에 화장료 조성물에 통상적으로 이용되는 성분들을 포함할 수 있으며, 예컨대 항산화제, 안정화제, 용해화제, 비타민, 안료 및 향료와 같은 통상적인 보조제, 그리고 담체를 포함한다.Ingredients included in the cosmetic composition of the present invention may include ingredients commonly used in cosmetic compositions other than the granular royal jelly of the present invention as an active ingredient, such as antioxidants, stabilizers, solubilizers, vitamins, pigments and fragrances and conventional adjuvants such as, and carriers.
본 발명의 화장료 조성물은 당업계에서 통상적으로 제조되는 어떠한 제형으로도 제조될 수 있으며, 예를 들어, 용액, 현탁액, 유탁액, 페이스트, 겔, 크림, 로션, 파우더, 비누, 계면활성제-함유 클렌징, 오일, 분말 파운데이션, 유탁액 파운데이션, 왁스 파운데이션, 팩, 마사지크림 및 스프레이 등으로 제형화될 수 있으나, 이에 한정되는 것은 아니다. 보다 상세하게는, 유연 화장수, 영양 화장수, 영양 크림, 마사지크림, 에센스, 아이 크림, 클렌징 크림, 클렌징 폼, 클렌징 워터, 팩, 스프레이 또는 파우더의 제형으로 제조될 수 있다.The cosmetic composition of the present invention can be prepared in any formulation conventionally prepared in the art, for example, a solution, suspension, emulsion, paste, gel, cream, lotion, powder, soap, surfactant-containing cleansing , It may be formulated into oil, powder foundation, emulsion foundation, wax foundation, pack, massage cream and spray, etc., but is not limited thereto. More specifically, it may be prepared in the form of softening lotion, nutrient lotion, nutrient cream, massage cream, essence, eye cream, cleansing cream, cleansing foam, cleansing water, pack, spray or powder.
본 발명의 화장료 조성물의 제형이 페이스트, 크림 또는 겔인 경우에는 담체 성분으로서 동물성유, 식물성유, 왁스, 파라핀, 전분, 트라칸트, 셀룰로오스 유도체, 폴리에틸렌 글리콜, 실리콘, 벤토나이트, 실리카, 탈크 또는 산화아연 등이 이용될 수 있다.When the formulation of the cosmetic composition of the present invention is a paste, cream or gel, animal oil, vegetable oil, wax, paraffin, starch, tracanth, cellulose derivative, polyethylene glycol, silicone, bentonite, silica, talc or zinc oxide as a carrier component this can be used
본 발명의 화장료 조성물의 제형이 용액 또는 유탁액인 경우에는 담체 성분으로서 용매, 용해화제 또는 유탁화제가 이용되고, 예컨대 물, 에탄올, 이소프로판올, 에틸 카보네이트, 에틸 아세테이트, 벤질 알코올, 벤질 벤조에이트, 프로필렌글리콜, 1,3-부틸글리콜 오일, 글리세롤 지방족 에스테르, 폴리에틸렌글리콜 또는 소르비탄의 지방산 에스테르가 있다.When the formulation of the cosmetic composition of the present invention is a solution or emulsion, a solvent, solubilizing agent or emulsifying agent is used as a carrier component, such as water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene fatty acid esters of glycol, 1,3-butyl glycol oil, glycerol aliphatic esters, polyethylene glycol or sorbitan.
본 발명의 화장료 조성물의 제형이 현탁액인 경우에는 담체 성분으로서 물, 에탄올 또는 프로필렌글리콜과 같은 액상의 희석제, 에톡실화 이소스테아릴 알코올, 폴리옥시에틸렌 소르비톨 에스테르 및 폴리옥시에틸렌 소르비탄 에스테르와 같은 현탁제, 미소 결정성 셀룰로오스, 알루미늄 메타히드록시드, 벤토나이트, 아가 또는 트라칸트 등이 이용될 수 있다.When the formulation of the cosmetic composition of the present invention is a suspension, as a carrier component, a liquid diluent such as water, ethanol or propylene glycol, an ethoxylated isostearyl alcohol, a suspending agent such as polyoxyethylene sorbitol ester and polyoxyethylene sorbitan ester , microcrystalline cellulose, aluminum metahydroxide, bentonite, agar or tracanth, and the like can be used.
