KR102439636B1 - Composition for alleviating muscle tics and depression and manufacturing method thereof - Google Patents
Composition for alleviating muscle tics and depression and manufacturing method thereof Download PDFInfo
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Abstract
Description
본 발명은 근육틱 및 우울증 개선용 조성물 및 그 제조방법에 관한 것으로, 더 자세하게는, 산조인, 천마, 백잠감, 감국, 구기자, 길경, 당귀, 맥문동, 백복신, 백출, 산사육, 산약, 용안육, 우슬, 작약, 대추, 오미자, 원지, 죽여, 감초 및 계피를 혼합한 생약재혼합물을 포함하여 근육틱 및 우울증 개선 효과를 갖도록 한 근육틱 및 우울증 개선용 조성물 및 그 제조방법에 관한 것이다.The present invention relates to a composition for improving muscle tics and depression and a method for producing the same, and more particularly, sanjoin, cheonma, baekjamgam, gamguk, gugija, gilgyeong, angelica, maekmundong, baekbokshin, baekchul, sansayuk, sanyak, longanyuk, wooseul , peony, jujube, omija, raw paper, porridge, licorice and cinnamon, including a herbal mixture mixed with cinnamon, to have the effect of improving muscle tics and depression, and to a composition for improving muscle tics and depression, and a method for manufacturing the same.
일반적으로 신체는 스트레스에 대항하기 위해 내분비계, 자율신경계 등에 변화가 일어나며, 지속적이고 만성적인 스트레스는 우울, 불안, 분노 등의 심리적 변화를 수반한다. 우울증은 단순히 지나가는 우울감과는 다르며, 심해지면 신체기능 및 인지기능에도 영향을 미쳐 일상생활을 어려워지게 하는 심각한 질병이다. 우울증의 원인은 명확하게 밝혀져 있지 않으며, 유전학적, 생물학적, 심리사회학적 요인들이 복합적으로 작용하여 발병하는 것으로 인식되고 있으며, 신체질환이나 약물에 의해서도 우울증이 발병될 수 있다. 대부분의 우울증 환자는 식욕부진으로 충분한 영양 공급을 받지 못하며, 침울한 정신상태로 인하여 생리기운이 침체되어 변비, 소화기와 관련된 증상 등이 나타난다.In general, the body undergoes changes in the endocrine system and autonomic nervous system to counter stress, and continuous and chronic stress is accompanied by psychological changes such as depression, anxiety, and anger. Depression is different from a simple feeling of depression, and when it gets worse, it is a serious disease that affects physical and cognitive functions, making daily life difficult. The cause of depression is not clearly known, and genetic, biological, and psychosocial factors are recognized to cause it in a complex way, and depression can also be caused by physical diseases or drugs. Most depressed patients do not receive sufficient nutrition due to anorexia, and menstrual energy is stagnated due to a depressed mental state, resulting in constipation and digestive symptoms.
최근 사회는 변화의 속도가 빨라지면서, 변화에 따라가기 위한 스트레스는 많아지고, 핵가족화로 인해 정서적 안정감은 감소하여 정신적 질환의 유병률이 증가하는 추세에 있다. 우리나라도 도시화가 가속되면서 우울증의 발병률이 증가하고 있으며, 급증하는 자살의 원인에 우울증이 포함된다. 우울증의 치료방법, 항우울제에 대한 지속적인 연구가 필요한 실정이다.In recent society, as the speed of change increases, the stress to keep up with the changes increases, and the emotional stability decreases due to the nuclear family, and the prevalence of mental diseases is increasing. As urbanization accelerates in Korea, the incidence of depression is also increasing, and depression is included in the cause of the rapidly increasing number of suicides. There is a need for continuous research on treatment methods for depression and antidepressants.
현대의학은 우울증을 세로토닌의 문제로 인식하고 있으며, 우울증 치료제로 세로토닌의 분비를 조절하는 항우울제를 처방한다. 주요우울증을 가진 사람은 전형적으로 뇌에서 신경전달물질의 불균형을 나타내는데, 중추신경계의 시냅스 내에 모노아민계 신경전달물질인 세로토닌, 노르에피네프린, 도파민 등이 부족하여 우울증이 유발된다. 따라서, 대부분의 항우울제는 뇌의 화학적 불균형을 조절하는 것으로, 중추신경계의 시냅스 내에 있는 신경전달물질의 농도를 높이는 약리작용을 가지고 있다. 항우울제는 신경전달물질의 농도를 높이는 기전에 따라 삼환계 항우울제, 모노아민 옥시다제 억제제, 또는 선택적 세로토닌 재흡수 억제제 등으로 나뉜다. 이러한 항우울제가 우울증 치료에 효과적이기는 하나, 두통, 현기증, 구토, 수면장애, 혈압저하, 근육경련 등의 부작용 및 중독성의 문제점이 있다.Modern medicine recognizes depression as a serotonin problem, and as a treatment for depression, antidepressants that control the secretion of serotonin are prescribed. People with major depression typically show an imbalance of neurotransmitters in the brain, and depression is caused by a lack of monoamine neurotransmitters such as serotonin, norepinephrine, and dopamine in the synapses of the central nervous system. Therefore, most antidepressants control the chemical imbalance of the brain, and have a pharmacological action to increase the concentration of neurotransmitters in the synapses of the central nervous system. Antidepressants are classified into tricyclic antidepressants, monoamine oxidase inhibitors, and selective serotonin reuptake inhibitors according to the mechanism of increasing the concentration of neurotransmitters. Although these antidepressants are effective in treating depression, they have side effects such as headache, dizziness, vomiting, sleep disturbance, lowering blood pressure, muscle cramps, and the like and addictive problems.
한편, 우울증은 한의학에서 기울증(氣鬱證)으로 표현되는데, 이는 정신적인 문제 등에 의해 기가 제대로 순환되지 못하고 울체 또는 억압되어 나타나는 상태를 말한다. 한의학에서는 우울증과 같은 마음의 병을 몸과 마음의 부조화에 의한 것으로 보아, 기를 원활하게 풀어 심장의 감정조절 기능을 회복하는 것을 우선으로 하며, 오장육부에 쌓여있는 화기를 풀어 신진대사를 돕는 약제를 처방하여 치료한다. 한의학에서 사용되는 한약재는 심신이완의 효과가 있고, 영양이 부족한 우울증 환자의 기력보충에 도움을 준다.On the other hand, depression is expressed in oriental medicine as tilt (气鬱證), which refers to a state in which the qi is not properly circulated and is stagnant or suppressed due to mental problems. In oriental medicine, considering that mental illness such as depression is caused by the dissonance of the body and mind, the priority is to restore the emotional control function of the heart by smoothing out Qi. Prescribe and treat Herbal medicines used in oriental medicine have the effect of relaxing the mind and body and help replenish energy for depressed patients who lack nutrition.
경련은 총 인구의 1%에서 나타나는 비교적 흔한 질환이며, 뇌막염, 뇌암, 두뇌 외상, 대뇌 순환계의 퇴행성 질병 등이 원인으로 알려져 있다. 근래에는 교통사고와 안전사고의 급증, 향정신성 약물의 오남용, 과도한 전자기기 사용 등이 경련의 유발원인이 되고 있다. 경련은 억압되어 있다가 스트레스나 불안감에 의해 악화되고, 휴식이나 수면 중에는 일시적으로 호전을 보이기도 한다.Convulsions are a relatively common disease occurring in 1% of the total population, and are known to be caused by meningitis, brain cancer, brain trauma, and degenerative diseases of the cerebral circulatory system. Recently, a rapid increase in traffic accidents and safety accidents, misuse of psychotropic drugs, excessive use of electronic devices, etc. are the causes of convulsions. Convulsions are suppressed and aggravated by stress or anxiety, and sometimes improve temporarily during rest or sleep.
틱장애는 우세한 발현양식이 경련인 증후군으로, 갑자기 반복적이고 불수의적인 근육운동(근육틱)이나 소리(음성틱)를 내는 신경질환의 일종이다. 틱장애는 보통 아동에게서 나타나며 청소년기가 되면 사라지는 것으로 알려져 있으나, 스트레스나 외부 환경 요인으로 인해 성인기에도 발생한다. 틱장애는 대게 근육틱으로 발생하며, 틱장애 증상은 스트레스에 민감하다고 알려져 있다.Tic disorder is a syndrome in which the predominant mode of expression is convulsions, and is a kind of neurological disease in which sudden repetitive and involuntary muscle movements (muscular tics) or sounds (vocal tics) are produced. Tic disorder usually appears in children and is known to disappear in adolescence, but it also occurs in adulthood due to stress or external environmental factors. Tic disorders are usually caused by muscle tics, and the symptoms of tic disorders are known to be sensitive to stress.
일반적으로 틱장애 및 경련의 치료 방법으로 현대의학의 약물치료가 주를 이루고 있다. 현대 의학에서는 틱장애 및 경련의 원인을 기저핵과 대뇌의 신경전달체계의 이상으로 보며, 경련 및 틱장애를 치료 또는 예방하기 위해, 신경전달체계와 관련된 약물을 이용하여 치료를 한다. 항정신병 약물, 향경련 질환 약물, 항우울증 약물의 투여로 틱장애 및 경련 증상은 완화되나, 두통, 저혈압, 체중 증가, 인지적 둔감 등의 부작용이 있다. 일부에서는 항우울증 약물, 항경련 질환 약물, 항정신병약물 등이 틱장애를 유발하거나 증상 변화를 초래할 수 있다는 연구들이 보고되고 있다.In general, drug treatment of modern medicine is the main treatment method for tic disorders and convulsions. In modern medicine, the cause of tic disorders and convulsions is seen as abnormalities in the basal ganglia and cerebral neurotransmission systems, and in order to treat or prevent convulsions and tic disorders, drugs related to the neurotransmission system are used for treatment. The administration of antipsychotic drugs, anticonvulsant drugs, and antidepressants relieves tic disorders and convulsions, but has side effects such as headache, hypotension, weight gain, and cognitive desensitization. Some studies have reported that antidepressant drugs, anticonvulsant drugs, and antipsychotic drugs can cause tic disorders or change symptoms.
한편, 한의학에서는 경련 및 틱장애를 폐열, 폐허, 심열, 심허, 간열, 간기울결, 담음 등의 오장육부의 불균형이 뇌의 근육제어 체계에 이상을 유발하여 발병하는 것으로 본다. 한의학에서 전체적인 신체의 균형을 잡는 약제를 처방함으로써, 경련 증상을 완화시킴과 동시에 심리적인 안정에 도움을 준다.On the other hand, in oriental medicine, convulsions and tic disorders are considered to be caused by an imbalance of the five internal organs such as lung fever, lung disease, deep fever, shimheo, hepatic fever, hepatic depression, and dameum, which causes abnormalities in the brain's muscle control system. By prescribing drugs that balance the entire body in oriental medicine, it relieves convulsions and helps psychological stability.
상기와 같은 문제점을 해결하기 위하여, 본 출원인은 등록특허 제10-1826737호(2018.02.08.공고)를 통해, 생약재 추출물을 유효성분으로 하는 근육틱 및 우울증 개선용 조성물 및 그의 제조방법을 개시한적이 있다. 이는 감국, 구기자, 길경, 당귀, 맥문동, 더덕, 백복신, 백출, 산사육, 산약, 시호, 용안육, 우슬, 작약, 갈근, 대추, 오미자, 원지, 죽여, 감초 및 계피로 이루어진 생약재 혼합물을 추출, 농축, 분말 단계를 거쳐, 과립제, 산제, 환제로 제조함으로써, 근육틱 및 우울증의 개선에 효과가 있는 생약재 추출물을 유효성분으로 하는 근육틱 및 우울증 개선용 조성물 및 그의 제조방법에 관한 것이다.In order to solve the above problems, the present applicant has disclosed a composition for improving muscle tics and depression using a herbal extract as an active ingredient, and a method for preparing the same, through Registration Patent No. 10-1826737 (2018.02.08. Announcement). have. It extracts and concentrates a mixture of herbal medicines consisting of gamguk, gugija, gilgyeong, angelica, maekmundong, deodeok, baekbokshin, baekchul, sansayuk, sanyak, shiho, longanyuk, mussel, peony, galgeun, jujube, omija, raw paper, kill off, licorice and cinnamon. , to a composition for improving muscle tics and depression, and a method for preparing the same, comprising, as an active ingredient, a herbal extract effective in improving muscle tics and depression by producing granules, powders, and pills through a powder step.
그러나, 종래 본 출원인이 출원한 등록특허 제10-1826737호의 기술은 그 효과가 미미하다는 문제점이 있었다. 본 출원인은 이러한 기술을 시행하던 중, 보다 월등한 효과를 갖는 약재의 조합을 확인하였다.However, the conventional technique of Patent Registration No. 10-1826737 filed by the present applicant has a problem that the effect is insignificant. The present applicant has identified a combination of drugs having a superior effect while implementing these techniques.
상기와 같은 문제점을 해결하기 위하여, 본 발명은 산조인, 천마, 백잠감, 감국, 구기자, 길경, 당귀, 맥문동, 백복신, 백출, 산사육, 산약, 용안육, 우슬, 작약, 대추, 오미자, 원지, 죽여, 감초 및 계피를 혼합한 생약재혼합물을 포함하여 근육틱 및 우울증 개선 효과를 갖도록 한 근육틱 및 우울증 개선용 조성물 및 그 제조방법을 제공하는데 목적이 있다. In order to solve the above problems, the present invention is sanjoin, cheonma, baekjamgam, gamguk, gugija, gilgyeong, angelica, maekmundong, baekbokshin, baekchul, sansayuk, sanyak, longanyuk, wooseul, peony, jujube, omija, wonji, kill An object of the present invention is to provide a composition for improving muscle tics and depression, including a herbal medicine mixture mixed with licorice and cinnamon, and a method for improving muscle tics and depression, and a method for preparing the same.
상기와 같은 목적을 달성하기 위하여 본 발명은 산조인, 천마, 백잠감, 감국, 구기자, 길경, 당귀, 맥문동, 백복신, 백출, 산사육, 산약, 용안육, 우슬, 작약, 대추, 오미자, 원지, 죽여, 감초 및 계피를 혼합한 생약재혼합물을 포함하는 것을 특징으로 하는 근육틱 및 우울증 개선용 조성물을 제공한다.In order to achieve the above object, the present invention provides sanjoin, cheonma, baekjamgam, gamguk, gugija, gilgyeong, angelica, maekmundong, baekbokshin, baekchul, sansayuk, sanyak, longanyuk, wooseul, peony, jujube, omija, wonji, kill, It provides a composition for improving muscle tics and depression, characterized in that it contains a herbal mixture mixed with licorice and cinnamon.
