KR102476660B1 - Cosmetic composition for skin improvement containing vitamin and natural extracts - Google Patents
Cosmetic composition for skin improvement containing vitamin and natural extracts Download PDFInfo
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- KR102476660B1 KR102476660B1 KR1020220115066A KR20220115066A KR102476660B1 KR 102476660 B1 KR102476660 B1 KR 102476660B1 KR 1020220115066 A KR1020220115066 A KR 1020220115066A KR 20220115066 A KR20220115066 A KR 20220115066A KR 102476660 B1 KR102476660 B1 KR 102476660B1
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- skin
- extract
- cosmetic composition
- improvement
- vitamin
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Abstract
Description
본 발명은 비타민 혼합물, 산자나무열매 추출물, 아스타잔틴 및 천연 복합 추출물을 포함하는 피부 개선용 화장료 조성물에 관한 것으로, 피부 노화 방지 및 주름 개선 효능을 가지고 있으며, 피부 미백 및 수분 보습 효능이 우수한 피부 개선용 화장료 조성물 및 이의 제조방법에 관한 것이다. The present invention relates to a cosmetic composition for skin improvement comprising a vitamin mixture, sea buckthorn fruit extract, astaxanthin and a natural complex extract, which has anti-aging and anti-wrinkle effects, and has excellent skin whitening and moisturizing effects. It relates to a cosmetic composition for improvement and a manufacturing method thereof.
의술의 발달로 평균수명이 연장됨에 따라 가능한 젊음을 길게 유지하고자 하는 욕구는 남녀노소의 공통 관심사가 되었으며, 가장 쉽게 드러나는 피부를 밝고 탄력있게 유지하기 위한 열망이 높아지고 있다. 이러한 피부에 대한 관심사 중 피부 노화는 노화가 발생하는 원인과 위치에 따라 크게 네가지로 구분된다.As the average lifespan has been extended due to the development of medical technology, the desire to maintain youth as long as possible has become a common concern for men and women of all ages, and the desire to keep the skin, which is most easily revealed, bright and elastic is increasing. Among these skin concerns, skin aging is largely divided into four categories according to the cause and location of aging.
첫 번째는 표피에서의 노화 현상을 들 수 있다. 인간은 나이가 들면서 세포 생산이 둔화되는데, 피부 재생이 둔화될수록 피부 안색이 활기가 없어 보이고 메말라 보일 수 있다. 노화가 진행됨에 따라 피부의 최외각층인 표피의 각질 형성 세포에서 케라틴 합성이 감소되며, 각질층의 케라틴층과 자연 보습 인자들인 필라그린, 케라토피알린 입자 그리고 여러 효소가 감소되고, 각종 효소들의 결핍으로 인해 탈수 현상이 심해지며, 죽은 각질 세포들은 제대로 떨어져 나가지 못하고 정체된다. 또한 각질층의 수분 결핍 현상이 심화되며 세포외 기질의 감소로 인해 기저층에서 각질층까지의 수분의 이동 현상이 둔화된다. 그리고 피지 생산의 감소로 산성보호막 또한 부실해진다. 기저층에 있는 멜라닌 세포는 약 10년마다 10 내지 20% 정도씩 감소하는데, 노화된 피부가 멜라닌 색소를 생산할 때는 색소의 성숙과 분산이 고르게 되지 않아 피부톤이 불규칙해 보이고, 전체적으로 얼룩덜룩해 보일 수 있다.The first is the aging phenomenon in the epidermis. As humans age, cell production slows down, and as skin regeneration slows down, the skin complexion can look dull and dry. As aging progresses, keratin synthesis is reduced in the keratinocytes of the epidermis, the outermost layer of the skin, and the keratin layer of the stratum corneum, filaggrin, keratophyalin particles, and various enzymes, which are natural moisturizing factors, are reduced, and various enzymes are deficient. As a result, dehydration becomes severe, and dead keratinocytes do not fall off properly and become stagnant. In addition, water deficiency in the stratum corneum is intensified, and the movement of water from the basal layer to the stratum corneum is slowed due to the reduction of the extracellular matrix. And the decrease in sebum production also weakens the acidic protective film. Melanocytes in the basal layer decrease by 10 to 20% about every 10 years. When aging skin produces melanin pigment, the maturation and dispersion of pigment is not even, so the skin tone looks irregular and overall may look mottled.
두 번째는, 진피에서의 노화 현상이다. 노화가 진행됨에 따라, 피부의 구조를 지탱하는 기본 버팀목의 역할을 하는 섬유 조직으로 된 콜라겐과 탄력 섬유가 경화되고 불용성이 되고, 이에 따라 콜라겐 단백질 분자와 피부에 탄성을 주는 탄력 섬유가 가교화 과정을 겪게 된다. 세포 사이 사이와 탄력 섬유 등의 섬유질 사이를 채우고 있는 물질들을 기질(ground substance)이라고 하며, 대표적인 것으로는 히알루론산(hyaluronic acid) 또는 무코다당류(mucopolysaccharides)가 있다. 상기 기질은 단백질과 탄수화물 성분들이 복합되어 있어 당단백질(glycosaminoglycans, GAG)이라 불리우며, 수준을 보유하는 능력이 강력하다. 그러나 노화가 진행될수록 히알루로니데이즈(hyaluronidase)라는 히알루론산 분해 효소가 증가하여 진피에서의 히알루론산의 양은 점차 감소하게 되며, 이에 따라 피부의 주름이 생기고 탄력이 떨어지는 현상이 발생하게 된다.The second is the aging phenomenon in the dermis. As aging progresses, collagen and elastic fibers made of fibrous tissue, which serve as the basic support for supporting the skin structure, harden and become insoluble, and accordingly, collagen protein molecules and elastic fibers that give elasticity to the skin undergo a crosslinking process. will experience Substances filling between cells and between fibers such as elastic fibers are called ground substances, and representative examples include hyaluronic acid and mucopolysaccharides. The matrix is called glycosaminoglycans (GAG) because it is a combination of protein and carbohydrate components, and has a strong ability to retain levels. However, as aging progresses, hyaluronic acid degrading enzyme called hyaluronidase increases and the amount of hyaluronic acid in the dermis gradually decreases, resulting in wrinkles and loss of elasticity of the skin.
세 번째는 피부 세포의 손상을 유발하는 활성산소를 들 수 있다. 활성산소는 지나치게 많아질 경우 체내의 항산화 방어계를 무너뜨려 단백질, 지질, DNA와 같은 세포 성분을 손상시키고, 이에 따라 세포 기능이 변질되며 궁극적으로 피부 노화가 촉진될 수 있다. 또한, 활성산소는 교원질 대사에 작용하여 직접적으로 교원질을 파괴시킬 뿐 아니라, 콜라겐의 결핍을 초래함으로써 결합조직을 손상시킨다. 뿐만 아니라, 활성산소는 세포들 사이의 공간에서 많은 양의 물을 함유하는 능력을 가지고 있어 피부의 탄력성을 유지하며 충격을 흡수하는 역할을 하는 히알루론산 사슬도 절단하여, 피부 탄력 및 피부 수분을 감소시키고, 이에 따라 피부 노화를 가속화시키게 한다. 이러한 활성산소는 흡연, 스트레스, 과도한 운동, 피부병, 바이러스 감염 및 자외선 등 건강을 위협하는 여러가지 인자들뿐만 아니라, 생명을 유지하는데 필수적인 호흡과 소화의 과정 중에서도 발생한다.The third is active oxygen that causes damage to skin cells. When active oxygen is excessive, it breaks down the body's antioxidant defense system and damages cellular components such as proteins, lipids, and DNA, thereby altering cellular functions and ultimately accelerating skin aging. In addition, active oxygen not only directly destroys collagen by acting on collagen metabolism, but also damages connective tissue by causing collagen deficiency. In addition, active oxygen has the ability to contain a large amount of water in the space between cells, maintaining skin elasticity and cutting the hyaluronic acid chain, which plays a role in absorbing shock, reducing skin elasticity and skin moisture. and thereby accelerate skin aging. Such active oxygen is generated not only from various health-threatening factors such as smoking, stress, excessive exercise, skin disease, viral infection, and ultraviolet rays, but also during the process of breathing and digestion, which are essential for maintaining life.
