KR102454995B1 - Composition for improving hangover and method for manufacturing the same - Google Patents
Composition for improving hangover and method for manufacturing the same Download PDFInfo
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- KR102454995B1 KR102454995B1 KR1020220000771A KR20220000771A KR102454995B1 KR 102454995 B1 KR102454995 B1 KR 102454995B1 KR 1020220000771 A KR1020220000771 A KR 1020220000771A KR 20220000771 A KR20220000771 A KR 20220000771A KR 102454995 B1 KR102454995 B1 KR 102454995B1
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- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
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- A—HUMAN NECESSITIES
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- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/20—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents
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- A23L29/244—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents of vegetable origin from corms, tubers or roots, e.g. glucomannan
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/135—Bacteria or derivatives thereof, e.g. probiotics
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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- A23V2200/00—Function of food ingredients
- A23V2200/30—Foods, ingredients or supplements having a functional effect on health
- A23V2200/334—Foods, ingredients or supplements having a functional effect on health treating the effects of consuming alcohol, narcotics or other addictive behavior, e.g. treating hangover or reducing blood alcohol levels
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
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Abstract
Description
본 발명은 숙취 개선용 식품 조성물 및 그 제조방법에 관한 것으로, 더 자세하게는, 다시마, 귤피, 칡꽃, 헛개나무, 대추, 구기자뿌리, 녹차어린잎, 사철쑥, 사인, 국화, 침향, 이소말토올리고당, D-l 멘톨, 유산균, 글루코만난 및 정제수를 혼합한 생약재혼합물을 포함하여 숙취 개선 효과를 갖도록 한 숙취 개선용 조성물 및 그 제조방법에 관한 것이다.The present invention relates to a food composition for alleviating a hangover and a method for producing the same, and more particularly, kelp, tangerine peel, arrowroot flower, hemp, jujube, goji root, green tea young leaf, wormwood, sage, chrysanthemum, aloes, isomaltooligosaccharide, D-1 It relates to a composition for improving a hangover, including a herbal medicine mixture mixed with menthol, lactic acid bacteria, glucomannan, and purified water, to have a hangover improvement effect, and a method for manufacturing the same.
알코올은 보통 세 가지 정도의 경로를 통하여 산화되는데， 첫째 위 점막 또는 간에 존재하는 알코올 탈수소효소(Alcoholo dehydrogenase, ADH) 의 작용，둘째 소포체에 존재하는 마이크로솜 에탄올 산화계(Microsomoaoloeotohoaono oxidizing system , MEOS) 작용， 셋째 퍼옥시솜(peroxisome) 에 존재하는 카탈라제(cata lrase)의 작용 등을 거쳐 이산화탄소(C02)와 물(H20)로 분해된다.Alcohol is usually oxidized through three pathways: first, the action of alcohol dehydrogenase (ADH) in the gastric mucosa or liver, second, the microsomal ethanol oxidizing system (MEOS) action in the endoplasmic reticulum; Third, it is decomposed into carbon dioxide (C0 2 ) and water (H 2 0) through the action of catalase present in the peroxisome.
특히, 신체에서 에탄올은 아세트알데히드로 처음 분해된 후 아세트산으로 분해되는데，고농도의 활성 화합물인 아세트알데히드는 발한(sweat), 급맥(rapid pulse), 피부발열 (skin flushing), 오심 (nausea) 그리고 구토(vomiting)를 유발할 수 있다 이러한 이유로 현대 대부분의 연구자는 알코올 분해 산물인 아세트알데히드가 숙취의 원인이라고 생각하고 있다.In particular, in the body, ethanol is first decomposed into acetaldehyde and then decomposed into acetic acid. Acetaldehyde, an active compound at a high concentration, causes sweating, rapid pulse, skin flushing, nausea and vomiting. (vomiting) For this reason, most modern researchers think that acetaldehyde, a product of alcohol breakdown, is the cause of a hangover.
다시 말해서, 알코올이 체내에 흡수되어 축적된 에틸알코올이나, 알코올의 분해과정에서 발생하는 아세트알데히드 또는 술 자체에 함유된 극소량의 메틸알코올에 의해 간세포와 뇌세포가 손상을 입게 되며, 체내에 상기 에틸알코올이나 아세트알데히드 또는 메틸알코올이 과다 축적되는 경우 체내의 신진대사 등에 장애가 발생하여 구토, 두통, 전신무력감, 피로감, 소화불량 등이 일어나고, 심한 경우 오한이나 복통, 위장장애 등을 일으키는 숙취현상을 유발하게 된다.In other words, hepatocytes and brain cells are damaged by ethyl alcohol that is absorbed and accumulated in the body, acetaldehyde generated during the decomposition process of alcohol, or methyl alcohol contained in alcohol itself, and the ethyl alcohol in the body When alcohol, acetaldehyde, or methyl alcohol accumulates excessively, the metabolism in the body is disturbed, causing vomiting, headache, general weakness, fatigue, indigestion, etc. will do
이와 같은 숙취현상으로 인해 바쁜 현대인들의 일상적인 생활이 제대로 이루어지지 않으며, 본인은 물론 본인과 관련 있는 타인에게 업무적으로 영향을 주거나, 본인과 관련이 없는 타인에게도 불쾌감을 주는 등 숙취를 원인으로 하는 부정적인 결과가 크게 나타나고 있다.Due to such a hangover phenomenon, the daily life of busy modern people is not performed properly, and the cause of hangovers, such as affecting the person as well as others related to the person, or causing discomfort to others not related to the person himself/herself There are significant negative results.
상기와 같은 숙취를 해결하기 위해 종래에는 간 기능을 개선하는 약재 등을 이용한 차나 음료 등을 섭취하거나, 뜨겁고 매운 해장국을 섭취하는 것이 일반적이었으나, 상기의 방법들은 그 효과가 검증된 바 없을 뿐만 아니라 특히 해장국을 섭취하는 것은 위에 부담을 주어 위암이 발생할 확률을 높이게 된다.In order to solve the hangover as described above, conventionally, it has been common to consume tea or beverages using drugs that improve liver function, or to consume hot and spicy haejangguk, but the above methods have not only been proven effective but also particularly Consuming haejangguk puts a strain on the stomach and increases the risk of stomach cancer.
이러한 문제점들을 해결하기 위한 것으로 여러 약재를 혼합하여 만든 음료들이 개발, 판매되고 있다. 숙취해소를 위해 여러 약재를 이용하여 다양한 방법으로 숙취해소용 음료를 개발 및 제조하고 있고 각각의 제조방법이나 음료마다 특이성이 있으나, 아직까지는 제조되는 음료들로부터 충분한 숙취해소 효과를 기대하기 어려워, 추가적인 연구가 필요한 상황이다. In order to solve these problems, beverages made by mixing various drugs are being developed and sold. For hangover relieving, hangover relieving beverages are developed and manufactured in various ways using various medicinal substances, and each manufacturing method or beverage has specificity, but it is difficult to expect a sufficient hangover relieving effect from beverages manufactured so far. research is needed.
상기와 같은 문제점을 해결하기 위하여 본 발명은 다시마, 귤피, 칡꽃, 헛개나무, 대추, 구기자뿌리, 녹차어린잎, 사철쑥, 사인, 국화, 침향, 이소말토올리고당, D-l 멘톨, 유산균, 글루코만난 및 정제수를 혼합한 생약재혼합물을 포함하여 숙취 개선 효과를 갖도록 한 숙취 개선용 조성물 및 그 제조방법을 제공하는데 목적이 있다.In order to solve the above problems, the present invention uses kelp, tangerine peel, arrowroot flower, kohlrabi, jujube, goji root, green tea young leaf, wormwood, coriander, chrysanthemum, aloes, isomaltooligosaccharide, D-l menthol, lactic acid bacteria, glucomannan and purified water. An object of the present invention is to provide a composition for improving a hangover, and a method for preparing the same, including a mixed herbal medicine mixture to have a hangover improvement effect.
상기와 같은 목적을 달성하기 위하여 본 발명은 다시마, 귤피, 칡꽃, 헛개나무, 대추, 구기자뿌리, 녹차어린잎, 사철쑥, 사인, 국화, 침향, 이소말토올리고당, D-l 멘톨, 유산균, 글루코만난 및 정제수를 혼합한 생약재혼합물을 포함하는 것을 특징으로 하는 숙취 개선용 조성물을 제공한다.In order to achieve the above object, the present invention is a kelp, tangerine peel, arrowroot flower, horseradish tree, jujube, goji berry root, green tea young leaf, wormwood, coriander, chrysanthemum, aloes, isomaltooligosaccharide, D-l menthol, lactic acid bacteria, glucomannan and purified water. It provides a composition for improving hangover, characterized in that it comprises a mixed herbal medicine mixture.
또한, 상기 다시마, 귤피, 칡꽃, 헛개나무, 대추, 구기자뿌리, 녹차어린잎, 사철쑥, 사인, 국화, 침향, 이소말토올리고당, D-l 멘톨, 유산균, 글루코만난 및 정제수는 각각 0.01 ~ 99.85중량%로 혼합되는 것을 특징으로 한다.In addition, the kelp, tangerine peel, arrowroot flower, kelp tree, jujube, goji berry root, green tea young leaf, wormwood, sage, chrysanthemum, amethyst, isomaltooligosaccharide, D-l menthol, lactic acid bacteria, glucomannan and purified water are each mixed at 0.01 to 99.85% by weight. characterized by being
또한, 상기 생약재혼합물을 각각 생약재농축액과 생약재분말로 제조하여 혼합한 것을 특징으로 한다.In addition, it is characterized in that the herbal medicine mixture is prepared and mixed with herbal medicine concentrate and herbal medicine powder, respectively.
또한, 다시마, 귤피, 칡꽃, 헛개나무, 대추, 구기자뿌리, 녹차어린잎, 사철쑥, 사인, 국화, 침향, 이소말토올리고당, D-l 멘톨, 유산균, 글루코만난 및 정제수를 혼합하여 생약재혼합물을 제조하고, 생약재혼합물로부터 생약재추출물을 추출하는 추출 단계(S10); 상기 추출 단계(S10)에서 추출된 생약재추출물을 농축하여, 생약재농축액을 제조하는 농축 단계(S20); 다시마, 귤피, 칡꽃, 헛개나무, 대추, 구기자뿌리, 녹차어린잎, 사철쑥, 사인, 국화, 침향, 이소말토올리고당, D-l 멘톨, 유산균, 글루코만난 및 정제수를 혼합하여 생약재혼합물을 제조하고, 건조 분쇄하여, 생약재분말을 제조하는 생약재분말 제조 단계(S30); 및, 상기 농축 단계(S20)에서 제조된 생약재농축액과 상기 생약재분말 제조 단계(S30)에서 제조된 생약제 분말을 혼합하여 시럽을 제조하는 시럽 제조단계(S41)를 포함하는 것을 특징으로 하는 숙취 개선용 조성물의 제조방법을 제공한다.In addition, kelp, tangerine peel, arrowroot flower, kelp tree, jujube, goji berry root, green tea young leaf, wormwood, sage, chrysanthemum, amethyst, isomaltooligosaccharide, D-l menthol, lactic acid bacteria, glucomannan and purified water are mixed to prepare a herbal medicine mixture, and herbal medicines Extraction step of extracting the herbal extract from the mixture (S10); Concentrating the herbal medicine extract extracted in the extraction step (S10) to prepare a herbal medicine concentrate (S20); Kelp, tangerine peel, arrowroot flower, honeysuckle, jujube, goji root, green tea young leaf, wormwood, sage, chrysanthemum, aloes, isomaltooligosaccharide, D-l menthol, lactic acid bacteria, glucomannan and purified water are mixed to prepare a herbal medicine mixture, dried and pulverized , herbal medicine powder manufacturing step (S30) of preparing the herbal medicine powder; and a syrup preparation step (S41) of mixing the herbal medicine concentrate prepared in the concentration step (S20) and the herbal medicine powder prepared in the herbal medicine powder preparation step (S30) to prepare a syrup (S41) for hangover improvement A method for preparing the composition is provided.
또한, 본 발명은 다시마, 귤피, 칡꽃, 헛개나무, 대추, 구기자뿌리, 녹차어린잎, 사철쑥, 사인, 국화, 침향, 이소말토올리고당, D-l 멘톨, 유산균, 글루코만난 및 정제수를 혼합하여 생약재혼합물을 제조하고, 생약재혼합물로부터 생약재추출물을 추출하는 추출 단계(S10); 상기 추출 단계(S10)에서 추출된 생약재추출물을 농축하여, 생약재농축액을 제조하는 농축 단계(S20); 다시마, 귤피, 칡꽃, 헛개나무, 대추, 구기자뿌리, 녹차어린잎, 사철쑥, 사인, 국화, 침향, 이소말토올리고당, D-l 멘톨, 유산균, 글루코만난 및 정제수를 혼합하여 생약재혼합물을 제조하고, 건조 분쇄하여, 생약재분말을 제조하는 생약재분말 제조 단계(S30); 및, 상기 농축 단계(S20)에서 제조된 생약재농축액과 상기 생약재분말 제조 단계(S30)에서 제조된 생약제 분말을 혼합하여 과립제, 산제 또는, 환제로 제조하는 약제 제조단계(S42)를 포함하는 것을 특징으로 하는 숙취 개선용 조성물의 제조방법을 제공한다.In addition, the present invention prepares a herbal medicine mixture by mixing kelp, tangerine peel, arrowroot flower, horseradish tree, jujube, goji root, green tea young leaf, wormwood, sage, chrysanthemum, aloes, isomaltooligosaccharide, D-1 menthol, lactic acid bacteria, glucomannan and purified water and extracting the herbal extract from the herbal material mixture (S10); Concentrating the herbal medicine extract extracted in the extraction step (S10) to prepare a herbal medicine concentrate (S20); Kelp, tangerine peel, arrowroot flower, honeysuckle, jujube, goji root, green tea young leaf, wormwood, sage, chrysanthemum, aloes, isomaltooligosaccharide, D-l menthol, lactic acid bacteria, glucomannan and purified water are mixed to prepare a herbal medicine mixture, dried and pulverized , herbal medicine powder manufacturing step (S30) of preparing the herbal medicine powder; and, mixing the herbal medicine concentrate prepared in the concentration step (S20) and the herbal medicine powder prepared in the herbal medicine powder preparation step (S30) to prepare granules, powders, or pills (S42) characterized by comprising: It provides a method for preparing a composition for improving a hangover.