또한, 산조인, 천마, 백잠감, 감국, 구기자, 길경, 당귀, 맥문동, 백복신, 백출, 산사육, 산약, 용안육, 우슬, 작약, 대추, 오미자, 원지, 죽여, 감초 및 계피는 각각 0.01 ~ 99.80중량%로 혼합되는 것을 특징으로 한다.In addition, Sanjoin, Cheonma, Baekjamgam, Gamguk, Gugija, Gilgyeong, Angelica, Maekmundong, Baekbokshin, Baekchul, Sansayuk, Sanyak, Longanyuk, Wooseul, Peony, Jujube, Omija, Wonji, Killer, Licorice and Cinnamon are 0.01 to 99.80 weight each. It is characterized in that it is mixed in %.
또한, 상기 생약재혼합물을 추출하고 농축한 생약재농축액과, 상기 생약재혼합물을 건조 분쇄한 생약재분말을 서로 혼합한 것을 특징으로 한다.In addition, it is characterized in that the herbal medicine concentrate obtained by extracting and concentrating the herbal medicine mixture, and the herbal medicine powder obtained by drying and pulverizing the herbal medicine mixture are mixed with each other.
또한, 본 발명은 산조인, 천마, 백잠감, 감국, 구기자, 길경, 당귀, 맥문동, 백복신, 백출, 산사육, 산약, 용안육, 우슬, 작약, 대추, 오미자, 원지, 죽여, 감초 및 계피를 혼합하여 생약재혼합물을 제조하고, 생약재혼합물로부터 생약재추출물을 추출하는 추출 단계(S10); 상기 추출 단계(S10)에서 추출된 생약재추출물을 농축하여, 생약재농축액을 제조하는 농축 단계(S20); 산조인, 천마, 백잠감, 감국, 구기자, 길경, 당귀, 맥문동, 백복신, 백출, 산사육, 산약, 용안육, 우슬, 작약, 대추, 오미자, 원지, 죽여, 감초 및 계피를 혼합하여 생약재혼합물을 제조하고, 건조 분쇄하여, 생약재분말을 제조하는 생약재분말 제조 단계(S30); 및 상기 농축 단계(S20)에서 제조된 생약재농축액과 상기 생약재분말 제조 단계(S30)에서 제조된 생약제 분말을 혼합하여 시럽을 제조하는 시럽 제조단계(S41)를 포함하는 것을 특징으로 하는 근육틱 및 우울증 개선용 조성물의 제조방법을 제공한다.In addition, the present invention is a mixture of sanjoin, cheonma, baekjamgam, gamguk, gugija, gilgyeong, angelica, maekmundong, baekbokshin, baekchul, sansayuk, sanyak, longanyuk, wooseul, peony, jujube, omija, raw paper, kill off, licorice and cinnamon. An extraction step (S10) of preparing a herbal medicine mixture and extracting a herbal medicine extract from the herbal medicine mixture; Concentrating the herbal medicine extract extracted in the extraction step (S10) to prepare a herbal medicine concentrate (S20); Sanjoin, Cheonma, Baekjamgam, Gamguk, Goji, Gilgyeong, Angelica, Maekmundong, Baekbokshin, Baekchul, Sansayuk, Sanyak, Longanyuk, Wooseul, Peony, Jujube, Omija, Wonji, Killer, Licorice and Cinnamon are mixed to produce a herbal medicine mixture. , by dry pulverizing, herbal medicine powder manufacturing step (S30) to prepare a herbal medicine powder; and a syrup preparation step (S41) of preparing a syrup by mixing the herbal medicine concentrate prepared in the concentration step (S20) and the herbal medicine powder prepared in the herbal medicine powder preparation step (S30) (S41). A method for preparing a composition for improvement is provided.
또한, 본 발명은 산조인, 천마, 백잠감, 감국, 구기자, 길경, 당귀, 맥문동, 백복신, 백출, 산사육, 산약, 용안육, 우슬, 작약, 대추, 오미자, 원지, 죽여, 감초 및 계피를 혼합하여 생약재혼합물을 제조하고, 생약재혼합물로부터 생약재추출물을 추출하는 추출 단계(S10); 상기 추출 단계(S10)에서 추출된 생약재추출물을 농축하여, 생약재농축액을 제조하는 농축 단계(S20); 산조인, 천마, 백잠감, 감국, 구기자, 길경, 당귀, 맥문동, 백복신, 백출, 산사육, 산약, 용안육, 우슬, 작약, 대추, 오미자, 원지, 죽여, 감초 및 계피를 혼합하여 생약재혼합물을 제조하고, 건조 분쇄하여, 생약재분말을 제조하는 생약재분말 제조 단계(S30); 및, 상기 농축 단계(S20)에서 제조된 생약재농축액과 상기 생약재분말 제조 단계(S30)에서 제조된 생약제 분말을 혼합하여 과립제, 산제 또는, 환제로 제조하는 약제 제조단계(S42)를 포함하는 것을 특징으로 하는 근육틱 및 우울증 개선용 조성물의 제조방법을 제공한다.In addition, the present invention is a mixture of sanjoin, cheonma, baekjamgam, gamguk, gugija, gilgyeong, angelica, maekmundong, baekbokshin, baekchul, sansayuk, sanyak, longanyuk, wooseul, peony, jujube, omija, raw paper, kill off, licorice and cinnamon. An extraction step (S10) of preparing a herbal medicine mixture and extracting a herbal medicine extract from the herbal medicine mixture; Concentrating the herbal medicine extract extracted in the extraction step (S10) to prepare a herbal medicine concentrate (S20); Sanjoin, Cheonma, Baekjamgam, Gamguk, Goji, Gilgyeong, Angelica, Maekmundong, Baekbokshin, Baekchul, Sansayuk, Sanyak, Longanyuk, Wooseul, Peony, Jujube, Omija, Wonji, Killer, Licorice and Cinnamon are mixed to produce a herbal medicine mixture. , by dry pulverizing, herbal medicine powder manufacturing step (S30) to prepare a herbal medicine powder; and, mixing the herbal medicine concentrate prepared in the concentration step (S20) and the herbal medicine powder prepared in the herbal medicine powder preparation step (S30) to prepare granules, powders, or pills (S42) characterized by comprising: It provides a method for preparing a composition for improving muscle tics and depression.
본 발명에 따른 근육틱 및 우울증 개선용 조성물 및 그 제조방법은 산조인, 천마, 백잠감, 감국, 구기자, 길경, 당귀, 맥문동, 백복신, 백출, 산사육, 산약, 용안육, 우슬, 작약, 대추, 오미자, 원지, 죽여, 감초 및 계피를 혼합한 생약재혼합물을 포함하여 근육틱 및 우울증 개선 효과를 갖는다.The composition for improving muscle tics and depression according to the present invention and its manufacturing method are sanjoin, cheonma, baekjamgam, gamguk, goji, gilgyeong, angelica, maekmundong, baekbokshin, baekchul, sansayuk, sanyak, longanyuk, wooseul, peony, jujube, omija , ginseng, porridge, licorice and cinnamon mixed with herbal medicine mixture, which has the effect of improving muscle tics and depression.
도 1은 본 발명에 따른 근육틱 및 우울증 개선용 조성물의 제조공정을 나타낸 플로우차트다.1 is a flowchart showing a manufacturing process of a composition for improving muscle tics and depression according to the present invention.
이하의 본 발명에 관한 상세한 설명들은 본 발명이 실시될 수 있는 실시 예이고 해당 실시 예의 예시로써 도시된 첨부 도면을 참조한다. 이들 실시 예는 당 업자가 본 발명의 실시에 충분하도록 상세히 설명된다. 본 발명의 다양한 실시 예는 서로 다르지만 상호 배타적일 필요는 없음이 이해되어야 한다. 예를 들어, 여기에 기재되어 있는 특정 형상, 구조 및 특성은 일 실시 예에 관련하여 본 발명의 사상 및 범위를 벗어나지 않으면서 다른 실시 예로 구현될 수 있다. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS The following detailed description of the present invention is an embodiment in which the present invention may be practiced, and reference is made to the accompanying drawings shown by way of example of the embodiment. These embodiments are described in sufficient detail to enable those skilled in the art to practice the present invention. It should be understood that various embodiments of the present invention are different but need not be mutually exclusive. For example, certain shapes, structures, and characteristics described herein may be implemented in other embodiments without departing from the spirit and scope of the invention in relation to one embodiment.
또한, 각각의 기재된 실시 예 내의 개별 구성요소의 위치 또는 배치는 본 발명의 사상 및 범위를 벗어나지 않으면서 변경될 수 있음이 이해되어야 한다.In addition, it should be understood that the position or arrangement of individual components in each described embodiment may be changed without departing from the spirit and scope of the present invention.
따라서 후술되는 상세한 설명은 한정적인 의미로서 취하려는 것이 아니며, 본 발명의 범위는 적절하게 설명된다면 그 청구항들이 주장하는 것과 균등한 모든 범위와 더불어 첨부된 청구항에 의해서만 한정된다. Accordingly, the detailed description set forth below is not intended to be taken in a limiting sense, and the scope of the present invention, if properly described, is limited only by the appended claims, along with all scopes equivalent to those claimed by the claims.
도면에서 유사한 참조부호는 여러 측면에 걸쳐서 동일하거나 유사한 기능을 지칭한다.Like reference numerals in the drawings refer to the same or similar functions throughout the various aspects.
본 발명에서 사용되는 용어는 본 발명에서의 기능을 고려하면서 가능한 현재 널리 사용되는 일반적인 용어들을 선택하였으나, 이는 당 분야에 종사하는 기술자의 의도 또는 판례, 새로운 기술의 출현 등에 따라 달라질 수 있다. The terms used in the present invention have been selected as currently widely used general terms as possible while considering the functions in the present invention, but these may vary depending on the intention or precedent of a person skilled in the art, the emergence of new technology, and the like.
또한, 특정한 경우는 출원인이 임의로 선정한 용어도 있으며, 이 경우 해당되는 발명의 설명 부분에서 상세히 그 의미를 기재할 것이다. In addition, in a specific case, there is a term arbitrarily selected by the applicant, and in this case, the meaning will be described in detail in the description of the corresponding invention.
따라서 본 발명에서 사용되는 용어는 단순한 용어의 명칭이 아닌, 그 용어가 가지는 의미와 본 발명의 전반에 걸친 내용을 토대로 정의되어야 한다.Therefore, the term used in the present invention should be defined based on the meaning of the term and the overall content of the present invention, rather than the name of a simple term.
본 발명에서 어떤 부분이 어떤 구성요소를 “포함”한다고 할 때, 이는 특별히 반대되는 기재가 없는 한, 다른 구성요소를 제외하는 것이 아니라 다른 구성요소를 더 포함할 수 있음을 의미한다.In the present invention, when a part “includes” a certain component, it means that other components may be further included, rather than excluding other components, unless otherwise stated.
이하, 본 발명에 따른 근육틱 및 우울증 개선용 조성물 및 그 제조방법에 대하여 자세히 설명한다.Hereinafter, a composition for improving muscle tics and depression and a method for manufacturing the same according to the present invention will be described in detail.
본 발명은 산조인, 천마, 백잠감, 감국, 구기자, 길경, 당귀, 맥문동, 백복신, 백출, 산사육, 산약, 용안육, 우슬, 작약, 대추, 오미자, 원지, 죽여, 감초 및 계피를 혼합한 생약재혼합물을 포함하는 것을 특징으로 하는 근육틱 및 우울증 개선용 조성물을 제공한다.The present invention is a herbal medicine mixture mixed with sanjoin, cheonma, baekjamgam, chrysanthemum, gugija, gilgyeong, angelica, maekmundong, baekbokshin, baekchul, sansayuk, sanyak, longanyuk, woosul, peony, jujube, omija, raw paper, kill off, licorice and cinnamon It provides a composition for improving muscle tics and depression, comprising:
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이때, 산조인, 천마, 백잠감, 감국, 구기자, 길경, 당귀, 맥문동, 백복신, 백출, 산사육, 산약, 용안육, 우슬, 작약, 대추, 오미자, 원지, 죽여, 감초 및 계피는 각각 0.01 ~ 99.80중량%로 혼합되는 것이 적절하다.At this time, Sanjoin, Cheonma, Baekjamgam, Gamguk, Gugija, Gilgyeong, Angelica, Maekmundong, Baekbokshin, Baekchul, Sansayuk, Sanyak, Longanyuk, Wooseul, Peony, Jujube, Omija, Wonji, Killer, Licorice and Cinnamon each weigh 0.01 ~ 99.80 weight. It is appropriate to mix in %.
구체적으로, 본 발명에 따른 생약재혼합물은, 산조인 0.01 ~ 99.80중량%, 천마 0.01 ~ 99.80중량%, 백잠감 0.01 ~ 99.80중량%, 감국 0.01 ~ 99.80중량%, 구기자 0.01 ~ 99.80중량%, 길경 0.01 ~ 99.80중량%, 당귀 0.01 ~ 99.80중량%, 맥문동 0.01 ~ 99.80중량%, 백복신 0.01 ~ 99.80중량%, 백출 0.01 ~ 99.80중량%, 산사육 0.01 ~ 99.80중량%, 산약 0.01 ~ 99.80중량%, 용안육 0.01 ~ 99.80중량%, 우슬 0.01 ~ 99.80중량%, 작약 0.01 ~ 99.80중량%, 대추 0.01 ~ 99.80중량%, 오미자 0.01 ~ 99.80중량%, 원지 0.01 ~ 99.80중량%, 죽여 0.01 ~ 99.80중량%, 감초 0.01 ~ 99.80중량% 및 계피 0.01 ~ 99.80중량%를 포함하는 것일 수 있다. Specifically, the herbal medicine mixture according to the present invention, Sanjoin 0.01 ~ 99.80% by weight, Chunma 0.01 ~ 99.80% by weight, Baekjamgam 0.01 ~ 99.80% by weight, Gamguk 0.01 ~ 99.80% by weight, Goji berry 0.01 ~ 99.80% by weight, Gilgyeong 0.01 ~ 99.80% by weight, Angelica 0.01 ~ 99.80% by weight, Maekmundong 0.01 ~ 99.80% by weight, Baekbokshin 0.01 ~ 99.80% by weight, Baekchul 0.01 ~ 99.80% by weight, Mountain breeding 0.01 ~ 99.80% by weight, Sanyak 0.01 ~ 99.80% by weight, Longan meat 0.01 ~ 99.80 wt%, hyssop 0.01 ~ 99.80% by weight, peony 0.01 ~ 99.80% by weight, jujube 0.01 ~ 99.80% by weight, omija 0.01 ~ 99.80% by weight, raw paper 0.01 ~ 99.80% by weight, porridge 0.01 ~ 99.80% by weight, licorice 0.01 ~ 99.80 weight % and 0.01 to 99.80% by weight of cinnamon may be included.
