KR101871347B1 - Novel pathogenic Escherichia coli specific bacteriophage EC121 and antibacterial composition comprising the same - Google Patents

Novel pathogenic Escherichia coli specific bacteriophage EC121 and antibacterial composition comprising the same Download PDF

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KR101871347B1
KR101871347B1 KR1020160178107A KR20160178107A KR101871347B1 KR 101871347 B1 KR101871347 B1 KR 101871347B1 KR 1020160178107 A KR1020160178107 A KR 1020160178107A KR 20160178107 A KR20160178107 A KR 20160178107A KR 101871347 B1 KR101871347 B1 KR 101871347B1
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bacteriophage
escherichia coli
present
pathogenic escherichia
coli
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연영은
김영주
한범구
김현일
박철세
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주식회사 옵티팜
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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    • C12N2795/00—Bacteriophages
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Abstract

The present invention relates to a novel bacteriophage EC121 having a killing functions specific to pathogenic Escherichia coli; a pharmaceutical composition, an antibiotic composition, a fodder adding composition, a fodder, a disinfection agent, or a washing agent for preventing or treating infectious diseases caused by pathogenic Escherichia coli, which include the bacteriophage; and a method for preventing or treating infectious diseases caused by pathogenic Escherichia coli. The method for preventing or treating infectious diseases caused by pathogenic Escherichia coli of the present invention has an excellent bacteriolysis activity, and is strong to physiochemical stimulation.

Description

신규한 병원성 대장균 특이 박테리오파지 EC121 및 이를 포함하는 항균 조성물{Novel pathogenic Escherichia coli specific bacteriophage EC121 and antibacterial composition comprising the same}A novel pathogenic Escherichia coli-specific bacteriophage EC121 and an antimicrobial composition comprising the Escherichia coli specific bacteriophage EC121 and antibacterial composition [

본 발명은 병원성 대장균, 특히 시가독소 생성 대장균(Shigatoxin producing E. coli, STEC) 및 항생제 내성 대장균인 ESBL(Extended Spectrum β-lactamase) 생성 대장균에 특이적인 사멸능을 갖는 신규 박테리오파지 EC121, 상기 박테리오파지를 포함하는 병원성 대장균에 의한 감염성 질병의 예방 또는 치료용 약학적 조성물, 항생용 조성물, 사료 첨가용 조성물, 사료, 소독제 또는 세척제 및 상기 박테리오파지를 개체에 투여하는 단계를 포함하는 병원성 대장균에 의한 감염성 질병의 예방 또는 치료 방법에 관한 것이다. The present invention relates to a novel bacteriophage EC121 having the ability to kill pathogenic Escherichia coli, particularly Shigatoxin producing E. coli (STEC) and Escherichia coli producing ESBL (Extended Spectrum β-lactamase) which is an antibiotic resistant Escherichia coli, and bacteriophage Prevention of infectious diseases caused by pathogenic Escherichia coli including pharmaceutical compositions, antibiotic compositions, compositions for feed additives, feeds, disinfectants or cleaning agents for the prevention or treatment of infectious diseases caused by pathogenic Escherichia coli, and the step of administering the bacteriophages to the individuals Or a method of treatment.

일반적으로 대장균(Escherichia coli , E. coli)은 장내세균과 (Enterobacteriaceae)의 Escherichia 속에 속하는 그람음성의 단간균으로 포유동물을 비롯한 다양한 동물의 장관 내에 존재하는 정상세균 총 중의 하나이다. 대장균은 일반적으로 대장에 정상적으로 존재하는 비병원성 대장균과 특정 병원성 인자(부착인자 및 내열성 독소 등)를 획득하여 병증을 유발하는 병원성 대장균으로 구분할 수 있다. 대장균은 온혈 동물의 장내에 많은 부분을 차지하고 있는 미생물이나 대부분 비병원성 세균으로 기회감염을 유발할 수 있다. 비병원성 대장균 외의 대장균은 사람에 있어서는 설사증, 요로감염증, 패혈증 및 뇌막염 등의 질환을 유발할 수 있는 병원성 미생물이다. 최근에는 다양한 병원성 대장균이 진단, 검출되고 있는데, 장독소성 대장균 (Enterotoxigenic E. coli, ETEC), 장병원성 대장균 (Enteropathogenic E. coli, EPEC), 장출혈성 대장균 (Enterohemorrhagic E. coli, EHEC), 그리고 장응집성 대장균 (Enteroaggregative E. coli , EAEC) 등으로 분류될 수 있다. Generally, Escherichia coli and E. coli are gram-negative staphylococci belonging to the genus Escherichia of Enterobacteriaceae and are one of the normal bacterial germs present in the intestines of various animals including mammals. Escherichia coli is generally classified into non-pathogenic Escherichia coli normally present in the large intestine and pathogenic Escherichia coli producing pathogenic factors such as adherence factors and heat-resistant toxins. Escherichia coli may cause opportunistic infections due to microorganisms or mostly non-pathogenic bacteria that occupy a large part of the intestine of warm-blooded animals. Escherichia coli other than non-pathogenic Escherichia coli is a pathogenic microorganism which can cause diseases such as diarrhea, urinary tract infections, sepsis and meningitis in humans. Recently, there is a wide range of pathogenic E. coli and detection diagnosis, E. coli enterotoxins firing (Enterotoxigenic E. coli, ETEC), Chapter E. coli (Enteropathogenic E. coli, EPEC), Chapter hemorrhagic Escherichia coli (Enterohemorrhagic E. coli, EHEC), and Chapter Enteroaggregative E. coli ( EAEC), and the like.

또한, 대장균은 다양한 환경에서 많은 분포로 존재하는 만큼 세균을 제어하기 위해 사용되는 항생제, 약제, 항미생물제 등에 노출되어 있다. 이에 따라 다양한 항생제에 내성을 나타내는 내성세균이 출현하고 있다. 특히 항생제 중 베타-락탐(ß-lactam) 제제는 감염증 치료에 흔히 사용되는 항생제로, 병원에서 치료제로서 3세대 세팔로스포린 항균제들을 집중적으로 사용하게 되면서 이에 대한 내성균주들이 출현하게 되었고, 다양한 베타-락탐 계열의 항생제에 내성을 나타내는 세균을 ESBL(Extended Spectrum ß-lactamase) 생성 세균이라고 하는데, 현재 임상에서 빈번하게 분리되고 있다. ESBL 생성 균주는 주로 장내세균과(Enterobacteriaceae)의 세균에서 생성되며 세포탁심(cefotaxime), 세프타지딤(ceftazidime), 아즈트레오남(aztreonam)과 같은 소위 제 3세대 항균제들에 대해서 내성을 가지고 있다.In addition, Escherichia coli is exposed to antibiotics, drugs, antimicrobial agents, and the like, which are used to control bacteria as much as they exist in various environments. As a result, resistant bacteria showing resistance to various antibiotics are emerging. In particular, beta-lactam (antibiotics) is an antibiotic commonly used for the treatment of infectious diseases. As the third-generation cephalosporin antibiotics are used as a therapeutic agent in hospitals, Bacterium that is resistant to lactam antibiotics is called ESBL (Extended Spectrum β-lactamase) -generating bacterium. ESBL-producing strains are mainly produced by Enterobacteriaceae bacteria and are resistant to so-called third-generation antibiotics such as cefotaxime, ceftazidime, and aztreonam.

한편, 박테리오파지(bacteriophage)는 특정 세균을 감염시켜 감염된 세균의 성장을 억제하고 저해하는 세균 특이적 바이러스를 의미한다. 박테리오파지는 박테리아에 감염(infection)한 후 박테리아 세포 내부에서 증식을 하고, 증식 후 자손 박테리오파지들이 박테리아 밖으로 나올 때 숙주인 박테리아의 세포벽을 파괴하는 방식으로 박테리아를 사멸시키는 능력을 갖고 있다. 박테리오파지의 박테리아 감염 방식은 매우 특이성이 높아서 특정 박테리아에 감염할 수 있는 박테리오파지의 종류는 일부로 한정된다. 즉, 특정 박테리오파지는 특정 범주의 박테리아에만 감염할 수 있고 이로 인하여 특정 박테리오파지는 특정 박테리아만을 사멸시키며 다른 박테리아에는 영향을 주지 않는다. 따라서 최근 세균성 질환의 대처 방안으로 박테리오파지(bacteriophage)의 활용이 크게 주목을 받고 있다. 특히 2000년 이후에 항생제 내성균의 증가로 인하여 기존 항생제의 한계성이 나타나고, 기존 항생제의 대체 물질로의 개발 가능성이 부각되면서 다시 박테리오파지가 항-박테리아제로 주목을 받고 있다.On the other hand, bacteriophage refers to a bacterium-specific virus that infects a specific bacterium to inhibit and inhibit the growth of the infected bacterium. Bacteriophages have the ability to kill bacteria by infecting bacteria, multiplying inside bacterial cells, and destroying the cell walls of the host bacteria when the progeny bacteriophages come out of the bacteria after proliferation. The bacteriophage infection method of bacteriophage is highly specific, so the type of bacteriophage that can infect a specific bacterium is limited to some. That is, certain bacteriophages can infect only a specific category of bacteria, which causes certain bacteriophages to kill only certain bacteria and not other bacteria. Recently, the use of bacteriophage has attracted much attention as a countermeasure against bacterial diseases. Especially, since 2000, the limit of existing antibiotics has appeared due to the increase of antibiotic resistant bacteria, and bacteriophage is attracting attention as an anti - bacterial agent again with the possibility of development as a substitute for existing antibiotics.

그러나 현재까지 병원성 대장균에 의한 감염증을 예방 또는 치료하기 위한 신규한 박테리오파지에 대한 연구는 여전히 부족한 실정이다. 따라서 대장균 중에서도 병원성 대장균에 특이적인 용균활성을 갖는 박테리오파지 및 이의 응용에 대한 기술 개발이 필요하다.However, to date, there is still a lack of research on novel bacteriophages for the prevention or treatment of infectious diseases caused by pathogenic Escherichia coli. Therefore, it is necessary to develop technology for bacteriophage having bactericidal activity specific to pathogenic Escherichia coli and its application among E. coli.

이에 본 발명자들은 병원성 대장균에 특이적인 용균활성을 갖는 박테리오파지를 분리하고 분리된 박테리오파지의 형태적 및 유전적 특성을 분석하여 상기 박테리오파지가 병원성 대장균인 시가독소 생성 대장균(Shigatoxin producing E. coli, STEC) 및 항생제 내성 대장균인 ESBL(Extended Spectrum β-lactamase) 생성 대장균을 선택적으로 사멸시킬 수 있음을 확인함으로써 본 발명을 완성하였다.Accordingly, the present inventors isolated bacteriophage having a lytic activity specific to pathogenic Escherichia coli and analyzed the morphological and genetic characteristics of the bacteriophage thus isolated, and found that the bacteriophage is a pathogenic Escherichia coli (Shigatoxin producing E. coli , STEC) and And ESBL (Extended Spectrum? -Lactamase) -generating Escherichia coli, which is an antibiotic-resistant Escherichia coli, can be selectively killed.

본 발명의 목적은 병원성 대장균에 특이적인 사멸능을 갖는, 서열번호 1로 표시되는 염기서열로 이루어진 박테리오파지 EC121을 제공하는 것이다.It is an object of the present invention to provide a bacteriophage EC121 comprising the nucleotide sequence shown in SEQ ID NO: 1, which has a killing activity specific to pathogenic Escherichia coli.

본 발명의 또 다른 목적은 상기 박테리오파지 EC121을 포함하는, 병원성 대장균에 의한 감염성 질병의 예방 또는 치료용 약학적 조성물을 제공하는 것이다.It is still another object of the present invention to provide a pharmaceutical composition for preventing or treating infectious diseases caused by pathogenic Escherichia coli, which comprises the bacteriophage EC121.

본 발명의 또 다른 목적은 상기 박테리오파지 EC121을 포함하는, 항생용 조성물, 사료 첨가용 조성물, 사료, 소독제 또는 세척제를 제공하는 것이다.It is still another object of the present invention to provide an antibiotic composition, composition for feed addition, feed, disinfectant, or detergent comprising the bacteriophage EC121.

본 발명의 또 다른 목적은 상기 박테리오파지 EC121을 개체에 투여하는 단계를 포함하는, 병원성 대장균에 의한 감염성 질병의 예방 또는 치료 방법을 제공하는 것이다.Yet another object of the present invention is to provide a method for preventing or treating an infectious disease caused by pathogenic Escherichia coli, which comprises the step of administering the bacteriophage EC121 to an individual.

상기 목적을 달성하기 위하여, 본 발명은 병원성 대장균(Escherichia coli)에 특이적인 사멸능을 갖는, 서열번호 1로 표시되는 염기서열로 이루어진 박테리오파지 EC121을 제공한다.In order to achieve the above object, the present invention provides a method for producing Escherichia coli The bacteriophage EC121 comprising the nucleotide sequence of SEQ ID NO: 1, which has the killing activity specific to E. coli, is provided.

또한, 본 발명은 상기 박테리오파지 EC121을 포함하는, 병원성 대장균에 의한 감염성 질병의 예방 또는 치료용 약학적 조성물을 제공한다.In addition, the present invention provides a pharmaceutical composition for preventing or treating infectious diseases caused by pathogenic Escherichia coli, which comprises the bacteriophage EC121.

또한, 본 발명은 상기 박테리오파지 EC121을 포함하는, 항생용 조성물을 제공한다.In addition, the present invention provides an antibiotic composition comprising the bacteriophage EC121.

또한, 본 발명은 상기 박테리오파지 EC121을 포함하는, 사료 첨가용 조성물을 제공한다.In addition, the present invention provides a composition for feed addition comprising the bacteriophage EC121.

또한, 본 발명은 상기 박테리오파지 EC121을 포함하는, 소독제를 제공한다.The present invention also provides a disinfectant comprising the bacteriophage EC121.

또한, 본 발명은 상기 박테리오파지 EC121을 포함하는, 세척제를 제공한다.The present invention also provides a cleaning agent comprising the bacteriophage EC121.

또한, 본 발명은 상기 박테리오파지 EC121을 개체에 투여하는 단계를 포함하는, 병원성 대장균에 의한 감염성 질병의 예방 또는 치료 방법을 제공한다.In addition, the present invention provides a method for preventing or treating infectious diseases caused by pathogenic Escherichia coli, comprising the step of administering the bacteriophage EC121 to an individual.

본 발명의 박테리오파지 EC121을 이용한 병원성 대장균에 의한 감염성 질병의 예방 또는 치료 방법은 기존의 항생제 등의 화학물질에 비해 병원성 대장균, 특히 시가독소 생성 대장균 및 항생제 내성 대장균에 대한 특이성이 매우 높고, 상기 박테리오파지 EC121은 상기 대장균에 감염하여 대장균 내에서 증식함으로써 용균 활성이 우수하고 물리화학적 자극에 강하다는 장점을 가지고 있다. 또한 본 발명의 박테리오파지 EC121은 사람, 동물, 식물 등 세균외의 다른 숙주에는 감염되지 않으므로, 항생제의 오남용으로 인한 항생제 내성균의 문제점, 식품 내의 항생제의 잔류 문제, 광범위한 숙주범위의 문제점을 해결할 수 있는 장점이 있다. 따라서, 본 발명의 박테리오파지 EC121은 병원성 대장균에 의한 감염성 질병의 예방 또는 치료, 항생용 조성물, 사료 첨가용 조성물, 사료, 소독제, 또는 세척제 분야에서 다양하게 사용될 수 있다.The method for the prevention or treatment of infectious diseases caused by pathogenic Escherichia coli using the bacteriophage EC121 of the present invention is highly specific to pathogenic Escherichia coli, especially Escherichia coli producing Escherichia coli and antibiotic-resistant Escherichia coli compared to existing antibiotics and other chemicals, Has an advantage of being excellent in lytic activity and strong against physicochemical stimulation by being infected with E. coli and proliferating in E. coli. In addition, the bacteriophage EC121 of the present invention is not infected by any host other than a bacterium such as human, animal, or plant. Therefore, the bacteriophage EC121 of the present invention can solve problems of antibiotic resistant bacteria caused by abuse of antibiotics, residual antibiotics in food, have. Accordingly, the bacteriophage EC121 of the present invention can be used in various fields in the field of prevention or treatment of infectious diseases caused by pathogenic Escherichia coli, compositions for antibiosis, composition for feed addition, feed, disinfectant, or detergent.

도 1은 항생제 내성을 가지는 대장균에 대해 특이적인 박테리오파지의 스크리닝 결과를 나타낸 도이다.
도 2는 박테리오파지 EC121의 대장균에 대한 용균반 형성 활성을 확인한 결과를 나타낸 도이다.
도 3은 박테리오파지 EC121의 전체 유전자를 분석한 결과를 나타낸 도이다.
도 4는 전자 현미경을 통해 박테리오파지 EC121의 형태학적 특성을 확인한 결과를 나타낸 도이다.
도 5는 박테리오파지 EC121의 단백질 패턴을 SDS-PAGE를 통해 확인한 결과를 나타낸 도이다.
도 6은 박테리오파지 EC121의 pH 안정성을 확인한 결과를 나타낸 도이다.
도 7은 박테리오파지 EC121의 열 안정성을 확인한 결과를 나타낸 도이다.Fig. 1 is a diagram showing screening results of bacteriophage specific for E. coli having antibiotic resistance.
Fig. 2 is a graph showing the result of confirming the activity of the bacteriophage EC121 to form a fungus-forming activity against E. coli.
3 is a diagram showing the result of analysis of the entire gene of bacteriophage EC121.
FIG. 4 is a graph showing the morphological characteristics of bacteriophage EC121 observed through an electron microscope.
FIG. 5 is a graph showing the result of SDS-PAGE of the protein pattern of bacteriophage EC121.
6 is a graph showing the result of confirming the pH stability of bacteriophage EC121.
7 is a graph showing the results of confirming the thermal stability of bacteriophage EC121.

이하, 본 발명에 대해 상세히 설명한다.Hereinafter, the present invention will be described in detail.

본 발명은 병원성 대장균에 특이적인 사멸능을 갖는, 서열번호 1로 표시되는 염기서열로 이루어진 박테리오파지 EC121을 제공한다.The present invention provides a bacteriophage EC121 comprising the nucleotide sequence shown in SEQ ID NO: 1, which has a killing activity specific to pathogenic Escherichia coli.

본 발명에서, 용어 “박테리오파지(bacteriophage)”는 특정 세균에 감염하여 당해 세균의 성장을 억제하고 저해하는 세균 특이적 바이러스로, 단일 혹은 이중 사슬의 DNA 또는 RNA를 유전 물질로 포함하는 바이러스를 의미한다.In the present invention, the term " bacteriophage " means a bacterium-specific virus that infects a specific bacterium and inhibits and inhibits the growth of the bacterium, and includes a single or double-stranded DNA or RNA as a genetic material .

본 발명에서, 상기 병원성 대장균은 시가독소 생성 대장균(Shigatoxin producing E. coli, STEC), 장독소성 대장균 (Enterotoxigenic E. coli, ETEC), 장병원성 대장균 (Enteropathogenic E. coli, EPEC), 장출혈성 대장균 (Enterohemorrhagic E. coli, EHEC), 또는 장응집성 대장균 (Enteroaggregative E. coli , EAEC)을 포함하며, 바람직하게는 시가독소 생성 대장균(Shigatoxin producing E. coli, STEC)이나 이에 제한되지 않는다. In the present invention, the pathogenic Escherichia coli is selected from the group consisting of Shigatoxin producing E. coli (STEC), Enterotoxigenic E. coli (ETEC), Enteropathogenic E. coli (EPEC), Enterohemorrhagic Escherichia coli Enterohemorrhagic E. coli , EHEC), or Enteroaggregative E. coli ( EAEC), preferably, but not limited to, Shigatoxin producing E. coli (STEC).

본 발명에서, 상기 병원성 대장균은 항생제 내성 대장균을 포함한다. In the present invention, the pathogenic Escherichia coli includes an antibiotic-resistant Escherichia coli.

상기 항생제 내성 대장균은 ESBL(Extended Spectrum β-lactamase) 생성 대장균(Escherichia coli)을 포함하나 이에 제한되지 않는다. The antibiotic-resistant E. coli includes, but is not limited to, ESBL (Extended Spectrum β-lactamase) -generating Escherichia coli .

상기 ESBL 생성 대장균은 광범위 베타락탐 분해 효소(Extended Spectrum β-lactamase, ESBL)를 생성하는 대장균을 지칭한다. ESBL은 3세대 세팔로스포린(cephalosporin)을 가수분해하는 베타 락타마아제를 포함하는 넓은 개념이다. The ESBL-producing Escherichia coli refers to Escherichia coli producing a broad spectrum beta-lactamase (ESBL). ESBL is a broad concept that includes beta-lactamases that hydrolyze third generation cephalosporins.

본 발명의 ESBL 생성 대장균은 ESBL을 생성함으로써 베타락탐계 항생제에 내성을 갖는 것을 특징으로 한다. 베타락탐계 항생제(β-lactam antibiotics)는 페니실린, 세팔로스포린, 모노박탐, 카바페넴, 베타-락탐 분해효소 저해제를 총칭하는 단어로, 모두 베타락탐 핵을 분자 구조 내에 포함하고 있다. 베타락탐계 항생제는 예컨대 메티실린(메탐피실린), 디클록사신, 옥사실린, 플루클록사신, 아목시실린, 암피실린, 피페라실린, 티카실린, 아즐로실린, 카르베니실린과 같은 페니실린계, 세팔렉신, 세팔로틴, 세파졸린, 세프테졸, 세파제돈, 세파클러, 세푸록심, 세파맨돌, 세포테탄, 세폭시틴, 세프트리악손, 세프탁심, 세프타지딤, 세파핌, 세프피롬과 같은 세팔로스포린계, 이미페넴, 메로페넴, 에르타페넴, 파로페넴과 같은 카바페넴계, 아즈트레오남과 같은 모노박탐계 항생제를 포함하나 이에 제한되는 것은 아니다. The ESBL producing Escherichia coli of the present invention is characterized by being resistant to a beta lactam antibiotic by producing ESBL. Beta-lactam antibiotics are generic terms of penicillin, cephalosporin, monobactam, carbapenem, and beta-lactamase inhibitors, all of which contain beta-lactam nuclei in the molecular structure. Beta-lactam antibiotics include, for example, penicillins such as methicillin (methamphetamine), dicloxacin, oxacillin, flucloxacin, amoxicillin, ampicillin, piperacillin, ticacillin, azulocillin, carbenicillin, , Cephalosporins such as cephalotin, cephazoline, ceftizole, cephadone, separac, cefuroxime, cephamandol, cytetan, cepoxitin, ceftriaxone, ceftazim, ceftazidime, But are not limited to, carbapenems such as spearin, imipenem, meropenem, erthapenem, and paropenem, and monovavirus antibiotics such as aztreonam.

본 발명의 박테리오파지 EC121은 약 200 nm의 크기로, 정이십면체의 머리를 가지며 수축성 꼬리가 있는 마이오비리데(Myoviridae)에 속한다. 상기 박테리오파지 EC121의 단백질 패턴 분석 결과 120 kDa, 70 kDa, 50 kDa 크기의 주요 단백질을 포함하고, 전체 염기서열 분석 결과 168,805 bp의 크기를 갖고, GC 함량이 35.5%, 전체 ORFs의 수는 277개임을 확인하였다. 그 전체 염기서열을 서열번호 1로 표시하였다. 또한 상기 박테리오파지 EC121은 열 및 pH에 대한 안정성이 우수한 특성을 가지고 있다.The bacteriophage EC121 of the present invention belongs to Myoviridae, which is about 200 nm in size and has a twisted-sided head and has a contractile tail. Protein pattern analysis of the bacteriophage EC121 revealed that it contained major proteins of 120 kDa, 70 kDa, and 50 kDa in size. As a result of the whole sequence analysis, it has a size of 168,805 bp, a GC content of 35.5% and a total ORF of 277 Respectively. The entire nucleotide sequence thereof is shown in SEQ ID NO: 1. The bacteriophage EC121 has excellent stability against heat and pH.

본 발명의 박테리오파지 EC121은 서열번호 1로 표시되는 염기서열을 전체 유전자의 전체 또는 일부로서 포함할 수 있다. 또한, 본 발명의 박테리오파지 EC121은 서열번호 1로 표시되는 염기서열, 및 상기 염기서열의 기능적 동등물로 이루어질 수 있다. 상기 기능적 동등물이란 염기서열의 변형, 치환의 결과, 상기 서열번호 1로 표시되는 염기서열과 적어도 70% 이상, 바람직하게는 80% 이상, 더욱 바람직하게는 90% 이상, 더더욱 바람직하게는 95% 이상의 서열 상동성을 갖는 것으로, 서열번호 1로 표시되는 염기서열과 실질적으로 동질의 생리활성을 나타내는 서열을 의미한다.The bacteriophage EC121 of the present invention may include the nucleotide sequence shown in SEQ ID NO: 1 as whole or a part of the entire gene. In addition, the bacteriophage EC121 of the present invention may be composed of the nucleotide sequence shown in SEQ ID NO: 1 and the functional equivalent of the nucleotide sequence. The functional equivalent means at least 70% or more, preferably 80% or more, more preferably 90% or more, still more preferably 95% or more of the nucleotide sequence shown in SEQ ID NO: 1 as a result of modification or substitution of the nucleotide sequence. Or more and having substantially the same physiological activity as the nucleotide sequence shown in SEQ ID NO: 1.

상기와 같은 병원성 대장균 특이적 용균활성, 내산성, 내열성은 본 발명의 박테리오파지 EC121을 병원성 대장균에 의한 감염성 질병의 예방 및 치료용 조성물, 및 상기 박테리오파지 EC121을 유효성분으로 포함하는 다양한 제품에 적용함에 있어, 다양한 온도 및 pH 범위의 적용이 가능하게 한다.The above-mentioned pathogenic Escherichia coli-specific lytic activity, acid resistance, and heat resistance are determined by applying the bacteriophage EC121 of the present invention to a composition for the prevention and treatment of infectious diseases caused by pathogenic Escherichia coli and various products containing the bacteriophage EC121 as an active ingredient, Making it possible to apply various temperature and pH ranges.

본 발명의 박테리오파지 EC121은 양돈농장 및 양계농장 부근의 하수와 병원 근처의 하천으로부터 시료를 채취하여 분리한 박테리오파지로서, 본 발명자는 이를 박테리오파지 EC121로 명명하고 2016년 9월 30일에 한국미생물보존센터에 수탁번호 KFCC11691P로 기탁하였다. The bacteriophage EC121 of the present invention is a bacteriophage obtained by collecting a sample from a sewage near a pig farm and a poultry farm and a stream near a hospital and named it as bacteriophage EC121 and on September 30, Deposit number KFCC11691P.

또한, 본 발명은 상기 박테리오파지 EC121을 포함하는, 병원성 대장균에 의한 감염성 질병의 예방 또는 치료용 약학적 조성물을 제공한다.In addition, the present invention provides a pharmaceutical composition for preventing or treating infectious diseases caused by pathogenic Escherichia coli, which comprises the bacteriophage EC121.

본 발명의 박테리오파지 EC121은 병원성 대장균에 특이적인 사멸능을 가지므로, 병원성 대장균에 의한 감염성 질병의 예방 또는 치료용 약학적 조성물에 사용될 수 있다. 보다 구체적으로, 본 발명의 박테리오파지 EC121은 시가독소 생성 대장균 또는 ESBL 생성 대장균에 대한 특이적인 사멸능을 가지므로, 상기 대장균에 의한 감염성 질병의 예방 또는 치료용 약학적 조성물에 사용될 수 있으나, 이에 제한되는 것은 아니다.Since the bacteriophage EC121 of the present invention has a killing activity specific to pathogenic Escherichia coli, it can be used in a pharmaceutical composition for the prevention or treatment of infectious diseases caused by pathogenic Escherichia coli. More specifically, the bacteriophage EC121 of the present invention has a specific killing activity against cytotoxin-producing Escherichia coli or ESBL-producing Escherichia coli, and thus can be used in a pharmaceutical composition for the prevention or treatment of infectious diseases caused by Escherichia coli. It is not.

본 발명에서, 병원성 대장균에 의한 감염성 질병은 대장균증을 의미하는 것으로 그 증상으로 식중독, 설사, 패혈증, 뇌막염, 방광염 및 부종병 등을 포함하나, 이에 제한되는 것은 아니며, 병원성 대장균에 의한 2차 감염을 포함한다. In the present invention, an infectious disease caused by a pathogenic Escherichia coli refers to Escherichia coli, which includes, but is not limited to, food poisoning, diarrhea, sepsis, meningitis, cystitis and edema, and the second infection by pathogenic Escherichia coli .

본 발명의 약학적 조성물은 1 × 103 내지 1 × 1010 PFU/mL의 박테리오파지를 포함하며, 바람직하게는 1 × 106 내지 1 × 109 PFU/mL의 박테리오파지를 포함한다. 본 발명에 사용된 용어, “PFU (plaque forming unit)”는 박테리오파지가 플라크를 형성하는 것을 수치화한 단위이다.The pharmaceutical composition of the present invention contains bacteriophage of 1 × 10 3 to 1 × 10 10 PFU / mL, preferably 1 × 10 6 to 1 × 10 9 PFU / mL of bacteriophage. As used herein, the term " PFU (plaque forming unit) " is a unit that quantifies the formation of a plaque by a bacteriophage.

본 발명의 용어 “예방”이란 조성물의 투여로 질병을 억제시키거나 발병을 지연시키는 모든 행위를 의미한다.The term " prophylactic " of the present invention means any action that inhibits the disease or delay the onset of the disease by administration of the composition.

본 발명의 용어 “치료”란 조성물의 투여로 상기 질병의 증세가 호전되거나 상기 질병의 억제 또는 경감 및 이롭게 변경되는 모든 행위를 의미한다.The term " treatment " of the present invention means all the acts of improving the symptom of the disease or inhibiting or alleviating and beneficially altering the disease upon administration of the composition.

본 발명의 약학적 조성물은 약학적으로 허용 가능한 담체를 추가로 포함할 수 있다.The pharmaceutical composition of the present invention may further comprise a pharmaceutically acceptable carrier.

본 발명에서 용어, “약학적으로 허용 가능한 담체”란 생물체를 자극하지 않고 투여 화합물의 생물학적 활성 및 특성을 저해하지 않는 담체 또는 희석제를 의미한다. 액상 용액으로 제제화되는 조성물에 있어서 허용되는 약제학적 담체로는, 멸균 및 생체에 적합한 것으로서, 식염수, 멸균수, 링거액, 완충 식염수, 알부민 주사용액, 덱스트로오스 용액, 말토 덱스트린 용액, 글리세롤, 에탄올 및 이들 성분 중 1 성분 이상을 혼합하여 사용할 수 있으며, 필요에 따라 항산화제, 완충액, 정균제 등 다른 통상의 첨가제를 첨가할 수 있다. 또한 희석제, 분산제, 계면활성제, 결합제 및 윤활제를 부가적으로 첨가하여 수용액, 현탁액, 유탁액 등과 같은 주사용 제형, 환약, 캡슐, 과립 또는 정제로 제제화할 수 있다.As used herein, the term " pharmaceutically acceptable carrier " means a carrier or diluent that does not irritate the organism and does not interfere with the biological activity and properties of the administered compound. Examples of the pharmaceutical carrier which is acceptable for the composition to be formulated into a liquid solution include sterilized and sterile water, sterile water, Ringer's solution, buffered saline, albumin injection solution, dextrose solution, maltodextrin solution, glycerol, One or more of these components may be mixed and used. If necessary, other conventional additives such as an antioxidant, a buffer, and a bacteriostatic agent may be added. In addition, diluents, dispersants, surfactants, binders, and lubricants may be additionally added to formulate into injectable solutions, pills, capsules, granules or tablets such as aqueous solutions, suspensions, emulsions and the like.

본 발명의 약학적 조성물은 질환 부위에의 도포 또는 분무하는 방법으로 이용할 수 있으며, 그 밖에 비강 분무, 경구 투여 또는 비경구 투여를 통해 투여할 수도 있으며, 비경구 투여의 경우 정맥 내 투여, 복강 내 투여, 근육 내 투여, 피하 투여 또는 국부 투여를 이용하여 투여할 수도 있다.The pharmaceutical composition of the present invention can be used as a method of applying or spraying on a diseased site, or may be administered through nasal spray, oral administration or parenteral administration. In the case of parenteral administration, intravenous administration, intraperitoneal administration Administration, intramuscular, subcutaneous or local administration.

상기 비강 분무의 경우 일정량의 박테리오파지 EC121을 물에 희석하여 분무기나 분무 시스템을 통해 비강으로 흡수 되도록 할 수 있다. 상기 비강 분무를 위한 비강 분무제 또는 호흡기용 제형으로는 에어로졸제 등을 들 수 있다.In the case of the nasal spray, a certain amount of bacteriophage EC121 can be diluted in water and absorbed into the nasal cavity through a sprayer or spray system. Examples of the nasal spray agent for the nasal spray or the aerosol agent for the respiratory system are mentioned.

상기 비강 분무제 또는 호흡기용 제형은, 수분산된 농축물 또는 습윤 분말을 분산시키기 위한 추진제 및/또는 기타 첨가제를 추가로 포함할 수 있다.The nasal spray or respiratory formulation may further comprise a propellant and / or other additives for dispersing the water-dispersed concentrate or wet powder.

본 발명의 약학적 조성물의 적합한 도포, 분무 및 투여량은 제제화 방법, 투여 방식, 대상이 되는 동물 및 환자의 연령, 체중, 성, 질병 증상의 정도, 음식, 투여시간, 투여 경로, 배설 속도 및 반응 감응성과 같은 요인들에 의해 다양하며, 보통으로 숙련된 의사나 수의사는 목적하는 치료에 효과적인 투여량을 용이하게 결정 및 처방할 수 있다.The appropriate application, spray and dose of the pharmaceutical composition of the present invention may vary depending on factors such as formulation method, administration method, age, body weight, sex, disease symptom level, food, administration time, administration route, Response sensitivities, and the ordinarily skilled physician or veterinarian can readily determine and prescribe dosages effective for the desired treatment.

본 발명의 약학적 조성물을 유효성분으로 포함하는 경구 투여용 제형으로는, 예를 들어 정제, 트로키제, 로렌지, 수용성 또는 유성현탁액, 조제분말 또는 과립, 에멀젼, 하드 또는 소프트 캡슐, 시럽 또는 엘릭시르제로 제제화할 수 있다. 정제 및 캡슐 등의 제형으로 제제화하기 위해, 락토오스, 사카로오스, 솔비톨, 만니톨, 전분, 아밀로펙틴, 셀룰로오스 또는 젤라틴과 같은 결합제, 디칼슘 포스페이트와 같은 부형제, 옥수수 전분 또는 고구마 전분과 같은 붕괴제, 스테아르산 마스네슘, 스테아르산 칼슘, 스테아릴푸마르산 나트륨 또는 폴리에틸렌글리콜 왁스와 같은 윤활유를 포함할 수 있으며, 캡슐 제형의 경우 상기 언급한 물질 외에도 지방유와 같은 액체 담체를 더 함유할 수 있다.Examples of formulations for oral administration comprising the pharmaceutical composition of the present invention as an active ingredient include tablets, troches, lozenges, aqueous or oily suspensions, prepared powders or granules, emulsions, hard or soft capsules, syrups or elixirs It can be formulated into a zero. A binder such as lactose, saccharose, sorbitol, mannitol, starch, amylopectin, cellulose or gelatin, an excipient such as dicalcium phosphate, a disintegrating agent such as corn starch or sweet potato starch, Calcium stearate, calcium stearate, sodium stearyl fumarate or polyethylene glycol wax. In the case of a capsule formulation, in addition to the above-mentioned materials, a liquid carrier such as a fatty oil may be further contained.

본 발명의 약학적 조성물을 유효성분으로 포함하는 비경구 투여용 제형으로는, 피하주사, 정맥주사 또는 근육 내 주사 등의 주사용 형태, 좌제 주입방식 또는 호흡기를 통하여 흡입이 가능하도록 하는 에어로졸제 등 스프레이용으로 제제화할 수 있다. 주사용 제형으로 제제화하기 위해서는 본 발명의 조성물을 안정제 또는 완충제와 함께 물에서 혼합하여 용액 또는 현탁액으로 제조하고, 이를 앰플 또는 바이알의 단위 투여용으로 제제화할 수 있다. 에어로졸제 등의 스프레이용으로 제형화하는 경우, 수분산된 농축물 또는 습윤 분말이 분산되도록 추진제 등이 첨가제와 함께 배합될 수 있다.Examples of the formulations for parenteral administration containing the pharmaceutical composition of the present invention as an active ingredient include injection forms such as subcutaneous injection, intravenous injection or intramuscular injection, aerosol formulations such as a suppository injection method or a respiratory apparatus It can be formulated for spraying. For formulation into injectable formulations, the compositions of the present invention may be formulated as solutions or suspensions in water with stabilizers or buffers in water, and formulated for unitary administration of ampoules or vials. When formulated for spraying, such as an aerosol formulation, a propellant or the like may be formulated with the additive such that the water-dispersed concentrate or wet powder is dispersed.

또한, 본 발명은 상기 박테리오파지 EC121을 포함하는, 항생용 조성물을 제공한다. In addition, the present invention provides an antibiotic composition comprising the bacteriophage EC121.

본 발명에서, 용어 “항생용 조성물”은 약제 형태로 개체에 제공되어 균을 사멸시킬 수 있는 제제를 의미하며, 방부제, 살균제, 항생제 및 항균제를 총칭하는 것이다. In the present invention, the term " antibiotic composition " means a preparation which can be given to an individual in the form of a drug to kill the bacterium, and collectively refers to preservatives, bactericides, antibiotics and antibacterial agents.

본 발명의 박테리오파지 EC121은 기존 항생제에 비하여 병원성 대장균에 대한 특이성이 매우 높으므로, 유익균은 죽이지 않고, 특정 병원균만 사멸시킬 수 있고, 약물 내성 내지 저항성을 유도하지 않아, 기존의 항생물질에 비하여 제품수명(life cycling)이 긴 신규 항생제로서 이용될 수 있다.Since the bacteriophage EC121 of the present invention is highly specific to pathogenic Escherichia coli compared to conventional antibiotics, it does not kill beneficial bacteria and can kill only specific pathogens, does not induce drug resistance or resistance, (life cycling) can be used as a new antibiotic.

또한, 본 발명은 상기 박테리오파지 EC121을 포함하는, 사료 첨가용 조성물을 제공한다.In addition, the present invention provides a composition for feed addition comprising the bacteriophage EC121.

축산, 수산업에서 사용되는 사료 첨가용 항생제는 질병의 예방 목적으로 사용되고 있는데, 예방 목적의 항생제 투여는 내성균 발생 가능성을 높이고 가축에 잔류하는 항생제가 사람에게 전달될 수 있어서 문제이다. 항생제가 육류를 통해 인체에 흡수되면 항생제 내성을 유발해 질병의 확산을 부를 수도 있다. 또한, 사료에 섞여 먹이는 항생제의 종류가 많고 이는 다제 내성균 발생 확률이 높아지는 문제점이 있기 때문에 좀 더 자연 친화적이면서도 기존의 항생제의 사용에서 발생한 문제를 해결할 새로운 사료 첨가용 항생물질로서 본 발명의 상기 박테리오파지 EC121을 이용할 수 있다.Antibiotics for feed additive used in animal husbandry and fisheries are used for the prevention of diseases. The administration of antibiotics for prevention is problematic because it increases the possibility of producing resistant bacteria and antibiotics remaining in the livestock can be delivered to humans. If antibiotics are absorbed into the body through meat, they may cause antibiotic resistance and spread the disease. In addition, since there are many kinds of antibiotics mixed with feeds and there is a problem that the probability of occurrence of multidrug-resistant bacteria increases, it is possible to solve the problem caused by the use of existing antibiotics while being more environmentally friendly, as a new feed additive antibiotic substance, Can be used.

또한, 본 발명은 상기 사료 첨가용 조성물을 포함하는 사료를 제공할 수 있으며, 본 발명의 사료는 박테리오파지를 사료 첨가제 형태로 따로 제조하여 사료에 혼합시키거나, 사료 제조 시 직접 첨가시켜 제조할 수 있다. 본 발명의 사료 내 박테리오파지는 액상 또는 건조상태일 수 있으며, 바람직하게는 건조된 분말형태이다. 건조방법은 통풍건조, 자연건조, 분무건조 및 동결건조가 가능하지만, 이에 제한되는 것은 아니다. 본 발명의 박테리오파지는 분말형태로 사료 중량의 0.05 내지 10 중량%, 바람직하게는 0.1 내지 2 중량%의 성분비로 혼합될 수 있다. 또한, 상기 사료는 본 발명의 박테리오파지 외에 사료의 보존성을 높일 수 있는 통상의 첨가제들을 추가로 포함할 수 있다.In addition, the present invention can provide a feed comprising the feed composition, and the feed of the present invention can be prepared by separately preparing bacteriophage as a feed additive and mixing the feed into the feed, . The bacteriophage in the feed of the present invention may be in a liquid or dry state, preferably in the form of a dried powder. Drying methods include, but are not limited to, air drying, natural drying, spray drying and freeze drying. The bacteriophage of the present invention may be mixed in powder form in a composition ratio of 0.05 to 10% by weight, preferably 0.1 to 2% by weight of the feed weight. In addition to the bacteriophages of the present invention, the feed may further include conventional additives that can enhance the preservability of the feed.

본 발명의 사료 첨가용 조성물에는 비병원성의 다른 미생물이 추가로 첨가될 수 있다. 첨가될 수 있는 미생물로는 단백질 분해 효소, 지질 분해효소 및 당 전환 효소를 생산할 수 있는 바실러스 서브틸리스(Bacillus subtilis)와 같은 고초균, 소의 위와 같은 혐기적 조건에서 생리적 활성 및 유기물 분해능이 있는 락토바실러스 균주(Lactobacillus sp.), 가축의 체중을 증가시키며 우유의 산유량을 늘리고 사료의 소화 흡수율을 높이는 효과를 보여주는 아스퍼질러스 오리자에(Aspergillus oryzae)와 같은 사상균 및 사카로미세스 세레비지에 (Saccharomyces cerevisiae)와 같은 효모로 구성된 군으로부터 선택될 수 있다.In the composition for feed addition of the present invention, microorganisms other than non-pathogenic microorganisms may be further added. Examples of microorganisms that can be added include lactobacilli such as Bacillus subtilis capable of producing proteolytic enzymes, lipolytic enzymes and glycosyltransferases, lactobacilli having physiological activity and organic resolution at anaerobic conditions such as bovine, ( Lactobacillus sp.), Filamentous fungi such as Aspergillus oryzae , which increase the body weight of livestock and increase the milk yield and increase digestion rate of feed, and Saccharomyces cerevisiae and yeast such as S. cerevisiae .

본 발명의 박테리오파지 EC121을 포함하는 사료에는 식물성으로는 곡물류, 근과류, 식품가공 부산물류, 조류, 섬유질류, 제약 부산물류, 유지류, 전분류, 박류, 곡물부산물류 등이 있으며, 동물성으로는 단백질류, 무기물류, 유지류, 광물성류, 유지류, 단세포 단백질, 동물성 플랑크톤류, 남은 음식물 등이 있으며 이에 제한되는 것은 아니다.Examples of the feedstuffs containing bacteriophage EC121 of the present invention include cereals, roots, food processing busines, algae, fibers, pharmaceuticals, and oils, fats and oils, But are not limited to, proteins, inorganic materials, fats, oils, fats, oils, monocellular proteins, animal plankton, and remnants.

본 발명의 사료 첨가용 조성물에는 품질 저하를 방지하기 위하여 첨가하는 결착제, 유화제, 보존제 등이 포함될 수 있고, 효용 증대를 위하여 사료에 첨가하는 아미노산제, 비타민제, 효소제, 생균제, 향미제, 비단백태질소화합물, 규산염제, 완충제, 착색제, 추출제, 올리고당 등이 포함될 수 있으며, 그 외에도 사료 혼합제 등을 추가로 포함할 수 있다.The composition for feed addition of the present invention may contain a binder, an emulsifying agent, a preservative, etc. added to prevent deterioration of quality. An amino acid, a vitamin, an enzyme, a probiotic, a flavoring agent, A nitrogen compound, a silicate, a buffer, a coloring agent, an extracting agent, an oligosaccharide, etc., and may further include a feed mixture.

또한, 본 발명은 박테리오파지 EC121을 포함하는, 음용수 첨가제를 제공한다.The present invention also provides a drinking water additive comprising bacteriophage EC121.

본 발명의 음용수 첨가제는 상기 박테리오파지 EC121 또는 이를 포함하는 조성물을 음용수 첨가제 형태로 따로 제조하여 사료 또는 음용수에 혼합하는 방식으로 사용되거나, 음용수 제조 시 직접 첨가하는 방식으로 사용할 수 있다. 상기와 같이 음용수에 혼합하여 공급함으로써 지속적으로 병원성 대장균의 숫자를 감소시킬 수 있는 효과가 있다.The additive for drinking water of the present invention can be used either in the form of separately preparing the bacteriophage EC121 or a composition containing the bacteriophage EC121 as a additive for drinking water, or in a method of mixing it with feed or drinking water, or directly adding it in the production of drinking water. As a result, the number of pathogenic Escherichia coli can be continuously reduced by mixing with drinking water.

본 발명에서 음용수는 특별히 제한되지 아니하며, 당해 기술 분야에서 통상적으로 사용되는 음용수를 사용할 수 있다.In the present invention, the drinking water is not particularly limited, and drinking water commonly used in the art can be used.

또한, 본 발명은 상기 박테리오파지 EC121을 포함하는, 소독제를 제공한다.The present invention also provides a disinfectant comprising the bacteriophage EC121.