본 발명의 화장료 조성물의 제형이 파우더 또는 스프레이인 경우에는 담체 성분으로서 락토스, 탈크, 실리카, 알루미늄 히드록시드, 칼슘 실리케이트 또는 폴리아미드 파우더가 이용될 수 있고, 특히 스프레이인 경우에는 추가적으로 클로로플루오로히드로카본, 프로판/부탄 또는 디메틸 에테르와 같은 추진체를 포함할 수 있다.When the formulation of the cosmetic composition of the present invention is a powder or spray, lactose, talc, silica, aluminum hydroxide, calcium silicate or polyamide powder may be used as a carrier component, and in particular, in the case of a spray, additional chlorofluorohydro propellants such as carbon, propane/butane or dimethyl ether.
본 발명의 화장료 조성물의 제형이 계면활성제 함유 클렌징인 경우에는 담체 성분으로서 지방족 알코올 설페이트, 지방족 알코올 에테르 설페이트, 설포숙신산 모노에스테르, 이세티오네이트, 이미다졸리늄 유도체, 메틸타우레이트, 사르코시네이트, 지방산 아미드 에테르 설페이트, 알킬아미도베타인, 지방족 알코올, 지방산 글리세리드, 지방산 디에탄올아미드, 식물성 유, 라놀린 유도체 또는 에톡실화 글리세롤 지방산 에스테르 등이 이용될 수 있다.When the formulation of the cosmetic composition of the present invention is surfactant-containing cleansing, as carrier components, aliphatic alcohol sulfate, aliphatic alcohol ether sulfate, sulfosuccinic acid monoester, isethionate, imidazolinium derivative, methyl taurate, sarcosinate, Fatty acid amide ether sulfates, alkylamidobetaines, fatty alcohols, fatty acid glycerides, fatty acid diethanolamides, vegetable oils, lanolin derivatives, or ethoxylated glycerol fatty acid esters may be used.
본 발명의 화장료 조성물이 비누, 계면활성제 함유 클렌징 제형 또는 계면활성제 비함유 클렌징 제형일 경우, 피부에 도포한 후 닦아내거나 떼거나 물로 씻어낼 수도 있다. 구체적인 예로서, 상기 비누는 액상비누, 가루비누, 고형비누 및 오일비누이며, 상기 계면활성제 함유 클렌징 제형은 클렌징 폼, 클렌징 워터, 클렌징 수건 및 클렌징 팩이며, 상기 계면활성제 비 함유 클렌징 제형은 클렌징크림, 클렌징 로션, 클렌징 워터 및 클렌징 겔이며, 이에 한정되는 것은 아니다.When the cosmetic composition of the present invention is a soap, a surfactant-containing cleansing formulation, or a surfactant-free cleansing formulation, it may be applied to the skin and then wiped off, removed, or washed with water. As specific examples, the soap is liquid soap, powder soap, solid soap, and oil soap, the surfactant-containing cleansing formulation is a cleansing foam, cleansing water, cleansing towel, and a cleansing pack, and the surfactant-free cleansing formulation is a cleansing cream. , cleansing lotion, cleansing water and cleansing gel, but are not limited thereto.
이하, 본 발명의 내용을 하기 실시예 또는 실험예를 통해 더욱 상세히 설명하기로 한다. 다만, 본 발명의 권리범위가 하기 실시예 및 실험예에만 한정되는 것은 아니고, 그와 등가의 기술적 사상의 변형까지를 포함한다.Hereinafter, the contents of the present invention will be described in more detail through the following examples or experimental examples. However, the scope of the present invention is not limited only to the following examples and experimental examples, and includes modifications of equivalent technical ideas.
[[ 실시예Example 1 내지 4: 과립형 로열젤리의 제조] 1 to 4: Preparation of granular royal jelly]
하기 표 1의 조건으로 로열젤리, 덱스트린, 아카시아꿀을 혼합하여 과립형 로열젤리를 제조하였다. 덱스트린은 로열젤리 및 아카시아꿀의 효능에 방해되지 않을 최소한으로만 첨가하였다.Under the conditions shown in Table 1 below, royal jelly, dextrin, and acacia honey were mixed to prepare granular royal jelly. Dextrin was added at a minimum level that would not interfere with the efficacy of royal jelly and acacia honey.