보다 자세하게, 상기 생약재혼합물은 총 중량대비 산조인 1.0 내지 10.0 중량%, 천마 1.0 내지 8.0 중량%, 백잠감 1.0 내지 7.0 중량%, 감국 1.0 내지 15.0 중량%, 구기자 1.0 내지 15.0 중량%, 길경 1.0 내지 15.0 중량%, 당귀 1.0 내지 15.0 중량%, 맥문동 1.0 내지 15.0 중량%, 백복신 1.0 내지 10.0중량%, 백출 1.0 내지 10.0 중량%, 산사육 1.0 내지 10.0 중량%, 산약 1.0 내지 10.0 중량%, 용안육 1.0 내지 8.0 중량%, 우슬 1.0 내지 8.0 중량%, 작약 1.0 내지 8.0 중량%, 대추 1.0 내지 7.0 중량%, 오미자 1.0 내지 7.0 중량%, 원지 1.0 내지 7.0 중량%, 죽여 1.0 내지 7.0 중량%, 감초 1.0 내지 5.0 중량% 및 계피 1.0 내지 5.0 중량%로 이루어지는 것일 수 있다.In more detail, the herbal medicine mixture is sanjoin 1.0 to 10.0 wt%, cheonma 1.0 to 8.0 wt%, baekjamgam 1.0 to 7.0 wt%, chrysanthemum 1.0 to 15.0 wt%, gugija 1.0 to 15.0 wt%, gilgyeong 1.0 to 15.0 wt% relative to the total weight Weight %, Angelica 1.0 to 15.0 wt%, Maekmundong 1.0 to 15.0 wt%, Baekbokshin 1.0 to 10.0 wt%, Baekchul 1.0 to 10.0 wt%, Mountain Sausage 1.0 to 10.0 wt%, Sanyak 1.0 to 10.0 wt%, Longan Meat 1.0 to 8.0 wt% %, hyssop 1.0 to 8.0% by weight, peony 1.0 to 8.0% by weight, jujube 1.0 to 7.0% by weight, omija 1.0 to 7.0% by weight, raw paper 1.0 to 7.0% by weight, bamboo shoot 1.0 to 7.0% by weight, licorice 1.0 to 5.0% by weight and 1.0 to 5.0% by weight of cinnamon.
한편, 본 발명에 따른 근육틱 및 우울증 개선용 조성물은 상기 생약재혼합물을 추출하고 농축한 생약재농축액과, 상기 생약재혼합물을 건조 분쇄한 생약재분말을 서로 혼합한 것일 수 있다. On the other hand, the composition for improving muscle tics and depression according to the present invention may be a mixture of a herbal medicine concentrate extracted and concentrated of the herbal medicine mixture, and a herbal medicine powder obtained by drying and pulverizing the herbal medicine mixture.
이에, 본 발명에 따른 근육틱 및 우울증 개선용 조성물은 산조인, 천마, 백잠감, 감국, 구기자, 길경, 당귀, 맥문동, 백복신, 백출, 산사육, 산약, 용안육, 우슬, 작약, 대추, 오미자, 원지, 죽여, 감초 및 계피를 혼합한 생약재혼합물을 추출하고, 농축한, 생약재농축액과; 산조인, 천마, 백잠감, 감국, 구기자, 길경, 당귀, 맥문동, 백복신, 백출, 산사육, 산약, 용안육, 우슬, 작약, 대추, 오미자, 원지, 죽여, 감초 및 계피를 혼합한 생약재혼합물을 건조하고 분쇄한 생약재 분말을 혼합한 것일 수 있다. 이때, 상기 생약재농축액과 생약재분말은 각각 0.1 ~ 99.9 : 0.1 ~ 99.9의 중량비로 혼합되는 것일 수 있다. 또한, 생약재농축액과 생약재분말의 혼합 중량비에 따라, 생약재농축액의 함량을 높이면, 시럽이 될 수도 있고, 생약재분말의 함량을 높이면 과립제, 산제 또는 환제가 될 수도 있다.Therefore, the composition for improving muscle tics and depression according to the present invention is sanjoin, cheonma, baekjamgam, gamguk, gugija, gilgyeong, angelica, maekmundong, baekbokshin, baekchul, sansayuk, sanyak, longanyuk, wooseul, peony, jujube, omija, and Wonji , kill, extract and concentrate a herbal medicine mixture mixed with licorice and cinnamon, and a herbal medicine concentrate; Sanjoin, Cheonma, Baekjamgam, Gamguk, Goji, Gilgyeong, Angelica, Maekmundong, Baekbokshin, Baekchul, Sansayuk, Sanyak, Longanyuk, Wooseul, Peony, Jujube, Omija, Wonji, Killer, Licorice and Cinnamon are dried. It may be a mixture of pulverized herbal powder. In this case, the herbal medicine concentrate and the herbal medicine powder may be mixed in a weight ratio of 0.1 to 99.9: 0.1 to 99.9, respectively. In addition, depending on the mixing weight ratio of the herbal medicine concentrate and the herbal medicine powder, if the content of the herbal medicine concentrate is increased, it may be syrup, and if the content of the herbal medicine powder is increased, it may be granules, powders or pills.
또한, 본 발명은 근육틱 및 우울증 개선용 조성물의 제조방법을 제공한다.In addition, the present invention provides a method for preparing a composition for improving muscle tics and depression.
근육틱 및 우울증 개선용 조성물의 제조방법은 산조인, 천마, 백잠감, 감국, 구기자, 길경, 당귀, 맥문동, 백복신, 백출, 산사육, 산약, 용안육, 우슬, 작약, 대추, 오미자, 원지, 죽여, 감초 및 계피를 혼합하여 생약재혼합물을 제조하고, 생약재혼합물로부터 생약재추출물을 추출하는 추출 단계(S10); 상기 추출 단계(S10)에서 추출된 생약재추출물을 농축하여, 생약재농축액을 제조하는 농축 단계(S20); 산조인, 천마, 백잠감, 감국, 구기자, 길경, 당귀, 맥문동, 백복신, 백출, 산사육, 산약, 용안육, 우슬, 작약, 대추, 오미자, 원지, 죽여, 감초 및 계피를 혼합하여 생약재혼합물을 제조하고, 건조 분쇄하여, 생약재분말을 제조하는 생약재분말 제조 단계(S30); 및 상기 농축 단계(S20)에서 제조된 생약재농축액과 상기 생약재분말 제조 단계(S30)에서 제조된 생약제 분말을 혼합하여 시럽을 제조하는 시럽 제조단계(S41)를 포함할 수 있다.The manufacturing method of the composition for improving muscle tics and depression is sanjoin, cheonma, baekjamgam, gamguk, gugija, gilgyeong, angelica, maekmundong, baekbokshin, baekchul, sansayuk, sanyak, longanyuk, wooseul, peony, jujube, omija, wonji, kill, An extraction step of preparing a herbal mixture by mixing licorice and cinnamon, and extracting a herbal extract from the herbal mixture (S10); Concentrating the herbal medicine extract extracted in the extraction step (S10) to prepare a herbal medicine concentrate (S20); Sanjoin, Cheonma, Baekjamgam, Gamguk, Goji, Gilgyeong, Angelica, Maekmundong, Baekbokshin, Baekchul, Sansayuk, Sanyak, Longanyuk, Wooseul, Peony, Jujube, Omija, Wonji, Killer, Licorice and Cinnamon are mixed to produce a herbal medicine mixture. , by dry pulverizing, herbal medicine powder manufacturing step (S30) to prepare a herbal medicine powder; and a syrup preparation step (S41) of preparing a syrup by mixing the herbal medicine concentrate prepared in the concentration step (S20) and the herbal medicine powder prepared in the herbal medicine powder preparation step (S30).
우선, 추출 단계(S10)를 수행한다.First, the extraction step (S10) is performed.
상기 추출 단계(S10)에서는 산조인, 천마, 백잠감, 감국, 구기자, 길경, 당귀, 맥문동, 백복신, 백출, 산사육, 산약, 용안육, 우슬, 작약, 대추, 오미자, 원지, 죽여, 감초 및 계피를 세척하고 혼합하여 생약재혼합물을 제조하고, 생약재혼합물로부터 생약재추출물을 추출한다.In the extraction step (S10), sanjoin, cheonma, baekjamgam, gamguk, goji, gilgyeong, angelica, maekmundong, baekbokshin, baekchul, sansayuk, sanyak, longanyuk, wooseul, peony, jujube, omija, raw paper, kill off, licorice and cinnamon A herbal medicine mixture is prepared by washing and mixing, and a herbal medicine extract is extracted from the herbal medicine mixture.
상기 추출 단계(S10)에서의 생약재혼합물은 산조인, 천마, 백잠감, 감국, 구기자, 길경, 당귀, 맥문동, 백복신, 백출, 산사육, 산약, 용안육, 우슬, 작약, 대추, 오미자, 원지, 죽여, 감초 및 계피가 각각 0.01 ~ 99.80중량%로 혼합된 것이 바람직하다. The herbal medicine mixture in the extraction step (S10) is sanjoin, cheonma, baekjamgam, gamguk, gugija, gilgyeong, angelica, maekmundong, baekbokshin, baekchul, sansayuk, sanyak, longanyuk, wooseul, peony, jujube, omija, raw paper, kill, It is preferable that licorice and cinnamon are mixed in an amount of 0.01 to 99.80% by weight, respectively.
더 구체적으로, 상기 추출 단계(S10)에서의 생약재혼합물은 총 중량대비 산조인 1.0 내지 10.0 중량%, 천마 1.0 내지 8.0 중량%, 백잠감 1.0 내지 7.0 중량%, 감국 1.0 내지 15.0 중량%, 구기자 1.0 내지 15.0 중량%, 길경 1.0 내지 15.0 중량%, 당귀 1.0 내지 15.0 중량%, 맥문동 1.0 내지 15.0 중량%, 백복신 1.0 내지 10.0중량%, 백출 1.0 내지 10.0 중량%, 산사육 1.0 내지 10.0 중량%, 산약 1.0 내지 10.0 중량%, 용안육 1.0 내지 8.0 중량%, 우슬 1.0 내지 8.0 중량%, 작약 1.0 내지 8.0 중량%, 대추 1.0 내지 7.0 중량%, 오미자 1.0 내지 7.0 중량%, 원지 1.0 내지 7.0 중량%, 죽여 1.0 내지 7.0 중량%, 감초 1.0 내지 5.0 중량% 및 계피 1.0 내지 5.0 중량%로 이루어지는 것일 수 있다.More specifically, the herbal medicine mixture in the extraction step (S10) is 1.0 to 10.0% by weight of sanjoin, 1.0 to 8.0% by weight of cheonma, 1.0 to 7.0% by weight of baekjamgam, 1.0 to 15.0% by weight of chrysanthemum, 1.0 to 15.0% by weight of gugija, relative to the total weight. 15.0 wt%, Gilgyeong 1.0 to 15.0 wt%, Angelica 1.0 to 15.0 wt%, Maekmundong 1.0 to 15.0 wt%, Baekboksin 1.0 to 10.0 wt%, Baekchul 1.0 to 10.0 wt%, Sansayuk 1.0 to 10.0 wt%, Sanyak 1.0 to 10.0 wt%, longan meat 1.0 to 8.0 wt%, hyssop 1.0 to 8.0 wt%, peony 1.0 to 8.0 wt%, jujube 1.0 to 7.0 wt%, omija 1.0 to 7.0 wt%, raw paper 1.0 to 7.0 wt%, porridge 1.0 to 7.0 wt% %, licorice 1.0 to 5.0% by weight, and cinnamon may be composed of 1.0 to 5.0% by weight.
상기 추출 단계(S10)에서는 생약재혼합물을 1,500 내지 3,000 mL의 추출 용매에 넣고, 70 내지 85 ℃의 온도로 5 내지 10 시간 동안 진공상태에서 생약재 추출물을 추출하는것이 바람직하다.In the extraction step (S10), it is preferable to put the herbal medicine mixture in 1,500 to 3,000 mL of an extraction solvent, and extract the herbal extract in a vacuum at a temperature of 70 to 85° C. for 5 to 10 hours.
상기 추출 단계(S10)에서의 추출용매는 정제수와 식품용 알코올을 2 : 8 내지 4 : 6 중량비로 혼합한 추출 용매를 이용한다. 상기 식품용 알코올은 에탄올인 것이 바람직하다. 상기 추출 용매는 알코올 대비 정제수의 중량비가 2 중량비 미만이면, 알코올 성분이 상대적으로 늘어나, 추출 후 남은 알코올을 제거하기 위한 공정이 추가되며, 알코올 대비 정제수의 중량비가 4 중량비 초과이면, 알코올 성분이 상대적으로 줄어 각각의 생약재에서 추출물들이 균일하게 추출되지 않는 문제점이 있다.As the extraction solvent in the extraction step (S10), an extraction solvent obtained by mixing purified water and food alcohol in a weight ratio of 2:8 to 4:6 is used. The food alcohol is preferably ethanol. In the extraction solvent, when the weight ratio of purified water to alcohol is less than 2 weight ratio, the alcohol component is relatively increased, a process for removing the alcohol remaining after extraction is added, and when the weight ratio of alcohol to purified water exceeds 4 weight ratio, the alcohol component is relatively There is a problem in that extracts are not uniformly extracted from each herbal medicine.