따라서 인간은 지속적으로 활성산소의 위협에 노출되어 있으므로, 이에 따라 다양한 항산화 성분을 이용하여 피부 노화로 인한 상기 피부 손상들을 방지하기 위한 새로운 화장료 조성물에 대한 개발이 요구된다.Therefore, since humans are continuously exposed to the threat of active oxygen, development of a new cosmetic composition for preventing the skin damage due to skin aging using various antioxidant components is required.
본 발명의 목적은 산자나무열매 추출물, 비타민 혼합물, 아스타잔틴 및 천연 복합 추출물을 포함하는 피부 개선용 화장료 조성물을 제공하는 것이다. An object of the present invention is to provide a cosmetic composition for skin improvement comprising a sea buckthorn fruit extract, a vitamin mixture, astaxanthin and a natural complex extract.
상기와 같은 목적을 달성하기 위한 본 발명의 일 측면은 산자나무열매 추출물, 비타민 혼합물, 아스타잔틴 및 천연 복합 추출물을 포함하는 피부 개선용 화장료 조성물로서, 상기 비타민 혼합물은 소듐아스코빌포스페이트(Sodium Ascorbyl Phosphate), 나이아신아마이드(Niacinamide), 판테놀(Panthenol), 바이오틴(Biotin), 티아민(Thiamine), 피리독신(Pyridoxine), 토코페릴아세테이트(Tocopheryl Acetate), 레티닐팔미테이트(Retinyl Palmitate), 폴릭애씨드(Folic Acid), 사이아노코발아민(Cyanocobalamin) 및 이의 유도체로 이루어진 군에서 선택된 어느 하나 이상을 포함하고, 상기 천연 복합 추출물은 사과 추출물 및 자초 추출물을 포함하는, 피부 개선용 화장료 조성물 피부 개선용 화장료 조성물에 관한 것이다.One aspect of the present invention for achieving the above object is a cosmetic composition for skin improvement comprising a sea buckthorn fruit extract, a vitamin mixture, astaxanthin and a natural complex extract, wherein the vitamin mixture is sodium ascorbyl phosphate (Sodium Ascorbyl Phosphate), Niacinamide, Panthenol, Biotin, Thiamine, Pyridoxine, Tocopheryl Acetate, Retinyl Palmitate, Folic Acid Acid), cyanocobalamin (Cyanocobalamin), and at least one selected from the group consisting of derivatives thereof, wherein the natural complex extract includes an apple extract and a self-injection extract, a cosmetic composition for skin improvement, a cosmetic composition for skin improvement it's about
본 발명에서 산자나무열매(Hippophae rhamnoides L)는 보리수과에 속하는 관목으로서 100여종 이상의 성분을 포함하고 있으며, 특히 비타민(A, B, C, E, F, K) 등 유효한 성분을 많이 함유하고 있다. 항산화 물질인 카로티노이드의 베타카로틴, 플라보노이드 성분이 풍부하게 들어있어 강력한 항산화 작용을 하는 것으로 알려져 있다. In the present invention, the sea buckthorn fruit ( Hippophae rhamnoides L ) is a shrub belonging to the Limeaceae family and contains more than 100 kinds of ingredients, especially vitamins (A, B, C, E, F, K) and other effective ingredients. Beta-carotene of carotenoids, which are antioxidants, and flavonoids are rich in antioxidants, so it is known to have a strong antioxidant effect.
본 발명에서 비타민 혼합물은 비타민A, 비타민B, 비타민C, 비타민E 또는 이의 유도체를 포함하는 것일 수 있다. 일반적으로 비타민A는 레티노산, 레티놀, 레티놀 프로피오네이트 형태로 사용되며, 레티노산은 항균작용으로 여드름 완화 효능이 있으며, 피부의 유분기를 감소시키는 효과를 가진다. 또한 피부 내 엘라스틴 섬유와 히알루론산을 증가시키고, 색소 침착 완화에 효능이 있는 것으로 알려져 있다. In the present invention, the vitamin mixture may include vitamin A, vitamin B, vitamin C, vitamin E or a derivative thereof. In general, vitamin A is used in the form of retinoic acid, retinol, and retinol propionate, and retinoic acid has an antibacterial effect to relieve acne and has an effect of reducing oiliness of the skin. It is also known to increase elastin fibers and hyaluronic acid in the skin and to be effective in mitigating pigmentation.
비타민B는 피부의 신진대사를 활발하게 하여 세포의 재생을 도와주는 물질이다. 또한 비타민C는 수용성 항산화제로 콜라겐과 엘라스틴을 활발하게 하며, 햇빛으로 인한 화상 및 주름 생성을 완화하고, 자외선 노출 후 생기는 활성산소와 염증을 줄이는 등의 효과가 있다. 특히 강력한 항산화 성분으로 피부 색소침착, 미백 및 활성 산소 제거에 따른 노화 방지 용도로 활용되고 있다.Vitamin B is a substance that activates the metabolism of the skin and helps cell regeneration. In addition, vitamin C is a water-soluble antioxidant that activates collagen and elastin, relieves burns and wrinkles caused by sunlight, and reduces active oxygen and inflammation after exposure to ultraviolet rays. In particular, as a powerful antioxidant, it is used for anti-aging purposes due to skin pigmentation, whitening, and removal of active oxygen.
비타민E는 지용성 항산화제로 피지와 피부의 가장 바깥에 있는 죽은 표면세포까지 도달할 수 있다. 피부 효능을 위해 토코페롤 아세테이트, 알파 토코페롤 형태로 사용된다. 비타민 C는 수용성으로 피부 수용성 부분의 활성산소를 제거하며, 비타민 E는 같은 방법으로 지용성 부분에 작용하여 함께 사용시 피부 개선에 효과적으로 알려져 있다. Vitamin E is a fat-soluble antioxidant that can reach sebum and the outermost dead surface cells of the skin. It is used in the form of tocopherol acetate, alpha tocopherol, for skin benefits. Vitamin C is water-soluble and removes active oxygen in the water-soluble part of the skin, and vitamin E acts on the fat-soluble part in the same way and is known to improve skin effectively when used together.
본 발명에서, 상기 비타민 혼합물은 소듐아스코빌포스페이트(Sodium Ascorbyl Phosphate), 나이아신아마이드(Niacinamide), 판테놀(Panthenol), 바이오틴(Biotin), 티아민(Thiamine), 피리독신(Pyridoxine), 토코페릴아세테이트(Tocopheryl Acetate), 레티닐팔미테이트(Retinyl Palmitate), 폴릭애씨드(Folic Acid) 및 사이아노코발아민(Cyanocobalamin)으로 이루어진 군에서 선택된 어느 하나 이상일 수 있다. In the present invention, the vitamin mixture is Sodium Ascorbyl Phosphate, Niacinamide, Panthenol, Biotin, Thiamine, Pyridoxine, Tocopheryl Acetate ), Retinyl Palmitate, Folic Acid, and Cyanocobalamin.
상기 소듐아스코빌포스페이트(Sodium Ascorbyl Phosphate)는 비타민C인 아스코빅 애씨드의 수용성 유도체로서, 피부의 지질 장벽의 통과율을 높임으로써 안정적으로 피부에 전달될 수 있고 생체이용률이 높은 특징을 가진다. The sodium ascorbyl phosphate (Sodium Ascorbyl Phosphate) is a water-soluble derivative of ascorbic acid, which is vitamin C, and can be stably delivered to the skin by increasing the pass rate of the lipid barrier of the skin and has high bioavailability.
