KR102134466B1 - Cosmetic composition and preparation method of the same - Google Patents

Cosmetic composition and preparation method of the same Download PDF

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KR102134466B1
KR102134466B1 KR1020190001380A KR20190001380A KR102134466B1 KR 102134466 B1 KR102134466 B1 KR 102134466B1 KR 1020190001380 A KR1020190001380 A KR 1020190001380A KR 20190001380 A KR20190001380 A KR 20190001380A KR 102134466 B1 KR102134466 B1 KR 102134466B1
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remaining amount
weight
cosmetic composition
hydroxyacetophenone
composition
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KR20200085176A (en
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김성호
김태호
송유진
홍충민
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주식회사 에스앤지
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/35—Ketones, e.g. benzophenone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/345—Alcohols containing more than one hydroxy group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37—Esters of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
    • A61K8/4926—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having six membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/005—Antimicrobial preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/70—Biological properties of the composition as a whole
    • A61K2800/72—Hypo-allergenic

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Dermatology (AREA)
  • Cosmetics (AREA)

Abstract

본 발명은 화장료 조성물에 관한 것으로, 하이드록시아세토페논(4'-Hydroxyacetophenone) 및 라우릴피리디늄클로라이드(laurylpyridinium chloride)을 포함함으로써 피부에 저자극성이면서 광범위한 항균력을 가지는 화장료 조성물 및 이의 제조 방법에 관한 것이다.The present invention relates to a cosmetic composition, by including hydroxyacetophenone (4'-Hydroxyacetophenone) and laurylpyridinium chloride (laurylpyridinium chloride) relates to a cosmetic composition having a hypoallergenic and broad antibacterial activity to the skin and a method for manufacturing the same .

Description

화장료 조성물 및 이의 제조 방법{COSMETIC COMPOSITION AND PREPARATION METHOD OF THE SAME}Cosmetic composition and method for manufacturing the same{COSMETIC COMPOSITION AND PREPARATION METHOD OF THE SAME}

본 발명은 광범위한 항균 및 방부 활성을 갖는 화장료 조성물 및 이의 제조 방법에 관한 것이다.The present invention relates to a cosmetic composition having a wide range of antibacterial and antiseptic activity and a method for manufacturing the same.

일반적으로 부패나 변패의 원인이 되는 진균류에 속하는 세균, 곰팡이 및 효모 등의 미생물을 사멸시키거나 그 증식을 억제하는 작용으로 미생물 증식이나 원하지 않은 화학적 변화로 인한 부패를 방지하고 일정 기간 보존 하고자 식품, 화장품, 의약품 등과 같은 다양한 제품에 방부제가 사용되고 있다.In general, it kills microorganisms such as bacteria, fungi and yeast belonging to the fungi that cause decay or deterioration, or inhibits their growth.It is a food to prevent spoilage due to microbial growth or unwanted chemical changes and to preserve it for a certain period of time. Preservatives are used in various products such as cosmetics and medicines.

일반적으로 방부제로 사용되고 있는 물질로는 대부분 화학적으로 합성한 인공물질 들이 사용되고 있으며 예를 들어, 클로로메틸이소치아졸리논(Chloromethylisothiazolinone, CMIT), 3-요오드-2-프로파이닐부틸카바메이트(3-lodo-2-propynylbutylcarbamate, IPBC), 벤잘코니윰클로라이드(Benzalkonium Chloride, BKC), PHMG(polyhexamethylene guanidine), PHMB(polyhexamethylene biguanide), 파라벤(Paraben)류, 이미다졸리디닐 우레아, 디아졸리디닐 우레아, 알코올(Alchol) 등이 항균제 및 방부제로 사용하고 있다.In general, most chemically synthesized artificial substances are used as materials used as a preservative, for example, chloromethylisothiazolinone (CMIT), 3-iodo-2-propynylbutyl carbamate (3- lodo-2-propynylbutylcarbamate (IPBC), Benzalkonium Chloride (BKC), polyhexamethylene guanidine (PHMG), polyhexamethylene biguanide (PHMB), parabens, imidazolidinyl urea, diazolidinyl urea, alcohol (Alchol) and others are used as antibacterial and antiseptic agents.

그러나 상기 파라벤(Paraben)류 방부제는 피부 알러지와 내성균 유발 등의 문제점을 가지고 있다. 또한, PHMG, PHMB 및 PGH과 같은 구아디닌계 물질은 가습기용 살균제에 의한 급성폐손상 증후권의 원인물질으로 위험성이 이슈화되는 등 많은 문제점이 있다.However, the paraben (Paraben) preservatives have problems such as skin allergy and resistant bacteria. In addition, guadinine-based substances such as PHMG, PHMB and PGH have many problems, such as risks, as a causative agent of acute lung injury symptoms caused by disinfectants for humidifiers.

상기한 바와 같이, 이러한 인공방부제의 위험성이 대두되고 있어 최근 화장품 및 식품 업계는 인체 독성이 최소화된 물질로서 파라벤 뿐만 아니라 방부제로 사용하고 있는 각종 화학물질들을 천연 소재 물질 등으로 대체하는 연구가 대두되고 있다. 그러나 천연 소재의 비싼 가격과 천연 소재에 대한 가공 기술력의 미비 등으로 인하여 천연 소재를 방부제로 사용하지 못하고 있다. 또한, 천연활성 물질들의 경우, 대부분 색취, 안정성 저하, 항균성이 떨어지며, 제형상의 문제점, 재연성 등으로 인하여 상용화되지 못하고 있다.As described above, the risk of such artificial preservatives has emerged, and recently, the cosmetics and food industry is researched to replace various chemicals used as preservatives as well as parabens as substances with minimal human toxicity. have. However, due to the high price of natural materials and the lack of processing technology for natural materials, natural materials cannot be used as preservatives. In addition, in the case of natural active materials, most of them are not commercialized due to poor color, stability, and antimicrobial properties, problems with formulations, and reproducibility.

따라서 기존 사용되던 항균 및 방부 물질을 대체할 수 있는 미생물에 대한 작용이 강하고 지속적일 뿐만 아니라 인체에 무해하거나 독성이 아주 낮아 장기적으로 사용하였을 때에도 전혀 해가 없는 항균 및 방부의 물질의 개발이 요구되고 있다.Therefore, it is required to develop an antibacterial and antiseptic substance that is not only harmless and persistent to the human body that is capable of substituting the previously used antibacterial and antiseptic substances, and is harmless to the human body or has very low toxicity, and is harmless even when used for a long time. have.

Andrea Counti et al., Contact Dermatitis, 1997, 37; 35-36Andrea Counti et al., Contact Dermatitis, 1997, 37; 35-36

본 발명은 앞서 설명한 바와 같이 현재 사용되고 있는 방부제의 문제점을 해결하기 위한 것으로, 인체에 무해하면서도 피부에 자극성이 없고 세균과 진균에 대해 광범위한 항균성 및 방부력이 향상된 화장료 조성물 및 이의 제조 방법을 제시하는 것을 목적으로 한다.The present invention is to solve the problems of the preservatives currently being used as described above, it is harmless to the human body and has no irritation to the skin, and suggests a cosmetic composition having improved antibacterial and antiseptic power against bacteria and fungi and a method for manufacturing the same The purpose.

상기와 같은 목적을 달성하기 위해 본 발명의 화장료 조성물은 4'-하이드록시아세토페논(4'-hydroxyacetophenone) 0.001 내지 30 중량%, 라우릴피리디늄클로라이드(laurylpyridinium chloride) 0.001 내지 30 중량%, 및 전체 조성물 총 중량이 100 중량%가 되도록 하는 잔량의 물을 포함할 수 있다.To achieve the above object, the cosmetic composition of the present invention is 4'-hydroxyacetophenone (4'-hydroxyacetophenone) 0.001 to 30% by weight, laurylpyridinium chloride (laurylpyridinium chloride) 0.001 to 30% by weight, and the whole The composition may include a residual amount of water such that the total weight is 100% by weight.

또 다른 본 발명의 화장료 조성물은 4'-하이드록시아세토페논(4'-hydroxyacetophenone) 0.001 내지 30 중량%, 라우릴피리디늄클로라이드(laurylpyridinium chloride) 0.001 내지 30 중량%, 소듐데하이드로아세테이트(sodium dehydroacetate), 소듐벤조에이트(sodium benzoate), 카프릴하이드록사믹산(caprylhydroxamic acid) 및 알칸디올(alkanediol) 중에서 선택되는 어느 하나의 화합물 0.01 내지 0.04 중량%, 및 전체 조성물 총 중량이 100 중량%가 되도록 하는 잔량의 물을 포함할 수 있다.Another cosmetic composition of the present invention is 4'-hydroxyacetophenone (4'-hydroxyacetophenone) 0.001 to 30% by weight, laurylpyridinium chloride (laurylpyridinium chloride) 0.001 to 30% by weight, sodium dehydroacetate (sodium dehydroacetate) , 0.01 to 0.04% by weight of any one compound selected from sodium benzoate, caprylhydroxamic acid, and alkanediol, and a residual amount such that the total weight of the total composition is 100% by weight It may contain water.

상기 화장료 조성물은, 상기 4'-하이드록시아세토페논의 함량이 0.1 중량% 이하이면, 상기 라우릴피리디늄클로라이드(laurylpyridinium chloride)는 0.001중량% 초과 30 중량% 이하로 포함되는 것이 바람직하다.The cosmetic composition, if the content of the 4'-hydroxyacetophenone is 0.1% by weight or less, the laurylpyridinium chloride (laurylpyridinium chloride) is preferably contained in more than 0.001% by weight and 30% by weight or less.

상기 알칸디올로는 옥탄디올(octandiol), 헥산디올(hexandiol) 및 프로판디올(propandiol) 중에서 선택되는 어느 하나 이상을 사용할 수 있으며, 바람직하게는 헥산디올(hexandiol)을 사용할 수 있다.As the alkanediol, any one or more selected from octandiol, hexanediol and propandiol may be used, and hexanediol may be used.

상기 화장료 조성물에서 추가로 클로르페네신(chlorphenesin) 및 트로폴론(tropolone) 중에서 선택되는 어느 하나 이상의 화합물을 조성물 총 중량에 대하여 1 내지 40 중량% 더 포함할 수 있다.In the cosmetic composition, chlorphenesin (chlorphenesin) and one or more compounds selected from tropolone (tropolone) may further include 1 to 40% by weight based on the total weight of the composition.

상기 화장료 조성물은 대장균(Escherichia coli), 포도상 구균(Staphyloccoccus aureus), 녹농균(Pseudomonas aeruginosa), 칸디다 알비칸스(Candida albicans) 및 아스퍼질러스 니거(Aspergillus niger) 모두에 대해 항균성을 가진다.The cosmetic composition is Escherichia coli coli ), Staphylococcus aureus ( Staphyloccoccus aureus), Pseudomonas aeruginosa (Pseudomonas aeruginosa), Candida albicans (Candida albicans ) and Aspergillus niger .

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상기 화장료 조성물의 제형은 수용액, 에멀전, 디스퍼젼(dispersion), 서스펜션(suspension) 및 유용액 중에서 선택되는 어느 하나 이상일 수 있으며, 이에 반드시 한정된 것은 아니고 다양한 화장품 제형상으로 사용될 수 있다.The formulation of the cosmetic composition may be any one or more selected from aqueous solutions, emulsions, dispersions, suspensions, and useful solutions, and is not necessarily limited thereto, and may be used in various cosmetic formulations.

또한, 상기와 같은 목적을 달성하기 위해 본 발명의 화장료 조성물의 제조방법은 물에 4'-하이드록시아세토페논(4'-hydroxyacetophenone) 및 라우릴피리디늄클로라이드(laurylpyridinium chloride)을 넣고 교반하여 화장료 조성물을 제조하는 단계를 포함할 수 있다.In addition, in order to achieve the above object, the method for preparing the cosmetic composition of the present invention is 4'-hydroxyacetophenone (4'-hydroxyacetophenone) and laurylpyridinium chloride (laurylpyridinium chloride) and stirred by adding a cosmetic composition It may include the step of manufacturing.