본 발명의 제조방법에 따라 제조된 숙취 개선용 조성물은 다시마, 귤피, 칡꽃, 헛개나무, 대추, 구기자뿌리, 녹차어린잎, 사철쑥, 사인, 국화, 침향, 이소말토올리고당, D-l 멘톨, 유산균, 글루코만난 및 정제수를 혼합한 생약재혼합물을 포함하여 숙취 개선 효과를 갖는다.The composition for improving a hangover prepared according to the manufacturing method of the present invention is kelp, tangerine peel, arrowroot flower, horseradish tree, jujube, goji berry root, green tea young leaf, wormwood, sagebrush, chrysanthemum, aloes, isomaltooligosaccharide, D-l menthol, lactic acid bacteria, glucomannan And it has a hangover improvement effect, including a herbal medicine mixture mixed with purified water.
도 1은 본 발명에 따른 숙취 개선용 조성물의 제조공정을 나타낸 플로우차트다.
도 2는 실시예 1 및 비교예 1 내지 13의 조성물을 처리한 시험군의 시간별 알코올 함량을 나타낸 그래프.
도 3은 실시예 1 및 비교예 1 내지 13의 조성물을 처리한 시험군의 시간별 아세트알데히드 함량을 나타낸 그래프.
도 4는 실시예 1 및 비교예 1 내지 13의 조성물을 처리한 시험군의 시간별 알코올 탈수소효소 함량을 나타낸 그래프.
도 5 내지 도 7은 실시예 1 및 비교예 1 내지 13의 조성물을 처리한 시험군의 간기능 검사에 대한 그래프.1 is a flowchart showing the manufacturing process of a composition for improving hangover according to the present invention.
Figure 2 is a graph showing the alcohol content over time of the test group treated with the compositions of Example 1 and Comparative Examples 1 to 13.
Figure 3 is a graph showing the acetaldehyde content over time of the test group treated with the compositions of Example 1 and Comparative Examples 1 to 13.
Figure 4 is a graph showing the alcohol dehydrogenase content over time of the test group treated with the compositions of Example 1 and Comparative Examples 1 to 13.
5 to 7 are graphs of the liver function test of the test group treated with the compositions of Example 1 and Comparative Examples 1 to 13.
이하의 본 발명에 관한 상세한 설명들은 본 발명이 실시될 수 있는 실시 예이고 해당 실시 예의 예시로써 도시된 첨부 도면을 참조한다. 이들 실시 예는 당 업자가 본 발명의 실시에 충분하도록 상세히 설명된다. 본 발명의 다양한 실시 예는 서로 다르지만 상호 배타적일 필요는 없음이 이해되어야 한다. 예를 들어, 여기에 기재되어 있는 특정 형상, 구조 및 특성은 일 실시 예에 관련하여 본 발명의 사상 및 범위를 벗어나지 않으면서 다른 실시 예로 구현될 수 있다. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS The following detailed description of the present invention is an embodiment in which the present invention may be practiced, and reference is made to the accompanying drawings shown by way of example of the embodiment. These embodiments are described in sufficient detail to enable those skilled in the art to practice the present invention. It should be understood that various embodiments of the present invention are different but need not be mutually exclusive. For example, certain shapes, structures, and characteristics described herein may be implemented in other embodiments without departing from the spirit and scope of the invention in relation to one embodiment.
또한, 각각의 기재된 실시 예 내의 개별 구성요소의 위치 또는 배치는 본 발명의 사상 및 범위를 벗어나지 않으면서 변경될 수 있음이 이해되어야 한다.In addition, it should be understood that the position or arrangement of individual components in each described embodiment may be changed without departing from the spirit and scope of the present invention.
따라서 후술되는 상세한 설명은 한정적인 의미로서 취하려는 것이 아니며, 본 발명의 범위는 적절하게 설명된다면 그 청구항들이 주장하는 것과 균등한 모든 범위와 더불어 첨부된 청구항에 의해서만 한정된다. Accordingly, the detailed description set forth below is not intended to be taken in a limiting sense, and the scope of the present invention, if properly described, is limited only by the appended claims, along with all scopes equivalent to those claimed by the claims.
도면에서 유사한 참조부호는 여러 측면에 걸쳐서 동일하거나 유사한 기능을 지칭한다.Like reference numerals in the drawings refer to the same or similar functions throughout the various aspects.
본 발명에서 사용되는 용어는 본 발명에서의 기능을 고려하면서 가능한 현재 널리 사용되는 일반적인 용어들을 선택하였으나, 이는 당 분야에 종사하는 기술자의 의도 또는 판례, 새로운 기술의 출현 등에 따라 달라질 수 있다. 예를 들어, 김치유산균이라함은 락토바실러스플랜타럼 등의 김치로부터 얻어지는 유산균을 지칭하며, 이는 시중의 김치유산균 구입을 통해 얻을 수 있을 것이다.The terms used in the present invention have been selected as currently widely used general terms as possible while considering the functions in the present invention, but these may vary depending on the intention or precedent of a person skilled in the art, the emergence of new technology, and the like. For example, kimchi lactic acid bacteria refers to lactic acid bacteria obtained from kimchi such as Lactobacillus plantarum, which may be obtained through the purchase of kimchi lactic acid bacteria in the market.
또한, 특정한 경우는 출원인이 임의로 선정한 용어도 있으며, 이 경우 해당되는 발명의 설명 부분에서 상세히 그 의미를 기재할 것이다. In addition, in a specific case, there is a term arbitrarily selected by the applicant, and in this case, the meaning will be described in detail in the description of the corresponding invention.
따라서 본 발명에서 사용되는 용어는 단순한 용어의 명칭이 아닌, 그 용어가 가지는 의미와 본 발명의 전반에 걸친 내용을 토대로 정의되어야 한다.Therefore, the term used in the present invention should be defined based on the meaning of the term and the overall content of the present invention, rather than the name of a simple term.
본 발명에서 어떤 부분이 어떤 구성요소를 “포함”한다고 할 때, 이는 특별히 반대되는 기재가 없는 한, 다른 구성요소를 제외하는 것이 아니라 다른 구성요소를 더 포함할 수 있음을 의미한다.In the present invention, when a part “includes” a certain component, it means that other components may be further included, rather than excluding other components, unless otherwise stated.
이하, 본 발명에 따른 숙취 개선용 조성물 및 그 제조방법에 대하여 자세히 설명한다.Hereinafter, the composition for alleviating a hangover according to the present invention and a method for manufacturing the same will be described in detail.
본 발명은 다시마, 귤피, 칡꽃, 헛개나무, 대추, 구기자뿌리, 녹차어린잎, 사철쑥, 사인, 국화, 침향, 이소말토올리고당, D-l 멘톨, 유산균, 글루코만난 및 정제수를 혼합한 생약재혼합물을 포함하는 것을 특징으로 하는 숙취 개선용 조성물을 제공한다.The present invention relates to kelp, tangerine peel, arrowroot flower, kelp tree, jujube, goji root, green tea young leaf, wormwood, sage, chrysanthemum, aloes, isomaltooligosaccharide, D-1 menthol, lactic acid bacteria, glucomannan and a herbal medicine mixture containing purified water. It provides a composition for improving hangover, characterized in that.
상기 다시마(Saccharina japonica)는 갈조강 다시마목 다시마과의 한 속으로, 한국·일본·캄차카반도·사할린섬 등의 태평양 연안에서 자생한다. 다시마에는 카로틴류·크산토필류·엽록소 등의 여러 가지 색소 외에 탄소동화작용으로 만들어지는 마니트·라미나린 등의 탄수화물과 세포벽의 성분인 알긴산이 많이 들어 있고, 요오드·비타민 B2·글루탐산 등의 아미노산이 들어 있다.The kelp (Saccharina japonica) is a genus of kelp family, and grows wild in the Pacific coast of Korea, Japan, Kamchatka Peninsula, Sakhalin Island, and the like. In addition to various pigments such as carotene, xanthophylls, and chlorophyll, kelp contains a lot of carbohydrates such as mannite and laminarin produced by carbon assimilation, alginic acid, a component of the cell wall, and amino acids such as iodine, vitamin B2, and glutamic acid. contains this
상기 귤피는 운향과의 귤(Citrus unshiu Markovich) 또는 동속 근연식물의 성숙한 과피를 지칭하며, 진피[陳皮]라고도 한다. 일본에서는 귤(Citrus unshiu Markovich)과 병감(Citrus reticulata Blanco)을 진피로, 귤감(Citrus tachibana(Makino) Tanaka)을 귤피(橘皮)로 사용하고 있으며 중국에서는 병감(Citrus reticulata Blanco) 및 그 재배변종을 진피로 규정하고 있다.The tangerine peel refers to the mature pericarp of Citrus unshiu Markovich or a closely related plant of the family Unhyang, also called dermis [陳皮]. In Japan, mandarin orange (Citrus unshiu Markovich) and byeonggam (Citrus reticulata Blanco) are used as dermis, and citrus persimmon (Citrus tachibana(Makino) Tanaka) is used as mandarin peel (橘皮), and in China, byeonggam (Citrus reticulata Blanco) and its cultivars is defined as the dermis.
상기 칡꽃은 칡(Pueraria lobata (Willd.) Ohwi)의 꽃을 지칭한다. 상기 칡은 콩과(Leguminosae) 식물로 고지의 양지바르고 토질이 좋은 기슭이나 언덕에 주로 서식한다. 칡꽃은 여름에 채취하며, 갈화(葛花)라고도 한다. The arrowroot flower refers to the flower of the arrowroot (Pueraria lobata (Willd.) Ohwi). The arrowroot is a leguminosae plant, and it mainly inhabits at the foot of the highland with good soil or at the foot of the hill. Arrowroot flowers are collected in summer and are also called brown flowers.
상기 헛개나무(Hovenia dulcis Thunb.)는 갈매나무과(Rhamnaceae)의 식물로, 깊은 산이나 높은 산까지 50~800m 고지의 자갈이 많은 곳이나 계곡가 양지 쪽에 주로 서식한다. 상기 헛개나무는 뿌리(지구), 줄기껍질(지구목), 잎(지구엽)을 모두 사용할 수 있다.The Hovenia dulcis Thunb.) is a plant of the Rhamnaceae family, and mainly inhabits on the sunny side of the valley or in a place where there is a lot of gravel at a high altitude of 50 to 800 m to a deep mountain or a high mountain. The huotgae tree can use all of the roots (earth), stem bark (terrestrial tree), and leaves (earth leaf).
상기 대추(Ziziphus jujuba var. inermis)는 과실은 생식할 뿐 아니라 채취한 후 푹 말려 건과(乾果)로서 과자 ·요리 및 약용으로 쓰인다. 대추는 생활속에서 가공하여 대추술, 대추차, 대추식초, 대추죽 등으로도 활용한다. 가공품으로서의 꿀대추는 중국·일본·유럽에서도 호평을 받고 있다. 한방에서는 이뇨·강장(强壯)·완화제(緩和劑)로 쓰인다.The jujube (Ziziphus jujuba var. inermis) is not only raw, but also dried after being collected and used for confectionery, cooking, and medicine as a dried fruit. Jujubes are processed in daily life and used as jujube wine, jujube tea, jujube vinegar, and jujube porridge. Honey jujube as a processed product has been well received in China, Japan and Europe. In oriental medicine, it is used as a diuretic, tonic, and laxative.
상기 구기자뿌리는 구기자나무(Lycium chinense Miller) 또는 기타 동속식물의 뿌리를 지칭한다. 중국은 영하구기자(Lycium barbarum L.:寧夏拘杞子)를 사용하고 일본은 구기자나무(Lycium chinense Miller)및 영하구기자(Lycium barbarum L.:寧夏拘杞子)를 사용한다. 상기 구기자는 1월에 뿌리를 캐서 2월에 달여 먹는다.The root of Goji berry refers to the root of Lycium chinense Miller or other animals and plants. Lycium barbarum L.: 寧夏拘杞子 is used in China, and Lycium chinense Miller and Lycium barbarum L.:寧夏拘杞子 are used in Japan. The goji berries are digged up in January and eaten by the month of February.