상기 나이아신아마이드(Niacinamide)는 수용성 비타민B3 또는 나이아신의 수용성 유도체로서, 멜라닌세포에서 각질세포로 멜라노좀의 이동을 억제하여 피부에 미백효과를 가지는 것으로 알려져 있다. Niacinamide is a water-soluble derivative of vitamin B3 or niacin, and is known to have a whitening effect on the skin by inhibiting the movement of melanosomes from melanocytes to keratinocytes.
상기 판테놀(Panthenol)은 비타민B5 또는 판토테닉애씨드의 알코올 유사체로서, 피부에 흡수 시 판토테닉애씨드의 형태로 바뀌어 수분을 결합시킴으로써 피부 표면에 윤활제로 작용한다. 피부 보습 및 피부결 개선외에도 모발 윤기 표현에 효과적이어서, 피부 및 모발 손상 예방 및 방지 용도로 활용되고 있다. The panthenol is an alcohol analog of vitamin B5 or pantothenic acid, and when absorbed into the skin, it is changed to the form of pantothenic acid and binds moisture to act as a lubricant on the skin surface. In addition to moisturizing the skin and improving skin texture, it is effective in expressing hair gloss, so it is used for preventing and preventing skin and hair damage.
상기 바이오틴(Biotin)은 비타민B7 성분으로서 손톱, 피부를 구성하는 물질 중 하나이다. 케라틴의 합성을 도와 모발의 성장 및 조직 강화에 기여하며, 피부 수분 유지 효과를 가지는 비타민 성분으로 알려져 있다. The biotin (Biotin) is one of the substances constituting the nails and skin as a vitamin B7 component. It is known as a vitamin ingredient that helps the synthesis of keratin, contributes to hair growth and tissue strengthening, and has the effect of maintaining skin moisture.
상기 피리독신(Pyridoxine)은 비타민B6로서, 피부의 저항력을 높여주고 피지조절능력이 있어 여드름 개선에 효과적으로 알려져 있다. 피리독신은 단백질 대사의 조효소로 작용하기 때문에 피부의 수분을 유지하는데 도움을 줄 수 있다. The pyridoxine (Pyridoxine) is vitamin B6, it is known to be effective in improving acne because it increases skin resistance and has the ability to control sebum. Since pyridoxine acts as a coenzyme for protein metabolism, it can help maintain moisture in the skin.
상기 토코페릴아세테이트(Tocopheryl Acetate)는 비타민E 유도체로서 토코페롤 및 아세틱애씨드를 아세틸화시켜 얻은 지용성 물질이다. 토코페릴아세테이트는 세포막을 구성하는 불포화지방산의 산화를 억제시키는 항산화 성분으로서, 피부 손상을 지연 또는 예방할 수 있어 자외선 노출에 따른 홍반, 주름, 부종 등의 예방을 위한 용도로 활용되고 있다. The tocopheryl acetate (Tocopheryl Acetate) is a vitamin E derivative and is a fat-soluble substance obtained by acetylating tocopherol and acetic acid. Tocopheryl acetate is an antioxidant component that inhibits the oxidation of unsaturated fatty acids constituting cell membranes, and can delay or prevent skin damage, so it is used for preventing erythema, wrinkles, edema, etc. caused by exposure to ultraviolet rays.
상기 레티닐팔미테이트(Retinyl Palmitate)는 비타민A 또는 레티놀의 유도체로서 안정성을 높인 물질이다. 레티닐팔미테이트는 세포의 재생을 활성화시켜 표피의 각질 형성을 개선하고, 콜라겐과 엘라스틴 합성을 촉진하여 주름개선 효과가 탁월한 것으로 알려져 있다. 또한 기미 제거에 효과적으로 알려져 있다. The retinyl palmitate (Retinyl Palmitate) is a substance with increased stability as a derivative of vitamin A or retinol. Retinyl palmitate is known to have an excellent anti-wrinkle effect by activating cell regeneration to improve epidermal keratin formation and promoting collagen and elastin synthesis. It is also known to be effective in removing melasma.
상기 폴릭애씨드(Folic Acid)는 비타민B9 성분으로, 폴산, 엽산으로 알려져 있다. 피부의 세포 형성에 영향을 주며, 재생을 활성화시켜 기미, 주름 예방에 효과적이며, 여드름 및 탈모 발생을 줄이는데도 도움을 주는 것으로 알려져 있다. The polyacid is a vitamin B9 component, and is known as folic acid or folic acid. It affects the formation of skin cells, activates regeneration, is effective in preventing melasma and wrinkles, and is known to help reduce acne and hair loss.
상기 사이아노코발아민(Cyanocobalamin)은 비타민12로서, 폴릭애씨드 성분과 함께 작용하여 노화 방지, 아토피를 포함한 피부 염증 개선 등의 효과가 있는 것으로 알려져 있다.Cyanocobalamin is vitamin 12, and is known to have effects such as anti-aging and improvement of skin inflammation including atopy by acting together with a polyacid component.
상기 아스타잔틴은 강력한 항산화제로서 자외선에 의한 피부손상에 효과적으로 알려져 있으며, 피부세포 사멸 및 활성산소 발생을 감소시키는 것으로 알려져 있다. 특히 항산화 작용이 우수한 만큼 피부세포의 생리 활성능력 개선을 통한 피부재생, 주름개선 등의 작용을 기대할 수 있다. The astaxanthin is known to be effective against skin damage caused by ultraviolet rays as a strong antioxidant, and is known to reduce skin cell death and generation of active oxygen. In particular, as it has excellent antioxidant activity, it can be expected to have effects such as skin regeneration and wrinkle improvement through improvement of the physiological activity of skin cells.
본 발명에서 상기 천연 복합 추출물은 사과 추출물, 자초 추출물 및/또는 폴스아르니카 꽃 추출물을 포함하는 것일 수 있다. In the present invention, the natural complex extract may include an apple extract, a self-injection extract, and/or a Falls Arnica flower extract.
상기 사과 추출물은 사과산, 비타민, 당분이 피부에 유용한 성분으로 활력에 영향을 주며, 사과 내 폴리페놀 성분의 항산화 작용으로 피부 노화 예방 및 원기회복 등에 효과가 있다고 알려져 있다. 상기 사과 추출물의 추출 방법은 제한되지 않고 당해 기술의 통상적인 추출 방법을 사용할 수 있으나, 바람직하게는 초고압 저온 상태의 추출 방법을 이용하여 추출 효율을 높일 수 있다. 상기 추출 방법은 한국등록특허 제10-1239361호를 참고할 수 있다. The apple extract is known to have malic acid, vitamins, and sugars as components useful for the skin, which affect vitality, and are effective in preventing skin aging and restoring energy due to the antioxidant action of polyphenol components in apples. The extraction method of the apple extract is not limited and a conventional extraction method of the art may be used, but preferably an ultra-high pressure and low temperature extraction method may be used to increase the extraction efficiency. For the extraction method, reference may be made to Korean Patent Registration No. 10-1239361.
상기 자초는 지치(Lithospermum erythrorhizon)의 뿌리로서, 시코닌, 아세틸시코닌 등과 함께 다당류인 리소스퍼먼 등의 성분을 함유하며, 혈액 순환 촉진 작용, 해독작용, 항균 및 항염작용 등이 있어 화상, 습진 등을 치료하는데 사용되는 약물 중 하나이다. 아토피를 포함한 피부 염증, 홍반 등의 완화를 위한 용도로도 사용되고 있다. The self-inflicting is the root of Lithospermum erythrorhizon , and contains components such as shikonin, acetylshikonine, etc., which are polysaccharides, such as resource perman, and has blood circulation promoting action, detoxification action, antibacterial and anti-inflammatory action, so that burns, eczema, etc. It is one of the drugs used to treat It is also used for relieving skin inflammation and erythema, including atopy.