또 다른 본 발명의 화장료 조성믈의 제조 방법으로 물에 4'-하이드록시아세토페논(4'-hydroxyacetophenone), 라우릴피리디늄클로라이드(laurylpyridinium chloride) 및 소듐데하이드로아세테이트(sodium dehydroacetate), 소듐벤조에이트(sodium benzoate), 카프릴하이드록사믹산(caprylhydroxamic acid) 및 알칸디올(alkanediol) 중에서 선택되는 어느 하나의 화합물을 넣고 교반하여 화장료 조성물을 제조하는 단계를 포함할 수 있다.In another method of preparing a cosmetic composition of the present invention, 4'-hydroxyacetophenone, 4,-hydroxyacetophenone, laurylpyridinium chloride, sodium dehydroacetate, and sodium benzoate (sodium benzoate), capryl hydroxamic acid (caprylhydroxamic acid) and alkanediol (alkanediol) may include a step of preparing a cosmetic composition by adding and stirring any one compound selected from.

상기 화장료 조성물을 제조하는 단계는, 4'-하이드록시아세토페논(4'-hydroxyacetophenone) 0.001 내지 30 중량%, 라우릴피리디늄클로라이드(laurylpyridinium chloride) 0.001 내지 30 중량%, 소듐데하이드로아세테이트(sodium dehydroacetate), 소듐벤조에이트(sodium benzoate), 카프릴하이드록사믹산(caprylhydroxamic acid) 및 알칸디올(alkanediol) 중에서 선택되는 어느 하나의 화합물 0.01 내지 0.04 중량%, 및 전체 조성물 총 중량이 100 중량%가 되도록 하는 잔량의 물을 넣고 교반하여 화장료 조성물을 제조할 수 있다.The step of preparing the cosmetic composition, 4'-hydroxyacetophenone (4'-hydroxyacetophenone) 0.001 to 30% by weight, laurylpyridinium chloride (laurylpyridinium chloride) 0.001 to 30% by weight, sodium dehydroacetate (sodium dehydroacetate) ), sodium benzoate (sodium benzoate), capryl hydroxamic acid (caprylhydroxamic acid) and any one compound selected from alkanediol (alkanediol) 0.01 to 0.04% by weight, and the total weight of the total composition to 100% The remaining amount of water is added and stirred to prepare a cosmetic composition.

또한 상기 화장료 조성물은 상상기 4'-하이드록시아세토페논의 함량이 0.1 중량% 이하이면, 상기 라우릴피리디늄클로라이드(laurylpyridinium chloride)는 0.001중량% 초과 30 중량% 이하로 포함되는 것이 바람직하다.In addition, if the content of the cosmetic composition is 4'-hydroxyacetophenone of 0.1% by weight or less, the laurylpyridinium chloride (laurylpyridinium chloride) is preferably included more than 0.001% by weight and 30% by weight or less.

상기 화장료 조성물을 제조하는 단계는, 화장료 조성물에 클로르페네신(chlorphenesin) 및 트로폴론(tropolone) 중에서 선택되는 어느 하나 이상의 화합물을 조성물 총 중량에 대하여 1 내지 40 중량%를 더 첨가할 수 있다.In the step of preparing the cosmetic composition, any one or more compounds selected from chlorphenesin and tropolone may be added to the cosmetic composition in an amount of 1 to 40% by weight based on the total weight of the composition.

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본 발명의 화장품 조성물에서 소듐데하이드로아세테이트(sodium dehydroacetate), 소듐벤조에이트(sodium benzoate), 카프릴하이드록사믹산(caprylhydroxamic acid), 알칸디올(alkanediol)의 유기산을 제시하였으나 이에 반드시 한정된 것은 아니며, 이 기술 분야의 통상의 기술자에게 알려진 항균효과를 나타내는 유기산 등을 사용할 수 있다.In the cosmetic composition of the present invention, sodium dehydroacetate, sodium benzoate, caprylhydroxamic acid, and alkanediol organic acid are presented, but are not limited thereto. Organic acids, etc., which exhibit antibacterial effects known to those skilled in the art can be used.

본 발명의 화장품 조성물은 진균류와 세균류를 포함하는 광범위한 항균 또는 방부 활성을 가지면서도 피부 자극성이 낮고 인체에 무해하여 안정성이 높아 항균 및 방부제로서 다양한 화장품 제품에 유용하게 사용될 수 있다.The cosmetic composition of the present invention has a wide range of antibacterial or antiseptic activity, including fungi and bacteria, but has low skin irritation and harmlessness to the human body, and thus has high stability, and thus can be usefully used in various cosmetic products as an antibacterial and antiseptic.

이하, 실시예를 통해 본 발명을 보다 자세히 설명하지만, 이들 실시예는 본 발명을 위한 화장료 조성물의 한 예시일 뿐이며 본 발명의 범위가 이들 실시예에 한정되는 것은 아니고, 본 발명의 기술적 사상을 벗어나지 않는 범위 내에서 여러 가지 수정, 변형 및 변경이 가능하다는 것이 당업자에게 있어 명백할 것이며, 당업자에 의해 용이하게 변경 가능한 부분도 본 발명의 권리범위에 포함됨은 자명하다.Hereinafter, the present invention will be described in more detail through Examples, but these Examples are only examples of cosmetic compositions for the present invention, and the scope of the present invention is not limited to these Examples, and does not depart from the technical spirit of the present invention. It will be apparent to those skilled in the art that various modifications, variations, and changes can be made within the scope of the present invention, and it is obvious that portions easily changeable by those skilled in the art are included in the scope of the present invention.

다음 표 1 내지 표 4에 기재된 바와 같은 4'-하이드록시아세토페논(4'-hydroxyacetophenone), 라우릴피리디늄클로라이드(laurylpyridinium chloride) 및 소듐데하이드로아세테이트(sodium dehydroacetate), 소듐벤조에이트(sodium benzoate), 카프릴하이드록사믹산(caprylhydroxamic acid) 및 1,2-헥산디올(hexandiol) 중에서 선택되는 어느 하나의 화합물의 성분 및 함량을 정제수에 넣고 완전히 용해되도록 교반기로 교반하여 실시예의 화장료 조성물을 제조하였다.4'-hydroxyacetophenone, laurylpyridinium chloride and sodium dehydroacetate, sodium benzoate as described in Tables 1 to 4 below. , Caprylhydroxamic acid (caprylhydroxamic acid) and 1,2-hexanediol (hexandiol) of the compound and the content of any one selected from purified water was added to purified water and stirred with a stirrer to completely dissolve to prepare the cosmetic composition of the Examples.

하기 표 1 내지 표 4에서 "4'-HDP"는 4'-하이드록시아세토페논(4'-hydroxyacetophenone)이고, "LPC"는 라우릴피리디늄클로라이드(laurylpyridinium chloride)이고, "SDA"는 소듐데하이드로아세테이트(sodium dehydroacetate)이고, "CHA"는 카프릴하이드록사믹산(caprylhydroxamic acid)이고, "SBA"는 소듐벤조에이트(sodium benzoate)이며, "HXD"는 1,2-헥산디올(1,2-hexandiol)을 의미한다.In Tables 1 to 4, "4'-HDP" is 4'-hydroxyacetophenone, "LPC" is laurylpyridinium chloride, and "SDA" is sodium. Sodium dehydroacetate, "CHA" is caprylhydroxamic acid, "SBA" is sodium benzoate, "HXD" is 1,2-hexanediol (1,2) -hexandiol).

표 1에 나타낸 실시예 1-1 내지 실시예 1-75은 4'-하이드록시아세토페논(4'-hydroxyacetophenone), 라우릴피리디늄클로라이드(laurylpyridinium chloride) 및 유기산으로 소듐데하이드로아세테이트(sodium dehydroacetate)의 성분 및 함량을 하기 표 1에서와 같이 제조된 화장료 조성물이다.Examples 1-1 to 1-75 shown in Table 1 are 4'-hydroxyacetophenone, laurylpyridinium chloride, and sodium dehydroacetate as organic acids. The ingredients and contents of the cosmetic composition prepared as in Table 1 below.

구분division 4'-HDP4'-HDP LPCLPC SDASDA 정제수Purified water 중량%weight% 실시예1-1Example 1-1 3030 3030 0.040.04 잔량(to 100)Remaining amount (to 100) 실시예1-2Example 1-2 3030 3030 0.020.02 잔량(to 100)Remaining amount (to 100) 실시예1-3Example 1-3 3030 3030 0.010.01 잔량(to 100)Remaining amount (to 100) 실시예1-4Example 1-4 3030 0.50.5 0.040.04 잔량(to 100)Remaining amount (to 100) 실시예1-5Example 1-5 3030 0.50.5 0.020.02 잔량(to 100)Remaining amount (to 100) 실시예1-6Example 1-6 3030 0.50.5 0.010.01 잔량(to 100)Remaining amount (to 100) 실시예1-7Example 1-7 3030 0.10.1 0.040.04 잔량(to 100)Remaining amount (to 100) 실시예1-8Example 1-8 3030 0.10.1 0.020.02 잔량(to 100)Remaining amount (to 100) 실시예1-9Example 1-9 3030 0.10.1 0.010.01 잔량(to 100)Remaining amount (to 100) 실시예1-10Example 1-10 3030 0.040.04 0.040.04 잔량(to 100)Remaining amount (to 100) 실시예1-11Example 1-11 3030 0.040.04 0.020.02 잔량(to 100)Remaining amount (to 100) 실시예1-12Example 1-12 3030 0.040.04 0.010.01 잔량(to 100)Remaining amount (to 100) 실시예1-13Example 1-13 3030 0.0010.001 0.040.04 잔량(to 100)Remaining amount (to 100) 실시예1-14Example 1-14 3030 0.0010.001 0.020.02 잔량(to 100)Remaining amount (to 100) 실시예1-15Example 1-15 3030 0.0010.001 0.010.01 잔량(to 100)Remaining amount (to 100) 실시예1-16Example 1-16 0.50.5 3030 0.040.04 잔량(to 100)Remaining amount (to 100) 실시예1-17Example 1-17 0.50.5 3030 0.020.02 잔량(to 100)Remaining amount (to 100) 실시예1-18Example 1-18 0.50.5 3030 0.010.01 잔량(to 100)Remaining amount (to 100) 실시예1-19Example 1-19 0.50.5 0.50.5 0.040.04 잔량(to 100)Remaining amount (to 100) 실시예1-20Example 1-20 0.50.5 0.50.5 0.020.02 잔량(to 100)Remaining amount (to 100) 실시예1-21Example 1-21 0.50.5 0.50.5 0.010.01 잔량(to 100)Remaining amount (to 100) 실시예1-22Example 1-22 0.50.5 0.10.1 0.040.04 잔량(to 100)Remaining amount (to 100) 실시예1-23Example 1-23 0.50.5 0.10.1 0.020.02 잔량(to 100)Remaining amount (to 100) 실시예1-24Example 1-24 0.50.5 0.10.1 0.010.01 잔량(to 100)Remaining amount (to 100) 실시예1-25Example 1-25 0.50.5 0.040.04 0.040.04 잔량(to 100)Remaining amount (to 100) 실시예1-26Example 1-26 0.50.5 0.040.04 0.020.02 잔량(to 100)Remaining amount (to 100) 실시예1-27Example 1-27 0.50.5 0.040.04 0.010.01 잔량(to 100)Remaining amount (to 100) 실시예1-28Example 1-28 0.50.5 0.0010.001 0.040.04 잔량(to 100)Remaining amount (to 100) 실시예1-29Example 1-29 0.50.5 0.0010.001 0.020.02 잔량(to 100)Remaining amount (to 100) 실시예1-30Example 1-30 0.50.5 0.0010.001 0.010.01 잔량(to 100)Remaining amount (to 100) 실시예1-31Example 1-31 0.10.1 3030 0.040.04 잔량(to 100)Remaining amount (to 100) 실시예1-32Example 1-32 0.10.1 3030 0.020.02 잔량(to 100)Remaining amount (to 100) 실시예1-33Example 1-33 0.10.1 3030 0.010.01 잔량(to 100)Remaining amount (to 100) 실시예1-34Example 1-34 0.10.1 0.50.5 0.040.04 잔량(to 100)Remaining amount (to 100) 실시예1-35Example 1-35 0.10.1 0.50.5 0.020.02 잔량(to 100)Remaining amount (to 100) 실시예1-36Example 1-36 0.10.1 0.50.5 0.010.01 잔량(to 100)Remaining amount (to 100) 실시예1-37Example 1-37 0.10.1 0.10.1 0.040.04 잔량(to 100)Remaining amount (to 100) 실시예1-38Example 1-38 0.10.1 0.10.1 0.020.02 잔량(to 100)Remaining amount (to 100) 실시예1-39Example 1-39 0.10.1 0.10.1 0.010.01 잔량(to 100)Remaining amount (to 100) 실시예1-40Example 1-40 0.10.1 0.040.04 0.040.04 잔량(to 100)Remaining amount (to 100) 실시예1-41Example 1-41 0.10.1 0.040.04 0.020.02 잔량(to 100)Remaining amount (to 100) 실시예1-42Example 1-42 0.10.1 0.040.04 0.010.01 잔량(to 100)Remaining amount (to 100) 실시예1-43Example 1-43 0.10.1 0.0010.001 0.040.04 잔량(to 100)Remaining amount (to 100) 실시예1-44Example 1-44 0.10.1 0.0010.001 0.020.02 잔량(to 100)Remaining amount (to 100) 실시예1-45Example 1-45 0.10.1 0.0010.001 0.010.01 잔량(to 100)Remaining amount (to 100) 실시예1-46Example 1-46 0.040.04 3030 0.040.04 잔량(to 100)Remaining amount (to 100) 실시예1-47Example 1-47 0.040.04 3030 0.020.02 잔량(to 100)Remaining amount (to 100) 실시예1-48Example 1-48 0.040.04 3030 0.010.01 잔량(to 100)Remaining amount (to 100) 실시예1-49Example 1-49 0.040.04 0.50.5 0.040.04 잔량(to 100)Remaining amount (to 100) 실시예1-50Example 1-50 0.040.04 0.50.5 0.020.02 잔량(to 100)Remaining amount (to 100) 실시예1-51Example 1-51 0.040.04 0.50.5 0.010.01 잔량(to 100)Remaining amount (to 100) 실시예1-52Example 1-52 0.040.04 0.10.1 0.040.04 잔량(to 100)Remaining amount (to 100) 실시예1-53Example 1-53 0.040.04 0.10.1 0.020.02 잔량(to 100)Remaining amount (to 100) 실시예1-54Example 1-54 0.040.04 0.10.1 0.010.01 잔량(to 100)Remaining amount (to 100) 실시예1-55Example 1-55 0.040.04 0.040.04 0.040.04 잔량(to 100)Remaining amount (to 100) 실시예1-56Example 1-56 0.040.04 0.040.04 0.020.02 잔량(to 100)Remaining amount (to 100) 실시예1-57Example 1-57 0.040.04 0.040.04 0.010.01 잔량(to 100)Remaining amount (to 100) 실시예1-58Example 1-58 0.040.04 0.0010.001 0.040.04 잔량(to 100)Remaining amount (to 100) 실시예1-59Example 1-59 0.040.04 0.0010.001 0.020.02 잔량(to 100)Remaining amount (to 100) 실시예1-60Example 1-60 0.040.04 0.0010.001 0.010.01 잔량(to 100)Remaining amount (to 100) 실시예1-61Example 1-61 0.0010.001 3030 0.040.04 잔량(to 100)Remaining amount (to 100) 실시예1-62Example 1-62 0.0010.001 3030 0.020.02 잔량(to 100)Remaining amount (to 100) 실시예1-63Example 1-63 0.0010.001 3030 0.010.01 잔량(to 100)Remaining amount (to 100) 실시예1-64Example 1-64 0.0010.001 0.50.5 0.040.04 잔량(to 100)Remaining amount (to 100) 실시예1-65Example 1-65 0.0010.001 0.50.5 0.020.02 잔량(to 100)Remaining amount (to 100) 실시예1-66Example 1-66 0.0010.001 0.50.5 0.010.01 잔량(to 100)Remaining amount (to 100) 실시예1-67Example 1-67 0.0010.001 0.10.1 0.040.04 잔량(to 100)Remaining amount (to 100) 실시예1-68Example 1-68 0.0010.001 0.10.1 0.020.02 잔량(to 100)Remaining amount (to 100) 실시예1-69Example 1-69 0.0010.001 0.10.1 0.010.01 잔량(to 100)Remaining amount (to 100) 실시예1-70Example 1-70 0.0010.001 0.040.04 0.040.04 잔량(to 100)Remaining amount (to 100) 실시예1-71Example 1-71 0.0010.001 0.040.04 0.020.02 잔량(to 100)Remaining amount (to 100) 실시예1-72Example 1-72 0.0010.001 0.040.04 0.010.01 잔량(to 100)Remaining amount (to 100) 실시예1-73Example 1-73 0.0010.001 0.0010.001 0.040.04 잔량(to 100)Remaining amount (to 100) 실시예1-74Example 1-74 0.0010.001 0.0010.001 0.020.02 잔량(to 100)Remaining amount (to 100) 실시예1-75Example 1-75 0.0010.001 0.0010.001 0.010.01 잔량(to 100)Remaining amount (to 100)