상기 녹차어린잎은 차나무(Camellia sinensis O. Kuntze)의 어린잎을 지칭하며, 상기 차나무는 경남, 전남의 남해안지역의 비교적 따뜻한 곳에서 자라는 여러해살이 상록교목으로 높이 50~150cm이다. 잎은 단단하고 약간 두꺼우며 표면에 광택이 있다. 어린 눈과 잎은 녹차와 홍차를 만드는데 이용하며, 열매로는 기름을 짠다. 꽃은 10∼11월에 흰색 또는 연분홍색으로 피고 잎겨드랑이 또는 가지 끝에 1∼3개가 달린다.The green tea young leaf refers to the young leaves of a tea tree (Camellia sinensis O. Kuntze), and the tea tree is a perennial evergreen tree growing in a relatively warm place in the southern coastal region of Gyeongnam, Jeollanam-do and has a height of 50-150 cm. The leaves are hard, slightly thick, and have a glossy surface. The young eyes and leaves are used to make green and black tea, and the fruits are used to make oil. The flowers are white or light pink in October-November, and 1 to 3 flowers hang from the leaf axil or the tip of the branch.
상기 사철쑥(Artemisia capillaris Thunb.)은 국화과(Compositae)의 식물로, 전국의 하천 범람원과 하원, 냇가, 해안 등, 모래자갈땅에 서식한다. 상기 사철쑥은 여러해살이로 바로 서서 자라며, 밑부분은 목질화된다. 봄에 새로 난 어린잎은 전형적인 쑥 잎처럼 생겼으며, 백색 견모(絹毛)가 밀생하고, 꽃필 때에 말라 없어진다. 다 큰 잎은 2회우상(羽狀)으로 갈라지며 선형으로 봄에 난 어린잎과 모양이 완전히 다르다.The wormwood (Artemisia capillaris Thunb.) is a plant of the Compositae family, and inhabits river floodplains, rivers, streams, coasts, etc. across the country, on sandy gravel land. The wormwood is a perennial that grows upright, and the lower part is woody. New young leaves in spring look like typical mugwort leaves, white silky hairs are dense, and they dry out when flowering. The mature leaves are divided into two lobes, and the shape is completely different from that of the young leaves in spring.
상기 사인은 생강과 식물인 축사(Amomum xanthoides Wall.) 또는 양춘사 (A. villosum Lour.)의 여문 씨를 말린 것이다. 맛은 맵고 성질은 따뜻하다. 비경(脾經) · 위경(胃經) · 폐경(肺經) · 대장경(大腸經) · 소장경(小腸經) · 신경(腎經) · 방광경(膀胱經)에 작용한다.The cause is the dried seeds of the ginger plant, Amomum xanthoides Wall. or Yangchunsa (A. villosum Lour.). The taste is spicy and the nature is warm. It acts on the parenteral, gastric, menopause, large intestine, small intestine, nerve, and bladder.
상기 국화(Chrysanthemum morifolium)는 쌍떡잎식물 초롱꽃목 국화과의 여러해살이풀을 지칭한다. 국화는 관상용으로 널리 재배하며, 많은 원예 품종이 있다. 높이 1m 정도로 줄기 밑부분이 목질화하며, 잎은 어긋나고 깃꼴로 갈라진다. 꽃은 두상화로 줄기 끝에 피는데 가운데는 관상화, 주변부는 설상화다. 설상화는 암술만 가진 단성화이고 관상화는 암·수술을 모두 가진 양성화다.The chrysanthemum (Chrysanthemum morifolium) refers to the dicotyledonous perennial herbs of the order Asteraceae. Chrysanthemums are widely grown for ornamental purposes, and there are many horticultural varieties. It is about 1m high and the lower part of the stem becomes woody, and the leaves are alternate phyllotaxis and divided into pinnates. The flowers are capsicum, which bloom at the end of the stem, with a tubular flower in the middle and a snow flower in the periphery. Snow flower is a unisexual flower with only a pistil, and a tubular flower is a bisexual flower with both cancer and surgery.
상기 침향은 침향나무(Aquilaria agallocha Roxburgh(팥꽃나무과 Thymeleaceae))의 수지가 침착된 수간목이다. 침향은 침향나무에 천연적으로 분비된 수지가 침착하여 침향나무의 심재부위에 조직학적으로 단단한 덩어리 모양을 이루고 있는 부분이다. 침수향(沈水香)이라고도 한다.The aloes wood is a trunk tree in which the resin of Aquilaria agallocha Roxburgh (Thymeleaceae) is deposited. Alopecia is a part that forms a histologically hard mass in the heartwood of aloes wood due to the deposition of resin naturally secreted from the aloes tree. It is also called submerged incense (沈水香).
상기 이소말토올리고당은 다당류인 올리고당에 속한다. 이소말토올리고당은 쌀이나 옥수수 등의 녹말가루를 가공해 포도당을 연결하여 만든 것이다. 주로 쌀이나 옥수수 등의 녹말가루에서 얻는다. 과당이 없고 포도당만으로 구성돼 있어 과당이 포함된 프락토올리고당에 비해 단맛이 덜하다. 열에 강하기 때문에 조림, 볶음 등에 많이 쓰인다The isomaltooligosaccharide belongs to oligosaccharides, which are polysaccharides. Isomaltooligosaccharide is made by processing starch powder such as rice or corn and linking glucose. It is mainly obtained from starch powder such as rice or corn. Since it does not contain fructose and consists only of glucose, it is less sweet than fructooligosaccharide containing fructose. Because it is strong against heat, it is widely used for stewing and stir-frying.
상기 D-l 멘톨은 지방족 고급알코올류에 속하는 착향료로 음료, 아이스크림, 껌 등에 사용된다. 무색의 주상 또는 침상의 결정 또는 백색 결정성 분말로 특이하고 상쾌한 방향이 있으며 처음에 약간 쓴맛이 있고 다음에 청량한 맛이 나는 착향료이다. 화학식은 C10H20O 이다. 물에 잘 녹지 않으며, 유기용매와 염산에 녹는다. 승화성이 있으며 비선광성이다. 응고점 27∼28℃, 녹는점 32~38℃, 끓는점 103~105℃, 굴절률 n(20, D)은 1.4615이다.The D-1 menthol is used as a flavoring agent belonging to aliphatic higher alcohols, such as beverages, ice cream, and gum. It is a colorless columnar or needle-shaped crystal or white crystalline powder, with a peculiar and refreshing aroma, and is a flavoring agent that is slightly bitter at first and then has a refreshing taste. The chemical formula is C10H20O. Insoluble in water, soluble in organic solvents and hydrochloric acid. It is sublimable and non-rotating. The freezing point is 27-28 ℃, the melting point is 32-38 ℃, the boiling point is 103-105 ℃, the refractive index n(20, D) is 1.4615.
상기 유산균(lactic acid bacteria)은 발효에 의해 생장하는 세균 중 발효 결과 유산을 주된 산물로 생산하는 세균들을 의미한다. 당을 발효시켜 유산을 생성하는 간균. 그람 양성을 나타내며 포자(胞子)를 가지지 않는다. 유산간균과(Lacto-bacill-aceae)의 유산균속(Lacto-bacillus)에 속한다. 미호기성(微好氣性) 또는 혐기성이다. 유산균의 종류로는 유산균음료 제조에 유용한 아티도필스균, 모유영양아(母乳營養兒)의 장에 많이 서식하는 비피두스균, 불가리아유(乳)라 불리는 발효물을 만드는 불가리아균 등이 있다. 한편, 김치유산균을 사용할 수도 있다. 김치유산균은 시중에 판매중인 것을 구입하여 이용할 수 있다.The lactic acid bacteria refers to bacteria that produce lactic acid as a main product as a result of fermentation among bacteria grown by fermentation. Bacteria that ferment sugar to produce lactic acid. It is Gram-positive and has no spores. It belongs to the genus Lacto-bacillus of the family Lacto-bacill-aceae. It is microaerobic (微好气性) or anaerobic. The types of lactic acid bacteria include Artidophils, which is useful for the manufacture of lactic acid beverages, Bifidobacterium, which lives a lot in the intestines of breast-fed infants, and Bulgarian bacteria that makes a fermented product called Bulgarian milk. Meanwhile, kimchi lactic acid bacteria may be used. Kimchi lactic acid bacteria can be purchased and used commercially.
상기 글루코만난은 d-글루코스와 d-마노스를 주요 구성성분으로하는 다당류다. 주로 천남성과 곤약(Amorphophallus Konjq)의 뿌리줄기로부터 얻을 수 있다. 상기 글루코만난은 천남성과 구약나물(곤약, Amorphophalus konjac)을 이소프로필알코올로 추출하고 정제하여 다당류 분획을 얻은 후 식용에 적합하도록 한 것을 말하며 식이섬유를 69% 이상 함유하고 있어야 한다.The glucomannan is a polysaccharide mainly composed of d-glucose and d-mannose. It is mainly obtained from the rhizome of Amorphophallus Konjq. The glucomannan refers to a product suitable for edible use after extracting and purifying a polysaccharide fraction by extracting and purifying Chrysanthemum and Old Testament herbs (konjac, Amorphophalus konjac) with isopropyl alcohol, and should contain 69% or more of dietary fiber.
상기 정제수는 물에 함유되어 있는 용해된 이온, 고체입자, 미생물, 유기물 및 용해된 기체류 등 불순물을 제거한 물을 지칭한다.The purified water refers to water from which impurities such as dissolved ions, solid particles, microorganisms, organic matter, and dissolved gases contained in water are removed.
이때, 상기 다시마, 귤피, 칡꽃, 헛개나무, 대추, 구기자뿌리, 녹차어린잎, 사철쑥, 사인, 국화, 침향, 이소말토올리고당, D-l 멘톨, 유산균, 글루코만난 및 정제수는 각각 0.01 ~ 99.85중량%로 혼합되는 것이 적절하다.At this time, the kelp, tangerine peel, arrowroot flower, kelp tree, jujube, goji root, green tea young leaf, wormwood, sage, chrysanthemum, aloes, isomaltooligosaccharide, D-1 menthol, lactic acid bacteria, glucomannan and purified water are mixed in 0.01 to 99.85 wt%, respectively. it is appropriate to be
구체적으로, 본 발명에 따른 생약재혼합물은, 다시마 0.01 ~ 99.85중량%, 귤피 0.01 ~ 99.85중량%, 칡꽃 0.01 ~ 99.85중량%, 헛개나무 0.01 ~ 99.85중량%, 대추 0.01 ~ 99.85중량%, 구기자뿌리 0.01 ~ 99.85중량%, 녹차어린잎 0.01 ~ 99.85중량%, 사철쑥 0.01 ~ 99.85중량%, 사인 0.01 ~ 99.85중량%, 국화 0.01 ~ 99.85중량%, 침향 0.01 ~ 99.85중량%, 이소말토올리고당 0.01 ~ 99.85중량%, D-l 멘톨 0.01 ~ 99.85중량%, 유산균 0.01 ~ 99.85중량%, 글루코만난 0.01 ~ 99.85중량% 및 정제수 0.01 ~ 99.85중량%를 포함하는 것일 수 있다.Specifically, the herbal medicine mixture according to the present invention, kelp 0.01 ~ 99.85% by weight, tangerine peel 0.01 ~ 99.85% by weight, arrowroot 0.01 ~ 99.85% by weight, Heotgae tree 0.01 ~ 99.85% by weight, jujube 0.01 ~ 99.85% by weight, Goji root 0.01 ~ 99.85% by weight, green tea leaves 0.01 ~ 99.85% by weight, wormwood 0.01 ~ 99.85% by weight, coriander 0.01 ~ 99.85% by weight, chrysanthemum 0.01 ~ 99.85% by weight, aloes root 0.01 ~ 99.85% by weight, isomaltooligosaccharide 0.01 ~ 99.85% by weight , D-1 menthol 0.01 to 99.85% by weight, lactic acid bacteria 0.01 to 99.85% by weight, glucomannan 0.01 to 99.85% by weight and purified water 0.01 to 99.85% by weight.
한편, 본 발명에 따른 숙취 개선용 조성물은 상기 생약재혼합물을 각각 생약재농축액과 생약재분말로 제조하여 혼합한 것일 수 있다.On the other hand, the composition for improving hangover according to the present invention may be prepared by mixing the herbal medicine mixture with herbal medicine concentrate and herbal medicine powder, respectively.
이에, 본 발명에 따른 숙취 개선용 조성물은 다시마, 귤피, 칡꽃, 헛개나무, 대추, 구기자뿌리, 녹차어린잎, 사철쑥, 사인, 국화, 침향, 이소말토올리고당, D-l 멘톨, 유산균, 글루코만난 및 정제수를 혼합한 생약재혼합물을 추출하고, 농축한, 생약재농축액과; 다시마, 귤피, 칡꽃, 헛개나무, 대추, 구기자뿌리, 녹차어린잎, 사철쑥, 사인, 국화, 침향, 이소말토올리고당, D-l 멘톨, 유산균, 글루코만난 및 정제수를 혼합한 생약재혼합물을 건조하고 분쇄한 생약재 분말을 혼합한 것일 수 있다. 이때, 상기 생약재농축액과 생약재분말은 각각 0.1 ~ 99.9 : 0.1 ~ 99.9의 중량비로 혼합되는 것일 수 있다.Accordingly, the composition for improving a hangover according to the present invention contains kelp, tangerine peel, arrowroot flower, horseradish tree, jujube, goji berry root, green tea young leaf, wormwood, sage, chrysanthemum, aloes, isomaltooligosaccharide, D-1 menthol, lactic acid bacteria, glucomannan and purified water. Extracting and concentrating the mixed herbal medicine mixture, and herbal medicine concentrate; Herbal medicine powder by drying and pulverizing a herbal medicine mixture containing kelp, tangerine peel, arrowroot flower, horseradish tree, jujube, goji berry root, green tea young leaf, wormwood, sage, chrysanthemum, aloes, isomaltooligosaccharide, D-l menthol, lactic acid bacteria, glucomannan and purified water. may be a mixture of In this case, the herbal medicine concentrate and the herbal medicine powder may be mixed in a weight ratio of 0.1 to 99.9: 0.1 to 99.9, respectively.