구체적으로는 도 1에 나타낸 바와 같이, 로열젤리를 -60℃에서 36시간 동안 급속 냉동하고, 동결 건조기를 이용하여 동결한 뒤, 분쇄하여 분말을 수득하였다. 이후, 동결건조된 로열젤리 분말에 덱스트린을 첨가하여 골고루 혼합하였다. 단, 덱스트린 무첨가군은 본 과정이 생략되었다. 그 후, 로열젤리 특유의 맛을 중화하기 위하여 꿀을 첨가한 후, 손으로 분말이 뭉치도록 둥글게 저어준 뒤, 45℃에서 2시간 동안 열풍건조시켰다. 이후, 체분을 이용하여 과립을 크기별로 분리하였다.Specifically, as shown in FIG. 1, royal jelly was quickly frozen at -60 ° C. for 36 hours, frozen using a freeze dryer, and then pulverized to obtain a powder. Thereafter, dextrin was added to the lyophilized royal jelly powder and mixed evenly. However, this process was omitted for the dextrin-free group. After that, after adding honey to neutralize the unique taste of royal jelly, it was stirred roundly by hand so that the powder clumped together, and then hot air dried at 45 ° C. for 2 hours. Thereafter, the granules were separated by size using a sieve.
Acacia honey (g)
[[ 실험예Experimental example 1: 관능평가] 1: sensory evaluation]
관능검사는 본 발명의 실시예 1 내지 4의 과립형 로열젤리 각각에 대하여 과립화 정도, 맛, 향 및 색상으로 구분하여 평가하였으며, 연령과 성별을 고려하여 10대 ~ 50대 성인 남녀를 각각 연령대별로 10명씩 총 40명을 선발하여 진행하였다. 5점 채점법(관능검사 수치가 5에 가까울수록 좋음을 의미하고, 수치가 낮을수록 나쁨을 의미함)을 이용하여 평가하였다. 그 결과는 하기 표 2에 나타내었다.In the sensory test, each of the granular royal jelly of Examples 1 to 4 of the present invention was evaluated by classifying the degree of granulation, taste, flavor, and color, and considering age and gender, adult men and women in their teens and 50s were evaluated in each age group. A total of 40 people were selected, each with 10 participants. It was evaluated using a 5-point scoring method (the closer the sensory test value is to 5, the better, and the lower the value, the worse). The results are shown in Table 2 below.
표 2에 나타낸 바와 같이, 실시예 2 및 실시예 3의 조건이 로열젤리 특유의 비린맛과 향을 중화하기에 최적인 것으로 확인되었다. 다만, 실시예 3은 벌꿀의 첨가량이 높아 과립화하였을 때, 단단하게 과립화되지 않아 부서짐이 심하게 나타났다.As shown in Table 2, it was confirmed that the conditions of Examples 2 and 3 were optimal for neutralizing the fishy taste and flavor unique to royal jelly. However, in Example 3, when the granulation was performed due to the high amount of honey added, it was not granulated firmly and was severely broken.
한편, 실시예 1과 실시예 4는 과립화 정도가 섭취하기에 크게 불편함은 없었으나, 로열젤리의 함량이 높아 로열젤리 특유의 비릿한 맛과 향을 중화하기에 부족한 것으로 나타났다.On the other hand, in Examples 1 and 4, the degree of granulation was not very inconvenient for ingestion, but the content of royal jelly was high, so it was found that it was insufficient to neutralize the fishy taste and aroma unique to royal jelly.
따라서, 과립화 정도, 맛, 향 및 색상을 전반적으로 평가한 결과, 실시예 2의 과립형 로열젤리의 관능상 평가가 가장 우수하게 나타났다.Therefore, as a result of overall evaluation of the degree of granulation, taste, flavor and color, the sensory evaluation of the granular royal jelly of Example 2 was the best.
[[ 실험예Experimental example 2: 2: 피부세포skin cells 증식 및 이주 효능 평가] Evaluation of proliferation and migration efficacy]
1. 세포 배양 1. Cell culture
본 실험에 사용된 HaCaT (human keratinocyte cell line) 세포는 한국세포주은행(한국)으로 구입하여 사용하였다. HaCaT 세포는 DMEM (dulbecco’s modified eagle medium; Thermo Fisher Scientific, USA) 배지에 10% FBS (fetal bovine serum; Thermo Fisher Scientific, USA)와 1% penicillin/strptomycine (penicillin 100IU/㎖, streptomycin 100㎍/㎖; Thermo Fisher Scientific, USA)를 첨가하여 37℃, 5% CO2 조건의 배양기에서 배양하였다.HaCaT (human keratinocyte cell line) cells used in this experiment were purchased from Korea Cell Line Bank (Korea). HaCaT cells were cultured in DMEM (dulbecco's modified eagle medium; Thermo Fisher Scientific, USA) medium containing 10% FBS (fetal bovine serum; Thermo Fisher Scientific, USA) and 1% penicillin/strptomycine (
2. 세포 증식효능 평가2. Evaluation of cell proliferation efficacy
HaCaT 세포 증식효능은 EZ-Cytox cell viability assay kit(Dogen, Korea)를 사용하여 측정하였다. HaCaT 세포를 96웰 플레이트에 최종 농도가 2×105cells/㎖가 되도록 분주한 뒤 37℃, 5% CO2 인큐베이터(incubator)에서 24시간 동안 배양하였다.HaCaT cell proliferation efficacy was measured using the EZ-Cytox cell viability assay kit (Dogen, Korea). HaCaT cells were dispensed to a final concentration of 2×10 5 cells/ml in a 96-well plate, and cultured for 24 hours in a 37° C., 5% CO 2 incubator.