표 2에 나타낸 실시예 2-1 내지 실시예 2-75는 4'-하이드록시아세토페논(4'-hydroxyacetophenone), 라우릴피리디늄클로라이드(laurylpyridinium chloride) 및 카프릴하이드록사믹산(caprylhydroxamic acid)의 성분 및 함량을 하기 표 2에서와 같이 넣어 제조된 화장료 조성물이다.Examples 2-1 to 2 2-75 shown in Table 2 are 4'-hydroxyacetophenone, laurylpyridinium chloride and caprylhydroxamic acid. It is a cosmetic composition prepared by putting the ingredients and contents as shown in Table 2 below.

구분division 4'-HDP4'-HDP LPCLPC CHACHA 정제수Purified water 중량%weight% 실시예2-1Example 2-1 3030 3030 0.040.04 잔량(to 100)Remaining amount (to 100) 실시예2-2Example 2-2 3030 3030 0.020.02 잔량(to 100)Remaining amount (to 100) 실시예2-3Example 2-3 3030 3030 0.010.01 잔량(to 100)Remaining amount (to 100) 실시예2-4Example 2-4 3030 0.50.5 0.040.04 잔량(to 100)Remaining amount (to 100) 실시예2-5Example 2-5 3030 0.50.5 0.020.02 잔량(to 100)Remaining amount (to 100) 실시예2-6Example 2-6 3030 0.50.5 0.010.01 잔량(to 100)Remaining amount (to 100) 실시예2-7Example 2-7 3030 0.10.1 0.040.04 잔량(to 100)Remaining amount (to 100) 실시예2-8Example 2-8 3030 0.10.1 0.020.02 잔량(to 100)Remaining amount (to 100) 실시예2-9Example 2-9 3030 0.10.1 0.010.01 잔량(to 100)Remaining amount (to 100) 실시예2-10Example 2-10 3030 0.040.04 0.040.04 잔량(to 100)Remaining amount (to 100) 실시예2-11Example 2-11 3030 0.040.04 0.020.02 잔량(to 100)Remaining amount (to 100) 실시예2-12Example 2-12 3030 0.040.04 0.010.01 잔량(to 100)Remaining amount (to 100) 실시예2-13Example 2-13 3030 0.0010.001 0.040.04 잔량(to 100)Remaining amount (to 100) 실시예2-14Example 2-14 3030 0.0010.001 0.020.02 잔량(to 100)Remaining amount (to 100) 실시예2-15Example 2-15 3030 0.0010.001 0.010.01 잔량(to 100)Remaining amount (to 100) 실시예2-16Example 2-16 0.50.5 3030 0.040.04 잔량(to 100)Remaining amount (to 100) 실시예2-17Example 2-17 0.50.5 3030 0.020.02 잔량(to 100)Remaining amount (to 100) 실시예2-18Example 2-18 0.50.5 3030 0.010.01 잔량(to 100)Remaining amount (to 100) 실시예2-19Example 2-19 0.50.5 0.50.5 0.040.04 잔량(to 100)Remaining amount (to 100) 실시예2-20Example 2-20 0.50.5 0.50.5 0.020.02 잔량(to 100)Remaining amount (to 100) 실시예2-21Example 2-21 0.50.5 0.50.5 0.010.01 잔량(to 100)Remaining amount (to 100) 실시예2-22Example 2-22 0.50.5 0.10.1 0.040.04 잔량(to 100)Remaining amount (to 100) 실시예2-23Example 2-23 0.50.5 0.10.1 0.020.02 잔량(to 100)Remaining amount (to 100) 실시예2-24Example 2-24 0.50.5 0.10.1 0.010.01 잔량(to 100)Remaining amount (to 100) 실시예2-25Example 2-25 0.50.5 0.040.04 0.040.04 잔량(to 100)Remaining amount (to 100) 실시예2-26Example 2-26 0.50.5 0.040.04 0.020.02 잔량(to 100)Remaining amount (to 100) 실시예2-27Example 2-27 0.50.5 0.040.04 0.010.01 잔량(to 100)Remaining amount (to 100) 실시예2-28Example 2-28 0.50.5 0.0010.001 0.040.04 잔량(to 100)Remaining amount (to 100) 실시예2-29Example 2-29 0.50.5 0.0010.001 0.020.02 잔량(to 100)Remaining amount (to 100) 실시예2-30Example 2-30 0.50.5 0.0010.001 0.010.01 잔량(to 100)Remaining amount (to 100) 실시예2-31Example 2-31 0.10.1 3030 0.040.04 잔량(to 100)Remaining amount (to 100) 실시예2-32Example 2-32 0.10.1 3030 0.020.02 잔량(to 100)Remaining amount (to 100) 실시예2-33Example 2-33 0.10.1 3030 0.010.01 잔량(to 100)Remaining amount (to 100) 실시예2-34Example 2-34 0.10.1 0.50.5 0.040.04 잔량(to 100)Remaining amount (to 100) 실시예2-35Example 2-35 0.10.1 0.50.5 0.020.02 잔량(to 100)Remaining amount (to 100) 실시예2-36Example 2-36 0.10.1 0.50.5 0.010.01 잔량(to 100)Remaining amount (to 100) 실시예2-37Example 2-37 0.10.1 0.10.1 0.040.04 잔량(to 100)Remaining amount (to 100) 실시예2-38Example 2-38 0.10.1 0.10.1 0.020.02 잔량(to 100)Remaining amount (to 100) 실시예2-39Example 2-39 0.10.1 0.10.1 0.010.01 잔량(to 100)Remaining amount (to 100) 실시예2-40Example 2-40 0.10.1 0.040.04 0.040.04 잔량(to 100)Remaining amount (to 100) 실시예2-41Example 2-41 0.10.1 0.040.04 0.020.02 잔량(to 100)Remaining amount (to 100) 실시예2-42Example 2-42 0.10.1 0.040.04 0.010.01 잔량(to 100)Remaining amount (to 100) 실시예2-43Example 2-43 0.10.1 0.0010.001 0.040.04 잔량(to 100)Remaining amount (to 100) 실시예2-44Example 2-44 0.10.1 0.0010.001 0.020.02 잔량(to 100)Remaining amount (to 100) 실시예2-45Example 2-45 0.10.1 0.0010.001 0.010.01 잔량(to 100)Remaining amount (to 100) 실시예2-46Example 2-46 0.040.04 3030 0.040.04 잔량(to 100)Remaining amount (to 100) 실시예2-47Example 2-47 0.040.04 3030 0.020.02 잔량(to 100)Remaining amount (to 100) 실시예2-48Example 2-48 0.040.04 3030 0.010.01 잔량(to 100)Remaining amount (to 100) 실시예2-49Example 2-49 0.040.04 0.50.5 0.040.04 잔량(to 100)Remaining amount (to 100) 실시예2-50Example 2-50 0.040.04 0.50.5 0.020.02 잔량(to 100)Remaining amount (to 100) 실시예2-51Example 2-51 0.040.04 0.50.5 0.010.01 잔량(to 100)Remaining amount (to 100) 실시예2-52Example 2-52 0.040.04 0.10.1 0.040.04 잔량(to 100)Remaining amount (to 100) 실시예2-53Example 2-53 0.040.04 0.10.1 0.020.02 잔량(to 100)Remaining amount (to 100) 실시예2-54Example 2-54 0.040.04 0.10.1 0.010.01 잔량(to 100)Remaining amount (to 100) 실시예2-55Example 2-55 0.040.04 0.040.04 0.040.04 잔량(to 100)Remaining amount (to 100) 실시예2-56Example 2-56 0.040.04 0.040.04 0.020.02 잔량(to 100)Remaining amount (to 100) 실시예2-57Example 2-57 0.040.04 0.040.04 0.010.01 잔량(to 100)Remaining amount (to 100) 실시예2-58Example 2-58 0.040.04 0.0010.001 0.040.04 잔량(to 100)Remaining amount (to 100) 실시예2-59Example 2-59 0.040.04 0.0010.001 0.020.02 잔량(to 100)Remaining amount (to 100) 실시예2-60Example 2-60 0.040.04 0.0010.001 0.010.01 잔량(to 100)Remaining amount (to 100) 실시예2-61Example 2-61 0.0010.001 3030 0.040.04 잔량(to 100)Remaining amount (to 100) 실시예2-62Example 2-62 0.0010.001 3030 0.020.02 잔량(to 100)Remaining amount (to 100) 실시예2-63Example 2-63 0.0010.001 3030 0.010.01 잔량(to 100)Remaining amount (to 100) 실시예2-64Example 2-64 0.0010.001 0.50.5 0.040.04 잔량(to 100)Remaining amount (to 100) 실시예2-65Example 2-65 0.0010.001 0.50.5 0.020.02 잔량(to 100)Remaining amount (to 100) 실시예2-66Example 2-66 0.0010.001 0.50.5 0.010.01 잔량(to 100)Remaining amount (to 100) 실시예2-67Example 2-67 0.0010.001 0.10.1 0.040.04 잔량(to 100)Remaining amount (to 100) 실시예2-68Example 2-68 0.0010.001 0.10.1 0.020.02 잔량(to 100)Remaining amount (to 100) 실시예2-69Example 2-69 0.0010.001 0.10.1 0.010.01 잔량(to 100)Remaining amount (to 100) 실시예2-70Example 2-70 0.0010.001 0.040.04 0.040.04 잔량(to 100)Remaining amount (to 100) 실시예2-71Example 2-71 0.0010.001 0.040.04 0.020.02 잔량(to 100)Remaining amount (to 100) 실시예2-72Example 2-72 0.0010.001 0.040.04 0.010.01 잔량(to 100)Remaining amount (to 100) 실시예2-73Example 2-73 0.0010.001 0.0010.001 0.040.04 잔량(to 100)Remaining amount (to 100) 실시예2-74Example 2-74 0.0010.001 0.0010.001 0.020.02 잔량(to 100)Remaining amount (to 100) 실시예2-75Example 2-75 0.0010.001 0.0010.001 0.010.01 잔량(to 100)Remaining amount (to 100)