추출 단계(S10)는 생약재혼합물을 선옥균액에 침지하여 선옥균액에 침지된 생약재혼합물로부터 생약재추출물을 제조하는 침지추출단계(S15)로 진행될 수도 있다.The extraction step (S10) may proceed to an immersion extraction step (S15) of immersing the herbal medicine mixture in the seonok bacterium liquid to prepare a herbal medicine extract from the herbal medicine mixture immersed in the seonok bacterium liquid.
상기 침지추출단계(S15)에서는 산조인 1.0 내지 10.0 중량%, 천마 1.0 내지 8.0 중량%, 백잠감 1.0 내지 7.0 중량%, 감국 1.0 내지 15.0 중량%, 구기자 1.0 내지 15.0 중량%, 길경 1.0 내지 15.0 중량%, 당귀 1.0 내지 15.0 중량%, 맥문동 1.0 내지 15.0 중량%, 백복신 1.0 내지 10.0중량%, 백출 1.0 내지 10.0 중량%, 산사육 1.0 내지 10.0 중량%, 산약 1.0 내지 10.0 중량%, 용안육 1.0 내지 8.0 중량%, 우슬 1.0 내지 8.0 중량%, 작약 1.0 내지 8.0 중량%, 대추 1.0 내지 7.0 중량%, 오미자 1.0 내지 7.0 중량%, 원지 1.0 내지 7.0 중량%, 죽여 1.0 내지 7.0 중량%, 감초 1.0 내지 5.0 중량% 및 계피 1.0 내지 5.0 중량% 생약재혼합물을, 1,500 내지 3,000mL의 선옥균액에 넣어 12 내지 36 시간 동안 침지하고, 1,500 내지 3,000 mL의 추출 용매에 넣고, 70 내지 85 ℃의 온도로 5 내지 10 시간 동안 진공상태에서생약재혼합물로부터 생약재추출물을 추출한다. 상기 선옥균액은 선옥균과 정제수를 1 : 20 내지 1 : 30 중량비로 혼합한 것을 지칭하며, 선옥균은 시중에 판매되는 이엠생명과학연구원의 선옥발효수를 사용할 수 있다. In the immersion extraction step (S15), sanjoin 1.0 to 10.0 wt%, cheonma 1.0 to 8.0 wt%, baekjamgam 1.0 to 7.0 wt%, gamguk 1.0 to 15.0 wt%, gugija 1.0 to 15.0 wt%, gilgyeong 1.0 to 15.0 wt% , Angelica 1.0 to 15.0% by weight, Maekmundong 1.0 to 15.0% by weight, Baekboksin 1.0 to 10.0% by weight, Baekchul 1.0 to 10.0% by weight, Mountain breeding 1.0 to 10.0% by weight, Sanyak 1.0 to 10.0% by weight, Longanyuk 1.0 to 8.0% by weight, hyssop 1.0 to 8.0% by weight, peony 1.0 to 8.0% by weight, jujube 1.0 to 7.0% by weight, omija 1.0 to 7.0% by weight, raw paper 1.0 to 7.0% by weight, porridge 1.0 to 7.0% by weight, licorice 1.0 to 5.0% by weight and cinnamon 1.0 to 5.0% by weight of the herbal medicine mixture, placed in 1,500 to 3,000 mL of seonok bacteria solution, immersed for 12 to 36 hours, placed in 1,500 to 3,000 mL of extraction solvent, and vacuum at a temperature of 70 to 85 ° C. for 5 to 10 hours Extracts herbal extracts from herbal mixtures in The seonok bacterium liquid refers to a mixture of seonok bacterium and purified water in a weight ratio of 1: 20 to 1: 30, and for seonok bacterium, commercially available seonok fermented water of EM Life Science Research Institute may be used.
상기 선옥균은 발효음식인 김치, 간장, 고추장, 된장, 청국장, 젓갈 등에서 추출한 유익한 발효미생물인 유산균, 효모균, 납두균, 아세트산균 등을 통칭하는 말로서, 인체에 유익한 균들 중 서로 공존공생하는 균 집단을 말한다. 인체에 유익한 균들은 공존공생하면서 유기물을 분해하고 항산화물질을 생성하여 건강에 도움을 준다. 인간의 장에는 선옥균, 악옥균, 중간균이 공존하는데, 중간균이 장내 세균 중에서 가장 많은 비율을 차지하고 있다. 중간균은 선옥균과 악옥균 중 세력이 우세한 균에 따라 작용하며, 악옥균이 우세하게 되면 선옥균의 작용이 부족하여 독소 제거 기능과 장의 면역기능이 떨어지게 된다.The Seonokgyun is a collective term for lactic acid bacteria, yeast bacteria, naphdubacteriaceae, and acetic acid bacteria, which are beneficial fermented microorganisms extracted from fermented foods such as kimchi, soy sauce, gochujang, soybean paste, cheonggukjang, and salted fish, and refers to a group of bacteria that coexist with each other among beneficial bacteria . Bacteria beneficial to the human body coexist and decompose organic matter and produce antioxidants to help health. Good bacteria, bad bacteria, and intermediate bacteria coexist in the human intestine, and intermediate bacteria account for the largest proportion of intestinal bacteria. The intermediate bacteria act according to the dominant bacteria among the good bacteria and the bad bacteria, and when the bad bacteria prevail, the function of the good bacteria is insufficient, and the toxin removal function and the immune function of the intestine are deteriorated.
다음으로, 농축 단계(S20)를 수행한다.Next, a concentration step (S20) is performed.
상기 농축 단계(S20)에서는 상기 추출 단계(S10) 또는 침지추출단계(S15)에서 추출된 생약재추출물을 농축하여, 생약재농축액을 제조한다. In the concentration step (S20), the herbal medicine extract extracted in the extraction step (S10) or the immersion extraction step (S15) is concentrated to prepare a herbal medicine concentrate.
상기 농축 단계(S20)에서는 3,000 내지 6,000 mL의 생약재추출물을 진공 저온 농축 방법으로 600 내지 1,200 mL의 생약재 농축액을 제조한다. 상기 진공 저온 농축 방법은 열 또는 공기에 영향을 받아 산화되기 쉬운 물질을 농축하는 방법으로, 진공상태에서 저온 40 내지 80℃에서 한다.In the concentration step (S20), 3,000 to 6,000 mL of herbal medicine extract is prepared by vacuum low temperature concentration method to prepare 600 to 1,200 mL of herbal medicine concentrate. The vacuum low temperature concentration method is a method of concentrating a material that is easily oxidized under the influence of heat or air, and is performed at a low temperature of 40 to 80° C. in a vacuum state.
다음으로, 생약재분말 제조 단계(S30)를 수행한다.Next, the herbal medicine powder manufacturing step (S30) is performed.
상기 생약재분말 제조 단계(S30)에서는 산조인, 천마, 백잠감, 감국, 구기자, 길경, 당귀, 맥문동, 백복신, 백출, 산사육, 산약, 용안육, 우슬, 작약, 대추, 오미자, 원지, 죽여, 감초 및 계피를 혼합하여 생약재혼합물을 제조하고, 건조 분쇄하여, 생약재분말을 제조한다.In the herbal medicine powder manufacturing step (S30), sanjoin, cheonma, baekjamgam, gamguk, gugija, gilgyeong, angelica, maekmundong, baekbokshin, baekchul, sansayuk, sanyak, longanyuk, wooseul, peony, jujube, omija, raw paper, kill, licorice and A herbal medicine mixture is prepared by mixing cinnamon, and dried and pulverized to prepare a herbal medicine powder.
상기 생약재분말 제조 단계(S30)에서의 생약재혼합물은 산조인, 천마, 백잠감, 감국, 구기자, 길경, 당귀, 맥문동, 백복신, 백출, 산사육, 산약, 용안육, 우슬, 작약, 대추, 오미자, 원지, 죽여, 감초 및 계피가 각각 0.01 ~ 99.80중량%로 혼합된 것이 바람직하다. 더 구체적으로, 상기 생약재분말 제조 단계(S30)에서의 생약재혼합물은 총 중량대비 산조인 1.0 내지 10.0 중량%, 천마 1.0 내지 8.0 중량%, 백잠감 1.0 내지 7.0 중량%, 감국 1.0 내지 15.0 중량%, 구기자 1.0 내지 15.0 중량%, 길경 1.0 내지 15.0 중량%, 당귀 1.0 내지 15.0 중량%, 맥문동 1.0 내지 15.0 중량%, 백복신 1.0 내지 10.0중량%, 백출 1.0 내지 10.0 중량%, 산사육 1.0 내지 10.0 중량%, 산약 1.0 내지 10.0 중량%, 용안육 1.0 내지 8.0 중량%, 우슬 1.0 내지 8.0 중량%, 작약 1.0 내지 8.0 중량%, 대추 1.0 내지 7.0 중량%, 오미자 1.0 내지 7.0 중량%, 원지 1.0 내지 7.0 중량%, 죽여 1.0 내지 7.0 중량%, 감초 1.0 내지 5.0 중량% 및 계피 1.0 내지 5.0 중량%로 이루어지는 것일 수 있다.The herbal medicine mixture in the herbal medicine powder manufacturing step (S30) is sanjoin, cheonma, baekjamgam, gamguk, gugija, gilgyeong, angelica, maekmundong, baekbokshin, baekchul, sansayuk, sanyak, longanyuk, wooseul, peony, jujube, omija, wonji, It is preferable that porridge, licorice and cinnamon are mixed in an amount of 0.01 to 99.80% by weight, respectively. More specifically, the herbal medicine mixture in the herbal powder manufacturing step (S30) is 1.0 to 10.0% by weight of sanjoin, 1.0 to 8.0% by weight of cheonma, 1.0 to 7.0% by weight of baekjamgam, 1.0 to 15.0% by weight of gamguk, gugija, based on the total weight. 1.0 to 15.0 wt%, Gilgyeong 1.0 to 15.0 wt%, Angelica 1.0 to 15.0 wt%, Maekmundong 1.0 to 15.0 wt%, Baekboksin 1.0 to 10.0 wt%, Baekchul 1.0 to 10.0 wt%, Sansayuk 1.0 to 10.0 wt%, Sanyak 1.0 to 10.0 wt%, longan meat 1.0 to 8.0 wt%, hyssop 1.0 to 8.0 wt%, peony 1.0 to 8.0 wt%, jujube 1.0 to 7.0 wt%, omija 1.0 to 7.0 wt%, raw paper 1.0 to 7.0 wt%, porridge 1.0 to It may be composed of 7.0% by weight, 1.0 to 5.0% by weight of licorice, and 1.0 to 5.0% by weight of cinnamon.
상기 생약재분말 제조 단계(S30)에서는 상기 생약재 혼합물을 세척하여 배합한 후, 건조기에서 50 내지 65 ℃의 온도, 10 내지 12 시간 동안 건조한 후, 80 내지 150 mesh의 생약재분말을 제조한다.In the herbal medicine powder manufacturing step (S30), the herbal medicine mixture is washed and blended, dried in a dryer at a temperature of 50 to 65 ° C. for 10 to 12 hours, and then the herbal medicine powder of 80 to 150 mesh is prepared.
다음으로, 시럽 제조단계(S41)를 수행한다.Next, the syrup preparation step (S41) is performed.
상기 시럽 제조단계(S41)에서는 상기 농축 단계(S20)에서 제조된 생약재농축액과 상기 생약재분말 제조 단계(S30)에서 제조된 생약제 분말을 혼합하여 시럽을 제조한다.In the syrup preparation step (S41), the herbal medicine concentrate prepared in the concentration step (S20) and the herbal medicine powder prepared in the herbal medicine powder preparation step (S30) are mixed to prepare a syrup.
이때, 상기 시럽 제조 단계(S41)에서 상기 생약재농축액과 생약재분말은 각각 0.1 ~ 99.9 : 1의 중량비로 혼합되는 것일 수 있다. 보다 구체적으로, 상기 시럽 제조 단계(S41)에서 상기 생약재농축액과 생약재분말은 4 : 1 ~ 20 : 1의 중량비로 혼합될 수 있을 것이다.In this case, in the syrup preparation step (S41), the herbal medicine concentrate and the herbal medicine powder may be mixed in a weight ratio of 0.1 to 99.9:1, respectively. More specifically, in the syrup preparation step (S41), the herbal medicine concentrate and the herbal medicine powder may be mixed in a weight ratio of 4:1 to 20:1.
또는, 본 발명에 따른 근육틱 및 우울증 개선용 조성물의 제조방법은 시럽 제조단계(S41) 대신 약제 제조단계(S42)를 수행할 수도 있을 것이다. 상기 시럽 제조단계(S41)와 약제 제조단계(S42)는 생약재농축액과 생약재분말의 혼합 중량비를 달리한 것으로, 생약재농축액의 함량이 상대적으로 높으면 시럽이되며, 생약재분말의 함량이 상대적으로 높으면 과립제, 산제 또는, 환제가 될 수 있다.Alternatively, in the method for preparing the composition for improving muscle tics and depression according to the present invention, the drug preparation step (S42) may be performed instead of the syrup preparation step (S41). The syrup manufacturing step (S41) and the drug manufacturing step (S42) have different mixing weight ratios of the herbal medicine concentrate and the herbal medicine powder, and when the content of the herbal medicine concentrate is relatively high, it becomes a syrup, and when the content of the herbal medicine powder is relatively high, it becomes a granule; It may be a powder or a pill.
상기 약제 제조단계(S42)에서는 상기 생약재농축액과 생약재분말을 1 : 1 내지 3 : 1 중량비로 배합한 후 동결 건조로 과립제를 제조한다. 상기 생약재농축액이 생약재분말 대비 1 중량비 미만이면 생약재분말의 중량비가 상대적으로 높아 생약재농축액의 근육 경련 및 우울증 개선의 효능이 나타나지 않으며, 생약재분말 대비 3 중량비 초과이면 생약재 농축액과 생약재분말이 뭉쳐지지 않는다.In the pharmaceutical preparation step (S42), the herbal medicine concentrate and the herbal medicine powder are mixed in a weight ratio of 1:1 to 3:1 and then freeze-drying to prepare granules. If the herbal concentrate is less than 1 weight ratio compared to the herbal powder, the weight ratio of the herbal powder is relatively high, so the efficacy of improving muscle spasms and depression of the herbal concentrate does not appear.