병원성 대장균에 특이적 사멸능을 갖는 본 발명의 박테리오파지 EC121을 포함하는 소독제는 병원감염을 막기 위한 병원 및 보건용의 소독제로 유용하게 사용될 수 있고 일반 생활 소독제, 식품 및 조리 장소 및 설비의 소독제, 양계장, 축사 등의 건물, 축체, 음수, 깔짚, 난좌, 운반차량, 식기 등의 각종 생육 용품의 소독 등에 사용될 수 있다.The disinfectant containing the bacteriophage EC121 of the present invention having a specific killing ability against pathogenic Escherichia coli can be effectively used as a disinfectant for hospital and health to prevent hospital infection and can be used as general disinfectant, disinfectant for foods and cooking places and equipment, , Disinfection of various kinds of growing equipments such as buildings such as houses, shaft bodies, negative water, litter, stairs, transportation vehicles, tableware, and the like.

또한, 본 발명은 상기 박테리오파지 EC121을 포함하는, 세척제를 제공한다.The present invention also provides a cleaning agent comprising the bacteriophage EC121.

본 발명의 박테리오파지 EC121은 병원성 대장균에 특이적 사멸능을 가지므로, 병원성 대장균에 노출되었거나 노출될 가능성이 있는 개체의 피부 표면 또는 신체 각 부위 등을 세척하는 용도로도 사용될 수 있다.The bacteriophage EC121 of the present invention has a specific killing ability against pathogenic Escherichia coli, and thus can be used for washing skin surface or body parts of a subject who is exposed or is exposed to pathogenic Escherichia coli.

또한, 본 발명은 상기 박테리오파지 EC121을 개체에 투여하는 단계를 포함하는, 병원성 대장균에 의한 감염성 질병의 예방 또는 치료 방법을 제공한다.In addition, the present invention provides a method for preventing or treating infectious diseases caused by pathogenic Escherichia coli, comprising the step of administering the bacteriophage EC121 to an individual.

본 발명의 박테리오파지 EC121은 병원성 대장균에 특이적인 사멸능을 가지므로, 병원성 대장균에 의한 감염성 질병의 예방 또는 치료에 이용될 수 있다. 보다 구체적으로, 본 발명의 박테리오파지 EC121은 시가독소 생성 대장균 또는 ESBL 생성 대장균에 대한 특이적인 사멸능을 가지므로, 상기 대장균에 의한 감염성 질병의 예방 또는 치료에 이용될 수 있다. Since the bacteriophage EC121 of the present invention has a killing activity specific to pathogenic Escherichia coli, it can be used for the prevention or treatment of infectious diseases caused by pathogenic Escherichia coli. More specifically, the bacteriophage EC121 of the present invention has specific killing activity against cigarette-producing Escherichia coli or ESBL-producing Escherichia coli, and thus can be used for the prevention or treatment of infectious diseases caused by Escherichia coli.

본 발명에서, 병원성 대장균에 의한 감염성 질병은 대장균증을 의미하는 것으로 그 증상으로 식중독, 설사, 패혈증, 뇌막염, 방광염 및 부종병 등을 포함하나, 이에 제한되는 것은 아니며, 병원성 대장균에 의한 2차 감염을 포함한다. In the present invention, an infectious disease caused by a pathogenic Escherichia coli refers to Escherichia coli, which includes, but is not limited to, food poisoning, diarrhea, sepsis, meningitis, cystitis and edema, and the second infection by pathogenic Escherichia coli .

본 발명에서, 용어 "개체"는 병원성 대장균에 의한 감염성 질병이 발병될 수 있는 모든 개체를 의미하는 것으로 인간을 포함한 포유동물, 가축류 또는 가금류를 포함하나, 이에 제한되는 것은 아니다. In the present invention, the term "individual" means any individual to which an infectious disease caused by pathogenic Escherichia coli can be caused, including, but not limited to, mammals including humans, livestock or poultry.

상기 용어 "가축류"는 인간에 의하여 순화, 개량되어 사람과 함께 공동생활을 하는 유용한 동물을 지칭하는 개념으로, 예를 들어, 돼지, 소, 닭, 말, 오리 또는 개 등을 포함하나, 이에 제한되는 것은 아니다.The term " livestock animal "is intended to refer to useful animals that are refined and improved by humans to co-live with humans, including, for example, pigs, cows, chickens, horses, ducks or dogs, It is not.

상기 용어 "가금류"는, 가축 중 조류에 속하는 동물을 총칭하여 이르는 개념으로, 예를 들어, 닭, 오리, 꿩, 메추리, 타조, 거위 또는 칠면조 등을 포함하나, 이에 제한되는 것은 아니다.The term "poultry" includes, but is not limited to, chicken, duck, pheasant, queen, ostrich, goose or turkey.

본 발명의 방법에서 상기 박테리오파지 EC121 또는 조성물은 약학적 제제의 형태로 개체에 투여되거나, 가축의 사료 또는 음용수에 혼합하여 이를 섭식시키는 방법을 통해 투여될 수 있다.In the method of the present invention, the bacteriophage EC121 or the composition may be administered to a subject in the form of a pharmaceutical preparation, or mixed with feed or drinking water of a livestock and fed.

본 발명의 방법에서 상기 박테리오파지 EC121 또는 조성물의 투여 경로는 목적 조직에 도달할 수 있는 한 경구 또는 비경구의 다양한 경로를 통하여 투여될 수 있으며, 구체적으로, 구강, 직장, 국소, 정맥 내, 복강 내, 근육 내, 동맥 내, 경피, 비측 내, 흡입 등을 통해 통상적인 방식으로 투여될 수 있다.In the method of the present invention, the administration route of the bacteriophage EC121 or the composition can be administered through various routes of oral or parenteral administration as long as it can reach the target tissues. Specifically, oral administration, rectal administration, topical administration, intravenous, Intravenous, intramuscular, intraarterial, transdermal, intranasal, inhalation, and the like.

본 발명의 방법에 투여되는 상기 박테리오파지 EC121의 적합한 총 1일 사용량은 올바른 의학적 판단범위 내에서 처치의에 의해 결정될 수 있다는 것은 당업자에게 자명한 일이다. 특정 개체에 대한 구체적인 치료적 유효량은 달성하고자 하는 반응의 종류와 정도, 환자의 연령, 체중, 일반 건강 상태, 성별 및 식이, 투여시간, 투여 경로 및 조성물의 분비율, 치료기간, 구체적 조성물과 함께 사용되거나 동시 사용되는 약물을 비롯한 다양한 인자와 의약 분야에 잘 알려진 유사 인자에 따라 다르게 적용하는 것이 바람직하다.It will be apparent to those skilled in the art that the appropriate total daily dose of the bacteriophage EC121 administered in the methods of the present invention can be determined by treatment within the scope of sound medical judgment. The specific therapeutically effective amount for a particular individual will depend upon the type and extent of the response to be achieved, the age, weight, general health, sex and diet of the patient, the time of administration, the route of administration and the fraction of the route of administration, It is preferable to apply differently depending on various factors including drugs used or co-used and similar factors well known in the medical field.

본 명세서에서 달리 정의되지 않은 용어들은 본 발명이 속하는 기술분야에서 통상적으로 사용되는 의미를 갖는 것이다.Terms not otherwise defined herein have meanings as commonly used in the art to which the present invention belongs.

이하, 본 발명을 실시예, 제제예에 의해 상세히 설명한다. 단, 하기 실시예, 제제예는 본 발명을 예시하는 것일 뿐 본 발명의 내용이 하기 실시예, 제제예에 한정되는 것은 아니다.Hereinafter, the present invention will be described in detail with reference to Examples and Preparation Examples. However, the following examples and preparative examples are merely illustrative of the present invention, and the content of the present invention is not limited to the following examples and preparative examples.

실시예Example 1:  One: 신규한New 박테리오파지의 분리 및 배양 Isolation and culture of bacteriophage

1.1 박테리오파지의 스크리닝 및 분리1.1 Screening and separation of bacteriophages

병원성 대장균에 특이적인 박테리오파지를 스크리닝 및 분리하기 위해서 용균반 분석을 수행하였다. 시료는 박테리오파지가 존재할 것으로 예상되는 양돈농장, 양계농장 부근의 하수와 병원 근처의 하천으로부터 채취하였으며, 박테리오파지 분리에 사용된 병원성 대장균은 (주)옵티팜에서 만성방광염의 증상을 나타내고 있는 개로부터 분리 동정된 후, 항생제 내성을 가지는 것으로 확인된 대장균을 사용하였다.Sputum analysis was performed to screen and isolate bacteriophages specific for pathogenic E. coli. Samples were collected from pig farms, poultry farms near the poultry farms and nearby rivers where bacteriophages are expected to be present, and pathogenic E. coli used for bacteriophage isolation were isolated from dogs showing symptoms of chronic cystitis in Opti Pharm Co., , E. coli which was confirmed to have antibiotic resistance was used.

구체적으로, 채취한 시료를 균질화 한 후 병원성 대장균과 함께 35℃에서 하룻밤 동안 진탕배양 하였다. 상기 배양액을 4,000 rpm으로 20분간 원심분리한 후, 상등액을 공극(pore) 크기가 0.45 μm인 필터를 이용하여 여과하여 시료 여과액을 얻었다. 상기 여과액을 이용하여 스팟 테스트를 통해 대상 시료에 병원성 대장균을 용균할 수 있는 박테리오파지가 존재하는지 스크리닝을 수행하였다. 그 결과를 도 1에 나타내었다. Specifically, the collected samples were homogenized and incubated with the pathogenic Escherichia coli at 35 ° C overnight with shaking. The culture solution was centrifuged at 4,000 rpm for 20 minutes, and the supernatant was filtered using a filter having a pore size of 0.45 μm to obtain a sample filtrate. Through the spot test using the above filtrate, screening was performed to determine whether a bacteriophage capable of lysing pathogenic Escherichia coli was present in the sample. The results are shown in Fig.

다음으로 전배양된 병원성 대장균 150 μL를 취해서 멸균된 튜브에 넣고 3-5 mL의 LB 탑 아가(top agar) [LB 배지(트립톤 10 g/L, 효모 추출물(yeast extract) 5 g/L, NaCl 10 g/L) + 0.6% 아가)]를 첨가하여 잘 혼합한 후 미리 만들어 둔 2% LB 아가 플레이트에 중층하였다. 실온에서 30분간 방치한 후 상기 시료 여과액을 각각 10 μL씩 점적하고, 다시 실온에서 30분간 방치한 후 35℃에서 24시간 동안 배양하여 박테리오파지의 유무를 확인하였다. Next, 150 μL of the pre-cultured pathogenic Escherichia coli was taken and placed in a sterilized tube and 3-5 mL of LB top agar (LB medium (10 g / L of tryptone, 5 g / L of yeast extract, NaCl 10 g / L) + 0.6% agar] was added and mixed well. The mixture was then layered on a 2% LB agar plate previously prepared. After allowing to stand at room temperature for 30 minutes, the sample filtrate was dropped by 10 μL each. Each sample was left at room temperature for 30 minutes and then cultured at 35 ° C. for 24 hours to confirm presence or absence of bacteriophages.

박테리오파지의 존재를 확인한 시료로부터 박테리오파지를 순수 분리하기 위해서 소프트 아가 오버레이(soft agar overlay)법을 이용하였다. 박테리오파지가 존재하는 것으로 확인된 시료를 식염수로 적절히 희석하여 각 희석단의 시료 희석액 100 μL를 취하고, 대상 세균(병원성 대장균) 배양액 150 μL에 혼합한 후 0.6% LB 탑 아가 3 mL을 첨가하여 잘 혼합한 뒤, 미리 만들어 둔 2% LB 아가 플레이트에 중층하여 방치한 후 35℃에서 24시간 배양하였다. 배양한 각 플레이트에서 형성된 용균반을 확인한 후, 이를 선택하여 400 μL의 SM 완충액 (NaCl 5.8 g/L; MgSO47H2O 2 g/L; 1M Tris-HCl (pH 7.5) 50 mL)에 현탁하고, 실온에서 4시간 동안 방치하였다. 상기 박테리오파지액 100 μL를 0.6% LB 탑 아가와 세균 배양액 500 μL와 혼합한 뒤 150 mm 지름의 LB 플레이트에 분주하여 중층한 후 완전히 용균이 일어날 때까지 35℃에서 배양하였다. 배양이 종료된 후, LB 플레이트에 15 mL의 SM 완충액을 가하고 실온에서 4시간 동안 천천히 교반하면서 박테리오파지 용액을 회수한 후 4,000 rpm으로 20분간 원심분리하여 상등액만 취하고 이를 0.45 μm 필터로 여과하여 최종 박테리오파지 용액을 회수하였다. 이렇게 얻어진 최종 박테리오파지의 용균반을 확인한 결과를 도 2에 나타내었다.A soft agar overlay method was used to isolate the bacteriophage from the sample which confirmed the existence of the bacteriophage. A sample of which the bacteriophage was confirmed to be present was diluted appropriately with saline, and 100 μL of the sample dilution of each dilution stage was taken and mixed with 150 μL of the bacterial pathogenic Escherichia coli culture, followed by adding 3 mL of 0.6% LB topa After incubation, the cells were allowed to stand in a 2% LB agar plate that had been previously prepared, followed by incubation at 35 ° C for 24 hours. After incubation, the supernatant was added to 400 μL of SM buffer (NaCl 5.8 g / L; MgSO 4 7H 2 O 2 g / L; 1M Tris-HCl (pH 7.5) And allowed to stand at room temperature for 4 hours. 100 .mu.L of the bacteriophage solution was mixed with 500 .mu.L of a 0.6% LB top agar and bacterial culture, and then the mixture was divided into 150-mm-diameter LB plates and cultured at 35.degree. C. until complete lysis. After completion of the incubation, 15 mL of SM buffer was added to the LB plate, and the bacteriophage solution was recovered while slowly stirring at room temperature for 4 hours. Then, the supernatant was centrifuged at 4,000 rpm for 20 minutes to filter out the supernatant. The solution was recovered. FIG. 2 shows the result of checking the thus obtained final bacteria bacteriophage.

도 2에 나타낸 바와 같이, 2-3 mm의 크기를 가지는 용균반을 형성하는 박테리오파지를 확인하였고, 상기 박테리오파지는 병원성 및 항생제 내성을 가지는 대장균에 특이적인 용균능을 갖는 박테리오파지임을 확인하였다.As shown in FIG. 2, a bacteriophage forming a fungus having a size of 2-3 mm was confirmed, and it was confirmed that the bacteriophage is a bacteriophage having a specific ability for E. coli having pathogenic and antibiotic resistance.

1.2 박테리오파지의 대량 배양 및 정제1.2 Bulk culture and purification of bacteriophages

상기 실시예　1.1에서 확인한 병원성 대장균 특이적 박테리오파지를 대량 배양하기 위하여, 1.1에서 회수한 최종 박테리오파지 배양액을 1.0×107 PFU/mL로 희석한 후 전배양된 병원성 대장균(STEC) 1.0×1010 CFU/mL과 혼합하여 MOI (Multiplicity of infection)가 0.001이 되도록 하여 35℃에서 120 rpm으로 9시간 동안 배양하였다. 배양이 종료된 후 배양액 전량을 6,000 rpm으로 30분간 원심분리하여 상등액을 수득하였고, 이를 0.2 μm 필터로 여과하여 최종 박테리오파지 배양액을 회수하였다. 분리된 박테리오파지를 “박테리오파지 EC121(Bacteriophage EC121)”로 명명하고, 2016년 9월 30일 한국미생물보존센터 (Korean Culture Center of Microorganisms, 서울, 한국)에 기탁하고 수탁번호 KFCC11691P를 부여받았다.In order to mass-culture a pathogenic Escherichia coli-specific bacteriophage identified in Example 1.1 above, the final bacteriophage culture recovered at 1.1 was diluted with 1.0 x 10 < 7 > After dilution with PFU / mL, the cells were mixed with 1.0 × 10 10 CFU / mL of pre-cultured pathogenic Escherichia coli (STEC) and cultured at 35 ° C. and 120 rpm for 9 hours to obtain a multiplicity of infection (MOI) of 0.001. After the culture was completed, the whole culture was centrifuged at 6,000 rpm for 30 minutes to obtain a supernatant, which was then filtered with a 0.2 μm filter to recover the final bacteriophage culture. Separated bacteriophages were named as "Bacteriophage EC121" and deposited on September 30, 2016 at the Korean Culture Center of Microorganisms (Seoul, Korea) and received the accession number KFCC11691P.

실시예Example 2: 박테리오파지 EC121의 전체 유전자 분석 2: Whole gene analysis of bacteriophage EC121

박테리오파지 EC121의 전체 유전자를 분석하기 위해, 박테리오파지 EC121 배양액에 20 mM EDTA, 50 μg/mL의 프로테나아제 K, 0.5% (w/v) SDS를 가한 후, 50℃에서 1시간 동안 정치하였다. 동량의 페놀-클로로포름-이소프로필 알코올 (25:24:1)과 혼합한 후 실온에서 12,000 rpm으로 10분간 원심분리하여 상등액을 회수하였다. 회수된 상등액을 동일 부피의 페놀-클로로포름-이소프로필 알코올 (25:24:1)과 혼합하여 실온에서 12,000 rpm으로 10분간 원심분리한 후 상등액을 회수하고, 상기 상등액에 3M 소듐 아세테이트를 전체 부피의 10%(v/v)가 되도록 가한 후 혼합하였다. 여기에 2배 부피의 차가운 95% 에탄올을 가하여 혼합한 뒤 -20℃에서 1시간 동안 정치하였다. 반응이 끝난 후 0℃에서 10분간 12,000 rpm으로 원심분리하여 침전물을 획득하였고, 차가운 70% 에탄올로 2회 세척한 뒤 에탄올을 완전히 제거하여 DNA 펠렛을 회수하였다. 회수한 펠렛을 최종 부피가 50 μL가 되도록 TE 완충액 (Tris-EDTA, pH 8.0)에 용해시킨 후 DNA 농도를 측정하였다. 전체 유전자 분석을 위해 PacBioRSII 를 이용하여 유전자 시퀀싱을 시행하였다 (마크로젠, 한국). 시퀀싱 결과로 얻은 박테리오파지 EC121의 유전자 맵을 도 3에 나타내었다. To analyze the entire gene of bacteriophage EC121, 20 mM EDTA, 50 μg / mL proteinase K and 0.5% (w / v) SDS were added to the culture medium of bacteriophage EC121 and left at 50 ° C. for 1 hour. The mixture was mixed with an equal amount of phenol-chloroform-isopropyl alcohol (25: 24: 1) and centrifuged at 12,000 rpm for 10 minutes at room temperature to recover the supernatant. The recovered supernatant was mixed with an equal volume of phenol-chloroform-isopropyl alcohol (25: 24: 1) and centrifuged at 12,000 rpm for 10 minutes at room temperature. The supernatant was recovered and 3M sodium acetate was added to the supernatant in a total volume 10% (v / v). The mixture was mixed with 2 volumes of cold 95% ethanol, and the mixture was allowed to stand at -20 DEG C for 1 hour. After the reaction was completed, the precipitate was collected by centrifugation at 12,000 rpm for 10 minutes at 0 ° C., washed twice with cold 70% ethanol, and then the ethanol was completely removed to recover the DNA pellet. The recovered pellet was dissolved in TE buffer (Tris-EDTA, pH 8.0) to a final volume of 50 μL, and the DNA concentration was measured. Gene sequencing was performed using PacBioRSII for whole gene analysis (Macrogen, Korea). The gene map of bacteriophage EC121 obtained as a result of sequencing is shown in Fig.

도 3에 나타낸 바와 같이, 박테리오파지 EC121의 전체 유전자의 크기는 168,805 bp 이며, GC함량이 35.5%, 전체 ORFs의 수는 277개임을 확인하였다. 분석한 박테리오파지 EC121의 전체 유전자 서열을 서열번호 1로 나타내었다.As shown in Fig. 3, it was confirmed that the size of the entire gene of bacteriophage EC121 was 168,805 bp, the GC content was 35.5%, and the total ORFs number was 277. The entire gene sequence of the bacteriophage EC121 analyzed is shown in SEQ ID NO: 1.

실시예Example 3: 박테리오파지 EC121의 형태학적 특성 3: Morphological characteristics of bacteriophage EC121

박테리오파지 EC121의 형태학적 특성을 알아보기 위해, 배양액을 2.5% 파라포름알데히드-글루타르알데히드(paraformaldehyde-glutaraldehyde) (4℃, phosphate buffer, pH 7.2) 고정액에서 2시간 동안 전고정하고, 완충액(0.1M phosphate buffer, pH 7.2)으로 10분씩 3회 세척한 후, 1% OsO4(25℃, 0.1M phosphate buffer, pH 7.2)에서 2시간 동안 후고정하였다. 고정이 끝난 시료는 동일 완충용액으로 수회 세척한 후, 에탄올 농도 상승순으로 탈수하였으며, 프로필렌 옥사이드로 치환하여 Epon-812로 포매한 다음, 60℃ 오븐에서 중합반응시켰다. 포매된 조직은 Ultramicrotome(ULTRACUT E, Leica)으로 초박절편을 제작한 후, 아세트산 우라닐과 시트르산 납으로 이중 염색하였다. 그 후 투과전자현미경 (CM 20, Philips)으로 100kV에서 120,000~250,000배 사이로 관찰하였다. 그 결과를 도 4에 나타내었다.To determine the morphological characteristics of bacteriophage EC121, the culture was pre-fixed in 2.5% paraformaldehyde-glutaraldehyde (4 ° C, phosphate buffer, pH 7.2) fixative for 2 hours, phosphate buffer, pH 7.2) for 10 min, and then fixed in 1% OsO4 (25 ° C, 0.1 M phosphate buffer, pH 7.2) for 2 h. The immobilized samples were washed several times with the same buffer solution, dehydrated in the order of rising ethanol concentration, substituted with propylene oxide, embedded in Epon-812, and polymerized in an oven at 60 ° C. The embedded tissue was stained with ultramicrotome (ULTRACUT E, Leica) and then double stained with uranyl acetic acid and lead citrate. Thereafter, transmission electron microscope (CM 20, Philips) was observed at 100 kV from 120,000 to 250,000 times. The results are shown in Fig.

도 4에 나타낸 바와 같이, 박테리오파지 EC121은 약 200 nm의 크기로, 정이십면체의 머리를 가지며 수축성 꼬리가 있는 마이오비리데(Myoviridae)에 속함을 확인하였다.As shown in Fig. 4, bacteriophage EC121 was found to belong to Myoviridae, which has a size of about 200 nm and has a head of a true twenty-sided and has a contractile tail.

실시예Example 4: 박테리오파지 EC121의 단백질 패턴 분석 4: Protein pattern analysis of bacteriophage EC121

박테리오파지 EC121의 단백질 패턴을 분석하기 위해, 1.0×1010 PFU/mL로 준비된 박테리오파지 EC121 40 μL를 10 μL의 5X 로딩 완충액과 혼합하고, 10분간 끓인 다음 12.5% SDS-PAGE를 수행하였다. SDS-PAGE 수행 후 단백질 전기영동 결과를 도 5에 나타내었다.To analyze the protein pattern of bacteriophage EC121, 40 μL of bacteriophage EC121 prepared at 1.0 × 10 10 PFU / mL was mixed with 10 μL of 5X loading buffer, boiled for 10 minutes, and then subjected to 12.5% SDS-PAGE. The results of SDS-PAGE and protein electrophoresis are shown in FIG.

도 5에 나타낸 바와 같이, 박테리오파지 EC121은 120 kDa, 70 kDa, 50 kDa 크기의 주요 단백질을 가지는 것을 확인하였다.As shown in FIG. 5, it was confirmed that bacteriophage EC121 has major proteins of 120 kDa, 70 kDa and 50 kDa in size.

실시예Example 5: 박테리오파지 EC121의 다양한 세균에 대한 감염성 조사 5: Investigation of infectivity of bacteriophage EC121 against various bacteria

박테리오파지 EC121의 다양한 세균에 대한 감염성을 조사하였다. The infectivity of bacteriophage EC121 to various bacteria was investigated.

우선, 박테리오파지 EC121의 병원성 대장균에 대한 용균 활성을 확인하기 위하여, ㈜옵티팜에서 분리하여 보유하고 있는 부종 유발 병원성 대장균(STEC) 균주를 대상으로 소프트 아가 오버레이법을 수행하였다. 그 결과를 표 1에 나타내었다.First, in order to confirm the lytic activity of bacteriophage EC121 against pathogenic Escherichia coli, a soft agar overlay method was carried out for Escherichia coli (STEC) causing edema induced by OptiParm. The results are shown in Table 1.

Figure 112016126853501-pat00001
Figure 112016126853501-pat00001

상기 표 1에 나타낸 바와 같이, 본 발명의 박테리오파지 EC121은 병원성 대장균(STEC)에 대해 높은 감수성을 가지는 것을 확인하였다.As shown in Table 1, it was confirmed that the bacteriophage EC121 of the present invention has high sensitivity to pathogenic Escherichia coli (STEC).

다음으로, 임상에서 분리된 항생제 내성 대장균인 ESBL 생성 대장균에 대해서도 동일한 실험을 수행하였다. 그 결과를 표 2에 나타내었다. Next, the same experiment was conducted on ESBL-producing E. coli, which is a clinically isolated antibiotic-resistant E. coli. The results are shown in Table 2.

Figure 112016126853501-pat00002
Figure 112016126853501-pat00002

(+: 용균활성 있음, +/-; 약한 용균활성 있음, -; 용균활성 없음)(+: With lytic activity, +/-; with weak lytic activity, -; no lytic activity)

표 2에 나타낸 바와 같이, 본 발명의 박테리오파지 EC121은 임상에서 분리한 다양한 항생제 내성 대장균에 대해 높은 감수성을 가지는 것을 확인하였으며, 이를 통해 본 발명의 박테리오파지 EC121이 다양한 분리원에서 동정된 항생제 내성 대장균에 대해 충분히 활용할 수 있음을 확인하였다. As shown in Table 2, the bacteriophage EC121 of the present invention was found to have high sensitivity to various antibiotic resistant E. coli strains isolated from clinical samples, and it was confirmed that the bacteriophage EC121 of the present invention had antibiotic resistance against E. coli It can be fully utilized.

다음으로, 박테리오파지 EC121이 다른 혈청형의 병원성 대장균을 비롯한 다양한 세균에 대해서 용균활성을 나타내는지 확인하기 위하여 ㈜옵티팜에서 분리하여 보유하고 있는 균주와 미생물 자원센터 등에서 분양받은 균주를 대상으로 소프트 아가 오버레이법을 통해서 감염성을 확인하였다. 그 결과를 표 3에 나타내었다.Next, in order to confirm whether bacteriophage EC121 exhibits lytic activity against various bacteria including pathogenic Escherichia coli of other serotypes, strains isolated from Opti Pharm and purchased from the microorganism resource center were used as softagar overlay The infectivity was confirmed through the law. The results are shown in Table 3.

Figure 112016126853501-pat00003
Figure 112016126853501-pat00003

표 3에 나타낸 바와 같이, 본 발명의 박테리오파지 EC121은 다양한 병원성 대장균에 대해 용균성을 가지며, 대장균 외에 다른 속인 Salmonella 종이나 Bacillus cereus , Lactobacillus plantarum 등의 균주에 대해서는 용균활성이 없는 것을 확인하였다.As shown in Table 3, the bacteriophage EC121 of the present invention has a tolerance to various pathogenic Escherichia coli, and it was confirmed that there was no lytic activity for strains such as Salmonella species other than Escherichia coli, Bacillus cereus , and Lactobacillus plantarum .

따라서, 본 발명의 박테리오파지 EC121은 병원성 대장균에 특이적으로 용균활성을 나타내는 박테리오파지임을 확인하였다.Therefore, it was confirmed that the bacteriophage EC121 of the present invention is a bacteriophage exhibiting a lytic activity specifically for pathogenic Escherichia coli.

실시예Example 6: 박테리오파지 EC121의 pH 안정성 조사 6: Investigation of pH stability of bacteriophage EC121

박테리오파지 EC121의 pH 안정성을 확인하기 위하여, 다양한 pH 범위 (pH 2, 3, 4, 5, 6, 7, 8, 9, 10, 11)에서 박테리오파지의 수를 측정하였다. 소듐 아세테이트 완충액, 소듐 포스페이트 완충액, Tris-HCl을 이용하여 각각의 pH에 맞게 조제한 후 990 μL로 분주하여 준비하였다. 박테리오파지 EC121 배양액을 1.0×109 PFU/mL로 준비한 다음, 상기 배양액을 10 μL씩 취하여 pH에 맞게 조제한 각각의 완충액에 첨가하여 2시간 동안 상온에서 방치하였다. 방치 후 각 반응액을 단계희석하여 소프트 아가 오버레이법에 의해 타이터(titer) 측정을 수행한 결과를 도 6에 나타내었다.The number of bacteriophages was measured in various pH ranges (pH 2, 3, 4, 5, 6, 7, 8, 9, 10, 11) to confirm the pH stability of bacteriophage EC121. Sodium acetate buffer, sodium phosphate buffer, and Tris-HCl, and the mixture was divided into 990 μL. The bacteriophage EC121 culture was prepared to be 1.0 × 10 9 PFU / mL. Then, 10 μL of the culture solution was added to each buffer prepared for pH, and the mixture was allowed to stand at room temperature for 2 hours. After allowing to stand, each reaction solution was diluted stepwise, and a titer measurement was performed by soft agar overlay method. The result is shown in Fig.

도 6에 나타낸 바와 같이, 본 발명의 박테리오파지 EC121은 pH 3-11의 범위에서 2시간 동안 안정한 것을 확인하였다. 이를 통해 박테리오파지 EC121은 pH 안정성이 우수한 박테리오파지임을 알 수 있다.As shown in Fig. 6, it was confirmed that the bacteriophage EC121 of the present invention was stable for 2 hours in the range of pH 3-11. As a result, bacteriophage EC121 is a bacteriophage having excellent pH stability.

실시예Example 7: 박테리오파지 EC121의 열 안정성 조사 7: Investigation of thermal stability of bacteriophage EC121

박테리오파지 EC121의 열 안정성을 확인하기 위하여, 40℃, 50℃, 60℃, 및 70℃ 등 다양한 온도 범위에서 일정 시간 방치 후 박테리오파지의 수를 측정하였다. 보다 구체적으로, 박테리오파지 EC121 배양액을 1.0×107 PFU/mL가 되도록 희석한 후 배양액 5 mL을 멸균된 튜브에 분주하고 30분, 1시간 및 2시간 동안 각 온도에서 방치하였다. 방치 후 각 반응액을 단계희석하여 소프트 아가 오버레이법에 의한 타이터 측정을 수행한 결과를 도 7에 나타내었다.In order to confirm the thermal stability of bacteriophage EC121, the number of bacteriophages was measured after standing at various temperature ranges of 40 ° C, 50 ° C, 60 ° C, and 70 ° C for a certain time. More specifically, the bacteriophage EC121 culture was diluted to 1.0 × 10 7 PFU / mL, and 5 mL of the culture solution was dispensed into sterilized tubes and left at each temperature for 30 minutes, 1 hour, and 2 hours. After allowing to stand, each reaction solution was diluted stepwise, and the result of performing a tester measurement by soft agar overlay method is shown in FIG.

도 7에 나타낸 바와 같이, 본 발명의 박테리오파지 EC121은 40-70℃의 범위에서 1시간 이상 안정한 것을 확인하였다. 이를 통해 박테리오파지 EC121은 내열성이 우수한 박테리오파지임을 알 수 있다.As shown in Fig. 7, it was confirmed that the bacteriophage EC121 of the present invention was stable for 1 hour or more in the range of 40-70 占 폚. As a result, bacteriophage EC121 is a thermophilic bacteriophage.

상기 실험으로부터 박테리오파지 EC121은 병원성 대장균, 특히 시가독소 생성 대장균(Shigatoxin producing E. coli, STEC) 및 항생제 내성 대장균인 ESBL(Extended Spectrum β-lactamase) 생성 대장균에 대한 특이성이 매우 높고, 병원성 대장균 내에서 증식함으로써 용균 활성이 우수하고 물리화학적 자극에 강하다는 장점을 가지고 있음을 확인하였다. 또한 본 발명의 박테리오파지 EC121은 사람, 동물, 식물 등 세균외의 다른 숙주에는 감염되지 않으므로, 항생제의 오남용으로 인한 항생제 내성균의 문제점, 식품 내의 항생제의 잔류 문제, 광범위한 숙주범위의 문제점을 해결할 수 있는 장점이 있다. 따라서, 본 발명의 박테리오파지 EC121은 병원성 대장균에 의한 감염성 질병의 예방 또는 치료, 항생용 조성물, 사료 첨가용 조성물, 사료, 소독제, 또는 세척제 분야에서 다양하게 사용될 수 있다.Bacteriophage EC121 is highly specific for pathogenic Escherichia coli, especially Shigatoxin producing E. coli (STEC) and Escherichia coli producing ESBL (Extended Spectrum β-lactamase), which is an antibiotic resistant Escherichia coli, And it has the advantage of being strong against physicochemical stimuli. In addition, the bacteriophage EC121 of the present invention is not infected by any host other than a bacterium such as human, animal, or plant. Therefore, the bacteriophage EC121 of the present invention can solve problems of antibiotic resistant bacteria caused by abuse of antibiotics, residual antibiotics in food, have. Accordingly, the bacteriophage EC121 of the present invention can be used in various fields in the field of prevention or treatment of infectious diseases caused by pathogenic Escherichia coli, compositions for antibiosis, composition for feed addition, feed, disinfectant, or detergent.

비록 본 발명이 상기에 언급된 바람직한 실시예로서 설명되었으나, 발명의 요지와 범위로부터 벗어남이 없이 다양한 수정이나 변형을 하는 것이 가능하다. 또한 첨부된 청구 범위는 본 발명의 요지에 속하는 이러한 수정이나 변형을 포함한다.Although the present invention has been described in terms of the preferred embodiments mentioned above, it is possible to make various modifications and variations without departing from the spirit and scope of the invention. It is also to be understood that the appended claims are intended to cover such modifications and changes as fall within the scope of the invention.

이하 본 발명의 박테리오파지 EC121을 포함하는 감염성 질병의 예방 또는 치료용 약학적 조성물의 제제예를 설명하나, 본 발명을 한정하고자 함이 아니고 단지 이를 구체적으로 설명하고자 함이다.Hereinafter, formulation examples of pharmaceutical compositions for the prevention or treatment of infectious diseases including bacteriophage EC121 of the present invention will be described, but the present invention is not intended to be limited thereto but is specifically explained.

제제예Formulation example 1: 의약품의 제조 1: Manufacture of medicines

1.1 주사제의 제조1.1 Manufacture of Injection

박테리오파지 EC121 1 × 106 PFU/mLBacteriophage EC121 1 x 10 6 PFU / mL

주사용 멸균 증류수 적량Sterile sterilized water for injection

pH 조절제 적량pH adjuster

통상의 주사제의 제조방법에 따라 1 앰플당(2 mL) 상기의 성분 함량으 로 제조한다.(2 mL) per 1 ampoule according to the usual injection preparation method.

1.2 1.2 액제의Liquid 제조 Produce

박테리오파지 EC121 1 × 106 PFU/mLBacteriophage EC121 1 x 10 6 PFU / mL

설탕 20 g20 g of sugar

이성화당 20 g20 g per isomer

레몬향 적량Lemon incense quantity

정제수를 가하여 전체 1,000 mL로 맞추었다. 통상의 액제의 제조방법에 따라 상기의 성분을 혼합한 다음, 갈색병에 충전하고 멸균시켜 액제를 제조한다.Purified water was added and the total volume was adjusted to 1,000 mL. The above components are mixed according to a usual method for producing a liquid agent, and then filled in a brown bottle and sterilized to prepare a liquid agent.

1.3 정제의 제조1.3 Manufacture of tablets

박테리오파지 EC121 1 × 106 PFU/mLBacteriophage EC121 1 x 10 6 PFU / mL

옥수수전분 100 mgCorn starch 100 mg

유당 100 mgLactose 100 mg

스테아린산 마그네슘 2 mgMagnesium stearate 2 mg

상기의 성분들을 혼합한 후 통상의 정제의 제조방법에 따라서 타정하여 정제를 제조한다.After mixing the above components, tablets are prepared by tableting according to the usual preparation method of tablets.

한국미생물보존센터(국내)Korea Microorganism Conservation Center (Domestic) KFCC11691PKFCC11691P 2016093020160930