배양된 세포에 실시예 1 내지 4의 과립형 로열젤리 각각을 10㎍/㎖씩 처리하였다. 이후, EZ-Cytox 시약 10㎕를 처리한 다음 4시간 동안 배양 후 microplate reader(Molecular Devices, Canada)를 이용하여 480㎚에서 흡광도를 측정하였다. 세포 증식 효능은 대조군에 대한 생존율로 나타내었다.The cultured cells were treated with 10 μg/ml of each of the granular royal jelly of Examples 1 to 4. Thereafter, 10 μl of EZ-Cytox reagent was treated, followed by incubation for 4 hours, and absorbance was measured at 480 nm using a microplate reader (Molecular Devices, Canada). Cell proliferation efficacy was expressed as survival rate relative to the control group.
도 2에 나타난 바와 같이, 실시예 2의 과립형 로열젤리의 세포 증식 효과가 가장 우수한 것으로 확인되었다. 실시예 2의 과립형 로열젤리는 로열젤리 및 벌꿀의 효능의 상쇄없이, 시너지 효과를 발휘한 것으로 판단된다.As shown in Figure 2, it was confirmed that the cell proliferation effect of the granular royal jelly of Example 2 was the best. It is judged that the granular royal jelly of Example 2 exerted a synergistic effect without offsetting the efficacy of royal jelly and honey.
3. 피부 세포 이주효능 평가3. Evaluation of skin cell migration efficacy
피부 세포 이주효능을 평가하기 위하여, 6웰 플레이트에 HaCaT 세포를 2×105cells/㎖로 분주 한 다음 24시간 동안 배양하여 세포를 안정화하였다. 충분히 세포가 증식한 다음 멸균한 200㎕ 파이펫팁으로 배양 접시를 긁어 세포의 상처를 발생시킨 뒤 배양된 세포에 실시예 1 내지 4의 과립형 로열젤리 각각을 10㎍/㎖씩 처리한 후, 시간대별로 세포의 이동 정도를 현미경으로 관찰하였다.In order to evaluate the skin cell migration efficacy, HaCaT cells were dispensed in a 6-well plate at 2×10 5 cells/ml and cultured for 24 hours to stabilize the cells. After sufficient cell proliferation, the culture dish was scratched with a sterilized 200 μl pipette tip to injure the cells, and then the cultured cells were treated with 10 μg/ml of each of the granular royal jelly of Examples 1 to 4, and then The degree of migration of each cell was observed under a microscope.
도 3에 나타난 바와 같이, 실시예 2의 과립형 로열젤리의 세포 이주 효과가 가장 우수한 것으로 확인되었다. 실시예 2의 과립형 로열젤리는 로열젤리 및 벌꿀의 효능의 상쇄없이, 시너지 효과를 발휘한 것으로 판단된다.As shown in Figure 3, it was confirmed that the cell migration effect of the granular royal jelly of Example 2 was the best. It is judged that the granular royal jelly of Example 2 exerted a synergistic effect without offsetting the efficacy of royal jelly and honey.
[[ 실험예Experimental example 3: 헬리코박터 억제 효능 평가] 3: Helicobacter pylori inhibitory efficacy evaluation]
본 실험에 사용한 헬리코박터 파이로리(Helicobacter pylori;H . pylori, ATCC 43526)균주는 한국미생물 보존센터(대전, 한국)로부터 구입하여 10% sheep blood(MB cell, CA, USA)가 포함된 BHI(brain heart infusion, BD, NY, USA) 배지에 접종 후, 10% CO2가 유지되는 배양기에서 37℃로 배양하여 실험에 사용하였다. Helicobacter pylori used in this experiment pylori; H. pylori, ATCC 43526) strain was purchased from the Korea Microbial Conservation Center (Daejeon, Korea) and inoculated into BHI (brain heart infusion, BD, NY, USA) medium containing 10% sheep blood (MB cell, CA, USA). , 10% CO 2 It was used in the experiment by culturing at 37 ℃ in an incubator maintained.