표 3에 나타낸 실시예 3-1 내지 실시예 3-75는 4'-하이드록시아세토페논(4'-hydroxyacetophenone), 라우릴피리디늄클로라이드(laurylpyridinium chloride) 및 유기산으로 소듐벤조에이트(sodium benzoate)의 성분 및 함량을 하기 표 3에서와 같이 넣어 제조된 화장료 조성물이다.Examples 3-1 to Examples 3-75 shown in Table 3 are 4'-hydroxyacetophenone, laurylpyridinium chloride, and organic acid as sodium benzoate. It is a cosmetic composition prepared by putting the ingredients and contents as shown in Table 3 below.

구분division 4'-HDP4'-HDP LPCLPC SBASBA 정제수Purified water 중량%weight% 실시예3-1Example 3-1 3030 3030 0.040.04 잔량(to 100)Remaining amount (to 100) 실시예3-2Example 3-2 3030 3030 0.020.02 잔량(to 100)Remaining amount (to 100) 실시예3-3Example 3-3 3030 3030 0.010.01 잔량(to 100)Remaining amount (to 100) 실시예3-4Example 3-4 3030 0.50.5 0.040.04 잔량(to 100)Remaining amount (to 100) 실시예3-5Example 3-5 3030 0.50.5 0.020.02 잔량(to 100)Remaining amount (to 100) 실시예3-6Example 3-6 3030 0.50.5 0.010.01 잔량(to 100)Remaining amount (to 100) 실시예3-7Example 3-7 3030 0.10.1 0.040.04 잔량(to 100)Remaining amount (to 100) 실시예3-8Example 3-8 3030 0.10.1 0.020.02 잔량(to 100)Remaining amount (to 100) 실시예3-9Example 3-9 3030 0.10.1 0.010.01 잔량(to 100)Remaining amount (to 100) 실시예3-10Example 3-10 3030 0.040.04 0.040.04 잔량(to 100)Remaining amount (to 100) 실시예3-11Example 3-11 3030 0.040.04 0.020.02 잔량(to 100)Remaining amount (to 100) 실시예3-12Example 3-12 3030 0.040.04 0.010.01 잔량(to 100)Remaining amount (to 100) 실시예3-13Example 3-13 3030 0.0010.001 0.040.04 잔량(to 100)Remaining amount (to 100) 실시예3-14Example 3-14 3030 0.0010.001 0.020.02 잔량(to 100)Remaining amount (to 100) 실시예3-15Example 3-15 3030 0.0010.001 0.010.01 잔량(to 100)Remaining amount (to 100) 실시예3-16Example 3-16 0.50.5 3030 0.040.04 잔량(to 100)Remaining amount (to 100) 실시예3-17Example 3-17 0.50.5 3030 0.020.02 잔량(to 100)Remaining amount (to 100) 실시예3-18Example 3-18 0.50.5 3030 0.010.01 잔량(to 100)Remaining amount (to 100) 실시예3-19Example 3-19 0.50.5 0.50.5 0.040.04 잔량(to 100)Remaining amount (to 100) 실시예3-20Example 3-20 0.50.5 0.50.5 0.020.02 잔량(to 100)Remaining amount (to 100) 실시예3-21Example 3-21 0.50.5 0.50.5 0.010.01 잔량(to 100)Remaining amount (to 100) 실시예3-22Example 3-22 0.50.5 0.10.1 0.040.04 잔량(to 100)Remaining amount (to 100) 실시예3-23Example 3-23 0.50.5 0.10.1 0.020.02 잔량(to 100)Remaining amount (to 100) 실시예3-24Example 3-24 0.50.5 0.10.1 0.010.01 잔량(to 100)Remaining amount (to 100) 실시예3-25Example 3-25 0.50.5 0.040.04 0.040.04 잔량(to 100)Remaining amount (to 100) 실시예3-26Example 3-26 0.50.5 0.040.04 0.020.02 잔량(to 100)Remaining amount (to 100) 실시예3-27Example 3-27 0.50.5 0.040.04 0.010.01 잔량(to 100)Remaining amount (to 100) 실시예3-28Example 3-28 0.50.5 0.0010.001 0.040.04 잔량(to 100)Remaining amount (to 100) 실시예3-29Example 3-29 0.50.5 0.0010.001 0.020.02 잔량(to 100)Remaining amount (to 100) 실시예3-30Example 3-30 0.50.5 0.0010.001 0.010.01 잔량(to 100)Remaining amount (to 100) 실시예3-31Example 3-31 0.10.1 3030 0.040.04 잔량(to 100)Remaining amount (to 100) 실시예3-32Example 3-32 0.10.1 3030 0.020.02 잔량(to 100)Remaining amount (to 100) 실시예3-33Example 3-33 0.10.1 3030 0.010.01 잔량(to 100)Remaining amount (to 100) 실시예3-34Example 3-34 0.10.1 0.50.5 0.040.04 잔량(to 100)Remaining amount (to 100) 실시예3-35Example 3-35 0.10.1 0.50.5 0.020.02 잔량(to 100)Remaining amount (to 100) 실시예3-36Example 3-36 0.10.1 0.50.5 0.010.01 잔량(to 100)Remaining amount (to 100) 실시예3-37Example 3-37 0.10.1 0.10.1 0.040.04 잔량(to 100)Remaining amount (to 100) 실시예3-38Example 3-38 0.10.1 0.10.1 0.020.02 잔량(to 100)Remaining amount (to 100) 실시예3-39Example 3-39 0.10.1 0.10.1 0.010.01 잔량(to 100)Remaining amount (to 100) 실시예3-40Example 3-40 0.10.1 0.040.04 0.040.04 잔량(to 100)Remaining amount (to 100) 실시예3-41Example 3-41 0.10.1 0.040.04 0.020.02 잔량(to 100)Remaining amount (to 100) 실시예3-42Example 3-42 0.10.1 0.040.04 0.010.01 잔량(to 100)Remaining amount (to 100) 실시예3-43Example 3-43 0.10.1 0.0010.001 0.040.04 잔량(to 100)Remaining amount (to 100) 실시예3-44Example 3-44 0.10.1 0.0010.001 0.020.02 잔량(to 100)Remaining amount (to 100) 실시예3-45Example 3-45 0.10.1 0.0010.001 0.010.01 잔량(to 100)Remaining amount (to 100) 실시예3-46Example 3-46 0.040.04 3030 0.040.04 잔량(to 100)Remaining amount (to 100) 실시예3-47Example 3-47 0.040.04 3030 0.020.02 잔량(to 100)Remaining amount (to 100) 실시예3-48Example 3-48 0.040.04 3030 0.010.01 잔량(to 100)Remaining amount (to 100) 실시예3-49Example 3-49 0.040.04 0.50.5 0.040.04 잔량(to 100)Remaining amount (to 100) 실시예3-50Example 3-50 0.040.04 0.50.5 0.020.02 잔량(to 100)Remaining amount (to 100) 실시예3-51Example 3-51 0.040.04 0.50.5 0.010.01 잔량(to 100)Remaining amount (to 100) 실시예3-52Example 3-52 0.040.04 0.10.1 0.040.04 잔량(to 100)Remaining amount (to 100) 실시예3-53Example 3-53 0.040.04 0.10.1 0.020.02 잔량(to 100)Remaining amount (to 100) 실시예3-54Example 3-54 0.040.04 0.10.1 0.010.01 잔량(to 100)Remaining amount (to 100) 실시예3-55Example 3-55 0.040.04 0.040.04 0.040.04 잔량(to 100)Remaining amount (to 100) 실시예3-56Example 3-56 0.040.04 0.040.04 0.020.02 잔량(to 100)Remaining amount (to 100) 실시예3-57Example 3-57 0.040.04 0.040.04 0.010.01 잔량(to 100)Remaining amount (to 100) 실시예3-58Example 3-58 0.040.04 0.0010.001 0.040.04 잔량(to 100)Remaining amount (to 100) 실시예3-59Example 3-59 0.040.04 0.0010.001 0.020.02 잔량(to 100)Remaining amount (to 100) 실시예3-60Example 3-60 0.040.04 0.0010.001 0.010.01 잔량(to 100)Remaining amount (to 100) 실시예3-61Example 3-61 0.0010.001 3030 0.040.04 잔량(to 100)Remaining amount (to 100) 실시예3-62Example 3-62 0.0010.001 3030 0.020.02 잔량(to 100)Remaining amount (to 100) 실시예3-63Example 3-63 0.0010.001 3030 0.010.01 잔량(to 100)Remaining amount (to 100) 실시예3-64Example 3-64 0.0010.001 0.50.5 0.040.04 잔량(to 100)Remaining amount (to 100) 실시예3-65Example 3-65 0.0010.001 0.50.5 0.020.02 잔량(to 100)Remaining amount (to 100) 실시예3-66Example 3-66 0.0010.001 0.50.5 0.010.01 잔량(to 100)Remaining amount (to 100) 실시예3-67Example 3-67 0.0010.001 0.10.1 0.040.04 잔량(to 100)Remaining amount (to 100) 실시예3-68Example 3-68 0.0010.001 0.10.1 0.020.02 잔량(to 100)Remaining amount (to 100) 실시예3-69Example 3-69 0.0010.001 0.10.1 0.010.01 잔량(to 100)Remaining amount (to 100) 실시예3-70Example 3-70 0.0010.001 0.040.04 0.040.04 잔량(to 100)Remaining amount (to 100) 실시예3-71Example 3-71 0.0010.001 0.040.04 0.020.02 잔량(to 100)Remaining amount (to 100) 실시예3-72Example 3-72 0.0010.001 0.040.04 0.010.01 잔량(to 100)Remaining amount (to 100) 실시예3-73Example 3-73 0.0010.001 0.0010.001 0.040.04 잔량(to 100)Remaining amount (to 100) 실시예3-74Example 3-74 0.0010.001 0.0010.001 0.020.02 잔량(to 100)Remaining amount (to 100) 실시예3-75Example 3-75 0.0010.001 0.0010.001 0.010.01 잔량(to 100)Remaining amount (to 100)

표 4에 나타낸 실시예 4-1 내지 실시예 4-75는 4'-하이드록시아세토페논(4'-hydroxyacetophenone), 라우릴피리디늄클로라이드(laurylpyridinium chloride) 및 1,2-헥산디올(1,2-hexandiol)의 성분 및 함량을 하기 표 4에서와 같이 넣어 제조된 화장료 조성물이다.Examples 4-1 to Examples 4-75 shown in Table 4 are 4'-hydroxyacetophenone, laurylpyridinium chloride and 1,2-hexanediol (1,2) -hexandiol) is a cosmetic composition prepared by putting the ingredients and contents as shown in Table 4 below.