SEQUENCE LISTING <110> Optipharm.CO.,LTD <120> Novel pathogenic Escherichia coli specific bacteriophage EC121 and antibacterial composition comprising the same <130> 34 <160> 1 <170> PatentIn version 3.2 <210> 1 <211> 168805 <212> DNA <213> bacteriophage <400> 1 ttaggccgca agggccttca tagttttagc gatttgggaa acttcatcat cactcaaaga 60 gctgcgataa ccgatgaagt cggaaacaat acggaatttc ttggtaaact cagcaaccat 120 tttatcactg ttttttgaag cattatttga taatacatca aaaagattag ttattgtcca 180 gatgtcatga ccgatggtat cttttccacc gttgaaatat acaccctgta atgaactaac 240 catattagcg agtcgtgtat attcttcaga aacttcatct atactgaagt acttcatcat 300 aaaatctaat tcaggatact taataatttt atcaatatat cgtttagctg aacttgaata 360 acctacatac ttatcataat ctacagcatc aaaagcatct acatataaat cacgtagagt 420 ttcaaaaata cattggcact gaccaagttc ttttaccttt ttctgtaaaa gtggacgaat 480 aacataaaat tcattaatgc caataagatt agccatacga gtcaaaatac tcgtagatgg 540 atgacaaagc gatgtagtac catccataga gaaaatatca gaacgatgca tatacgctac 600 ataaccagta atttcatctg cttctgatgt gagtgtaaac agttcctctt tttcccagcg 660 tccgtcttta atttcaaact taaatgcagt agcagcttta ggacgaggag ctttactttt 720 aactaccttc ggaatataac ttttaactaa agcttcaatt tctgacaaat aatgaatgtt 780 aacttcatca ctttcaaaca ttgccataat atcagggagt aaatcaatct gcgattctac 840 ttccggatta ataaacagaa gacgctcatt gtgatgaata tttaaagtgt tattaaattc 900 actatcatct aatgcacgtg ctaatccacg gataatatta acacgatttt taatattatc 960 aatgacgata ttaatttttg ttgtgttaat accaaacaaa cgatagcttg acgcaacggc 1020 tgaagtttca tgactttgct taatgcgttt cagtcgaggg tcaagattta cttcatacac 1080 aacccctgca ttgcataact tactgtcagg ttcaaacatg ctctgcatct tcttatatga 1140 cagattttta gtcgtgaatt tgaccgaatt actaatcata taatctcgag cagaataccc 1200 catcttcatc aattcacggt atgtatgacg aggagatgta gattctttaa atcgttttac 1260 atcttcatta aatgccttct cactgagttc tttaacacgc tcaataatat ttttacgagt 1320 acgatcatct aatgaaagag cctcacgcga tggagcaata tcaagtgaac ccattggaaa 1380 cttaatgtaa ttcacttcat tgcggatgct taaccagtta cggtctctaa taacaccatc 1440 aataggataa acaataccgc catagatagc gtacaatcca ccacgatctg gccaatatct 1500 ttctggattt acaccgtaat agtcatcaaa atccggaaaa taatcaattt cacggtcaag 1560 accattaatg atagccaaat ctttgaatgg tcgcatgata taagaaactt cataagcaaa 1620 gtttctaaag tctttttctt caactggaac tacgatttca ataccagttt tatcgtttgg 1680 acccatttct tttacgaatg taggtttaat ctgcggaccg tcaccatcca tgtaagctac 1740 ataaccgcga atttcacctt tatggtacga agtaatacta aacgtatcag tataactaaa 1800 cggagattta gaacctaaac caaatccacc aatgaaatcg ttagattcag ccttagatga 1860 actaaagtat gaattataca acccgggaga attatcatca ccttgaatat caaaatcgct 1920 catacctgga ccaaaatctc ggcaaacaaa tcgtggatct aaacgtccag gaacttgaat 1980 gataaatttt tcaggatttc cattgagagc atgggcatca atcatgttgg taatcaattc 2040 acggactact gcgcgaatct tgtttgtata caagtcagat gacagaattt taaatacttt 2100 aggagatgct gtgatgctaa atgcttttga tttagaacca ttaccaagaa ttgtttcttt 2160 ttcagtggtg ataatcataa tttcctcatt aattcatatt gcgtttaata acttcagcaa 2220 cttctagtag ttcatcttta gttgcggtgt cggattgaat tttatctcta atatccttaa 2280 agcggttttt aaactcttca gcttctccca tatcgaaaaa gcgttgaatg attctatatt 2340 ctcgatgaac tgctttatca aaaagttcta aatttacttt atatgatttc atttcaatat 2400 cctcatttgc ccaattaatt ataccacatc cttgtggtaa agtaaactac tggctcatcc 2460 attctttacg aaggtcagca ttatccccca tgagcatttc aaaaagctct ttccaattct 2520 caggaagttt aacaacatca tatactgggt tttgaatcat ctcacgatat tcagattttt 2580 ccaaagagcc aagtccctta atataacgga tgctatgttt aggtagagca tctttggcac 2640 tctcatattc agcgaccgta taaaaccatt cttgtttttt accgacctga gcgatgatta 2700 cgggagtttt gacgaagcga attcttcctt gttcaaacag ttctggccaa ttactaaaaa 2760 atccgagcag agaaggataa atgcttccta gaccatcgtg gtcagcatca gtcataatag 2820 caatattatg ataattcaag ttttcagcct tttcaccaag aactaatcca gtgattgcgc 2880 aaatatcaaa cagttctttg tttttaagca tatcagcata tgacataccc caactgttga 2940 gaactttacc acgtaatgga taaccgccat gaagttcttt atcacgaaca tcaataagat 3000 atccgatagc agaatcaccc tcagtcaaga aaagagtagt gtcagcgtct ttaccgcaaa 3060 gattcgcttt aatatgttta tgaaccttag ctttagaagc ctttttagct gctttagttt 3120 ctgctgcctt ttctgccgcc aatttacgag ccaaagcagc ttcaataatt ggcattaaaa 3180 ttgcttcatt atttaaaata gcacgtgaaa tctttttagc atcaagctga atatgactac 3240 gaatttcacc aaatggagaa gtcaaacgct ctttagtctg agaatcaaat cgcatgtttt 3300 tcatatcacg aacaaacata acgatagtca aacattcttt aacccgtgct ttagttacat 3360 caattttgaa cttacgtttg atttgtggaa taaggtcttc acaaatatca tccataacgc 3420 agtcaatgtg atggccgcca ttcttagtat gaatgttatt aacgtatgtt aattgacgaa 3480 aaccatccag tgaacgacca atcgcaatag aacaattttc ttgttcttga acgatagcat 3540 gctcatcata ttggcgtgcg tatttcttaa aattgccctg aaccttttta ccattaaagg 3600 taaattgaat atcaggataa actactgcaa gtgtctggag acgatctagt gtaatgtcaa 3660 gataaacctg agatagctca ttagtttcaa atgacataaa atcaggaatg aaagtaacac 3720 gagttccttt ccattttcca ggaatagttt cccatgattt attttccatg ccatttgaac 3780 aacgaactac aatattattt tgaccatcgc cagtttcacc gacaaacatc acagaaaaaa 3840 tgttagttaa actagaacca acaccgttca taccgccagt gacgcgttct ttatcatcac 3900 cgaagttacc acctgctttt ggaatagtcc aggcggcaac aggaccagga atttcttcgc 3960 cagtaggtgt tttaaccatc gcttgtggaa taccacgacc gttatcttca acagttactt 4020 gattgttttt aatagtaaca ttaattttat tcgcgaattt aaacttagta cgaatacctt 4080 catctaccga gttatcgata atttcatcaa taagcttaac aagaccaggt acatactgaa 4140 cactttccca tttaccaaac agaaagcgct catgcatttc attagcggaa gagccaatgt 4200 acatgccgct acgctttttg atatgttcaa tatcgctcag aattttaatt tcattcttaa 4260 tcatcactta tcctcgtttg gtttcgggaa tattatactc cggtaatcat aaagctaaag 4320 gcccgaaggc cttttattta aaacggatag tcgaatcctt gaagaataga ccagaacata 4380 cggttccttc tactttctgc ccggtaggtc caatagcacg aaatccagta tgttggaaat 4440 cattttcaga gcaaccgaac caattgtatc cagtgatttc aatattagta aaaccacttg 4500 aagataaaac tttggttgca ttatcagcat cagtacatcc tgctaaagac actgctaata 4560 ctaatgctgc gatagaacga ttaatatatt tcatagtttt cactcaaatt taatggcttg 4620 aaggagacta ataattctca agcgacttct ttcatcttta actgtaaaag aaagagggtc 4680 gccagatttc atagtgatag tgcattcaaa atcaaaatct tcaggaactt cttcgaagaa 4740 gtcaaattct tcatcataaa ttagaacttc actccgcaga ctgtgaagaa tttttccagc 4800 atttctgcta gttgctgtac taatcattgt aacattatga cctttcatat cttcaacgat 4860 aaattcgctt gtagatatta cggcattaat agaaccattc ctattactag cagaaagtag 4920 atatttcttt tcttcacctt cgcgaatgcg atatttctta ccaattttaa acataattac 4980 cctttaagta agtcgtaaaa accaccattc acatgcttag gagcggaaac taaccgaata 5040 gcaacccgat gacaatcagg acatacatca gtatcccttt cagaaatttt cttgattttt 5100 tcgtattctt ttgcacagtc tttggattga catttataat cataaagcgg cataattatt 5160 ccttaaagtg agctttcaac atctgataca aagaccatgc ctgtacatta ttttcaatag 5220 taacgttcat aaccgggaat tcagatggat cagttattgt tgcagattct tcctgctctt 5280 cagctgcctg gtatggattt tcaacttcat taaagaattc agcttcattc gatgaaagcc 5340 aaataaaatc ttcatccaaa atatctttac cagaagatag tactaaattt ccagcaaatg 5400 acataatttt aataggacgc ccaagagcat ccacatctaa aattttaaaa ggatgcatac 5460 ctaaacggcg tgcatagatt ccgttatcag tatggtcttt aataaaattt tcttgagctt 5520 gtttattttt aaattgatac catttattaa cttcaaattt aatagccatt aataaatttc 5580 cttccagtaa gttgtaccat cttcagtgat ttcacgaaat acaccgtaaa ttggttgttt 5640 atccccaacc ttttcataca cataaaccga agtcaagtga gtaaacttag cagtgtgttc 5700 cttttgaact actaccaaat ctggatcgaa taacacatct tcaaattcgt cattagtgca 5760 gctctgaaca attttacgtt tcattacaat ttcctcatta attgaacatt ggagcgatgc 5820 gtttcagaag agtagcagca cctttggcaa attttccatt ttattctcca agttattttc 5880 tgtatcagta gttgatattg atatagtacc ataatcaact actgatgtat acagttttat 5940 gaaaaaattt taaactttat gcatagagag ctttgctata gtgtttaatc cagctttcag 6000 gaatgacttt gtatgttcct aaaaatacca cattatacag cttaacaccg tcttctaccc 6060 actgatcggt aatgtatgcg cacatagcac gagtataaac agccaaacca tcatctttga 6120 taaatttaaa ttcacaagga gcaatgaact taatagcctg accgagtttc cacttaaagt 6180 ctacacctac atgcgaagta tcaatcgttt caattccttt agcaggaaca gctttcaaaa 6240 acgcagattc aagaaatttc gcacgaacat agccaaactg aggtttagac tttccatctt 6300 taggaatgat acgcactttt acttcagaat cttcatcttt aacgccgtgt ttaagctgaa 6360 tgcttacaat ttcgaccaat tttcctgctg ctttagaacg ggatttatca gatacacgag 6420 caatttcacc aatattaata atcatagtta tctctcactt gttaaaaaga ttttatactc 6480 cacaggacca ttatactctg gtcccaagag tttgtaaact attaattcaa aatagctacc 6540 actgcactac gaggtactac gctaaaatca cctgcatgaa caacgttcag aagttcaaca 6600 ccatcttcaa tccattggtc tgttacccaa ccacagaccg aaataaatgg agtcttgata 6660 gctactgcac gagtcaaaag gtcagtagga tcaacttctt tgaagaggat aagctctgct 6720 tcaaagacta tagttttaat tacttcatca ttatctaagc gatgtgctcg aatcacgtaa 6780 gctttattct tatcatacca attacttttt gaaaaacttt taaccacaaa ctcgccttca 6840 ccaaaaacac tagtcaatgc tttataaccc aaatctagtt cagtagtttt aatttcagtt 6900 tcaaccagtt tgtaggtttt gccaatttcg atggtccgag cagtcataaa ggtttcctta 6960 atttctaatg gtttaacaag agtgccgtac atgcttgcta tatccatatc aaatatttta 7020 tctataggat ttgggggtgt attcaggatt ataattaaat ttcataatta tctcatttca 7080 ataaaatcta caagttcagc atgggatttg cggaacatta cttggtgtcc gccaatgata 7140 acttcatctt caggaacttc ataaatcgca atgtacattc cacgatcttt taagtcttca 7200 cgctcttctc gggtgaacca tctcatcata tcatattcac tagcgaaagc aaaatggtat 7260 aatgcaataa accgcgatgg aatatacttt tcagacggtg aataattttt atcccattta 7320 gttttaatag cattattagc attttcaact aataacttat catcgtgtgg aataggaata 7380 ctttcatggc tttcataatt atcgctatga tgatgaaatg acgatgaatt aataccacaa 7440 aattttagcc aagttcgagt tttcatagaa tcaaatccac gataaggagt tgattgcacg 7500 cataactctt gcctaatttt cactatacca ctatcatcat ttaatgcgct aaacgatgat 7560 tcaacacgat aaattttcat tttattatcc tcagtagcta tggtgttata ataccacaac 7620 taaccgagga agtaaacaac tttttatcgt tttgttggaa gagatagagg atcgcactct 7680 tcctctgacg gagcatcttc aagacccata gcataccgca aagcatactt catcatcagg 7740 atgtctttcg cacagtcatg aatagaatca tgcgcaacga acccgtctaa agttcccttt 7800 ggaagaggac atgtggtcat atcacgaaca agcagaagtg cttcaattct ggtgcgaata 7860 tcgcgttgat tccagaattt acaaggttct aacttaaacg tatcaagctc attctcggaa 7920 acgccgttaa gacgttgaat atcgcgaatg agatcaacta aaattggaaa atcaaacgac 7980 attccacggc accagccctg agatttccaa ggatcgatat tatgcgcatt gatgtaatca 8040 ttaaattttg caataccatc gatagtgctt acatcttcat ctgatggcgc aatatttttt 8100 cgagcttcag gagattgatt tttccaccat tcgatagtgc ttttagtaaa aagacgatgt 8160 cctttttggc tttttaaatc aaatttgatt ttaatgccgc gtgaaactaa ttcatcaaat 8220 gtttcaacta cttctggatt agggtcaaag gcaataacag ccaaatcaat aacagctgcc 8280 ttttcaccgc ttcccattgt ttcaaaatct ataataaaat caaacattaa attttcctcg 8340 ctaaatcgcg aatttgacct acagtataat cttggatata aactttatta ataggctcat 8400 caataaattt tgccatagat tcaatatctt tttgtatctc ttcaagactg tatactatct 8460 ttaaagcttt ttcgcgaata gtaacattat caggtcctga attttcttgg atgacagctt 8520 taacatttgt cataagagat ttaaactgct gcaaacttaa ttcaatcatt aataaccgcc 8580 ttataaagat ggctaatttc acctaaaaca taatcactga ttgtaacagt tttcacttcg 8640 ccgcaaaaga attctaacgc aatcaaatct cgttcaattt cttccaattg aagcattaac 8700 ttgcctgatt caattttcac gtttttgcga tttttactat aagctatttc ataaatttcg 8760 ctcactttat cttgaagcag ataaaactgg tctttagtta tttccacgaa tagcttcctc 8820 aaatttaatc agcagcttac agacactttc atctaatgta attaccgtgt ctgtattact 8880 atgatatgat tgtttttcaa ttcgtttaat tgctagtata gtatcactta taagattaag 8940 cttataaagg agctcagctc ctgttatcat aacactgagg ttatcttgct tatcagtatg 9000 cttctttata ccatctatta gacgatttaa atattttgaa ttgatgttaa tcatatatcc 9060 tcacacataa aacacatcat aacgaccacg agtgacacca acataaagaa gctgctgagc 9120 tagttcagca tctgcataat gaatacaagg cgtatagatg aaagcacggt ctacagacat 9180 gccctgagct ttatggaatg ttgatgcagg aagtgctttc actttactaa actgtgattt 9240 agcatcccaa aaatcactcc acggagcttt tccaccttta ttccaatttt tatacgtttc 9300 tgccgtttta cctaaaaata agttaaactt atacagctct tcatcagatg aaattatttt 9360 aatcttttca cgataatatt catcatcgcc gtaagtttct actgttaaat cccaataacg 9420 aattagatat tctccagaaa caccacgagc tttaacaaat gttgatgtat actctgcttc 9480 tataatacga actaattgtc cgttattaaa aataatttct gacacaggct ttccatcaat 9540 tttatatgtt ttaattaatg gttcctgcat tacaataatt tcaccaacga taaaatcttt 9600 atcagtttca aaaatctttt tgcgaataat gctatttaac ttgtcgacag atttattcgt 9660 aaatgccatt acgcgatttt caaacaaatc atctagcgat tttacgattg aaaaataatt 9720 taccataaaa tcgcgtaaag cggtatcacc agtaaatcca cgtactccat gcccgtcaac 9780 aactttatca taaatccact taccgttgcg aacatcagta gctacatcaa taataggagc 9840 attactgcgt ttaacttcag tgagttcaca ctgataaaaa tctttatgcg taaagaatgg 9900 actgatataa gcagtgtttt ctcctgggtc aacaggtcta atttgcttat tatcgcctat 9960 tccaattata gtacaccacg gcgggatagt tgaaagcaga attttaaata gctttctatc 10020 atacattgac acttcgtcgc agattaatac tctgcattta gctaaatccg gtacttcttt 10080 ttgttcaaaa agaacgtttt cttcatatgt taccgggtta attttgagaa tactgtgaat 10140 agtactcgct tctttccctg acagtttaga aagaatcttt ttagctgcat gagtaggagc 10200 tgctaaaata atgccagttt cgcccgtaga tattaaggct tcaatgatga acttagtaag 10260 agtagtctta ccagtaccag caggtccatt aatagttaca tgatgtttct tttctttaat 10320 agccctcata acgatgttaa aggcattttt ctggccttcg gtcaaatcat caaatgtcat 10380 cgtaaattcc ctgcaattgg tatactaaca atacgcccag tatctaaaat tcgccgatat 10440 aatctttgtg tgtctacatc aggcttaaca tgtttaactt ctattttatt aaaccaaaac 10500 ttgcgtggag tctcaactaa tctcggaatt cccataccta aagctagtcg atactgatct 10560 ttaagagtgg taaatacttt atcagcaatc tccctttcaa aaaatacagc agggcggtgt 10620 tcatcaagag gaacaggcac tgcaaatcca tctttgtctc tatacactat cgcatataca 10680 taaaacatat tatcctcgga taagtttaaa aattgaacaa tttagcgggt atcctctttt 10740 cagtttaagt ttatcaataa aagacaagtt ttgataccgc tctacacctt gaataatttt 10800 atcacacata tcatattgca tttctgcttc tgacaacttt ttcacagttt tccaatcaga 10860 gcctttaaga agaacgttca atttaacaac ttcagcgcct tctgctatac gagaaccatc 10920 aatacgagct ttgagtgcta caatcgttag cttaatgtca gaggtttgtt ttgatttaga 10980 aagctgagaa atgtgttcaa ttcggttttc acgttttttc tgtatagctt taatttgatt 11040 ataagtcttt ttgattttag cccatttctt ttcatctaaa tttagtttat gaactttttt 11100 cgcagatgaa cgaccaattc gcaaagcaaa taaatcacgc ttttcaatca actcttctaa 11160 agtataatca gaacgaaatg tattatactt tttctttact gcaataacat tccctttaat 11220 gtatccaacg ttattatcaa aacgttctaa tgataatttc tctccttcaa tacgattatc 11280 aaaaggttct cctgagtaag cgcaaacttt ctggtctaaa atgttcttaa tgtaattgaa 11340 gtctaagtta aaatctttag aacgtctttt tgcagatgcc tgagtatgct ctaaacgacg 11400 tttaatttta cgaatttgat tattagacag tttcatattt ttctcacatc ttacggacga 11460 ttgactacta tactataaca tttttacctt ggcttgtaaa caactttatg caaaaatgct 11520 ttaaaacttt cgtggtataa tgaatctaag tccttccatt atagattaaa tccttcaaaa 11580 tcaagagtat agatagtgta tgttgaatac tttttatact catatctatc tgcaattcta 11640 aatacacttc cagctggtat cattacttcc tgttcatctg aaactaattc catattacga 11700 taacgatggc tatctggaaa cttaaaactc ggactatatt ctttacaacg tagagctttt 11760 atagcatact cctggaaatt aaacaccata ggagctttga attcaaaaat aacttgtgtg 11820 ttgtattcta atccagaagc aaagtgtaga gctatatttt tatcatatga agctgatact 11880 actttatcaa atgtaataat atcaattcct tgatttaaca cctgtttagt ctcaactgga 11940 acacctctcc aaagaggttt atcgtttgga accaaacgag atttgattat ttcatttaac 12000 caagaatgat cgtctggctt attagtaata caatgaatta aaagttcaat ttcggataaa 12060 ttaaatcctt cagaaagtaa ttcttcacga atagaagcac gcaccgatgc atccattgat 12120 ttgattttaa aatcttttaa ttgcattgct gaatatttca ttcaactacc tcaacatcat 12180 acactttaaa tgttccaaat gaatcgtgta atttttcttt tgaaatagaa gttattttat 12240 actttccaat tggaatcatc cattcttgtt cacgtacaat catcattaag ttatcagtac 12300 gttctgaatc taatccatca gtatcttcat atgtatactt aaactcagta ttaggagaag 12360 aaagtataat atcgctgata tggtcagaat aattaaaagc tttatcagtt tttaagcgaa 12420 atattatttc agtggaatat tcaacataag aaaaagaaca cgctgtgtgc aaactagtag 12480 taaatgaatc tactctgctc gttgaaaaca cttctccgac ttgtaaatct ttaatgagtt 12540 cttttgtcga ttttgatata ccacgatata gctgataagg cgatttagtt aaatgctttt 12600 taacgatttt attcaactgc tgatgaagag cttcattctt tttggcttcc atacattgcc 12660 aaagaattga ctgttcaaag tcagtaaatt tttcacagac ctttttatac atatcatatt 12720 gaaaatcgac actttcagct tttatagata actgttcaac atctgcaaga ttaataatca 12780 tgatagcctc cgtatacttc agaagctatc atatcattgt taggaaggaa agtaaacaac 12840 ttttttgaat tattttgccc agggagccca gggcggaggg tcaagatggt atgaagctag 12900 ttcttctaga agagcatctg gggcttcaat tccataattc tgtaatacta tacggtactc 12960 tttcttataa tcactagaat cattctggat attcgtagaa tgattatctt ctaacatctc 13020 aaataaatcc atattaattc ctagcgataa aaaccaaaat gacgattagc ttcaataatc 13080 tttctttctt cttcggacat tctccagcgt agtccaacat caaaatgagc ccagaccatc 13140 ttaacaaatg catttatatc tttaatatct tcaataatga atgttttact tttataaggt 13200 tgactagcta atttaacttt atcgtcttca aacaggtcaa aaagaccata ttcatgagct 13260 cttttatagc ctttaatagt taaagcttca gaagaagaaa acggtgaatc agtattccgt 13320 aaaatatctt cagtatgctt tataattaga ataacatttt ctggatattt tctttctttt 13380 atatctttaa ttaaaagatc cggattttct gctaaaggaa taattaatga acacttttta 13440 tcaagtgtat ttactgattt accttcttta gacataaatt ctattgaata acgttttgct 13500 acttcaatca tgtgatttcc ttttgcctac taatggaccg tcaggaattt tgttttcctg 13560 aatgtatttc tcattttctt ccatcatttt actgccaatt ttaagaagca aatccattgc 13620 ttcatttgct ttagctttag cctcttctaa cgtcatatct ttgttcatga tttatcccca 13680 tagatgtctc tcatcaattt aagcgctgag cgttctaatt tcttttcttt ctcagcacta 13740 atcattgatt tcatccattc ttctgattcg ttctgcattt ctttatttac ttgttcaacc 13800 caaccatcat caatatacat tgagtttggt ctattgaacc attcaagcat cttcttcaga 13860 actttcattt gttttaccta aaacaatagt aggagcatcg tcaaatttat gaatttttag 13920 taaatttgga tttaaattat tccataaaga ggtaataaaa tatgatagcg cattttcttc 13980 tgtaattata aatttatttc ccttatctat tttccagtca tatattgaat catatgaata 14040 taatggcaat ggtttattgt tataatatga ttcagcaaca tcaatatagt tagatttagt 14100 aaatgcttga attgacataa atggagaatt tcgtacagtt tcaataattc cgatcttttt 14160 aagttttatt tcaacatctt ctggaactgg cattgaaata aaatcttcta ctagatacat 14220 gttattatca tatcttttat caatcattac tgctacggta attggaacgt ctttagcaaa 14280 cgacaaacta ttactgctaa tatacatttc aaacaaaatc gcttccataa ttttcctcaa 14340 tcacaagatg tagatgaaca actagaatca caagaacttc cacatgaatc gcccgtccat 14400 acatgaacag gaacattagt gtcatatgaa tcagaactag actgtgtatt ctgcgtatta 14460 gatgatgtag gtgttgacca acgccaagga tttttataat attcctgggc ttcttcataa 14520 gtcatagtaa ctgcttctac tgttccatct cccatataaa catattcaac tacagttaaa 14580 ggaaggtagt catttgaaat aggaactaca ccttctcccg gagtcgtaga gaaaaaatcc 14640 gtaaagaaac ttttaaacca attaaagata aacattacaa aaagcctctt tgaaattcga 14700 ctctttgaaa tccaccccag tcagtatatc gcatttcagc attgaactcg actgaaccat 14760 ctgcatgcat catgaatgaa tgcgtgacga tatcacaatc ccagcttttc ataccccatt 14820 tatcagagat agctttatca agaaccttct ggaggtcttc atttggttta atccaacgat 14880 ttaacatagt gctctcctct ataagataat tctattatac catactcatt gtggaaagta 14940 aaccggtaaa atgaaaaaag gactcccgaa ggagtccctg aattattaac caccagttac 15000 tttccacaaa tcttcgtttg cagtaatcca tgcatcacgt tgattttctt cgtatacagt 15060 agtatatgct gctttttctg aagggaatgt ctggtaatga gcgccagaaa ttttgtgaac 15120 gtcagaataa agagggaaag ctacagaaat ttcctttcct tcaattttct tatttccgtc 15180 taatttctgc tcaaatgttt taatattaac ataaccgcga gtactagcca tgtaattctc 15240 cttttattta aattacatga ctatttataa taaattctca cagcttttaa gccgtcgttt 15300 atattaataa cctcggtctt gacgagcgaa gttttcagca tttttcagat aataaagttt 15360 aaagatttct tcagccgtaa gaccgagacc ttggaacatg ttcagaacga aatgaagaat 15420 atcaatcatt tcgaatttaa tttccaactg gtcttgtgga gataaatcag taatcagagt 15480 ttcacgacgt tcaccgtgtt gcgacttcca aggcttccat acagcagacg catctttttc 15540 gccattgctc ataccaccaa gagaagtcag aagttcgcgg aattcatcat caatataatc 15600 tttctgatta cgcagccaat caacaacttc acctgcagta gccaaatcat caggatgacg 15660 gttatattca ggtttatctt tagctaaacg aacttgcaga gatttctgca tatcaagcat 15720 aacctgcagc gggtcttttt catcaccgag aatatcccag tattcatttt gagctttatc 15780 agcgccttca atcagttgac tacattcgtt aaagtatgcc attatttttc ctttcaattc 15840 atgggttagt agattaatta tacaataaat atataaagca ataaggagga tatatggtac 15900 aaaaattaat ggcacttgtt aatgccataa aaggtaataa aaaacgtata gcttttacta 15960 tttctgctat ggtaggaatt ttactctgga attttgtttt atcaccaatt gctattgctc 16020 atggtgttaa tattccagta attactcttg atacattcgt agatttagca tttgctttag 16080 ttgggttaat ttaaatctta gcatatttag atagccgcat tttagccatc aacccttgag 16140 caatattatt tttcatatat tccataattt gttcaggggt tgcaccttcc tttctaatca 16200 tatcattaac atcttttgat ttccagggag atttgtccca aaacataacc ctttctcctg 16260 catcaactaa tttagtcatt cgtttaatag tgtcagggtg acgaggttca ttatctaaaa 16320 cccatacacg tctatcttta aatggaacaa tttctaggtc taattgacca cccgtaatag 16380 ctataccatt ttcaataaaa agtgaatcta taggtccttc tagaacatat acatcaccat 16440 ctttgactcg ttcaactcca tagatttttg ttgcctcagg ataagctttg atggtgatat 16500 atttttgagg agcatctttc tttaatgcac gtccttgaaa agactcggct tttccgttag 16560 cattataaat tggaataaca agacgaggct cgggcatttc ctttttatat gttcctggcg 16620 ctatactatt aactaattta ggccattcgg ttgtaaacca aagatatttc catttatcct 16680 ttggaataca acgagctttt acatatttta taattggatg gtcttccgcc agtttatcta 16740 gtctaatgca tgacggaaga gatttaatta ttttcttctc aggttgttta gaaagttctt 16800 taggtttttc tactggacga cttttacctt tttcttttct tatttcaaag atatactcac 16860 gatataaatc aggttcaaac tcctttaaat atattccgat tggtgcatga tagttacagt 16920 tataacaatg aatatttcct tcattattat cgccataata ccatccacgg gctttatttt 16980 gatcggtttt tgaatctcca caaacaggac atctaaaccg taatttaaaa gttgaactat 17040 tatttacttg tgcgaattta ggtaaatgag ctaatgcacg gtatgcaaac tcattatcaa 17100 tccaaggtat tgatgacatt tttactcttc tttttcttta gattcctctt ttttcttttt 17160 aggaatctgt tcaggacctt tatttactac agcgcctgac gttgttccag tggagatatt 17220 ttcaggatta ccacctgaat ctccagctac catatcttct ttgataaatt ctttatatgt 17280 tttcatatta acctctattc ataaaagcat taaaaatttg gtcatcaata gaaacattta 17340 ctttagactg tttttctgat ggtaattcat atccacatat tacaattttg tgatcaatat 17400 caaaatacac agaagcaata tgattaatga tgttttcagt aaagtctaaa tcaacatcaa 17460 tatctttttg accacagccc aaaggataaa taatgcgagt aattcgatta tctttaacaa 17520 agattccacc gatatactct gtgctgcgtt taaagtctac acgccgacga aatgaaaaat 17580 attcaggctc tttatgagct ctgctcatag gacacaacga gtaactagaa taagagatgt 17640 caaatcctac gccttcgata tgagccaaag tgtcatgatt aaaccaatta taatcgtacg 17700 ccaaatccat tagattataa tatgtaaagg gcaccggatt aacatcatta gtcacaagca 17760 tgtaattagc aactgctata atttcattgt ttttaacgaa tacaaaccgt gattgatgtg 17820 aatgacctgg acccgcgttt tcacgattaa tgatataaca ctgggcacct ttatatttgt 17880 atgtatcttt gcacttgtgc atttgataga gcattattca cctaccactt cagcgatgat 17940 atttttatta ttaaagtttt tatcgcaata cagaacataa ttatactgca ttacaccacc 18000 agacttaagc tgtttttgca cttcagcttt catttcagga cggtcacgct caacgatatt 18060 cataatatct gcttcaattt gagtttcaac ttcagtctga tctgcagtca tagaccactc 18120 gcacaaatct ttgtcataac ccgccatagc aggctgagca gcgcaagaag ataaagcaaa 18180 aattgcagca aagataaatt ttttcatgat aatctcctca gtagtttatg tttatatagt 18240 atctcaattt ccaataaaag taaacagtta ttttaaaact tctgcataat cacatgttac 18300 aaactgtttc tctaacttgg cgattttacg aaagtatctt ttgcattgac gaatctgtcg 18360 cttcgtaggg cgcacagcaa acttaataaa ttccactcga ccaaatggag gactttcttc 18420 tgctggaata tctaatacta attcccacgt atctgcaata agtgctttga attgagtatt 18480 tttcctaaca ttatacggag taggtttaaa taaaacgata tgcatattat cctcggcaat 18540 ccacttcgca tactttcttg tcatcaatga aagctttaac tagtgcttta ttaacttcag 18600 catattgatt agtagcccag tgaacgtcat ctttcatcat tgtgatttct ttagtaaaca 18660 tgctttcatt cttaaaccac cccataaaaa ctacctttac caattccata acaatctcct 18720 catttaacca acaagactac tataccatag tcttgtcagc ttgtaaacta aaattttaat 18780 tcatttgcca aagcatctaa ctgagctcga gcggattcgt ttctttgata gcgattctgt 18840 tcagcttgaa tctgctgtga acctgctact tcgttcactt cagttggagt agaatcttgt 18900 tcaatttcta cccatttctg atttcctttt tgaacaccca tcaaaaactt attccattta 18960 ttcttatcac cgtatcgtga tttgatttgc ttaatgagtt gttgttcagc agctgctagc 19020 tcctcggttt caatgaccgc aagcataaaa tcggctgttg ctggaagacc ggcagattcc 19080 gcaatatcgc tcatgttaac atcagaagaa tcccaagctt gcttaccaac ctgtgctgca 19140 gtccaaagaa cggtttcggt ttcaacagcc agagcacgca attcctctgc gatagcttta 19200 acagttgtgt aactattttc tgaataaact ctgatgcggc aagatttaca aatacctaga 19260 tagtcaacaa taatgattgt tggaacaaaa ttcttcttga gctttaattc atttaaaagc 19320 gaccgaaatg tattagcgtc tgctccacca gtaggatact gtttaacgat taaacgaccg 19380 agagtagatt tctcacgcca tttttccatc tttcctttat actcagcgta agaaatatgc 19440 ccatcatcaa tgtcatcaag agaaacatca agcatattag cgtcaatacg cttagcacaa 19500 acttcttctg ccatttccat ggaaatgtaa agaacattat gtccgagctg caaataatct 19560 gctgccaatg aacacagacc taatgactta ccgacgttaa caccagccat taaaacgttc 19620 agtgttccag tttcagctcc acctttagta attttgttta gaattctgag tttaaatgga 19680 actttacgag ctttattcat ataagatagc cagcgtgctt cgtagtcatc catccaatca 19740 tgaccaacgt agctatcaaa tgaaattgat aatgcttggc gcatgatgtc aggaatagca 19800 ccaacgtccg gcattttctt atttcgtttt tccggaggaa gctcagcatt agtttgaatt 19860 tcgattattt tagacgtagc attaaacatc gccctttgct gaacatattt ttctgtttct 19920 tttattaacc aactgtggtc ttctggagaa tcggctagtt tcgaaataag tgtttttaca 19980 ccagaatatt ctgtttcagt aaatgaacta ttttctaatg caacatttaa cgcattaata 20040 gatggaacgc tatggtactc attaacatga gatttaatta atttgaatgt atttttagct 20100 ggaccacttt caaaatattc tgaatccata tatggccaaa cttttgaaaa ataagcttga 20160 tcaaatatga gatgagaaag aataatttct accacactta ctccttaaaa gaatttaaat 20220 tttttctttg accttttatt aaatgcatct tgtagttgca ttgtaataca tttttctaca 20280 tgaggagcta actcagcttt tctttcttgg tcaagaacag caaagtccat tacgactttt 20340 ccatcaaccc aatctaattt tgtcacatac acaatgtgtg tagaaccgtc ttctagttta 20400 atgacaatct cctggataac attttccatg gcagatttaa ttatcttaag agattcatta 20460 aaaagacgtt cttttctttc ttcttccccc tccgaagagg gggattcatc gataatttct 20520 agatctaaat ctaaatcatc tttattcatt aaattcttcc atatcactta actgatctag 20580 gtcagtttct aaatcagctg ctgatttact tttactttct ggagatttaa atttttcaac 20640 ctttgagtta atcaattcat caacttcagc ttcaacaatt tcattactat caatagcacc 20700 taactgataa gcacgtttaa tagcatctcg gaatggttga tgcttaaata aaggacccca 20760 gaatgtagtg caattggtat cttttgcacg ccaagatttt tcttcgcgaa tcatctcgcc 20820 ggtttcttcg tcaagaaatt cacgagcata ccagccattt ttaggtttta ccacaaatcc 20880 taattcaaga gccatatcta acaatccaga ataaggatcg ataccaccgt caaatttaac 20940 atcaataaag aatttacttt tttctttaac ggtacgagat ttttctacat ttagaacaaa 21000 ttgatacccc tgaagatcag aaccatcttt aatctggcgc ttaccgataa tgaatacagt 21060 atcagccgaa tacattacgc ctgtaccacc tgtcatcacg gttttactaa acatttcaat 21120 tgtttcaatt gtatggttaa ccgcaacaca tggaatgttt ttaatactaa aataaggagt 21180 aacaatacgg aataatgact tcagtgattt agcacgagtc atatctgcca cagatttttc 21240 attcaaggca tcttccgttt ctttcttaga agccatatta ccaattgagt cgatgaatac 21300 aataactttt tcaccacgct caatagcttc aagctgattc accatatcaa ttttcagctg 21360 ttcaactgac tggattggtg tatgaattac tcgttccggg tcaactccca tggatcgcaa 21420 ataagctgga gtaataccaa attcgctatc atagaataga cataccgcgt caggatattt 21480 gttcaaatac gccgcaacca tagtcaaaga catatttgat ttaaagtgtt tagaaggacc 21540 tgcaaaaatg gttaaaccag actgcatacc accgtcaatc gcaccagaaa tagcgatatt 21600 aagcattggg atttttgtac ggattacatc cttttcatta aagaatttag atgtagtcag 21660 ttcagcagtc attttagaag tggaagcttt aatcaaacgg gattttaaat ctgcaataga 21720 cattcatttt ttccataggc aacattatat tttcctcact ggttaaagat agaataatta 21780 taacacaata aatttaggca ttaatcaact gctattggat gaatagcatt aaacttatga 21840 aacgcttctg atttttcttt gcgcgaaaca cacatgcgaa gaacttttaa tggctcgtct 21900 tcttcaccca acgattttct cttttcgata ttcgatgttt tccaacgagc ttgctctgga 21960 aactctctat tgatttgctc aagagctcta ttatgttttg aattactacg aattgaacta 22020 catccgcctg gagcttgtgc ttttccagat acaaccagat atttgaacaa ggccaaatgc 22080 ggataacctt gattaattaa attgagaaat gcatacatat cttcgcataa atcaattttt 22140 ccatacccaa tttgttctgt cgtaagtttt ccaaggtcat accatgtatt cgtgaatcca 22200 tatgaatttt cacgataatt accccaagat gaagtaattt taaaaattgg tagacgagca 22260 tggccatgat aatatccgca atccatggca tcctcaacat attgaatcaa ttcatagaac 22320 tgttcacgag ttaattgatt aattttatct acacagcgac gatcatcttt ctttcgcatt 22380 gaactcatac gaatagtagt atcatcgtca atcatccaaa ttcgttgacc tgcatacata 22440 tcagtaattg ctttacgagt accagcaatt ccattgacat catcaggaat agttataatt 22500 ttagctctag acccataagc gtcataataa gctttttctt cgtgtttacg tactacaata 22560 tgaggttcat aatcagatgg aaacatatca agggcagaaa ctgccccgac acgctgataa 22620 cttggaatta cgaattgaat catttaagtg ccttacattt gtcaaaatgg tatcttgtca 22680 tatttggccc acgtcctttt agtccgcaat gcggacatat tttttctatc aaattatgag 22740 gttttccttt acgattttta gacatcgttt ctttaattat tttagctttt tctacgccaa 22800 aaatttcttc ataagtttta ccagaatttt ccttggctcg atttataatt ccatatgcct 22860 gctcattttt accatacatt ggattacctt cgcctttcat tcttttagaa tgatcaggac 22920 gcttgattcc acgaaaggca tttccgcact tatatctttc ttctggagat agttttttac 22980 cgtacattcc atttaatttg cctggaaaac ttcctcccca tgcttcattc tttaaattat 23040 atgaatccgg acaattagca gcatctaaac aagttaaaat aatttcttca acctgtctaa 23100 acattggtcc ttcatataat atttctttat taaaggattt tattccatat ttctttttag 23160 catgttgcca aactacaccc gaaccatcat aattcgggtt gtgaccatca tgacttccta 23220 tataccactt tttagtttta ggatgtttat acttataaac atgtggcaca tttacttcca 23280 ttttccagta taatcctttt tagcaatatg agtctcaccg gtgttccacc aatggtcaac 23340 taaataaaac tgattttcgt acacatgaag acttccaacg ttccatataa tagaacctgc 23400 tttatattgc cgcgatgggt cgcctgcatt caaatcagat actaatttat ctagtacgta 23460 tttttgccaa gcataatcat tacgatagcc tgcccagcaa tcattgcttc tcatgctaac 23520 aaccgcattg actttcttat cacgaatcag gtactgtact gtattagtac acatgaaatc 23580 tgacatacca tctttattgt agtcaaattg catggatgga cgagtataaa tcatgatacc 23640 acgtcgagaa tcaggatttt gaccaagttc agctaaacac atatcatact gggcatagtt 23700 attttctgac caaatagccc aaccataatt cgagttaatt tcgcctttag aagatgctac 23760 ctgctgccaa atctttggtg tttcacctgg aatatcttta acaaacaagc tcttagattt 23820 ataccattca agttcgcgct gaatgtattc atcattaaga gcgccaaaaa taaacggttc 23880 atctgctata aatgatgcgc caataatttc aatagtttta acgccagttt tatcaactac 23940 gaaatctttt tcttttaatg caagccccaa atgaagacgg atttcttcaa ctgtcataga 24000 gtcactaatc atttaaacct caattgatac attcatattt aacttgtaac agtaataaac 24060 cccaccctat gataagagtt ggaatcatag caggaactgt tacgctatag tatatactta 24120 ttataaccat caagattaaa agcaacactg ctataatttt gcttttcatt ccttctctct 24180 gatgataatt acctgatttg gttgtgcaga ctttttagtt tcacccacaa ttgaccaaat 24240 aaatgtaata aaccaaccaa taattgacca gttaaacagt aaagatgtga aaaagattcc 24300 tactgtcgat tttgacccac gcatcaaggc gataaaccat ggaagcatgt atataataat 24360 agccaacaca cctgaaacta aaaccataaa aattgaacct gctactaaag tttccatgtt 24420 ttcctcactt agtcaaattt tttacacatg aattataaga attcactaca tactccatcg 24480 gagcattttt accagtacgc cattggtaat tattagccca attagcccaa atttcggcgc 24540 agtaattttc aattttttct tcgcgtgtaa ttacatccga attacgatat gcttgagcag 24600 attcatctgg acgaatagct tcgtcaaaat tcgcctgcat ttgttcgact gtttgctttg 24660 gagcttcttt ataacacttg acattaggat tataaaattt gcttgaacag tttacaattt 24720 ttcctacatc agactgattt actaccggtc cttgagctac acaaccagta agacctaatg 24780 caataaccaa aatagcgatt ttcataataa tttcctcaaa tgcaagtagt aattactcca 24840 gtagtgctta tgcaggtatt acccatttgc acacctaaag atccatttgt attcacatga 24900 agattatcat caattttaac tgatatttta ccattagtgt gaataacggt gctagattta 24960 atcacaggtt gagtatcatt ttcaacacta acaaatggaa ctgctactaa tgcaactaaa 25020 caaactgcta aacatcccat aacaattttc attttattct ccaaatctgt atcagtagtt 25080 gatagttgta tagtaccaca gaagaacagt cttgtaaaca gttttgtgaa aattttttag 25140 ggaattctaa aggtccagaa tcatctgttt ttcataagta tagatttata ttacttgtat 25200 gaaaaaggga cccggaggtc cctagattta ttctatcagc caaacaggaa gtctaacgaa 25260 gctttttctt catagtccat accagccgat tcacacatgc ctgcaagcgg tttaacaaac 25320 gatttttgga acaaagttga gtagtcaatc caagacagta catcagaacg aatttctttt 25380 ggaagttctg tacccgacgg ccaagcaatg cacttgtcac caaatggatt tccctcacgt 25440 aatggaagaa ccattacttt atttccatcc aaaattggag ctacacccag accactaaca 25500 gctcgacgat aagttagcac cccacgaata tggaacgggc atttaaatcc tggccaacct 25560 ttatcatcat atttcgctat atcgttcgca gtttttactt cagcaataac tttatagtca 25620 agttgacgat attctttctc aaagttctta taatattctt gaacagactc ttcgccttct 25680 tgaagaatac gacggatact ttcttcaaga gcttcttgga ccgctttagg cgttgaactc 25740 tgctgagttt ccatacccat gatttttaga tgcggttcag caaatcgctt atcttccata 25800 tcataaacgt tcagagcata acgctttttc gctttccaaa atccaccaac gccctttgaa 25860 ccaagtggag ggcaagaaat agcttcacgg tccatatgca tcagatgctc gcggttattc 25920 atataatcac ataactcacg atatgcaaca tcaatcatag gttccatctt tttcttaccg 25980 aactgattca tgaattcaac taaatcgttc tgctctttga atcggtcaag accaactttt 26040 tcaataactt tatctacaca aacatatacc gaatcagtat cacctgctgc gatgaaatct 26100 tcgccattag ttccacatac tttattcaga tactcattaa ttttacgagc aatccactga 26160 ataccgactt ggccgaaaat tgtgatagca gtagcatttc gcaaatcata gtagcggaaa 26220 tgaatattac caagagcacc gtaaaggctg ttaataagaa ttttacggtt cagctgattt 26280 gtattagcaa gtgtagccgc tttttcacat tcttcaatca aactattgag aacagattca 26340 gtataattcg atagttcatt taagaaatca tcactgaact taacatatcg tttaacttca 26400 ggtttagttg aacaagaccc tgcgcctttc ataataatct ttttaatagc ttcggcattc 26460 atttcttcgg cgaacatttt ctttttccag tctttacgct ggaaaaatac tttagcgatt 26520 tcctttggaa tgataccttc ttgatgctta tcatacatcc atccattcgg agaacaagaa 26580 tattcatcac tcggtttagg agctgttcct gcgatatatt catgaattgg atgaacttta 26640 aactgaccac gaatagtctc aggactaatg ttaacctgac gaataatgct aggatacaga 26700 gacgtcaagt caaaactcat aatatatcga cgagcaattg gtttaggttc aaacacaaat 26760 gcacccggaa aactttgttt aacgtgcgaa ccttgttgag gaataacctt atgttcacct 26820 ttcaatgagt taaaaataat agcatcccaa gttttaatag gactcattac accagaaaaa 26880 ggcattttag cgtaataaga catacttaaa actagatcga taaacccgcg aattttatca 26940 attgcttgaa ctgattctac gtcaatgatg ttataactga tatatcgttg atgattagtc 27000 tcacgaagtt tattaatagg accatcgtac ggtaatttac cttttttggt ttcatgctga 27060 gcaactgatt ccaaagagaa tgacggcaaa ttagtaaatg cgaatttctt atacaaatct 27120 aaataatcaa gaatagatac gccatcaata gaataaattt