헬리코박터 파이로리에 대한 본 발명의 항균활성은 평판배지확산법을 이용하여 측정하였다. 이를 위하여, 헬리코박터 파이로리를 평판배지에 도말 접종한 다음 독이 집적된 직경 8㎜의 페이퍼 디스크(paper disk, Advantec, Japan)를 실시예 1 내지 4의 과립형 로열젤리 각각을 10㎍/㎖씩 평판배지에 올린 후, 48시간 동안 배양하면서 생성된 투명한 지지환의 크기를 측정하여, 표 3 및 도 4에 나타내었다.The antibacterial activity of the present invention against Helicobacter pylori was measured using a plate medium diffusion method. To this end, Helicobacter pylori was smeared and inoculated on a plate medium, and then a paper disk (Advantec, Japan) having a diameter of 8 mm in which the poison was accumulated was added to each of the granular royal jelly of Examples 1 to 4 at 10 μg/ml each. After uploading, by measuring the size of the transparent support ring produced while culturing for 48 hours, it is shown in Table 3 and Figure 4.
표 3 및 도 4에 나타낸 바와 같이, 실시예 2의 과립형 로열젤리의 헬리코박터균 억제 효과가 가장 우수한 것으로 확인되었다. 실시예 2의 과립형 로열젤리는 로열젤리 및 벌꿀의 효능의 상쇄없이, 시너지 효과를 발휘한 것으로 판단된다.As shown in Table 3 and FIG. 4, it was confirmed that the granular royal jelly of Example 2 had the best inhibitory effect against Helicobacter pylori. It is judged that the granular royal jelly of Example 2 exerted a synergistic effect without offsetting the efficacy of royal jelly and honey.
Claims (14)
(b) 상기 단계 (a)에서 동결건조된 로열젤리에 아카시아꿀 및 덱스트린을 혼합하는 단계; 및
(c) 상기 단계 (b)의 혼합물을 열풍건조하는 단계; 를 포함하는 헬리코박터균 억제 및 피부 재생용 과립형 로열젤리의 제조방법으로서,
상기 혼합물은 동결건조 로열젤리, 덱스트린, 아카시아꿀이 5 : 1 : 5의 중량비율로 혼합되어 이루어진 것을 특징으로 하는 제조방법.
(a) freeze-drying royal jelly;
(b) mixing acacia honey and dextrin with the royal jelly freeze-dried in step (a); and
(c) drying the mixture of step (b) with hot air; A method for producing granular royal jelly for inhibiting Helicobacter pylori and regenerating skin, comprising:
The mixture is a manufacturing method characterized in that the freeze-dried royal jelly, dextrin, acacia honey is mixed in a weight ratio of 5: 1: 5.
상기 단계 (a)의 동결건조는,
-80 ~ -10℃에서 12~72시간 동안 수행되는 것을 특징으로 하는 헬리코박터균 억제 및 피부 재생용 과립형 로열젤리의 제조방법.
According to claim 1,
The lyophilization of step (a) is,
A method for producing granular royal jelly for inhibiting Helicobacter pylori and regenerating skin, characterized in that it is performed at -80 to -10 ° C for 12 to 72 hours.
상기 단계 (c)의 열풍건조는,
30~50℃에서 1~4시간 동안 수행되는 것을 특징으로 하는 헬리코박터균 억제 및 피부 재생용 과립형 로열젤리의 제조방법.
According to claim 1,
The hot air drying in step (c),
Method for producing granular royal jelly for inhibiting Helicobacter pylori and regenerating skin, characterized in that it is carried out at 30 ~ 50 ℃ for 1 to 4 hours.
Granular royal jelly for inhibiting Helicobacter pylori and regenerating skin prepared by the method of claim 1.
A food composition comprising the royal jelly of claim 8.
A health supplement comprising the royal jelly of claim 8.
A cosmetic composition comprising the royal jelly of claim 8.
상기 화장료 조성물은,
피부재생용인 것을 특징으로 하는 화장료 조성물.According to claim 13,
The cosmetic composition,
Cosmetic composition characterized in that for skin regeneration.
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