상기 약제 제조단계(S42)에서는 생약재농축액과 생약재분말을 1 : 1 내지 3 : 1 중량비로 혼합하여 50 내지 65 ℃의 온도로 10 내지 12시간 동안 건조한 후, 80 내지 150 mesh의 산제를 제조한다.In the pharmaceutical preparation step (S42), the herbal medicine concentrate and the herbal medicine powder are mixed in a weight ratio of 1:1 to 3: 1, dried at a temperature of 50 to 65° C. for 10 to 12 hours, and then a powder of 80 to 150 mesh is prepared.
상기 약제 제조단계(S42)에서는 상기 산제 100 내지 300g에 찹쌀 50 내지 400g과 정제수 200 내지 800mL를 혼합하여 3 내지 5 mm의 직경으로 환제를 제조할 수도 있다.In the pharmaceutical preparation step (S42), 50 to 400 g of glutinous rice and 200 to 800 mL of purified water are mixed with 100 to 300 g of the powder to prepare a pill having a diameter of 3 to 5 mm.
이때, 근육틱 및 우울증 개선용 조성물의 제조방법은 산조인, 천마, 백잠감, 감국, 구기자, 길경, 당귀, 맥문동, 백복신, 백출, 산사육, 산약, 용안육, 우슬, 작약, 대추, 오미자, 원지, 죽여, 감초 및 계피를 혼합하여 생약재혼합물을 제조하고, 생약재혼합물로부터 생약재추출물을 추출하는 추출 단계(S10); 상기 추출 단계(S10)에서 추출된 생약재추출물을 농축하여, 생약재농축액을 제조하는 농축 단계(S20); 산조인, 천마, 백잠감, 감국, 구기자, 길경, 당귀, 맥문동, 백복신, 백출, 산사육, 산약, 용안육, 우슬, 작약, 대추, 오미자, 원지, 죽여, 감초 및 계피를 혼합하여 생약재혼합물을 제조하고, 건조 분쇄하여, 생약재분말을 제조하는 생약재분말 제조 단계(S30); 및, 상기 농축 단계(S20)에서 제조된 생약재농축액과 상기 생약재분말 제조 단계(S30)에서 제조된 생약제 분말을 혼합하여 과립제, 산제 또는, 환제로 제조하는 약제 제조단계(S42)를 포함할 수 있다.At this time, the manufacturing method of the composition for improving muscle tics and depression is sanjoin, cheonma, baekjamgam, gamguk, gugija, gilgyeong, angelica, maekmundong, baekbokshin, baekchul, sansayuk, sanyak, longanyuk, wooseul, peony, jujube, omija, Wonji, An extraction step (S10) of preparing a herbal medicine mixture by mixing kill, licorice and cinnamon, and extracting a herbal medicine extract from the herbal medicine mixture; Concentrating the herbal medicine extract extracted in the extraction step (S10) to prepare a herbal medicine concentrate (S20); Sanjoin, Cheonma, Baekjamgam, Gamguk, Goji, Gilgyeong, Angelica, Maekmundong, Baekbokshin, Baekchul, Sansayuk, Sanyak, Longanyuk, Wooseul, Peony, Jujube, Omija, Wonji, Killer, Licorice and Cinnamon are mixed to produce a herbal medicine mixture. , by dry pulverizing, herbal medicine powder manufacturing step (S30) to prepare a herbal medicine powder; And, mixing the herbal medicine concentrate prepared in the concentration step (S20) and the herbal medicine powder prepared in the herbal medicine powder preparation step (S30) to prepare granules, powders, or pills (S42) may include. .
상기, 추출 단계(S10), 농축 단계(S20), 생약재분말 제조 단계(S30)과, 시럽제조단계(S41) 또는 약제 제조단계(S42)를 수행하고 나면 본 발명에 따른 근육틱 및 우울증 개선용 조성물을 얻을 수 있을 것이다.After performing the extraction step (S10), the concentration step (S20), the herbal medicine powder production step (S30), the syrup production step (S41) or the drug production step (S42), for improving muscle tics and depression according to the present invention composition can be obtained.
이하, 하기 제조예, 실시예, 비교예 및 실험예를 통하여 본 발명에 따른 근육틱 및 우울증 개선용 조성물이 갖는 효과에 대하여 자세히 확인한다.Hereinafter, the effect of the composition for improving muscle tics and depression according to the present invention will be confirmed in detail through the following Preparation Examples, Examples, Comparative Examples and Experimental Examples.
제조예production example 1. One. 선옥균액의of seonok fungus 제조 Produce
정제수와 선옥균을 1 : 20 중량비로 혼합하여 선옥균액을 제조하였다.Purified water and Seonokbacterium were mixed in a weight ratio of 1:20 to prepare a Seonokbacterium solution.
제조예production example 2. 2. 추출용매의of the extraction solvent 제조 Produce
정제수와 에탄올을 3 : 7 중량비로 혼합하여 추출용매를 제조하였다.Purified water and ethanol were mixed in a 3:7 weight ratio to prepare an extraction solvent.
실시예Example 1. One. 근육틱muscle tic 및 우울증 개선용 시럽 조성물의 제조 and preparation of a syrup composition for improving depression
산조인, 천마, 백잠감, 감국, 구기자, 길경, 당귀, 맥문동, 백복신, 백출, 산사육, 산약, 용안육, 우슬, 작약, 대추, 오미자, 원지, 죽여, 감초 및 계피를 이용하여 실시예 1의 조성물을 제조하였다.Composition of Example 1 using sanjoin, cheonma, baekjamgam, gamguk, goji, gilgyeong, angelica, maekmundong, baekbokshin, baekchul, sansayuk, sanyak, longanyuk, wooseul, peony, jujube, omija, raw paper, kill off, licorice and cinnamon was prepared.
추출단계(S10): 산조인 5.0중량%, 천마 5.0중량%, 백잠감 4.0중량%, 감국 9.0중량%, 구기자 5.0중량%, 길경 5.0중량%, 당귀 5.0중량%, 맥문동 5.0중량%, 백복신 5.0중량%, 백출 5.0중량%, 산사육 5.0중량%, 산약 5.0중량%, 용안육 5.0중량%, 우슬 5.0중량%, 작약 5.0중량%, 대추 4.0중량%, 오미자 4.0중량%, 원지 4.0중량%, 죽여 4.0중량%, 감초 3.0중량% 및 계피 3.0중량%로 이루어진 생약재혼합물을 세척하고 혼합하여 생약재혼합물을 제조하고, 생약재혼합물에 제조예 2의 추출 용매를 2,000 mL를 넣고, 70 내지 75℃의 온도로 10시간 동안 진공상태에서 추출하여 생약재 추출물을 제조하였다.Extraction step (S10): sanjoin 5.0% by weight, cheonma 5.0% by weight, baekjamgam 4.0% by weight, chrysanthemum 9.0% by weight, gugija 5.0% by weight, gilgyeong 5.0% by weight, angelica 5.0% by weight, maekmundong 5.0% by weight, baekbokshin 5.0% by weight %, baekchul 5.0% by weight, mountain breeding 5.0% by weight, sanyak 5.0% by weight, longan meat 5.0% by weight, hyssop 5.0% by weight, peony 5.0% by weight, jujube 4.0% by weight, omija 4.0% by weight, raw paper 4.0% by weight, porridge 4.0% by weight %, licorice 3.0% by weight, and cinnamon 3.0% by weight to wash and mix to prepare a herbal mixture, and 2,000 mL of the extraction solvent of Preparation Example 2 to the herbal mixture, 70 to 75 ℃ temperature for 10 hours During the extraction in a vacuum state, herbal extracts were prepared.
농축 단계(S20): 상기 추출단계(S10)에서 얻은 생약재추출물 4000mL를 진공 저온 농축 방법으로 800 mL로 농축하여 생약재 농축액을 제조하였다.Concentration step (S20): 4000 mL of the herbal extract obtained in the extraction step (S10) was concentrated to 800 mL by vacuum low temperature concentration to prepare a herbal concentrate.
생약재분말 제조 단계(S30): 산조인 5.0중량%, 천마 5.0중량%, 백잠감 4.0중량%, 감국 9.0중량%, 구기자 5.0중량%, 길경 5.0중량%, 당귀 5.0중량%, 맥문동 5.0중량%, 백복신 5.0중량%, 백출 5.0중량%, 산사육 5.0중량%, 산약 5.0중량%, 용안육 5.0중량%, 우슬 5.0중량%, 작약 5.0중량%, 대추 4.0중량%, 오미자 4.0중량%, 원지 4.0중량%, 죽여 4.0중량%, 감초 3.0중량% 및 계피 3.0중량%로 이루어진 생약재혼합물을 세척하고 혼합하여 생약재혼합물을 제조하고, 건조기에서 60 내지 65℃의 온도로 10시간 동안 건조하고, 분쇄하여 100 mesh의 생약재 분말을 제조하였다.Herbal medicine powder manufacturing step (S30): sanjoin 5.0% by weight, cheonma 5.0% by weight, baekjamgam 4.0% by weight, gamguk 9.0% by weight, gugija 5.0% by weight, gilgyeong 5.0% by weight, angelica 5.0% by weight, maekmundong 5.0% by weight, baekbokshin 5.0% by weight, baekchul 5.0% by weight, mountain breeding 5.0% by weight, sanyak 5.0% by weight, longan meat 5.0% by weight, hyssop 5.0% by weight, peony 5.0% by weight, jujube 4.0% by weight, Schisandra 4.0% by weight, raw paper 4.0% by weight, porridge A herbal medicine mixture consisting of 4.0% by weight, 3.0% by weight of licorice and 3.0% by weight of cinnamon is washed and mixed to prepare a herbal mixture, dried in a dryer at a temperature of 60 to 65° C. for 10 hours, and pulverized to 100 mesh herbal powder was prepared.
시럽 제조단계(S41): 농축 단계(S20)에서 제조된 생약재농축액과 생약재분말 제조 단계(S30)에서 제조된 생약재분말을 4 : 1의 중량비로 혼합하여 시럽제를 제조하였다. Syrup preparation step (S41): The herbal medicine concentrate prepared in the concentration step (S20) and the herbal medicine powder prepared in the herbal medicine powder preparation step (S30) were mixed in a weight ratio of 4:1 to prepare a syrup.
실시예Example 2. 2. 근육틱muscle tic 및 우울증 개선용 and for improving depression 환제pill 제조 Produce
산조인, 천마, 백잠감, 감국, 구기자, 길경, 당귀, 맥문동, 백복신, 백출, 산사육, 산약, 용안육, 우슬, 작약, 대추, 오미자, 원지, 죽여, 감초 및 계피를 이용하여 실시예 2의 환제를 제조하였다.Pills of Example 2 using Sanjoin, Cheonma, Baekjamgam, Gamguk, Goji, Gilgyeong, Angelica, Maekmundong, Baekbokshin, Baekchul, Sansayuk, Sanyak, Longanyuk, Wooseul, Peony, Jujube, Omija, Wonji, Killer, Licorice and Cinnamon was prepared.
추출단계(S10): 산조인 5.0중량%, 천마 5.0중량%, 백잠감 4.0중량%, 감국 9.0중량%, 구기자 5.0중량%, 길경 5.0중량%, 당귀 5.0중량%, 맥문동 5.0중량%, 백복신 5.0중량%, 백출 5.0중량%, 산사육 5.0중량%, 산약 5.0중량%, 용안육 5.0중량%, 우슬 5.0중량%, 작약 5.0중량%, 대추 4.0중량%, 오미자 4.0중량%, 원지 4.0중량%, 죽여 4.0중량%, 감초 3.0중량% 및 계피 3.0중량%로 이루어진 생약재혼합물을 세척하고 혼합하여 생약재혼합물을 제조하고, 생약재혼합물에 제조예 2의 추출 용매를 2,000 mL를 넣고, 70 내지 75℃의 온도로 10시간 동안 진공상태에서 추출하여 생약재 추출물을 제조하였다.Extraction step (S10): sanjoin 5.0% by weight, cheonma 5.0% by weight, baekjamgam 4.0% by weight, chrysanthemum 9.0% by weight, gugija 5.0% by weight, gilgyeong 5.0% by weight, angelica 5.0% by weight, maekmundong 5.0% by weight, baekbokshin 5.0% by weight %, baekchul 5.0% by weight, mountain breeding 5.0% by weight, sanyak 5.0% by weight, longan meat 5.0% by weight, hyssop 5.0% by weight, peony 5.0% by weight, jujube 4.0% by weight, omija 4.0% by weight, raw paper 4.0% by weight, porridge 4.0% by weight %, licorice 3.0% by weight, and cinnamon 3.0% by weight to wash and mix to prepare a herbal mixture, and 2,000 mL of the extraction solvent of Preparation Example 2 to the herbal mixture, 70 to 75 ℃ temperature for 10 hours During the extraction in a vacuum state, herbal extracts were prepared.
농축 단계(S20): 상기 추출단계(S10)에서 얻은 생약재추출물 4000mL를 진공 저온 농축 방법으로 800 mL로 농축하여 생약재 농축액을 제조하였다.Concentration step (S20): 4000 mL of the herbal extract obtained in the extraction step (S10) was concentrated to 800 mL by vacuum low temperature concentration to prepare a herbal concentrate.
생약재분말 제조 단계(S30): 산조인 5.0중량%, 천마 5.0중량%, 백잠감 4.0중량%, 감국 9.0중량%, 구기자 5.0중량%, 길경 5.0중량%, 당귀 5.0중량%, 맥문동 5.0중량%, 백복신 5.0중량%, 백출 5.0중량%, 산사육 5.0중량%, 산약 5.0중량%, 용안육 5.0중량%, 우슬 5.0중량%, 작약 5.0중량%, 대추 4.0중량%, 오미자 4.0중량%, 원지 4.0중량%, 죽여 4.0중량%, 감초 3.0중량% 및 계피 3.0중량%로 이루어진 생약재혼합물을 세척하고 혼합하여 생약재혼합물을 제조하고, 건조기에서 60 내지 65℃의 온도로 10시간 동안 건조하고, 분쇄하여 100 mesh의 생약재 분말을 제조하였다.Herbal medicine powder manufacturing step (S30): sanjoin 5.0% by weight, cheonma 5.0% by weight, baekjamgam 4.0% by weight, gamguk 9.0% by weight, gugija 5.0% by weight, gilgyeong 5.0% by weight, angelica 5.0% by weight, maekmundong 5.0% by weight, baekbokshin 5.0% by weight, baekchul 5.0% by weight, mountain breeding 5.0% by weight, sanyak 5.0% by weight, longan meat 5.0% by weight, hyssop 5.0% by weight, peony 5.0% by weight, jujube 4.0% by weight, Schisandra 4.0% by weight, raw paper 4.0% by weight, porridge A herbal medicine mixture consisting of 4.0% by weight, 3.0% by weight of licorice and 3.0% by weight of cinnamon is washed and mixed to prepare a herbal mixture, dried in a dryer at a temperature of 60 to 65° C. for 10 hours, and pulverized to 100 mesh herbal powder was prepared.