구분division 4'-HDP4'-HDP LPCLPC HXDHXD 정제수Purified water 중량%weight% 실시예4-1Example 4-1 3030 3030 0.040.04 잔량(to 100)Remaining amount (to 100) 실시예4-2Example 4-2 3030 3030 0.020.02 잔량(to 100)Remaining amount (to 100) 실시예4-3Example 4-3 3030 3030 0.010.01 잔량(to 100)Remaining amount (to 100) 실시예4-4Example 4-4 3030 0.50.5 0.040.04 잔량(to 100)Remaining amount (to 100) 실시예4-5Example 4-5 3030 0.50.5 0.020.02 잔량(to 100)Remaining amount (to 100) 실시예4-6Example 4-6 3030 0.50.5 0.010.01 잔량(to 100)Remaining amount (to 100) 실시예4-7Example 4-7 3030 0.10.1 0.040.04 잔량(to 100)Remaining amount (to 100) 실시예4-8Example 4-8 3030 0.10.1 0.020.02 잔량(to 100)Remaining amount (to 100) 실시예4-9Example 4-9 3030 0.10.1 0.010.01 잔량(to 100)Remaining amount (to 100) 실시예4-10Example 4-10 3030 0.040.04 0.040.04 잔량(to 100)Remaining amount (to 100) 실시예4-11Example 4-11 3030 0.040.04 0.020.02 잔량(to 100)Remaining amount (to 100) 실시예4-12Example 4-12 3030 0.040.04 0.010.01 잔량(to 100)Remaining amount (to 100) 실시예4-13Example 4-13 3030 0.0010.001 0.040.04 잔량(to 100)Remaining amount (to 100) 실시예4-14Example 4-14 3030 0.0010.001 0.020.02 잔량(to 100)Remaining amount (to 100) 실시예4-15Example 4-15 3030 0.0010.001 0.010.01 잔량(to 100)Remaining amount (to 100) 실시예4-16Example 4-16 0.50.5 3030 0.040.04 잔량(to 100)Remaining amount (to 100) 실시예4-17Example 4-17 0.50.5 3030 0.020.02 잔량(to 100)Remaining amount (to 100) 실시예4-18Example 4-18 0.50.5 3030 0.010.01 잔량(to 100)Remaining amount (to 100) 실시예4-19Example 4-19 0.50.5 0.50.5 0.040.04 잔량(to 100)Remaining amount (to 100) 실시예4-20Example 4-20 0.50.5 0.50.5 0.020.02 잔량(to 100)Remaining amount (to 100) 실시예4-21Example 4-21 0.50.5 0.50.5 0.010.01 잔량(to 100)Remaining amount (to 100) 실시예4-22Example 4-22 0.50.5 0.10.1 0.040.04 잔량(to 100)Remaining amount (to 100) 실시예4-23Example 4-23 0.50.5 0.10.1 0.020.02 잔량(to 100)Remaining amount (to 100) 실시예4-24Example 4-24 0.50.5 0.10.1 0.010.01 잔량(to 100)Remaining amount (to 100) 실시예4-25Example 4-25 0.50.5 0.040.04 0.040.04 잔량(to 100)Remaining amount (to 100) 실시예4-26Example 4-26 0.50.5 0.040.04 0.020.02 잔량(to 100)Remaining amount (to 100) 실시예4-27Example 4-27 0.50.5 0.040.04 0.010.01 잔량(to 100)Remaining amount (to 100) 실시예4-28Example 4-28 0.50.5 0.0010.001 0.040.04 잔량(to 100)Remaining amount (to 100) 실시예4-29Example 4-29 0.50.5 0.0010.001 0.020.02 잔량(to 100)Remaining amount (to 100) 실시예4-30Example 4-30 0.50.5 0.0010.001 0.010.01 잔량(to 100)Remaining amount (to 100) 실시예4-31Example 4-31 0.10.1 3030 0.040.04 잔량(to 100)Remaining amount (to 100) 실시예4-32Example 4-32 0.10.1 3030 0.020.02 잔량(to 100)Remaining amount (to 100) 실시예4-33Example 4-33 0.10.1 3030 0.010.01 잔량(to 100)Remaining amount (to 100) 실시예4-34Example 4-34 0.10.1 0.50.5 0.040.04 잔량(to 100)Remaining amount (to 100) 실시예4-35Example 4-35 0.10.1 0.50.5 0.020.02 잔량(to 100)Remaining amount (to 100) 실시예4-36Example 4-36 0.10.1 0.50.5 0.010.01 잔량(to 100)Remaining amount (to 100) 실시예4-37Example 4-37 0.10.1 0.10.1 0.040.04 잔량(to 100)Remaining amount (to 100) 실시예4-38Example 4-38 0.10.1 0.10.1 0.020.02 잔량(to 100)Remaining amount (to 100) 실시예4-39Example 4-39 0.10.1 0.10.1 0.010.01 잔량(to 100)Remaining amount (to 100) 실시예4-40Example 4-40 0.10.1 0.040.04 0.040.04 잔량(to 100)Remaining amount (to 100) 실시예4-41Example 4-41 0.10.1 0.040.04 0.020.02 잔량(to 100)Remaining amount (to 100) 실시예4-42Example 4-42 0.10.1 0.040.04 0.010.01 잔량(to 100)Remaining amount (to 100) 실시예4-43Example 4-43 0.10.1 0.0010.001 0.040.04 잔량(to 100)Remaining amount (to 100) 실시예4-44Example 4-44 0.10.1 0.0010.001 0.020.02 잔량(to 100)Remaining amount (to 100) 실시예4-45Example 4-45 0.10.1 0.0010.001 0.010.01 잔량(to 100)Remaining amount (to 100) 실시예4-46Example 4-46 0.040.04 3030 0.040.04 잔량(to 100)Remaining amount (to 100) 실시예4-47Example 4-47 0.040.04 3030 0.020.02 잔량(to 100)Remaining amount (to 100) 실시예4-48Example 4-48 0.040.04 3030 0.010.01 잔량(to 100)Remaining amount (to 100) 실시예4-49Example 4-49 0.040.04 0.50.5 0.040.04 잔량(to 100)Remaining amount (to 100) 실시예4-50Example 4-50 0.040.04 0.50.5 0.020.02 잔량(to 100)Remaining amount (to 100) 실시예4-51Example 4-51 0.040.04 0.50.5 0.010.01 잔량(to 100)Remaining amount (to 100) 실시예4-52Example 4-52 0.040.04 0.10.1 0.040.04 잔량(to 100)Remaining amount (to 100) 실시예4-53Example 4-53 0.040.04 0.10.1 0.020.02 잔량(to 100)Remaining amount (to 100) 실시예4-54Example 4-54 0.040.04 0.10.1 0.010.01 잔량(to 100)Remaining amount (to 100) 실시예4-55Example 4-55 0.040.04 0.040.04 0.040.04 잔량(to 100)Remaining amount (to 100) 실시예4-56Example 4-56 0.040.04 0.040.04 0.020.02 잔량(to 100)Remaining amount (to 100) 실시예4-57Example 4-57 0.040.04 0.040.04 0.010.01 잔량(to 100)Remaining amount (to 100) 실시예4-58Example 4-58 0.040.04 0.0010.001 0.040.04 잔량(to 100)Remaining amount (to 100) 실시예4-59Example 4-59 0.040.04 0.0010.001 0.020.02 잔량(to 100)Remaining amount (to 100) 실시예4-60Example 4-60 0.040.04 0.0010.001 0.010.01 잔량(to 100)Remaining amount (to 100) 실시예4-61Example 4-61 0.0010.001 3030 0.040.04 잔량(to 100)Remaining amount (to 100) 실시예4-62Example 4-62 0.0010.001 3030 0.020.02 잔량(to 100)Remaining amount (to 100) 실시예4-63Example 4-63 0.0010.001 3030 0.010.01 잔량(to 100)Remaining amount (to 100) 실시예4-64Example 4-64 0.0010.001 0.50.5 0.040.04 잔량(to 100)Remaining amount (to 100) 실시예4-65Example 4-65 0.0010.001 0.50.5 0.020.02 잔량(to 100)Remaining amount (to 100) 실시예4-66Example 4-66 0.0010.001 0.50.5 0.010.01 잔량(to 100)Remaining amount (to 100) 실시예4-67Example 4-67 0.0010.001 0.10.1 0.040.04 잔량(to 100)Remaining amount (to 100) 실시예4-68Example 4-68 0.0010.001 0.10.1 0.020.02 잔량(to 100)Remaining amount (to 100) 실시예4-69Example 4-69 0.0010.001 0.10.1 0.010.01 잔량(to 100)Remaining amount (to 100) 실시예4-70Example 4-70 0.0010.001 0.040.04 0.040.04 잔량(to 100)Remaining amount (to 100) 실시예4-71Example 4-71 0.0010.001 0.040.04 0.020.02 잔량(to 100)Remaining amount (to 100) 실시예4-72Example 4-72 0.0010.001 0.040.04 0.010.01 잔량(to 100)Remaining amount (to 100) 실시예4-73Example 4-73 0.0010.001 0.0010.001 0.040.04 잔량(to 100)Remaining amount (to 100) 실시예4-74Example 4-74 0.0010.001 0.0010.001 0.020.02 잔량(to 100)Remaining amount (to 100) 실시예4-75Example 4-75 0.0010.001 0.0010.001 0.010.01 잔량(to 100)Remaining amount (to 100)

상기 실시예에서 제조된 화장료 조성물의 항균 활성을 확인하였으며, 그 결과는 하기 표 5 내지 표 8에 나타내었다.The antibacterial activity of the cosmetic composition prepared in the above Example was confirmed, and the results are shown in Tables 5 to 8 below.

구체적으로 본 발명의 화장료 조성물의 항균 활성 실험은 U. S. Pharmacopoeia 기준에 따라 수행하였으며, 균의 감소 및 사멸 정도를 확인하기 위해 평판 배양법으로 실험하였다.Specifically, the antibacterial activity experiment of the cosmetic composition of the present invention was performed according to the U. S. Pharmacopoeia standard, and tested by a plate culture method to confirm the reduction and killing of bacteria.

항균 활성에 사용된 세균, 진균 곰팡이는 한국생명공학연구원 생물자원센터(KCTC)로부터 분양 받았으며, 세균은 대장균(Escherichia coli; 균주번호 2571), 황색포도상구균(Staphylococcus aureus; 균주번호 3881), 녹농균(Pseudomonas aeruginosa; 균주번호 2513)이 혼합된 균을 이용하고, 진균은 칸디다 알비칸스(Candida albicans; 균주번호 7965) 균이며, 곰팡이는 아스페르질루스 나이거(Aspergillus niger; 균주번호 6089) 균을 이용하여 항균 활성을 확인하였다.Bacterial, fungal mold have received pre-sale from the Korea Research Institute of Bioscience and Biotechnology Biological Resource Center (KCTC), the bacteria E. coli using the antibacterial activity (Escherichia coli; strain No. 2571), Staphylococcus aureus (Staphylococcus aureus; strain No. 3881), Pseudomonas aeruginosa ( Pseudomonas aeruginosa; strain No. 2513) are using the mixed bacteria, fungi Candida albicans (Candida albicans; and strain number 7965), bacteria, fungus Aspergillus and this (Aspergillus niger; strain No. 6089) using the fungus Antibacterial activity was confirmed.

상기 실시예에서 제조된 화장료 조성물에 각각의 균 배양액을 접종하고, 세균은 TSA(Tryptic Soy Agar) 평판 배제에 배양하고, 진균인 칸디다 알비칸스와 곰팡이인 아스페르질루스 나이거는 PDA(Potato Dextrose Agar) 평판 배지에 도포한 후 30℃내지 35℃ 온도의 배양기(incubator)에서 배양한 후, 배양된다.Each of the fungal cultures was inoculated into the cosmetic composition prepared in the above Example, and the bacteria were cultured on a TSA (Tryptic Soy Agar) plate exclusion, and the fungus Candida albicans and the fungus Aspergillus niger were PDAs (Potato Dextrose Agar). ) After being applied to the plate medium, cultured in an incubator at a temperature of 30°C to 35°C, and then cultured.