상기 폴스아르니카 꽃은 유럽원산의 다년초로서 높이 50cm 내외의 황색의 꽃이다. 폴스아르니카는 신경계, 소화기관, 호흡기관, 순환기간 등에 작용하고, 이뇨작용, 정화작용, 해열작용 등이 있는 것으로 알려져 있다. 또한 피부 윤기 및 활기 부여에 효과가 있는 것으로 알려지면서 피부 보습 등에도 일부 사용되고 있다. The Falls Arnica flower is a yellow flower of about 50 cm in height as a perennial plant native to Europe. Falls Arnica acts on the nervous system, digestive system, respiratory system, and circulatory system, and is known to have diuretic, purifying, and antipyretic effects. In addition, as it is known to be effective in giving skin luster and vitality, it is also partially used for moisturizing the skin.
본 발명의 자초, 폴스아르니카 꽃을 추출하는 방법은 특별히 제한되지 아니하며, 당해 기술 분야에서 통상적으로 사용하는 방법에 따라 추출할 수 있다. 상기 추출 방법의 비제한적인 예로는, 열수 추출법, 초음파 추출법, 여과법, 환류 추출법 등을 들 수 있으며, 이들은 단독으로 수행되거나 2 종 이상의 방법을 병용하여 수행될 수 있다. The method of extracting the self-inflicted, Falls arnica flower of the present invention is not particularly limited, and can be extracted according to a method commonly used in the art. Non-limiting examples of the extraction method include a hot water extraction method, an ultrasonic extraction method, a filtration method, a reflux extraction method, and the like, which may be performed alone or in combination of two or more methods.
본 발명에서 사용되는 추출용매의 종류는 특별히 제한되지 아니하며, 당해 기술 분야에서 공지된 임의의 용매를 사용할 수 있다. 상기 추출 용매의 비제한적인 예로는 물(정제수), C1 내지 C4의 무수 또는 저급 알코올, 상기 물과 저급 알코올의 혼합 용매, 아세톤, 1,3-부틸렌글리콜, 에틸아세테이트, 클로로포름으로 이루어진 군에서 선택되는 1 종 이상으로, 단독으로 2종 이상 혼합하여 사용할 수 있다. The type of extraction solvent used in the present invention is not particularly limited, and any solvent known in the art may be used. Non-limiting examples of the extraction solvent include water (purified water), C 1 to C 4 anhydrous or lower alcohol, a mixed solvent of the water and lower alcohol, acetone, 1,3-butylene glycol, ethyl acetate, chloroform It is 1 or more types selected from the group, and it can use individually and in mixture of 2 or more types.
상기 원료에 포함된 유효성분은 용매의 극성에 따라 추출 비율이 상이해질 수 있다. 특히, 상기 용매는 상기 원료의 생리 활성 물질의 추출에 있어서 선택성이 뛰어난 알코올이 바람직할 수 있고, 바람직하게는 에탄올 추출에 의해 최적의 피부 개선 효과가 구현될 수 있다.The active ingredient included in the raw material may have a different extraction ratio depending on the polarity of the solvent. In particular, the solvent may preferably be an alcohol with excellent selectivity in the extraction of the physiologically active substance of the raw material, and preferably, an optimal skin improvement effect may be realized by ethanol extraction.
특히 물과 에탄올은 극성이 상이하여, 각 극성에 따라 추출되는 유효성분이 차이가 날 수 있으므로 최적의 피부 개선 효과가 구현될 수 있도록 상기 에탄올의 농도를 적절히 제어할 수 있다. 다만, 상기 에탄올은 농도가 50% 미만이면 피부 개선 효과를 나타내는 유효 성분이 충분하게 추출되지 않을 수 있고, 농도가 80% 초과이면 적정한 수율이 구현되지 않을 수 있으므로, 상기 에탄올의 농도를 상기 범위 내에서 적절히 조정할 수 있다. In particular, since water and ethanol have different polarities, the active ingredient extracted according to each polarity may differ, so that the concentration of ethanol can be appropriately controlled so that the optimal skin improvement effect can be realized. However, if the concentration of ethanol is less than 50%, the active ingredient exhibiting the skin improvement effect may not be sufficiently extracted, and if the concentration is more than 80%, an appropriate yield may not be realized. can be adjusted appropriately.
상기 화장료 조성물은 100 중량부에 대하여, 산자나무열매 추출물 0.05 내지 0.2 중량부, 천연 복합 추출물 0.1 내지 0. 5 중량부 및 비타민 혼합물 1.5 내지 3 중량부를 포함할 수 있다. The cosmetic composition may include 0.05 to 0.2 parts by weight of sea buckthorn fruit extract, 0.1 to 0.5 parts by weight of a natural complex extract, and 1.5 to 3 parts by weight of a vitamin mixture, based on 100 parts by weight.
구체적으로, 상기 천연 복합 추출물은 사과 추출물 및 자초 추출물이 1 : 0.5 내지 1 : 1의 비율로 혼합될 수 있다. 또한 사과 추출물, 자초 추출물 및 폴스아르니카 꽃 추출물 또한 1 : 0.5 : 0.5 내지 1 : 1 : 1의 비율로 혼합될 수 있다. Specifically, in the natural complex extract, apple extract and self-injection extract may be mixed in a ratio of 1: 0.5 to 1: 1. In addition, apple extract, self-injection extract, and false arnica flower extract may also be mixed in a ratio of 1: 0.5: 0.5 to 1: 1: 1.
상기 산자나무열매 추출물이 0.05 및 천연 복합 추출물 0.1 미만으로 함유될 경우 피부 상태의 개선 효과가 충분히 발휘되지 않을 수 있다. 한편 산자나무열매 추출물이 0.2 중량부를 초과하거나, 천연 복합 추출물이 0.5 중량부를 초과할 경우 피부에 자극을 유발할 수 있으며, 피부 안전성이 감소할 수 있다. When the content of the sea buckthorn fruit extract is less than 0.05 and the natural complex extract is less than 0.1, the effect of improving the skin condition may not be sufficiently exhibited. On the other hand, if the sea buckthorn fruit extract exceeds 0.2 parts by weight or the natural complex extract exceeds 0.5 parts by weight, it may cause skin irritation and reduce skin safety.
본 발명에서 피부 개선은 피부 미백, 피부 주름 개선, 피부 재생, 피부 보습 개선 및 외부 자극에 의한 손상 피부 장벽 개선 중 어느 하나 이상을 포함할 수 있다. Skin improvement in the present invention may include any one or more of skin whitening, skin wrinkle improvement, skin regeneration, skin moisturizing improvement, and skin barrier improvement caused by external stimulation.
본 발명의 일 실시예에서 피부 재생 및 주름 개선을 통한 노화 방지 효능을 확인하기 위하여 활성산소 제거 효능을 측정한 결과, 비타민 혼합물에 산지나무 열매 추출물 및 천연 복합 추출물을 혼합에 따라 항산화 효능이 향상됨을 확인하였다(표 6). In one embodiment of the present invention, as a result of measuring the effect of removing active oxygen in order to confirm the anti-aging effect through skin regeneration and wrinkle improvement, it was found that the antioxidant effect was improved by mixing the acid chinensis fruit extract and natural complex extract with the vitamin mixture. confirmed (Table 6).