또한, 본 발명은 숙취 개선용 조성물의 제조방법을 제공한다.In addition, the present invention provides a method for preparing a composition for improving hangover.
본 발명에 따른 숙취 개선용 조성물의 제조방법은 다시마, 귤피, 칡꽃, 헛개나무, 대추, 구기자뿌리, 녹차어린잎, 사철쑥, 사인, 국화, 침향, 이소말토올리고당, D-l 멘톨, 유산균, 글루코만난 및 정제수를 혼합하여 생약재혼합물을 제조하고, 생약재혼합물로부터 생약재추출물을 추출하는 추출 단계(S10); 상기 추출 단계(S10)에서 추출된 생약재추출물을 농축하여, 생약재농축액을 제조하는 농축 단계(S20); 다시마, 귤피, 칡꽃, 헛개나무, 대추, 구기자뿌리, 녹차어린잎, 사철쑥, 사인, 국화, 침향, 이소말토올리고당, D-l 멘톨, 유산균, 글루코만난 및 정제수를 혼합하여 생약재혼합물을 제조하고, 건조 분쇄하여, 생약재분말을 제조하는 생약재분말 제조 단계(S30); 및, 상기 농축 단계(S20)에서 제조된 생약재농축액과 상기 생약재분말 제조 단계(S30)에서 제조된 생약제 분말을 혼합하여 시럽을 제조하는 시럽 제조단계(S41)를 포함한다.The preparation method of the composition for improving hangover according to the present invention is kelp, tangerine peel, arrowroot flower, kohlrabi, jujube, goji berry root, green tea young leaf, wormwood, sage, chrysanthemum, aloes, isomaltooligosaccharide, D-l menthol, lactic acid bacteria, glucomannan and purified water. An extraction step (S10) of preparing a herbal medicine mixture by mixing and extracting a herbal medicine extract from the herbal medicine mixture; Concentrating the herbal medicine extract extracted in the extraction step (S10) to prepare a herbal medicine concentrate (S20); Kelp, tangerine peel, arrowroot flower, honeysuckle, jujube, goji root, green tea young leaf, wormwood, sage, chrysanthemum, aloes, isomaltooligosaccharide, D-l menthol, lactic acid bacteria, glucomannan and purified water are mixed to prepare a herbal medicine mixture, dried and pulverized , herbal medicine powder manufacturing step (S30) of preparing the herbal medicine powder; and a syrup preparation step (S41) of preparing a syrup by mixing the herbal medicine concentrate prepared in the concentration step (S20) and the herbal medicine powder prepared in the herbal medicine powder preparation step (S30).
우선, 추출 단계(S10)를 수행한다.First, the extraction step (S10) is performed.
상기 추출 단계(S10)에서는 다시마, 귤피, 칡꽃, 헛개나무, 대추, 구기자뿌리, 녹차어린잎, 사철쑥, 사인, 국화, 침향, 이소말토올리고당, D-l 멘톨, 유산균, 글루코만난 및 정제수를 혼합하여 생약재혼합물을 제조하고, 생약재혼합물로부터 생약재추출물을 추출한다.In the extraction step (S10), kelp, tangerine peel, arrowroot flower, horseradish tree, jujube, goji berry root, green tea young leaf, wormwood, sage, chrysanthemum, aloes, isomaltooligosaccharide, D-1 menthol, lactic acid bacteria, glucomannan and purified water are mixed to obtain a herbal medicine mixture. and extract the herbal extract from the herbal mixture.
상기 추출 단계(S10)에서의 생약재혼합물은 상기 다시마, 귤피, 칡꽃, 헛개나무, 대추, 구기자뿌리, 녹차어린잎, 사철쑥, 사인, 국화, 침향, 이소말토올리고당, D-l 멘톨, 유산균, 글루코만난 및 정제수가 각각 0.01 ~ 99.84중량%로 혼합된 것이 바람직하다.The herbal medicine mixture in the extraction step (S10) is the kelp, tangerine peel, arrowroot flower, hemp, jujube, goji berry root, green tea young leaf, wormwood, sagebrush, chrysanthemum, aloes, isomaltooligosaccharide, D-1 menthol, lactic acid bacteria, glucomannan and purified water. It is preferable that each is mixed in an amount of 0.01 to 99.84% by weight.
상기 추출 단계(S10)에서의 생약재혼합물은, 다시마 0.01 ~ 99.85중량%, 귤피 0.01 ~ 99.85중량%, 칡꽃 0.01 ~ 99.85중량%, 헛개나무 0.01 ~ 99.85중량%, 대추 0.01 ~ 99.85중량%, 구기자뿌리 0.01 ~ 99.85중량%, 녹차어린잎 0.01 ~ 99.85중량%, 사철쑥 0.01 ~ 99.85중량%, 사인 0.01 ~ 99.85중량%, 국화 0.01 ~ 99.85중량%, 침향 0.01 ~ 99.85중량%, 이소말토올리고당 0.01 ~ 99.85중량%, D-l 멘톨 0.01 ~ 99.85중량%, 유산균 0.01 ~ 99.85중량%, 글루코만난 0.01 ~ 99.85중량% 및 정제수 0.01 ~ 99.85중량%를 혼합한 것이 바람직하다.The herbal medicine mixture in the extraction step (S10) is 0.01 ~ 99.85% by weight of kelp, 0.01 ~ 99.85% by weight of tangerine peel, 0.01 ~ 99.85% by weight of arrowroot flower, 0.01 ~ 99.85% by weight of Heotgae tree, 0.01 ~ 99.85% by weight of jujube, Goji root 0.01 ~ 99.85% by weight, green tea leaves 0.01 ~ 99.85% by weight, wormwood 0.01 ~ 99.85% by weight, sage 0.01 ~ 99.85% by weight, chrysanthemum 0.01 ~ 99.85% by weight, aloes root 0.01 ~ 99.85% by weight, isomaltooligosaccharide 0.01 ~ 99.85% by weight %, 0.01 to 99.85% by weight of menthol D-1, 0.01 to 99.85% by weight of lactic acid bacteria, 0.01 to 99.85% by weight of glucomannan, and 0.01 to 99.85% by weight of purified water are preferably mixed.
보다 구체적으로, 상기 추출 단계(S10)에서의 생약재혼합물은, 다시마 6.0 ~ 10.0중량%, 귤피 6.0 ~ 10.0중량%, 칡꽃 6.0 ~ 10.0중량%, 헛개나무 6.0 ~ 10.0중량%, 대추 6.0 ~ 10.0중량%, 구기자뿌리 6.0 ~ 10.0중량%, 녹차어린잎 6.0 ~ 10.0중량%, 사철쑥 6.0 ~ 10.0중량%, 사인 6.0 ~ 10.0중량%, 국화 6.0 ~ 10.0중량%, 침향 6.0 ~ 10.0중량%, 이소말토올리고당 6.0 ~ 10.0중량%, D-l 멘톨 6.0 ~ 10.0중량%, 유산균 6.0 ~ 10.0중량%, 글루코만난 6.0 ~ 10.0중량% 및 정제수 6.0 ~ 10.0중량%를 혼합한 것이 바람직하다.More specifically, the herbal medicine mixture in the extraction step (S10) is 6.0 to 10.0% by weight of kelp, 6.0 to 10.0% by weight of tangerine peel, 6.0 to 10.0% by weight of arrowroot flower, 6.0 to 10.0% by weight of Heotgae tree, 6.0 to 10.0% by weight of jujube %, Goji root 6.0 ~ 10.0% by weight, Green tea leaves 6.0 ~ 10.0% by weight, Artemisia wormwood 6.0 ~ 10.0% by weight, Sine 6.0 ~ 10.0% by weight, Chrysanthemum 6.0 ~ 10.0% by weight, Aloes root 6.0 ~ 10.0% by weight, Isomaltooligosaccharide 6.0 to 10.0% by weight, 6.0 to 10.0% by weight of D-1 menthol, 6.0 to 10.0% by weight of lactic acid bacteria, 6.0 to 10.0% by weight of glucomannan, and 6.0 to 10.0% by weight of purified water are preferably mixed.
상기 추출 단계(S10)에서는 생약재혼합물을 1,500 내지 3,000 mL의 추출 용매에 넣고, 70 내지 85℃의 온도로 5 내지 10시간 동안 진공상태에서 생약재 추출물을 추출하는것이 바람직하다.In the extraction step (S10), it is preferable to put the herbal medicine mixture into an extraction solvent of 1,500 to 3,000 mL, and extract the herbal extract in a vacuum at a temperature of 70 to 85° C. for 5 to 10 hours.
상기 추출 단계(S10)에서의 추출용매는 정제수와 식품용 알코올을 2 : 8 내지 4 : 6 중량비로 혼합한 추출 용매를 이용한다. 상기 식품용 알코올은 에탄올인 것이 바람직하다. 상기 추출 용매는 알코올 대비 정제수의 중량비가 2 중량비 미만이면, 알코올 성분이 상대적으로 늘어나, 추출 후 남은 알코올을 제거하기 위한 공정이 추가되며, 알코올 대비 정제수의 중량비가 4 중량비 초과이면, 알코올 성분이 상대적으로 줄어 각각의 생약재에서 추출물들이 균일하게 추출되지 않는 문제점이 있다.As the extraction solvent in the extraction step (S10), an extraction solvent obtained by mixing purified water and food alcohol in a weight ratio of 2:8 to 4:6 is used. The food alcohol is preferably ethanol. In the extraction solvent, when the weight ratio of purified water to alcohol is less than 2 weight ratio, the alcohol component is relatively increased, a process for removing the alcohol remaining after extraction is added, and when the weight ratio of alcohol to purified water exceeds 4 weight ratio, the alcohol component is relatively There is a problem in that extracts are not uniformly extracted from each herbal medicine.
다음으로, 농축 단계(S20)를 수행한다.Next, a concentration step (S20) is performed.
상기 농축 단계(S20)에서는 상기 추출 단계(S10)에서 추출된 생약재추출물을 농축하여, 생약재농축액을 제조한다.In the concentration step (S20), the herbal medicine extract extracted in the extraction step (S10) is concentrated to prepare a herbal medicine concentrate.
상기 농축 단계(S20)에서는 3,000 내지 6,000 mL의 생약재추출물을 진공 저온 농축 방법으로 600 내지 1,200 mL의 생약재 농축액을 제조한다. 상기 진공 저온 농축 방법은 열 또는 공기에 영향을 받아 산화되기 쉬운 물질을 농축하는 방법으로, 진공상태에서 저온 40 내지 80℃에서 한다.In the concentration step (S20), 3,000 to 6,000 mL of herbal medicine extract is prepared by vacuum low temperature concentration method to prepare 600 to 1,200 mL of herbal medicine concentrate. The vacuum low temperature concentration method is a method of concentrating a material that is easily oxidized under the influence of heat or air, and is performed at a low temperature of 40 to 80° C. in a vacuum state.
다음으로, 생약재분말 제조 단계(S30)를 수행한다.Next, the herbal medicine powder manufacturing step (S30) is performed.
상기 생약재분말 제조 단계(S30)에서는 다시마, 귤피, 칡꽃, 헛개나무, 대추, 구기자뿌리, 녹차어린잎, 사철쑥, 사인, 국화, 침향, 이소말토올리고당, D-l 멘톨, 유산균, 글루코만난 및 정제수를 혼합하여 생약재혼합물을 제조하고, 건조 분쇄하여, 생약재분말을 제조한다.In the herbal medicine powder manufacturing step (S30), kelp, tangerine peel, arrowroot flower, horseradish tree, jujube, goji berry root, green tea young leaf, wormwood, sage, chrysanthemum, aloes, isomaltooligosaccharide, D-1 menthol, lactic acid bacteria, glucomannan and purified water are mixed. A herbal medicine mixture is prepared and dried and pulverized to prepare a herbal medicine powder.