상기 실시예에서 제조된 화장료 조성물의 항균 활성을 확인하였으며, 그 결과는 하기 표 5 내지 표 8에 나타내었다.The antibacterial activity of the cosmetic composition prepared in the above Example was confirmed, and the results are shown in Tables 5 to 8 below.

구체적으로 본 발명의 화장료 조성물의 항균 활성 실험은 U. S. Pharmacopoeia 기준에 따라 수행하였으며, 균의 감소 및 사멸 정도를 확인하기 위해 평판 배양법으로 실험하였다.Specifically, the antibacterial activity experiment of the cosmetic composition of the present invention was performed according to the U. S. Pharmacopoeia standard, and tested by a plate culture method to confirm the reduction and killing of bacteria.

항균 활성에 사용된 세균, 진균 곰팡이는 한국생명공학연구원 생물자원센터(KCTC)로부터 분양 받았으며, 세균은 대장균(Escherichia coli; 균주번호 2571), 황색포도상구균(Staphylococcus aureus; 균주번호 3881), 녹농균(Pseudomonas aeruginosa; 균주번호 2513)이 혼합된 균을 이용하고, 진균은 칸디다 알비칸스(Candida albicans; 균주번호 7965) 균이며, 곰팡이는 아스페르질루스 나이거(Aspergillus niger; 균주번호 6089) 균을 이용하여 항균 활성을 확인하였다.The bacteria and fungi used for antibacterial activity were pre-sold by the Korea Research Institute of Bioscience and Biotechnology (KCTC) and the bacteria were Escherichia coli ; Strain No. 2571), Staphylococcus aureus (Staphylococcus aureus; Strain No. 3881), Pseudomonas aeruginosa (Pseudomonas aeruginosa ; Strain No. 2513) are using the mixed bacteria, fungi Candida albicans (Candida albicans; and strain number 7965), bacteria, fungus Aspergillus and this (Aspergillus niger; strain No. 6089) antimicrobial activity using the fungus Was confirmed.

상기 실시예에서 제조된 화장료 조성물에 각각의 균 배양액을 접종하고, 세균은 TSA(Tryptic Soy Agar) 평판 배제에 배양하고, 진균인 칸디다 알비칸스와 곰팡이인 아스페르질루스 나이거는 PDA(Potato Dextrose Agar) 평판 배지에 도포한 후 30℃내지 35℃ 온도의 배양기(incubator)에서 배양한 후, 배양된다.Each of the fungal cultures was inoculated into the cosmetic composition prepared in the above Example, and the bacteria were cultured on a TSA (Tryptic Soy Agar) plate exclusion, and the fungus Candida albicans and the fungus Aspergillus niger were PDAs (Potato Dextrose Agar). ) After being applied to the plate medium, cultured in an incubator at a temperature of 30°C to 35°C, and then cultured.

하기 표 5 내지 표 8에 기재된 '○'와 'X'는 균의 사멸 여부를 표시한 것으로 대조군의 접종균수와 비교하여 아래 계산식 1과 같이 계산된 균의 사멸율이 99.9% 이상이면 '○'로 나타내고, 균의 사멸율이 99.9% 미만이면 'X'로 나타내었다. 여기서 대조군이란 실시예의 화장료 조성물 대신에 증류수에 균 배양액을 접종한 것이다.'○' and'X' shown in Tables 5 to 8 below indicate whether or not the bacteria are killed. It is represented by, and if the mortality rate of the bacteria is less than 99.9%, it is represented by'X'. Here, the control group is inoculated with the bacterial culture solution in distilled water instead of the cosmetic composition of the embodiment.

[계산식 1][Calculation formula 1]

균의 사멸률(%)=((대조군의 접종균수-실시예의 잔존균수)/대조군의 접종균수)×100Killing rate of bacteria (%) = ((number of inoculation bacteria in the control group-number of remaining bacteria in the example) / number of inoculation bacteria in the control group) × 100

조성물Composition 세균Germ 진균Fungi 곰팡이mold 조성물Composition 세균Germ 진균Fungi 곰팡이mold 실시예1-1Example 1-1 ○○ ○○ ○○ 실시예1-39Example 1-39 ○○ ○○ ○○ 실시예1-2Example 1-2 ○○ ○○ ○○ 실시예1-40Example 1-40 ○○ ○○ ○○ 실시예1-3Example 1-3 ○○ ○○ ○○ 실시예1-41Example 1-41 ○○ ○○ ○○ 실시예1-4Example 1-4 ○○ ○○ ○○ 실시예1-42Example 1-42 ○○ ○○ ○○ 실시예1-5Example 1-5 ○○ ○○ ○○ 실시예1-43Example 1-43 XX XX XX 실시예1-6Example 1-6 ○○ ○○ ○○ 실시예1-44Example 1-44 XX XX XX 실시예1-7Example 1-7 ○○ ○○ ○○ 실시예1-45Example 1-45 XX XX XX 실시예1-8Example 1-8 ○○ ○○ ○○ 실시예1-46Example 1-46 ○○ ○○ ○○ 실시예1-9Example 1-9 ○○ ○○ ○○ 실시예1-47Example 1-47 ○○ ○○ ○○ 실시예1-10Example 1-10 ○○ ○○ ○○ 실시예1-48Example 1-48 ○○ ○○ ○○ 실시예1-11Example 1-11 ○○ ○○ ○○ 실시예1-49Example 1-49 ○○ ○○ ○○ 실시예1-12Example 1-12 ○○ ○○ ○○ 실시예1-50Example 1-50 ○○ ○○ ○○ 실시예1-13Example 1-13 ○○ ○○ ○○ 실시예1-51Example 1-51 ○○ ○○ ○○ 실시예1-14Example 1-14 ○○ ○○ ○○ 실시예1-52Example 1-52 ○○ ○○ ○○ 실시예1-15Example 1-15 ○○ ○○ ○○ 실시예1-53Example 1-53 ○○ ○○ ○○ 실시예1-16Example 1-16 ○○ ○○ ○○ 실시예1-54Example 1-54 ○○ ○○ ○○ 실시예1-17Example 1-17 ○○ ○○ ○○ 실시예1-55Example 1-55 XX XX XX 실시예1-18Example 1-18 ○○ ○○ ○○ 실시예1-56Example 1-56 XX XX XX 실시예1-19Example 1-19 ○○ ○○ ○○ 실시예1-57Example 1-57 XX XX XX 실시예1-20Example 1-20 ○○ ○○ ○○ 실시예1-58Example 1-58 XX XX XX 실시예1-21Example 1-21 ○○ ○○ ○○ 실시예1-59Example 1-59 XX XX XX 실시예1-22Example 1-22 ○○ ○○ ○○ 실시예1-60Example 1-60 XX XX XX 실시예1-23Example 1-23 ○○ ○○ ○○ 실시예1-61Example 1-61 ○○ ○○ ○○ 실시예1-24Example 1-24 ○○ ○○ ○○ 실시예1-62Example 1-62 ○○ ○○ ○○ 실시예1-25Example 1-25 ○○ ○○ ○○ 실시예1-63Example 1-63 ○○ ○○ ○○ 실시예1-26Example 1-26 ○○ ○○ ○○ 실시예1-64Example 1-64 ○○ ○○ ○○ 실시예1-27Example 1-27 ○○ ○○ ○○ 실시예1-65Example 1-65 ○○ ○○ ○○ 실시예1-28Example 1-28 ○○ ○○ ○○ 실시예1-66Example 1-66 ○○ ○○ ○○ 실시예1-29Example 1-29 ○○ ○○ ○○ 실시예1-67Example 1-67 ○○ ○○ ○○ 실시예1-30Example 1-30 ○○ ○○ ○○ 실시예1-68Example 1-68 ○○ ○○ ○○ 실시예1-31Example 1-31 ○○ ○○ ○○ 실시예1-69Example 1-69 ○○ ○○ ○○ 실시예1-32Example 1-32 ○○ ○○ ○○ 실시예1-70Example 1-70 XX XX XX 실시예1-33Example 1-33 ○○ ○○ ○○ 실시예1-71Example 1-71 XX XX XX 실시예1-34Example 1-34 ○○ ○○ ○○ 실시예1-72Example 1-72 XX XX XX 실시예1-35Example 1-35 ○○ ○○ ○○ 실시예1-73Example 1-73 XX XX XX 실시예1-36Example 1-36 ○○ ○○ ○○ 실시예1-74Example 1-74 XX XX XX 실시예1-37Example 1-37 ○○ ○○ ○○ 실시예1-75Example 1-75 XX XX XX 실시예1-38Example 1-38 ○○ ○○ ○○

상기 표 5에서와 같이 유기산으로 소듐데하이드로아세테이트(sodium dehydroacetate)를 포함하는 화장료 조성물로 실시예 1-43 내지 실시예 1-45, 실시예 1-58 내지 실시예 1-60, 실시예 1-72 내지 실시예 1-75와 같은 화장료 조성물에서 4'-하이드록시아세토페논의 함량을 각각 0.1 중량%, 0.04 중량%, 0.001 중량%로 포함하고 라우릴피리디늄클로라이드(laurylpyridinium chloride)의 함량을 0.001중량%로 포함하는 경우에서는 세균, 진균 및 곰팡이 모두에서 균의 사멸율이 99.9% 미만이 되므로 항균 효율을 만족하지 못하는 것을 알 수 있다.Cosmetic compositions containing sodium dehydroacetate as an organic acid as in Table 5 above, Examples 1-43 to 1-45, Examples 1-58 to 1-60, and Example 1- In the cosmetic composition such as 72 to Examples 1-75, the content of 4'-hydroxyacetophenone is 0.1 wt%, 0.04 wt%, and 0.001 wt%, respectively, and the content of laurylpyridinium chloride is 0.001. In the case of containing by weight%, it can be seen that the killing rate of the bacteria is less than 99.9% in both bacteria, fungi, and fungi, and thus it is found that the antibacterial efficiency is not satisfied.

