KR102316913B9 - 마이크로채널 네트워크가 형성된 하이드로젤 구조체를 포함하는 인공 조직 모델 - Google Patents

마이크로채널 네트워크가 형성된 하이드로젤 구조체를 포함하는 인공 조직 모델

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Publication number
KR102316913B9
KR102316913B9 KR1020200037404A KR20200037404A KR102316913B9 KR 102316913 B9 KR102316913 B9 KR 102316913B9 KR 1020200037404 A KR1020200037404 A KR 1020200037404A KR 20200037404 A KR20200037404 A KR 20200037404A KR 102316913 B9 KR102316913 B9 KR 102316913B9
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KR
South Korea
Prior art keywords
tissue model
artificial tissue
hydrogel structure
microchannel network
microchannel
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KR1020200037404A
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English (en)
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KR20200115343A (ko
KR102316913B1 (ko
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성학준
이정복
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연세대학교 산학협력단
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Publication of KR20200115343A publication Critical patent/KR20200115343A/ko
Application granted granted Critical
Publication of KR102316913B1 publication Critical patent/KR102316913B1/ko
Publication of KR102316913B9 publication Critical patent/KR102316913B9/ko

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0697—Artificial constructs associating cells of different lineages, e.g. tissue equivalents
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M21/00—Bioreactors or fermenters specially adapted for specific uses
    • C12M21/08—Bioreactors or fermenters specially adapted for specific uses for producing artificial tissue or for ex-vivo cultivation of tissue
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M3/00—Tissue, human, animal or plant cell, or virus culture apparatus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/067—Hepatocytes
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/12—Animals modified by administration of exogenous cells
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Environmental Sciences (AREA)
  • Cell Biology (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Animal Husbandry (AREA)
  • Sustainable Development (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
KR1020200037404A 2019-03-28 2020-03-27 마이크로채널 네트워크가 형성된 하이드로젤 구조체를 포함하는 인공 조직 모델 KR102316913B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020190036001 2019-03-28
KR20190036001 2019-03-28

Publications (3)

Publication Number Publication Date
KR20200115343A KR20200115343A (ko) 2020-10-07
KR102316913B1 KR102316913B1 (ko) 2021-10-25
KR102316913B9 true KR102316913B9 (ko) 2022-01-17

Family

ID=72609090

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020200037404A KR102316913B1 (ko) 2019-03-28 2020-03-27 마이크로채널 네트워크가 형성된 하이드로젤 구조체를 포함하는 인공 조직 모델

Country Status (2)

Country Link
KR (1) KR102316913B1 (ko)
WO (1) WO2020197326A1 (ko)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4349957A1 (en) * 2021-05-24 2024-04-10 Cellartgen Inc. Non-alcoholic fatty liver artificial tissue model
WO2022265352A1 (ko) * 2021-06-15 2022-12-22 연세대학교 산학협력단 다중 장기 모델
CN113717925B (zh) * 2021-08-19 2024-03-12 清华大学 一种人工肝脏类器官及其制备方法和应用
CN114159470A (zh) * 2021-12-10 2022-03-11 陈刚 一种Eze-ECM水凝胶的制备方法
KR20230146355A (ko) * 2022-04-12 2023-10-19 재단법인 아산사회복지재단 림프 부종을 예방 또는 치료하기 위한 인공구조물 및 이의 제조방법

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010096469A2 (en) * 2009-02-17 2010-08-26 William Marsh Rice University Fabrication of interconnected model vasculature
WO2016154070A1 (en) * 2015-03-20 2016-09-29 William Marsh Rice University Hypothermic 3d bioprinting of living tissues supported by perfusable vasculature

Also Published As

Publication number Publication date
KR20200115343A (ko) 2020-10-07
WO2020197326A1 (ko) 2020-10-01
KR102316913B1 (ko) 2021-10-25

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