ctttgctacc gtacatattt 27180 tgaattagtt tagattttac tcgaccgatt ggagagaaac gtttcatact gcgttcaccg 27240 agaaccattt taacgcgatt catgatatac ggaacgtcaa atccctcaat attccaacca 27300 gtaaaaatag caggtcgttt ctgttcccaa agattgatat attccatgag catatcgcgc 27360 tcattatcga atggcatata aattactcgg tcaagaattt cttgaggaac ttcatcacca 27420 ccttcacagt caagcttagc agctaacttt gcgtcccatt ttgatactga accatacatt 27480 gaattcaaaa ggtcgaaaac ataaaaacga tcatcaattg aatcgtaatg agtgatagca 27540 tcaatttcat attcagcttt cattgggtca ggaaatttat caccagtaac ctcaatgtca 27600 cagttagcta cacgaacaaa ttttcggtca taaacaattt ctgaaccgta tgtatcactg 27660 atataagcga gtttaaaatc gttcataccg agagcttcga gaccgatgtc ttccattcgt 27720 ttcatccaat ctcgagcatc tttcattgat ggaaattttt gaggagcgca gtttttacca 27780 tagatgtctt tgtactttga ctcttcctta caatgtctaa acatagttgg aagatattct 27840 acttcacgag tacgttcctt tccgttttca tcaatataac gttcaacaat gttatttccg 27900 actgtttcga tagagatata aaattctttc atagatattc cttagtttat agcccgagtt 27960 attaggctct tgatatatta tactccaatt aagggggccg aagccccttg cttaattacc 28020 aatcgtatat ttaggaacga gtttccattc atgtttttgt ttaaaagaaa taactcggaa 28080 gttattagtt aaatctttca taaaagttct ttgaccagga acgatttcaa tcagtcccca 28140 atcttctaac agccatgcaa tcgaatcacg acgaacttca tcttcttctg tcatttcaac 28200 ttgacgacca tccatacgaa gcatttcttt aaaatgaacg atatagtata gtcctttttt 28260 ctgaagaata tgacaggact gatacagaac tttatcttta ttattagcaa ttcccatacg 28320 agtcaaagtt tcttttactt tcagaaaatc ttcaggtttt ttaagagtaa tttcaatcat 28380 tttaccattc caatgctagt tttttgagtt gtttctgttc ttttacgttc ttagtcactt 28440 ctttcaaaaa atcatccgtg actaaacctt ttagttcttt taatactaaa ggaagttttc 28500 catttttagt aagaattgat ttatagttaa ttgcatcatt tgtattaact tgataccgct 28560 tagcaagtaa cttaataatc aatacttcgg tagaatcttc gaccagtttt gcccatttac 28620 catatctttt accccgagga acagcagcca tcagataatt aaaatgggct tcatcgctta 28680 aacctgatcc aattaaattc atcgcatata cagctggcat gcattcagga aattgtgata 28740 atgcattctc aaccatgtat tttgaataat ctttttgagc aatagagcat ttagttttat 28800 tattaatagc tccaattatt tcaaaaaatt cattttcagc tttttcctta aaagaatcag 28860 cagcagattg gacagctgtc caatcttttg aataccaagc aacttgatgc tcgtttaatt 28920 gaatatcatc ttcaaataag ctcatatcac ttccactgca tttcgcatgc taattgaatg 28980 aaaagatatg ctaaatgtaa ttccgtatta gccgcaattc cgtgatactg gttattttca 29040 ccaacaattt catacatacg aataatactt tgtggagtta cgcgtgtata gatttcttcg 29100 gcaagtttac ctacgaacca cgaataatca gctgcatatt ttggtgctaa agctctgagc 29160 tgtttaacat ctttattttt gagagactca agaacatcat caatagcacc acgatcgtta 29220 gtaaccagtg ataaaatacc agcatccaaa acacctttag atgaataact atcgagctca 29280 ccaatagttt tacgaaaatc aggaaaattc tttttaacta aagctgctac aactttcata 29340 tcagctatag caattccttc atgcttacag atttcagtca atcgacgaat catctgcttc 29400 atcatttcaa ttttatcttc atcggtcggt tgaccgaacg taataactcg gcagcgtgac 29460 tgaagcggtt taataatacc atcaatattg ttagcagtaa taataatact acagtttgaa 29520 ctataagctt ccataaagga acgaagatgt cgctgagact ctgctaatcc tgaacggtca 29580 aattcatcaa taacgattac tttttgacga ccatcaaatg aagctgcgct ggcaaaatta 29640 gtcaaaggac cgcgaacgaa atcaatttta caatctgacc cattcacaaa catcatatca 29700 gcatttacat catgacacaa tgcttttgct acagttgttt tacctgttcc tggagaagga 29760 gaatgaagaa taatatgtgg aatcttacct ttacttgtaa tagatttaaa ggtttcttta 29820 tcaaaggcgg gaagaataca ttcatcgata gtagatggac gatatttctg ttcaagaatg 29880 tgttcttttt catttacggt aatcataatt tcctcattca agttttagtg taaattataa 29940 agggccgaag ccctctatta aaaatcgtgg gtagaatcag cttcaagagc tactacataa 30000 ttcgcgtgtt caccttcaaa tttagcagca ccttgtttac cttttgccca gagcagaagt 30060 ttataatttc ctggttgcat tttcatattt gccatattga taatgaaatt aaatgtattt 30120 tcaccatcat aatcaccaag agtcaaagaa tatttaacac gggtcaaagc agaatcttct 30180 actttattaa aaccgttaat tacgatttta ccttctttta ctgtgatagc aattgtatca 30240 atctgcagac cacgagatac acgcaacagt tgttgaaggt cttcagcttt aatttcagta 30300 acaacagatg ctaccgggaa tggaattggt ttattaggag caactactgt actcggatcg 30360 gctgctggcc aaaaaattgt tgaacgggca tcagcaattt taatatttcc atcttctgac 30420 tgggaaattt ctgcatcatc attaactaga gacagaatac cgagaaaacc gttcaaatcg 30480 taaattgcta catcaaaatc aataacgtca gaaatatttg cttccgcata agttgtacca 30540 ttaactgcgc gagtcataat aaattgacct gatttaagca taatgccaga gttaatagta 30600 gcgaaatttt tcaaaatatt cagtgtgtct ttagataatt tcatttcaat ttcctattta 30660 cataatagtt agaccaggac cgtacagcac cctgataaga ttcgtcgtta aacccattag 30720 ctactgcaat tttacgaaat ttattataac ttggttttcc gtaagcatgc cataaagatt 30780 ttaattcatc ttcatgttca atccaagttc ctctagcttt agattttcta aattttgatt 30840 tgaattccgg taaattattt ctaacagttg cttgaattga agctctctgt cttctttcag 30900 cattattcca taattctttt tgagatttag aaatttttga tcttacactt tctgaattca 30960 ttatatcact aaacttttta gcataactac aatcaagata tttcaatttc atcttatttg 31020 agagtttaag ctttttctca tcggtccagt gattcttcat tgaattagat attttgtatt 31080 ttacttcaga actatgtttg taacctttac gaataccgac atactcaggc gtaatttcag 31140 attgcgaaag ctttacaatt tttccagtta aaacattttt atatgttcca tatcctttag 31200 caccaattaa agtattttca tctgcgtatg ctttattaaa atattttata ttactttttg 31260 ctttaacttt taattgaaaa aatctctcca attttcttgg atctaatata gtttcagcta 31320 aaattttgac ggtatattta gtggttttaa taagttcaaa atattcatcg ctataactcg 31380 atgacacgct tccagtataa atctttccag ctgaatcaat tatatttgtt ccatcgaaaa 31440 ttgcgttaat ttttgaacct atataataac acgggaaaaa tatttttagc ttcccgctct 31500 ggaaagctaa taagatatac taaattcatt tattaaactc ggccacaatt gtttccgcaa 31560 caatttgtgc agcaacaatc agacgttcat ctgcattacc gcaataatca tcttcaaggc 31620 gttcaccaca tgaagtcata ataaatttag caccggcgtt tagggattct gcagtatgtt 31680 tgcgcattag ttcaatccat ttattactta cttcacgatc gatagcttca taatacgcat 31740 gacgagcagg tgcagattta attttgttct gaataacttc cattgcgtta tcagaaagag 31800 acaaaaccca tgcgcgacga attttatttt ggttttgcgg atttgagtca gaacgcacgt 31860 gttttggctg aatatctttt acatcaacag tataattcac agtaatttta gtcataatac 31920 acctttagtc ataataatca gtaacagtcc aagcttcatt tctattggac attatttttg 31980 tatattctgc tttaaatgca ttcctaagca tagattcagt aactatatgc tcttcattag 32040 aaaaattatt tctcagaata tatcgtttta tttcaggaaa agttaataga tgctgtccag 32100 ttgaatattc catgtttttc ctccatagag attatactct aataaattaa agcataatct 32160 cttataaatt aaaccattac agtaaatcga ccaactttct tcatttgaag atgctgaccg 32220 tattcttgcg ggtcatggtc tttatgcgaa attataaaaa cattagtgtt tttcattgaa 32280 tttataatat tagctacacc tttaatacct tcggcatcaa atgacccatc aaacacttca 32340 tcgagtatta atgtactaat actaacacca gatacaatag aagcaatatc acgccaagta 32400 aataaaagag caatatcaat tcttgctttt tcaccttcac taaatgaagc ataactaaaa 32460 tcttcgcgac cacgggattt aattgtctca ttaaattctt catctaatgt aaacacataa 32520 tccgcttcca ttattttaag ataatggtta atctgcttat taaataatgg aatgtacttt 32580 ttaataatag cacctttaat accagaatct ttgagcatat cagtcaaaat tcctcggtgg 32640 tatttttcca ttactaaatt agtttttgtc ttaacaattt tatcaagttc ttcttgaagc 32700 agtgctattt catcagcatg gtcaataaac tcagaagatg ctttttctat agccgcttta 32760 acctttttag ctttatctac tgtcgtgatt agagattgct ttttattgcg aatatcattt 32820 gccaacgact gttgggtttt aatattatct cggtattcat caacaagaac ttttaaatta 32880 tcacgatgcg ttgaaagctg ctcaaacgaa tgcgtgcatt cagaaacttt atctttaatt 32940 ttagaaacaa ctttatcacc ggaactcaat tgtgacaaac aggttggaca taatccacct 33000 tcgtgataca tattaatgac tttattatac gagtcaattt tcgatttaat taaaaatgct 33060 tcttggccga ttttattaaa tgcatcagtc gggtcttcat ccaaaacaat attaactaat 33120 ctttcattag cttcttctat ttccgatttt agcgttctag cttcttttgc taaatcatca 33180 tacatatttt gcagacgagt aaggttgtca cccgttaatt ttttctggcg ttcaacgtta 33240 tcattatata ttttaatttg ttggataata ttatcttttt taacatcaag cacctggttc 33300 tgcgaattta attcacgtat tagtgcttta ttaagcttat ccatttcagc taatgttcct 33360 acctcaagca ggtcttccac aagctttctt cgcgcagggg tcgacaaacc catgaaaggg 33420 gtataccctg ctgtaccaag gacaacaatc tgcttgaaac tggcatatga cattccgata 33480 agctgttcaa attctgcttg gaaatcttta ctgctggcag attcattaag acgtgtaccg 33540 ttaacggtga tttcgaaaac gtttggtttt tgtcctcttt tgatatagta ctttttctca 33600 tcatattcca tccacagttc aactaaaagt tctttcttat ttgtgctgtt tattaattga 33660 cctttcttta catcacgaaa tggcttgcca aaaagcccaa atgtgatggc ttctagcata 33720 gtagacttac caccgccatt tcgtccagta ataagagttt tttgaacctt atctaattga 33780 atgtcaactc cattttgacc aactgacatt atatttttat attttactct attaagttta 33840 aatgatttca ttttgtatcc aattgttcac aatgaagaaa attctttaac taaagcctgt 33900 aatgaagcct ctattggata tccattctta actaacattt tcctaaacat tacatgttta 33960 ggacgattat atgatatcca caattcatac aatttatctt tattatccca atgatagcct 34020 tttcgtcgag atgctatatg agcttttcta atctccggat ttttccaact agcagctact 34080 gaatttgata tagctatttt atattcaggt tttgataaag cagcacgaac agccttttgg 34140 tgtttaattt tattttcttc gttattaaac cattcccttg aagccattga aattttttgt 34200 tttgttttaa aattatttaa tctttcttta ttatctttcc tattttttgc tactgaaaaa 34260 tattttaatg ccctttctct agcagcattt ctattttgcg gatttgaata atactgttga 34320 agcctttttg atattgtgtc acttacatct tgttttataa aactatattc agcagctatt 34380 aaatcaactt cggctaaaga taaattttta tatgtttttc ctgacatcat tctatttaaa 34440 gcatttaaca tttttccatt tttacctttt gctaataaga agtgtgcttt aaaatgatta 34500 aaatgactta aattaactaa attccatgta gattttaaat attcaggaaa tattgattta 34560 ggaagcacgt ggtgtgcttc cgttttacct ggagttttaa cagttgaatt cacagaaata 34620 aaattaatgt aagacttggc gtcttcttca ctcaacgcta atttttcaac taattccttt 34680 attaaaaatt catcattaat gtcaagttta aaattcttca caaaagattc cttttaatgt 34740 atcttttaga ccattctatc atatcatcat aatctaaaaa gtattcatca aattcagcca 34800 tgcaaacaac accttgtgct gcttttgatg tgatataaat tattccaaca tatctagaat 34860 cttcttcggt ataatcaata tttgctatga attcatcgtt aatgtcaaat gtcgaaaact 34920 tcacaatatg catccttaat acaagataca gccatatctt gtaatgattt aggtgtgtca 34980 ttatctaaaa tgttgaagtt aaaagataca gcccagtcag tgcagaccgt aaccttttta 35040 atacaattat cttcaacctc tagcggttca aaccaatatt caataatttc tttatgccca 35100 atatcatctt ttacttcgca ttcaaaatgc tgactcatca taacattttt aaattcatca 35160 aaagtcattg tgttgcctct acatatagct gattcgcata ttgaataagt gcttcacggt 35220 cagaatcagt gatgtctgga attgcattaa tgtattcttc catcaacgtc tgaagagatt 35280 gaacttcaac ttcttcactg tcatctgact cgacagagtt atcaatcttt gacacaactc 35340 gtaacgaatg cacaactttt tctagttcag attcgaactt cgtcagattt ttgtctactt 35400 cagttactat aacacgtact gatagatttg taaaatcttt atagtcaatt tttcccttaa 35460 atggatattg aattcgacga tgccaggtag tgttgtttgg aataaattcc attcgttctg 35520 tttctgtgtc aaacatccag aacccacgag ggtcattctc gtcacctgca gttagtgtcc 35580 atggtgtccc aatatatctg acgtttgcag cctcagaaat agtatggaag tgaccagacc 35640 acacttcttt ataagtctta aggaaatcag gttcaagacc gtgagatttc attcctttat 35700 aaaaataaaa tccattcagt tcccagtgac caacacaaaa agaagcagat gaagttttga 35760 tgtgttcaag aatttcacca gtattttctt cgcacatcca aggaattaaa tcaatcaaac 35820 acccgtcaaa atctactgtt gtaggcttat catatacttt aacattagga tatttagcca 35880 aaagctcagt agaggcattt ggatgcatta catttttgta gtggagatcg tgatttccta 35940 caatagtatg tagggtaata ccagcaccat caagcatttg aactatttca cgggcaaact 36000 ccatagtttt atgcgtgatc gcttttcgca catcaaaaat atcaccgtat tgaatccata 36060 ccgtaattcc atttttctta gaatattcta tcgcttgctt aattccatca atttgaatac 36120 cgcgaatcca ctcatcatca gctttaacgc ctaaatgcca atcacctaaa tttaaaattt 36180 tcatatatca agaaccgtca ttgaaatgca aaataaaatt attgaaataa atccatctgg 36240 agtgctaaag aacccaatcc aacatgctct agtgaataga taaaatgcaa gaaaaagtat 36300 cacatatcca agaaatatca ttatatcaaa ctccgtataa agctaaaggg ccgaagccct 36360 ttattttgta ataatgtcaa actgttcttt aaagcagaag cttgaatctt gatgctgata 36420 caaaaattca taagcttttt cacgttcgcg gtcataaaga gttcggtcag atgacagttc 36480 tttaatacgt tcaaatgttg attccatgtc attttcatca aaccaaacga taccgctatc 36540 atgagaaatt aatggagtat tatcaacacg gaattttaaa ttttcgcctg tagatttcca 36600 aaataccgga attgttccac atgcaccaag ctcgagatga gtatattcta aagaacgttg 36660 tagatatttt ttatccaact tactcaactg ataaccaaat ccggatttac tcatgcgttc 36720 aagcatttcg ctatttacat aacggtcaag aatttgcgtt ggcaaattag gagcaatttt 36780 aatttggtct acttgatgaa gacgataata ctcgtatgga attccttttt ctttaatagg 36840 aatgaacgct ggagaacgtt ccagaccttc cataatagta cttagtcctg caggtttaag 36900 atgtttttca tgaaaatcaa acatctgata aaaacctttc catgtagtcg tacgaccaat 36960 ccaacggtta acattcatgt taacttcaga aacatctttc cagtaggttg accgaacctt 37020 cgcaatatcc ataggaggct gaaagttata tacggtcggt gcttcttcaa tatcatcaaa 37080 cagagaaact gtttctggat accattcttt catcaaaact ttattaaaat cgccattatc 37140 agaatgacta aaaataacat cagctcgacg aacagtttct tctaatccca aatttcggcg 37200 caaagaaaga gaagaatggt catgttgata aactacaaca cgaaccgaag gcttaatgtt 37260 atcaataatt tttttatagt tattaatagt gtcttcttcg accgaagtag caggaactga 37320 attgataatt agaatatcac aatcatttac cagcttaagt gttttatcgt attcttttgc 37380 caataaaacc ggaattgaaa atgatttata atcatgcgca caattacgag taaatgattt 37440 atctttagca taaaccaaag ttacttcatg accattttta ataaaccaat cacgttgctc 37500 aagagaaaat ttagttacac cacaaccttc aagacctcga gccataaaaa tacatacttt 37560 catttaatat cctcattgtt ttggtttatt ttaccaaaaa tttataaagc aatataggag 37620 ccgaagctcc tatccgcata atacaccata cagaggctca ttagagcttc taaattttat 37680 acgcttatat gttatagttc cttctgcttt agctttatca tgagactctt taaagcgtct 37740 catcatttct gctttagagg aacgaatttt attataatct atttcagaag tctgggtgtt 37800 catctttcac agttgccacc attttttgac ttgataggaa tcaacccaca ctttcatatt 37860 agggtctgct cttacaatag gaggattaac ttctttaatt gaactatcat ggtattcttt 37920 ttcagaaatt ttcacacaaa gatgaccgtt caaagattca gtaaatcctg cattaatttt 37980 aagacgcttg aattttacgt ttgtaagcat caatcatatc ctcaatctgc gatctagtag 38040 tcttccaaag aatactaatg agttcatcgt tatatggctg ttttagaata tcccgacttt 38100 tcttgatagc atattcgtat tgagcaaaat tattgttttc agctgcaatc tgagcgtgct 38160 tataaagacg gttcagttcg cgtttgtttt tagacaataa cttatttgct tttctttctg 38220 cttcaagacg gttcttttct tcaatagaag aaataagctt ttccacttca gcattaattt 38280 cgggtttatc agtcatatta tttctctaat ataaaataaa aatcatcatc tgttaaatga 38340 taccgatagt ttaattctac accattagat ttaaaagcgg tatcatacgg attttctgga 38400 tcaatatcaa tgtcaagagc taaaacttcc ctgagataca ttttaagtaa atagggaata 38460 gcttcaactt caggtatttc ttccaggaat ccggagaggt taatcgttag cctcatataa 38520 aaaatccaaa ctaggagaat cgtctacaac acttttcttt tcagcccccg gtgttctata 38580 ggttgattct tcgtaatgcg tcattttatc gtagatgtct tgaataaaag tttcatctac 38640 taacgcaacc atatcgtcgt cacgactgtc atagacattg tgaacgaagt aactgtattt 38700 ctttgcaact tccttacgtt cttttttaat acgttggacg aatgcattaa aacaagcttg 38760 agttatatat gcatgtgggt ttttatattt cgtttcatca aaattatgaa gccccttaat 38820 agaagcttct ataccatctg caatcatttc ttgtttccag gattgggtgt atcctgaaaa 38880 gttgaaacgt ttagataagc cttctgcaat aagcataatg gctaatccga tagtatcatt 38940 ctgacgaact actttatttg gatctttatt atttgctaat tctgttttcc aatcaataat 39000 agcttgtaaa agctctttat tgtttacgta attatattta ggcttagttt ctgacatttt 39060 cacctcttag ctcaattcat agatctatta tatcataata tttgaagatc tatcttaaag 39120 catagaggat atcagttatc taagtaagca gtatgcttgg aacactttct ccatcatctt 39180 tttaaattca tgaatatcta tgtaatgact agttaaatca gcgtgatata aaaagtctaa 39240 aaacttttca tgcgtgctaa catattcact ttcatttaat tcagaaacat ggctttccca 39300 atatccaaca ccagtcttat ttgggaaaaa tgaaattttc atgtattgat caacatagaa 39360 aatgccataa ttttcaatag taatagaaat attaataaat ttcatacatt catcaactta 39420 gccgcttcaa gagctgcatc tagtgaatca aattggtcaa catattcaat caattcgccg 39480 taattagcat ataaccacca ttggctaaat tcatactcaa ggatgaatcc gtttccttca 39540 atttgagtta aaccaatgcc atttgtattt acttcatatc cagcaagacg caaatcgtta 39600 ataagagctt cgttcataat tataccttag taattttcag gtctgcaaat tttttcttgc 39660 gttgattttt catgcgacga atagttttat cggaaatttc atgcttttga taagctttag 39720 attctacacc aaaagcttta acatcaaatt ctgacaagat atattgaacc aacaattcac 39780 ggacagtgtt gcgtccaatc ttctgatcat tctgtttcat cgtctgatga agttcttttt 39840 cccatttatc caaaatttga ggagttacaa tatcgccttt ttctagcaaa gaaactactt 39900 tatcatatgc gtaagaattg atggcgtttt taatttgaat agtcatacat tatcctcaat 39960 tgcgttaaaa ttttattatc caaaaaaggg ccgaagccct tagctaaact gtttggcacc 40020 cttccagcct tcgtacatca ttgcggctga tattaatatt gctcctgagc aacttgaata 40080 tttgtgattc caaaaccagt ttagaaaaac ttcgtcatca ataccttgag ctatcatatt 40140 ttcaaagaac tgacgacgag cttcagcaat tcgttgcgat aatttagatt caggattcat 40200 ttaaattttc cagttaccat tttcatcaat aaatttaatc cagtcattta ctgaccactt 40260 ggtcgtatcg ccctttggag caacatttaa agtgtataat ccttgtttaa aaagcattcg 40320 tttgatattc atattttcct cagctgtaac gatagcactc gtttgattta cgcttagcaa 40380 ctcgttgaga agtattataa tcaaaatcat catcaatgta aactgatttt ttcaactttc 40440 ttacttcacc acgtaattgg cgatttagct catctttaac ttctgaatca atgcctttca 40500 ttctacgcca tttatcagag cgaaaaatgt tttcgacaat atctttatga cttacaccat 40560 caggagcttt acgctttccg aaatagtcat aatcacgaac tttcaagtct ttacgacgat 40620 acgttttacc catggagttt aatttcctta gcaactgaac taaatacagc acggtcacaa 40680 atcatctgtt tatgtaactt gagtataaga taataaactt caaaaccgtt tacataagta 40740 acacgaacaa cattaccatt aataaaataa tattgtccct tttttaattt ctttatcaac 40800 cacaaccata tcaaatcctc aaaggcaatt catgtgttaa taataccaca gtttgaactt 40860 cttgtaaaca actttgtgaa aattatttta gggaatgata agaagggaac gataatatac 40920 agaatgtgag aaagaaaggc ccagagggcc cgtcttagtc ttctatgata tctctatcat 40980 atccaagtga aatgagagtt tctttgaagt gtttaatgtt cttttgtcta gaatcattaa 41040 tgaaaatgac tggataacga atgttaagag atgtaaatcc agcgcgttta gcaagagata 41100 caatcagtgg acgatcatac tcgatcttac cattatttgt aagaacttta tagaaagtaa 41160 aaggagcatt gagctccttt agaagttttg taactgattg acatccagga caacgaccaa 41220 cttcatctgg aattccatag acttcaatct tattctttaa gttcgagttt tgttccacga 41280 gaaataattc cttgataagc ccaatatggc gggttaacag aatcatcgcc agaattttct 41340 tcaggaaaat aaacctggat aacaaatcca gattcatcaa aggtaaaata aaccgtaggt 41400 aattcaccta acaattcagc acgattatta atttcttcga gttctcgttc acgtccggcc 41460 caaaaactag gatttagact acattcatag aaataatagt cattaccgaa catatcaaaa 41520 ccattccaac tctctaccac ataccgctca aaactaatca taattaagcc tttttatcaa 41580 gaacagcatt cagtttgcta gtaattttat ccagacgctc attgaactcg ctagaagaca 41640 gtcctttttc tggagaaatc aaactaatca cgaaaaatat agcaataaaa ggaataagga 41700 aaatagctcc aactgccata aacagaaaga atgttacagt tgtaagaaaa tcagctaaac 41760 ctttacgaaa tttatacata ttttaccctt aattgattaa ccaagcattg ataagcacta 41820 aactatactg tgaataaaat tctggaccaa aatgaaaaat catatcattt atagtatcca 41880 taatataatt caatttaatc atgtttccac accccatcgg tatttgacca aagtcgctga 41940 ttatctgatc ctcgccacag ctttttagtc ggaagatttt tctcatactt cccatcaata 42000 ataacatcaa catatttaag catttctagt tgtttaatat cttcaaactt atatcctgtc 42060 cacaaccaaa tgcttttatt tggataaaga ttttttactg tttgaacaat gcaatgaaca 42120 gcatctcggt tatcaggata gagagggtct cctccagtta tagttaatcc ttctatataa 42180 tcgttattca aacattcaat taattgttcc agcgtttcac cagtgaatgg aacaccattt 42240 ctagcattcc atgttgattt attataacac ccttcgcatt tatgcaaaca acctgtaacg 42300 aaaagaacga ccctgcaacc agggccattc acaaagcagc acgggtatat tctgtcataa 42360 ttcataataa tatccaattt ttccaagctt catcagtaga attacagcgt tttagtataa 42420 gatgtctaga aacttttatg gcatttgagc actttttaat tgaatcatat ttaataccgt 42480 caactgaaac ggttttgcta gttggagaaa tttttccata cattggattt tttgaaccaa 42540 cttgaagtcc ttttaaagct tttgaaagct tttgtctaga ttccaatgac atgggagaat 42600 tctttttacc ttcaataatt cgcttgcgat gaagttcgcg ttcttcttca ctcaaagaat 42660 tgtaatattt tttaacaccg tttgatatag ataatttatc tttctcagac cgctctccag 42720 ctaatttact tctaacatct tttcgcttca tagctatgct tacggcttta tttaaatttg 42780 cttgatgctc tggcgtacgt ttatatttct ttaaagcacg tgaaatagct attttagttt 42840 cttctgttct ctttttacct ttatttgcta aactattttt gcggcgatgt tcaagtgtct 42900 gttcataggc agttccacct tttccaccag gtttaatatt atatgtattt tcttttagac 42960 aatactcttc ggttacaagt tcagcttctt tatcatacat ttgtttttca ttatcaaaaa 43020 catgtaaaat ttctttatta aaattttttc taccatattt taataaagcg gcacgaatca 43080 atgttcctga ccccatataa ccgtcattta tgttatcggt gctatgcgca ccgatatatt 43140 cctttgaatt aattatattt gttattttat aaattatata atacctatgc atgttttact 43200 cgttttacca tttctttcat tttacctaaa ttccatggaa caacgctagg agttccaaga 43260 tatccgcatg ttcttcttat tgtgttcatc tttttaggat cagtttctcc acaaatagaa 43320 caaacaaacc cgttttcagt aggagtcatt tcatgggtac ttccgcatgt aaaacactta 43380 tctactggca tgttaacacc aaaataatct aaatgttgtg cagcataatc ccacacggcc 43440 tcaagacctt ttaagttatt tttcatatca ggaagttcaa cataagaaat gtgaccacct 43500 gtcgcaatga aatgatatgg cgcttcacga gaaatctttt caaacggagt aacattttct 43560 tctactgaaa cgtggaaact gttagtgtac cagcctttat cagtaacatc ctttacactt 43620 ccatattttt ctgtatcaag tttacagaag cgatagcaaa ggttttcagc aggagtagaa 43680 tacaagctaa aagcaaaacc agttctttca gtccactgtt taagatgagc attcatttta 43740 gttaaaattt cttgtccaat atcacgaccg acaagaatat tcaattcgtg aataccaatg 43800 tatcccaaag acactgaact tctaccgttt ttaaataact caattatgtc gtcatcaggt 43860 ttaagacgaa ccccaaatgc accttcttgg taaagaatag gagcaacagt agctttaact 43920 ccttttaagg aactaattct acacatcaaa gcttcaaaac acaaatccat tcgctcattg 43980 aataattcag taaatttctg ttcattgaat tgtgttccaa tataagaatc taacgcaata 44040 cgaggaagat tcagtgttac aacaccaaga ttattacgtc catcaagaat ttcattacca 44100 gtcgaatctt tccatacgct caagaaacta cggcaaccca ttggagaaac aggaacagat 44160 gaaccagtga tagctttatt gttcttagct gaaataatat caggatacat ccttttgctt 44220 gcacactcta aagcaagctg cttaatatca tagttcggat cgtctttata aagattaaca 44280 ccttcttcaa cgaacataac aagtttaggg aaaataggag ttatcccatc acgaccaaga 44340 cctttaatac gatttttcag aattgctttc tgaatcattc gttcagtcca gtcagttccc 44400 gtaccaaatg taattgttac aaagggtgtt tgtccgtttg aactaaagag agtatttact 44460 tcatattcat aagcttggaa tgcatcgtat acatcttttt ctgttttaga ttgagcataa 44520 ttcaatgcat cagcgatttg ccatttttct gcatcctcaa tatgttttgc ataggtgcgt 44580 ttaacataag gagaaagtac tttatctaca ttagcaaaag tcgttccgcc gtattggtgg 44640 gaagcaacct gtgcagtaat ttgtgccata attgcagtag caacgccaat tgatttagga 44700 gtttcaatct gcgcattacc tagcttaaat ccgttctcaa gcattccttt taaatctact 44760 aaacaacaat tagtaaatgg aagagcaggg gaataatcaa tatcatggaa atgaataatt 44820 ccgctttcat gcgctttcat aataaaagac gggaccatat ttttggcaat gtgtttagac 44880 acaataccag ccataaggtc ccgttgagtt ggaaaaacac gagaatcttt attagcattc 44940 tcgttcaaaa ggtctttatt agttttatga atcaatcctt caatttcttt ttcaattgtc 45000 attttaaact ctttctaagc tgcttcttga atgaagctat taattgtgtt ttggtgtcag 45060 attcattata ttcaaatcct ctttgaagca tctcggccat catttcctct tttcctaaac 45120 gagaaaattc ctttgattta tctccaacga agttagggtg aatattattt tgggtgtaat 45180 cggattttaa ataagtaagt aaattttcta accattcaag ataatcaaca ccttgtccct 45240 ttaagccaga acgattaaat ttatgcttca tttgaccttc tgcggcattg cagagattac 45300 aaagcaatcc acgtaccttt cctgcttttg gtccatttaa ttcatggtca tggtcgaggt 45360 gattagcttg aacgtcagga tttagttctc gttggcaaat taagcattta ccattttgtg 45420 catcataaaa tttctgtttt tcttctttgt ataatttgcc agtcaataac ataataaaac 45480 ccttacctta aatagataag ggtatttatt atttttcaag tattgtaaaa catttgatgc 45540 aatcgcttat attgctgaat cattcggtca gaaaaagaaa tttgagtttc aagccattca 45600 atgtattctg cggcagcttg catcaggtta ccttcatagc catcgttatt ttcttgcgca 45660 gctaatttag ctaatgcgta tgaaatacgt tcaccttgaa aatcggcttt aggcttctga 45720 acaacttgat tagttcgctc tacaacttct tcaatttcgc cattttcgac tgattcagta 45780 ttccataagc accaatacgt aattgactta tcatagatat taataatctt tccgtcggaa 45840 agttcaattt caataattcc agtatcaggc tctatatcat cttcacattc ttttgcaagt 45900 tcacgaactt taaagacagt acctgcacta agttccggcc agtaattaca cagccctgta 45960 tcagcacgat taattctaaa ccacttatct actgtaatca tgtcccatct ccatatcaat 46020 taagtcattt atcgttggtt cattatatat tgtttcttca tcagtgtaaa ccggttcttc 46080 cggctctggc tctacagttt cccatctagc cgcccaccaa ggttttatag cgtaatccat 46140 tctcgtactg tctgagttac tacacgttca tggggctcga ctagttcaac agtcggaact 46200 gcataatacc agtcagaatg ataagaacct gaccgagatt catttaccgc tacatgtacg 46260 ttatgttttg gactaaaata aacacactga cgatattgac atttgccgtc ttgtacccag 46320 tcttctattt cgacaggttt aagataatcg gaaaaatcga aatcatagtt ttccgaaaat 46380 gcatcatggt cttcaatgat ttcgctcaga actgcatcaa catctaattt attttcaata 46440 gtcatttttc accaattaat ttcgcaattt attaagttct tcatcatcaa tccaggattc 46500 tagtcctgat ggcagggcac attcaatttc ccaaagaagt tcttcaattt tctgaagacg 46560 ttctagttct tcggctggaa tagcaaccat tgacggagct cgtgatacat taatatcgta 46620 aatcatattt accccaattt aaccacacaa tcgccgtatt tccacttaga aatagacttt 46680 tcaccattag aataataaac ttcgagttta gcacgattat ttttaatttg aataaccttt 46740 gctgtcatca aagttccata cccataataa actgcaactt catcacctac atataccgcg 46800 cttccgcggt aatcatggat ataatcagtt ccttcgagaa tcatttaaag tattcccgca 46860 attggtcaaa tccaccaata tgacttccat caggagcaaa tacctgaggc atcgtcaaac 46920 caatttgagt atcacgacct agtttcgtta gaagctcagc gattttctca tcatcaaaaa 46980 cacctttttc cggcataatg ttgataaatt caaacggctg tttcttcaca gtcaagagac 47040 gttttgcatt atcgcaatac acacatttat ggatgttgct atcataacca tatactttaa 47100 acatattatt ccttaattcc tagtacttgt ttaaaagtct cgtcgtaatc aagactttga 47160 cctgtttgtt ctttatgttt gtatataata tcacttactt ctgatagcat atttttatat 47220 gaacgagtta aagcagattt aagcacgctg tatctatcag gaaatttacc atgttcatta 47280 taataagcta ttgctaattc acggactgcc ttttcagcaa tctccatata ttctttacgc 47340 tttgtcattt taatccaaaa tattattagg cattggttga acactcgcaa gttctttaaa 47400 gaactcagta gagtcaggta atttaaccat ttccggagca tgcttactaa atttatgttt 47460 gcaatgacgg catttatatt caagttccgg tttacgccag ttaatcaatt gaacttgttc 47520 agtaccgcat tcaggacaat taggaacgtt tttagaagcc ctttcgcgac gttcaaccat 47580 aaccataata gcatcccagg ctggaggttt aaaatctaaa tcatcacaac catgaatctt 47640 tccgcgcatt tccagatcgt cttcttcacc agccataata attttaatta gactggaatt 47700 acttgaagct gcaatatctt ctaatagacg ctttttcatt tcaatacctc aatagcatta 47760 cgtaaaccat ttgcttttgc attaagagct tttaacaatt tagtgtgttc ggcaatctga 47820 gcttcaactt caaccagtcg agatttgaga tattcacgtt cttcactcat gttatcaatc 47880 ttttctactt taggctcttt tacaactgtc ttatatgtat taggattctt cagtttaatt 47940 agaatacgtg aactgtataa cattgaacca ttatcttcga tttcgtcata catttctact 48000 acgtccataa tttttaacat catgcgaagt ttataagaca acgaacgaat agttttgttg 48060 tgcttattaa tttctctagc tgtcatggtg ccgagattac gtgagtaata ataaggaacc 48120 tggatattaa ttaatactga tgaaccacct ggcttgtgtg ttacttcatc agcaataacc 48180 cagtccttaa catgaactgt atttgtacgg tcatcgcctg cggtaaatag tttgcgagca 48240 tgcttaaaaa gcatattcac ttgggtattg aattgacaag caaatttatc agcaaattta 48300 gtttcaggaa tggtagataa ccaatcagct aaatgggtct ttttaacatc gttaacaata 48360 gtaaattcaa ccaaatcgat tatagatgtc gcagatttaa tgaagcttgg cttcataaag 48420 tttttaatgt tatcgcgagc tacagtagaa gataacatac gagaacgttt aaaccattca 48480 agcaaattgc ctaacgaatg agaataagcg ttttgagtat ctttacagat atgattttcc 48540 tggccaacat attgaaggaa atcacgaaga atattattaa ttactgatct gtgtccgatc 48600 tgataattgc ggtgtttagt aataagactg tcaaaataat caatataatg tttacgagtc 48660 atattaatct cctcagtaga aagtaagaac attataccac atccttgtgg cgaagtaaac 48720 tagtttagtg catttagtgc attgttcagt ttagaacgtt gcttcgtgag atttttgact 48780 ttttcttgag ctttttctag catcttttca gcttctaaca cttcattagt tgctttaacg 48840 agttcatcat ctactgcctt aagggacttc tcaatcgcat ccgcgtgcca tttttcaaca 48900 ggtttaagac tcggattttc aacaggaaga aaattcgctt tattgaattt ccatgcatcc 48960 ttattacctg aactatacat ccaaaattta ggatcgtttg atgagtaatt ggataaattt 49020 aagatatctt gcacttcctg ctttttctct tgcgggattt cgtcctttct caaaaaatcg 49080 tatttaaatg aaacgatcat atcaagttca tatattgttg tgtctaattt aaatcgctca 49140 aaacgaggta aaatcttaga ctgaacagcg gcaacaacat ccatatactt aaatgcttct 49200 gccaactgcg atttaaggca ttcgcaaatt gaaagagaat tttttgtatt aggtttaaag 49260 ctaattcgtg cagttctgtt attttctttt aatggtctta cttccatctg aagagtataa 49320 ccatcaaatt tcaggttctt taagttaatg tcagaacctt ttaatcgact agccgtcgac 49380 aaaatttgct ttaattgttt acggaataga gcaataaatc tccattcaat acgataatga 49440 tttggattaa aaaatccaga tgataaatcg accttactct gaccaacgcc ttgaacaaat 49500 agaggatttt tataatcaat agttttacag aaatcggtga gctgctcacg agccgtcatt 49560 tgtgtaatat accccgcttt actaaaatga cgtaaccatt cactgctatt catatattta 49620 aagtgaatat cacgattaac tttatcaggg tctaaattat tttggcacaa aaatgtcata 49680 acatcacgag tatagctggc attacgaacc atatcttcaa tttgagaacg agttttcatg 49740 gtgttcctta agatttaagt aaatcgacaa ttttaattaa cttttcacgc tcagatttag 49800 ctttactact cagtccagat agtctgaaaa tttcatcatc atattgttga atagaaatat 49860 tcagctcttc aatctgttta ttaaaataat caatttgttc agaatgtttt tcgttactac 49920 gaactggtac aggtttcgta ggcaatttag ttaaactgga ttcatccggg cgataaatta 49980 aaatacaact tgaaccaatc gggcattttg caccagatga atattctaat gttccagctt 50040 cttttaaaac ttcaaaagct aaacagagat gatgccccat attaacataa tctgtagagc 50100 gagctctgat gtaataatca tctccgcgaa tactaaattt aaagcattta aggtcttctg 50160 tattattggt cttaaaaatc atttgtttat ctagaccttt agctaatcga gcgcctaatg 50220 ctaataatcg tcgttgattt ttccacaaat ccgcaatcat ttgatcgaat gataattttg 50280 gcattagtcg accataaagg tcatatcctt tattataatt acgaaggatt tcactcgcat 50340 taatgcgaga caacgctcca attttattaa gggctttcat gatacgatta gataaactca 50400 ttccagaccc gtttgttcgc tgtagatgtt tttctaatcc aaatccaata tcaactttaa 50460 acttatctaa aatttctgca tgaacatctt tgtcgataac attcaaatcc aaagttgggt 50520 taaatctatg aaaaaattta tctggctctc cacggcgaag tacagtccat tcattcaatt 50580 ttttattaac taaagattta attactgcat tgacattatt aattactact gacatatttt 50640 cctcactcat tttcaatttt actaaataca cagaatatga ttgaacagac tacataagca 50700 ccacacacag attgaactaa taccattcca aagaaccaga caatattatc aaaccatgtc 50760 tgttttacgt cgaaaggacg taaacttaca gtaatattat cacctttttc tattgaagaa 50820 tacatctctg gggaaatata ttcactaaat ctataaccgt ctttgagttc atatacagca 50880 ataaacgata aactagaccc ctttccttga gttcctgtaa gggtattaac tacagtaaca 50940 tcataatctt tataatgcat ataatcatta atagcataat aaccatatgc aattgctata 51000 cataaacaac atatcaataa attcaatctt ttaattatca actgtttcat aataatctca 51060 attaaaaggg cttagaacca ttataccatc cttggtataa agcggttatg cgagtaccgt 51120 ctttaaccgt tcttcaaact tccgaagagt attttggcgt tcagctcttt gctttttgta 51180 agtttcaata cgctctgaaa tgagagtgta tcgttcattt actgattctt tcataaaatc 51240 aggaatttca cgagaagctt taatctcgtc aaatttatca ataacagctt gctcttcagc 51300 aattaagtta tcatacatta aaatatcttt cttgatgaac tcaatatctt cttgagttac 51360 acgagataat ttagatgctt tatccttttt gtactgttcg ttagtatcac gagaccagtg 51420 taatgtacga tttttattcg tatttttgta aatttctaca ataccgatct catcaataat 51480 aacgatccaa ttccaacgcg atttgtaaat ttgtcctcca tcaacagtga tttcacctcc 51540 gattgagatg tcattaaaga acttgctttg tgcttctgat ttaaatttac catcgttgta 51600 atttaccagg ttgaaaatat ctttagcgtt cattttgtgt tcctccgtag ttgatagggt 51660 aataatacca cagaggaaca gtcttgtaaa ccactaaaag aaacttcttt cacaattttt 51720 tccactgaac catgcgctca ctgctttctt agtctcagga gcagtgttat ccataaacca 51780 ttcaaaggca gcctttttat gattctggag ggcttctcgg gctttaatct gctcacggtc 51840 tattaacact aacatatgag cctttcttgt caccatgggc ttcttatgat tttttgaata 51900 ctcccaatca tttgtccatc gcattgttgt tgcgaactga aatactgctt ctttaatttt 51960 agtttcgtaa atttcacgag cctttgagta taacatcact acctccattc accagtttaa 52020 ttctagtcat ctttttaatg gcagtccata taatctattt ctgaactgcc tttttgtcat 52080 agaagtcctc ttatgaatta tttcagaaga gtaacctcag cgatttcttc ccaaccgttt 52140 ttgtcggtca taataaagtc agcaagataa agagcagtac gcagtgaaac attgcgtaaa 52200 cgattaacat tgactttcat ccatgataat gctttataag tttcttcatc agaaagaccg 52260 cgcttttgca tcatgtcagt tgaaagaata acatcttcaa ccctgaccat aatttcttca 52320 ttagtgtgaa cacccaaatc caaataaact gagcgggaca ctaatgcttg taaatgtgga 52380 gcaagtttag taccacggtc taattcgcgg tcaatatcaa cgtttgtgat aaaaacaata 52440 gttcctttaa attcaaactc gcgctcaatg cctttttctt ctaagtaaga agatgcagtg 52500 ctccagcaga ctttacgggt ctctccagtg tccagagcag cttttagaag attaagaatg 52560 tccatatcag agaaaacatc cacatcatca atcaaaagga cagaattctc ttcacgatta 52620 ttccaaagct gttcataaag accaatacca gagattttac cattaatgct tttatactca 52680 atgtatccaa tatcatttgc tttatttaaa gctttatcta aagaatacgt tttaccaata 52740 cctgctgctc ccgagataat taatgaacga atgtttccgt taataatacc attcgtcatc 52800 attcccataa cattaaatct tttattaatg cgggttttca tatcttcata cgattcttta 52860 acttcttcaa cttttacacc atcatatgaa atgtctgatt tgtaaaccca aacaccgcga 52920 cgcttaccgt caatttcaac aaaaacttta ccatctcctt gtgcatctac cggagcatta 52980 tctgggaacc attcgcctaa gagttcaaaa gttccagaga tttctttacc gaagtagata 53040 ccctcttatt gatagttaca gttttcattt tattctccaa atctatatca gttgatagtt 53100 gtatagtacc ataaagcttt atgcttgtaa acagttttgt gaaaaatttt tgaaataaaa 53160 aagggagccc gaaggctccc tatcatttat aataacttct gtggttttca agatagacct 53220 tctcaaggaa gtcatcccag aaactcatgt ctactgtttt aggcataccg ttcttagaag 53280 cttcagtaga tgctgcttct acttgatcga ccacatcttc taaaaactct tgaaccgttt 53340 taaatggatg cttacccaac ttcacgtcga gaataaatgg agcgtcttga agtggataaa 53400 tcaagtcgcc agttttgtaa atttccaata gttggagtcc accacgacaa gcatgactta 53460 gtgctttcca atcaatacct tcattagctt cggctttacg agcacgttca ccatattcag 53520 catctaattt gttcagtgac tgcttaagct caataagaga aagcgttgtc tgatatttac 53580 gacccagcac tgtatagaac gtttgtggac ctgttttctc atgattatgg aacacccatt 53640 cacagaattc gttctctgga agacgatgct taatatcttc aattttagtg cgacgttgtc 53700 cttgtgttcc atcttctcgg taaacattcc gttgatcagg aatttgatta actactttca 53760 atacatcacg taatgcagcc aaacgagaac ctttaacacc atatttagag gcttgtttac 53820 gaacatatcc taaataggat ttcatgttag tcgtataaaa acgagaacgg ttgtcttgaa 53880 taaacttcca cacatcaggc aaatcagatt taaccactag ttcaggtgga gtgtgaagca 53940 tatccaatgc tacagtttca ccatctgctg ctaatttaaa gaaatattta agactgtata 54000 gttcatggtc aatatcatct ttagtgtttt tagatgatgt gttgttagtg tttttactca 54060 tgtgctcttt gacatttccg ataagaatat cgcgagcagg aggaacaaag atttctttaa 54120 aatctacatc agattctggg gtagaagttc cataaagatg actaccgaaa tagcttttca 54180 ttactgtttt catcattcag ccttatattc aataacagga catactttag ctttacgagc 54240 ttttaaaaat tcaacgataa tcgatttctt gggttgaata agaggtaaac ctttattttt 54300 cctatcaatg ttttctacgt gtaaagcata atcctttttc catttataat ctttatattt 54360 ttcacgcaaa tgtacaggaa