상기 생약재분말 제조 단계(S30)에서의 생약재혼합물은, 다시마 0.01 ~ 99.85중량%, 귤피 0.01 ~ 99.85중량%, 칡꽃 0.01 ~ 99.85중량%, 헛개나무 0.01 ~ 99.85중량%, 대추 0.01 ~ 99.85중량%, 구기자뿌리 0.01 ~ 99.85중량%, 녹차어린잎 0.01 ~ 99.85중량%, 사철쑥 0.01 ~ 99.85중량%, 사인 0.01 ~ 99.85중량%, 국화 0.01 ~ 99.85중량%, 침향 0.01 ~ 99.85중량%, 이소말토올리고당 0.01 ~ 99.85중량%, D-l 멘톨 0.01 ~ 99.85중량%, 유산균 0.01 ~ 99.85중량%, 글루코만난 0.01 ~ 99.85중량% 및 정제수 0.01 ~ 99.85중량%를 혼합한 것이 바람직하다.The herbal medicine mixture in the herbal medicine powder manufacturing step (S30) is 0.01 ~ 99.85% by weight of kelp, 0.01 ~ 99.85% by weight of tangerine peel, 0.01 ~ 99.85% by weight of arrowroot flower, 0.01 ~ 99.85% by weight of Heotgae tree, 0.01 ~ 99.85% by weight of jujube, Goji root 0.01 ~ 99.85% by weight, green tea young leaves 0.01 ~ 99.85% by weight, wormwood 0.01 ~ 99.85% by weight, coriander 0.01 ~ 99.85% by weight, chrysanthemum 0.01 ~ 99.85% by weight, aloes root 0.01 ~ 99.85% by weight, isomaltooligosaccharide 0.01 ~ It is preferable to mix 99.85% by weight, 0.01 to 99.85% by weight of D-1 menthol, 0.01 to 99.85% by weight of lactic acid bacteria, 0.01 to 99.85% by weight of glucomannan, and 0.01 to 99.85% by weight of purified water.
보다 구체적으로, 상기 생약재분말 제조 단계(S30)에서의 생약재혼합물은, 다시마 6.0 ~ 10.0중량%, 귤피 6.0 ~ 10.0중량%, 칡꽃 6.0 ~ 10.0중량%, 헛개나무 6.0 ~ 10.0중량%, 대추 6.0 ~ 10.0중량%, 구기자뿌리 6.0 ~ 10.0중량%, 녹차어린잎 6.0 ~ 10.0중량%, 사철쑥 6.0 ~ 10.0중량%, 사인 6.0 ~ 10.0중량%, 국화 6.0 ~ 10.0중량%, 침향 6.0 ~ 10.0중량%, 이소말토올리고당 6.0 ~ 10.0중량%, D-l 멘톨 6.0 ~ 10.0중량%, 유산균 6.0 ~ 10.0중량%, 글루코만난 6.0 ~ 10.0중량% 및 정제수 6.0 ~ 10.0중량%를 혼합한 것이 적절하다.More specifically, the herbal medicine mixture in the herbal powder manufacturing step (S30) is 6.0 to 10.0% by weight of kelp, 6.0 to 10.0% by weight of tangerine peel, 6.0 to 10.0% by weight of arrowroot flower, 6.0 to 10.0% by weight of Heotgae tree, 6.0 to 10.0% by weight of jujube. 10.0% by weight, Goji root 6.0 to 10.0% by weight, green tea young leaves 6.0 to 10.0% by weight, wormwood 6.0 to 10.0% by weight, coriander 6.0 to 10.0% by weight, chrysanthemum 6.0 to 10.0% by weight, aloesaceae 6.0 to 10.0% by weight, iso It is appropriate to mix 6.0 to 10.0% by weight of maltooligosaccharide, 6.0 to 10.0% by weight of D-1 menthol, 6.0 to 10.0% by weight of lactic acid bacteria, 6.0 to 10.0% by weight of glucomannan, and 6.0 to 10.0% by weight of purified water.
상기 생약재분말 제조 단계(S30)에서는 상기 생약재 혼합물을 세척하여 배합한 후, 건조기에서 50 내지 65℃의 온도, 10 내지 12시간 동안 건조한 후, 80 내지 150 mesh의 생약재분말을 제조한다.In the herbal medicine powder manufacturing step (S30), the herbal medicine mixture is washed and blended, dried at a temperature of 50 to 65° C. in a dryer for 10 to 12 hours, and then the herbal medicine powder of 80 to 150 mesh is prepared.
다음으로, 시럽 제조단계(S41)를 수행한다.Next, the syrup preparation step (S41) is performed.
상기 시럽 제조단계(S41)에서는 상기 농축 단계(S20)에서 제조된 생약재농축액과 상기 생약재분말 제조 단계(S30)에서 제조된 생약제 분말을 혼합하여 시럽을 제조한다.In the syrup preparation step (S41), the herbal medicine concentrate prepared in the concentration step (S20) and the herbal medicine powder prepared in the herbal medicine powder preparation step (S30) are mixed to prepare a syrup.
이때, 상기 시럽 제조 단계(S41)에서 상기 생약재농축액과 생약재분말은 각각 0.1 ~ 99.9 : 1의 중량비로 혼합되는 것일 수 있다. 보다 구체적으로, 상기 시럽 제조 단계(S41)에서 상기 생약재농축액과 생약재분말은 4 : 1 ~ 20 : 1의 중량비로 혼합될 수 있을 것이다.In this case, in the syrup preparation step (S41), the herbal medicine concentrate and the herbal medicine powder may be mixed in a weight ratio of 0.1 to 99.9:1, respectively. More specifically, in the syrup preparation step (S41), the herbal medicine concentrate and the herbal medicine powder may be mixed in a weight ratio of 4:1 to 20:1.
또는, 본 발명에 따른 숙취 개선용 조성물의 제조방법은 시럽 제조단계(S41) 대신 약제 제조단계(S42)를 수행할 수도 있을 것이다. 상기 시럽 제조단계(S41)와 약제 제조단계(S42)는 생약재농축액과 생약재분말의 혼합 중량비를 달리한 것으로, 생약재농축액의 함량이 상대적으로 높으면 시럽이되며, 생약재분말의 함량이 상대적으로 높으면 과립제, 산제 또는, 환제가 될 수 있다.Alternatively, in the method for preparing the composition for improving hangover according to the present invention, the drug preparation step (S42) may be performed instead of the syrup preparation step (S41). The syrup manufacturing step (S41) and the drug manufacturing step (S42) have different mixing weight ratios of the herbal medicine concentrate and the herbal medicine powder, and when the content of the herbal medicine concentrate is relatively high, it becomes a syrup, and when the content of the herbal medicine powder is relatively high, it becomes a granule; It may be a powder or a pill.
상기 약제 제조단계(S42)에서는 상기 생약재농축액과 생약재분말을 1 : 1 내지 3 : 1 중량비로 배합한 후 동결 건조로 과립제를 제조한다. 상기 생약재농축액이 생약재분말 대비 1 중량비 미만이면 생약재분말의 중량비가 상대적으로 높아 생약재농축액의 숙취 개선 효과가 나타나지 않으며, 생약재분말 대비 3 중량비 초과이면 생약재 농축액과 생약재분말이 뭉쳐지지 않는다.In the pharmaceutical preparation step (S42), the herbal medicine concentrate and the herbal medicine powder are mixed in a weight ratio of 1:1 to 3:1 and then freeze-drying to prepare granules. If the herbal medicine concentrate is less than 1 weight ratio compared to the herbal medicine powder, the weight ratio of the herbal medicine powder is relatively high, so the hangover improvement effect of the herbal medicine concentrate does not appear.
상기 약제 제조단계(S42)에서는 생약재농축액과 생약재분말을 1 : 1 내지 3 : 1 중량비로 혼합하여 50 내지 65 ℃의 온도로 10 내지 12시간 동안 건조한 후, 80 내지 150 mesh의 산제를 제조한다.In the pharmaceutical preparation step (S42), the herbal medicine concentrate and the herbal medicine powder are mixed in a weight ratio of 1:1 to 3: 1, dried at a temperature of 50 to 65° C. for 10 to 12 hours, and then a powder of 80 to 150 mesh is prepared.
상기 약제 제조단계(S42)에서는 상기 산제 100 내지 300g에 찹쌀 50 내지 400g과 정제수 200 내지 800mL를 혼합하여 3 내지 5 mm의 직경으로 환제를 제조할 수도 있다.In the pharmaceutical preparation step (S42), 50 to 400 g of glutinous rice and 200 to 800 mL of purified water are mixed with 100 to 300 g of the powder to prepare a pill having a diameter of 3 to 5 mm.
이때, 숙취 개선용 조성물의 제조방법은 다시마, 귤피, 칡꽃, 헛개나무, 대추, 구기자뿌리, 녹차어린잎, 사철쑥, 사인, 국화, 침향, 이소말토올리고당, D-l 멘톨, 유산균, 글루코만난 및 정제수를 혼합하여 생약재혼합물을 제조하고, 생약재혼합물로부터 생약재추출물을 추출하는 추출 단계(S10); 상기 추출 단계(S10)에서 추출된 생약재추출물을 농축하여, 생약재농축액을 제조하는 농축 단계(S20); 다시마, 귤피, 칡꽃, 헛개나무, 대추, 구기자뿌리, 녹차어린잎, 사철쑥, 사인, 국화, 침향, 이소말토올리고당, D-l 멘톨, 유산균, 글루코만난 및 정제수를 혼합하여 생약재혼합물을 제조하고, 건조 분쇄하여, 생약재분말을 제조하는 생약재분말 제조 단계(S30); 및, 상기 농축 단계(S20)에서 제조된 생약재농축액과 상기 생약재분말 제조 단계(S30)에서 제조된 생약제 분말을 혼합하여 과립제, 산제 또는, 환제로 제조하는 약제 제조단계(S42)를 포함할 수 있다.At this time, the preparation method of the composition for improving hangover is a mixture of kelp, tangerine peel, arrowroot flower, horseradish tree, jujube, goji root, green tea young leaf, wormwood, sage, chrysanthemum, aloes, isomaltooligosaccharide, D-l menthol, lactic acid bacteria, glucomannan and purified water. an extraction step (S10) of preparing a herbal medicine mixture and extracting a herbal medicine extract from the herbal medicine mixture; Concentrating the herbal medicine extract extracted in the extraction step (S10) to prepare a herbal medicine concentrate (S20); Kelp, tangerine peel, arrowroot flower, honeysuckle, jujube, goji root, green tea young leaf, wormwood, sage, chrysanthemum, aloes, isomaltooligosaccharide, D-l menthol, lactic acid bacteria, glucomannan and purified water are mixed to prepare a herbal medicine mixture, dried and pulverized , herbal medicine powder manufacturing step (S30) of preparing the herbal medicine powder; And, mixing the herbal medicine concentrate prepared in the concentration step (S20) and the herbal medicine powder prepared in the herbal medicine powder preparation step (S30) to prepare granules, powders, or pills (S42) may include. .
상기, 추출 단계(S10), 농축 단계(S20), 생약재분말 제조 단계(S30)과, 시럽제조단계(S41) 또는 약제 제조단계(S42)를 수행하고 나면 본 발명에 따른 숙취 개선용 조성물을 얻을 수 있을 것이다.After performing the extraction step (S10), the concentration step (S20), the herbal medicine powder production step (S30), and the syrup production step (S41) or the drug production step (S42), a composition for improving a hangover according to the present invention is obtained will be able
이하, 하기 실시예 비교예 및 실험예를 통하여 본 발명에 따른 숙취 해소용 조성물이 갖는 효과에 대하여 자세히 확인한다.Hereinafter, the effect of the composition for relieving a hangover according to the present invention will be confirmed in detail through the following Comparative Examples and Experimental Examples.
실시예Example 1. 숙취 해소용 조성물의 제조 1. Preparation of a composition for relieving hangover
다시마, 귤피, 칡꽃, 헛개나무, 대추, 구기자뿌리, 녹차어린잎, 사철쑥, 사인, 국화, 침향, 이소말토올리고당, D-l 멘톨, 유산균, 글루코만난 및 정제수를 이용하여 실시예 1의 조성물을 제조하였다.The composition of Example 1 was prepared using kelp, tangerine peel, arrowroot flower, horseradish tree, jujube, goji root, green tea young leaf, wormwood, sage, chrysanthemum, aloes, isomaltooligosaccharide, D-1 menthol, lactic acid bacteria, glucomannan and purified water.
추출단계(S10): 다시마 6.25중량%, 귤피 6.25중량%, 칡꽃 6.25중량%, 헛개나무 6.25중량%, 대추 6.25중량%, 구기자뿌리 6.25중량%, 녹차어린잎 6.25중량%, 사철쑥 6.25중량%, 사인 6.25중량%, 국화 6.25중량%, 침향 6.25중량%, 이소말토올리고당 6.25중량%, D-l 멘톨 6.25중량%, 유산균 6.25중량%, 글루코만난 6.25중량% 및 정제수 6.25중량%를 혼합한 생약재혼합물에, 정제수와 에탄올을 3 : 7 중량비로 혼합한 추출용매 2,000 mL를 가하고, 70 내지 75℃의 온도로 10시간 동안 진공상태에서 추출하여 생약재 추출물을 제조하였다.Extraction step (S10): kelp 6.25% by weight, tangerine peel 6.25% by weight, arrowroot 6.25% by weight, Heotgae tree 6.25% by weight, jujube 6.25% by weight, goji root 6.25% by weight, green tea young leaves 6.25% by weight, mugwort 6.25% by weight, Sine 6.25% by weight, chrysanthemum 6.25% by weight, amethyst 6.25% by weight, isomaltooligosaccharide 6.25% by weight, D-1 menthol 6.25% by weight, lactic acid bacteria 6.25% by weight, glucomannan 6.25% by weight and purified water 6.25% by weight in a herbal medicine mixture mixed with purified water And 2,000 mL of an extraction solvent mixed with ethanol in a 3:7 weight ratio was added, and extracted in a vacuum at a temperature of 70 to 75° C. for 10 hours to prepare a herbal extract.