환제 제조단계(S41): 농축 단계(S20)에서 제조된 생약재농축액과 생약재분말 제조 단계(S30)에서 제조된 생약재분말을 2 : 1의 중량비로 혼합하여 60 내지 65℃ 온도로 5시간 동안 건조하여 얻어진 100g을 찹쌀 100g과 정제수 200mL를 혼합하고 4mm의 직경으로 빚어 환제를 제조하였다.Pill preparation step (S41): The herbal medicine concentrate prepared in the concentration step (S20) and the herbal medicine powder prepared in the herbal medicine powder preparation step (S30) are mixed in a weight ratio of 2: 1 and dried at a temperature of 60 to 65 ° C. for 5 hours. The obtained 100g was mixed with 100g of glutinous rice and 200mL of purified water and molded to a diameter of 4mm to prepare a pill.
비교예comparative example 1. One. 산조인만only sanjoin 단독으로 포함하는 included alone 환제의of pills 제조 Produce
하기의 제조방법에 따라 산조인만을 단독으로 포함하는 환제조성물을 제조하였다.A pill composition containing only sanjoin alone was prepared according to the following manufacturing method.
추출단계(S10): 산조인을 세척하고 제조예 2의 추출 용매를 2,000 mL를 넣고, 70 내지 75℃의 온도로 10시간 동안 진공상태에서 추출하여 생약재 추출물을 제조하였다.Extraction step (S10): After washing sanjoin, 2,000 mL of the extraction solvent of Preparation Example 2 was added, and extracted in a vacuum at a temperature of 70 to 75° C. for 10 hours to prepare a herbal extract.
농축 단계(S20): 상기 추출단계(S10)에서 얻은 생약재추출물 4000mL를 진공 저온 농축 방법으로 800 mL로 농축하여 생약재 농축액을 제조하였다.Concentration step (S20): 4000 mL of the herbal extract obtained in the extraction step (S10) was concentrated to 800 mL by vacuum low temperature concentration to prepare a herbal concentrate.
생약재분말 제조 단계(S30): 산조인을 세척하고 건조기에서 60 내지 65℃의 온도로 10시간 동안 건조하고, 분쇄하여 100 mesh의 생약재 분말을 제조하였다.Herbal medicine powder preparation step (S30): Sanjoin was washed, dried in a dryer at a temperature of 60 to 65° C. for 10 hours, and pulverized to prepare 100 mesh herbal medicine powder.
환제 제조단계(S41): 농축 단계(S20)에서 제조된 생약재농축액과 생약재분말 제조 단계(S30)에서 제조된 생약재분말을 2 : 1의 중량비로 혼합하여 60 내지 65℃ 온도로 5시간 동안 건조하여 얻어진 100g을 찹쌀 100g과 정제수 200mL를 혼합하고 4mm의 직경으로 빚어 환제를 제조하였다.Pill preparation step (S41): The herbal medicine concentrate prepared in the concentration step (S20) and the herbal medicine powder prepared in the herbal medicine powder preparation step (S30) are mixed in a weight ratio of 2: 1 and dried at a temperature of 60 to 65 ° C. for 5 hours. The obtained 100g was mixed with 100g of glutinous rice and 200mL of purified water and molded to a diameter of 4mm to prepare a pill.
비교예comparative example 2 내지 21. 각각 천마, 2 to 21. Cheonma, respectively, 백잠감baekjamgam , , 감국chrysanthemum , 구기자, , wolfberry, 길경Gilkyung , 당귀, 맥문동, 백복신, 백출, , Angelica, Maekmun-dong, White Lucky God, Baekchul, 산사육mountain breeding , , 산약acid pill , , 용안육longan meat , , 우슬hyssop , 작약, 대추, 오미자, 원지, 죽여, 감초, 계피를 단독으로 포함하는 환제의 제조, Peony, jujube, omija, raw paper, porridge, licorice, manufacturing of pills containing cinnamon alone
비교예 1과 동일한 과정으로 수행하되, 산조인 대신 각각 천마(비교예2), 백잠감(비교예3), 감국(비교예4), 구기자(비교예5), 길경(비교예6), 당귀(비교예7), 맥문동(비교예8), 백복신(비교예9), 백출(비교예10), 산사육(비교예11), 산약(비교예12), 용안육(비교예13), 우슬(비교예14), 작약(비교예15), 대추(비교예16), 오미자(비교예17), 원지(비교예18), 죽여(비교예19), 감초(비교예20), 계피(비교예21)를 적용하여 비교예 2 내지 21의 환제를 제조하였다.Performed in the same manner as in Comparative Example 1, but instead of sanjoin, Cheonma (Comparative Example 2), Baekjamgam (Comparative Example 3), Gamguk (Comparative Example 4), Gugija (Comparative Example 5), Gilgyeong (Comparative Example 6), Angelica (Comparative Example 7), Maekmundong (Comparative Example 8), White Lucky God (Comparative Example 9), Baekchul (Comparative Example 10), Sansayuk (Comparative Example 11), Sanyak (Comparative Example 12), Longanyuk (Comparative Example 13), Wooseul ( Comparative example 14), peony (comparative example 15), jujube (comparative example 16), omija (comparative example 17), raw paper (comparative example 18), porridge (comparative example 19), licorice (comparative example 20), cinnamon (comparative example 20) Example 21) was applied to prepare the pills of Comparative Examples 2 to 21.
실시예Example 3. 3. 침지단계를immersion step 수행한 performed 근육틱muscle tic 및 우울증 개선용 조성물의 제조 and preparation of a composition for alleviating depression
산조인, 천마, 백잠감, 감국, 구기자, 길경, 당귀, 맥문동, 백복신, 백출, 산사육, 산약, 용안육, 우슬, 작약, 대추, 오미자, 원지, 죽여, 감초 및 계피를 이용하여 실시예 3의 환제를 제조하였다.Pills of Example 3 using Sanjoin, Cheonma, Baekjamgam, Gamguk, Goji, Gilgyeong, Angelica, Maekmundong, Baekbokshin, Baekchul, Sansayuk, Sanyak, Longanyuk, Wooseul, Peony, Jujube, Omija, Wonji, Killer, Licorice and Cinnamon was prepared.
침지추출단계(S15): 산조인 5.0중량%, 천마 5.0중량%, 백잠감 4.0중량%, 감국 9.0중량%, 구기자 5.0중량%, 길경 5.0중량%, 당귀 5.0중량%, 맥문동 5.0중량%, 백복신 5.0중량%, 백출 5.0중량%, 산사육 5.0중량%, 산약 5.0중량%, 용안육 5.0중량%, 우슬 5.0중량%, 작약 5.0중량%, 대추 4.0중량%, 오미자 4.0중량%, 원지 4.0중량%, 죽여 4.0중량%, 감초 3.0중량% 및 계피 3.0중량%로 이루어진 생약재혼합물을 세척하여 혼합하고, 제조예 1의 선옥균액 2,000 mL를 넣고 24 시간 동안 침지하여 제조한 생약재혼합물에, 제조예 2의 추출 용매를 2,000 mL를 넣고, 70 내지 75℃의 온도로 10시간 동안 진공상태에서 추출하여 생약재 추출물을 제조하였다.Immersion extraction step (S15): sanjoin 5.0% by weight, cheonma 5.0% by weight, baekjamgam 4.0% by weight, chrysanthemum 9.0% by weight, gugija 5.0% by weight, gilgyeong 5.0% by weight, angelica 5.0% by weight, maekmundong 5.0% by weight, baekbokshin 5.0 wt%, baekchul 5.0% by weight, mountain breed 5.0% by weight, sanyak 5.0% by weight, longan meat 5.0% by weight, hyssop 5.0% by weight, peony 5.0% by weight, jujube 4.0% by weight, omija 4.0% by weight, raw paper 4.0% by weight, porridge 4.0 In the herbal medicine mixture prepared by washing and mixing the herbal medicine mixture consisting of wt%, 3.0% by weight of licorice and 3.0% by weight of cinnamon, and adding 2,000 mL of Seonokbacterium solution of Preparation Example 1 and immersing for 24 hours, the extraction solvent of Preparation Example 2 was added. 2,000 mL was added, and extracted in a vacuum at a temperature of 70 to 75° C. for 10 hours to prepare a herbal extract.
농축 단계(S20): 상기 침지추출단계(S15)에서 얻은 생약재추출물 4000mL를 진공 저온 농축 방법으로 800 mL로 농축하여 생약재 농축액을 제조하였다.Concentration step (S20): 4000 mL of the herbal extract obtained in the immersion extraction step (S15) was concentrated to 800 mL using a vacuum low temperature concentration method to prepare a herbal concentrate.
생약재분말 제조 단계(S30): 산조인 5.0중량%, 천마 5.0중량%, 백잠감 4.0중량%, 감국 9.0중량%, 구기자 5.0중량%, 길경 5.0중량%, 당귀 5.0중량%, 맥문동 5.0중량%, 백복신 5.0중량%, 백출 5.0중량%, 산사육 5.0중량%, 산약 5.0중량%, 용안육 5.0중량%, 우슬 5.0중량%, 작약 5.0중량%, 대추 4.0중량%, 오미자 4.0중량%, 원지 4.0중량%, 죽여 4.0중량%, 감초 3.0중량% 및 계피 3.0중량%로 이루어진 생약재혼합물을 세척하고 혼합하여 생약재혼합물을 제조하고, 건조기에서 60 내지 65℃의 온도로 10시간 동안 건조하고, 분쇄하여 100 mesh의 생약재 분말을 제조하였다.Herbal medicine powder manufacturing step (S30): sanjoin 5.0% by weight, cheonma 5.0% by weight, baekjamgam 4.0% by weight, gamguk 9.0% by weight, gugija 5.0% by weight, gilgyeong 5.0% by weight, angelica 5.0% by weight, maekmundong 5.0% by weight, baekbokshin 5.0% by weight, baekchul 5.0% by weight, mountain breeding 5.0% by weight, sanyak 5.0% by weight, longan meat 5.0% by weight, hyssop 5.0% by weight, peony 5.0% by weight, jujube 4.0% by weight, Schisandra 4.0% by weight, raw paper 4.0% by weight, porridge A herbal medicine mixture consisting of 4.0% by weight, 3.0% by weight of licorice and 3.0% by weight of cinnamon is washed and mixed to prepare a herbal mixture, dried in a dryer at a temperature of 60 to 65° C. for 10 hours, and pulverized to 100 mesh herbal powder was prepared.
환제 제조단계(S41): 농축 단계(S20)에서 제조된 생약재농축액과 생약재분말 제조 단계(S30)에서 제조된 생약재분말을 2 : 1의 중량비로 혼합하여 60 내지 65℃ 온도로 5시간 동안 건조하여 얻어진 100g을 찹쌀 100g과 정제수 200mL를 포ㅎㄴ합하고 4mm의 직경으로 빚어 환제를 제조하였다.Pill preparation step (S41): The herbal medicine concentrate prepared in the concentration step (S20) and the herbal medicine powder prepared in the herbal medicine powder preparation step (S30) are mixed in a weight ratio of 2: 1 and dried at a temperature of 60 to 65 ° C. for 5 hours. The obtained 100g was mixed with 100g of glutinous rice and 200mL of purified water and molded to a diameter of 4mm to prepare a pill.
비교예comparative example 22. 일부 원물을 변경한 22. Some originals have been changed 환제pill 조성물의 제조 Preparation of the composition
하기의 제조방법에 따라 일부 원물을 변경하여 환제조성물을 제조하였다.A pill composition was prepared by changing some raw materials according to the following manufacturing method.
(A1) 감국 9 중량%, 구기자 5 중량%, 길경 5 중량%, 당귀 5 중량%, 맥문동 5 중량%, 더덕 5 중량%, 백복신 5 중량%, 백출 5 중량%, 산사육 5 중량%, 산약 5 중량%, 시호 5 중량%, 용안육 5 중량%, 우슬 5 중량%, 작약 5 중량%, 갈근 4 중량%, 대추 4 중량%, 오미자 4 중량%, 원지 4 중량%, 죽여 4 중량%, 감초 3 중량% 및 계피 3 중량%로 이루어진 생약재 혼합물을 세척하여 배합한 후, 상기 제조예 1의 선옥균액 2,000 mL를 넣고 24 시간 동안 침지하여 생약재 혼합물을 제조하였다.(A1) Chrysanthemum 9% by weight, Goji berry 5% by weight, Gilgyeong 5% by weight, Angelica 5% by weight, Maekmundong 5% by weight, Deodeok 5% by weight, Baekbokshin 5% by weight, Baekchul 5% by weight, Mountain sage 5% by weight, Sanyak 5 Weight %, Shiho 5% by weight, Longan meat 5% by weight, Urseul 5% by weight, Peony 5% by weight, Root 4% by weight, Jujube 4% by weight, Schisandra 4% by weight, Raw paper 4% by weight, Sashimi 4% by weight, Licorice 3 After washing and blending the herbal medicine mixture composed of 3% by weight and 3% by weight of cinnamon, 2,000 mL of the Seonokbacterium solution of Preparation Example 1 was added and immersed for 24 hours to prepare a herbal mixture.
(A2) 상기 단계(A1)의 선옥균에 침지된 생약재 혼합물을 상기 제조예 2의 추출 용매를 2,000 mL를 넣고, 70 내지 75 ℃의 온도로 10시간 동안 진공상태에서 생약재 추출물을 제조하였다.(A2) 2,000 mL of the extraction solvent of Preparation Example 2 was added to the herbal mixture immersed in Seonokbacterium in step (A1), and a herbal extract was prepared in a vacuum at a temperature of 70 to 75° C. for 10 hours.