taacaaatga accaataata agtaaaacaa ccaaaagcgc 54420 aagtataaat gctgatggaa gcaaagtcca taaactacca aaaataagcc agcgctgtaa 54480 actttctgca caaataattg tcagccctac gagtatagca cacccaaaaa tagaaacgaa 54540 aaatgtaggg ataacaatag accaaaagta tgcacatagc gtcttaggtc gttgccattc 54600 gtcgttaaac aatttgaata atttataatg ccaagagttt tcattaataa tcataattat 54660 cctttcattg gaggcgtaac ggttgttaaa tacttaatca tagcttcagc ttctgatttt 54720 gataatgaaa tttcttcatt gttttgacga atagaaataa aatccggatg acggtcacca 54780 ccagctttta aaacacacat ataagtatca acttcgcctt caatatttga aatgattgaa 54840 gcagttccac atgaatgcgg tttttgataa atcaatacag cttttcttcc accgtttgac 54900 tgttcatagg cttttaatac atcaagcaaa tcagttcttt tatcaatagc taaaatatta 54960 ttttcatctt caatgttaaa tccttcggat acttcataaa gcgttaccca taaatcaccg 55020 atgtcaataa cagcatttac ttttccacgg ctttcaagag tatgacaaat tttcttgatt 55080 tcgtcataac tcattttaat aatatcatct ccttgactaa gaaagatgtc atttttaaat 55140 tcaacacgaa ttaaaccgct tccacttgaa ataaacatat ttcctcactt tgaaatcata 55200 gttggaatga cagaatcaag ataagtcttt agtgcaatag cttcatcttt ggtaaatgtg 55260 acaatatgtg ctcgagaatc atcaatttgg cgaacaagta cgacatcgcc atcttcataa 55320 gaagtcttga catccaaagt cgtagtataa tttgcagcta ctggattaat aatgctagca 55380 ccgcgatctt tagcccattg aagtttagcc ttttcgggtg tttcgattgt ttcagattcc 55440 aagaattctt tcaccttggt aacgaatgtt gcccaattgt tgatagaaag acacataaat 55500 tcagtttcaa tattaccgcc gtaaaggcca cgataaaaac gaacttggag gtcgcctgta 55560 atattagtta caccggtaac tcctgaggga gcataagata aaatcgcagc cagttccata 55620 ggaagaatag taatattatc gtcttcctgc gtcagaacgt atacattatc acgtttttcg 55680 ataaccaggt caccgaacaa atcagttgtt tcaattacag ctttcatatt atttaccaat 55740 taaagtttca atataagaat caagatttac tttagcttct tccataagag ttttgtattt 55800 aatcttgtta gcatgtccgg agaaagctga ttcatcaata attgttgatg tatgaacagc 55860 tctactatac gtctcaatta attctcttaa tttaaaagcc tgctcacttg tcattacata 55920 ctcctttgaa taatatcaat aatgttgttc accaaattat acgtaaacat tgggtaatta 55980 tattgaatca tcacatacac aacaaacaaa actttcattc tcttctcctt ggcagttgac 56040 aagattacta taccataacc ttgccaactt gtaaaccatt aaatgacgtt ttcgataaaa 56100 ttctgaagct ttgtatgagc atcaaccatg attttcattt cttcctttgc gaaagctgtg 56160 cctctttcac gagaagaaca ttcatagtca gaaactgcat tagcatattc ttcaattagc 56220 ttcattaaaa acatctgctt ttcagttttc attattccac ctaatcattt caagatattg 56280 aactaactta gctttggatt tatccaaatc ctttttagct gtttctatac cgtcgtatga 56340 atatccttca caatgctcaa ctgctaattg atatgaatct atttcaacat cacgtgctaa 56400 tttaatgatt ttttcaaact gttcgtgtgt tagcatactt aaactctcgt attatgatcg 56460 ataatttcat caagaaacat atctaacgct tctaaagcat tatcaacttt agtttcaaag 56520 tctttaatgc ctttattcga aatacccgat gaataccaag caaagtcaat cagctcttca 56580 tctgctttac gaattgaagc cactaattcc ttgattttat ctgcttgctc tatactaatc 56640 attattccac cacatatgac agagagaata ttgcacacgc catgtgagtt gcaacttcat 56700 cacacatatt ataacgtttc ttaagaagtt ctaccagttc ttcactagta acttcatcca 56760 tgtcgacgaa aaaatcacca ttaatgatga cgtagatatt tccttcttga ttgagtgctt 56820 caattttcat gatgttctcc tctttatccg atagttgtat agtatcacag ctcaaacgga 56880 aagtaaaccg gtaaaatgaa aaaagtctcc cgaaggagac taatgttatt cgagggaaag 56940 aagatactta ctctggtaaa acatcccagt aatatcatct atcgtgcttt gaatggctgg 57000 aggcatttct ttataaatgc tgttagattg gtctagtatg cgatcaatca ttttaattgt 57060 gtcggtagga agtttactgg catctggaat tgaaggtgtg tattttctac cagaataccc 57120 caaatattgc tcaccaaatt tatcaatcaa atctggcaat tcggagaaaa taaaatcgta 57180 tgctttgtgt ctagcataac ttttagtttc aaaatgtgca gaatgaaaat aagcttgtgc 57240 agccattaat aaacctaagt attcatctgc ctttgaaggt tttccacttt gtgaaaagtc 57300 gctgaatttc attcagtctc caatttaatg ttcataattc tagcgtatga ttgtgccatc 57360 tccgcgcctc gttctataca ttcgaaatca gaagagcacg ggtcattttt ataggtcgtt 57420 ctcataaaac tatagaattg ttcagatgat tctacgcttt tattttcaaa aagcatataa 57480 acatgtctaa taccagattc cataaattta tcaaaatgag gatcgacatt cgcttcaatc 57540 gatggagata aaacaaatga caatcctagc atggcaaata gtgccgttgc ttttaaggcc 57600 ataaaggcct cctatcattt ttgtcctgta tttactttat gccgatgcac ggccttaact 57660 ttatcaaggt atttttcaaa atttcgcaat ctagtatagt ctgccggaga ttggttgagt 57720 gatacttctc gacgcaaagc tgaaatgata tttccaactt ccctacgaat ttcatctaat 57780 tgaagcacag taagattgcg aagttgcttt tcagttaatt gtagcatata taccccttta 57840 gttagataaa cctatttata acttttgcac taaccgagct ttttagttaa ttcgttccag 57900 tgttttctac acaaagaaac ataaatttca tcaccaatac agatttgatt accttcttta 57960 actggtgttc catcttccat taatcgagct gtcataatcg cttttttgcc gcaatgacaa 58020 actgccttta gttcaataag tttatctgca atcgctaaaa gttctttaga accttcaaac 58080 aattttccag cgaaatcagt ccttaatcca taagccataa caggaacatt atatgtatca 58140 acaattcggc ttaattggtg cacctgttca gtttttaaaa actgagcttc atctacaaat 58200 acgcaatgaa tatctttttg tgcttcagcc catttataga actcgaaaat atccatatca 58260 tctgtaataa tattcgcttc ctgtttaatt ccaatgcgag aaacgacttc gcagacagaa 58320 tcgcgagtat caatagcagg cttaagaact aatacaccca ttccacgttc tttataatta 58380 tgtgcagcag tcaaaagaga agcagatttt ccagcattca ttgctgcata agtaaaaatt 58440 aaactcgcca tcttagtcct tagttaaatt ttctaaatat gtttctaaat cattttcagc 58500 tttatcgata gattttacta attcgtaata tgtttcggca tctccatatt cagaagatat 58560 ttcaaaagac aaatcctttt ctaaactaac aatttcacta actaaaaata atatttcgtt 58620 cttttgttcg cgagtaatca taatgaattt atataatcaa tgagttcttg ttctttatta 58680 tcgaattctt tagaaagttc ttcgtactcg tttgcactaa aaggaccgca ttcattacaa 58740 actttttcca attcgctatt tttatccata acttcgtgga taagagaaaa gagtttgtct 58800 ttttgttctt tactcagact catatattaa atcctagaag ttttaagata attcgctttt 58860 gcttaaatat ttccatcgtt aaatgatcag tatctttttg accaattcca atagcaaaac 58920 ccttatttac ggcaagttca attaaattat caatattgcg taaaacttca tagcgtaact 58980 caaaattatt cattttggtt caccttcttt aacgaaatcc ggataaggat taaatccaga 59040 ataaaatcct tcacctttat gattgctaca acccttgttc gagcaatagc accaataatc 59100 gaaatcacaa gccatttcat cgttgcataa agcaaaaaca accggccact tacacttttc 59160 acagtgggca tttttaagaa tactagtttg gctcataacc atgtaacctt taagcaatat 59220 tcttctacat gttgtttacg acctttctta tcaataaagg tatattcaac gaatgttcca 59280 atgtagtctt tatctacatc atgtggacta ttaattggac atttagtacg gcaaatgcgt 59340 tcccattgac gaataattac tgctttgttt ttaggatcaa acggatgcgg gtaatgtact 59400 ttcataatcc accactatta aatcaatatc aggagtaaac atgtcgatta atttagaaac 59460 cttatcccaa tcgccgccag caataccaca acctatacgc ggaatgtaaa ttactggttt 59520 aaacaaaagg gtttctgcct gtagatttaa ttctatcatg cagtttacta aagcaccata 59580 atcaagatta ggacctggtt cgtattgcgt atacaggtta tagcatatgc caaaaccatt 59640 aggtttatgt ttaaaaacaa tagacatatc gcctaattta tcacgagaac cgtactcagt 59700 agtggtttta tctatttcta aaattttggg ataggctctt gctaattgac ccgctacgcc 59760 tgaacccata gtatgaaaac aattgcaccc gtgcgcaata atattacctt gaagaaatag 59820 ggcgacaata tcgcccttga tatattttac aatcatctag tactcaatcc tcgattataa 59880 gaatctacta aacggtcaac cattgaatga caagcggctt tatctttctc ctccgcaact 59940 gaacattcta aggtattcca ctttttagca tatcgtttta acaatgtatc atttttgtat 60000 ctgcttgatt tatctctttc tccgtcttta tatgcatata ttaatttctg cgcaaattca 60060 gcttggcatg ctttattttt cccacaataa tccgcggcag tacggtttac atactctcta 60120 atttcagtat atgatgtatc tgctgatgca gaagcagaaa atgaaattaa tcctatacat 60180 aaaaccaaaa ttttagtcat ttactatttc caaaagttta ttatttttaa ggtaattagc 60240 cttttctagg acttcagaag catatttaga acctgcttta acattccatc ccgaattata 60300 agaggatatc gcctttctta tatcgccctt atgtatattt aaccaataag aaagttcaat 60360 gtacgcccag gaagctgaat tggaccgttt attcaacatt ctttttattt cagcatcggt 60420 catattataa ccaagttcct taactcttgc tcgcatggtc ggcaaataat tttggaacat 60480 tccataggca tgatgctttg gtttagattt taaattaact ccggcagagc tttcttgcca 60540 taaaatagca gccattatat gacccaatcc gctcttgtgg atatttttgt gtgttttata 60600 ttttccatcc ttagaaaatt gttccccgaa ttgatatgcg taacgcatgt tatcgagttg 60660 gacattactg aaagtatgct cggagctatg tgccatcatt gaaatggcca atagaccagc 60720 gagtagtgct tttctcatgc ttacctcatt gagttttaat tactgcttta gaagcctttc 60780 ctggtaaacg acgactgttg ataattgcca tcctgcactg aagcgacggg tctttgaact 60840 ttgcattagg tttacaaact gtaaatccaa gccaaagatt tccatctgtg atttctaaac 60900 gcccagggcg atattcaacc ccatcaataa aatcctcatc aatgtcagga cgcggaggca 60960 tactcaggaa ttcattaact tctaaaacat ggtcttttat tttgtggaat aattcaaaaa 61020 catatgtctc atcaatctcc cgttgaattg cacgatcaag aagatgctga gaatatttta 61080 gatgaaacga tgagactcct gctgcttttg atgcctcacg aatctcattg ttaatttgac 61140 gaaactccga ctcaaagtga cgacggagct tatttcgacg gataaaaact tctgtgttga 61200 tagtcatgtt attctcctct taactgatag aaaaattata ccacagtcaa gaggaaaagt 61260 aaacagttat tctttaaatc taatcaattt attcatagac tttgaaactt cttcacgaac 61320 ctcatgtaga tttttaagct gttcaagacg ctgctcatag taagcaattt catcttcttc 61380 gagacagtcc tgtgaatctt ctttaagata acgtgcgtag tcctggaaag ctttacggac 61440 tacttcttgg aagtcatcaa gactttgaat tttcttagga gcaacagata cacgacgagg 61500 ggcagtataa tactcgtaac caaaccctgc gcttaattga gccattaata tttttcctct 61560 ggttggaaca ctgcgcgaca agcccacata ctagcttctt tgagtttcgt tttagcaata 61620 gttaactgat cgaggctttc agcataattc ttcgcgagtt catcatcttc acagctatcg 61680 aatgcttccc agaattcatc gtataaagca tcaaagataa gtcctaaacg aacttcagcg 61740 tctttgatag cattcacttt accgattttc tcttcagtat gcggcttata acctttaatg 61800 tcttcaatca tatttgactt cctcaccagt acataaatca tattcaacta aacgaatagg 61860 ttcatgaatg ccatatcctt gaacagaaat ttctgtcgta ggataaattc catcaatatc 61920 acccatattc caggcttcat taaattgttg ttcgcctgaa ttactaaacc actcggcgaa 61980 agcatttagc acatctttag aaccttcaat aattatcttt gccattacaa actctcagta 62040 aaggtacgag cgataacgtc gcgctgctgt tccggagtca gagagttaaa gcgaactgca 62100 taaccggata cacggatggt cagctgcgga tatttttccg gatgcttaac tgcatcttcc 62160 agagtttcac gacgcagaac gtttacgttc aggtgttgac caccttcaat tttaactgta 62220 ggttgtgttt caatttcaat ttcacgggca tgcaaaccgt agaaaatttc tgggtctaca 62280 aaagagtcct ctttaaaggt tttagagaca ataattcgtg cttgaatacc atcttcaaaa 62340 taaatagtac ctttatgtgt gccttcaaga atttgatatg ctttcatata aacctcaatt 62400 agaaaataaa tttatccaag attgttcttt aattaaaaat ggctcagaat catatgccat 62460 taaactttgg gtgattagtc ctttaaaagg tccatcaata aattccatgg taaaatatgg 62520 aattttattc attaactgcg cgttaggagc agtgcacaaa actctgcatc ctttgaatac 62580 gcctttttgt aatttgtatt gcttgggata aaattcgctc aaaatgttat tatttgccaa 62640 aatttcaaaa tgattcacca atttattttt aatagttttt ggcgaaaaat aaagatattc 62700 gaaaagctgt gtgtctgtca tcattgcatt ccaatcacaa aaaattgagg acgaactgtt 62760 tcacctgttt cagcattata gcttcgacaa cagtgttgta ccgttttaat atggatattg 62820 taaatcttat ccatatcagg agctttaata ggttcgtcaa ttatgtacaa gatacgagaa 62880 agcgataacc cacggaattt atgaccttca ttaccgataa aactacggac agaatcagta 62940 aataaacgga atcgaatatc atcattagaa taacgcgaaa attccttttt aatgttattt 63000 gcagaaattt tagcgtaagc tgaagtatta gaaagaacaa taactgttcc gccatcatac 63060 aaccaattag cagcaaagtt agtcacagca attgatttac cggattgacg tccaccatct 63120 agtcgaagtg tacaatactg tttaagtaag tcttcaaatg gcgggatata ttcgttttta 63180 caaatttctt ctactctagc atcagaatgg tgtgtaaaag cattcatcag ggatagataa 63240 ggaccggtta aaaatgttct cattttattc tctctaagtt tgggccattc cgtggcgcat 63300 gaattgtcca tttctgcatt tacccattac cgcacttggg ctcgacctta tcacaggttg 63360 gcgggaatcc ctcacagaat catgaggtcc aggttgttcc catattattt gaacgattta 63420 acgtactgaa tagaaccctt actattcacg aaagcgattt taccattttt gttatacatg 63480 gtagcagtac gttgataacc ataagtttgt ttaccagatt gataaccaac taatgcaaaa 63540 ttatcttcac ccattttatt ctgcttagcg cgaatgcgtt catggccatg tgccataaga 63600 accttagcat cacccgttgc aatggatcta cgagtttttt catcttcaac tgtattaaca 63660 aagtcgtcaa atgaatcaaa tttagcatga gatttattat acagttttcc atctactgca 63720 taattatatc cttgtacatc catctcaact tctgtaccgt catccaatac agcagtgatt 63780 ttctgtcctt ttttaaattt caaaagatca gtaaaagatt cagcaataat ttgagaatta 63840 atagctgctt cagtaataaa ttcttgatat gttttcatgt gtatccttta atttttattc 63900 tttagggaag tttttagaat atgcatcata aagcttattt ccaatacggc ggaaaactct 63960 agccgcaaaa cgattttctg ggtttttaat catgatttgc atcatataag tacccgcgtc 64020 agaaagagct tcttcatagt acccgttaat ttctttaaga gtcctacgtt taccaccagg 64080 accatcaaca gtgattttcc atttacctgt agaagtgcga cttggcggct caacttgttc 64140 aatccagata taaccgcctt ctacacgttg tcctgcagca gattctgcaa taaattcttt 64200 atacgttttc atgtgtttcc tttaaatatt ttaattagta actgtgaata tactatcaca 64260 gttctaggag aaagtaaaca actttataga tttttatacg cgtcccacgt accagttcta 64320 aacgtggcaa tgactcgttt tgcacggtta ggtgtttgat tataccatct acttttagct 64380 aagttaactg ctgcttcatc ccagcgtttt tgttgaagca tacgtaaaga attagtaaat 64440 cctgctacgc cggtttctcc catttggaag accatattaa tcaatgcgca acggcgaaca 64500 gcatcaagag aatcataaac tggttttaat ttagcatttc tcagaattcc gcgaacagca 64560 gcatcaacat cctgattaaa gagtttttca gcctcatctt ttgtaattac accattgcaa 64620 ttacgcccaa tagctttatc taattcagat ttagcaacac ttagtgatgg acttttagta 64680 agcaaatgac caatgccaat agtgtaatag ccttctgtgt ctttatagat tttaagtcta 64740 agaccttcat ctatacgtaa catttcaaat atattcataa tacctcctaa gtatttatag 64800 aaggtattta taaattaaaa gaggttgttc attattcggt aaagtgaagg acccatcaca 64860 tattgccact gagtgcgagg aataagagca aaagcatcca tctctggaat cataacgcca 64920 tctttatttt caaaataaga ctcgcaatgg caatttctga acatctcatg ctctactgga 64980 atcgtataat aaaacaactg taggtcttta ttactagaat atttaaatac acctaggtct 65040 tctagaaggt ctggattata attgctaaaa ccggtctctt ctaagcattc tcttcgtgct 65100 gcatctaatg cgcttaaatc agaattttct acacggccct ttggaatatc ccaacgatgt 65160 gccatcattc caggcttacg agaaccagta acccgaccca taaataaatc tttatcttct 65220 gtcataaaaa taataccagc tgataatgtt ttcattttaa tttcctgcat tcagtgataa 65280 agttatttaa attttgagta tatttctttt catcaaaaat cttttgctgc ctacgtaacc 65340 gccatggcat ttcaatgaac acgcaccata ttcctgatag tactgctgct gtaaaaatat 65400 taacaagtat aattaaaaga atccaatctt ccgttctgcc tactggactt tctccaaaga 65460 agcaaaatac aaatgatgtc acaggaaaac taataatata ccacagaata accttcttat 65520 ctgtgaacca atcagcgttc gttaacttag cacgaccatt ttgaatacac acgaatttat 65580 catctgttac agtagatggc ttaactgctt gatatcccat tctaaactcc ctaattaatc 65640 gtttctttgt atcttcagaa cagccgctcc agtcaactct atcgactgaa atgccatcgt 65700 ccccatcatc taaatcatac cagcgagttt ttaaaatcat ttgattttcc tacaatcatt 65760 cacgaattct ttcattgatt cattttcaat ataagacatg tagttattat attcttttaa 65820 ttgtattttg taatcctttt ttctttgcca atttatttta aaattatcat aatgaaaata 65880 taaaatgata ctaaagaatg aaaataatga aattgctata gtataatgaa gttcactcca 65940 aacttctatt atatctacta taccgctgac gttactgcgg atgtttaaaa taatacagtc 66000 aatcattaat ccaataagac taccagcaag agctgcagcc aacgccacag caaaaattaa 66060 aaatgactca gaaaaagaat atttgacttt atttagtttt ggcttttgca tcgtgattcc 66120 ttaacaaatt tcataatttc attaaattca tacatattta gtttaagctg gtgttccttt 66180 ttaatctttt tacactgagc tttccattcg cgtacgcgtt tacgataatg tcttccttga 66240 taccagtatc ctacccaatt tacaggtact aataaaagtg gaactattaa tggaagaatt 66300 agcattaaca caagtatttc gccagaatca atatcagtca taacatctaa aacacctcca 66360 ataatcaata gaattacaaa tgatataagt ataacaggac ctattaatac atcagtagaa 66420 attatctgac gctttaattc atacttcaaa ggtttacttg gaaggtatag tgatggcttt 66480 gacatattct ctacattcct taacaaattt ttctagtaat aaatcgcttt caaaattggg 66540 attttccact aatttatcaa aaagatcatc aacaatagtc aaaatattct ttttactaag 66600 aatacgctta ttttcatgct tcgtttcaga atcaactata agagtaaaga aatatttctt 66660 tccctgaaat tttaccgtag tatcaatata gaataaattt gacttttgta aattacgttt 66720 aaaccatgcg tcacttaaac tataaacacc gagataatca aaatcgtcgt ttaaataaca 66780 aactgaccat tcaggagaaa tgaaatcagt aaattcaaca tcaaaatcac atgtcaatga 66840 ataaattgat tcaatattgt taataagtat tccaggacgt attaaagact ttttacctct 66900 agaaaatctt ccagaaagac tttcatcagt ttcatatgaa gaaccccaat aataattacg 66960 tccttctgcc atacgtttaa gagcatttaa taattggtct ggaacatcaa cttgtctttg 67020 gaattcttca aacattgaat tgaaatcact ttgcattttc attcctattt actccaagta 67080 ataggggccg aagccccttt atcattattt cagagaatta atgtattcct gaacatcagc 67140 agaggtagtt tcaaccccag aaatattgcc attaaaggtt tcaactcggg caagagtatc 67200 ttcaatatca accttagtca gcgctgcaat ttcaactaca tcatcagcag tactaattcc 67260 gagggcattc gcggcgcgag tttcacggat atattccaat ttaactgcaa gttcttggcg 67320 agcatcatct aactcaacta ctttcttggc gatttcaatt cgcatttcag cataaccatc 67380 agctttagta gtcaactgct cagctgttcg acgatatagt aaaccaagtt tagcatgcat 67440 tgttacatct tgaccttccg aaagaagctt gcgaatttca cgctcttttg attcggcctg 67500 cttattcttt tcgacaataa gttcacgaat acgtttttct tcattaatag atttaataga 67560 agcagttttt agatctttaa ttttatcaag tagttttgct gctgcggcag tatactgttc 67620 ttcaacagat agatttttag ccatagcaga accaagttta gtgcgaataa actcaacaat 67680 tttcttcagt gtgttcatag tatttcctta ggttgattaa gatttaaaat ccgtgagagt 67740 attagtatta tactctatct tcaagttatg ggctcataat atctcaatca tgagcctatg 67800 taaacttatt tcatattatt gaaatattct tctgcgattt cgtcgttatc atggtaaact 67860 ttagaagaca atttaacata accttcagca gtgaacatgt taatcacaac ctttacagta 67920 taccactgac cgtcttcatt gcccattacc gcataagttt caaacatcgg atgatcagga 67980 ccgataactt taatatcatt cactgtacga ccgaaatctt ctgaaacaca tttcataaag 68040 aagttgaaca gttcgccgta attatccatt tcgttctcca agttgttttc tgtatcagta 68100 gttgatagtt gtatagtacc atggaagaac agggatgtaa acagttttgt gaaaaaattt 68160 ttaaaaagtt ttggggaatt ctagggcagg gaggggaaat caaaggatag gataatatat 68220 tataaagggt agaaactaaa tgatgtctag agaggcctgg aaaggcctag ataccaaaaa 68280 gccccaacct ttcggctggg gctaagaatg ttatttgatt tgtttagcag accaaatgcg 68340 gtctttaata attttttgga tgtcttcaac atacccaaga gagtgagcat gtgggttatc 68400 tttgaaacta taagcacgag ccagtttttg gccttcagtt ttgattacta aaagctcttt 68460 aagaatagct tcatatttgg agataattcc tttaacaata tttttctctt gtgcgacttt 68520 aggatctgct ttaggagcag gtttacctga agcctttgca aaagcagcgc cagtagcaac 68580 taaacttttc caggccatac taactgcatt tcccgtaaat ccttccgctt tcatgtcgcg 68640 tgcgaactgg aatcgcgatt catcagaagc atctttgtaa gaatatttac ccgctgcaat 68700 ggctgctttt gcgacagctt gaatttcggt gctagatgct tcatttaaca ccgcttcatt 68760 taaaaattga gtatatgatt tcatcttatt tcctgtttta attcgtggtt ttaatatact 68820 actatattta taccaaaaag ccccaacctt tcagtcgggg ctaagccttg cggcaacctt 68880 gtcggggttc cacctgctaa ggcaagtgtt tgtacgaaac gccgggattc gaacccggtt 68940 attaagcagt tgacgctact caatattttt aaaaggccat atctcgacca tatccgaacg 69000 ttccgtcaaa aacgctactc ggtttacggc aaagatattt cctcgaatcg ataattcggt 69060 gcgccgtttc tgctgtgata gtaaagagcc agaacacagt aaaactgtgg gaggaaacta 69120 tactccaggg aacatcagtc cgacgactta ccggtagcga cccggtttct tagtattctt 69180 ttaaagcatc aacctgttca cgacgtttac gccataaatc aattacttca tacgcagatt 69240 cagcatttcg aattggacgg catttatata aagacttgtg attttgatat tgtgtagata 69300 acggaatttt atctaaaagg tctttacgtt caaaatattc gtaaccatct aaaccaaatg 69360 aacgattttt gagaaattgc caatgaccaa attcgttttc gacataaaca taatctgcat 69420 gctgataaag caaattaatt acacgttcag aaataacagt atcattatga ttaaaataga 69480 atgttaaatc atgaactact aaataaacat tacctttcat attttcctca cttataattg 69540 gtcgaggcag tagggatcga acctacgacc caggacttag aaggtccttg ctcttccttc 69600 tgagctatgc cccgtaattg gggtgaccga tgggagtcga acccatgact acgagaatca 69660 caatctcgag ttctaccaac tgaactacgg ccacattaat acctactcca acaatcatga 69720 tgtcttcaca cgaaattaag agaagagtga tcagttcaac ccctataatc gcgtcaagta 69780 gatattaatg tgacagttgt cacaaatttg gcggacgtga taggattcga acctataacc 69840 aatcgcttaa caggcgatcg ctctgccatt gagctacaca tccaaattgg tggggagtga 69900 tggagtcgaa ccacccgagt cgcaatgaca atgaatttac agtccacacc gctacctcta 69960 cgggataact cccccttaat ttggtggccc tgggtggaat tgaaccacca tctggcgatt 70020 atgagtcgct tgcttgaacc ttccagctac agggccttgg tgctgattga cggaatcgaa 70080 ccgccgacat cctcattaca agtgaggtgc tctacctact gagctaaatc agcaaaactg 70140 gcggaggcga taggatttga acctatgagt cgccggagcg actgccggtt ttcaagaccg 70200 gtgcattaaa ccactctgcc acgcctccag tctccataca aggatttgaa cctacgacat 70260 tctgctccca aagcagacgc tctaccaaac tgagctacac ggagtaaatt aaattggagc 70320 ggataatgag aatcgaactc acatcatcag attggaagtc tgaggtaatg ccattatacg 70380 atatccgcaa atttggtgcg agaagtggga ctcgaaccca caaggaaata attccgcagc 70440 attttaagtg ctgtgccttt accaatttga ccattctcgc gctgggaata aaggactcga 70500 acctttgcat ctagcagtca aagtgctatg ccttaccaac ttggctaatt cccaattatt 70560 aacaaaggct ctctaacaag aacccttgat gatagagggt attaatcagt gcggtatgag 70620 ttaataataa caaataattc ttaaagcata tttaccattt atgataatac atatttacga 70680 tgcattcaag gcccaaagga ttcttgaaaa tatcatattc aagaggacct ttttctgttt 70740 caataaagaa atcaaaattt actgtattaa atttacggtc ttccttcact aatttaactt 70800 gagaagatga acggtcaaca taaacctttt caacttcaaa acatgttaaa acgccataat 70860 catcaatcaa ggctttagct gcttcttgat catatttata tccattttca atggatgata 70920 ctttcgcata aagaatcatt attaaccttt atcaacaata gtatgtgtat gggcatttac 70980 gatttgccac cagtcaaaac tatcgccaaa tcgttttgat ttattgtctt caataatttg 71040 gcgtaattca tcttctgttt cagcatacgc aatcaaatca tcatatccac cgcaaggata 71100 gtaattatcg cctgcgaaca aaagaaaatt tactttagat gggtctacat aataatgctc 71160 tttaggatat ttagttcctt tccaatcagt tacttcaaca taacaataag aaaatccatt 71220 tttactttca acccaactcc acgcttcaaa aggagtatta aaaactctat caggtattaa 71280 attaccttca aaatgagaag gatttgcata atccccagca taaacataat attcgttaat 71340 attcatttat tcacctttag aaattttatc cataacaata gcgattaaac caattaaaaa 71400 tgctactaca agtgaaaaaa cattttctgc tgtagtcaat aatccgcata taaatccaac 71460 aaacattgaa aaactaaatg cagaagcaga aattgcaata gcaacatttc gaattaattc 71520 acagcgtttc attttattct cctcagtagt tgatagggta atagtatcac aactaaaacc 71580 ctatgtaaac aactttgtga aaaatttatt acaaaagatt tttagcaata attttaagct 71640 gagctactga aatatgcttg gctttaaaca aagcagtttc ttcagcaggg gagataatga 71700 ttgtggcacc atctttctta gcggaccatc catcacccag gtaaacagta cctttaactt 71760 cttcaccatc aaccaggcta atcatcggtt taccttcacg tcctttgttt gctttaataa 71820 cttcagaagt aagggtcgct tcagtcaaag tagaagcgtt agtggttgaa gtgaattctt 71880 gataagtttt cattttattt tcctaattaa ttttgacgag gtaatagtat cactacctca 71940 tcagcatgta aacaactttg tgaaattatt ttaaatcatc tgcccaatcg aatttaagag 72000 gctctttgta ttcacgatct aatacgaccg gaatttgtac atcaccgcta aatgataagg 72060 gcccaacatt ataagacaat gttatatgcg gtgtgtaatc atcaaaatca tgtgtagcac 72120 ctagtgcccg cgcatacatg tgtcgacaac gcagatattc agaatctagt acaagtacaa 72180 gagtcgatcc atcttgtgtt ttccatactt ctaaatgtcc agaagaagct acttcaaaac 72240 ttccgcttga tggaacatac ggaacattta ctcttgaata acatatggtc gaatgaattt 72300 tttctctagg aactggatta ggaacacgta aagagcgctg gagttcttcc agcgcatcaa 72360 gtgttaattc tgaaaactta gctgctacat aaagacccgt tgaaaagtct ttaaattcca 72420 tcattcttca tcttttgctt catctgcaga ttcagcagta agattcttga cagcttcaac 72480 gatttcttca actttaatag tatcgccagt gatacctact gcacgagcaa tttcagccaa 72540 agttccttgc agaattttgg attcttccat tagacgagtc gcttggtcct gcgtatcaag 72600 aatgcgagat ttcagagtta cgatttcagc agacagtttt tgttcaatag tttgttcaga 72660 cattatagta cctttagtgt atttttaatt ttagaaaaaa gttcttcaag agaaccatcg 72720 tttgtaatta ctaaatcgcc atcacgaatt ggcaatccag cttctgtaat atgtgtatca 72780 ttggattttt gaccaggacg aactacatga attactgtag cacccatcgc cctagccgca 72840 tccatttcat gatcttgacg ggtatcagga acgatataat aatcataacc tgagttaaat 72900 ttatcaagat aatctaaagc aaataatttt acccagtaca tgcggtcgaa gttattaaca 72960 atcaaatccg tacctagggc ttgcatcaga cgacggactg accattgatc ttcaatatta 73020 tttataacgt cagcaatctt gttaaatgct acgaaattaa ctgcgtcatc aaaaacaaac 73080 acacctttaa ttgggctttt actattaaga tagcaaaatg cttgttccat aatcgtaatt 73140 acttctaatt tagtcagatt taaattagtc tcacgatcat agtcaattcc ttcaaactct 73200 ttacgagtta agcaaggata gtcagtgttt gctgcaaata caccccatgc ataagccaat 73260 gcatccttaa taggaccagc aagttgatat ttaactgcag aataattatt cataataaaa 73320 tctgcagtag tatcttttcc actacgcttt acaccactta aaaagattag tttcatatgt 73380 ttctcctcaa atttagttaa gattataaca catgaaactg aagcattaaa cttctgctat 73440 aattttgcca tctttttcta cttgaaaata cgtataagga atcgttgctg tgcatactaa 73500 ggctgggtct gaatcttccg tgtagctaaa ttctacttca gacaggtcag aaacccaagg 73560 cttataaaaa tttattgaca tcacgatttc agttttacta ttatctaaaa tgtaaagcgt 73620 aatgtattca ggacctgttt tttgggcagt attttcgcct gtaagatagt tactagttcc 73680 tagcatccat tcatacattc ctatccacga cttaagctct tcatcaacta taaatctcac 73740 gatgagtggg tcgtactcaa atgtaacacc tggacgttgc gctcggccta gtccaaatgg 73800 cccagtcacg gtatcagtaa caggtattct aattcctgga ataggaactg actgagcatt 73860 taaagtaaaa gcagatgtag tattactatg tggtattgat actacaaagt tagttgtatt 73920 tgcttggtta aaaatttgtt gcagagcttg cgacatatat tcctcataat gctttatagc 73980 tgttggtggt ataatgggtc taagtccctt ccattcaatt ccatttagaa caaacaacag 74040 aaaagaatgg aagataatag aattagatat ttgaccagac tttgtttgca gagaaacgtt 74100 ttccttttga aacgaactgc tgaagtggca ttaacacaac gttcgcccag tctttcgggg 74160 cgatttcaac taggctaccc ataatattac caggtatata tgccttaatc atttggtctg 74220 cacccctaaa tcctttcact tgactccaat caatttttaa tttcgtttta ttagtaatag 74280 taggtgtatt tgcatattgc tttaaaagct cttctagaaa ttgctgacga gctttaggtg 74340 gaatatagtg caagtttaat ccgtacatta aattatgctt acctaaacca aggtaaatta 74400 tcaaaggaaa tttatcccaa taaggaagag tttctttgtg tttagcatcg taagcaaaag 74460 catatattcg tcccggctga gggcgaacaa ctttatgtcc ttttacttgc ttaatagttt 74520 cagcaaacca ttttctggtt ttattattaa ttgctgcacc ttcattacga attttatcgc 74580 gcaatgtttg tctgaatgaa tttatcataa gcagttgtct ttcttgctta ttgagcttat 74640 tcattggttt tgattcaagc ttttgaatct tttcagctgt tttaattcct gaagcatatt 74700 ttgacattgc cgaagtaaac gtagagtatt tgattcctct ttcttcagca aattgttttc 74760 ctgtcattcc ttttgctttg gcctttttat attcaagacc tatttgaatc catttctttt 74820 cgtttaatga ttgcttaacc tttggaactt ggggagtgct ttcattaatt atttgaaaaa 74880 tagccattat gcccccttaa agccaagagc tcgtaatcca tcttctgtta gaattctaaa 74940 ttttattcca cgcttttcag ctaaagattg tgctgctttc catttgtcag tgttcacaga 75000 ccaggtataa atttcattca taaatctttt cttcgctgcg gttgttagat gtgctggttt 75060 aactggtggt tgtgtttctt ttttaggttt tatttcaata aaaaattctt gtccagaaga 75120 atctttcatc caaatatcca tgaagtatct acgttttttc ccttctgcat tacaaaaata 75180 aggaattact gctgtttcac taccccatgc aataatttct ggatttttat ctaaccattc 75240 aaaaaagaat ttttcccaat ttgatctata cgtaattttt ttagggtcac ctctatattt 75300 tgatatattt ttaggaaccc attttccaga atatgccatt ggattctcct tataaataga 75360 taatatattt ataaacagga gggcccatgc tctttacatt ttttgatccg attgaatatg 75420 cggccaaaac ggtgaataaa aacgcgccga ctattcctat gacagatatt tttagaaact 75480 ataaagacta ttttaaacgc gctcttgcgg gataccgctt acgtacttat tatattaaag 75540 gttcaccacg cccggaagaa ttagcaaata ctatatatgg aaatccgcag ttgtattggg 75600 ttttattgat gtgtaatgat aattatgacc cgtactatgg atggattact tcgcaagaag 75660 ctgcttatca agcatctata caaaaataca aaaacgtagg tggagaccaa atagtatatc 75720 atgtgaatga gaacggtgaa aaattttata atttaatatc atacgatgat aatccatatg 75780 tttggtatga caaaggcgat aaagctagaa aatatcctca atatgaagga gcgcttgctg 75840 cggtcgatac gtatgaagct gctgttcttg aaaatgaaaa acttcgtcaa ataaaaataa 75900 tagcaaaatc agacatcaat tcatttatga acgaccttat acgtataatg gagaaatctt 75960 atggaaatga taagtaataa ccttaattgg tttgttggtg ttgttgaaga tagaatggac 76020 ccattaaaat taggtcgtgt tcgtgttcgt gtggttggtc tgcatccacc ccaaagagcg 76080 caaggcgatg taatgggtat tccaaccgat aaattaccat ggatgtcagt tattcaacct 76140 ataacttctg cagcaatgtc tggaattgga ggttctgtta caggaccagt agaaggaact 76200 agagtttatg gtcatttttt agacaaatgg aaaactaacg gaattgtcct tggcacgtat 76260 ggtgggatag ttcgcgaaaa acctaataga cttgaaggat tttctgaccc aactgggcag 76320 tatcctagac gtttaggaaa tgatactaac gtattaaacc aaggcggaga agtaggatat 76380 gattcgtctt ctaatattat ccaagatagc aatctagaca ctgcgataaa tcctgatgat 76440 agaccgctat cagagattcc aaccgatgat aatccaaata tgtcaatggc tgaaatgctt 76500 cgccgtgatg aaggattaag actaaaagtt tattgggata ccgaaggata tccgacaatt 76560 ggtattggtc atcttatcat gaagcagcca gttcgtgata tgacccaaat taataaagtt 76620 ttatcaaaac aagttggtcg tgaaattaca ggaaatccag gttctattac aatggaagag 76680 gcgacgactt tatttgagcg tgatttggct gatatgcaac gtgacattaa atcacattct 76740 aaagttggcc cagtttggca agcagttaat cgttctcgtc aaatggcgtt agaaaatatg 76800 gcattccaaa tgggcgttgg tggcgtagct aaatttaaca caatgttaac tgctatgtta 76860 gcaggagatt gggaaaaagc atataaagcc ggtcgtgatt cattgtggta tcaacaaaca 76920 aaaggccgtg catcccgtgt taccatgatt attcttacgg ggaatttgga atcatatggt 76980 gttgaagtga aaacaccggc taggtctttg tcagcaatgg ctgctactgt ggcgaagtct 77040 tctgacccag ctgatcctcc tattccgaat gattcgagaa ttttatttaa agaacctgtt 77100 tcttcatata aaggcgaata tccatatgtt cacacaatgg aaactgaaag cggtcatatt 77160 caggaatttg atgatacccc agggcaagaa cgatacagat tagttcatcc gactggaaca 77220 tatgaggaag tgtcaccatc aggaagaaga acaagaaaaa ctgttgataa tttgtatgat 77280 ataacaaatg ctgatggtaa ttttttggtt gctggagata aaaagaccaa tgttggcgga 77340 tctgaaattt attacaacat ggataatcgt ctccaccaaa tagatggaag caatacgata 77400 tttgttcgag gcgatgaaac taagacggtt gaaggtaatg gaactatcct agtcaaaggt 77460 aatgttacta ttgtagttga aggtaatgct gacattacag ttaaaggaga tgctaccact 77520 ttagttgaag gaaatcaaac taatacagta aatggaaatc tttcttggaa agttgctggg 77580 acagttgatt gggacgttgg cggtgattgg acagaaaaaa tggcatctat gagttctatt 77640 tcatctggtc aatacacaat tgatggatcg aggattgaca ttggctaata tacttccaat 77700 gagcgctgat ttaggagaat ccatggaagg ttcttctatc gacgtcacct ttaccgctca 77760 attagaaaca ggtgaaacgt tagtatctat aaatataact agttacgaag aaactcctgg 77820 ggttttagta gaagaaagtc gcttatacgg aacatatgaa tctgtgtttg gatttggaaa 77880 tgacgcgttg aaatatcgtt taggtgatga atttaaaact gctgcttcat gggaagaact 77940 tcctactgat tctgacactc agttgtattt gtggaaagct cctcagaatc tccagaagac 78000 attcacttac gaagtaacat taatatatga ctaccaagaa caaagtgaat ctggaggttc 78060 tggcagtaat tctaggtcat cttctgatac tactgaaccg acagatcctc ctgctccagt 78120 aagaaaaact ctcgttaaaa attatactaa aactatagtt ggaaattgga gtcgttgggc 78180 taataaatta agaagctatg tgtatgagag gtcatagatg tcaggattaa gttatgataa 78240 atgtgttact gctggtcatg aagcatggcc tccaacagtt gtgaatgcta cacaaagtaa 78300 agtattcact ggaggaattg ctgttctcgt agcaggtgat ccaattacag aacatacaga 78360 aattaaaaag ccatatgaaa cacatggcgg agtgacacaa cctagaactt ctaaggtata 78420 tgtcacagga aagaaagctg tccaaatggc tgatccaata tcatgcggtg atactgtggc 78480 tcaggcatca tctaaagtat tcattaaata ggatttaaaa tggcaaatac ccctgtaaat 78540 tatcaattaa caagaacagc aaatgctatt cccgagatat tcgtcggggg tacgtttgct 78600 gaaataaaac aaaacctcat tgaatggctt aatggccaaa atgaattttt ggattatgat 78660 tttgaaggct caagattaaa cgttctgtgc gaccttttag cttataatac attgtacatt 78720 cagcagtttg gtaatgctgc cgtgtatgaa agctttatgc gtactgctaa cttacgaagt 78780 tcagttgttc aggctgcaca agataatgga tatttaccta cttcaaaatc cgctgcacag 78840 accgaaatta tgttaacgtg tacagatgca ttgaatagaa attacattac tattcctcgc 78900 ggtactcgct ttttagcata tgcaaaggat acttctgtta atccatataa cttcgtttct 78960 accgaagacg ttattgctat tcgtgataaa aataaccaat attttccacg attaaaatta 79020 gcccagggac gtatagtaag aactgaaatc atttatgata aattaacacc tattatcatt 79080 tatgacaaaa acatagatag aaaccaagtt aaactatacg ttgatggagc agaatggatt 79140 aactggacaa gaaagtcaat ggttcatgct ggttctacat caacaattta ctacatgcgt 79200 gaaactattg atggaaacac tgaattctat tttggcgaag gtgaaatttc tgttaatgcg 79260 gcagaaggag ctctaactgc taactatatt ggaggtctta aacctaccca gaactctact 79320 attgttattg agtacatcag tactaacggt gcagatgcga acggtgcagt cggattttca 79380 tacgcagata cattaacaaa tataactgtc atcaatatta acgaaaatcc aaatgatgac 79440 ccagattttg ttggggcaga tggcggtggc gatccagaag atattgagcg tattcgcgaa 79500 ttgggtacta ttaaacgcga aacccagcaa cgctgcgtaa ctgcgaccga ctatgataca 79560 ttcgtttcag agagatttgg ttctattatt caagctgtgc agactttcac tgattctact 79620 aaacctgggt atgcatttat tgctgctaaa cctaaatcag gattgtattt aactactgtg 79680 caacgtgaag atattaaaaa ttatctcaaa gactataatt tagcgcctat tacaccgtca 79740 attatttctc ctaattatct ttttattaag actaatttaa aagtcacata tgctttaaat 79800 aaactacaag aatccgaaca gtggcttgaa ggtcaaataa ttgataaaat tgatcgctat 79860 tataccgaag atgtagaaat ttttaactca tcttttgcca agtctaagat gttaacttac 79920 gtagatgatg cagatcattc tatcattggt tcatcagcga ctattcaaat tgttcgtgaa 79980 gtacaaaact tctataaaac gcctgaagca ggtattaaat acaataatca aataaaagat 80040 cgttctatgg aatctaatac gttttcattt aattctggac gaaaggttgt aaatcctgat 80100 accggtttag aagaagatgt attatatgac gttcgtatag tatcaacaga ccgagattct 80160 aaaggaattg gtaaagttat tattggtcca tttgcttctg gcgatgttac agaaaatgaa 80220 aacattcagc cgtatacagg caacgatttt aacaaattag caaattctga tggacgcgac 80280 aaatactatg ttatcggtga aataaattat ccagctgaca tgatttattg gaatatcgct 80340 aaaattaatt taacatctga aaaatttgaa gttcagacta ttgaattata ttctgaccca 80400 accgatgatg ttatctttac tcgcgatggt tcactgattg tatttgaaaa tgacttacgt 80460 ccacaatact taactatcga tttggagcct atatcacaat gacagtaaaa gcaccttcag 80520 tcactagtct cagaatttcc aagttatccg ctaatcaggt gcaagtacgc tgggatgacg 80580 ttggtgctaa tttctactat tttgtagaaa tcgctgagac aaaatcaaac tcgggaaaaa 80640 atctcccgag taatcaatat cgttggatta atttaggata tacagcaaat aatagtttct 80700 tttttgatga tgctgatcca ttgacatcat atgttattag agtagctaca gctgcacaag 80760 attttgagca gtctgattgg atttataccg aagagtttga aacttttgct acaaatgctt 80820 atacatttca aaacatgatt gaaatgcaat tagctaataa attcattcag gaaaaattta 80880 ctcttaataa ttctaactat gttaatttta ataatgacac tataatggct gcattgatga 80940 atgaatcgtt ccaattcagc ccatcatacg ttgacgtttc atcaataagt aattttatta 81000 ttggtgaaaa tgaatatcat gaaatacaag gttctattca gcaagtatgt aaggatatta 81060 accgagttta tttgatggaa tcagaaggga ttctatatct ttttgagcgc tatcagcctg 81120 tagttaaagt atccaatgat aaaggacaaa catggaaagc tgtaaagctc ttcaatgacc 81180 gcgtaggata tcctttatct aagacggtat attaccaatc tgcaaacaca acatacgttc 81240 taggatacga taagattttc tatggccgta aatcgactga tgttagatgg tcagcagatg 81300 atgtcagatt cagttcacag gatataacat ttgctaaatt aggagaccaa cttcatttag 81360 gattcgatgt tgaaatcttc gctacttatg cgactttacc agcgaatgta tatcgtatag 81420 ctgaagccat tacttgtacg gatgattata tctatgttgt tgccagagat aaagttagat 81480 atataaaaac gagtaatgca cctatagatt ctgacccgtt atcaccaaca tactcggaaa 81540 gactttttga acctgacaca atgactataa ccggaaatcc taaagcagta tgctataaaa 