농축 단계(S20): 상기 추출단계(S10)에서 얻은 생약재추출물 4000mL를 진공 저온 농축 방법으로 800mL로 농축하여 생약재 농축액을 제조하였다.Concentration step (S20): 4000 mL of the herbal extract obtained in the extraction step (S10) was concentrated to 800 mL by vacuum low temperature concentration to prepare a herbal concentrate.
생약재분말 제조 단계(S30): 다시마 6.25중량%, 귤피 6.25중량%, 칡꽃 6.25중량%, 헛개나무 6.25중량%, 대추 6.25중량%, 구기자뿌리 6.25중량%, 녹차어린잎 6.25중량%, 사철쑥 6.25중량%, 사인 6.25중량%, 국화 6.25중량%, 침향 6.25중량%, 이소말토올리고당 6.25중량%, D-l 멘톨 6.25중량%, 유산균 6.25중량%, 글루코만난 6.25중량% 및 정제수 6.25중량%를 혼합한 생약재혼합물을, 건조기에서 60 내지 65℃의 온도로 10시간 동안 건조하고, 분쇄하여 100 mesh의 생약재 분말을 제조하였다.Herbal medicine powder manufacturing step (S30): kelp 6.25% by weight, tangerine peel 6.25% by weight, arrowroot 6.25% by weight, Heotgae tree 6.25% by weight, jujube 6.25% by weight, goji root 6.25% by weight, green tea young leaves 6.25% by weight, mugwort 6.25% by weight %, sine 6.25% by weight, chrysanthemum 6.25% by weight, amethyst 6.25% by weight, isomaltooligosaccharide 6.25% by weight, D-1 menthol 6.25% by weight, lactic acid bacteria 6.25% by weight, glucomannan 6.25% by weight and purified water 6.25% by weight , dried for 10 hours at a temperature of 60 to 65 ℃ in a dryer, and pulverized to prepare 100 mesh herbal medicine powder.
시럽 제조 단계(S41): 농축 단계(S20)에서 제조된 생약재농축액과 생약재분말 제조 단계(S30)에서 제조된 생약재분말을 4 : 1의 중량비로 혼합하여 시럽제를 제조하였다.Syrup preparation step (S41): The herbal medicine concentrate prepared in the concentration step (S20) and the herbal medicine powder prepared in the herbal medicine powder preparation step (S30) were mixed in a weight ratio of 4:1 to prepare a syrup.
비교예comparative example 1 내지 11. 단독 성분만 포함된 조성물의 제조 1 to 11. Preparation of a composition containing only a single component
실시예 1과 동일한 과정을 수행하되, 추출단계(S10) 및 생약재분말 제조 단계(S30)에서, 생약재 혼합물 대신에, 각각 다시마 100중량%(비교예1), 귤피 100중량%(비교예2), 칡꽃 100중량%(비교예3), 헛개나무 100중량%(비교예4), 대추 100중량%(비교예5), 구기자뿌리 100중량%(비교예6), 녹차어린잎 100중량%(비교예7), 사철쑥 100중량%(비교예8), 사인 100중량%(비교예9), 국화 100중량%(비교예10), 침향 100중량%(비교예11)로 수행하여, 비교예 1 내지 11의 단독 성분만 포함된 조성물을 제조하였다.Perform the same process as in Example 1, but in the extraction step (S10) and the herbal medicine powder manufacturing step (S30), instead of the herbal mixture, 100% by weight of kelp (Comparative Example 1), 100% by weight of tangerine peel (Comparative Example 2) ,
비교예comparative example 12. 12. 일부성분이some ingredients 배제된 조성물의 제조 Preparation of excluded compositions
실시예 1에 대하여, 다시마, 귤피, 칡꽃을 배제하고 비교예 12의 조성물을 제조해보았다.With respect to Example 1, the composition of Comparative Example 12 was prepared by excluding kelp, tangerine peel, and arrowroot flower.
추출단계(S10): 헛개나무 6.25중량%, 대추 6.25중량%, 구기자뿌리 6.25중량%, 녹차어린잎 6.25중량%, 사철쑥 6.25중량%, 사인 6.25중량%, 국화 6.25중량%, 침향 6.25중량%, 이소말토올리고당 6.25중량%, D-l 멘톨 6.25중량%, 유산균 6.25중량%, 글루코만난 6.25중량% 및 정제수 25.0중량%를 혼합한 생약재혼합물에, 정제수와 에탄올을 3 : 7 중량비로 혼합한 추출용매 2,000 mL를 가하고, 70 내지 75℃의 온도로 10시간 동안 진공상태에서 추출하여 생약재 추출물을 제조하였다.Extraction step (S10): Heotgae tree 6.25% by weight, jujube 6.25% by weight, goji root 6.25% by weight, green tea young leaves 6.25% by weight, wormwood 6.25% by weight, sine 6.25% by weight, chrysanthemum 6.25% by weight, aloes flower 6.25% by weight, In a herbal medicine mixture mixed with isomaltooligosaccharide 6.25% by weight, D-1 menthol 6.25% by weight, lactic acid bacteria 6.25% by weight, glucomannan 6.25% by weight, and purified water 25.0% by weight, 2,000 mL of an extraction solvent obtained by mixing purified water and ethanol in a 3: 7 weight ratio was added. was added, and extracted in a vacuum at a temperature of 70 to 75° C. for 10 hours to prepare a herbal extract.
농축 단계(S20): 상기 추출단계(S10)에서 얻은 생약재추출물 4000mL를 진공 저온 농축 방법으로 800mL로 농축하여 생약재 농축액을 제조하였다.Concentration step (S20): 4000 mL of the herbal extract obtained in the extraction step (S10) was concentrated to 800 mL by vacuum low temperature concentration to prepare a herbal concentrate.
생약재분말 제조 단계(S30): 헛개나무 6.25중량%, 대추 6.25중량%, 구기자뿌리 6.25중량%, 녹차어린잎 6.25중량%, 사철쑥 6.25중량%, 사인 6.25중량%, 국화 6.25중량%, 침향 6.25중량%, 이소말토올리고당 6.25중량%, D-l 멘톨 6.25중량%, 유산균 6.25중량%, 글루코만난 6.25중량% 및 정제수 6.25중량%를 혼합한 생약재혼합물을, 건조기에서 60 내지 65℃의 온도로 10시간 동안 건조하고, 분쇄하여 100 mesh의 생약재 분말을 제조하였다.Herbal medicine powder manufacturing step (S30): Heotgae tree 6.25% by weight, jujube 6.25% by weight, Goji root 6.25% by weight, green tea young leaves 6.25% by weight, wormwood 6.25% by weight, sine 6.25% by weight, chrysanthemum 6.25% by weight, aloes flower 6.25% by weight %, isomaltooligosaccharide 6.25% by weight, D-1 menthol 6.25% by weight, lactic acid bacteria 6.25% by weight, glucomannan 6.25% by weight, and purified water 6.25% by weight of the herbal medicine mixture, dried in a dryer at a temperature of 60 to 65 ℃ for 10 hours, and , to prepare 100 mesh herbal medicine powder.
시럽 제조 단계(S41): 농축 단계(S20)에서 제조된 생약재농축액과 생약재분말 제조 단계(S30)에서 제조된 생약재분말을 4 : 1의 중량비로 혼합하여 시럽제를 제조하였다.Syrup preparation step (S41): The herbal medicine concentrate prepared in the concentration step (S20) and the herbal medicine powder prepared in the herbal medicine powder preparation step (S30) were mixed in a weight ratio of 4:1 to prepare a syrup.
비교예comparative example 13. 일부 성분이 배제된 조성물의 제조 13. Preparation of a composition excluding some components
실시예 1에 대하여, 이소말토올리고당, D-l 멘톨, 유산균, 글루코만난을 배제하고 비교예 13의 조성물을 제조해보았다.With respect to Example 1, the composition of Comparative Example 13 was prepared by excluding isomaltooligosaccharide, D-1 menthol, lactic acid bacteria, and glucomannan.
추출단계(S10): 다시마 6.25중량%, 귤피 6.25중량%, 칡꽃 6.25중량%, 헛개나무 6.25중량%, 대추 6.25중량%, 구기자뿌리 6.25중량%, 녹차어린잎 6.25중량%, 사철쑥 6.25중량%, 사인 6.25중량%, 국화 6.25중량%, 침향 6.25중량% 및 정제수 31.25중량%를 혼합한 생약재혼합물에, 정제수와 에탄올을 3 : 7 중량비로 혼합한 추출용매 2,000 mL를 가하고, 70 내지 75℃의 온도로 10시간 동안 진공상태에서 추출하여 생약재 추출물을 제조하였다.Extraction step (S10): kelp 6.25% by weight, tangerine peel 6.25% by weight, arrowroot 6.25% by weight, Heotgae tree 6.25% by weight, jujube 6.25% by weight, goji root 6.25% by weight, green tea young leaves 6.25% by weight, mugwort 6.25% by weight, To the herbal medicine mixture mixed with sine 6.25% by weight, chrysanthemum 6.25% by weight, aloesaceae 6.25% by weight and purified water 31.25% by weight, 2,000 mL of an extraction solvent obtained by mixing purified water and ethanol in a 3: 7 weight ratio was added, and the temperature of 70 to 75 ℃ A herbal extract was prepared by extraction under vacuum for 10 hours.
농축 단계(S20): 상기 추출단계(S10)에서 얻은 생약재추출물 4000mL를 진공 저온 농축 방법으로 800mL로 농축하여 생약재 농축액을 제조하였다.Concentration step (S20): 4000 mL of the herbal extract obtained in the extraction step (S10) was concentrated to 800 mL by vacuum low temperature concentration to prepare a herbal concentrate.
생약재분말 제조 단계(S30): 다시마 6.25중량%, 귤피 6.25중량%, 칡꽃 6.25중량%, 헛개나무 6.25중량%, 대추 6.25중량%, 구기자뿌리 6.25중량%, 녹차어린잎 6.25중량%, 사철쑥 6.25중량%, 사인 6.25중량%, 국화 6.25중량%, 침향 6.25중량% 및 정제수 31.25중량%를 혼합한 생약재혼합물을, 건조기에서 60 내지 65℃의 온도로 10시간 동안 건조하고, 분쇄하여 100 mesh의 생약재 분말을 제조하였다.Herbal medicine powder manufacturing step (S30): kelp 6.25% by weight, tangerine peel 6.25% by weight, arrowroot 6.25% by weight, Heotgae tree 6.25% by weight, jujube 6.25% by weight, goji root 6.25% by weight, green tea young leaves 6.25% by weight, mugwort 6.25% by weight %, sine 6.25% by weight, chrysanthemum 6.25% by weight, amethyst 6.25% by weight, and purified water 31.25% by weight of the herbal medicine mixture, dried in a dryer at a temperature of 60 to 65 ℃ for 10 hours, pulverized and 100 mesh herbal medicine powder was prepared.
시럽 제조 단계(S41): 농축 단계(S20)에서 제조된 생약재농축액과 생약재분말 제조 단계(S30)에서 제조된 생약재분말을 4 : 1의 중량비로 혼합하여 시럽제를 제조하였다.Syrup preparation step (S41): The herbal medicine concentrate prepared in the concentration step (S20) and the herbal medicine powder prepared in the herbal medicine powder preparation step (S30) were mixed in a weight ratio of 4:1 to prepare a syrup.
실험예Experimental example 1. 숙취 해소용 조성물의 1. Composition for relieving hangover ADHADH 활성 측정 Activity measurement
상기 실시예 1과 비교예 1 내지 13에서 제조된 조성물의 ADH 활성 측정 실험을 하였다.ADH activity measurement experiment was performed on the compositions prepared in Example 1 and Comparative Examples 1 to 13.
알코올 및 아세트알데하이드 분석 kit를 사용하여 상기 실시예 1과 비교예 1 내지 13의 조성물을 각각 증류수에 1㎎/㎖로 녹여 사용하였으며 처리군과 대조군(증류수)의 반응 생성물인 NADH 생성량을 자외선분광광도기(UV spectrophotometer)를 사용하여 340nm에서 흡광도를 측정하였다. 각각의 조성물의 활성은 in vitro assay system을 이용하여 측정하여 대조구에 대한 상대율로 표시하였다. 실험결과는 하기 표 1에 나타내었다.Using an alcohol and acetaldehyde analysis kit, the compositions of Example 1 and Comparative Examples 1 to 13 were each dissolved in distilled water at 1 mg/ml, and the amount of NADH produced by the reaction product of the treatment group and control group (distilled water) was measured by ultraviolet spectroscopy. The absorbance was measured at 340 nm using a UV spectrophotometer. The activity of each composition was measured using an in vitro assay system and expressed as a relative ratio to the control group. The experimental results are shown in Table 1 below.
실험예Experimental example 2. 숙취해소용 조성물의 혈중 알코올 농도 저하 측정 2. Measurement of the decrease in blood alcohol concentration of the composition for relieving hangover
상기 실시예 1과 비교예 1 내지 13에서 제조된 조성물의 혈중 알코올 농도 저하 측정 실험을 하였다.An experiment for measuring a decrease in blood alcohol concentration of the compositions prepared in Example 1 and Comparative Examples 1 to 13 was performed.