또한 본 발명의 일 실시예에서 색소 침착 및 이를 통한 피부 미백 효능을 확인한 결과 멜라닌 형성 저해 효과가 우수하게 나타났으며, 인체 실험을 통해 일정 기간 도포한 결과, 피부의 색소침착 및 피부 밝기 개선에 효과적임을 확인하였다(표 8 및 도 2). In addition, as a result of confirming pigmentation and skin whitening efficacy through it in one embodiment of the present invention, the melanin formation inhibitory effect was excellent, and as a result of application for a certain period of time through human experiments, it was effective in improving skin pigmentation and skin brightness. It was confirmed that (Table 8 and Figure 2).
상기 화장료 조성물의 제형은 특별히 제한되는 바가 없으며, 예를 들어, 용액, 외용 연고, 크림, 리퀴드, 폼, 영양 화장수, 유연 화장수, 팩, 유연수, 바디워시, 유액, 메이크업 베이스, 에센스, 비누, 액체 세정료, 입욕제, 선 스크린 크림, 선 오일, 현탁액, 유탁액, 페이스트, 겔, 로션, 파우더, 비누, 폼 클렌징, 오일, 분말 파운데이션, 유탁액 파운데이션, 왁스 파운데이션, 패치 및 스프레이 중 어느 하나의 제형을 가질 수 있다.The formulation of the cosmetic composition is not particularly limited. For example, solutions, external ointments, creams, liquids, foams, nourishing lotions, softening lotions, packs, softening water, body washes, emulsions, makeup bases, essences, soaps, liquids Any one of detergents, bath additives, sunscreen creams, sun oils, suspensions, emulsions, pastes, gels, lotions, powders, soaps, foam cleansing, oils, powder foundations, emulsion foundations, wax foundations, patches and sprays can have
상기 화장료의 조성물은 화장료의 제형 또는 사용 목적에 맞게 임의로 선정한 물질을 첨가할 수 있다. 예를 들어, 정제수, 유분, 계면활성제, 보습제, 고급알코올, 증저점제, 킬레이트제, 색소, 지방산, 산화방지제, 방부제, 왁스, pH조절제, 향료 등이 첨가될 수 있으나, 이에 제한되지 않을 수 있다.The composition of the cosmetic may be added to the material selected arbitrarily according to the formulation or purpose of use of the cosmetic. For example, purified water, oil, surfactants, moisturizers, higher alcohols, thickeners, chelating agents, pigments, fatty acids, antioxidants, preservatives, waxes, pH adjusters, fragrances, etc. may be added, but may not be limited thereto. there is.
상기 화장료 조성물의 제형이 페이스트, 크림 또는 젤인 경우, 담체 성분으로서 동물성유, 식물성유, 왁스, 파라핀, 전분, 트라칸트, 셀룰로오스 유도체, 폴리에틸렌 글리콜, 실리콘, 벤토나이트, 실리카, 탈크 또는 산화아연 등을 포함할 수 있으나 이에 제한되지 않을 수 있다.When the formulation of the cosmetic composition is a paste, cream or gel, animal oil, vegetable oil, wax, paraffin, starch, tracanth, cellulose derivative, polyethylene glycol, silicone, bentonite, silica, talc or zinc oxide are included as carrier components may be, but may not be limited thereto.
상기 화장료 조성물의 제형이 파우더 또는 스프레이인 경우, 담체 성분으로서 락토스, 탈크, 실리카, 알루미늄 히드록시드, 칼슘 실리게이트 또는 폴리아미드 파우더를 포함할 수 있고, 특히 스프레이인 경우 추가적으로 클로로플루오로히드로카본, 프로판/부탄 또는 디메틸 에테르와 같은 추진제를 포함할 수 있으나, 이에 제한되지 않을 수 있다. When the formulation of the cosmetic composition is a powder or spray, it may include lactose, talc, silica, aluminum hydroxide, calcium silicate or polyamide powder as a carrier component, especially in the case of a spray, additionally chlorofluorohydrocarbon, propellants such as, but not limited to, propane/butane or dimethyl ether.
상기 화장료 조성물의 제형이 용액 또는 유탁액인 경우, 담체 성분으로서 용매, 용해화제 또는 유탁화제를 포함할 수 있고, 예를 들어, 물, 에탄올, 이소프로판올, 에틸 카보네이트, 에틸 아세테이트, 벤질 알코올, 벤질 벤조에이트, 프로필렌글리콜, 1,3-부틸글리콜 오일, 글리세롤 지방족 에스테르, 폴리에틸렌 글리콜 또는 소르비탄의 지방산 에스테르를 포함할 수 있으나, 이에 제한되지 않을 수 있다. When the formulation of the cosmetic composition is a solution or emulsion, it may contain a solvent, a solubilizing agent or an emulsifying agent as a carrier component, for example, water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzo ate, propylene glycol, 1,3-butyl glycol oil, glycerol aliphatic esters, polyethylene glycol, or sorbitan fatty acid esters may be included, but may not be limited thereto.
상기 화장료 조성물의 제형이 현탁액인 경우, 담체 성분으로서 물, 에탄올 또는 프로필렌글리콜과 같은 액상의 희석제, 에톡실화 이소스테아릴 알코올, 폴리옥시에틸렌 소르비톨 에스테르 및 폴리옥시에틸렌 소르비탄 에스테르와 같은 현탁제, 미소 결정성 셀룰로오스, 알루미늄 메타히드록시드, 벤토나이트, 아가 또는 트라칸트 등을 포함할 수 있으나, 이에 제한되지 않을 수 있다.When the formulation of the cosmetic composition is a suspension, as a carrier component, a liquid diluent such as water, ethanol or propylene glycol, a suspending agent such as ethoxylated isostearyl alcohol, polyoxyethylene sorbitol ester and polyoxyethylene sorbitan ester; It may include crystalline cellulose, aluminum metahydroxide, bentonite, agar or tracanth, and the like, but may not be limited thereto.
상기 화장료 조성물의 제형이 계면-활성제 함유 클렌징인 경우, 담체 성분으로서 지방족 알코올 설페이트, 지방족 알코올 에테르 설페이트, 설포숙신산 모노에스테르, 이세티오네이트, 이미다졸리늄 유도체, 메틸타우레이트, 사르코시네이트, 지방산 아미드 에테르 설페이트, 알칼아미도베타인, 지방족 알코올, 지방산 글리세리드, 지방산 디에탄올아미드, 식물성유, 라놀린 유도체 또는 에톡실화 글리세롤 지방산 에스테르 등을 포함할 수 있으나, 이에 제한되지 않을 수 있다.When the formulation of the cosmetic composition is surfactant-containing cleansing, as a carrier component, aliphatic alcohol sulfate, aliphatic alcohol ether sulfate, sulfosuccinic acid monoester, isethionate, imidazolinium derivative, methyl taurate, sarcosinate, fatty acid Amide ether sulfates, alkalamidobetaines, fatty alcohols, fatty acid glycerides, fatty acid diethanolamides, vegetable oils, lanolin derivatives, or ethoxylated glycerol fatty acid esters may be included, but may not be limited thereto.
본 발명의 조성물은 피부에 직접 도포하거나 살포하는 등의 경피 투여 방법으로 사용될 수 있으며, 본 발명 조성물의 투여 경로는 목적조직에 도달할 수 있는 한 어떠한 일반적인 경로를 통하여 투여될 수 있다. The composition of the present invention can be used as a transdermal administration method such as direct application or spraying to the skin, and the administration route of the composition of the present invention can be administered through any general route as long as it can reach the target tissue.
본 발명의 조성물의 사용량은 연령, 병변의 정도 등의 개인 차이나 제형에 따라 적절하게 조절될 수 있으며, 1일 1회 내지 수회 적?韜?을 피부에 도포하여 1 주일 내지 수개월 사용될 수 있다.The amount of use of the composition of the present invention may be appropriately adjusted according to individual differences such as age, severity of lesions, etc., or formulation, and may be applied to the skin once to several times a day and used for one week to several months.