81600 tggattctgt tggtgataaa gtttttgctc ttattattgg tgaagttgaa acattaaatg 81660 ctaatcctag aacttcaaaa ataattgatt ctgctgataa aggaatatat gttttaaatc 81720 atgacacaaa aacatggaaa agagtttttg gcaacactga agaagaaaga agacgtattc 81780 aaccggggta tgcgaatatg tcaactgatg gtaaattagt ttcgctatct tcgagtaatt 81840 ttaaattttt aagtgataat attgttaatg actctgaaac tgcagcaaag tatcagttaa 81900 ttggtgccgt taaatatgaa tttcctcgtg aatggttagc tgataagcat tatcatatga 81960 tggcatttat agcagatgaa aaatctgatt gggaaacttt tacgcctcag ccaataaaat 82020 actatgcaga accattcttt aactggtcta aaaaatctaa cacacgatgt tggataaaca 82080 actctgatag agctgtagtg gtttatgctg atttaaaata cactaaagtt attgaaaatt 82140 ttccagaaac atctccagac agattagttc atgaatactg ggatgacggc gattgcacta 82200 tagtaatgcc aaatgttaaa ttcactggat ttaaaaaata tgcatctggg atgctttttt 82260 ataaatcctc cggtgaaata atttcttact atgattttaa ttatcgtgtt agagatacag 82320 tagaaattat ttggaagcca actggagtat ttttaaaggc atttttacaa aaccaagaac 82380 atgaaactcc ttggtcgcct gaagaagagc gtggattagc tgaccctgat ttaagaccat 82440 taattggcac aatgatgcct gattcttatt tgttgcagga ttcgaatttt gaagcatttt 82500 gcgaagcata tattcaatat ctttctgatg gatatggaac tcagtataac aatttacgaa 82560 atttaattcg taacaaatat ccacgagaag agcatgcgtg ggagtatttg tggtcagaga 82620 tatataaaag aaacatttat ttaaatgctg acaaacgtga tgctgttgca agatttttcg 82680 aatcacgtag ctatgatttt tattctacta aaggaattga agcatcatac aaatttcttt 82740 ttaaagttct ttataatgaa gaagttgaaa ttgaaattga atctggggct ggtactgaat 82800 atgacataat cgttcaatct gattctttga ctgaagattt agtaggacaa acgatttata 82860 cagccacagg aagatgtaat gttacttata tagaaagaag ttattctaat ggtaaattgc 82920 aatggaccgt aactattcat aatcttttgg gaagattgat tgccggtcaa gaagttaaag 82980 cagaaagact tcctagtttt gaaggcgaaa ttattcgtgg ggttaaagga aaggatttgc 83040 ttcaaaataa tatagactat attaatagaa gtcgatcata ttatgtaatg aaaattaaat 83100 ccaatttacc ttcttcccgc tggaaatctg acgttattcg ttttgttcat ccagtaggat 83160 ttggatttat agcaattacc cttttaacta tgtttattaa tgttggttta actcttaaac 83220 atacagagac cataattaat aaatacaaaa actacaaatg ggattctgga ttgcctactg 83280 aatatgctga tagagtagct aaattgactc cgactggtga aattgagcat gattcggtaa 83340 caggcgaagc aatttatgaa cctggcccaa tggctggcgt agaatatcct cttcctgatg 83400 actataatac tgaaaataac aattcaatat ttcaaggtca attgccgtct gaacgacgca 83460 aattaatgag tcctctattt gatgcatctg gaacaacatt tgcacaattt agggatttag 83520 ttaataaacg tctaaaagat aatataggaa atccaagaga ccctgaaaat ccaacacagg 83580 ttaaaataga tgaatgattc aagtgttatc tatcgtgcga tagttacttc aaaatttaga 83640 acagaaaaaa tgttgaattt ttataattca attggaagtg gtccggataa aaacactatc 83700 tttatcacat ttggaagatc agaaccgtgg tcatcaaatg aaaatgaggt gggctttgct 83760 ccaccttatc caactgattc tgtattgggt gtaactgaca tgtggactca tatgatggga 83820 actgtaaagg ttcttccatc tatgcttgat gcagttattc ctcgtagaga ttggggagat 83880 actagatatc cggatccata cacatttaga attaacgata ttgtagtgtg taactcagct 83940 ccttacaatg ctactgaatc aggcgcaggc tggttagtat atcgttgttt agatgttcct 84000 gataccggaa cgtgttcaat agcatcttta actaataagg atgaatgtct taagttaggt 84060 ggaaaatgga ctccttctgt taggtcaatg actcctcctg aaggtcgagg agacgctgaa 84120 ggaacaatcg aacccggcga cggttatgtt tgggaatatc tttttgagat tccgcctgat 84180 gtatctataa atagatgcac gaatgaatat atcgtagttc cttggcctga ggaattaaaa 84240 gaagaccctg ctagatgggg gtatgaagat aatctcactt ggcaacaaga tgattttgga 84300 ttaatttacc gtgttaaggc aaatactatc cgttttaaag catatttaga ttcagtttac 84360 tttcctgatg ctgcattacc gggaaataaa ggatttagac aaatatcaat aatcaccaat 84420 cctcttgaag ctaaagttca tccaaatgac ccaaacgtta aagctgaaaa ggattattat 84480 gatccggaag atttaatgag gcattcgggc gaaatgattt atatggaaaa taggccacct 84540 attatcatgg caatggatca aacagaagaa atcaatattc tgtttacatt ttaaattaag 84600 ggagcccatg ggctcccttt ttctttataa atactataaa ctcataagga aaccgctatg 84660 ttcattcaag aaccaaagaa attgattgat accggcgaaa ttggtaacgc ttctactggt 84720 gatatcttat tcgacggtgg taataaaatt aatagtgatt ttaacgcaat ttataatgcg 84780 tttggcgatc agcgcaaaat ggcagtagca aatggcactg gagcagatgg ccaaattatt 84840 catgctactg gatattatca aaaacactct attgcagagt acgcaactcc agtaaaagtt 84900 ggcactaggc atgatattga tacctctact gtaggtgtta aagttatcat tgaaagaggc 84960 gaacttggtg actgcgttga atttattaac tcaaatggat ctatatcagt tactaatcct 85020 ttaacgattc aagcaattga ttcaattaaa ggtgtttcag gcaatttagt agtaactagc 85080 ccatatagta aagtaacttt acgctgtatt tcatctgata attctacatc ggtttggaat 85140 tattctattg aaagtatgtt tggacaaaag gaatcaccag ctgaaggtac atggaatatt 85200 tctacatccg gatcagttga tattccatta tttcatcgta ctgaatacaa tatggctaaa 85260 ttgctagtta catgccagtc agtagatgga agaaaaatta aaacagcaga aataaatatt 85320 cttgtggata ctgttaattc agaggtcatt tcttctgaat atgctgtcat gcgagttggg 85380 aatgaaaccg aagaagacga aatcgctaat attgcattta gtgttaaaga aaattatgta 85440 acggcgacta taagttcttc aactgtcggt atgagagcag cagttaaagt tatcgctacg 85500 cagaaaatcg gggtggctca ataatgaaac aaaatattaa tatcggtaat gttgtagatg 85560 atggtaccgg tgactacctg cgtaaaggtg gtataaaaat aaatgaaaac tttgatgagc 85620 tttattatga actcggtgat ggtaatgttc catattcagc cggtgcttgg aaaacttata 85680 atgcttcatc tgggcaaaca ttaaaagctg aatggggaaa atcatacgct attaatactt 85740 cgtctggaag agtaacactg caacttccta aaggaactgt taatgattat aataaagtaa 85800 ttagagctag ggatgtattt gcaacatgga atgttaatcc agttacttta gtagccgctt 85860 ctggtgatac tatcaaagga tcatcgtcat cggttgaaat taacgttcaa tttagtgatt 85920 tagagctagt ttattgcgct ccgggccgtt gggaatatgt caaaaataaa caaattgaca 85980 aaattattag ttcagacatt agcaatgtag ctcgtaaaga atttttagtc gaagttcaag 86040 gacaaacaga ctttttagat attttccgtg gaactagtta taatgttaat aacatcagag 86100 taaaacaccg cggtaatgaa ttgtattacg gcgatgtttt tagcgaaaat agcgactttg 86160 gttctcctgg agaaaatgaa ggcgaattag ttcctcttga tggatttaat attcgattaa 86220 gacagccttg taatattggt gacactgttc aaattgaaac atttatggat ggtgtatcac 86280 aatggagaag ttcatataca agacgccaaa taaaagtact ggattcaaaa ctaacatcaa 86340 agacttcttt agaaggaagt atttacgtta ctgatttatc gacgatgaaa tcaattccat 86400 tttccgcatt tggattaatt ccaggagaac ctattaatcc taattctctt gaagttcgtt 86460 ttaatggaat tttacaacaa caagctggaa cagctggata tcctctgttt ttgtgtgaag 86520 gcgctagttc agatacgcaa gaaggatgta tatctcttgg tggtgaatgg aaagaatcaa 86580 acacagatta ttctatagaa tatgaagatg gaaaacctac cagtctttta tttgatagaa 86640 aatttgaatc aggcgatata atcgttataa cgtggttcaa taatgattta ggaactcttt 86700 tagaaaaaga tgacatcatt gaattgactg atgaccgtta tgttagcaaa ggatcatcta 86760 ccgaagttac tggtgatgta gccttaacag attttgataa aatcggttgg ccaaatgttg 86820 aaaaagttga ttcttatact agaacgtata attcaatatc atctattttc gatagcattt 86880 atcctgtagg ttcaatttat gaaaatgcta taaacccaaa taatccagta acttatatgg 86940 gatttggttc atggaaatta tttggtaaag ggcaggtttt agtaggatgg aatgatgatg 87000 tcacagatcc aaactttgca ttaaacaata atgatttaga ttctagcgga aatccttcac 87060 ataccgccgg tggaacagtt ggtacaacat cagtaacgct tgaaaacgca aatcttcctg 87120 cgactaaaac tgatgaaaga gttttaattg aagacgaaaa tggatcagtt attattggag 87180 gatgtcaata tgacccagac gaaactggtc ctatatatac aaaatatcgt gaagactacg 87240 caacaacaaa ctcttcacat actcctcctg ctaatattag taatattcaa ccgtctatta 87300 ctgtataccg ttggataagg attgcataat gagtttactt aataataaag cgggagttat 87360 ttcccgctta gcagattttc ttggttttag aactaagaaa aatgatattt cggttatgaa 87420 taatcagcca gtaggtgctg taacaatttc acaaatagca aaaggttttt atgacccaaa 87480 tgtagaatct gctatcaatg atgttagaaa tatggcagag caacaggttg gagctgtatt 87540 agttaatata agtggcgtat ctcctactgg cgtgcagcaa acagactatt ggtcatttga 87600 aggaactgtt actgatactt cagccaaacc aggtgacaca gttattgtta atatgtttgg 87660 cattcctgtt aaagctacta atggaatgac ttcaatcgaa tttaccagtg ccgttagaac 87720 agctctgcag gaaatggttg caaaatttat tgcaattgat tcatttgaag accatcctac 87780 cataggaaat aaaatacaag ttaagtattt agataaccaa gaacatatct tagaacaata 87840 ctctgataaa ggaattactt tcaaacaaga aataatttct ccttctaaac ctggatacgg 87900 aacttggcaa ttattaggtg cgcaaactgt cacgctagat agtcacacac aacctacggt 87960 attttattat tttgagagaa tagcatgagt aacaatacat atcagcacgt atcaaatgaa 88020 tcaaaatatg ttaaattcga tccagtagga tcgaattttc ctgacactgt cacgacagtg 88080 cagtctgcat tatcaaaaat aagtaatatc ggcgtaaatg gtattcctga tgcaactatg 88140 gaagttaaag gaatagcaat gattgcgtca gagcaagagg ttttagatgg aactaataat 88200 tctaaaatcg ttacaccagc tacattagca acaagattat tgtatccaaa tgctactgaa 88260 actaagtatg gtttaacgcg ctattcaaca aatgaagaaa cattagaagg ctcagataat 88320 aattcatcaa taacgccgca aaaactgaaa taccatactg acgatgtgtt ccaaaataga 88380 tattcgtctg agtcatcaaa cggggttatt aaaatatcat ctacacctgc agctttagct 88440 ggagttgatg atactacggc aatgactcca ttaaaaacgc aaaaacttgc aataaaatta 88500 atttcacaaa tagctccttc cgaagatact gcatcagaat ctgtgagagg tgtagttcaa 88560 ttatctactg ttgcgcaaac tcgtcaagga actctccgcg aaggatatgc aatttctccg 88620 tataccttta tgaattctgt tgcaacacaa gaatataagg gtgttatacg tttaggaaca 88680 caatcggaaa ttaacagtaa tttgggagat gttgcagtaa cgggtgaaac gctaaatggt 88740 cgaggagcta ctggttctat gcgtggagta gttaaattaa cgacgcaagc cggtattgcc 88800 cctgaaggtg atagctctgg tgcattagca tggaacgcag atgtaattaa tactcgtggt 88860 ggacaaacta ttaatggttc tttaaattta gaccatctta cagcaaacgg aatttggtcg 88920 cgcggcggaa tgtggaaaaa tggcgatcaa cctgttgcca ctgaaagata cgcgtccgaa 88980 agggttccag ttggaactat tatgatgttt gctggagatt cagcacctcc gggttggatt 89040 atgtgccacg gcggaaccgt gtcaggagat caatatcctg attatagaaa cacagttgga 89100 acgagatttg gtggcgattg gaataatcct ggcattcctg atatgcgagg tctttttgtt 89160 agaggagcgg gcaccggcgg tcatatttta aatcaacgag gacaagatgg ttatgggaag 89220 gatagacttg gtgtaggatg tgatggaatg catgttggtg gtgttcaagc acaacaaata 89280 tcataccata aacatgctgg tgcctggggg gaaaatggaa ataacagagg ttatgcaccg 89340 tttggcgcat ctaatggcaa tggatatttg ggcaatggta aaagcgccga ctgggacaac 89400 catttgttct ttactaatga cggatttgaa atgggtggtc ctcgtgactc gtttggcacg 89460 ttaaatcgcg aaggattaat tggttatgaa actagaccat ggaatatatc attaaactat 89520 attattaaaa ttcattacta aggattacaa atgattgaat taaaagagtt accttttgtt 89580 gatagcgttc ctggcgaagg tcaggaacgt atttcatgga ttaaaaatgg tgaagaaata 89640 ctaggagcta gtactaagta tggaaacgat ggatcaatga atagaccaac tgtttccgtg 89700 tttaaaaacg tcgaagttct tgatgaaaat gtgggaattc ttaaaactgc tgttgaaaca 89760 tcacaggaag atattaaaac aattcaaggc attttagatg tatcaggaga tatagaagcg 89820 ctatcacaaa tcagcgttaa taaaaatgac atatcaaatt taaaaacgct tacgagtgaa 89880 catactgata tattaaatgg tacaaatact acggttgata atattctttc tgatattggt 89940 ccatttaatt cgcaagcaaa ttcagtttat agaacgatta gaaatgattt gttatggatt 90000 aaaagggaat taggacaata tgctgggcaa gatattaatg gtcttcctgt tgtaggaaat 90060 agcagcacgg ggatgaagca ccgtatcatt aataatacag atgctataac ttcccaagga 90120 atacgtctaa gtgatttgga agaaaaattt attgaatctg atgtaggttc actgacaatt 90180 gaagtcggaa atcttagaca agaacttgga caaagaccat cttcatttag tgaaagcata 90240 tattcacgtg tgcataattt agatcaatca cagattaatc ttagttccga aattaaatct 90300 atcaaaactt ctattggata tccaggaaat acttcaataa tcacagatgt caatgtcaac 90360 agtcaagaaa tttcagcttt aaatgatgaa ctaaataaaa gtggcggcgt taaacagcga 90420 ttaactgtta ttgaaacatc gattggttca gatgatattc cttctagtat taaaggtcaa 90480 attaaagata ataccacttc tattgaatct ttaaatggaa ttgtaggtga aaacacctcg 90540 tccggtttaa gagctaacgt ttcatggcta aatcagatag ttggaactga ttctagcgga 90600 ggtcaacctt ctcctccggg gtctctttta aatagagttt caactgttga aacctctgtt 90660 aatagactta acaatgatgt tcaaaactta caggttgaaa ttggtaataa cagttccgga 90720 attaaagggc aagttgtaac actaaataaa ttagtaagtg gaacaaatcc gaatggttca 90780 actgtcgaag aacgcggatt gactaattca ataaaagcta atgagactaa catttcttca 90840 attaatcaag agattcgtag tattaaaggt aatgtgtcct cattgcagag ggatgtccag 90900 actttacaag aagctggtta tattcctgaa gctccaaaag atggtcaagc ttacgttcgt 90960 aaagacggcg aatgggtatt gctttctacc tttttatcac cagcataaca tggggccgca 91020 aggccctaaa ggattttaaa tgtcaggata taattctcag aatccaaagg aactcaaaga 91080 tgtcattcta agacgtttag gggctccaat tattaatgtt gagttaacac ccgatcaaat 91140 ttatgattgt atccagcgtg ccctagaatt atacggtgaa taccattttg atggacttaa 91200 caaaggtttt catgtatttt atgtaggaga tgatgaagaa aagtataaga ctggagtatt 91260 tgatttaaga ggttctaacg tatttgcagt aactcgcatt ttgcgcacga atattggatc 91320 aataacgtca atggacggaa acgctacata tccatggttt actgactttc ttttaggaat 91380 ggctggtatt aatggtggca tgggaacttc ttgtaataga ttttatggac caaatgcctt 91440 tggagctgat ttaggatatt ttacccagct taccagttac atgggaatga tgcaagatat 91500 gctttcgcct attccagact tttggtttaa ttcagcaaat gaacaactca aagtcatggg 91560 aaacttccaa aaatatgatt tgattatcgt agaaagctgg actaaatcat acattgatac 91620 aaacaaaatg gttggaaata cagtaggata tggaacagtc ggtccacaag atagctggtc 91680 attatctgaa cgatataata atccagaccg caatttagta ggccgtgttg ttggtcaaga 91740 tccagatgtt aagcaaggtg cttataataa tcgttgggtg aaagactatg caacagcttt 91800 agctaaagaa ttgaatggtc aaattttagc acgtcaccaa ggaatgatgc ttcccggcgg 91860 cgttacaatt gatggtcaac gtttaataga agaagctcgt ttagaaaaag aagcactgcg 91920 cgaagaatta tacttacttg accctccatt tggaattttt gtaggttaat atggctactt 91980 acgataaaaa tctctttgct aaattggaaa accgcacagg ttattctcag accaatgaaa 92040 cagaaatact aaatccttat gtaaatttta accactatca aaacagccaa atactagctg 92100 atgtattagt agctgaaagc attcaaatgc gaggtgtaga atgctattat gttccaagag 92160 agtatgtttc ccctgatttg gtattcggcg aagacctaaa aaataaattt actaaagcat 92220 ggaaatttgc tgcatattta aattcatttg aaggatatga aggagctaaa tcgttctttg 92280 gtaactttgg tatgcaagta caggatgaag taactttgtc cattaatcca aacctgttta 92340 aacatcaagt aaatggaaaa gaacccaagg aaggtgattt gatatatttt cctatggata 92400 acagcttatt tgaaatcaac tgggttgaac catatgaccc attttatcaa ttaggccaaa 92460 acgctattcg taaaattaca gcaggtaaat tcatttattc tggagaagaa attaatccgg 92520 ttctacagaa aaatgaagga attaacattc cagaattcag tgaattagaa ttaaatcctg 92580 ttcgtaatct taatggcatt catgatatta atattgatca gtatgctgaa gtagatcaaa 92640 ttaattctga agctaaagaa tatgttgaac cttatgttgt tgtcaataac agaggaaaat 92700 ctttcgaatc tagcccattt gataatgatt tcatggatta ataaatacta taaattaatt 92760 aaagcccaga ttaggagaaa tcatgtttgg ttatttttat aattcgtctt ttagacgata 92820 tgctaccttg atgggcgatt tgttttcaaa tatccaaatc aaacgtcagt tagaatctgg 92880 tgataagttt atacgtgttc ctattacgta tgcatcaaag gaacacttca tgatgaaatt 92940 aaataaatgg acatcgataa attcgcaaga agatgtagct aaagttgaaa ctattctacc 93000 tcgtataaat ttacatttag ttgattttag ctataatgct ccatttaaaa caaacatttt 93060 aaatcagaat ttactgcaaa aaggcgcaac ttctgtagta tcacagtata atccatctcc 93120 tattaaaatg atttatgaat tgagtatctt tactcgatac gaagacgata tgtttcaaat 93180 agttgaacag attcttccat attttcaacc tcattttaat acaactatgt acgaacagtt 93240 tggaaatgat attccattta aaagggatat taaaattgta ctgatgtctg ctgctataga 93300 tgaagctata gatggagata atttatctcg tcgtagaatt gaatggtcac taacatttga 93360 agtaaatggg tggatgtatc ctccagtaga tgatgcagaa ggattaattc gtactactta 93420 tacagatttt cacgccaata caagagattt gcctgatggc gaaggtgttt ttgaatctgt 93480 cgatagcgaa gttgttcctc gagatattaa cccagaagac tgggatggaa cagtaaaaca 93540 aactttcacc agcaatgtaa atagaccaac accgccagaa cctcctggcc caagaacata 93600 gaggttatta tggaaggtct tgatataaac aaacttttag atatttctga cctccccgga 93660 attgacgggg aggaaattaa agtatatgaa cctctgcaat tagtagaagt taaaagcaat 93720 cctcaaaacc gtactcctga cttagaagat gattatggag tagttcgtcg aaatatgcat 93780 tttcaacaac aaatgctaat ggacgcagcc aagatttttc ttgagacggc aaagaatgct 93840 gattctcctc gtcacatgga agtatttgca actcttatgg ggcaaatgac tacgacgaac 93900 agagaaatac tgaagcttca caaagatatg aaagatatta catctgaaca ggttggcacc 93960 aaaggcgctg ttcctacagg tcaaatgaat attcagaatg cgacagtatt catgggttca 94020 ccaacagaat taatggacga aattggtgat gcttacgagg ctcaagaagc tcgtgagaag 94080 gtgataaatg gaacaaccga ttaatgcatt aaatgatttc caccctttaa atgaagctgg 94140 aaaaatttta ataaaacacc caagcttagc agaaagaaaa gatgaagatg gaattcattg 94200 gataaaatca cagtgggatg gaaaatggta tcctgaaaaa ttcagcgatt atcttcgttt 94260 acacaaaata gtaaaaatcc caaataattc tgataagcct gaattatttc aaacttataa 94320 agataagaat aataaaagat ctcggtatat gggtcttcct aacttaaaac gagctaatat 94380 taaaacacaa tggactcgtg aaatggttga ggaatggaaa aaatgccgag acgatattgt 94440 ttattttgcg gaaacatact gcgctattac tcatattgac tatggtgtca taaaggttca 94500 attacgtgac taccaacgtg atatgctcaa aataatgtca tctaaacgta tgactgtttg 94560 taatttatca cgtcagcttg gtaaaacaac tgtagtagct atttttcttg cacactttgt 94620 atgctttaac aaggataaag ctgtaggtat tcttgcgcac aaaggctcaa tgtctgcaga 94680 agttttagat cgtactaagc aagcaattga actgcttcct gactttttac aacccggaat 94740 tgttgaatgg aataaagggt ctattgaact tgataatggt tcctcaatcg gagcctatgc 94800 ttcctctcct gacgcagttc gtggtaactc gttcgcaatg atttatattg acgaatgcgc 94860 gtttattcca aacttccatg attcctggct tgctattcaa ccggtaattt catctggtcg 94920 tcgttcgaaa attattatta ctacgactcc taatggatta aatcattttt atgatatttg 94980 gactgctgct gttgaaggta aatcagggtt tgaaccatac actgctattt ggaattcagt 95040 taaagagcgt ctttataacg atgaagatat ttttgacgat ggatggcaat ggagcataca 95100 aaccattaat ggttctactt tagctcaatt tcgtcaagaa cacaccgcag cgtttgaagg 95160 gacttctggt acattaattt caggaatgaa attagctgtt atggatttca tcgaagtaac 95220 accagatgat cacggttttc atcgatttaa aagctctgaa ccagatagaa aatatattgc 95280 aactttagac tgctcagaag gtcgtggaca agattatcat gctttacata ttattgatgt 95340 cacagatgat gtgtgggaac aagttggggt tttacattca aacacaattt ctcatttaat 95400 tctacctgac atcgttatgc gttatttagt agaatataat gaatgcccag tttatattga 95460 attaaatagt actggtgtgt cagttgcgaa atcgctttat atggatttag aatacgaagg 95520 cgttatttgc gattcatata ctgatttagg aatgaagcaa actaaacgaa cgaaagcagt 95580 aggatgctct acattaaaag accttattga aaaagataag cttattattc atcaccgcgc 95640 aactattcag gagtttagaa cgtttagtga aaaaggcgtg tcttgggcgg ctgaagaagg 95700 ttatcatgat gatttagtaa tgtctttagt gatttttgga tggttatcaa cacaatcaaa 95760 atttattgat tatgctgaca aagatgacat gcgattagca tctgaagtgt tttcaaaaga 95820 acttcaagat atgggtgatg aatacgctcc agttatattt gttgattcgg ttcattctgc 95880 tgagtatgtt ccagtatctc atggtatgtc aatggtataa atatattaaa gcatattaaa 95940 gaggattaaa aatgacttta ttatctccgg gcattgagct caaagaaact acggttcaaa 96000 gcaccgtggt taataactct actggtacag cagctttggc cggtaaattc cagtggggtc 96060 ctgcttttca gatcaaacag gttacaaatg aagtagattt agttaatact tttggtcaac 96120 ctacagctga aactgctgat tattttatgt ctgcaatgaa tttcttacaa tatggaaatg 96180 atttgcgagt tgtgcgtgct gtcgatagag ataccgctaa aaactcatct ccgattgccg 96240 gtaatattga atacactatt tctaccccag gtagtaacta cgcggttgga gataaaatca 96300 cggttaagta tgtttcagaa gatgttgaaa cagaatgtaa agttaccgaa gtagatgctg 96360 atggaaaaat taagaaaatt aatattccta ccgcaaaaat tatcgctaaa gcgaaagaag 96420 taggcgaata tccagcatta ggttctaact ggaccgcgga aatttcttcg tcttcctctg 96480 gtttagctgc agtaataact cttggaaaaa ttattactga ttctggtatt ttattagctg 96540 aaattgaaaa tgctgaagct gctatgacag ctgttgactt tcaagcaaat ctcgaaaaat 96600 atggaattcc aggagtagta gctctttatc caggcgagtt gggcgataaa atcgaaattg 96660 aaatcgtatc taaagctgac tacgcaaaag gtgcttctgc attacttcca atttatccag 96720 gtggcggaac acgcgcatct actgccaaag cagtgtttgg atatggacca caaactgatt 96780 cacaatacgc tattatagtt cgtcgcaatg atgctattgt tcaaagcgtt gttctttcga 96840 caaagcgagg tgaaaaagat atttacgata gtaacatcta tattgacgac tttttcgcaa 96900 aaggtggttc agaatatatt ttcgcaactg cacaaaactg gccagaaggc ttctctggaa 96960 ttttaactct gtctggtgga ttatcatcaa atgctgaagt aacagcagga gatttgatgg 97020 aagcttgggg cttctttgct gaccgtgaat ctgttgatgt tcagttgttt attgcgggtt 97080 cttgtgccgg tgaatcttta gaaacagcat ctactgtcca aaaacacgtc gtttcaattg 97140 gggatgctcg ccaagattgc ttagtactgt gctcgccacc gcgtgaaact gtagttggaa 97200 ttcctgtaac tcgtgctgtt gataacttag tcaattggag aactgccgca ggttcatata 97260 ctgataataa ctttaatatt agttcaacct acgcagcaat tgatggtaac tacaagtatc 97320 agtatgacaa atataatgat gtaaatcgtt gggttccatt agcagctgat attgccggat 97380 tgtgcgcaag aactgacaac gtatctcaga cttggatgtc tccagctggt tataatcgtg 97440 gccagattct taacgttatt aaacttgcta ttgaaactcg ccaggctcag cgcgaccgtt 97500 tataccaaga agctatcaac ccggtaactg gtacaggtgg tgatggttac gtattatatg 97560 gtgataaaac agctacttct gttccttctc catttgatcg tattaacgtt cgtcgtctgt 97620 ttaatatgtt gaaaacgaat atcggacgta gttcaaaata tcgtttgttc gaattaaaca 97680 acgcgtttac tcgttcatca ttccgcacag aaactgccca gtacttacag ggaattaaag 97740 ctctcggtgg aatttatgaa tatcgtgtag tttgcgatac aacaaataac actccgtcag 97800 taattgatag aaatgagttt gttgcaacat tctacattca accggcgcgc agtataaatt 97860 atattacttt gaatttcgtc gcaactgcta ctggtgcaga tttcgatgag ttaactggtc 97920 ttgcaggtta atacggtgca ttctaaaggc ctgtttcggc aggccatata aatacactat 97980 atccttaatt ctttaattct atatgcccta ggttaaacat agggatataa atactacaga 98040 ggctaatatg tttgtagatg atgtaacacg agcgtttgaa tctggtgatt ttgctcgacc 98100 taacttattc caagtagaaa tttcttatct tggacaaaat tttacgtttc aatgcaaagc 98160 cactgcttta ccagctggta ttgtagaaaa aattccagtc ggatttatga accgtaaaat 98220 taacgtagca ggcgatcgta cattcgatga ctggactgtt acagtaatga acgatgaggc 98280 acatgatgct cgccagaagt ttgttgattg gcaaagcatt gctgctgggc aagggaacga 98340 aattactggt ggaaaaccag cagagtataa aaagagcgct gttgttcgcc aatacgctcg 98400 tgatgctaaa acagtaacaa aagaaattga aattaaaggt ctatggccta ctaacgttgg 98460 tgaacttcaa ttagattggg attcaaacaa tgaaatccaa acatttgaag taactcttgc 98520 tctcgattat tgggaataaa atgaatgggg agaaatcccc atcctgcttt aagcagagaa 98580 gtccattata aatataacta taattcccat ttggagaata caatgaaatt taatgtatta 98640 agtttgtttg ctccatgggc taaaatggac gaacgaaatt ttaaagacca agaaaaagaa 98700 gatcttgttt ccattacagc cccaaagctt gatgatggag caagagaatt tgaagtaagc 98760 tcgaatgaag ctgcttctcc ttataatgct gcattccaaa caatttttgg ttcatatgaa 98820 ccgggaatga aaaccactcg tgagcttatt gatacatatc gtaatctcat gaataactat 98880 gaagtagata atgcagtttc agaaatcgtt tcagatgcta tcgtctacga agatgatact 98940 gaagtcgtag cgttaaattt ggataaatct aaatttagcc caaaaattaa aaatatgatg 99000 ttagatgaat ttagtgatgt attaaatcat ctatcgtttc aacgaaaagg ttctgatcat 99060 tttagacgtt ggtatgtcga ttcaagaatt ttcttccata aaatcattga tccaaaacgt 99120 ccaaaagaag gcataaaaga attacgtaga ttagaccctc gccaagttca gtatgttcgt 99180 gaaattataa ccgaaactga agctggcaca aaaatagtta aaggttacaa agagtatttt 99240 atatatgata ctgcccatga gtcatatgcg tgtgatggta gaatgtatga agctggcaca 99300 aaaataaaaa ttcctaaagc tgctgtcgtt tatgcccatt ctggattagt cgattgttgt 99360 ggtaaaaata tcatcgggta tttacatcgt gctgttaaac ctgctaacca attaaaatta 99420 ttagaagatg ctgtagtcat ttatcgcatt actcgtgctc ctgaccgtcg tgtttggtat 99480 gtagacacag gtaatatgcc tgctcgtaaa gctgccgagc acatgcaaca tgtcatgaac 99540 acgatgaaaa accgtgtagt atatgacgca tcgaccggta aaataaaaaa tcaacagcat 99600 aatatgtcta tgaccgaaga ctattggtta cagcgccgcg atggtaaagc tgtgacagaa 99660 gttgatactc ttcctggtgc cgataatact ggtaatatgg aagatgttcg ttggtttaga 99720 caagctcttt atatggcatt acgtgttcct ctttcacgca tcccgcaaga ccaacaaggc 99780 ggtgtgatgt ttgattctgg aactagcatt acacgtgatg aattaacgtt tgctaaattt 99840 attcgtgagt tacagcataa gtttgaagaa gttttcctgg atccgcttaa aacaaatctg 99900 ttgcttaaag gtataatcac agaagatgag tggaatgatg aaataaataa tattaagata 99960 gaatttcatc gggatagcta ctttactgaa ctcaaagaag cagaaatttt ggaacgaaga 100020 attaatatgc taaccatggc agaaccattt attggtaaat atatttctca cagaactgct 100080 atgaaagata ttttgcagat gactgatgaa gaaatagaac aagaagccaa gcaaattgaa 100140 gaagagtcta aagaggctcg tttccaagac cccgaccaag aacaagagga tttttaatgg 100200 aaggtttaat tgaagctatt aaatcaaacg acctcgtagc cgctcgtaaa ttctttgctg 100260 aagccatggc tgcaagaacg attgatttaa ttaaagaaga aaaaatcgct atcgctcgta 100320 atttcttaat cgaaggtgaa gaacctgatg atgaggatga cgaagacgag gatgatgacg 100380 aagatagcga tgataaagac gacaaaaaag gcaaagactc tgacgaagat gacgaagacg 100440 aggatgatga ataatgcttc tgatccctga aactcatgaa ttagttctcg agaatgtcga 100500 agcacttatt cctgaagcac agggtcgctt tgacgaattg tcttctgctt taaataaaga 100560 cgatataaat acaattgtcg agaatatgct tgatgatgaa actgatttag cgattgcatt 100620 agcttctatt aatgaagata tgccgctaaa tgaattcatc gttaaacatg tttctgctcg 100680 tggtgaaatt acacgtacta aagaccgcaa gacgcgtgaa cgtaatgcat ttcaaaccac 100740 cgggctgtct aaagcaaaac gtagacaaat tgctcgcaaa gctaccaaaa cgaagattgc 100800 caacccagca ggtcaatctc gtgctcagcg taagcgtaaa aaagctctta aacgccgtaa 100860 agcattagga ttaagctaat gaatgaaccc caattactaa ttgaaacttg gggtcaacct 100920 ggcgaaatta ttgatggcgt gccaatgctt gaatcccatg atggaaaaga cttaggttta 100980 aaacctggtt tatacatcga aggaatattc atgcaagcag aagtcgtcaa tagaaataaa 101040 cgtctttatc caaaacgtat attagaaaaa gcggtaaaag actatattaa tgagcaagtt 101100 ttaactaaac aagctctcgg agaattaaat catcctccac gcgctaatgt tgacccgatg 101160 caagccgcta tcattataga agatatgtgg tggaaaggaa atgacgtata cggacgagct 101220 cgtgttattg aaggtgacca tggtcctgga gataaattag cagctaatat tcgtgccgga 101280 tggattccag gagtttcttc tcgtggatta ggttcattga ctgacacaaa taaaggttat 101340 cgtatcgtaa acgaaggatt caaattaact gtaggtgttg atgcagtatg gggtccaagt 101400 gctccagatg catgggtaac tcctaaggaa attaccgaat cacagacggc ggaagccgat 101460 acaagtgccg atgacgccta tatggctctc gcagaggcca tgaaaaaagc gttataaata 101520 ttattatcta aacaacagga ctacaaaatg cttaaagaac aactgattgc tgaagcgcaa 101580 aaaattgatg cttccgttgc tcttgatagt attttcgaat cagttaatat ttctccggaa 101640 gcaaaagaaa ctttcggcac tgtattcgaa gctaccgtca agcagcacgc cgttaaatta 101700 gctgaatctc atatcgctaa aattgctgaa aaagcagaag aagaagtaga aaaaaataaa 101760 gaagaagccg aagaaaaagc tgagaagaaa attgctgagc aagcttctaa attcatcgac 101820 catcttgcaa aagaatggct cgctgaaaat aaattagcag ttgataaagg catcaaagcc 101880 gaactgtttg aatccatgct aggtggatta aaagagctct ttgttgaaca caacgtcgtt 101940 gttccagaag aatcagttga tgttgtagct gaaatggaag aagagctgca agaacataaa 102000 gaagaatcag ctcgtctgtt cgaagaactc aatatgcgcg acgcatatat caattatgtg 102060 cagcgtgaag tggcattgag cgaaagtact aaagatctga ctgagtctca aaaagaaaaa 102120 gtctctgctc tggtcgaagg tatggattat tcagatgcat tctcaagtaa attgagtgcc 102180 atcgtagaaa tggtgaagaa gtctaataaa gatgaaagca ctattactga gggtataaat 102240 actcctgata ctgaagcagc cggactgaat ttcgtcactg aagctgtaga agataaaact 102300 gcacctggtg cagaagatat tgtaagtgta tatgcgaaag tcgcatctcg tttctaattt 102360 taaaggttaa cacaaatgac tatcaaaact aaagctgaac ttttgaacaa atggaagcca 102420 ttactggaag gtgaaggttt accggaaatt gctaatagca aacaagcgat tatcgctaaa 102480 atctttgaaa accaggaaaa agatttccag acagctccag agtacaaaga cgaaaaaatc 102540 gctcaggcgt tcggttcttt cttaacagaa gctgaaatcg gtggtgacca cggttacaac 102600 gctactaaca tcgctgctgg tcagacttct ggcgcagtaa ctcagattgg cccagctgtt 102660 atgggtatgg tacgtcgtgc tattcctaac ctgattgctt tcgatatttg tggtgttcag 102720 ccgatgaaca gcccgactgg ccaggtattc gcactgcgtg cagtatatgg taaagaccca 102780 atcgctgccg gtgctaaaga agcattccac ccaatgtatg gtccagatgc aatgttctct 102840 ggtcagggtg ctgctaagaa attcccagct ctggctgcta gcacacaaac cacagtaggt 102900 gatatctata ctcacttctt ccaggacact ggtactgtgt atctgcaggc ttctgctcaa 102960 gtaacaatta gttctactgc agatgatgca gctaaattag atgctgaaat taagaaacaa 103020 atggaagctg gcgtactggt agaaattgct gaaggtatgg ctacttctat cgctgaactc 103080 caggaaggtt tcaacggttc taccgataac ccatggaatg aaatgggctt ccgtatcgat 103140 aaacaagtta tcgaagctaa atctcgccag ctgaaagctg cttactctat cgaattagca 103200 caagacctcc gcgctgttca cggtatggat gctgatgctg aactgtctgg tattctggct 103260 accgaaatca tgttggaaat caaccgtgaa gttgttgatt ggattaacta ctcagctcag 103320 gttggtaaat ctggtatgac cctgactcct ggttctaaag ctggtgtatt tgacttccag 103380 gatccgattg atattcgtgg tgctcgctgg gcgggtgaat cctttaaagc tctgttgttc 103440 cagattgaca aagaagcagt tgaaattgct cgtcagaccg gtcgtggtga aggtaacttc 103500 attatcgctt cccgtaacgt agttaacgtt ctggcttcag ttgatactgg catttcttat 103560 gctgcacagg gtctggctac cggctttaac actgatacta ccaagtcagt atttgctggt 103620 gttctgggtg gtaaataccg tgtatatatc gaccagtatg ctaaacagga ttatttcact 103680 gtaggttata aaggtccgaa cgaaatggat gctggtattt actatgctcc atatgtagct 103740 ctgactccgc tgcgtggttc cgatccgaag aacttccaac cagtaatggg attcaaaact 103800 cgttacggta tcggtatcaa cccatttgca gaatccgctg ctcaggctcc ggcttctcgc 103860 atccagagcg gtatgccttc tattctgaat agccttggta aaaacgctta cttccgccgt 103920 gtatatgtta aaggtatcta atctttgacg atttaaggga ccttcgggtc cctttagttg 103980 tttttatggt ataaataaat catataaacc aaaaggaaag cgcaatggct aaaatcaacg 104040 aacttctgcg cgaatcaacc acaacgaata gcaactcaat cggtcgccca aatctcgttg 104100 ctttgactcg cgctaccact aaattaatat attctgacat tgtagcaacg caaagaacta 104160 atcaacctgt tgctgctttt tatggtatca aataccttaa cccagacaac gaatttacat 104220 ttaaaactgg tgctacttac gctggcgaag ctggatatgt agaccgagaa caaatcacag 104280 aattaacaga agagtctaaa ttaactctca ataaaggcga tttattcaaa tataataata 104340 tcgtttataa agtattagaa gatactccat tcgctgatat tgaagaaagc gacttagagt 104400 tagctcttca gattgcaatt gttcttttaa aggttcgtct attttctgac gcagcgtcaa 104460 caagcaaatt tgaaagctct gatagtgaaa ttgcggatgc tagatttcag attaataaat 104520 ggcaaaccgc ggttaaatct cgtaaactta aaactggcat cacagttgaa ttagcgcaag 104580 atttagaagc aaatggattc gatgctccta atttcttgga agatttgctt gcaactgaaa 104640 tggcagatga aatcaataaa gatattctgc agtctttgat tacagtgtca aaacgctata 104700 aagttacagg aattactgat agtggattca tcgatttgag ttatgcatct gcacctgaag 104760 cgggtcgttc attatatcga atggtatgtg aaatggtttc gcatatccaa aaagaatcaa 104820 cttatacagc aacgttctgt gttgcttcag ctcgtgccgc tgcgattctt gctgcatcag 104880 gttggttaaa acataaacca gaagatgata aatatctttc acaaaatgcc tacgggttct 104940 tagctaatgg tttaccgctt tattgcgata ctaacagccc attagattat gtaatcgttg 105000 gtgtagtaga aaatatcggt gaaaaagaaa ttgttgggtc aattttctat gctccgtata 105060 cagaaggtct tgacttagat gaccctgaac atgtaggtgc atttaaagtt gtagttgatc 105120 cagaaagttt gcagccatct atcggtttat tagttagata tgctttatct gcaaatcctt 105180 acactgtagc aaaagatgaa aaagaagcaa gagtaattga cggtggagac atggataaaa 105240 tggcgggtcg ttcagatttg tctgttttat taggtgttaa gctaccaaaa attatcattg 105300 atgaataaaa caaagggacc gaaaggtccc tttttattta acttaccaat tcaatccaag 105360 ccggacgaag tacatcttgt accattttaa ctaattcctt cttaatcaaa gaaggattat 105420 ccgcttgagt tagagtaata ccttcacgag aagtttcttc caaaatatct tgaaccgtta 105480 gtcccatcac ctttccaaaa tcctttggac caatttcgcc aattttagaa ataacgttat 105540 ttacgcggtt tagtgtaacg taacaagcta aaattccaac caatttgtta tcagcttctg 105600 atagttcaac tttagcttta ataggcttat cagacttttt cttttcacta aatttagagt 105660 tcttgcattt aatcgctaca cgagcaccgt ttggcagcca tttagggaaa caaggcttca 105720 gaacataacc ttctgcagta ttatcaccaa taacattagc atcaaataca caattatttg 105780 cttcgacaag gtcttccgat gccgtaacgt tataagcggc taagacggaa tcaaggtcgt 105840 ttggaatcat gataagagca tcaaatgttc cacgtccaag cattggtgcc attttaaaac 105900 caaacgtatt acagaaatct tgcatttcgt aatcactcat gtaataagta tcaccgcttt 105960 ccgtgtttat gatgatatcg aatacataga aatctttttc accgtagtca acacctttct 106020 gaattccacc accagcgaat tcaccaaaga cttgatatgt caccggcact gaagttgaaa 106080 tactgtccat gacttcttga acgcctttaa tagctttatc atactttttg agtactattt 106140 catagccata aaaatcttct gctggaagaa taggaccagt acgtttagcg caagttactt 106200 tatcacgctc aataatcaat gagaaatttg taccatgaat cttttcacga gctacccact 106260 ccccaccagt caatcccaag ctataaagtt tttcaatgaa tttagaattg taatgatttt 106320 caagactgct atacttttta aacataatta atcctcaaaa tgtaatttct aaccaatcac 106380 catcacgctg atcactattg actttaaagc taaatccttc ttttctcagc caatcaccaa 106440 tttcttcagt aatcaattta tcgcgagcag tacaataata actaaaatat gttttacctt 106500 gttcagctgc tttattagca agttccgaaa aatctttaat aaaacactct aacttaaact 106560 gtttactttt aagtgctttt tcacgtaatt gattagcaaa agattcattt tcataaagat 106620 catactgttc catttttcac ctttttatta atatgccttt ttctatagac aactttttct 106680 cgagtttcaa atttattctt agcagtcata gctcgagccc ataatacagc cacttccttt 106740 gcctgtaagt tcaattcacg agcaatttca atgaatgact ttccagactc atgaagagta 106800 aacaccacaa cctcagttct cataatcaat ctcatgttat cgagttggtg ccattatata 106860 catcattttc tgagtgtgtt ttgtgtgctt tcaaaatgaa gaaaggggcc gaagcccctt 106920 atgattatgg ataggtatag atgataccag tttctaaagc agttttatga atgatgtatc 106980 cattacgtga ttcttgaaca tcaacttctg gatagtcttt catcatcttc tgaagggtgt 107040 aacgatgcag gtagtattta ctatctggat cttcagtttt ccaatcttta ccttcttcgg 107100 tcattttttg gatttcatcc ataacccacc aaccgcacca gatataagcc gaagtacgat 107160 gtggaagagg atgaacataa ggcaattcac cttctggttc tggagcaact ttatcagtta 107220 cctgaacttg accttctgct gtgatagttt tgctatcata atcagtagca gtaacagttg 107280 cagtaacttc aatagtttga cttccaatag atgatgtatc aacggtgtat acattagttg 107340 acccttctac tggagaagaa tctttcttcc atgaatattc gatttgcgct tcttctggag 107400 catcagtgac attagcagta aatgtagccg aagcatcttg ctgaacgtta atagaaggag 107460 gagtcaatgt aacctgtgga ttcattgttt tcttattaac agtcaatgat acttcattag 107520 aagtaactgt ttttgcgtca taatctgttg ctgttacttg cgctacgcat ttaattcttt 107580 ttactccact tgtagttgga gtatagctaa atgtagcaga agtcgcttca ccaatttgag 107640 aatcatctac ataccattga tatgtagcag acgctccatc gggttgagaa gctaaggcag 107700 cagtaaattg aactggggtt ccaattactc cagcagcggg actattggga gttactgcca 107760 atgtagttgt ctgagttttg tttttgactg tgatagttgt agtagcttct gctatttcag 107820 cttcagattc tggaactgta tttgttgcaa caactttaat agtcttttga ccagcaggac 107880 cttttaatac ataatcaaaa gttgccgctg atccttcttg cggagcatta tctacactcc 107940 aagcataggt aatagttcca cctccagttt caccactggg tgcagcagta aactgcttag 108000 tttcatcaat aactccagta ggtgttttag gagttatatc aactgtaaaa gccataagtt 108060 atccttattt taatgttacg aaagaagaat tgcgtgtttc acgaattaga actgatccgt 108120 cgcgattaat gtaataaatt aagctaaata aagtttggtg cgccgacgcg tgttcaaaac 108180 tagttgggtg agatttccaa tccggagttt cagcaatcca ctggtaaatc caccaaggaa 108240 cggtacagaa tcctggattt tttccaatca gttgaagatt cggactaaag ttttccggaa 108300 gagtaaatac agacggcttt tcagattcaa taatcttatc tacagcttgt tcaaactttt 108360 cttcaacaaa aggagtatct tcaatcaaaa catcggtatt ttcaggaatt ttatccgttt 108420 ctactacttc aattttaatg tcagatttaa ccggagaatc aatcagaagt gctgcctctg 108480 gattgacttc ttcatcgtca tattttaatc cgtctgcagc atcagcagca tcaattaagt 108540 ctttaataga taacccatca gtctctggca taggttcact agcgagcttc tggagggctt 108600 cttcaatatc attaacgata ttatcaaaag atttattctt tttgactttt ataccaaact 108660 gttcagcata ttcagctaat ttagctttag cttctttatt