조성물Composition 세균Germ 진균Fungi 곰팡이mold 조성물Composition 세균Germ 진균Fungi 곰팡이mold 실시예2-1Example 2-1 ○○ ○○ ○○ 실시예2-39Example 2-39 ○○ ○○ ○○ 실시예2-2Example 2-2 ○○ ○○ ○○ 실시예2-40Example 2-40 ○○ ○○ ○○ 실시예2-3Example 2-3 ○○ ○○ ○○ 실시예2-41Example 2-41 ○○ ○○ ○○ 실시예2-4Example 2-4 ○○ ○○ ○○ 실시예2-42Example 2-42 ○○ ○○ ○○ 실시예2-5Example 2-5 ○○ ○○ ○○ 실시예2-43Example 2-43 XX XX XX 실시예2-6Example 2-6 ○○ ○○ ○○ 실시예2-44Example 2-44 XX XX XX 실시예2-7Example 2-7 ○○ ○○ ○○ 실시예2-45Example 2-45 XX XX XX 실시예2-8Example 2-8 ○○ ○○ ○○ 실시예2-46Example 2-46 ○○ ○○ ○○ 실시예2-9Example 2-9 ○○ ○○ ○○ 실시예2-47Example 2-47 ○○ ○○ ○○ 실시예2-10Example 2-10 ○○ ○○ ○○ 실시예2-48Example 2-48 ○○ ○○ ○○ 실시예2-11Example 2-11 ○○ ○○ ○○ 실시예2-49Example 2-49 ○○ ○○ ○○ 실시예2-12Example 2-12 ○○ ○○ ○○ 실시예2-50Example 2-50 ○○ ○○ ○○ 실시예2-13Example 2-13 ○○ ○○ ○○ 실시예2-51Example 2-51 ○○ ○○ ○○ 실시예2-14Example 2-14 ○○ ○○ ○○ 실시예2-52Example 2-52 ○○ ○○ ○○ 실시예2-15Example 2-15 ○○ ○○ ○○ 실시예2-53Example 2-53 ○○ ○○ ○○ 실시예2-16Example 2-16 ○○ ○○ ○○ 실시예2-54Example 2-54 ○○ ○○ ○○ 실시예2-17Example 2-17 ○○ ○○ ○○ 실시예2-55Example 2-55 XX XX XX 실시예2-18Example 2-18 ○○ ○○ ○○ 실시예2-56Example 2-56 XX XX XX 실시예2-19Example 2-19 ○○ ○○ ○○ 실시예2-57Example 2-57 XX XX XX 실시예2-20Example 2-20 ○○ ○○ ○○ 실시예2-58Example 2-58 XX XX XX 실시예2-21Example 2-21 ○○ ○○ ○○ 실시예2-59Example 2-59 XX XX XX 실시예2-22Example 2-22 ○○ ○○ ○○ 실시예2-60Example 2-60 XX XX XX 실시예2-23Example 2-23 ○○ ○○ ○○ 실시예2-61Example 2-61 ○○ ○○ ○○ 실시예2-24Example 2-24 ○○ ○○ ○○ 실시예2-62Example 2-62 ○○ ○○ ○○ 실시예2-25Example 2-25 ○○ ○○ ○○ 실시예2-63Example 2-63 ○○ ○○ ○○ 실시예2-26Example 2-26 ○○ ○○ ○○ 실시예2-64Example 2-64 ○○ ○○ ○○ 실시예2-27Example 2-27 ○○ ○○ ○○ 실시예2-65Example 2-65 ○○ ○○ ○○ 실시예2-28Example 2-28 ○○ ○○ ○○ 실시예2-66Example 2-66 ○○ ○○ ○○ 실시예2-29Example 2-29 ○○ ○○ ○○ 실시예2-67Example 2-67 ○○ ○○ ○○ 실시예2-30Example 2-30 ○○ ○○ ○○ 실시예2-68Example 2-68 ○○ ○○ ○○ 실시예2-31Example 2-31 ○○ ○○ ○○ 실시예2-69Example 2-69 ○○ ○○ ○○ 실시예2-32Example 2-32 ○○ ○○ ○○ 실시예2-70Example 2-70 XX XX XX 실시예2-33Example 2-33 ○○ ○○ ○○ 실시예2-71Example 2-71 XX XX XX 실시예2-34Example 2-34 ○○ ○○ ○○ 실시예2-72Example 2-72 XX XX XX 실시예2-35Example 2-35 ○○ ○○ ○○ 실시예2-73Example 2-73 XX XX XX 실시예2-36Example 2-36 ○○ ○○ ○○ 실시예2-74Example 2-74 XX XX XX 실시예2-37Example 2-37 ○○ ○○ ○○ 실시예2-75Example 2-75 XX XX XX 실시예2-38Example 2-38 ○○ ○○ ○○

상기 표 6에서와 같이 카프릴하이드록사믹산(caprylhydroxamic acid)을 포함하는 화장료 조성물로 실시예 2-43 내지 실시예 2-45, 실시예 2-58 내지 실시예 2-60, 실시예 2-72 내지 실시예 2-75와 같은 화장료 조성물에서 4'-하이드록시아세토페논의 함량을 각각 0.1 중량%, 0.04 중량%, 0.001 중량%로 포함하고 라우릴피리디늄클로라이드(laurylpyridinium chloride)의 함량을 0.001중량%로 포함하는 경우에서는 세균, 진균 및 곰팡이 모두에서 균의 사멸율이 99.9% 미만이 되므로 항균 효율을 만족하지 못하는 것을 알 수 있다.Cosmetic composition containing caprylhydroxamic acid as in Table 6 above, Examples 2-43 to Example 2-45, Examples 2-58 to Examples 2-60, Examples 2-72 In the cosmetic composition as in Example 2-75, the content of 4'-hydroxyacetophenone is 0.1 wt%, 0.04 wt%, and 0.001 wt%, respectively, and the content of laurylpyridinium chloride is 0.001 wt. In the case of %, it can be seen that the bacterial kill rate is less than 99.9% in both bacteria, fungi, and fungi, so that it cannot satisfy the antibacterial efficiency.

조성물Composition 세균Germ 진균Fungi 곰팡이mold 조성물Composition 세균Germ 진균Fungi 곰팡이mold 실시예3-1Example 3-1 ○○ ○○ ○○ 실시예3-39Example 3-39 ○○ ○○ ○○ 실시예3-2Example 3-2 ○○ ○○ ○○ 실시예3-40Example 3-40 ○○ ○○ ○○ 실시예3-3Example 3-3 ○○ ○○ ○○ 실시예3-41Example 3-41 ○○ ○○ ○○ 실시예3-4Example 3-4 ○○ ○○ ○○ 실시예3-42Example 3-42 ○○ ○○ ○○ 실시예3-5Example 3-5 ○○ ○○ ○○ 실시예3-43Example 3-43 XX XX XX 실시예3-6Example 3-6 ○○ ○○ ○○ 실시예3-44Example 3-44 XX XX XX 실시예3-7Example 3-7 ○○ ○○ ○○ 실시예3-45Example 3-45 XX XX XX 실시예3-8Example 3-8 ○○ ○○ ○○ 실시예3-46Example 3-46 ○○ ○○ ○○ 실시예3-9Example 3-9 ○○ ○○ ○○ 실시예3-47Example 3-47 ○○ ○○ ○○ 실시예3-10Example 3-10 ○○ ○○ ○○ 실시예3-48Example 3-48 ○○ ○○ ○○ 실시예3-11Example 3-11 ○○ ○○ ○○ 실시예3-49Example 3-49 ○○ ○○ ○○ 실시예3-12Example 3-12 ○○ ○○ ○○ 실시예3-50Example 3-50 ○○ ○○ ○○ 실시예3-13Example 3-13 ○○ ○○ ○○ 실시예3-51Example 3-51 ○○ ○○ ○○ 실시예3-14Example 3-14 ○○ ○○ ○○ 실시예3-52Example 3-52 ○○ ○○ ○○ 실시예3-15Example 3-15 ○○ ○○ ○○ 실시예3-53Example 3-53 ○○ ○○ ○○ 실시예3-16Example 3-16 ○○ ○○ ○○ 실시예3-54Example 3-54 ○○ ○○ ○○ 실시예3-17Example 3-17 ○○ ○○ ○○ 실시예3-55Example 3-55 XX XX XX 실시예3-18Example 3-18 ○○ ○○ ○○ 실시예3-56Example 3-56 XX XX XX 실시예3-19Example 3-19 ○○ ○○ ○○ 실시예3-57Example 3-57 XX XX XX 실시예3-20Example 3-20 ○○ ○○ ○○ 실시예3-58Example 3-58 XX XX XX 실시예3-21Example 3-21 ○○ ○○ ○○ 실시예3-59Example 3-59 XX XX XX 실시예3-22Example 3-22 ○○ ○○ ○○ 실시예3-60Example 3-60 XX XX XX 실시예3-23Example 3-23 ○○ ○○ ○○ 실시예3-61Example 3-61 ○○ ○○ ○○ 실시예3-24Example 3-24 ○○ ○○ ○○ 실시예3-62Example 3-62 ○○ ○○ ○○ 실시예3-25Example 3-25 ○○ ○○ ○○ 실시예3-63Example 3-63 ○○ ○○ ○○ 실시예3-26Example 3-26 ○○ ○○ ○○ 실시예3-64Example 3-64 ○○ ○○ ○○ 실시예3-27Example 3-27 ○○ ○○ ○○ 실시예3-65Example 3-65 ○○ ○○ ○○ 실시예3-28Example 3-28 ○○ ○○ ○○ 실시예3-66Example 3-66 ○○ ○○ ○○ 실시예3-29Example 3-29 ○○ ○○ ○○ 실시예3-67Example 3-67 ○○ ○○ ○○ 실시예3-30Example 3-30 ○○ ○○ ○○ 실시예3-68Example 3-68 ○○ ○○ ○○ 실시예3-31Example 3-31 ○○ ○○ ○○ 실시예3-69Example 3-69 ○○ ○○ ○○ 실시예3-32Example 3-32 ○○ ○○ ○○ 실시예3-70Example 3-70 XX XX XX 실시예3-33Example 3-33 ○○ ○○ ○○ 실시예3-71Example 3-71 XX XX XX 실시예3-34Example 3-34 ○○ ○○ ○○ 실시예3-72Example 3-72 XX XX XX 실시예3-35Example 3-35 ○○ ○○ ○○ 실시예3-73Example 3-73 XX XX XX 실시예3-36Example 3-36 ○○ ○○ ○○ 실시예3-74Example 3-74 XX XX XX 실시예3-37Example 3-37 ○○ ○○ ○○ 실시예3-75Example 3-75 XX XX XX 실시예3-38Example 3-38 ○○ ○○ ○○

상기 표 7에서와 같이 유기산으로 소듐벤조에이트(sodium benzoate)를 포함하는 화장료 조성물로 실시예 3-43 내지 실시예 3-45, 실시예 3-58 내지 실시예 3-60, 실시예 3-72 내지 실시예 3-75와 같은 화장료 조성물에서 4'-하이드록시아세토페논의 함량을 각각 0.1 중량%, 0.04 중량%, 0.001 중량%로 포함하고 라우릴피리디늄클로라이드(laurylpyridinium chloride)의 함량을 0.001중량%로 포함하는 경우에서는 세균, 진균 및 곰팡이 모두에서 균의 사멸율이 99.9% 미만이 되므로 항균 효율을 만족하지 못하는 것을 알 수 있다.Cosmetic composition containing sodium benzoate as an organic acid, as shown in Table 7, Examples 3-43 to Example 3-45, Examples 3-58 to 3-60, and Example 3-72 In the cosmetic composition as in Example 3-75, the content of 4'-hydroxyacetophenone is 0.1% by weight, 0.04% by weight, and 0.001% by weight, respectively, and the content of laurylpyridinium chloride is 0.001% by weight. In the case of %, it can be seen that the bacterial kill rate is less than 99.9% in both bacteria, fungi, and fungi, so that it cannot satisfy the antibacterial efficiency.

조성물Composition 세균Germ 진균Fungi 곰팡이mold 조성물Composition 세균Germ 진균Fungi 곰팡이mold 실시예4-1Example 4-1 ○○ ○○ ○○ 실시예4-39Example 4-39 ○○ ○○ ○○ 실시예4-2Example 4-2 ○○ ○○ ○○ 실시예4-40Example 4-40 ○○ ○○ ○○ 실시예4-3Example 4-3 ○○ ○○ ○○ 실시예4-41Example 4-41 ○○ ○○ ○○ 실시예4-4Example 4-4 ○○ ○○ ○○ 실시예4-42Example 4-42 ○○ ○○ ○○ 실시예4-5Example 4-5 ○○ ○○ ○○ 실시예4-43Example 4-43 XX XX XX 실시예4-6Example 4-6 ○○ ○○ ○○ 실시예4-44Example 4-44 XX XX XX 실시예4-7Example 4-7 ○○ ○○ ○○ 실시예4-45Example 4-45 XX XX XX 실시예4-8Example 4-8 ○○ ○○ ○○ 실시예4-46Example 4-46 ○○ ○○ ○○ 실시예4-9Example 4-9 ○○ ○○ ○○ 실시예4-47Example 4-47 ○○ ○○ ○○ 실시예4-10Example 4-10 ○○ ○○ ○○ 실시예4-48Example 4-48 ○○ ○○ ○○ 실시예4-11Example 4-11 ○○ ○○ ○○ 실시예4-49Example 4-49 ○○ ○○ ○○ 실시예4-12Example 4-12 ○○ ○○ ○○ 실시예4-50Example 4-50 ○○ ○○ ○○ 실시예4-13Example 4-13 ○○ ○○ ○○ 실시예4-51Example 4-51 ○○ ○○ ○○ 실시예4-14Example 4-14 ○○ ○○ ○○ 실시예4-52Example 4-52 ○○ ○○ ○○ 실시예4-15Example 4-15 ○○ ○○ ○○ 실시예4-53Example 4-53 ○○ ○○ ○○ 실시예4-16Example 4-16 ○○ ○○ ○○ 실시예4-54Example 4-54 ○○ ○○ ○○ 실시예4-17Example 4-17 ○○ ○○ ○○ 실시예4-55Example 4-55 XX XX XX 실시예4-18Example 4-18 ○○ ○○ ○○ 실시예4-56Example 4-56 XX XX XX 실시예4-19Example 4-19 ○○ ○○ ○○ 실시예4-57Example 4-57 XX XX XX 실시예4-20Example 4-20 ○○ ○○ ○○ 실시예4-58Example 4-58 XX XX XX 실시예4-21Example 4-21 ○○ ○○ ○○ 실시예4-59Example 4-59 XX XX XX 실시예4-22Example 4-22 ○○ ○○ ○○ 실시예4-60Example 4-60 XX XX XX 실시예4-23Example 4-23 ○○ ○○ ○○ 실시예4-61Example 4-61 ○○ ○○ ○○ 실시예4-24Example 4-24 ○○ ○○ ○○ 실시예4-62Example 4-62 ○○ ○○ ○○ 실시예4-25Example 4-25 ○○ ○○ ○○ 실시예4-63Example 4-63 ○○ ○○ ○○ 실시예4-26Example 4-26 ○○ ○○ ○○ 실시예4-64Example 4-64 ○○ ○○ ○○ 실시예4-27Example 4-27 ○○ ○○ ○○ 실시예4-65Example 4-65 ○○ ○○ ○○ 실시예4-28Example 4-28 ○○ ○○ ○○ 실시예4-66Example 4-66 ○○ ○○ ○○ 실시예4-29Example 4-29 ○○ ○○ ○○ 실시예4-67Example 4-67 ○○ ○○ ○○ 실시예4-30Example 4-30 ○○ ○○ ○○ 실시예4-68Example 4-68 ○○ ○○ ○○ 실시예4-31Example 4-31 ○○ ○○ ○○ 실시예4-69Example 4-69 ○○ ○○ ○○ 실시예4-32Example 4-32 ○○ ○○ ○○ 실시예4-70Example 4-70 XX XX XX 실시예4-33Example 4-33 ○○ ○○ ○○ 실시예4-71Example 4-71 XX XX XX 실시예4-34Example 4-34 ○○ ○○ ○○ 실시예4-72Example 4-72 XX XX XX 실시예4-35Example 4-35 ○○ ○○ ○○ 실시예4-73Example 4-73 XX XX XX 실시예4-36Example 4-36 ○○ ○○ ○○ 실시예4-74Example 4-74 XX XX XX 실시예4-37Example 4-37 ○○ ○○ ○○ 실시예4-75Example 4-75 XX XX XX 실시예4-38Example 4-38 ○○ ○○ ○○