본 발명의 화장료 조성물은 피부 보습, 피부 장벽 개선, 피부 주름 개선 및 피부 미백 개선할 수 있는 효과를 가지므로, 피부 노화 장지 및 피부 상태 개선 용도로 활용될 수 있다. Since the cosmetic composition of the present invention has effects of moisturizing skin, improving skin barrier, improving skin wrinkles, and improving skin whitening, it can be used for preventing skin aging and improving skin conditions.
본 발명의 효과는 상기한 효과로 한정되는 것은 아니며, 본 발명의 상세한 설명 또는 청구범위에 기재된 발명의 구성으로부터 추론 가능한 모든 효과를 포함하는 것으로 이해되어야 한다. The effects of the present invention are not limited to the above effects, and should be understood to include all effects that can be inferred from the detailed description of the present invention or the configuration of the invention described in the claims.
도 1은 실시예를 이용한 화장료 조성물(화장수)의 제조 공정을 나타낸 것이다.
도 2는 실시예의 화장료 조성물을 피부에 도포한 후 미백 효과를 촬영한 결과를 나타낸 것이다(A: 실시예 1, B: 실시예 2)1 shows a manufacturing process of a cosmetic composition (toilet lotion) using an embodiment.
Figure 2 shows the results of photographing the whitening effect after applying the cosmetic composition of Example to the skin (A: Example 1, B: Example 2)
이하, 본 발명을 실시예에 의해 상세히 설명한다. 단, 하기 실시예는 본 발명을 예시하는 것일 뿐, 본 발명이 하기 실시예에 의해 한정되는 것은 아니다.Hereinafter, the present invention will be described in detail by examples. However, the following examples are only to illustrate the present invention, and the present invention is not limited by the following examples.
실시예 1. 화장료 조성물의 제조Example 1. Preparation of cosmetic composition
실시예 1-1 천연 추출물의 준비Example 1-1 Preparation of Natural Extract
사과를 정제수로 세척하고 분쇄기로 분쇄하였다. 상기 사과 분쇄물 100 g, 증류수 400 g, Rhizopus속 계열의 가수분해 효소(일본 ㈜초임계기술연구소, 제품 명 효소 복합체D) 1 g을 혼합하여 추출용 혼합물을 형성하였다. 상기 추출용 혼합물을 100 MPa, 37 ℃의 온도로 24 시간동안 효소 가수분해 처리하여 추출 조성물을 형성하였다. 상기 추출 조성물을 40 메쉬(mesh)의 필터로 여과하여 액상 성분인 사과 추출액을 회수하였다.Apples were washed with purified water and ground with a grinder. A mixture for extraction was formed by mixing 100 g of the apple ground material, 400 g of distilled water, and 1 g of a hydrolytic enzyme of the genus Rhizopus (Japan Supercritical Research Institute, product name Enzyme Complex D). The extraction mixture was subjected to enzymatic hydrolysis at 100 MPa and 37 °C for 24 hours to form an extraction composition. The extract composition was filtered through a 40 mesh filter to recover apple extract, which is a liquid component.
산자나무열매, 자초 및 폴스아르니카 꽃은 수확하여 건조시킨 것을 국내 시중에서 구입하였다. 분쇄한 산자나무열매, 자초, 폴스아르니카 꽃 100 g에 70% 에탄올 300 kg을 가하고 85~90℃에서 2시간 동안 추출한 후 여과, 감압 농축하여 산자나무열매 70% 에탄올 추출물, 자초 70% 에탄올 추출물, 폴스아르니카 꽃 70% 에탄올 추출물을 얻었다. Sea buckthorn berries, self-pollinated flowers, and false arnica flowers were harvested and dried and purchased from the domestic market. 300 kg of 70% ethanol was added to 100 g of crushed sea buckthorn fruit, wild buckthorn, and Falls arnica flowers, extracted at 85-90 ° C for 2 hours, filtered, and concentrated under reduced pressure to obtain 70% ethanol extract of sea buckthorn fruit, 70% ethanol extract of self plant, A 70% ethanol extract of False Arnica flowers was obtained.
실시예 1-2 아스타잔틴, 비타민 혼합물의 준비Example 1-2 Preparation of astaxanthin and vitamin mixture
아스타잔틴 및 비타민 혼합물은 식물 또는 합성으로 생산한 제품을 시중에서 구입하였으며, 다른 동물성 성분이 함유된 제품을 원료로 사용하지 않았다. Astaxanthin and vitamin mixtures were purchased from plants or synthetically produced products, and products containing other animal ingredients were not used as raw materials.
실시예 1-3 화장료 조성물의 제조Example 1-3 Preparation of Cosmetic Composition
유화제(하이드로제니이티드레시틴 및 폴리글리세릴-10 스테아레이트)를 80~85℃의 온도에서 첨가한 뒤, 40~50℃의 온도에서 정제수 및 보습제(글리세린)을 혼합하여 제조하였다. 이후 비타민 혼합물(소듐아스코빌포스페이트, 나이아신아마이드, 판테놀, 바이오틴, 티아민에이치씨엘, 피리독신, 토코페릴아세테이트, 레티닐팔미테이트, 폴릭애씨드, 사이아노코발아민), 아스타잔틴, 산자나무열매 추출물 및 천연 복합 추출물(사과 추출물 및 자초나무)을40~50℃의 온도에서 혼합한 뒤, 초고압 반응 장치(일본 동양고압사)를 이용하여 100MPa에서 균질화하였다. 이를 3회 반복하였다. It was prepared by adding emulsifiers (hydrogenated lecithin and polyglyceryl-10 stearate) at a temperature of 80 to 85°C, and then mixing purified water and a moisturizer (glycerin) at a temperature of 40 to 50°C. Then vitamin mixture (sodium ascorbyl phosphate, niacinamide, panthenol, biotin, thiamine HCL, pyridoxine, tocopheryl acetate, retinyl palmitate, polyacid, cyanocobalamin), astaxanthin, sea buckthorn berry extract and natural After mixing the composite extracts (apple extract and japonica) at a temperature of 40 to 50 ° C., they were homogenized at 100 MPa using an ultra-high pressure reaction device (Toyo High Pressure Co., Japan). This was repeated 3 times.
실시예 2. 화장료 조성물의 제조Example 2. Preparation of cosmetic composition
유화제(하이드로제니이티드레시틴 및 폴리글리세릴-10 스테아레이트)를 80~85℃의 온도에서 첨가한 뒤, 40~50℃의 온도에서 정제수 및 보습제(글리세린)을 혼합하여 제조하였다. 이후 비타민 혼합물(소듐아스코빌포스페이트, 나이아신아마이드, 판테놀, 바이오틴, 티아민에이치씨엘, 피리독신, 토코페릴아세테이트, 레티닐팔미테이트, 폴릭애씨드, 사이아노코발아민), 아스타잔틴, 산자나무열매 추출물 및 천연 복합 추출물(사과 추출물, 자초 추출물 및 폴스아르니카 꽃 추출물)을40~50℃의 온도에서 혼합한 뒤, 초고압 반응 장치(일본 동양고압사)를 이용하여 100MPa에서 균질화하였다. 이를 3회 반복하였다. It was prepared by adding emulsifiers (hydrogenated lecithin and polyglyceryl-10 stearate) at a temperature of 80 to 85°C, and then mixing purified water and a moisturizer (glycerin) at a temperature of 40 to 50°C. Then vitamin mixture (sodium ascorbyl phosphate, niacinamide, panthenol, biotin, thiamine HCL, pyridoxine, tocopheryl acetate, retinyl palmitate, polyacid, cyanocobalamin), astaxanthin, sea buckthorn berry extract and natural After mixing the composite extracts (apple extract, self-injection extract, and Falls Arnica flower extract) at a temperature of 40 to 50 ° C., they were homogenized at 100 MPa using an ultra-high pressure reaction device (Toyo High Pressure Co., Japan). This was repeated 3 times.