(A3) 상기 단계(A2)에서 얻은 4,000 mL 생약재 추출물을 진공 저온 농축 방법으로 800 mL로 농축하여 생약재 농축액을 제조하였다.(A3) The 4,000 mL herbal extract obtained in step (A2) was concentrated to 800 mL by vacuum low temperature concentration to prepare a herbal concentrate.
(B1) 감국 9 중량%, 구기자 5 중량%, 길경 5 중량%, 당귀 5 중량%, 맥문동 5 중량%, 더덕 5 중량%, 백복신 5 중량%, 백출 5 중량%, 산사육 5 중량%, 산약 5 중량%, 시호 5 중량%, 용안육 5 중량%, 우슬 5 중량%, 작약 5 중량%, 갈근 4 중량%, 대추 4 중량%, 오미자 4 중량%, 원지 4 중량%, 죽여 4 중량%, 감초 3 중량% 및 계피 3 중량%로 이루어진 생약재 혼합물을 세척한 후, 건조기에서 60 내지 65 ℃의 온도, 10 시간 동안 건조한 후, 100 mesh의 생약재 분말을 제조하였다.(B1) Chrysanthemum 9% by weight, Goji berry 5% by weight, Gilgyeong 5% by weight, Angelica 5% by weight, Maekmundong 5% by weight, Deodeok 5% by weight, Baekbokshin 5% by weight, Baekchul 5% by weight, Sansayuk 5% by weight, Sanyak 5 Weight %, Shiho 5% by weight, Longan meat 5% by weight, Urseul 5% by weight, Peony 5% by weight, Root 4% by weight, Jujube 4% by weight, Schisandra 4% by weight, Raw paper 4% by weight, Sashimi 4% by weight, Licorice 3 After washing the herbal mixture consisting of 3% by weight and 3% by weight of cinnamon, and then drying at a temperature of 60 to 65 ℃ in a dryer for 10 hours, a 100 mesh herbal powder was prepared.
(B2) 상기 단계(A3)의 생약재 농축액과 옥수수 분말을 2 : 1 중량비로 혼합한 후, 동결건조하여 과립제를 제조하고, 상기 단계 (A3)의 생약재 농축액과 상기 단계(B1)의 생약재 분말을 2 : 1 중량비로 혼합하여 60 내지 65℃ 온도로 5 시간 동안 건조한 후 100 mesh의 산제를 제조하며, 상기 산제 100 g에 찹쌀 100 g과 정제수 200 mL를 혼합하여 4 mm의 직경으로 환제를 제조하였다.(B2) After mixing the herbal medicine concentrate of step (A3) and corn powder in a weight ratio of 2: 1, freeze-drying to prepare granules, and the herbal medicine concentrate of step (A3) and the herbal medicine powder of step (B1) After mixing in a 2: 1 weight ratio and drying at a temperature of 60 to 65° C. for 5 hours, a powder of 100 mesh was prepared, and 100 g of glutinous rice and 200 mL of purified water were mixed with 100 g of the powder to prepare a pill having a diameter of 4 mm. .
실험예Experimental example 1. One. 근육틱muscle tic 개선 효과 확인 Check the improvement effect
본 발명의 생약재 추출물을 유효성분으로 하는 근육틱 및 우울증 개선용 조성물의 근육틱 개선 효과를 확인하기 위하여, 평소에 근육틱 장애 증상을 가진 10~30대 남녀 200명을 대상자로 선정하였다. 대상자 200명을 각 100명씩, 시험군 1 및 2로 나누었다.In order to confirm the improvement effect of the composition for improving muscle tics and depression using the herbal extract of the present invention as an active ingredient, 200 men and women in their 10s and 30s with symptoms of muscle tic disorder were selected as subjects. 200 subjects were divided into test groups 1 and 2, 100 subjects each.
시험군 1은 실시예 및 비교예에서 제조된 시럽 및 환제를 섭취하도록 하였으며, 시럽의 경우에는 1회 50mL, 1일 3회, 4주(28일) 동안 섭취하도록 하였고, 환제의 경우에는 1회 10알씩, 1일 3회, 4주(28일) 동안 섭취하도록 하였다. Test group 1 was allowed to ingest the syrup and pills prepared in Examples and Comparative Examples, and in the case of syrup, 50 mL once, 3 times a day, for 4 weeks (28 days), and once in the case of pills 10 tablets, 3 times a day, for 4 weeks (28 days) was to be taken.
시험군 2은 실시예 및 비교예에서 제조된 시럽 및 환제를 섭취하도록 하였으며, 시럽의 경우에는 1회 100mL, 1일 3회, 4주(28일) 동안 섭취하도록 하였고, 환제는 1회 20알씩, 1일 3회, 4주(28일) 동안 섭취하도록 하였다.Test group 2 was allowed to ingest the syrup and pills prepared in Examples and Comparative Examples, and in the case of syrup, 100 mL at a time, 3 times a day, for 4 weeks (28 days), 20 pills at a time , 3 times a day, for 4 weeks (28 days).
근육틱이 하루에 발생하는 빈도를 구하여 평균값을 계산하여 하기 표 1에 나타내었다. The frequency of occurrence of muscle tics per day was calculated, and the average value was calculated and shown in Table 1 below.
실험예Experimental example 2. 수면장애 개선효과 확인 2. Confirmation of sleep disorder improvement effect
본 발명의 생약재 추출물을 유효성분으로 하는 근육틱 및 우울증 개선용 조성물의 수면장애 개선 효과를 확인하기 위하여, 평소에 수면장애 증상을 가진 10~30대 남녀 200명을 대상자로 선정하였다. 대상자 200명을 각 100명씩, 시험군 1 및 2로 나누었다.In order to confirm the sleep disorder improvement effect of the composition for improving muscle tics and depression containing the herbal extract of the present invention as an active ingredient, 200 men and women in their 10s and 30s with usual sleep disorder symptoms were selected as subjects. 200 subjects were divided into test groups 1 and 2, 100 subjects each.
시험군 1은 실시예 및 비교예에서 제조된 시럽 및 환제를 섭취하도록 하였으며, 시럽의 경우에는 1회 50mL, 1일 3회, 4주(28일) 동안 섭취하도록 하였고, 환제의 경우에는 1회 10알씩, 1일 3회, 4주(28일) 동안 섭취하도록 하였다. Test group 1 was allowed to ingest the syrup and pills prepared in Examples and Comparative Examples, and in the case of syrup, 50 mL once, 3 times a day, for 4 weeks (28 days), and once in the case of pills 10 tablets, 3 times a day, for 4 weeks (28 days) was to be taken.
시험군 2은 실시예 및 비교예에서 제조된 시럽 및 환제를 섭취하도록 하였으며, 시럽의 경우에는 1회 100mL, 1일 3회, 4주(28일) 동안 섭취하도록 하였고, 환제는 1회 20알씩, 1일 3회, 4주(28일) 동안 섭취하도록 하였다.Test group 2 was allowed to ingest the syrup and pills prepared in Examples and Comparative Examples, and in the case of syrup, 100 mL at a time, 3 times a day, for 4 weeks (28 days), 20 pills at a time , 3 times a day, for 4 weeks (28 days).
수면장애의 개선정도는 실시예에서 제조된 시럽 및 환을 섭취하기 전의 증상을 5점 기준으로 하여 평가하였으며(5점: 변화없음, 4점:약간 개선, 3점, 다소 개선, 2점: 상당히 개선, 1점 완전 개선), 그 평균값을 하기 표 2에 나타내었다.The degree of improvement of sleep disturbance was evaluated on the basis of 5 points of the symptoms before ingesting the syrup and pills prepared in Examples (5 points: no change, 4 points: slightly improved, 3 points, slightly improved, 2 points: significantly improvement, 1 point complete improvement), the average value is shown in Table 2 below.
실험예Experimental example 3. 우울감 개선효과 확인 3. Confirmation of Depression Improvement Effect
본 발명의 생약재 추출물을 유효성분으로 하는 근육틱 및 우울증 개선용 조성물의 우울감 개선 효과를 확인하기 위하여, 평소에 우울감 증상을 가진 10~30대 남녀 200명을 대상자로 선정하였다. 대상자 200명을 각 100명씩, 시험군 1 및 2로 나누었다.In order to confirm the depressive effect of the composition for improving muscle tics and depression using the herbal extract of the present invention as an active ingredient, 200 men and women in their 10s and 30s who usually have depressive symptoms were selected as subjects. 200 subjects were divided into test groups 1 and 2, 100 subjects each.
시험군 1은 실시예 및 비교예에서 제조된 시럽 및 환제를 섭취하도록 하였으며, 시럽의 경우에는 1회 50mL, 1일 3회, 4주(28일) 동안 섭취하도록 하였고, 환제의 경우에는 1회 10알씩, 1일 3회, 4주(28일) 동안 섭취하도록 하였다. Test group 1 was allowed to ingest the syrup and pills prepared in Examples and Comparative Examples, and in the case of syrup, 50 mL once, 3 times a day, for 4 weeks (28 days), and once in the case of pills 10 tablets, 3 times a day, for 4 weeks (28 days) was to be taken.
시험군 2은 실시예 및 비교예에서 제조된 시럽 및 환제를 섭취하도록 하였으며, 시럽의 경우에는 1회 100mL, 1일 3회, 4주(28일) 동안 섭취하도록 하였고, 환제는 1회 20알씩, 1일 3회, 4주(28일) 동안 섭취하도록 하였다.Test group 2 was allowed to ingest the syrup and pills prepared in Examples and Comparative Examples, and in the case of syrup, 100 mL at a time, 3 times a day, for 4 weeks (28 days), 20 pills at a time , 3 times a day, for 4 weeks (28 days).
우울감의 개선정도는 실시예에서 제조된 환을 섭취하기 전의 증상을 5점 기준(5점: 변화없음, 4점:약간 개선, 3점, 다소 개선, 2점: 상당히 개선, 1점 완전 개선)으로 하여 평가하였으며, 그 평균값을 하기 표 3에 나타내었다.The degree of improvement in depression is based on the symptoms before ingestion of the pills prepared in the Examples by 5 points (5 points: no change, 4 points: slightly improved, 3 points, slightly improved, 2 points: significantly improved, 1 point completely improved) was evaluated, and the average value is shown in Table 3 below.
실험예Experimental example 4. 우울증 개선의 효과 확인 4. Confirm the effect of improving depression
본 발명의 생약재 추출물을 유효성분으로 하는 근육틱 및 우울증 개선용 조성물의 우울증 개선 효과를 확인하기 위하여, 평소에 우울증상을 가진 40대 남녀 100명에 대하여 실시예 및 비교예에서 제조된 시럽 및 환제를 섭취하도록 하였으며, 시럽의 경우에는 1회 50mL, 1일 3회, 4주(28일) 동안 섭취하도록 하였고, 환제의 경우에는 1회 10알씩, 1일 3회, 4주(28일) 동안 섭취하도록 하였다. 개선 정도는 실시예에서 제조된 환을 섭취하기 전의 우울 증상을 5점 기준으로 하여 평가하였으며(5점: 변화없음, 4점: 약간 개선, 3점: 다소 개선, 2점: 상당히 개선, 1점: 완전 개선), 그 평균값을 하기 표 4에 나타내었다.Syrup and pills prepared in Examples and Comparative Examples for 100 men and women in their 40s who usually had depressive symptoms in order to confirm the antidepressant effect of the composition for improving muscle tics and depression containing the herbal extract of the present invention as an active ingredient In the case of syrup, 50 mL at a time, 3 times a day, for 4 weeks (28 days), and in the case of pills, 10 tablets at a time, 3 times a day, for 4 weeks (28 days) was made to be ingested. The degree of improvement was evaluated on the basis of 5 points of depressive symptoms before ingesting the pills prepared in Examples (5 points: no change, 4 points: slightly improved, 3 points: slightly improved, 2 points: significantly improved, 1 point) : complete improvement), and the average value is shown in Table 4 below.
결론. conclusion.
상기 실시예 비교예 및 실험예를 통해 확인한 바와 같이, 본 발명에 따른 조성물은 근육틱 및 우울증 개선에 효과가 있음을 확인할 수 있었다.As confirmed through the Comparative Examples and Experimental Examples, it was confirmed that the composition according to the present invention is effective in improving muscle tics and depression.
실험예 1 내지 4를 통하여, 본 발명에 따른 근육틱 및 우울증 개선용 조성물은 근육틱 개선, 수면장애, 우울감 개선, 우울증 개선 효과를 가짐을 확인할 수 있었으며, 개별적인 구성성분에 비해, 이들이 조합되었을 때 시너지 효과가 나타나는 것을 확인할 수 있었으며, 이들의 조합에 따라 예기치 못한 효과가 나타났음을 확인할 수 있었다.Through Experimental Examples 1 to 4, it was confirmed that the composition for improving muscle tics and depression according to the present invention had the effect of improving muscle tic, sleep disorder, depression, and depression, and compared to individual components, when they were combined It could be confirmed that a synergistic effect appeared, and it was confirmed that an unexpected effect appeared according to the combination thereof.
또한, 종래의 감국, 구기자, 길경, 당귀, 맥문동, 더덕, 백복신, 백출, 산사육, 산약, 시호, 용안육, 우슬, 작약, 갈근, 대추, 오미자, 원지, 죽여, 감초 및 계피를 포함하는 근육틱 및 우울증 개선용 조성물에 비해, 진보된 월등한 효과가 나타났음을 확인할 수 있었다.In addition, the conventional gamguk, goji berry, gilgyeong, angelica, maekmundong, deodeok, baekbokshin, baekchul, sansayuk, sanyak, shiho, longanyuk, wooseul, peony, galgeun, jujube, omija, raw ji, kill, licorice and cinnamon And compared to the composition for improving depression, it was confirmed that an advanced superior effect appeared.
따라서, 본 발명은 산조인, 천마, 백잠감, 감국, 구기자, 길경, 당귀, 맥문동, 백복신, 백출, 산사육, 산약, 용안육, 우슬, 작약, 대추, 오미자, 원지, 죽여, 감초 및 계피를 혼합한 생약재혼합물을 포함하여 근육틱, 수면장애, 우울감 및 우울증 개선효과를 갖는 근육틱 및 우울증 개선용 조성물을 개발하였음을 명시한다.Therefore, the present invention is a mixture of sanjoin, cheonma, baekjamgam, gamguk, gugija, gilgyeong, angelica, maekmundong, baekbokshin, baekchul, sansayuk, sanyak, longanyuk, woosul, peony, jujube, omija, raw paper, kill off, licorice and cinnamon. It specifies that a composition for improving muscle tics and depression has been developed, including herbal medicine mixtures, which have the effect of improving muscle tics, sleep disorders, depression, and depression.