atcatcaaga gccttcagct 108720 ctgcaatata atctttatct atcataatat ttcctcagta taaatataga tatatttatt 108780 actcggaaaa tagtatgtac cactttgtat atgaaacaac aaatctaata aatggtaaaa 108840 agtatatagg aaaacactct actgatgact tgaatgatgg ttaccttggt tccggtaagg 108900 caattcagca ggctataaag aaatatggtg aaaacaattt ctctagaaca atactaaaag 108960 agtttaaaac ttccgaagaa gcgtacatgt atgaagaaga aattataact cctgaactaa 109020 taaaaagcaa aaattattat aatatgaaac ctggtggaat tggtggaatt gttatgactg 109080 cagaggttat agcaaagatg aaagaatctt ccgctaagag atttgaaaac tcaccgggca 109140 cggtattagg tacaacttgt tacactaatg gaactaaaaa tatttttatt aaacctggag 109200 aacttgttcc agaaggattt gtaaaaggga tggttcatct taatagaaag tccagaaaag 109260 gatgtaaagt caaaccgact accacaggaa ctttttgggt caataatgga gcaataaata 109320 aattaataca accagacggt attattcccg acggatttat taaaggtcgt ctcatgaaaa 109380 gagactctaa aggcaaattt agtaaggcat aattatggat attaaagtac attttcacga 109440 cttcagtcat gtacgcatcg attgtgaaga gagcacgttc cacgaattaa gagatttctt 109500 ttcgtttgag gccgatggat ataggtttaa tcctcgcttc agatatggca actgggatgg 109560 acgaatccgt cttttagatt ataatcgcct tcttccattc ggtttagtcg ggcaaattaa 109620 aaagttctgt gataactttg gctataaagc ctggattgac ccgcaaatta acgaaaaaga 109680 agaattatca agaaaagatt ttgatgaatg gctttctaaa ttagaaatct attcaggaaa 109740 taaaagaatt gaaccgcatt ggtatcaaaa agatgcagtg ttcgaaggat tagttaatcg 109800 tcgtagaatt cttaatcttc caacatccgc aggtaaatct ttaattcaag ctttgcttgc 109860 tcggtattat ttggaaaatt atgaaggtaa aattcttatc attgttccaa caactgctct 109920 gacaactcag atggctgatg actttgttga ctatcgttta ttcagtcatg caatgataaa 109980 gaaaatcggc ggtggagcat caaaagatga taaatataaa aatgatgcac cagtcgttgt 110040 tggtacatgg caaactgtag taaaacaacc gaaagaatgg ttctcacagt ttggaatgat 110100 gatgaatgat gaatgtcatc ttgctacagg aaaaagtatt tcatctatca tatcaggttt 110160 aaataactgt atgtttaaat ttggtttgtc tggttcatta cgtgatggca aagctaatat 110220 catgcagtat gttggaatgt ttggcgaaat atttaagcca gtaacgactt ctaaattaat 110280 ggaagatgga caagtaactg agttaaaaat taatagtatt tttcttcgct atcccgatga 110340 gttcactact aaattaaagg gaaaaactta ccaagaagaa ataaaaatta ttactggact 110400 cagtaaaaga aataaatgga tcgctaaatt agctattaag cttgcacaaa aagatgaaaa 110460 cgcttttgtc atgtttaaac acgtatcgca cggtaaagct attttcgatt taattaaaaa 110520 tgaatacgat aaagtttatt acgtatcagg ggaagttgat accgaaacac gcaacgtaat 110580 gaaaacctta gctgaaaacg gtaaaggaat aattatagta gctagttatg gtgtattttc 110640 tactggtatt tcagttaaaa atctgcatca cgttgtttta gcgcacggtg ttaaatcaaa 110700 aatcattgta ttacaaacaa tcggtcgtgt attacgtaag cacggttcta agacaatagc 110760 aacggtctgg gacctcatag atgacgcggg cgtagtttct aaatcaaaaa catcttctaa 110820 aaaatactcg catttaaact atcttttaaa acatggactt gatcgtattc agcgttatgc 110880 tgatgagaag tttaattatg tgatgaaaga ggttaaactt tgaattataa attaatatac 110940 gataatttaa ttaatagagc ccagaatcgg gctcgcctta atggatacac tgaaactcat 111000 catataattc ctagatgtat gggcggtaca gatgataagt gtaatttggt agaactaaca 111060 gctgaagagc attttatagc tcataaactt ttagctaaaa ttcatccaaa ccattacggt 111120 ataattaaag ccgttatatg tatggggatg aattcaaaga ctcatgaaag acacgttaat 111180 aaatcttacg cctgggaacg tcgtaaaatg gcagaacttc aatcaggtga aggtaatcca 111240 ttttacggaa aacaccatac ggaagaacat aaacaatata tgtcaaaact catgaaaaat 111300 cgtccaatta catggggaag taaaattagt aaaactaaaa gaatgaaccc aacaaaatgg 111360 actgaagaag ctaaaagatt gcattctatc aatcaatcag gtaaaaataa tggcatgtat 111420 ggaaggaaac attccgctaa atctattcag aaaattaaag ataatatgcc agataattca 111480 ggagctaata acccagctgc taaacctata gaagtaaatg gtgttaagta taaatgtatg 111540 aaagatgctt ctaaagctac tggattatca atgtacaaac taagaatact tagaaaaaca 111600 gttaatttat aagggcttcg gccctttgga gaaaaagatg ttactagaat ttaaacaatt 111660 tctttatgaa gcttctattg atgaatttat gggtaaaatt gcctcttgtc aaacattaga 111720 aggtttagaa gaacttgaag cttattataa gaaaagagtc aaagaaactg aattaaaaga 111780 tactgatgac atctccgtga gagatgcttt ggcaggaaaa agagctgaat tagaagattc 111840 agacgatgaa gtagaagaaa gcttttaaat taaaaaaggc ccaaccaaaa aggaagggcc 111900 aaaactatag actaaaggtc acactatagc aaaagttgtg tttcatttaa ttgttcttcc 111960 gaactttctg aaactggtag ttctttaatg taattatagc aaggcccagg atgtacagga 112020 cctttgtctg tttcaacaac caatgcagaa tcgattggag ttttacagac aacacaaatc 112080 ttatctgaca tgattgtctc ctctgaatta tatatctatt tatacaactc tcatatgcat 112140 atcaatgccc atatctttag aataaaaata ttcatcaaga tatccggcaa attttccttt 112200 aatataaagg acatcttcac tgcacgggtg gtcggccagg atacgaatat cctgacgctt 112260 aagattatac tttttcatta agaattgaat ttccgtttca aattcttctt cataattaaa 112320 agcatcatca atgttatatc tcattatttt ccagcctcaa atgcccgcat gtcttgaata 112380 tgcttaatag caaatccacg tgatttaata gcatcaagag ctccgctaca gaaatctaat 112440 aaaatccccc aatactgtaa cgaggtatca acctttaaaa catccttatc agctgataga 112500 actgttttca tttctgattt ctcataacga tccatactaa attcatcacc atctcctcgt 112560 cccgagtagt agtctaattt agctttaaga gcaacttttt tctgtgcttc aattctaagc 112620 atttcctttt taatacttga atgcttatta agccatttac tatataacat cacattatta 112680 gctgcttcat actgtaattt agtcgaatct ataaacacat ctttcttcaa ttcttcttga 112740 agatcttcta atctcatatt gttctctatt caattgttat tggatggact tagattcatt 112800 ataccacgtt ttaacgtgaa gcattatact ctattactgg aagccagttg cagttttatc 112860 tgctcaatat catcagggtt atcaatgacc gaaaagcgta tttctactat cagagtataa 112920 tcatcataaa ctggtattac attaactgct aatttatcaa tacgcggctc gtagtttctt 112980 actgcgcttt caatgttacg ctcaacagta tcagcagtaa gaggagtcat attctcaaaa 113040 agctgatcag ataaatcaca tccaaattcc gggtcaaatg gtctcgaccc ttttctggtt 113100 gtaataattc ccaaaaggct atttttaatt gaccttaatc caagagatct agaaacatct 113160 ttgtcccaat ccattttcat ttctgggtca atgtcagaat aaagcttatt aatatttgcc 113220 attacaatag ctcaaagaat tctttgagtc ctcttattac atgagcgtga gattttccac 113280 actctggaca cttaattgga acagccaaat acacagtagg ctttaaaagc atatctttta 113340 tagctacaat atctgactct gtgatgatag aatataaatc ttccaactct ttttcattta 113400 agtcttcaat tggaatgctt tcaccgttag catgaatcgt ttctatacat gatactatca 113460 tgtgggctat atttttatca tcaaaaattt tagggtaatg gaacttaatt ttaatgtcac 113520 ccagtgtata ccagaggtct tctggtgcat ctatttgtgt atgtaataga tttatatggg 113580 ttggtatttc agttccgcag gtgcacttcc aggagttttc gtgattaact tcgccgagag 113640 aatgtgccca taaatgaatc aacaatagtt ctgattcttg gcggtttaaa tcttttgcat 113700 ttgtgcagtc tttgattagc tttttaacaa ttacttctac ggaaccatta tttttggcag 113760 taataagttc tagatattct ttaagcgtga atgcgcgaca attgattatt ttagaaccaa 113820 ctctcacatc aaatttgtat tcatacatat tttagctcct ttatttatca tatttataaa 113880 tagaataaaa ggagcatcta tggcaaacat tattcgttgt aaattaccag atggtgttca 113940 tcgttttaaa ccatttacgg tagaagatta tcgagatttt ttgttagttc gaaacgatat 114000 agaacatcgg tcaccacaag aacaaaaaga aataattact gatttaattg atgattattt 114060 tggagactat ccgaagactt ggcaaccatt tatatttttg caggtatttg tagggtcaat 114120 aggtaaaact aaagtaccgg tcacatttgt atgtccaaaa tgtaaaaaag aaaagacagt 114180 tccatttgaa atatatcaaa aagaattaaa ggaacctatt tttgatgtag ctaatgttaa 114240 aattaaatta aagtttcctt ctgagtttta tgaaaataaa gcaaagatga ttactgaaaa 114300 tattcattct gttcaagtag atgaaatatg gtatgattgg aaggaaatta acgagtccag 114360 tcaaatagaa ctagttgacg ccatcgagat agaaacatta gaaaaaattc tcaatgcaat 114420 gaatcctatt aatttaactc tacatatgtc atgctgtaat aagtacatta aaaaatacac 114480 tgatatagta gacgtgttta agctattagt taacccagat gagatattta ctttttatca 114540 aattaatcac acactcgtaa aaagtaatta tagcttaaat tcaataatga aaatgattcc 114600 tgctgagcgc ggattcgtat taaaactgat tgagaaggat aaacaataat gagtatgctg 114660 caacgcccag gatatccaaa tctcagcgtt aaattatttg atagctacga cgcttggagt 114720 aataatagat ttgttgaatt agctgctact attaccacat taactatgcg ggattctctt 114780 tatggccgaa atgaaggaat gctgcagttt tatgattcta aaaatatcca tacaaaaatg 114840 gatggaaatg aaataattca gatttctgta gctaatgcaa acgatattaa taatgttaaa 114900 acacgaattt atggatgtaa gcatttttct gtatctgtag attcaaaggg tgataacatc 114960 attgctattg aattgggaac tattcattcc atagaaaatc ttaaatttgg cagaccgttt 115020 ttctctgatg caggtgaatc tataaaggaa atgcttggcg tcatttatca ggatcgcacg 115080 ttattaactc cagcaataaa tgctataaat gcttatgttc ctgatattcc atggactagc 115140 acatttgaaa actatttgtc gtatgtcaga gaagttgctc tagctgtagg aagtgacaaa 115200 tttgtatttg tgtggcaaga catcatggga gttaacatga tggactatga tatgatgata 115260 aatcaagaac cgtatccaat gattgtcggt gagccatctt taataggtca attcatccaa 115320 gaattaaaat atccattagc atatgatttc gtttggttga ctaaatcgaa tcctcacaaa 115380 cgcgacccaa tgaaaaatgc tactatttat gctcattcat ttttagattc ttcattgcca 115440 atgattacta caggaaaggg cgaaaactct attgtagtgt caaggtcagg tgcttattct 115500 gaaatgactt ataggaatgg ctatgaagaa gctattcgtc ttcaaactat ggcgcaatat 115560 gacggctatg ctaaatgttc tactgtcggt aattttaact tgactcctgg cgttaaaatt 115620 atttttaatg atagtaaaaa ccaatttaaa acagaatttt acgttgatga agttatccat 115680 gaattatcca ataataattc agtaactcat ctatatatgt tcactaatgc aacgaaactg 115740 gaaacaatag acccagttaa ggttaaaaat gaatttaaat ctgatactac cactgaagaa 115800 agtagttctt ccaataagca ataaagaagt ttctattcct aaaatgggtc ttaaacatta 115860 taacattttg aaagatgtta aaggtcctga tgaaaattta aaacttctta ttgattctat 115920 ttgtccgaat ttatcaccag cagaagttga tttcgtttcc attcatttat tggaatttaa 115980 tggaaagatt aaatctcgta aagaaataga tggttatact tatgacatta atgatgttta 116040 tgtatgccaa agattagaat ttcaatacca aggaaataca ttttatttta gacctcctgg 116100 aaaatttgaa caatttttaa cggtgagcga tatgttatcc aaatgcttgc ttaaggtcaa 116160 tgatgaagtt aaagaaatta attttcttga gatgccagca ttcgttttaa aatgggcaaa 116220 tgatattttt acaactttag caattcctgg ccctaatggt ccaataaccg gaattggcaa 116280 tattattgga ttatttgaat gaaaaagcca caagaaatgc aaacgatgcg tagaaaagtt 116340 atttcagata ataaaccaac acaggaagcg gctaaatccg cttctaacac tttatctgga 116400 cttaacgata tatctacgaa attggatgat gctcaagctg cttctgaatt aattgctcaa 116460 actgttgaag aaaaatcgaa tgaaataatt ggagcaattg acaatgtaga aagcgcagtg 116520 agtgatacta ctgctggttc tgagttaatt gctgaaactg tagaaattgg caacaatatt 116580 aataaagaaa tcggtgaatc actcggaagt aaattagata aattaacaag tttactagag 116640 caaaaaatcc agacagctgg aattcaacag actggaacta gtttagctac ggttgaaagc 116700 gctattcctg ttaaagttgt tgaggacgat acagctgaat ctgtgggtcc tttattaccg 116760 gctcctgaag cagttaataa tgatcctgat gctgattttt tccctacccc tcagccagtt 116820 gaacctaaac aagaatcgcc agaagaaaaa cagaaaaaag acgcatttaa cttaaaatta 116880 tctcaagctt tagataaatt aacaaagact gttgatttcg gatttaagaa atctatttca 116940 attactgata aaatatcaag catgctattt aagtataccg tcagtgctgc tattgaagct 117000 gctaaaatga cagcaatgat attggctgtt gttgtcggaa tagacctgtt gatggttcat 117060 ttcaaatatt ggtcagataa attttcacag gcttgggatt tgtttagttc aaactttact 117120 aaattctcta gtgaaacagg aacatggggt cctttattac agagcatctt tagttctatt 117180 gatgaaatta aaaaattctg ggaagaggga gattggggcg gtttgacggt agctattgta 117240 gaagggcttg gaaaggttct ttataattta ggagaactta ttcagcttgg aatggctaaa 117300 ttatctgctg caattcttcg agtcattcct ggcatgaagg ataccgctga tgaagtagaa 117360 ggaagagcac tagaaaattt ccaaaattct actggagcat ctctcaataa agaagaccag 117420 gaaaaagttg caaattatca agataaacga atgaacggag accttggtcc gatagcaaaa 117480 ggattagata aaattgctaa ttggaaaact cgtgcatcta actggattcg tggcgttgat 117540 aataaagaag cattgacaac cgatgaagaa cgcgcagcag aagaagaaaa attaaagcag 117600 ctttcaccag aagaaagaaa aaatgcttta atgaaggcta atgaagctcg ggccgcgatg 117660 attcgttttg aaaaatatgc tgattcagct gatatgagta aagactcaac ggttaaatca 117720 gttgaagctg cctatgaaga ccttaaaaaa cggatggatg acccggattt aaataattca 117780 ccggcagtta aaaaagaact tgctgctaga ttttctaaaa ttgatgctac ttatcaagag 117840 ctcaagaaaa atcagcctaa tgccaaacct gaaacttctg ctaaatcgcc agaagcaaaa 117900 caagtccagg taatagaaaa gaacaaagca cagcaagctc ctgttcaaca agcatctcct 117960 tcgatcaata atactaataa tgttgttaag aaaaatactg tcgttcataa tatgacaccc 118020 gtaacgagca cgactgctcc tggtgtattt gatgcgaccg gagttaatta aggaataata 118080 tggcaattgt taaagaaata actgctgatt taattaaaaa gtccggtgag aaaatttcag 118140 ccggacagag tactaaatca gaagtagcaa ctaaaacata cactgcccag tttccaactg 118200 ggcgtgctag tggtaatgac actacagggg acttccaggt aacagatcta tataagaatg 118260 gattattatt tactgcatac aatatgtcat ctagggattc tggaagtctt agatcgatga 118320 gatctaacta ctcttcttca tcttcgagta ttttaagtac agctagaaac actattagta 118380 gtacagtatc aaaactatca aatggattaa tatcaaataa taattcagga acaataagta 118440 aagctcctgt cgcaaacatt cttttaccga gatctaaatc tgacgttgat acatcatcac 118500 atagatttaa tgatgttcaa gaaagtctta ttagcagagg cggaggtact gctactggtg 118560 tgttaagtaa tattgcttca actgcagtat ttggggcact ggaaagtata acacaaggta 118620 taatggctga taataatgaa cagatttata cgacagctag aagtatgtat ggcggtgctg 118680 agaatagaac taaagtgttt acatgggatt tgacgccacg ttcaacagaa gatttaatgg 118740 ctattattaa tatctatcaa tattttaact atttttctta tggtgaaacg ggtaaatctc 118800 aatatgctgc tgaaataaag gggtatttag atgattggta tcgttctacg ttaattgaac 118860 ctttatctcc ggaagacgca gctaaaaata aaacactatt tgagaaaatg acatcgagtt 118920 taactaacgt tctagtagtt tcaaacccga caatttggat ggtgaaaaac tttggtgcaa 118980 catctaagtt tgatggaaaa acggaaatat ttggcccatg ccaaatacag agcatcagat 119040 ttgataaaac gcctaatggt aactttaacg gattagctat tgctccaaac ctccctagta 119100 catttactct tgagattact atgagagaaa ttatcacgtt aaaccgtgct tctttatatg 119160 cggggacttt ttaatgtatt ctttagagga atttaataat caagcaataa acgcagattt 119220 ccaacgtaat aatatgttta gctgcgtttt tgcgacaact ccatcaacta aaagctcttc 119280 gttgataagt tcaattagca acttttctta taataacttg ggtctaaatt cagattggtt 119340 aggattgact caaggcgata ttaatcaggg aattaccacg ctaattaccg ctggcacaca 119400 aaaactgata agaaaatcag gggttagtaa atatcttatt ggtgccatga gtcaacgtac 119460 agttcaaagt ttattgggct catttacagt tggtacatat ttaattgact tctttaacat 119520 ggcatataac tcatctggat tgatgatata ttctgtaaaa atgccagaga atagattatc 119580 ctatgaaact gactggaact ataattctcc taatattcgt ataactggga gagaattaga 119640 ccctttggtt atttcattta ggatggattc agaagcttgt aactatcgtg cgatgcaaga 119700 ctgggttaac gctgttcaag acccagtaac tggattgcgt gctttgccac aagatgtcga 119760 ggcagatatt caggttaatc ttcatgctcg taatggatta cctcatactg cggtgatgtt 119820 cactggatgc attccaatgt cagtgagcgc tcctgagcta tcatatgatg gagataacca 119880 aataactaca tttgatgtta cttttgcgta tagagtcatg caggctgggt cggttgatag 119940 acaagctgcg cttgagtggc ttgaatctgc tgctataaac ggtattcaaa gcgttctcgg 120000 aaatagtgga ggtgttactg gattatctaa ttcgctttca cgacttagta gattaggagg 120060 aactgctgga agcatttcaa acattaatac tatgacggga attgtcaact cgcaaagtaa 120120 aatattagga gcaatataac aatggggacc gaaaggtccc catattttta tttacggaat 120180 gaaatgaaag cagcaactga agcaactaaa ctgtcttcaa tataaacttc aatttttacc 120240 ggagcttctg actcaaattt acctgttact acaccttgga aaatgctttc agtctgttct 120300 ggctttgaaa aattttcaga aggaaaaatt ccgaactttt tatctgttcc aaaaattttg 120360 ataaattcat cataaactgc ttcattaaaa gcgttatcag caggaataac gccttcaact 120420 acaagttctt gacctaaaaa gcgtaaagaa gatttcattt tgtgttcctc atgttatgtc 120480 agtaagacta ctataacaca acacgaggga cttgtaaact acattttgaa ctttttagac 120540 attccgttga tgttaaccaa agaagctaag atttgagaaa cttcgttttc ctcttctttt 120600 gattcttcta caaggaattg attaaatcca gccattggac gaacttcacc agtttccatt 120660 agatggtcgc catcatatac tgattcttct aattgttcag aaggaggaac gattgtgcct 120720 tcaattagat acttgttata agcagtttct ttcatcatgt acgtgcttac tttattaatc 120780 ttcaacaaaa ttccacgcgg tagaataact tcagcttctg atggaaatcc tgataaatga 120840 cctggaacga taactttaat tcgctcagct ccttttatta ccatacccac gctagtttca 120900 gcatcttcat tagcatatgc ggaatgacta cccatatgca ttaaatcttc ggcatcaaca 120960 gaaccttctc cttcaccaga aaatactgcg ccggaatcat ctagagccat atagttttta 121020 ccatgctcac cgaagatatt tggtttaagc gatgttgata cgaagttctt gaaatagaac 121080 attttatttt caatattatg gcgtaaagtt ttaaaagtaa cttcttgtcc acgataaagc 121140 gtagttcccg gaggaagaac tgatcctttg gcgaatgcag aatccaacgt ctcgatgtgt 121200 ttaatagctc gttccatgta ttcttcacgg gtagaatctg gtttacccaa gaggaacgag 121260 ttcatttcaa catatgaatc tgcacaataa tcttcaatta catcagactc agcctgagtc 121320 agtccttttg gagttacttc ggtgcttgcg tattcatatg cctgagcagc agattcatta 121380 atcaatttat aaatgccatt catgacaaat tgaataatag ctaccttttc gtctggtgtg 121440 gctttagaac ctttaactaa atcattgata attttcttaa taacatcaaa gctattagaa 121500 atattaatgt cagcgagatc gctcaaaatt ttatcggttt tataatcaaa aaattcttta 121560 ttctttaaat attcttgaga accttgatgt gttatatcgc tctgcagtct gatagacgga 121620 tcacgtaaac gtgcatgggc caatgcaata tgatttcgga agctttctag ttcataatcg 121680 ttagatttaa aacgagaagc acttctcata ccaccgatag ctcctttgcc gaagtttgaa 121740 ccaatctgaa taacgccaga gttcattggt ccttctgctt tatatacagg aactttagat 121800 tcaaactctt gatatttctt ggcagcgaag ctatcaccct gaagtgaagc atcgacagta 121860 gaatattgag cttgcgctgc taatcgacga ctaattttag ttttctgaat aacagcttga 121920 tccgtgcgct tatcattttc taaagcaata gaagcagcaa cagcaacagc tttaggaaca 121980 gcattacctg ttttaacatc tacataaaca tcaccaacct ttgattcaac ttttgtgaat 122040 aactcagttg aaataggagg tacgcctgga atgtcttcta aattggcatt tttacggtaa 122100 accataatat atgcatactt tttatcataa tcccagattt cctttaaaag aacatatcga 122160 cctgctcctt tagtacgtac taaacgatca gcaataactt gcatttgacg agctgcgcca 122220 tttgttttac tttttagtac gcggaatagg catgcgtcaa ttttatactg tttcattgtt 122280 tgaagagcag tatcaaaaac cgcattaatg acaccaattg gatttccacc caagttttta 122340 agtttaacta atgatagttt ctcattaaca cctatcatta cgatatgcat cattttatcg 122400 cctggcttaa cgtttttatt tgtatcacca ccagaggtgt atgtacaaaa tctaaatcca 122460 ggaagcacac tttcttcgcc ggcttgaata gcaaaaattt gaggtatttt atgcttagga 122520 tttaagttaa caaccggcgc cgaagcgccg tcaaataatt ctgtaataag ttccatgatt 122580 tatccttgaa cgaacttgta aggcatgttt gtaatatcta tgcaagacgc aataattcca 122640 agagatgatt ctactttttg tttaacattt gatgaaacaa atgatgcaaa gtcaactctg 122700 tcttctattt caatatcacc tgtcattgca actacttcac cagtttccat tagacggtca 122760 ccgtcataaa ttactgattc ggtgagttct tccgtagtca taacttcagc ttgaatgagt 122820 tttgtattat tagatgttgt tccgtcatta ttagaagcat cagttatttt attaactttg 122880 accatcaatc cgcgtggtag aataacttca gcttctgttg ctattccgag acttcctgga 122940 tatacaacat taactttatg agctccatca attgcccatc ctatttgaac tttaacgtat 123000 tcaggatttt ctttatacgc tcttatttcg tttggattaa tagttattcc ttcttcattt 123060 ttatcaactg ttaattcatt acgagcttct ggttctaaaa gaccaatacc agcatgtgta 123120 attccaaaac gtccaaaaat gataggagtt aaagaagtag atacaaaatt tctgaaatag 123180 aatactttat ttttaactag tgcttcgtat ataggagcag tcatactttg agcacgataa 123240 actgtaatgc cttctggtat acggtcacca ttttcaaaag ctgaatctaa gttatttata 123300 gcagattcaa tttctttttc actcattaca tcatatcgtt ctggattgta gcgtcctaaa 123360 agaagattat tgatgtcagt atatcctgaa ccgcaatact ctctaatgcc gcgcttttgt 123420 gatggagtat atttagaacc atcacgggca atagtaatat caatcattgg acctgcacca 123480 attccagaaa agctataaat cattcgtttg aggaatttag tttttgctgc gttccaggaa 123540 tttttagtta tttcttccca gacttcatct ggctgtcctt tacgggtttt attatgttta 123600 tcaagccaat tatctttata ttcttcaaag agttgattaa cagctgctgc gtatttctcc 123660 aaacatttta ttgaagtagt tggttcattt ttaatcgcat taagaattac atctttaatc 123720 ttttcagaaa cttcattaac ctcacttttt gaaaagaatt tatagtcata atgaagttca 123780 tctgcagttc cttcagcaat aatttttgct gccttagttt tagaagctaa tgaattaatt 123840 ccaagcttca tttcttctgc ttcgggaatt aaaggagctg tagcaggttt attgaaatta 123900 gctgcggtag attcatactt ctggaataat tcactttcaa atctagaaga ttctaatgat 123960 tgactttgtg caattgctct acgggaaatt ttaactttaa cgattacagc ttggtcagaa 124020 cgtttatcgt tttcttgcgc aatagatgct gcaattgcct catttttagt tacttgagct 124080 ccggtatctt tattgatata aacatcaccg accttcgatt caactttagt aaagagctcg 124140 gtactaattt ctggaactcc tggaatgtct tctagtgata catttttacg atgtataaga 124200 atatatgcat actttttatc gtaatcccag agttccttaa gaaggacgta tctgccacct 124260 gaacgactac ggataagtct atcagcaata acttgaattt gtcgagcttg gccagcagtt 124320 ttagacttaa gaatacgaag catacaagca tcaattttat attgacgcat tgtttgcatt 124380 gcaacagtaa aaactgaatt gatataatta attgggcttg gaccaagacc ttttaattta 124440 gcaattgaac ctttagcagt taatgtaaaa ggaacaatgt gcatcatttt gtcgcccatt 124500 tttaaatcgc gattagtatc acctccagat gtatatgtac ataaacgaaa gcctggttgt 124560 tcaattgcat catcaacatg aactgaaaaa atttgtggta ttttcttctt tggatttaag 124620 tttgtaatcg gaagagtagt atcttcgtca aataattctg taataagttc catcatagcc 124680 tctctagtgt ttattctatt tataaaatta aaggcccgaa ggcctttagt aatctagtgg 124740 taagagagta cgatatattt caaactttgg tcctttttca taggcatcaa atgtttctgt 124800 aaatttattg taagcatatg catctacaaa ttcgagaatg acttgtgata cagaagtaga 124860 aacatctcca ccttcttttt gagcaatgac aattgtttct aagtaagctt tcataaacca 124920 gttacctcat gaaaatcgcc aaatacatcc tcgaatgtat tagctttagt tttatcttca 124980 cgtaaacgaa tcgcaatcgg aagaaataat ttaacgtaat cagtgcggcc atcagatttt 125040 aaccaaccgt tgcattcgca ctctagaatt tttccaatat aataattttg gttttccata 125100 atgcgagtac ggtcaagttc atgcgatttt acaccagctt tatcttttaa gcctgaacca 125160 gcatttactt taatttttcc acactctgac tcaagaataa atccacccgc tttagtaggg 125220 tctttacggt gaggataaat tcctacaatt tttaaatcaa catcaattac ttctttaaat 125280 ttataaagat tttttgaacg agcattttcc cataatccat cgatattttt gagaataata 125340 ccttcaagac cttggtcaat atactttttg taaattacct tagcttcatc taggttattt 125400 actacctggt tttcaattaa aattacttta tcatatcccg atgtcatttg ttctagttta 125460 gaaaaacgta catcatattt caaacgaaat gctggaagac catatatttc tactaatgga 125520 acataatccc agacctgaaa cttcatgcat tgagcttctt tttctgaaat ggttcccttt 125580 aaagatttat tagcgattcc attagaagta gtacgtgatt cagctacttc ggcgaattct 125640 ttagctttac taatttcagg ataagcatca aaaagaaaat ctaggccttc tggttccttt 125700 tcaacttgct catggtatac caattcgcca tcaattaaca caccttctgg atgaatctgg 125760 cgagcttctg cagtcatttt gattaactct tccttgagaa gatctaatcc tagatattca 125820 ttaccagctc gtgataaaag acgaacatca tctaattcat cacctctgac ttcagcaaag 125880 caccgagctc catcagcttt taactgggca aaagctggaa atttgatatt cttattaatg 125940 cctttttcat cataagaact tgccagcatt tgaggttgtt caggaattaa acctggccaa 126000 actttgtttg caatagatac tgatgcacca cattcaaggt ctcgcatcat cacccgacgc 126060 aaaacttcaa catcatcttt tttaccgtca gcaatatatc cagttaattc ctcaattgcc 126120 gcatttccgg tcaatttccg agtagctaac gtgaattcaa tgaagtcaag catatcggta 126180 agagttaaca ttccaaaact ctgggtagaa atacccggtt taggccattt cttgatataa 126240 tactgcaacc cacgagaata agtcagacga tatactcgtt taagcaattc attatcttta 126300 ttcttttcaa gaattgcttg cttctgctta gttgaaccaa tagatgctat ttcgttcaga 126360 attttaagaa tcattgttca tcctttagag tttggtttac agctctatta taaatcaatt 126420 catcattaag ctcagtcaaa gacttgtggt acgtggttct aactttattt ccttgcatcc 126480 agtgcttgac gtaaatgaaa ccttgctcta cacatttttt aaaaattcgt tcgtcttttt 126540 gagctcggaa ttctggattg catctaaaaa attgatttac gtgaccgtaa tcacgtgtag 126600 tattaccttc attttcataa atagtgtgaa caacaaacat tagaatgctc cttggaaaat 126660 attatcacca ctagtaggtc tattatacaa atactctatg ccaccaggtt taatatagtt 126720 ccatgtctga aacggacgtg tctgatatgg atgatataga tgattataag gattaaatcc 126780 aggagttctc caggtagtgt tccaaggaaa agaatcgttt ttaaccatct tctcgattac 126840 atcttttata gctttttcac aatcaaaact ttctttattt tccttcggtg aaaaaagctt 126900 attctctaca tcattccatg tataaactcg ctgcgcagtt tttggaatac tgtcacgctc 126960 ccctcgagcc atccaataaa caggaacatt taatatttca ctcgcgtgat cgcagtggtg 127020 agcgagatcg tcaatataac aaattacgtt atatttctct tttgcctttt tgaacaactc 127080 ttcttttgaa gaatcatgac cacacatcaa tacttctgag aaggcaccag gaaaaagagc 127140 attcaaatta aattgacgat ttagcagagc gtcaatagaa tcacccaatg ctgtaacagc 127200 tacaaaatta taatcttctt ttaatttgtt aattacacac agggcatctt tatacggaga 127260 caagtaacga ataaaatctg aacgattata cttttcgatt aatttaacac caagttcttc 127320 atcgcaatta aagagcttac caggagaaat aaatttttcg tcctgaatca tttttaaaat 127380 atgttccaac ggaagattat atttttgggc aaaataagga aggcccgatt gccagcttaa 127440 acacaccccg tcaatatcag tcaaaatagt aggcttcata gagagtctct taataggttt 127500 aacacatcaa taaattcagc ttcggttagt attgtatcat cttttgttag accactagcc 127560 atgctatgct tcaaaacttt tcctttcgag gctagtaatg catcacgaaa gcccttgttt 127620 tgaatcgctg cttcaaaata tgcatttgtg tacaactctt tccacgctgg tgagtatctt 127680 gaaaacggaa ctccaagcca gaagagggtc ccacggtcct gagctctagc ataagacctt 127740 ccagcttgtt gggcggcaag cccggataac ccaaatacac gacgttgctg ttcaacattt 127800 ttcaccttac atccttggag gaatccttcg agacctccaa attgaatgcc atccataacg 127860 aaaggccaat aggcgaaatt acttaatgca catgatggcc acctaaaatt acttctaatc 127920 tctaactcag acattttcaa tgcttataat ttcaacatca gcccaatgac catagtttgg 127980 tagacgaaat tcaactggcc agtcactgcc tttttctaat ataatagact taacttgcgg 128040 ttcttcatgt tcatcagtat atggattttt atctgttact ttatatgtga ccttaatgta 128100 ctgaattcca aaaatcttat taattatatt catactaatt cctttaatcc gtaaatagga 128160 gataattcat cacccatacg aaggtcttca tttccatcta cccaggaaac aatataagcc 128220 tcttttattt gaacaccact ccatttaaat ggaggtagaa ccttagaaat taatccaggt 128280 ataccaactc cctttaattc aacagtttga cctaaaaaga atttcatcag aacctcatct 128340 gaaagccgtg tgatttaaca ttaccgccgc caatatcaga aatattaatt tcacgcgcaa 128400 ttgaagggtc aatgtcaatt tcacgattaa gtttagcgat agctaaagta tcacgcccat 128460 ttactgtacg gaattctaaa ggacaaacca catcaacata atttttaatc gattcactgg 128520 taggttgcaa atgagcagga aggtctttag gcgccttaga gaaaacaact tcacagaaat 128580 ttttgcgggt atcaaaataa gtagtcataa acatagtatt ttcctcagta aggggccgaa 128640 gcccctgttt tattttaaat atcaaattcg ttaagaacta catcaaagat tgcttcaaga 128700 tgctcaggtt tagctctgtt actcaaaata tgacgaatcc aagttttaac cagaagctta 128760 cgattagcgc cattccagca aggatgggtc cctaaatcgc gttgacgaaa atcatcatcc 128820 agagcgattt tgaagtttga accttccatt gtgattgaaa ccgtgatgcc attttcaaat 128880 cgcatataaa cgtagttagg agtcatatac tgttcaattt cgcatactga tccattttga 128940 tgtttccaaa ggcaaatagt atcaatagaa cctgcaatac cattagaaac atatttacgt 129000 tcaaagttga tgtagttcat ttttattctc cgagatgttt aattgcggta caggtatata 129060 atatcatatc ctgtaccaaa gtaaacaatt attttactac tttccagtgc ttcatgtcaa 129120 gtttaccaac ttttttcatc ttctcaatca aacgttcggc acgttggcga gctgtaacat 129180 aataccattc gcctaattca ttttgttcaa tttttccaac gattactgta ttcaattcat 129240 aaatccaacc agtaaagaaa ttatgaactt gaattgtaaa ggtgaaatct gttcccatac 129300 cttctgttgt ttctacttca ataatatcac cttcaattgc cattaagaac cacatagttt 129360 catcatattt accattgaag catttagtct taactgcagc gttcagatta atcgttttca 129420 ttttattctc ctttgtttgt gtaagataat actatcacaa aggaaccata ctgtaaacaa 129480 ctttatgcaa tctttggaaa ataaaaaagg actcccgaag gagtccttaa cttatgcttt 129540 ctgcttacca aaacgagaag catcatctcg aagaaccgca cgtgctcggc gcatgatctt 129600 ctcaacagtt tgattgatac gagagttcga cccacgcttg tagccagcgc gtttagaatc 129660 accaactttc ttttcaactg ctttctttgc tttagcttgt tttgccatta taaattctct 129720 tttaaatgaa aatgcaggac ttattggcat tgcctgcgca agccctcaag gggaacatag 129780 gttttggata tttaacgaca ggataaccat aaacccgtca tcattcacat tcaagaggta 129840 caccataaaa ctgccggggt cttaaaacta taatgattcg caaatcatta atcagacagt 129900 tcgatggctc ctcgatttta gctcacacta aggcagtgaa tctccaataa attacttcag 129960 tgttaccaca aagtgacgaa ctgcttttcg tgcagcagaa gccagaggct tagcatactt 130020 aagttcatct ttttcctgaa gctcagcagc taatgcagtt tgagcaggat tcagatgttt 130080 gaaataacgc aggatttcaa gagcttcggc ttcaacatca atagatgcgc catagttttc 130140 gtgaccatta ttccatgcgt ttcgttgcag ttcaagagcg tgttgtaatt gtttaatcat 130200 ttaaaaattc tcgttagaga ttaaaactcg gtagtcacgt tcttctgaat ttcatcttct 130260 ttcgacagat ctctcagttg tagactacca catagaattg ttcggttaac ttattattcc 130320 gacacccaat tcatattatt atttatatca cttataaaga cacggaatag ctttatagtg 130380 acaagtaacg aatttttgtt taatttcttt tggctgctta agacccagag ctacaaaagg 130440 atgcggaaca tttcgaattt gaccaactgg aagagaagtc aaatcaccaa cttcgcagaa 130500 accttcagga acatcaggac caacagagtg aattacacac agttcaggaa cttcaccttg 130560 aacacgttta ccgataataa gtcctgattc tgtaacttct tcatcaccgg cttgtgcagg 130620 ttcagaaact aaaataacat attcaccgac agcacgaatt ggtaactgtt gtacttcaga 130680 catcgttttt cctttttgtt aatagatgaa ttaataataa caaataattc ttaaagcatt 130740 tatttaccaa taaattggag taaatgctca actttcatac cattaacaga aatcaatttg 130800 tcaatagaaa aacctcgcca tgcaccaagt tcaacatcaa atactggaat catgtcagta 130860 gattctttcc gagtcgattc agtcaattta ccagtttgca tggttggcat aaagtctgcg 130920 tcacgagtac ctttcatagt acgaatagta ccatcagact tttcaaaaac tacgtttgaa 130980 acacccatgg acagtttagt tttcaaaatt tcacgaattg ctactttttg ttcagtcgtc 131040 agtttcattt atttacctat tacagtttta atatgagttc ttccacgttc tttaagagtg 131100 gaaagtaatt tttggcattt ttctaaatca gatttccaac tatatggtct atctatacta 131160 gtccaatcag ttttataata ctgtttccat ttagagaaaa aatatttctt atactctaca 131220 gcaaacgaga tgttctcgtt agaataagaa ctaattgctg taagctttac caaacgaaat 131280 ttcattattc accacagaat tcgttgatat tttcccagtt taacttattc aagtttttct 131340 taggaacatt aaacacttca atacctgcat ttcgcagaat atcatcccag ccaggtttat 131400 ttttatcgta tgtttcgcaa taaaccagtt ttttaatacc agattgagct atcgcttttg 131460 cacaatctgg acaaggagaa agtgttacat acatagtagc accttcaata gaagaaccat 131520 ttcgtgcagc aaacaaaatt gcatttagtt cagcatgaat ttcattttta gacgaccatt 131580 cagagtgagc gctccggtgt tcttttgcca agacaaaacg atcagttgaa ccaaatgata 131640 cacattcggg cttatgacct tggatgatag tatgtttagg cttattcagc aaccaacctt 131700 gctcagcagc ataatcacaa cagttcacac caccagcagg tgaaccatta tatccggtag 131760 aaataatacg tccattcttt tcaattactg ctcctacctt ccaggagcaa cattttgatt 131820 cctgcgatac taaatatgca atttgaagta ctgtactcgc tttcatttca taatcaccag 131880 ataagcagat ttagcagttt caacacgata aatttcgtga cgaagtttag ttatactttt 131940 aataacagaa ctaattatat tctgcccatc tttaaagcgg tttttcttat caataaaaat 132000 tgcgccaacc atctttttgt gaagctcaac tggatacttc gtcacaataa tagcatcata 132060 tacggaagga tgaatactat ttactagagt gtcattcatt aaagttattc taatgaactg 132120 tgctgtttca gagtcaagcg ctctatgatc gccagtatca ttttcaagac aattatcaat 132180 tatatcagtt aaattcatca tagtacgcca tacacccttt gtgcttcaac taatccatca 132240 aaatctaatt taagatgcga tatttgatcg ccatcacctg gattcacaat tactaatact 132300 gaacgaggag tttcagtaat aacacgaacc gatgtttcag gaaatcgttc agaaacctta 132360 tttaccaatt cctgtgcaaa tagcttaact ttttcttgga attctttaac agtaatcggt 132420 ttttcactta gcagcatttt gttttcctca tttgtttggt agagccataa tatcacaact 132480 ctaccataaa gtaaactatt aaatcgcttt gaattccgca gtttgagatt caaagcgaat 132540 gtcgcctttg ataactaact cagcatcaag accgaatacg acaatgatat gcgcggaacc 132600 tggatacagc gtaatggcaa cagaatccac ctggtctgga agcaaagtgt tcaatacatg 132660 agtcacttga gcatgaattc gaagctcggc tgcgttatca agcttttcaa acatattatt 132720 agcgataatt tgactaaaca ctacttctac aattttagaa taagtcggaa acatatttac 132780 ctcacataat tttcttcaag ccaatcaata acatccaacg cattatcaaa agttgaacca 132840 tctactttgt cttctgtttc ataatcaaga acatctaaac ctactcttcc atcaacaata 132900 ggccataaac aaaatagata tttcttttct ttttcaattt tatcacaaag acgataaatc 132960 ttttctaggt tattcataag ttttccatgg taaaggcagt ttagttttct ttactgttag 133020 ttcaacatca ggattctttt ctcttaattt aaggcattcc tcccaagctc tgatttcact 133080 agtgaataca caaaattgcc cattactagt accgactaaa ccactattta caataatagc 133140 ccaagtttca tgatgccacg ccattaaaaa tctcccgagt caacttgcca gcattcaaca 133200 ccgatgcggc gccacatttc aactacttga gttcggtcat caatagctaa tttcacatca 133260 aaatgtggtg cgatgtgttt ccagaaaatt tcttctttga ctacatcatc tttacgggta 133320 tcaccttgtt cgcgttgaca ttgcataact aatggaacgc cagcaatatc ctcaacccat 133380 ttacgggtca tacgataata tttcgttggg tcttcttcgg ttccactttc acggcctgaa 133440 acgactacga tgtaatatcc ttgcttatcg tacatcttag ctagttcaac aatcatagga 133500 ttgataacat cggtatcaca tttttcaagg tcataaggac cgcgaccatt catttttgct 133560 aatgtgccat caacatcaaa aataactgct tttggtttac caggagtccc tttatatacc 133620 ggaagaccga gatactctcg catgctttta tacattgagc gtaaaatatc aattggtact 133680 gctttagttc cgcgttttga gttgcgttta accaattcag tccaaggaac atcaaacact 133740 ttatattcaa tttgatgccc aagctctttg gcaaactctt cccagacctt acgtcgttca 133800 ggatttagat tagtatctga aacaattaca cccttcgtta tgtcttggca tagaatcatg 133860 ttagcaacat catgctgcat gtaagttacg atgccttctt tctttttggt atacttgtac 133920 tcgtcacgtt cttcatgacc catgatggat tgacgataat catcacgatt aatattataa 133980 aatccaggat ttttagcaat aaattcacga gcccaagtac tcttaccaga accaggacag 134040 ccaatagtca aaataatctt tttcatcatt taattcctaa gaaaacttca agaatacgaa 134100 tattatgctc acgccgtcct ttgtacaatt cagctgttga ttgattcgct gatttactct 134160 gaacattgga tgaaataaat tttatcatgt gatttttaag ctgatacata tcaagcccac 134220 gagctttcgc ttcttttcgc agggctttac cagcatcatc taaagcttta gcatgttcaa 134280 tatcttggct aatgcttgat acattttcac ggcatgcatc aatgtaacgg tctgaacatt 134340 caatataacg ttctaacaga gttttcattt atttttctca accaatgatt gaatataatc 134400 atgcaggtct ttagatgctt taccccactt attttgatat tcatttttga gattagcgcg 134460 tgattgagct aataaaacat cattagttgg aggtaaagat tctaatcgtt gaatctgtcg 134520 tccataaatc attgcagcca tctcggattc ataaattaat ccttttagat gttcaaattg 134580 ataccatgaa atcatttaca tttatcctct tttagctctt gacgataata acatatcata 134640 gttttctggt catgtacata tcgttttaca tcattaagcc aaatacgaaa ttcctgagaa 134700 tcttcaaatg gcatacctac ccaagcttta ccatcaataa ctttaacttg ccaagatagt 134760 ttagcttcgt catatgactt tatttgcaca ggccaattag gatgaactgt ttctttcttt 134820 acttctagag gctttgtcga acaaccaact agaagaccaa tagataatat tactgcagat 134880 aatttaatca tttagaaagg tcctggatgt cttctgcgaa cttgttgaag gagttgttga 134940 tttgtttttc aaccaatcct ggcttacgag ccaccacatc cgccttcttt gcatctttgc 135000 gcagtttttc attttcacgc tcaatagcag caatcgcctc acgattttta ttattcatcg 135060 catcaatata attatactga attcgcaaat tatttaatgc taaggcgttt tcattggccg 135120 tttttgtaat ttctacaaca gacgtttcta atctttctac cttatttttt aaaataatag 135180 atgttccgcc aaatgctatt acaagtaata gcaatccagc tgtaaaatta cttacatgca 135240 taaagtttta ataacctcta taatatcgtc ttgagaaaga ccgttaatta aaatatgatg 135300 ttcagccgga gatttagaaa ttttaaagca cgccgcaaca tcttctgcca tatccgatgc 135360 gctacgattt ggattactaa ttccaagacg atgctttcct gtcaaaggat taacgatgat 135420 atagcatttg cagctattga tatgaacatt aggttgagtc tgattaataa acacttcaca 135480 atcatactta gcgagttgat tttctaaaaa gactttcatc tcctcaaccg catcaggaag 135540 