비교예 1. 화장료 조성물의 제조Comparative Example 1. Preparation of cosmetic composition
실시예 1과 제조방법은 동일하며, 다만 천연 복합 추출물(산자나무열매 추출물, 사과 추출물 및 자초나무)을 포함하지 않았다.The manufacturing method is the same as in Example 1, except that natural complex extracts (Sea buckthorn fruit extract, apple extract, and japonica japonica) were not included.
비교예 2. 화장료 조성물의 제조Comparative Example 2. Preparation of cosmetic composition
실시예 1과 제조방법은 동일하며, 다만 천연 복합 추출물 중 산자나무열매 추출물만을 포함하였다.The preparation method was the same as in Example 1, except that only the sea buckthorn fruit extract among the natural complex extracts was included.
실험예 1. 항산화 효능 측정Experimental Example 1. Antioxidant efficacy measurement
상기 실시예 및 비교예에서 제조된 화장료 조성물 각각에 10배의 증류수를 혼합하여 희석함으로써 시료들을 제조하고, 각각의 시료들에 대해 DPPH(1, 1-diphenyl-2pierylhydrazyl, Sigma-Aldrich, St. Louis, MO, USA) 라디칼 소거능을 Blois(1958)변법에 의하여 측정하였다. 측정 방법은 다음과 같다. 각각의 희석 시료 100uL에 1.5X10-4M DPPH 용액 100Ul을 가하여 실온의 암실에서 30분간 정치한 후, 520nm에서 흡광도를 측정하였으며, 측정한 DPPH 라디칼 소거능 측정 결과는 표 6에 나타내었다. Samples were prepared by mixing and diluting each of the cosmetic compositions prepared in the above Examples and Comparative Examples with 10-fold distilled water, and DPPH (1, 1-diphenyl-2pierylhydrazyl, Sigma-Aldrich, St. Louis) for each sample. , MO, USA) The radical scavenging ability was measured according to the Blois (1958) method. The measurement method is as follows. 100Ul of 1.5X10 -4 M DPPH solution was added to 100uL of each diluted sample, allowed to stand in a dark room at room temperature for 30 minutes, and then absorbance was measured at 520nm.
상기 표 6에 나타낸 바와 같이, 실시예의 화장료 조성물이 비교예의 화장료 조성물과 비교하여 더욱 향상된 DPPH 라디칼 소거 활성을 나타낸 것을 확인할 수 있다. 즉, 이것은 기존 고함량의 비타민 함유 화장료 조성물 대비 천연 복합 추출물을 포함한 화장료 조성물이 뛰어난 항산화 효과를 가지는 것을 보여주는 것이다.As shown in Table 6, it can be confirmed that the cosmetic compositions of Examples showed more improved DPPH radical scavenging activity compared to the cosmetic compositions of Comparative Examples. That is, this shows that the cosmetic composition including the natural complex extract has an excellent antioxidant effect compared to the existing high-content vitamin-containing cosmetic composition.
실험예 2. 피부 보습 및 장벽 강화 효능 확인 Experimental Example 2. Confirmation of skin moisturizing and barrier strengthening efficacy
HaCaT 세포를 24 웰 플레이트에 1.0 × 105 cells/mL로 분주하여 37℃, 5% CO2 조건에서 18시간 동안 배양하였다. 무혈청 DMEM으로 교환하고 시료를 처리하여 24시간 동안 배양하였다. 이후 각 군마다 배양액 제거 및 PBS로 세척 후 단백질 정량에 영향을 줄 수 있는 약물이 포함되지 않은 PBS를 처리하였다. 이는 저온, 상온 인큐베이션을 반복하여 세포를 용해시킨 후 단백질을 수거하였다. 정량은 Filaggrin-ELISA kit (Elabscience Biotechnology Co.,Ltd )를 이용하였으며 제조사에서 제공한 방법에 의해 진행하였다.HaCaT cells were dispensed in a 24-well plate at 1.0 × 10 5 cells/mL and cultured for 18 hours at 37°C and 5% CO 2 conditions. After exchanging with serum-free DMEM, the samples were treated and incubated for 24 hours. Thereafter, each group was treated with PBS that did not contain drugs that could affect protein quantification after removing the culture medium and washing with PBS. Cells were lysed by repeated low-temperature and room-temperature incubation, and then proteins were collected. Quantification was performed using a Filaggrin-ELISA kit (Elabscience Biotechnology Co., Ltd) and performed according to the method provided by the manufacturer.
그 결과, 상기 실시예 1, 2의 경우 필라그린의 발현량이 비교예 2 대비 10% 이상 증가하였으며, 사과 추출물, 자초 추출물 및/또는 폴스아르니카 꽃 추출물의 함유에 따라 피부 보습 및 피부 장벽개선 효과가 향상됨을 확인하였다. As a result, in the case of Examples 1 and 2, the expression level of filaggrin increased by 10% or more compared to Comparative Example 2, and the skin moisturizing and skin barrier improvement effects were obtained according to the inclusion of apple extract, self-injection extract and / or false arnica flower extract. improvement was confirmed.
실험예 3. 피부 주름 개선 및 미백 효과 측정Experimental Example 3. Measurement of skin wrinkle improvement and whitening effect
3-1. 멜라닌 저해활성 실험 확인 3-1. Confirmation of melanin inhibitory activity test
멜라닌 함량 분석(melanin contents assay)를 통해 실시예 및 비교예의 시료에 의한 멜라닌 형성 저해능을 평가하였다.Melanin formation inhibitory ability by the samples of Examples and Comparative Examples was evaluated through a melanin contents assay.
먼저 실시예 및 비교예의 시료를 정제수에 50 mg/L 농도로 각각 현탁한 후 멜라닌 생성량을 평가하였다. 60 mm 컬쳐 디쉬(culture dish)에 B16F10 세포를 1.5X105 cells/well의 농도로 접종한 후 24시간 동안 배양하였다. 멜라닌 형성을 촉진하는 호르몬인 α-MSH(Sigma-Aldrich, St. Louis, MO, USA)와 실시예 및 비교예의 시료를 50 mg/L 농도로 배지에 투입하였다(Virador VM et al, 1999).First, samples of Examples and Comparative Examples were suspended in purified water at a concentration of 50 mg/L, respectively, and melanin production was evaluated. B16F10 cells were inoculated in a 60 mm culture dish at a concentration of 1.5X10 5 cells/well and cultured for 24 hours. α-MSH (Sigma-Aldrich, St. Louis, MO, USA), a hormone that promotes melanin formation, and samples of Examples and Comparative Examples were added to the medium at a concentration of 50 mg/L (Virador VM et al, 1999).
48시간 경과 후, 세포를 수확하여 PBS로 1회 세척한 후 1N NaOH 용출 버퍼 120 uL를 넣고 95℃에서 10분간 가열하여 세포를 용해하였다. 마이크로플레이트 리더(microplate reader)를 이용하여 450 nm 파장에서 픕광도를 측정하였으며, 대조군으로 100 ug/mL 농도의 알부틴(albutin)을 사용하였다.After 48 hours, the cells were harvested, washed once with PBS, and then 120 uL of 1N NaOH elution buffer was added and heated at 95° C. for 10 minutes to dissolve the cells. The light intensity was measured at a wavelength of 450 nm using a microplate reader, and arbutin at a concentration of 100 ug/mL was used as a control.