실험에 사용한 쥐는 생후 6주령의 수컷 SD(Sprague-Dawley) 흰쥐이며, 1주일간 고형배합사료(삼양배합사료)와 물로 사육시켰으며, 동물사육의 환경은 온도 23±1℃, 습도 50±5%로 조정하였고, 12시간 명암주기를 유지하였다. 동물실험은 증류수를 투여한 대조군, 본 발명의 숙취해소용 조성물(실시예 1) 투여군 및 실시예 1과 비교예 1 내지 13의 조성물을 각각 1.5ｇ/㎏의 양으로 음용수에 녹여 실험 대상 쥐에 1㎖씩 경구투여하여 하였다. 경구투여 30분 후, 40% 에탄올 수용액 1㎖를 경구투여하였으며, 40% 에탄올 수용액 투여 전과 투여 후, 1, 3 및 5시간에 쇄골하지정맥으로부터 0.2㎖의 혈액을 채취하여 혈청을 얻었으며, EnzyChrom Ethanol Assay Kit를 이용하여 반응시킨 후 570㎚에서 흡광도를 측정하였다. 실험결과는 하기 표 2에 나타내었다.The mice used in the experiment were 6-week-old male SD (Sprague-Dawley) rats, and were bred for 1 week with solid mixed feed (Samyang mixed feed) and water. was adjusted, and a 12-hour light-dark cycle was maintained. In the animal experiment, the control group administered with distilled water, the composition for relieving a hangover of the present invention (Example 1), and the compositions of Examples 1 and Comparative Examples 1 to 13 were dissolved in drinking water in an amount of 1.5 g/kg, respectively, to the mice subjected to the experiment. 1 ml each was orally administered. 30 minutes after oral administration, 1 ml of 40% aqueous ethanol solution was orally administered, and 0.2 ml of blood was collected from the subclavian vein before and 1, 3, and 5 hours after administration of 40% aqueous ethanol solution to obtain serum, EnzyChrom After reacting using Ethanol Assay Kit, absorbance was measured at 570 nm. The experimental results are shown in Table 2 below.
실험예Experimental example 3. 숙취해소용 조성물의 숙취해소 효과 평가 3. Evaluation of hangover relieving effect of hangover relieving composition
상기 실시예 1과 비교예 1 내지 13에서 제조된 조성물의 숙취해소 효과 평가를 하였다.The hangover relieving effect of the compositions prepared in Example 1 and Comparative Examples 1 to 13 was evaluated.
20대 성인남자 160명을 대상으로 하였으며, 실험 대상자(140명)에게 시판 소주(알코올 20%) 300㎖를 섭취하게 하고 30분 후에 상기 실시예 1과 비교예 1 내지 13의 조성물을 0.15ｇ/㎏의 양으로 음용수에 녹이고 각각 10명씩 총 14그룹으로 나누어 75㎖씩 섭취하게 하였다. 숙취해소 효과는 5점 척도법으로 다음날 음주에 따라 나타나는 숙취현상인 두통 및 갈증의 정도(증상이 나타나지 않음: 5점, 증상이 거의 없음: 4점, 증상이 보통임: 3점, 증상이 약간 나타남: 2점, 증상이 매우 심함: 1점)에 따라 비교 평가를 하였다.160 adult males in their twenties were targeted, and the experimental subjects (140 people) were allowed to ingest 300 ml of commercially available soju (20% alcohol), and after 30 minutes, 0.15 g/ Dissolved in drinking water in an amount of kg, and divided into 14 groups of 10 people each, and ingested 75 ml each. The hangover relieving effect is a five-point scale, and the degree of headache and thirst, which is a hangover phenomenon that occurs following drinking the next day (no symptoms: 5 points, few symptoms: 4 points, moderate symptoms: 3 points, slight symptoms) : 2 points, symptoms very severe: 1 point), comparative evaluations were made.
실험예Experimental example 4. 동물 실험 4. Animal Testing
실시예 1에서 제조된 조성물에 대하여 알코올 함량 분석, 아세트알데히드 함량 분석, 알코올 탈수소효소 함량 분석 및 간 기능검사를 수행하였다.Alcohol content analysis, acetaldehyde content analysis, alcohol dehydrogenase content analysis and liver function test were performed on the composition prepared in Example 1.
사용된 시약은 ethanol(Merck Millipore, U.S.A.), ethanol assay kit(Bioassay Systems, U.S.A.), acetaldehyde assay kit(Bioassay Systems, U.S.A), alcohol dehydrogenase(Bioassay Systems, U.S.A.) 등을 사용하였다.The reagents used were ethanol (Merck Millipore, U.S.A.), ethanol assay kit (Bioassay Systems, U.S.A.), acetaldehyde assay kit (Bioassay Systems, U.S.A.), alcohol dehydrogenase (Bioassay Systems, U.S.A.), and the like.
사용된 기기는 autoclave(Sanyo, Japan), vortex mixer(Vision scientific, Korea), centrifuge(Hanil, Korea), plate shaker(Lab-Line, U.S.A.), micro plate reader(Molecular Devices, U.S.A.), biochemistry auto analyser(Beckman Coulter, U.S.A.) 등을 사용하였다.The instruments used were autoclave (Sanyo, Japan), vortex mixer (Vision scientific, Korea), centrifuge (Hanil, Korea), plate shaker (Lab-Line, U.S.A.), micro plate reader (Molecular Devices, U.S.A.), biochemistry auto analyzer (Beckman Coulter, U.S.A.) et al.
본 실험을 위하여 사용된 SD.rat(5주령, 수컷, 150 ~180g)는 (주)라온바이오(Korea)에서 구입하여 사용하였다. 실험동물은 2주간의 안정기를 가지면서 순화를 시켰으며, 안정기 및 실험기간에 모든 실험군에는 일반 사료(Altromin, Germany)를 자유식이 하며 물을 충분히 공급하였다. 동물 사육실의 조건은 conventional system으로 22±2℃, 1일 중 12시간은 200-300 Lux로 조명하고, 12시간은 모든 빛을 차단하였다. 본 실험은 대전대학교 동물실험윤리 위원회의 승인(승인번호 DJUARB2019-023)을 받아 동물윤리준칙에 의거하여 시럼하였다.SD.rat (5 weeks old, male, 150 ~ 180g) used for this experiment was purchased from Raon Bio (Korea) and used. Experimental animals were acclimatized while having a stable period of 2 weeks, and during the stabilization period and the experimental period, all experimental groups were fed a general diet (Altromin, Germany) ad libitum and were supplied with sufficient water. The conditions of the animal breeding room were 22±2℃ with a conventional system, 200-300 Lux for 12 hours a day, and all light was blocked for 12 hours. This experiment was approved by the Animal Experiment Ethics Committee of Daejeon University (approval number DJUARB2019-023) and was conducted in accordance with the Animal Ethics Rules.
18시간의 절식시킨 대조군과 실험군에는 3g/kg의 알코올을 투여하였으며, 알코올 투여 30분 후에 대조군에는 증류수, 실험군에는 시료를 2mL 씩 투여하였다.After 18 hours of fasting, 3 g/kg of alcohol was administered to the control group and the experimental group. After 30 minutes of alcohol administration, distilled water was administered to the control group and 2 mL samples were administered to the experimental group.
알코올 투여 1시간, 3시간, 5시간 후에 실험동물의 꼬리정맥에서 혈액을 체취하였으며, 이를 상온에서 30분간 굳히고, 원심분리를 통해 혈청으로 분리하였으며, 초저온 냉동(-80℃) 보관하면서 실험에 사용하였다.After 1 hour, 3 hours, and 5 hours of alcohol administration, blood was collected from the tail vein of the experimental animals, hardened at room temperature for 30 minutes, separated into serum by centrifugation, and stored in cryogenic freezing (-80℃) for use in the experiment. did.
이를 이용하여, 하기 실험예 4.1.의 알코올 함량분석, 실험예 4.2.의 아세트알데히드 함량분석, 실험예 4.3.의 알코올 탈수소효소 함량분석 및 실험예 4.4.의 간 기능 검사에 이용하였다.Using this, it was used for the alcohol content analysis of Experimental Example 4.1., the acetaldehyde content analysis of Experimental Example 4.2., the alcohol dehydrogenase content analysis of Experimental Example 4.3. and the liver function test of Experimental Example 4.4.
각 실험의 결과는 SPSS 21.0를 이용하여 mean±standard error of mean으로 나타내었으며, ANOVA를 사용하여 다중 비교하였고 Turkey's HSD test를 통해 p<0.05, p<0.01 및 p<0.001 수준에서 유의성을 검정하였다. The results of each experiment were expressed as mean±standard error of mean using SPSS 21.0, multiple comparisons were performed using ANOVA, and significance was tested at p<0.05, p<0.01, and p<0.001 levels through Turkey's HSD test.
실험예Experimental example 4.1. 알코올 함량분석 4.1. Alcohol content analysis
96 well plate에 2배 희석한 혈청을 100㎕씩 넣고 reagent A 100㎕를 추가하여 상온에서 30분간 반응시켰다. 반응시킨 후, stop reagent B 100㎕를 추가하고 micro plate reader를 통해 580nm 파장에서 측정하여 함량을 계산하였다.100 μl of 2-fold diluted serum was added to a 96 well plate, 100 μl of reagent A was added, and reacted at room temperature for 30 minutes. After the reaction, 100 μl of stop reagent B was added, and the content was calculated by measuring at a wavelength of 580 nm through a micro plate reader.
혈액 내 알코올 함량을 분석한 결과, 실험군은 모든 시간에서 대조군에 비해 유의성 있는 감소를 나타내었다.As a result of analyzing the alcohol content in the blood, the experimental group showed a significant decrease compared to the control group at all times.
실험예Experimental example 4.2. 아세트알데히드 함량분석 4.2. Acetaldehyde content analysis
96 well plate에 혈청을 20㎕씩 2well에 넣고, 1well에는 working reagent 80㎕를, 다른 well 에는 blank working reagent 80㎕를 추가하여 상온에서 30분간 반응 시켰다. 반응시킨 후, micro plate reader를 통해 565nm 파장에서 측정하여 함량을 계산하였다.In a 96 well plate, 20 μl of serum was put into 2 wells, 80 μl of working reagent was added to 1 well, and 80 μl of blank working reagent was added to other wells, and the reaction was carried out at room temperature for 30 minutes. After the reaction, the content was calculated by measuring at a wavelength of 565 nm through a micro plate reader.
혈액 내 아세트알데히드 함량을 분석한 결과, 실험군은 3시간과 5시간 후에서 대조군에 비해 유의성 있는 감소를 나타내었다.As a result of analyzing the acetaldehyde content in the blood, the experimental group showed a significant decrease compared to the control group after 3 and 5 hours.
실험예Experimental example 4.3. 알코올 탈수소효소 함량분석 4.3. Analysis of alcohol dehydrogenase content
96 well plate에 혈청을 20㎕씩 2well에 넣고, 1well에는 working reagent 80㎕를, 다른 well 에는 blank working reagent 80㎕를 추가하여 micro plate reader를 통해 565nm 파장에서 측정하였다. 이후, 상온에서 30분간 반응시킨 후, 가시 한번 micro plate reader를 통해 565nm 파장에서 측정하여 함량을 계산하였다.In a 96 well plate, 20 μl of serum was put into 2 wells, 80 μl of working reagent was added to 1 well, and 80 μl of blank working reagent was added to other wells, and the result was measured at 565 nm wavelength through a micro plate reader. Thereafter, after reacting at room temperature for 30 minutes, the content was calculated by measuring at a wavelength of 565 nm through a micro plate reader once visible.
혈액 내 알코올 탈수소효소 함량을 분석한 결과, 실험군은 모든 시간에서 대조군에 비해 오의성 있는 증가를 나타내었다.As a result of analyzing the alcohol dehydrogenase content in the blood, the experimental group showed a false increase compared to the control group at all times.
실험예Experimental example 4.4. 간 기능 검사 4.4. liver function test
분리한 혈청 300㎕를 biochemistry auto analyser에 주입하고 진단검사 의학적 가이드라인(cilinical and laboratory standards institue, CLSI)를 기준으로 간 기능 지표인자인 AST(aspartate aminotransferase), ALT(alanine aminotransferase), ALP(alkaline phosphatase) 함량을 분석하였다.300 μl of the isolated serum is injected into a biochemistry auto analyzer, and liver function indicators AST (aspartate aminotransferase), ALT (alanine aminotransferase), ALP (alkaline phosphatase) based on the medical and laboratory standards institute (CLSI) ) content was analyzed.
혈액을 통한 생화학 분석 결과, 실험군은 AST와 ALP에서 대조군에 비해 유의성 있는 감소를 나타내었으나, ALT에서는 차이를 나타내지 않았다.As a result of biochemical analysis through blood, the experimental group showed a significant decrease in AST and ALP compared to the control group, but did not show a difference in ALT.
결론.conclusion.
상기 실시예, 비교예 및, 실험예를 통해 확인한 바와 같이, 본 발명에 따른 조성물은 숙취 개선 효과가 있음을 확인할 수 있었다.As confirmed through the Examples, Comparative Examples, and Experimental Examples, it was confirmed that the composition according to the present invention has a hangover improvement effect.