상기 표 8에서와 같이 알킨디올로 1,2-헥산디올(hexandiol)을 포함하는 화장료 조성물로 실시예 4-43 내지 실시예 4-45, 실시예 4-58 내지 실시예 4-60, 실시예 4-72 내지 실시예 4-75와 같은 화장료 조성물에서 4'-하이드록시아세토페논의 함량을 각각 0.1 중량%, 0.04 중량%, 0.001 중량%로 포함하고 라우릴피리디늄클로라이드(laurylpyridinium chloride)의 함량을 0.001중량%로 포함하는 경우에서는 세균, 진균 및 곰팡이 모두에서 균의 사멸율이 99.9% 미만이 되므로 항균 효율을 만족하지 못하는 것을 알 수 있다.Cosmetic composition containing 1,2-hexanediol (hexandiol) as alkyndiol as in Table 8, Examples 4-43 to Example 4-45, Examples 4-58 to Examples 4-60, and Examples In the cosmetic composition such as 4-72 to Example 4-75, the content of 4'-hydroxyacetophenone is 0.1 wt%, 0.04 wt%, and 0.001 wt%, respectively, and the content of laurylpyridinium chloride In the case of containing 0.001% by weight, it can be seen that the killing rate of the bacteria is less than 99.9% in both bacteria, fungi, and fungi, and thus it is found that the antibacterial efficiency is not satisfied.

그러므로 본 발명의 화장료 조성물은 세균, 진균 및 곰팡이 모두에 대해 99.9% 이상의 균 사멸율을 갖는 항균 활성을 갖기 위해서는 4'-하이드록시아세토페논의 함량이 0.1 중량% 이하이면, 상기 라우릴피리디늄클로라이드(laurylpyridinium chloride)는 0.001중량% 초과하는 것으로 0.001중량% 초과 30 중량% 이하로 포함되는 것이 바람직하다.Therefore, the cosmetic composition of the present invention, if the content of 4'-hydroxyacetophenone is 0.1% by weight or less in order to have antibacterial activity having a bactericidal rate of 99.9% or more against all bacteria, fungi and fungi, the laurylpyridinium chloride (laurylpyridinium chloride) is more than 0.001% by weight, preferably more than 0.001% by weight and 30% by weight or less.

한편, 본 발명에서 사용되는 기술적 용어는 본 발명에서 특별히 다른 의미로 정의되지 않는 한, 본 발명의 속하는 기술 분야에서 통상의 지식을 가진 자에 의해 일반적으로 이해되는 의미로 해석되어야 하며, 과도하게 포괄적인 의미로 해석되거나, 과도하게 축소된 의미로 해석되지 않아야 한다. 또한, 본 발명에서 사용되는 일반적인 용어는 사전에 정의되어 있는 바에 따라, 또는 전후 문맥상에 따라 해석되어야 한다.Meanwhile, technical terms used in the present invention should be interpreted as meanings generally understood by a person having ordinary knowledge in the technical field to which the present invention pertains, unless otherwise defined in the present invention. It should not be interpreted as a meaning or an excessively reduced meaning. In addition, the general terms used in the present invention should be interpreted as defined in the dictionary or in context before and after.

또한, 본 발명에서 사용되는 단수의 표현은 문맥상 명백하게 다르게 뜻하지 않는 한, 복수의 표현을 포함한다. 본 명세서에서, '구성된다', '이루어진다' 또는 '포함한다' 등의 용어는 명세서 상에 기재된 여러 구성 요소들, 또는 여러 단계 들을 반드시 모두 포함하는 것으로 해석되지 않아야 하며, 그 중 일부 구성 요소들 또는 일부 단계들은 포함되지 않을 수도 있고, 또는 추가적인 구성 요소 또는 단계들을 더 포함할 수 있는 것으로 해석되어야 한다.In addition, the singular expression used in the present invention includes a plural expression unless the context clearly indicates otherwise. In the present specification, terms such as'consisting of','consisting of' or'comprising' are not to be construed as including all of the various elements or various steps described in the specification, and some of them. Or it should be construed that some steps may not be included, or may further include additional components or steps.

Claims (14)

삭제delete 4'-하이드록시아세토페논(4'-hydroxyacetophenone) 0.001 내지 30 중량%;
라우릴피리디늄클로라이드(laurylpyridinium chloride) 0.001 내지 30 중량%;
소듐데하이드로아세테이트(sodium dehydroacetate), 소듐벤조에이트(sodium benzoate), 카프릴하이드록사믹산(caprylhydroxamic acid) 및 알칸디올(alkanediol) 중에서 선택되는 어느 하나의 화합물 0.01 내지 0.04 중량%; 및
전체 조성물 총 중량이 100 중량%가 되도록 하는 잔량의 물;을 포함하며,
상기 4'-하이드록시아세토페논의 함량이 0.1 중량% 이하이면, 상기 라우릴피리디늄클로라이드(laurylpyridinium chloride)는 0.001중량% 초과 30 중량% 이하로 포함되는 것을 특징으로 하는 화장료 조성물.4'-hydroxyacetophenone (4'-hydroxyacetophenone) 0.001 to 30% by weight;
Laurylpyridinium chloride 0.001 to 30% by weight;
0.01 to 0.04% by weight of any one compound selected from sodium dehydroacetate, sodium benzoate, caprylhydroxamic acid and alkanediol; And
Contains the remaining amount of water so that the total weight of the total composition is 100% by weight,
If the content of the 4'-hydroxyacetophenone is 0.1% by weight or less, the laurylpyridinium chloride (laurylpyridinium chloride) is a cosmetic composition characterized in that it contains more than 0.001% by weight and 30% by weight or less. 삭제delete 제2항에 있어서,
상기 알칸디올은 옥탄디올(octandiol), 헥산디올(hexandiol) 및 프로판디올(propandiol) 중에서 선택되는 어느 하나 이상인 것을 특징으로 하는 화장료 조성물.According to claim 2,
The alkanediol cosmetic composition, characterized in that at least one selected from octadiol (octandiol), hexanediol (hexandiol) and propanediol (propandiol). 제2항에 있어서,
상기 화장료 조성물은,
클로르페네신(chlorphenesin) 및 트로폴론(tropolone) 중에서 선택되는 어느 하나 이상의 화합물을 포함하는 것을 특징으로 하는 화장료 조성물.According to claim 2,
The cosmetic composition,
Cosmetic composition comprising at least one compound selected from chlorphenesin and tropolone. 제5항에 있어서,
상기 클로르페네신(chlorphenesin) 및 트로폴론(tropolone) 중에서 선택되는 어느 하나 이상의 화합물은 조성물 총 중량에 대하여 1 내지 40 중량% 포함되는 것을 특징으로 하는 화장료 조성물.The method of claim 5,
The chlorphenesin (chlorphenesin) and any one or more compounds selected from tropolone (tropolone) cosmetic composition, characterized in that 1 to 40% by weight based on the total weight of the composition. 제2항에 있어서,
상기 화장료 조성물은 대장균(Escherichia coli), 포도상 구균(Staphyloccoccus aureus), 녹농균(Pseudomonas aeruginosa), 칸디다 알비칸스(Candida albicans) 및 아스퍼질러스 니거(Aspergillus niger) 모두에 대해 항균성을 가지는 것을 특징으로 하는 화장료 조성물.According to claim 2,
The cosmetic composition is characterized by having antimicrobial activity against Escherichia coli, Staphyloccoccus aureus, Pseudomonas aeruginosa, Candida albicans and Aspergillus niger Composition. 삭제delete 삭제delete 4'-하이드록시아세토페논(4'-hydroxyacetophenone) 0.001 내지 30 중량%; 라우릴피리디늄클로라이드(laurylpyridinium chloride) 0.001 내지 30 중량%; 소듐데하이드로아세테이트(sodium dehydroacetate), 소듐벤조에이트(sodium benzoate), 카프릴하이드록사믹산(caprylhydroxamic acid) 및 알칸디올(alkanediol) 중에서 선택되는 어느 하나의 화합물 0.01 내지 0.04 중량%; 및 전체 조성물 총 중량이 100 중량%가 되도록 하는 잔량의 물을 넣고 교반하여 화장료 조성물을 제조하는 단계;를 포함하되,
상기 4'-하이드록시아세토페논의 함량이 0.1 중량% 이하이면, 상기 라우릴피리디늄클로라이드(laurylpyridinium chloride)는 0.001중량% 초과 30 중량% 이하로 포함되는 것을 특징으로 하는 화장료 조성물 제조 방법.4'-hydroxyacetophenone (4'-hydroxyacetophenone) 0.001 to 30% by weight; Laurylpyridinium chloride 0.001 to 30% by weight; 0.01 to 0.04% by weight of any one compound selected from sodium dehydroacetate, sodium benzoate, caprylhydroxamic acid and alkanediol; And preparing a cosmetic composition by adding and stirring the remaining amount of water so that the total weight of the total composition is 100% by weight.
If the content of the 4'-hydroxyacetophenone is 0.1% by weight or less, the laurylpyridinium chloride (laurylpyridinium chloride) is 0.001% by weight of 30% by weight or less cosmetic composition manufacturing method characterized in that included. 삭제delete 제10항에 있어서,
상기 알칸디올(alkanediol)은 옥탄디올(octandiol), 헥산디올(hexandiol) 및 프로판디올(propandiol) 중에서 선택되는 어느 하나 이상인 것을 특징으로 하는 화장료 조성물 제조 방법.The method of claim 10,
The alkanediol (alkanediol) is an octanediol (octandiol), hexanediol (hexandiol) and propanediol (propandiol) selected from any one or more cosmetic composition manufacturing method characterized in that. 제10항에 있어서,
상기 화장료 조성물을 제조하는 단계는,
상기 화장료 조성물에 클로르페네신(chlorphenesin) 및 트로폴론(tropolone) 중에서 선택되는 어느 하나 이상의 화합물을 조성물 총 중량에 대하여 1 내지 40 중량% 첨가하는 것을 특징으로 하는 화장료 조성물 제조 방법.
The method of claim 10,
The step of preparing the cosmetic composition,
Method for producing a cosmetic composition, characterized in that 1 to 40% by weight based on the total weight of the composition of any one or more compounds selected from chlorphenesin (chlorphenesin) and tropolone (tropolone) to the cosmetic composition.
삭제delete
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US20030022941A1 (en) * 2001-03-27 2003-01-30 Taylor Timothy J. Antibacterial compositions

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