[식 1][Equation 1]
멜라닌 생성 억제율(%) = 100X(1-(각 시험물질의 흡광도/대조군의 흡광도))Melanin production inhibition rate (%) = 100X (1-(absorbance of each test substance/absorbance of control group))
3-2. 피부 주름 개선 및 미백 효과 설문 평가 3-2. Skin wrinkle improvement and whitening effect questionnaire evaluation
상기 실시예 및 비교예에서 제조된 화장료 조성물의 피부 주름 개선 및 미백 효과를 기호도 평가를 통해 확인하였다. 실험은 선발 기준에 부합하고 면제 기준에 포함되지 않는 만 30세 내지 45세의 남녀 40명을 대상으로 하였으며, 각각 10명씩 나누어 8주 동안 1일 1회, 자가 도포 방법으로 적용한 뒤 전반적인 만족감에 대하여 피험자가 느끼는 기호도를 평가하였다. 평가 기준은 매우 효과가 있다(5점), 효과가 있다(4점), 보통이다(3점), 효과가 없다(2점), 전혀 효과가 없다(1점)으로 하여 그 결과를 하기 표 9에 나타내었다.The skin wrinkle improvement and whitening effects of the cosmetic compositions prepared in Examples and Comparative Examples were confirmed through preference evaluation. The experiment targeted 40 men and women aged 30 to 45 who met the selection criteria and were not included in the exemption criteria, divided into 10 people each and applied once a day for 8 weeks as a self-application method, and overall satisfaction The degree of preference felt by the subject was evaluated. The evaluation criteria are very effective (5 points), effective (4 points), moderate (3 points), no effect (2 points), and not effective at all (1 point), and the results are shown in the table below. 9.
또한 실시예의 화장료 조성물 도포 후 결과를 도 2에 나타내었다.In addition, the results after application of the cosmetic composition of Example are shown in FIG.
실험예 4. 피부 안정성 평가Experimental Example 4. Evaluation of skin stability
상기 실시예 및 비교예에서 제조된 화장료 조성물들의 안정성 평가를 실시하였다. 안정성 평가는 제조된 화장료 조성물들을 각각 상온(25℃) 및 상온 이상(50℃)에서 3개월 동안 방치하였을 때 성분의 분리 현상이 나타나는지를 육안으로 판정하였다. 판정 기준은 분리 현상이 일어난 경우 '불안정', 분리 현상이 일어나지 않은 경우 '안정'으로 기재하였다. 안정성 평가 결과는 하기 표 10에 나타내었다.The stability of the cosmetic compositions prepared in Examples and Comparative Examples was evaluated. In the stability evaluation, it was visually determined whether component separation occurred when the prepared cosmetic compositions were left at room temperature (25° C.) and above room temperature (50° C.) for 3 months, respectively. The criterion for determination was 'unstable' when separation occurred, and 'stable' when separation did not occur. The stability evaluation results are shown in Table 10 below.
상기 표 10에 나타낸 바와 같이, 본 발명에 따른 실시예의 화장료 조성물은 50℃의 온도에서 3개월동안 방치 시 분리 현상이 일어나지 않음을 확인하였으며, 상온 및 상온 이상에서 장기 보관 시에도 분리 현상 없이 안정하다는 것을 확인할 수 있었다.전술한 본 발명의 설명은 예시를 위한 것이며, 본 발명이 속하는 기술 분야의 통상의 지식을 가진 자는 본 발명의 기술적 사상이나 필수적인 특징을 변경하지 않고서 다른 구체적인 형태로 쉽게 변형이 가능하다는 것을 이해할 수 있을 것이다. 그러므로 이상에서 기술한 실시 예들은 모든 면에서 예시적인 것이며 한정적이 아닌 것으로 이해해야만 한다. 예를 들어, 단 일형으로 설명되어 있는 각 구성 요소는 분산되어 실시될 수도 있으며, 마찬가지로 분산된 것으로 설명되어 있는 구성 요소들도 결합된 형태로 실시될 수 있다.As shown in Table 10, it was confirmed that the cosmetic compositions of Examples according to the present invention did not cause separation when left at a temperature of 50 ° C. for 3 months, and were stable without separation even when stored for a long time at room temperature or above room temperature. It was confirmed that the above description of the present invention is for illustrative purposes, and those skilled in the art can easily modify it into other specific forms without changing the technical spirit or essential features of the present invention. you will understand that Therefore, the embodiments described above should be understood as illustrative in all respects and not limiting. For example, each component described as a single type may be implemented in a distributed manner, and similarly, components described as distributed may also be implemented in a combined form.
본 발명의 범위는 후술하는 청구범위에 의하여 나타내어지며, 청구범위의 의미 및 범위 그리고 그 균등 개념으로부터 도출되는 모든 변경 또는 변형된 형태가 본 발명의 범위에 포함되는 것으로 해석되어야 한다.The scope of the present invention is indicated by the following claims, and all changes or modifications derived from the meaning and scope of the claims and equivalent concepts should be interpreted as being included in the scope of the present invention.
Claims (5)
상기 비타민 혼합물은 소듐아스코빌포스페이트(Sodium Ascorbyl Phosphate), 나이아신아마이드(Niacinamide), 판테놀(Panthenol), 바이오틴(Biotin), 티아민(Thiamine), 피리독신(Pyridoxine), 토코페릴아세테이트(Tocopheryl Acetate), 레티닐팔미테이트(Retinyl Palmitate), 폴릭애씨드(Folic Acid) 및 사이아노코발아민(Cyanocobalamin)을 포함하고,
상기 천연 복합 추출물은 사과 추출물 및 자초 추출물을 포함하는 것인, 피부 개선용 화장료 조성물.A cosmetic composition for skin improvement comprising a sea buckthorn fruit extract, a vitamin mixture, astaxanthin and a natural complex extract,
The vitamin mixture is Sodium Ascorbyl Phosphate, Niacinamide, Panthenol, Biotin, Thiamine, Pyridoxine, Tocopheryl Acetate, Retinyl Contains Retinyl Palmitate, Folic Acid and Cyanocobalamin,
The natural complex extract is a cosmetic composition for skin improvement comprising an apple extract and a self-inflicted extract.
상기 천연 복합 추출물은 폴스아르니카 꽃 추출물을 추가로 포함하는, 피부 개선용 화장료 조성물. According to claim 1,
The natural complex extract further comprises a false arnica flower extract, a cosmetic composition for improving skin.
상기 화장료 조성물 100 중량부에 대하여, 산자나무열매 추출물 0.05 내지 0.2 중량부, 천연 복합 추출물 0.1 내지 0.5 중량부 및 비타민 혼합물 1.5 내지 3 중량부를 포함하는, 피부 개선용 화장료 조성물. According to claim 1,
A cosmetic composition for skin improvement comprising 0.05 to 0.2 parts by weight of sea buckthorn fruit extract, 0.1 to 0.5 parts by weight of a natural complex extract, and 1.5 to 3 parts by weight of a vitamin mixture, based on 100 parts by weight of the cosmetic composition.
상기 화장료 조성물에서 천연 복합 추출물은 사과 추출물 및 자초 추출물이 1 : 0.5 내지 1 : 1 의 비율로 혼합되는 것인, 피부 개선용 화장료 조성물. According to claim 3,
In the cosmetic composition, the natural composite extract is an apple extract and a self-injection extract mixed in a ratio of 1: 0.5 to 1: 1, a cosmetic composition for improving skin.
상기 피부 개선은 피부 미백, 피부 주름 개선, 피부 재생, 피부 보습 개선 및 외부 자극에 의한 손상 피부 장벽 개선 중 어느 하나 이상인 것인, 피부 개선용 화장료 조성물. According to claim 1,
The skin improvement is any one or more of skin whitening, skin wrinkle improvement, skin regeneration, skin moisturizing improvement and improvement of damaged skin barrier caused by external stimulation, a cosmetic composition for improving skin.
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