실험예 1 내지 4를 통하여, 본 발명에 따른 숙취 개선용 조성물은 ADH 활성이 우수하고, 혈중 알코올 농도 빠르게 하강하며, 관능 평가에 있어서도 숙취개선 효과를 가짐을 확인할 수 있었다. 또한, 개별적인 구성성분에 비해, 이들이 조합되었을 때 시너지 효과가 나타나는 것을 확인할 수 있었으며, 이들의 조합에 따라 예기치 못한 효과가 나타났음을 확인할 수 있었다.Through Experimental Examples 1 to 4, it was confirmed that the composition for improving hangover according to the present invention had excellent ADH activity, rapidly lowered blood alcohol concentration, and had a hangover improvement effect in sensory evaluation. In addition, compared to the individual components, it could be confirmed that a synergistic effect appears when they are combined, and it can be confirmed that an unexpected effect appears according to the combination thereof.
또한, 일부 구성이 배제된 조성물에 비해, 모든 구성성분을 포함하는 실시예 1의 조성물이 갖는 효과가 우수함을 확인할 수 있었다.In addition, compared to the composition in which some components were excluded, it was confirmed that the effect of the composition of Example 1 including all components was excellent.
이에, 본 발명은 다시마, 귤피, 칡꽃, 헛개나무, 대추, 구기자뿌리, 녹차어린잎, 사철쑥, 사인, 국화, 침향, 이소말토올리고당, D-l 멘톨, 유산균, 글루코만난 및 정제수를 혼합한 생약재혼합물을 포함하여 숙취 개선 효과를 갖는 숙취 개선용 조성물을 개발하였음을 명시한다.Accordingly, the present invention includes a herbal medicine mixture mixed with kelp, tangerine peel, arrowroot flower, horseradish tree, jujube, goji root, green tea young leaf, wormwood, sage, chrysanthemum, aloes, isomaltooligosaccharide, D-1 menthol, lactic acid bacteria, glucomannan and purified water. to indicate that a composition for improving a hangover having a hangover improvement effect has been developed.
본 발명을 첨부된 도면과 함께 설명하였으나, 이는 본 발명의 요지를 포함하는 다양한 실시 형태 중의 하나의 실시 예에 불과하며, 당 업계에서 통상의 지식을 가진 자가 용이하게 실시할 수 있도록 하는 데에 그 목적이 있는 것으로, 본 발명은 상기 설명된 실시예에만 국한되는 것이 아님은 명확하다. 따라서, 본 발명의 보호범위는 하기의 청구범위에 의해 해석되어야 하며, 본 발명의 요지를 벗어나지 않는 범위 내에서 변경, 치환, 대체 등에 의해 그와 동등한 범위 내에 있는 모든 기술 사상은 본 발명의 권리에 포함될 것이다. 또한, 도면의 일부 구성은 구성을 보다 명확하게 설명하기 위한 것으로 실제보다 과장되거나 축소되어 제공되는 것임을 명확히 한다.Although the present invention has been described with the accompanying drawings, this is only one embodiment of various embodiments including the gist of the present invention, and is intended to be easily implemented by those of ordinary skill in the art. For the purpose, it is clear that the present invention is not limited to the embodiments described above. Therefore, the protection scope of the present invention should be construed by the following claims, and all technical ideas within the equivalent range by changes, substitutions, substitutions, etc. within the scope not departing from the gist of the present invention are in the right of the present invention. will be included In addition, it is clear that some components of the drawings are provided to be exaggerated or reduced than the actual ones for more clearly explaining the configuration.
(S10): 추출 단계
(S20): 농축 단계
(S30): 생약재분말 제조 단계
(S41): 시럽 제조단계
(S42): 약제 제조단계(S10): extraction step
(S20): Concentration step
(S30): herbal medicine powder manufacturing step
(S41): syrup manufacturing step
(S42): drug manufacturing step
Claims (5)
Kelp 6.0 ~ 10.0% by weight, tangerine peel 6.0 ~ 10.0% by weight, arrowroot 6.0 ~ 10.0% by weight, Heotgae tree 6.0 ~ 10.0% by weight, jujube 6.0 ~ 10.0% by weight, Goji root 6.0 ~ 10.0% by weight, green tea leaves 6.0 ~ 10.0 wt%, mugwort 6.0 ~ 10.0% by weight, sage 6.0 ~ 10.0% by weight, chrysanthemum 6.0 ~ 10.0% by weight, aloes 6.0 ~ 10.0% by weight, isomaltooligosaccharide 6.0 ~ 10.0% by weight, Dl menthol 6.0 ~ 10.0% by weight, lactic acid bacteria 6.0 ~ 10.0% by weight, glucomannan 6.0 ~ 10.0% by weight, and purified water 6.0 ~ 10.0% by weight of a herbal medicine mixture comprising a composition for improving hangover.
상기 생약재혼합물을 추출하고 농축한 생약재농축액과, 상기 생약재혼합물을 건조 분쇄한 생약재분말을 서로 혼합한 것을 특징으로 하는 숙취 개선용 조성물.
The method of claim 1,
A composition for improving hangover, characterized in that the herbal medicine concentrate extracted and concentrated of the herbal medicine mixture and the herbal medicine powder obtained by drying and pulverizing the herbal medicine mixture are mixed with each other.
상기 추출 단계(S10)에서 추출된 생약재추출물을 농축하여, 생약재농축액을 제조하는 농축 단계(S20)
다시마 6.0 ~ 10.0중량%, 귤피 6.0 ~ 10.0중량%, 칡꽃 6.0 ~ 10.0중량%, 헛개나무 6.0 ~ 10.0중량%, 대추 6.0 ~ 10.0중량%, 구기자뿌리 6.0 ~ 10.0중량%, 녹차어린잎 6.0 ~ 10.0중량%, 사철쑥 6.0 ~ 10.0중량%, 사인 6.0 ~ 10.0중량%, 국화 6.0 ~ 10.0중량%, 침향 6.0 ~ 10.0중량%, 이소말토올리고당 6.0 ~ 10.0중량%, D-l 멘톨 6.0 ~ 10.0중량%, 유산균 6.0 ~ 10.0중량%, 글루코만난 6.0 ~ 10.0중량% 및 정제수 6.0 ~ 10.0중량%를 혼합하여 생약재혼합물을 제조하고, 건조 분쇄하여, 생약재분말을 제조하는 생약재분말 제조 단계(S30)
상기 농축 단계(S20)에서 제조된 생약재농축액과 상기 생약재분말 제조 단계(S30)에서 제조된 생약제 분말을 혼합하여 시럽을 제조하는 시럽 제조단계(S41)를 포함하는 것을 특징으로 하는 숙취 개선용 조성물의 제조방법.
Kelp 6.0 ~ 10.0% by weight, tangerine peel 6.0 ~ 10.0% by weight, arrowroot 6.0 ~ 10.0% by weight, Heotgae tree 6.0 ~ 10.0% by weight, jujube 6.0 ~ 10.0% by weight, Goji root 6.0 ~ 10.0% by weight, green tea leaves 6.0 ~ 10.0 wt%, mugwort 6.0 ~ 10.0% by weight, sage 6.0 ~ 10.0% by weight, chrysanthemum 6.0 ~ 10.0% by weight, aloes 6.0 ~ 10.0% by weight, isomaltooligosaccharide 6.0 ~ 10.0% by weight, Dl menthol 6.0 ~ 10.0% by weight, lactic acid bacteria 6.0 ~ 10.0 wt%, glucomannan 6.0 ~ 10.0 wt%, and purified water 6.0 ~ 10.0% by weight to prepare a herbal medicine mixture, extracting the herbal extract from the herbal medicine mixture (S10)
Concentrating the herbal medicine extract extracted in the extraction step (S10) to prepare a herbal medicine concentrate (S20)
Kelp 6.0 ~ 10.0% by weight, tangerine peel 6.0 ~ 10.0% by weight, arrowroot 6.0 ~ 10.0% by weight, Heotgae tree 6.0 ~ 10.0% by weight, jujube 6.0 ~ 10.0% by weight, Goji root 6.0 ~ 10.0% by weight, green tea leaves 6.0 ~ 10.0 wt%, mugwort 6.0 ~ 10.0% by weight, sage 6.0 ~ 10.0% by weight, chrysanthemum 6.0 ~ 10.0% by weight, aloes 6.0 ~ 10.0% by weight, isomaltooligosaccharide 6.0 ~ 10.0% by weight, Dl menthol 6.0 ~ 10.0% by weight, lactic acid bacteria 6.0 ~ 10.0% by weight, glucomannan 6.0 ~ 10.0% by weight, and purified water 6.0 ~ 10.0% by weight to prepare a herbal medicine mixture, dry and pulverize to prepare a herbal medicine powder manufacturing step (S30)
A composition for improving hangover, characterized in that it comprises a syrup preparation step (S41) of preparing a syrup by mixing the herbal medicine concentrate prepared in the concentration step (S20) and the herbal medicine powder prepared in the herbal medicine powder production step (S30) manufacturing method.
상기 추출 단계(S10)에서 추출된 생약재추출물을 농축하여, 생약재농축액을 제조하는 농축 단계(S20);
다시마 6.0 ~ 10.0중량%, 귤피 6.0 ~ 10.0중량%, 칡꽃 6.0 ~ 10.0중량%, 헛개나무 6.0 ~ 10.0중량%, 대추 6.0 ~ 10.0중량%, 구기자뿌리 6.0 ~ 10.0중량%, 녹차어린잎 6.0 ~ 10.0중량%, 사철쑥 6.0 ~ 10.0중량%, 사인 6.0 ~ 10.0중량%, 국화 6.0 ~ 10.0중량%, 침향 6.0 ~ 10.0중량%, 이소말토올리고당 6.0 ~ 10.0중량%, D-l 멘톨 6.0 ~ 10.0중량%, 유산균 6.0 ~ 10.0중량%, 글루코만난 6.0 ~ 10.0중량% 및 정제수 6.0 ~ 10.0중량%를 혼합하여 생약재혼합물을 제조하고, 건조 분쇄하여, 생약재분말을 제조하는 생약재분말 제조 단계(S30); 및,
상기 농축 단계(S20)에서 제조된 생약재농축액과 상기 생약재분말 제조 단계(S30)에서 제조된 생약제 분말을 혼합하여 과립제, 산제 또는, 환제로 제조하는 약제 제조단계(S42)를 포함하는 것을 특징으로 하는 숙취 개선용 조성물의 제조방법.
Kelp 6.0 ~ 10.0% by weight, tangerine peel 6.0 ~ 10.0% by weight, arrowroot flower 6.0 ~ 10.0% by weight, Heotgae tree 6.0 ~ 10.0% by weight, jujube 6.0 ~ 10.0% by weight, Goji root 6.0 ~ 10.0% by weight, green tea leaves 6.0 ~ 10.0 wt%, mugwort 6.0 ~ 10.0% by weight, sage 6.0 ~ 10.0% by weight, chrysanthemum 6.0 ~ 10.0% by weight, aloes 6.0 ~ 10.0% by weight, isomaltooligosaccharide 6.0 ~ 10.0% by weight, Dl menthol 6.0 ~ 10.0% by weight, lactic acid bacteria 6.0 ~ 10.0 wt%, glucomannan 6.0 ~ 10.0 wt%, and purified water 6.0 ~ 10.0 wt% to prepare a herbal medicine mixture, extracting the herbal extract from the herbal medicine mixture extraction step (S10);
Concentrating the herbal medicine extract extracted in the extraction step (S10) to prepare a herbal medicine concentrate (S20);
Kelp 6.0 ~ 10.0% by weight, tangerine peel 6.0 ~ 10.0% by weight, arrowroot flower 6.0 ~ 10.0% by weight, Heotgae tree 6.0 ~ 10.0% by weight, jujube 6.0 ~ 10.0% by weight, Goji root 6.0 ~ 10.0% by weight, green tea leaves 6.0 ~ 10.0 wt%, mugwort 6.0 ~ 10.0% by weight, sage 6.0 ~ 10.0% by weight, chrysanthemum 6.0 ~ 10.0% by weight, aloes root 6.0 ~ 10.0% by weight, isomaltooligosaccharide 6.0 ~ 10.0% by weight, Dl menthol 6.0 ~ 10.0% by weight, lactic acid bacteria 6.0 ~ 10.0% by weight, glucomannan 6.0 ~ 10.0% by weight, and purified water 6.0 ~ 10.0% by weight to prepare a herbal medicine mixture, dry and pulverized to prepare a herbal medicine powder manufacturing step (S30); and,
A pharmaceutical preparation step (S42) of mixing the herbal medicine concentrate prepared in the concentration step (S20) and the herbal medicine powder prepared in the herbal medicine powder production step (S30) to prepare granules, powders, or pills (S42) characterized in that it comprises Method for producing a composition for improving hangover.
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| KR101827326B1 (en) | 2016-02-04 | 2018-02-09 | 문수영 | Chinese medical composition for curing a hangover |
| KR20210116929A (en) * | 2020-03-18 | 2021-09-28 | 주식회사 케이에스하니 | Method for manufacturing hangover recovery agent and hangover recovery agent manufactured by the same |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| KR101827326B1 (en) | 2016-02-04 | 2018-02-09 | 문수영 | Chinese medical composition for curing a hangover |
| KR20210116929A (en) * | 2020-03-18 | 2021-09-28 | 주식회사 케이에스하니 | Method for manufacturing hangover recovery agent and hangover recovery agent manufactured by the same |
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| [Gilbeom Column] Tips for choosing the right hangover cure. voice of the people. [online], 2019.10.14., [2022.03.21. Search], Internet: <https://www.vop.co.kr/A00001440991.html> * |
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