본 발명을 첨부된 도면과 함께 설명하였으나, 이는 본 발명의 요지를 포함하는 다양한 실시 형태 중의 하나의 실시 예에 불과하며, 당 업계에서 통상의 지식을 가진 자가 용이하게 실시할 수 있도록 하는 데에 그 목적이 있는 것으로, 본 발명은 상기 설명된 실시예에만 국한되는 것이 아님은 명확하다. 따라서, 본 발명의 보호범위는 하기의 청구범위에 의해 해석되어야 하며, 본 발명의 요지를 벗어나지 않는 범위 내에서 변경, 치환, 대체 등에 의해 그와 동등한 범위 내에 있는 모든 기술 사상은 본 발명의 권리에 포함될 것이다. 또한, 도면의 일부 구성은 구성을 보다 명확하게 설명하기 위한 것으로 실제보다 과장되거나 축소되어 제공되는 것임을 명확히 한다.Although the present invention has been described with the accompanying drawings, this is only one embodiment of various embodiments including the gist of the present invention, and is intended to be easily implemented by those of ordinary skill in the art. For the purpose, it is clear that the present invention is not limited to the embodiments described above. Accordingly, the protection scope of the present invention should be construed by the following claims, and all technical ideas within the equivalent range by changes, substitutions, substitutions, etc. within the scope not departing from the gist of the present invention are in the right of the present invention. will be included In addition, it is clarified that some components of the drawings are provided in an exaggerated or reduced form than in reality to more clearly describe the configuration.
(S10): 추출 단계
(S15): 침지추출단계
(S20): 농축 단계
(S30): 생약재 분말 제조 단계
(S41): 시럽 제조단계
(S42): 약제 제조단계(S10): extraction step
(S15): immersion extraction step
(S20): Concentration step
(S30): herbal medicine powder manufacturing step
(S41): syrup manufacturing step
(S42): drug manufacturing step
Claims (5)
Sanjoin 1.0 to 10.0 wt%, Cheonma 1.0 to 8.0 wt%, Baekjamgam 1.0 to 7.0 wt%, Gamguk 1.0 to 15.0 wt%, Gugija 1.0 to 15.0 wt%, Gilgyeong 1.0 to 15.0 wt%, Angelica 1.0 to 15.0 wt%, Maekmundong 1.0 to 15.0% by weight, Baekbokshin 1.0 to 10.0% by weight, Baekchul 1.0 to 10.0% by weight, Mountain breeding 1.0 to 10.0% by weight, Sanyak 1.0 to 10.0% by weight, Longan meat 1.0 to 8.0% by weight, Wooseul 1.0 to 8.0% by weight, Peony 1.0 to 8.0% by weight, jujube 1.0 to 7.0% by weight, 1.0 to 7.0% by weight of omija, 1.0 to 7.0% by weight of raw paper, 1.0 to 7.0% by weight of porridge, 1.0 to 5.0% by weight of licorice, and 1.0 to 5.0% by weight of cinnamon A composition for improving muscle tics and depression, characterized in that it contains a herbal medicine mixture.
상기 생약재혼합물을 추출하고 농축한 생약재농축액과, 상기 생약재혼합물을 건조 분쇄한 생약재분말을 서로 혼합한 것을 특징으로 하는 근육틱 및 우울증 개선용 조성물.
According to claim 1,
A composition for improving muscle tics and depression, characterized in that the herbal medicine concentrate extracted and concentrated of the herbal medicine mixture and the herbal medicine powder obtained by drying and pulverizing the herbal medicine mixture are mixed with each other.
상기 추출 단계(S10)에서 추출된 생약재추출물을 농축하여, 생약재농축액을 제조하는 농축 단계(S20);
산조인 1.0 내지 10.0 중량%, 천마 1.0 내지 8.0 중량%, 백잠감 1.0 내지 7.0 중량%, 감국 1.0 내지 15.0 중량%, 구기자 1.0 내지 15.0 중량%, 길경 1.0 내지 15.0 중량%, 당귀 1.0 내지 15.0 중량%, 맥문동 1.0 내지 15.0 중량%, 백복신 1.0 내지 10.0중량%, 백출 1.0 내지 10.0 중량%, 산사육 1.0 내지 10.0 중량%, 산약 1.0 내지 10.0 중량%, 용안육 1.0 내지 8.0 중량%, 우슬 1.0 내지 8.0 중량%, 작약 1.0 내지 8.0 중량%, 대추 1.0 내지 7.0 중량%, 오미자 1.0 내지 7.0 중량%, 원지 1.0 내지 7.0 중량%, 죽여 1.0 내지 7.0 중량%, 감초 1.0 내지 5.0 중량% 및 계피 1.0 내지 5.0 중량%를 혼합하여 생약재혼합물을 제조하고, 건조 분쇄하여, 생약재분말을 제조하는 생약재분말 제조 단계(S30); 및
상기 농축 단계(S20)에서 제조된 생약재농축액과 상기 생약재분말 제조 단계(S30)에서 제조된 생약제 분말을 혼합하여 시럽을 제조하는 시럽 제조단계(S41)를 포함하는 것을 특징으로 하는 근육틱 및 우울증 개선용 조성물의 제조방법.
Sanjoin 1.0 to 10.0 wt%, Cheonma 1.0 to 8.0 wt%, Baekjamgam 1.0 to 7.0 wt%, Gamguk 1.0 to 15.0 wt%, Gugija 1.0 to 15.0 wt%, Gilgyeong 1.0 to 15.0 wt%, Angelica 1.0 to 15.0 wt%, Maekmundong 1.0 to 15.0% by weight, Baekbokshin 1.0 to 10.0% by weight, Baekchul 1.0 to 10.0% by weight, Mountain breeding 1.0 to 10.0% by weight, Sanyak 1.0 to 10.0% by weight, Longan meat 1.0 to 8.0% by weight, Wooseul 1.0 to 8.0% by weight, Peony 1.0 to 8.0% by weight, jujube 1.0 to 7.0% by weight, 1.0 to 7.0% by weight of omija, 1.0 to 7.0% by weight of raw paper, 1.0 to 7.0% by weight of porridge, 1.0 to 5.0% by weight of licorice, and 1.0 to 5.0% by weight of cinnamon An extraction step (S10) of preparing a herbal medicine mixture and extracting a herbal medicine extract from the herbal medicine mixture;
Concentrating the herbal medicine extract extracted in the extraction step (S10) to prepare a herbal medicine concentrate (S20);
Sanjoin 1.0 to 10.0 wt%, Cheonma 1.0 to 8.0 wt%, Baekjamgam 1.0 to 7.0 wt%, Gamguk 1.0 to 15.0 wt%, Gugija 1.0 to 15.0 wt%, Gilgyeong 1.0 to 15.0 wt%, Angelica 1.0 to 15.0 wt%, Maekmundong 1.0 to 15.0% by weight, Baekbokshin 1.0 to 10.0% by weight, Baekchul 1.0 to 10.0% by weight, Mountain breeding 1.0 to 10.0% by weight, Sanyak 1.0 to 10.0% by weight, Longan meat 1.0 to 8.0% by weight, Wooseul 1.0 to 8.0% by weight, Peony 1.0 to 8.0% by weight, jujube 1.0 to 7.0% by weight, 1.0 to 7.0% by weight of omija, 1.0 to 7.0% by weight of raw paper, 1.0 to 7.0% by weight of porridge, 1.0 to 5.0% by weight of licorice, and 1.0 to 5.0% by weight of cinnamon A herbal medicine powder manufacturing step (S30) of preparing a herbal medicine mixture, drying and pulverizing, to prepare a herbal medicine powder; and
Improvement of muscle tics and depression, characterized in that it comprises a syrup preparation step (S41) of preparing a syrup by mixing the herbal medicine concentrate prepared in the concentration step (S20) and the herbal medicine powder prepared in the herbal medicine powder production step (S30) A method for preparing a composition.
상기 추출 단계(S10)에서 추출된 생약재추출물을 농축하여, 생약재농축액을 제조하는 농축 단계(S20);
산조인 1.0 내지 10.0 중량%, 천마 1.0 내지 8.0 중량%, 백잠감 1.0 내지 7.0 중량%, 감국 1.0 내지 15.0 중량%, 구기자 1.0 내지 15.0 중량%, 길경 1.0 내지 15.0 중량%, 당귀 1.0 내지 15.0 중량%, 맥문동 1.0 내지 15.0 중량%, 백복신 1.0 내지 10.0중량%, 백출 1.0 내지 10.0 중량%, 산사육 1.0 내지 10.0 중량%, 산약 1.0 내지 10.0 중량%, 용안육 1.0 내지 8.0 중량%, 우슬 1.0 내지 8.0 중량%, 작약 1.0 내지 8.0 중량%, 대추 1.0 내지 7.0 중량%, 오미자 1.0 내지 7.0 중량%, 원지 1.0 내지 7.0 중량%, 죽여 1.0 내지 7.0 중량%, 감초 1.0 내지 5.0 중량% 및 계피 1.0 내지 5.0 중량%를 혼합하여 생약재혼합물을 제조하고, 건조 분쇄하여, 생약재분말을 제조하는 생약재분말 제조 단계(S30); 및,
상기 농축 단계(S20)에서 제조된 생약재농축액과 상기 생약재분말 제조 단계(S30)에서 제조된 생약제 분말을 혼합하여 과립제, 산제 또는, 환제로 제조하는 약제 제조단계(S42)를 포함하는 것을 특징으로 하는 근육틱 및 우울증 개선용 조성물의 제조방법.
Sanjoin 1.0 to 10.0 wt%, Cheonma 1.0 to 8.0 wt%, Baekjamgam 1.0 to 7.0 wt%, Gamguk 1.0 to 15.0 wt%, Gugija 1.0 to 15.0 wt%, Gilgyeong 1.0 to 15.0 wt%, Angelica 1.0 to 15.0 wt%, Maekmundong 1.0 to 15.0% by weight, Baekbokshin 1.0 to 10.0% by weight, Baekchul 1.0 to 10.0% by weight, Mountain breeding 1.0 to 10.0% by weight, Sanyak 1.0 to 10.0% by weight, Longan meat 1.0 to 8.0% by weight, Wooseul 1.0 to 8.0% by weight, Peony 1.0 to 8.0% by weight, jujube 1.0 to 7.0% by weight, 1.0 to 7.0% by weight of omija, 1.0 to 7.0% by weight of raw paper, 1.0 to 7.0% by weight of porridge, 1.0 to 5.0% by weight of licorice, and 1.0 to 5.0% by weight of cinnamon An extraction step (S10) of preparing a herbal medicine mixture and extracting a herbal medicine extract from the herbal medicine mixture;
Concentrating the herbal medicine extract extracted in the extraction step (S10) to prepare a herbal medicine concentrate (S20);
Sanjoin 1.0 to 10.0 wt%, Cheonma 1.0 to 8.0 wt%, Baekjamgam 1.0 to 7.0 wt%, Gamguk 1.0 to 15.0 wt%, Gugija 1.0 to 15.0 wt%, Gilgyeong 1.0 to 15.0 wt%, Angelica 1.0 to 15.0 wt%, Maekmundong 1.0 to 15.0% by weight, Baekbokshin 1.0 to 10.0% by weight, Baekchul 1.0 to 10.0% by weight, Mountain breeding 1.0 to 10.0% by weight, Sanyak 1.0 to 10.0% by weight, Longan meat 1.0 to 8.0% by weight, Wooseul 1.0 to 8.0% by weight, Peony 1.0 to 8.0% by weight, jujube 1.0 to 7.0% by weight, 1.0 to 7.0% by weight of omija, 1.0 to 7.0% by weight of raw paper, 1.0 to 7.0% by weight of porridge, 1.0 to 5.0% by weight of licorice, and 1.0 to 5.0% by weight of cinnamon A herbal medicine powder manufacturing step (S30) of preparing a herbal medicine mixture, drying and pulverizing, to prepare a herbal medicine powder; and,
A pharmaceutical preparation step (S42) of mixing the herbal medicine concentrate prepared in the concentration step (S20) and the herbal medicine powder prepared in the herbal medicine powder production step (S30) to prepare granules, powders, or pills (S42) characterized in that it comprises Method for preparing a composition for improving muscle tics and depression.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20130086459A (en) * | 2012-01-25 | 2013-08-02 | 경희대학교 산학협력단 | Pharmaceutical composition for rapid acting prevention and treatment of depression comprising extract of zizyphus spinosa semen as an active ingredient |
| KR20130110608A (en) * | 2012-03-29 | 2013-10-10 | 경희대학교 산학협력단 | Pharmaceutical composition for rapid acting prevention and treatment of depression comprising extract of gastrodia elata blume as an active ingredient |
| KR101826737B1 (en) | 2016-07-29 | 2018-02-08 | 현주명 | A composition containing herbs extract, and manufacturing method of the same |
| KR20200072148A (en) * | 2018-12-12 | 2020-06-22 | 세명대학교 산학협력단 | Compositions for Improving Andropause Using Hybrid Oriental Medicine Materials and Health food using this same |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20130086459A (en) * | 2012-01-25 | 2013-08-02 | 경희대학교 산학협력단 | Pharmaceutical composition for rapid acting prevention and treatment of depression comprising extract of zizyphus spinosa semen as an active ingredient |
| KR20130110608A (en) * | 2012-03-29 | 2013-10-10 | 경희대학교 산학협력단 | Pharmaceutical composition for rapid acting prevention and treatment of depression comprising extract of gastrodia elata blume as an active ingredient |
| KR101826737B1 (en) | 2016-07-29 | 2018-02-08 | 현주명 | A composition containing herbs extract, and manufacturing method of the same |
| KR20200072148A (en) * | 2018-12-12 | 2020-06-22 | 세명대학교 산학협력단 | Compositions for Improving Andropause Using Hybrid Oriental Medicine Materials and Health food using this same |
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