catatcacgg gcttgctcaa gacgacgatt tcgatattct ttaatggtcg ttttccgctt 135600 gacttgctta gctaaatctt tcttaagatc ggtgatatat ccaactcgac gatttccttt 135660 gaatacagaa atcccatctg tagtatcacc gtatgcttca acgaccattt cagtagtaat 135720 aatctgcaaa tccatcataa agtcctcatg ttatgtcagt aagattacta taacacaaca 135780 cgagggactt gtaaacagct tagtatcctt ctgggataaa ttttttataa tttttcaaaa 135840 aattctgttc gatttcgcac atgacctttt cttgactatc gtacccctga tataggctca 135900 taatgatacc gaacaggtga tccattccag cacctttagc aacaccttgc gcttccatcg 135960 cataagtctt tctatcctta ccacaatgct tattatgaca gtcaagaact aaaaacagag 136020 ctcggtctaa gtacttcaga taagtcgttt caaatgcttc aatttttctg tatgaatatt 136080 catcgtcagc atacattgct ttaagatcat ctgatgcacc atcaataata gtcttaaaca 136140 atttttctgg attatctaat gaactttttg tgctatgaag agacacgtac cagtcagact 136200 taattttaaa atgagaacca tctttcatca cagcaacata gccttcgatg ttttccgcat 136260 ttttagcttc ttctacccat ttagggctat cgatttcgta tcgttcaact agatatggac 136320 gaagagcagc atctttataa atatcatcat atgaaatgta ttcgcctgtt tcattttcac 136380 gaatattcaa taaaatgatt ttcatctctt gataagcaag aacgattcta ttagttggag 136440 cgacgaattc gaagttagca gtaaatccat cttcagctaa ttctttaagt ctatcacgca 136500 accgatggtg attaatattc atcaaaatac cattagccat taaagcctgt tcggatttga 136560 ttgaaccctt tgatttgaac agaatttcat caccatctaa ataagttgat accaaagacc 136620 catcttcctt tgtcagaatg taatcaacat catttaaatc gatattcatc gtgaatggat 136680 tttcgttcaa gttaaaaaac ttttccatgg gacgagaggc aattcttact ggtttttctc 136740 catccatttc aaacatgatt ccacgacatt ctagtgcgtc tggaagtaac caatcagaat 136800 aagatgcata attatatgag aaaattctgt aagttcttcc agatgcactt acatcatccg 136860 agtaaaaaaa cttacgctgt gaatccttac atagttccat taaattgtta aaaagttctt 136920 gcattgtgta tcctcttttg tgttttgaat atagtaccac actccatgtg gaagcatcat 136980 tttttcttgt gttgaatatt ccaaggcggg ttaaacagtt taatgaatag cggctcctct 137040 aggtcaatcg ttgcgattgt cattgtacct aactcatttg tcatagaaag attaaaacat 137100 tggcgggcgt aaaattcaac tttgcttcct tcctttagcg cagcatgaat taatgcagat 137160 ttagtagaat cagacgtttt gtctttacga ttaatagcag ttctataata atttattctt 137220 ttacgtaaat ttttagtttt tccaatataa acaagctcat catttatagc aatagcataa 137280 attacgttat acttatttgg aatagatagt tgttttatac ttccgttgtc gtctaattct 137340 aactcagtat atttaataaa tgaatattct gttgcaattt ctttcataat aaaatgggcc 137400 ttgcggccca ctccttaaaa gtatttttta aaactcatca taactttatc atcaacatca 137460 ttatcaatct gtgcaacaag ataagatgac agttctactt cttgcggcgc ggattgaaca 137520 ttatcagaat taaggtattc acgaatccaa ggatatggat gtttaaccgg agcatcggta 137580 atcgggcatg gaagaccaca ctgtttcata cgagatacag ttaagtaatc aataaagctc 137640 cacatgctat ttgtatttaa tccaggaaca tcgccatctt taaataaatg aactgcccaa 137700 tctttttctt gacggttaac ttccatgaaa atatcaactg cttcttgttc acactctttg 137760 gcaattttaa cccattcatc gccatcagta ccagattgaa gttgacgaat aatatattgt 137820 gtacctttaa gatgaagctg ctcatcacgt gcaataaatt tcataatctt cgcattacct 137880 tccatgattt ccatgttctt atggaagttg aaagtacatg caaaggatac ataaaaacga 137940 atagcttcca gagcattgat aacgtgcaga cagagataaa gcgacttcat caggtctcgt 138000 ttacattctt ccaaatgagt gagactgttt gaatatgctt ctaaatcata ttcattttca 138060 gcaaaataac taaagttttc tttggcgttt tcccaaatac gtgtcttgtc cagaacatca 138120 tcataataac gacccataga ttcagcacgt ttcatgatag ctttatctaa tacaatctca 138180 tcaaataccc ttgacggatc agtataaaga tttcgcataa tatgagtgta tgaacgactg 138240 tgaatagttt cactaaaagt ccatgtagca acccatgtat caaggcttgg gtctgaaatc 138300 aatgacataa gtacagcaga cggtgcacga ccctgaatgc tatccagaag tgattgatac 138360 ttcagattat tagtaaaaat attctgctga tattgaggaa gcttattaaa ctgtgcagca 138420 tccatcatta agtttacttc ttcaggacgc cagaaaaatg ataattgctt ttcggtcaaa 138480 tcttcaaaaa ctttatggcg ttgaatatca taacgcgcaa taccaagacc tgaaccaaaa 138540 aacataggtt cttttaaaac atcaactgga tttgtattaa aaactgtaga cattaatttt 138600 tcctctttaa aattctgccg cgtttccaac ctggcggtat aatatcatct ttacctataa 138660 gcgtgcattc acttccatta ttaatccatt tcttaccgcg gattccttta taatctcttg 138720 gttgtatttt gtcaaacttt gcatcaggtt gatatgccca tctaaatcca taggcatatt 138780 gaaatttacc ctcagcacaa tatttgatat ttgacccgtt tccattaact gacctggacg 138840 ctgccgcaat agagtgaaag gtttctatga aatccccatc taatgagaat ttatgtattt 138900 cgatagatgg gcatgcatac ctattcacgt ttgatacatg tcgtttagtt tcgtttttat 138960 gatgcttgcc taacattcct ctaggatgag gattattttt ccagtatttc ttaaagaaat 139020 cagaattagc tttagcaaat aattttctgt gcaagctata caatctgtta ttaattctat 139080 taccagcttt atctgttgcc attaacgtta acgcagaggc aagcccaaaa tggccttcat 139140 ttatcttaca tagtaataga tgcgctataa aatgttctct agctgttaat tcaactaaat 139200 tttctttatc atcagaacct cccatgcatt tagggactat atgatgtgtc tctttatatt 139260 cggataaagg ttcccgagcc tgagctcggg aaattaggtc gttatagatt ttttgataat 139320 tcattacaat ttacacgctg cacaatcgtc ggcttttgga gtttctattt cataatcatc 139380 agtaccggaa ccatcacggg tattatgata atagaaattt ttaatgccat aataccatcc 139440 gtatagcata tcatcaatca ttattgacat tggaaccttt ccttttggaa aaatctgcgg 139500 gtcataatat gtattcgctg aagctgattg acatacccat ttaagcataa tagctacctg 139560 cgtaagataa ggtttattac ctttcttagc taatttccat gtataatcat agaggtctat 139620 gttatgttca atattgggca cgacttgatt aaaggaaccc tcttttgatt ctttaacaga 139680 gactggtcca cgtggaggct cgataccgtt tgtactgtta gaaacttggg aagatgactc 139740 acatggcata agtgctgata atgtgctatt acggatgcca aagagcttaa ggtcttcccg 139800 cagctccgac cagtcacaaa cgtattttgg agctgcgatt tggtcaatct ttttattgta 139860 ccagtcgata ggtaattcgc ctcgagacca acgagtgtct gaataatatt cgcaaggtcc 139920 tttttctttg gcgagcttaa tggatgcttt aatgagccca tactgtaatc tctcaaatag 139980 ttcatgtgtt aaatcgttag catcttcata agaagcaaag ttacttgcca gccaagctgc 140040 atagttagta acacctacgc caaggtttcg acgcttttta gctttttctg cttcaggaac 140100 tggatatcct tggtaatcca aaagattatc aagagcgcga acttgaactt ctgctaattc 140160 attaatttta tcttggtctt gccaatcaaa gttatccaac acaaatgcag ataacgtgca 140220 caatccaatt tcagcatcag gactattcac atcatttgtt ggaatagcaa tttcacaaca 140280 caggttactc tgacgaatcg gtgccttttc acgaataaat ggagtatagt tattcgtatt 140340 atcaatgaac tgtacataaa tccttgctgt tcctgagcgt tcagtcatga gcaattcaaa 140400 cagttcacgg gctttaatac gctttttacg aatattaggg tctttttctg cagcttcgta 140460 taattcacgg aaacggtctt ggtctttaaa ataagaataa taaagctcgc cacccatttc 140520 atgcggactg aacaaagtaa tgtagtcgtt ctttccgaat cgttccatca tcaaatcatt 140580 cagctggaca ccataatcca tatggcggat acggttttct tctacgcctt tgttattttt 140640 caaaacgaga agattttcaa cttccaaatg ccaaatagga taataagcag tagcagcgcc 140700 gccacgaatt ccaccctgtg agcatgattt aacagcagtc tgaaaatgtt tccaaaaagg 140760 aataacacca gtatggcgta cttcacctgt gccaatctta gaaccttcgg cacgaatcat 140820 accaacgtta ataccaattc cagcgcgttt ggagatatat tcaacaattg aagcggaagc 140880 cttattgata gacttcagcg aatcacctgc ttcaataaca acgcatgaac taaactgccg 140940 ggttggagta cgacatccag ccataatagg agttggcaat gaaatctgtc gagtagatac 141000 cgcttcataa aaacggataa cgtgttttaa tctatcaaca ggttcatctt gatgcaatgc 141060 cattccaata gtcataaatg caaactgtgg agtttcataa atttgaccag tggttttatc 141120 tttaactaga tatttttctt ttaattgcat cgccccggaa taagtaaatt ccatatcccg 141180 ttcatgctta atttttgatt ctaaaaatgt aatttcttct gctgaatatt ttgacaacaa 141240 ttcagggtca tatttacctt catttacgca gtaagaaata tggtcaataa atgaacgtgg 141300 ttcatactgt ccataaacat gcttacgaag agcgaacatt aaacagcgtg cagctacgta 141360 ttgataatca ggctcttcaa ctgaaataga attcgcagca gccttaatta caatggtttg 141420 aatgtcatca gttgtcattc catcacggag atatgattta atattttcat ataattcata 141480 aggatctact gatgttcctt cagctgccca agataaaact ttaataattt tttgtgggtc 141540 aaagctctga gaaacaccac tacttttgat aacattaatt aattgcataa gtcctcaact 141600 tgaaaatcgt ctttaaacaa tcggttaact atatgagcta ttatatcacc atgacacggc 141660 ttcagtttac atgtgcatcc tagcctcatt ccacgtaaag gctctaaatg tgctttagtt 141720 atttctccgg atttaattcg acgtataaaa tcttttttga ataattcaat ggcagcctcc 141780 cggctgccag catctttacc gacgtaattt ccccaaaatg taccacggtg aatattaaca 141840 tcaaagtcgg atttatattt attcactacc tgacatagac ggcccgcgcg gtgataattc 141900 gtcatattgt ttttccgtta aaacagtaat atcataataa caatcagaag aagttttaac 141960 tgtagaaatt ttattatcaa aatactcacg agtcatttta tgagtataat attttttgcc 142020 ataaatgata ataggctgat ttggtcctgg aacttctaac tcgcttggat taggaagtgt 142080 aaaaagaacg acaccagaag tatctttaaa tcgtaaaatc atatatcctc gcaataataa 142140 aattacaccg ccatctttcc tttaatagga ggatgtgatt catagttgtt aagaacaaaa 142200 ttatgaggct ttgcaaattg actcaaccaa aatacctgcg attctgtgtc ccattcatca 142260 aattcatctg gaaattttaa ttgtaattcg cataaatcca taggttcacg acataaaatt 142320 tctttacatt gttctacgtg attcatatag atatgagtat taccaccaga aaatatcaaa 142380 tctccaggaa taagattaca catcttagct acaatatgaa ctaacgtagc atatgatgca 142440 atattaaatg gtagcattat gttcagataa ggtcgttaat cttaccccgg aattatatcc 142500 agctgcatgt caccatgcag atcagactat atctccaact tgttaaagca agttgtctat 142560 cgtttcgagt cacttgaccc tactccccaa agggatagtc gttaggcatt tatgtagaac 142620 caattccatt tatcagattt tacacgataa gtaactaatc cagacgaaat tttaaaatgt 142680 ctagctgcat ctgctgcaca atcaaaaata accccatcac atgaaatctt tttaatatta 142740 ctaggctttt tacctttcat cttttctgat attttagatt tagttatgtc tgaatgctta 142800 tgattaaaga atgaattatt ttcacctgaa cgatttctgc atttactaca agtataagca 142860 gaagtttgta tgcgaacacc gcacttacaa aacttatggg tttctggatt ccaacgcccg 142920 tttttacttc cgggtttact gtaaagagct ttccgaccat caggtccaag tttaagcatc 142980 ttagctttaa cagtttcaga acgtttctta ataatttctt cttttaatgg atgcgtagaa 143040 catgtatcac caaacgttgc atcagcaata ttgtatccat taattttaga attaagctct 143100 ttaatccaaa aattttctcg ttcaataatc aaatctttct catatggaat ttcttccaaa 143160 atagaacatt caaacacatt accatgtttg ttaaaagacc tctgaagttt tatagaagaa 143220 tggcatcctt tttctaaatc tttaaaatgc ctcttccatc tcttttcaaa atctttagca 143280 cttcctacat atactttatt gtttaaagta tttttaatct gataaattcc gcttttcata 143340 aatacctctt taaatataga agtatttatt aaagggcagt cctacaattt agcacgggat 143400 tgtctactag agaggttccc cgtttagata gattacaagt ataagtcacc ttatactcag 143460 gcctcaatta acccaagaaa acatctactg atcgctgata ccactgcaga tccaaatagc 143520 cattacgcac attaaattga tagaacatat gacaaggtgg taatgccatt tgcttgagtt 143580 ctgccggatt ccatgctgaa acaatttgac gtctatcatt tggcagtttt ttaatacgtt 143640 caacaacttc tataatttga tctacgccac caaaatcgcg ccactgtttt ccataaattg 143700 gaccaagttc accgctatgg tatcctaaat cttttgcttg attttcgtaa ttttcatccc 143760 aaactgtttt gccttggatt aacgaatcat gttgaattaa tcgcaaatca ttgacatttg 143820 tgcttcccga taaaaaccat attagctcag caatacaggc tttccatgct aattttttag 143880 ttgttaccac aggaaaacct ttagttaaat cccagcgtaa tttagtaccg aacaaagcaa 143940 ttgttcctgt gcctgttcgg tcatcggttt catagccatt ttccagaata tctttaatta 144000 aaaattggta ttgtttcatt agttcatcca agaatatgta gaaggatatt tggcaaagtt 144060 aggtttatat cctaatttaa ccatttgttt tgctttgcga gtaaatccta aagaacgctc 144120 acctttaaga tactgttttg gtgtcatagg cccttgatgc atctgccgac aaataaaaag 144180 ggccatagca ttaggaacat ccttaacttt taatttattg ctcatttata tactgattcc 144240 gtaagggttg ttacttcatc tattttatac caatgacttt caaccatttc acgtttgctt 144300 atatcatcaa gaaaacttgc atctaattga accgttgaat taacacgatg ccttttaacg 144360 atgcgagaaa caactacttc atctgcataa ggtaatgcag catataacag agcaggacca 144420 ccaattacac ttacattaga attttgatca agaatagtct cgaatggcgc gccagaaatt 144480 gacacttgaa tttcgtcgcc agaaatgtaa tctatatatt gctcccatgt aatatagaaa 144540 tgtgctaaat cgccgtcttt agtttcagga taatcacgcg caaggtcgca cactacaata 144600 tgactacgac ctggaagtaa tgtaggcaat gactggaacg ttttagcacc cataatcata 144660 gttgtgcctt cggtacgagc tttaaaattt tggaggtcct ttttaactcg tccccatggt 144720 aaaccatcac ctaaaccgaa tgctaattca ttaaagcctt cgaccgtttt agttggagaa 144780 taagcgaata ccaatttaat cattacgcaa aacccctttc aataaaccat tcagtggctt 144840 tattagcatc aaagaataat tcttcatatg tcttttcttt gttttcaaag actgtcacac 144900 aaacgcgttg acattctccg cagtattctt ctgacatact caaagcatca gaaaacattt 144960 cattaaattc atttaaatca ggattatgca atgcgttaaa aattgcataa tcgaattcat 145020 cattcataaa ttcaaataca aaaatcatat tatctcctaa tataaaggat cgggaacata 145080 tccactggct ttaatcattt taattaacgt tagcagtcct ttattaactg cttgtgagat 145140 ttcatcaaaa acttcatcac taaaaagttc taacacgccc ttctgaactt ttaatttaca 145200 accaataatt tcgtcatcgc ctatagtaaa ttcgtttccg ccaattccac cgaaaaactt 145260 aattacgcca gttaactgtc ttccacgaga atatgggtcg tgtgataaag taatatgagt 145320 caccccaggt acagttttaa attggcagcg aatgtttact tgggaaattc cagttacgtg 145380 aatgtcagac ataatatttt cctcaaacag actttttcac aattttccaa tcagctttaa 145440 actgttcaac gtcagaatga taaatccaga atcctgcgct ttctccatcc tcataaagag 145500 ggcacccatc gcattcatct tcccatccca tatcacgcaa aagacgttca gctttttcaa 145560 caagttcaga atctttaccg atgatattaa aataccattt acctctaact tctgaatctt 145620 taatgctctg acgttgtaat ctcattttat tctccttagt tgatagggta atagtatcac 145680 actactaccc ttctgtaaac tactttttga aagtttttcg caaaagttca atgatttcat 145740 ctacattgtt ttcgtctaca atgcagtgaa tttttgttac gccagaaatc ttgtctttga 145800 cttcatcttc ttcagaagtc gattctttat actcacgaaa acaatgaaat tcatcttcac 145860 aaatttctaa aagtctatct ttgaggtaaa aatgttttcc atttgcgcat tcaatgtgtt 145920 ttactgcttt atatccatta gcgacggaaa cttctttaac ttcaaaccat ccgccattat 145980 ctcgaatagc tttaactatt gatgaattag aacgtgggct ataattaata aatgtatcaa 146040 taagtcttgg aacaagttca tactttctac cagtatacat tgtgtttcct cattttaata 146100 ggggcttgat agccccttaa taattattgt tcgatcagtc ccatgtaaaa ttctgcgtct 146160 tcagaatcca tgccgtcaca atactcattg gccataaagc gggtgaggtc ttcaagagga 146220 ccttcaataa cgatttgaat actccaaaac ttagaatctt gtacgcttgt gatactaagt 146280 tcaggataac gattacgaat aatttcttca atatattcga aatcaacaat gtcaatatca 146340 actttagcca tattattttc ctctttaatc gtcagcagta ttgccgatag ttgtatagta 146400 ccatagaaga acagagatgt aaacagtttt gtgaaaaaaa tttttttgaa ataaaaaagg 146460 ggacctctag ggtccccaat taattagtaa tataatctat taaaggtcat tcaaaaggtc 146520 atccaggtcc gtgtcatcag cactagatga actgccagag cttgagctca taaaatcatc 146580 ttcagttttt gttttgaagt catcaacatt gaatgcatcc aaatcatcag caactttatc 146640 agctttctta gcagcagttg ctgcggcacc gcccatagca gcagttccca taacttgact 146700 gaacttagtg ctcaattctt caaacgattt gaatttatct ttagaagtca tttcagaaag 146760 gtcaaccatt tgttcgaaca gttctttctg gaaagattca tcatcaatgt ttggaatcgc 146820 agattgattc aggaatttag attcgtcgta gttactaaaa ccagaaactt gtttaacttt 146880 cagtacaaag ttagcacctt cccacggaca agttacatca accggagttt cacccatttc 146940 aacatcaact gcaatcattg cgttgatttt atcccagatt ttcttaccga agcggtattt 147000 aaatacttta ccttcatttt ctggagcagc tgggtctttt actacaagaa tgttagccca 147060 gtaagaagtt ttacgtttaa caagaccgta ctctttattg tcagtgttgt acaaatcatt 147120 tttactgatg tactgacata ctgggcaaga atcgtaatca ccgtgggtag atgaacagtt 147180 ttcaatatac catttaccat ttttcttgaa accgtgattt acaagaattg cgaatggtgc 147240 ttgttcatca tttttagacg gaagaaaacg aattactgct tgaccgttac ccgcattatc 147300 gagtttcagt ttccactcgc ctttatcttc agaagaaaaa ccacctttat ttccagccag 147360 tttagccatt tgtgcagcga gttcagcagt agatttacgt ttaaacattt ttatttcctt 147420 tttaatttaa ttaacagttg gtgctatgac gatgtatgac ctcatagctg gtcagtgaga 147480 taattataat ctatttataa taagcaatta atacttgcaa gatttcacag tttcaatgaa 147540 aacacttttg gctttctgtg aatcaatatt taaaattttt ctataagctt ttaactttat 147600 agaataatta ttccagacta aattatcagt ctgttcatca tgtttatcaa ttatatttaa 147660 aaacgaatca agcaagataa acgtctcaaa cgaaattata ttcgattgaa gtagtttaaa 147720 aatataactt gattgaactt ttggattata ttcaaaaatt tctttaaaag cagaaacttc 147780 aactttttta ctaaaatagt aaatattgcg aatatcttct tcaaacttaa atttaatttg 147840 ctttaagcgt ccgatatatt cacgataaaa cacaagtgca tcagcgtcag agatgtcacc 147900 aatccaagca tcctggttag caaccagatt gcttataaag attaaagcaa gttcctttaa 147960 tttatatttt tctgataact tctggaaaaa atacttatcc cttcgctttt gataagcggc 148020 atcagacacc cgcatgcacc aattatactt aattacatca tactttccat tcatatgttg 148080 ttttatcatt aagtataatt tataaactga tttaccatca atatatcttt caccaccagc 148140 aggcatgcgg agtttaatca tagcagaaaa tctaatgtat tagttttttc acaacgaaca 148200 acagaaggac gtaaaagatt ttcgtcaata gcttctgact gaattttttc gattataccc 148260 gaaggaataa atttagcaaa ttgagtttca ggaatagaat tttcttctaa gaatgctgtt 148320 gtagcttcaa gataactcat tccaaactct tctaccattt tttcaataat aaatccattt 148380 tcttgacgat caagaagctt tgttatttca tccttttctt tcttgattga aagttctttt 148440 tctgaaagac cggtctcatc gaccggacga atatcattta gagaaaactg tgtcataaag 148500 ttcaactacc tcttcagttt cagcttcaaa cacatcacgg ttatctttat gatacaaagc 148560 taatagacga ttaaacatct taccatcaac gccaagttca tctttggcac gaattcgaat 148620 atctttaatc agttcattat aaccggaaat tttcagttta tgatcagatg cttctttaat 148680 aaatttagcc aagtcttcgc catggatagc ttcatcaaat tcaaccattt cttttttagc 148740 cattattcac ctcaaaattc attaatgcta ttagttaatt tagaaagacc cgcttttaca 148800 aaatatgaat aaattttgcc acgcggtggt aatttatatg aattatagta attcacaatg 148860 tttgaagcaa tattatcagg aatataatca aaatcaatta gaactaaatt ttctttataa 148920 cgattatatt cagattctgt gagaagcacc ttagcttgct cacggtcatt agcaatggct 148980 tcaacgattg aagttttcat tgaaggagtt cgttcacctt caactttggt aaaccaaaag 149040 tcagatcgca ctttaactga agcaacgtta tcctttttgt cgcctttaag gattttagtc 149100 atacagtcaa tttcagcaga accgctttta attttaaccc atttcttgtg catcggtgac 149160 cattgcttaa catttgggta tttgtgaagt tgagtaaagt caccatccga tgaaatgatt 149220 aaaatcttat gcccttctaa agagaacttt ttaacaagaa cagcaatatg gtcatctgct 149280 tcatacttat caatatccat aacgatgtat ggcatataag ctttcaattc atctataact 149340 ttatgactgg attcaaaata accttcccag tcccaagtag attcttctcg tgcttttcca 149400 cggtttttct tataataata ggcgaaatca cgacgccaat atccagattt cgcgttatca 149460 atacacagta caattttagt gtatccaagc gtttttgctt ttttgacatt aaacttaatt 149520 gagttcaata tcaaatgacg aaccattgat aaattaattt tttctttatc tggaaagttt 149580 actagagcag tcgaaagtgc aatttgacta aagtcaatta agcaaattcc ttctttgtaa 149640 tcttcatcca gcatcatttc taaatccata tgaacctcgt tcaattagtg agatttctat 149700 tatatactat ccaaatctta aagtaaacaa gtataaatac ttattattga aaacacaata 149760 ggagcccggg agaatggccg agattaaaag aaagttcaga gcagaagatg gtctggacgc 149820 aggtggcgat aaaataatca acgtagcttt agctgatcgt gccgtaggaa ctgacggtgt 149880 taacgttgat tacctaattc aagaaaacac agttcaacaa tatgatccaa ctcgtggata 149940 tttaaaagat tttgtaatca tttatgataa ccgcttttgg gctgctataa atgatattcc 150000 aaaaccagca ggagctttta atagtgtaca atggagagca ttacgtactg atgctaattg 150060 gacaactgtt tcatcaggac cttatcaatt aaagtcaggc gaatcaattt cagttgatac 150120 tgcagctggt aatgacatta catttacttt gccatcttct ccaattgatg gagatactat 150180 cgttcttcaa gatattggtg gaaaacctgg tgttaaccaa gttttaattg tagctccagt 150240 gcaaagtatt gtaaacttca gaggcgaaca agtacgttca gtactaatga ctcatccaaa 150300 atcgcagata gttttaattt ttagtaatcg tctgtggcaa atgtatgttg ctgattatag 150360 cagagaagct gtagtcgtaa caccggcaag tctttatcag gcgcaatcta acgattttat 150420 cgtgcgcaga tttacttcag ccgcggcgat taatattaaa cttccgagat ttgctaatca 150480 tggcgatatt attaatttcg tcgatttaga caaattaaat ccactttatc atacaattgt 150540 tactacatac gatgaaacaa cttcagtgca agaagttgga actcattcca ttgaaggccg 150600 tacatcgatt gatggtttct tgatgtatga tgataatgag aaattgtgga gattgtttga 150660 cggggatagt aaagcacgtt tacgcattat aacaactaat tctaatattc gtccaaatga 150720 agaagtcatg gtatttggcg cgaataatgg aacaacccaa acaattgaac ttcagcttcc 150780 aaccgatatt tccattggtg atactgttaa aatttccatg aattacatga gaaaaggcca 150840 aacagttaaa atcaaagctg ccggtgaaga taaaattgct tcttcagttc agttgttgca 150900 attcccaaaa cgttcagaat atccgcctga agctgaatgg gtgactgttc aagaattagt 150960 ttttaacggt gaaactaatt atgttccagt tttacaactt gcttatatag aagattctga 151020 cggaaaatac tgggttgtac aacaaaacgt tccaacagtt gaaagagttg attctttaaa 151080 tgattctact agagcaagat taggcgtaat agctttagct acacaagctc aagctaacgt 151140 cgatttagaa aattctccgc aaaaagaatt agcaattaca ccagaaacat tagctaatcg 151200 tactgctaca gaaactcgta gaggtatcgc aagaatagca actactgccc aagtgaacca 151260 ggatactaca ttctcttttg ctgatgatat tatcgtcact cctaaaaagc tgaatgaaag 151320 aactgctaca gaaactcgta gaggtgttgc tgaaattgct acgcaacaag aaactaatgc 151380 aggtactgat gatactacaa tcatcactcc taaaaagctt caagctcgtc aaggttctga 151440 atcattatct ggtattgtaa cctttgtatc tactgcaggt gctactccag cttctagccg 151500 tgaattaaat ggtacgaatg tttataataa aaacactaat aatttagttg tttcgcctaa 151560 agctttggat cagtataaag ctactccaac gcaacaaggt gcagtaattc tagcagtcga 151620 aagtgaagta attgctggac aaagccaaga aggatgggca aatgcggttg taacgccaga 151680 aacgttacat aaaaagacat caactgatgg aagaattggt ttaattgaaa ttgctacgca 151740 aagtgaagtt aatacaggaa ctgattatac acgtgcagtc actcctaaaa ctttaaatga 151800 ccgtagagca actgaaagtt taagtggtat agctgaaatt gctacacaag ttgaattcga 151860 cgcaggcgtc gacgatactc gtatctctac accattaaaa attaaaacta gatttaatag 151920 tactgatcgt acttctgttg ttgctctatc tggattagtt gaatcaggaa ctctctggga 151980 ccattatacc cttaatattc ttgaagcaaa tgagacacag cgtggtacac ttcgtgtagc 152040 tacacaagtt gaagctgctg caggaacatt ggataatgtt ctaataactc ctaaaaagct 152100 tttaggtact aaatctactg aagcacagga aggcgttatt aaagttgcaa ctcagtctga 152160 aactgtagct ggaacgtcag caaatactgc tgtatctcca aaaaatttaa aatggattgt 152220 gcagagtgaa cctacttggg cagctactac cctggtaaga ggttttgtta aaacttcatc 152280 tggttcaatt acattcgttg gtaatgatac agttggttca acacagtcat tagaattata 152340 cgagaaaaat agctatgcag tatcgccata tgaattaaac cgtgtattag caaattattt 152400 gccgttaaaa gcaaaagccg tagatagtaa tttactggat ggtctagatt catctcagtt 152460 cattcgtagg gatattgcac aaacggttaa tggttcacta accttaaccc aacaaacgaa 152520 tctgagtgcc cctcttgtat catctagtac tgctacgttt ggtggatcag tttcagcaaa 152580 tagtacacta accatttcta atactgatgg aacagcaact cgtctgattt ttgagaaagg 152640 acctcaaact ggaacgaacc cggctcaaac gatgacagtc agcgtgtggg ggaatcaatt 152700 tagtggggaa tcaaacacaa cacgttctac cgtatttgaa gttagtgatg aaacatctta 152760 tcacttttat tctcaacgcg ataaagatgg taatatagca tttagcatta atggtactgt 152820 aatgccaata aatgtgaatg ctttaggttc tttgaacgcg aacggcgttg caacattcgg 152880 tagttcagtt actgctaatg gcgaatttat cagtaaatcg tcgaatgctt ttagagcaat 152940 aaacggtgat tatggattct ttattcgtaa tgatgctgct aacacctatt ttatgcttac 153000 tgcatctggt gatcagactg gtggatttaa tggattacgt ccattatcaa ttaataatca 153060 atctggtcag gttacaattg gtgaaagctt aatcattgcc aaaggtgcta ctataacttc 153120 aggtggttta actgtcaact cgagaattcg ttctcagggt actaaaacct ctgatttata 153180 tactcgtgcg ccaacatctg atactgtagg attctggtca atcgatatta atgattcagc 153240 cacttataac cagttcccgg gttattttaa aatggttgaa aaaactaatg aagtgactgg 153300 gcttccatac ttagaacgcg gtgaagaggt taaatctcct ggtacgctga ctcaatttgg 153360 taacacactc gattcgcttt accaagattg gattacttat ccaacgaccc cagaagcgcg 153420 caccagtcgc tggacgcgta catggcagaa aaccaaaaac tcttggtcaa gttttgttca 153480 ggtatttgat gggggtaacc ctcctcagcc atctgatatc ggtgctttac catctgataa 153540 tgctataatg gggaatctta ctattcgtga tttcttacga attggtaatg ttcgcattat 153600 tcctgaccca gtgaataaaa cggttaaatt tgaatgggtt gaataagagg tattatggaa 153660 aaatttatgg cagagtttgg acaaggatat gtccaaacgc catttttatc ggaaagcaat 153720 tcagtaagat ataaaataag catagcgggt tcttgcccgc tttctacagc aggaccatat 153780 gtcaaatttc aggataatcc tatcggaagt caaacattta acgcaggtct tcatttaaga 153840 gtttttgacc cttctacggg agcattagtt gatagtaagt catatgcttt ttcggcttca 153900 aatgatacta catcagctgc ttttgttagt ttcatgaact ctttgacgaa taatagactt 153960 gttgctatat taactagcgg aaaggttaat tttcctcctg aggtagtatc ttggctaaga 154020 gccacaggaa cgtctgcttt tccatctgat tctatattgt caagatttga cgtatcatat 154080 gctgcttttt acacttcttc taaaagagct attgcattag aacatgttaa actaagtaat 154140 agaaaaagca cagatgacta tcaaactatt ttagatgttg tatttgacag tttagaagac 154200 gttggagcta cgggatttcc taaaagaaca tatgaaagcg ttgagcaatt tatgtcagcg 154260 gttggtggaa ctaataacga aattgcacgt ttgccaactt catccgcgat aagtaaactc 154320 tctgattata atttaattcc tggcgatgtt ctttatctta aagcacagtt atatgctgat 154380 gccgatttac ttgcgcttgg aactacaaat atatctatcc gtttttatga tgaatcgaat 154440 ggatatattt cttcaacaca tgccgagttt accggacaag ctgggtcatg ggaattaaag 154500 gaagattatg tagttattcc agaaaacgca gtaggattta cgatatatgc acaaagaact 154560 gctcaagctg gtcaaggcgg catgagaaat ttaagctttt ctgaagtatc aagaaatggt 154620 ggaatttcaa aacctgctga atttggcgtc aatggtattc gagttaatta tgtctgtgaa 154680 tctgcttcac ctccggatat aatggtactt cctacgcaag catcgtctaa aactggtaaa 154740 gtgtttggac aagaatttag agaagtttaa attgagggag ccttcgggtt ccctttttct 154800 ttataaatac tattaaaata aaggggcata caatggctga tttaaaagta ggttcaacaa 154860 ctggaggctc tgtcatttgg catcaaggaa attttccatt gaatccagcc ggtgacgatg 154920 tactctataa atcatttaaa atatattcag aatacaataa accacaagct gctgataacg 154980 atttcgtttc taaagctaat ggtggtacat atttaaataa agtaattttt aataaaggaa 155040 tgactgttcc tggtgcaggg tcaggtgaca atggtatttt tgctggtcct ggtgatagtg 155100 ccacgtatga tactacaaat atggatattg tttcgtggta tggtgttggt tttaaatcat 155160 cacaaggaac agcaggtaga actgtagtaa ttaacacacg aaatggagat attagctcaa 155220 agggcgtaat tgaagcatca caaatccgtg taacttcgtt atcaccagta aataattatg 155280 accttacgcg gaaagattat gttgatggag caataaatat tgttacagca aacgcaaact 155340 ctagggtatt acgctctgga gacactatga taggaaattt aactgcgcca aacctttttt 155400 cacagaatcc tgcatctcaa ccctcgcatg ttccacgatt tgaccaaatt gttattaagg 155460 attctgttca agatttcggc tattattaag aggacttatg gctactttaa aacaaataca 155520 atttaaaaga agcaaaactg caggagcacg tcctgccgct tcagtattag ccgaaggtga 155580 attggctata aacttaaaag accgtgtact ttttactaaa gatgaccaag gaaatattat 155640 tgatctgggt tttgctaaag gcggtagtat tgacgggaat gttattcata caggcaatta 155700 taaccaaact ggcgattata ctttaaatgg tgtcttcact cagactggta attttaattt 155760 aactggtatt gctcgagtaa ctcgcgatat tattgccgct gggcagatta tgactgaagg 155820 cggagaactt attacaaaaa gttcaggtac agcgcatgtt cgttttttcg ataacaatag 155880 tcgcgaacgc ggaatcattt atgccccggc taatgatggt ttaactacac aagtacttaa 155940 tatcagggtt caagactacg ccgctggtag cgaaagcact tatgcatttt caggcagtgg 156000 actatttact tcacctgaag tatcagcatg gaaatctatt tcgtctccac aaattctaac 156060 caacaaagtc attactaata ataaatctac gggtgattat gacatctatt cgatggcaga 156120 caatgttcca ttgtctgaaa gcactactgc tattaatcat cttcgtgtca tgcgtaatgc 156180 cgttggttct ggtattttcc atgaagttaa agataatgat ggaataactt ggtatgcagg 156240 tgatggactt gacacctatc tttggtcatt tacttggagc ggcggaatta aatcgagtca 156300 ctcaatttct attggtttaa cacctggtaa taaagattat tcaatattag gaccatctag 156360 tattgcttta ggagataatg atactggatt taaatggcat caagatggat attattttag 156420 cgttaataat ggaacaaaaa cgtttttatt tagtcctagc gaaacaacta gcctaagaaa 156480 atttgtagct ggatattcta ctaacggaac cgatttaact actcctccaa ctgaaaacta 156540 tgctctcgct actgtcgtga catatcacga taataacgcg tttggagatg gtcagactct 156600 tttaggatat tatcaaggcg gtaactatca tcattatttc cgcggcaagg gtaccacaaa 156660 cattaatact catggcggtt tgttagttac tccaggtaat attgatgtta ttggcggttc 156720 tgttaatata gatggtagaa ataattcttc tacactaatg tttagaggca acacaacagg 156780 atacagctcg gttgataata tggatattaa agtttggggt aatacgtttg ttgacccaag 156840 cggaggtatc cgtaaaaaca ttatggaaat ttctgatgca actagctgga tgagctatat 156900 tcaaagactt actactggcg aagtagaaat gaacgttaat ggttcatttg aatcatctgg 156960 tgttactgct ggagatagag gagttcacac aacaggtgaa atttcatctg gggctgtgaa 157020 tgcgcttcgt atttggaacg cagattatgg agctattttt agacgttcag aaggcagtct 157080 tcatattatt ccaactgctt acggtgaagg taaacatggt gatatcggtc cacttcgccc 157140 gtttagtatg gctttagata ccggtaaagt tactattcca gatttacaat caagttacaa 157200 tacgtttgct gctaacggtt atattaaatt tgttggtcat ggagcgggtg ccggcggtta 157260 tgacattcaa tatgctcaag cggctcctat tttccaggaa attgatgatg atgctgtaag 157320 caaatattat cctattgtta aacagaagtt tttaaatggt aaagctgttt ggtctttagg 157380 tactgaaatt agttcaggta cattcgttat tcatcatctg aaagaagatg gttcacaagg 157440 ccatacgtct cgttttaatc aagacggtac tgttaacttc ccagataacg tttctgtcgg 157500 cggcggtgaa gctactattg ctcgcaatgg taatatctgg tctgatatct ggaaaacgtt 157560 tacttcagca ggcgacgtaa ctaatattca cgatgcaata gctactcgtg ttgctaaaga 157620 aggtgatacg atgaccggta ggttgacttt atctgctgga aatgatgccc ttgttttaac 157680 tgcaggcacg ggcgcttcat cgcacatccg tagtgatgta ggtggtacaa ataattggtt 157740 tataggcaaa ggcggcggcg acaatggtct aagtttttac agttacatta cacaaggcgg 157800 tgtgaacata acaaataacg gcgaaatagc gctttctcct caaggacaag gagcgtttaa 157860 ttttaataga gaccgccttc atataaacgg tacacaatgg accgcacacc aggctggcga 157920 ttggggaaat caatggcgcc aggaagctcc tgtatttgtg gattttggta atgtcggtaa 157980 tgatagttat tatcctatta ttaaaggaaa atctggtatt actaatgaag ggtatatatc 158040 tggtgtagat tttggtatgc gacgcattcc taataactgg gcacaaggta ttattcgtgt 158100 aggtaatcag gaaaacggtt ccgacccaca agctatcttc gaattccacc ataatggaag 158160 catgtacgtt cctgacatgg ttaaagctgg agtaagaata tcagctggtg gaggtgaccc 158220 tgcatggaca ggcgcatgtg ttgttattgg tgataatgac accggattag ttcatggtgg 158280 tgacggccga atcaatatgg ttgccaatgg tatacatatt gcaaactggg gagcaggcta 158340 tcaatctcat cctgggcttt gggattcaac cggtgctttt tggacagaag ttggaagagc 158400 tatcgtttct catgggcatc tcgttcaggc aaatgatagt tattcaacgt ttgtccgtga 158460 tgtttatgtc cgttctgata ttcgtgttaa aaaagacctt gttaaatttg aaaatgcttc 158520 tgagaagctt tctaaaatta acggttacac ttatatgcag aagcgaggcc tagatgaaga 158580 aggtaatcag aaatgggaac ctaacgccgg tttgatagct caagaagttc aagctatttt 158640 gcctgaatta gttgaaggtg accctgatgg cgaagcttta cttcgtttga actataacgg 158700 tgtaattggt ttaaatacag ctgcaatcaa tgagcatact gcagaaattg cggaacttaa 158760 atcagaaatt gaagaactta aagcattagt taaatcattg ttaaaataat aagaggggct 158820 tcggcccctt ggaggtttat atggcagtaa caggaccgtg ggtaggatcg tctgcagtag 158880 ttaatacagg acaaaattgg atgggtggtg ccgcgcagag attgagaatg ggaattccgt 158940 tttggatgag taatatgata ggtcgatctg ttgaaataat tcacacgctt ggagcagacc 159000 ataacttcaa tggtcaatgg ttccgagata gatgttttga ggcaggtagt gcacctatag 159060 tgtttaatat tactggagat ttagtatcat attctagaga tgttccttta ttcttcatgt 159120 acggagatac acctaatgaa tacgttcaac tgaacataca cggcgtaacg atgtatggtc 159180 gtggtgggaa tggttgggcc gctggtgcaa ttggagcatc tgatggcggt gtatgtatcc 159240 agaatgatat aggtggacgt ctgcgaatta ataatggcgg agctattgcc ggtggcggcg 159300 gtggcggcgg tggttattca caagccaaca actgggcggg aaaatatgtt tgtggtggcg 159360 gtggcggtcg tccattcggc ttaggcggaa ataatggtgc tcgatggcct ggtggtaatg 159420 ctagtttgac gtctccgggt gccggcggta atactggtac agggtattat gcaggtggcg 159480 gtggtgaagt tggtcagcca ggacaatatg ctaatccagg tgctggttat tcaacacctc 159540 cgacaagtcc tggtgctgct gtagcaggat cagctccaac atggcagaat gttggagcaa 159600 tatatggttc aagagtataa tttgaataaa tatccttaaa aggagggtct atggcagcac 159660 ctagaatatc attttcgccc tctgatattc tgttgggtgt tctagatcgc ttgttcaaag 159720 ataacgctac cgggaaggtt cttgcttccc gagtagctgt cgtaattctt ttatttatga 159780 tggcgattgt ttggtatagg ggagatagtt tctttgagta ctataagcaa tcaaagtatg 159840 aaacatacag tgaaattatt gaaaaggaaa gaaatgcacg ctttgaatct gtcgccctgg 159900 aacaactcca gatagttcat atatcatctg aggcagactt tagtgcggtg tattctttcc 159960 gccctaaaaa cttaaactat tttgttgata ttatagcata tgaaggaaaa ttaccttcaa 160020 caataagtga aaaatcactt ggaggatatc ctgttgataa aactatggat gaatatgcag 160080 ttcatttaaa tggacgtcat tattattcca actcaaaatt tgctttttta ccaactaaaa 160140 agcctactcc cgaaataaac tacatgtaca gttgtccata ttttaatttg gataatatct 160200 atgctggaac gataaccatg tactggtata gaaatgatca tataagtaat gaccgccttg 160260 aatcaatatg tgctcaggcg gccagaatat taggaagggc taaataatta tttgttcgta 160320 tacatctcta gatatcgata tacaccctca aaaccctcgt tgaattcgtc gatgagggtt 160380 ttcttatctt cctgagttaa ttcagaaaca attttacgga atgaattctg atttaacttt 160440 ctaccttcat gcgttactcc aatctcattc agaaatgcaa taaaattagc acgattttca 160500 acaatatctt ctctggaaaa tttaatcaaa atagacgcaa cagtaataat ttcacgaact 160560 gtatcaatgt ttttattcat taactatacc actcaattag ttgactttgt tataatatca 160620 tcagacgctt gatttgtaaa ctggtctgtg ttattttctt caaaaatttt ttctacgaat 160680 tccttgaacg actcacgttc ctgagctgca ttatgctcga ttaccttttc aagattatga 160740 ctcattcgaa ataatcttca atttcgtaat catggacgta aatcattata gtttttaata 160800 catcatcaat actttttcct ggagctggaa ttacgtaaaa atatcctgct tttgggaggt 160860 ctttataagt tccaattaag aaatcattat tctcaagatg cagttcttca actaattcat 160920 cgacaattga gtggtataaa tttggtagaa acttatatag cttttctaga atgtcaattt 160980 tgattgtata ttgaaccaca gattgagaat caataatcat agaccttccc cttatgtttc 161040 tgtttgcgat tagattcttt aaacgctttc ttcttatctt tatgaacaga agctttatta 161100 aaattatgtt ttgcgactaa attgttcata gtgctgaatt acctctctta aacatttgca 161160 tgtgaatgaa aactttttag ctacaccaca ttcaaatata tgttctctta aatcacgtgt 161220 gtcagtatat cccatctcaa caataaaatg ccgtattaga tttttatctt tatcattgag 161280 agagttaaaa taatcggatt ttgaattaat ttccctggcc aaattgaatc acctccagtt 161340 gacgttttag ctcttttatc atctcttcat tcatcgcaat ataaagatcg cgtaaagcag 161400 gttttaacat tccatttatt ggagaactaa atgggcatac ataatctttt cctacgagct 161460 ttttagtgaa ttccatatca caaaactgaa atgcaggttc attagcataa attccccaat 161520 tagttgacat cattttattg gcatattcta atgcctggat ttgattagta attccatcaa 161580 tttgaaactt tttaatattc attagtaaag gtcctcagag taaagttctt tttcactacc 161640 accacgttca atacgtactt gtccagcgta agttgcaata atcattgctt cttcacgtgt 161700 ccaataatta ctatattggt caataaaccc ttgatcatca tcacaaactt gctgagtaac 161760 taattgaggt ttaactacat ctaaaactgc tgccatatct ttagaataat gacgagcacc 161820 cggaataata agagttcgtc catcttttaa tttaaaacgg ttggctgcgc aaacaattcg 161880 tcgttgatac ttttggtttt catcccagta tgcggtttgc caacagattt caggaacttc 161940 tgcaagaata tcttcttctg tgcatttata accatgcgct ttaaattttt gaacaagact 162000 ttctggagtc tcacgagata aaggaacatt cagcattttt aaacgattaa taaatggatt 162060 catttaaacc atcctttaat acgttgccac aaagttttct gttgagcttt gttaacacca 162120 attgagcgaa taactggttg agattcctgg aattctttat aatcagcaag gtaaatttcg 162180 taagctgaat ccgtaaagga acttatagct gccatgaaat tattgcgaat acccactgga 162240 gcatctttac tttcacgaat aatcatgtat ttgccagtct taatctttac aatagttcca 162300 agataagccc catggtacca gatgtcccac ccctcttgag taggttctgc gcaacgacga 162360 agttcattaa caatttctaa cttgttcatt atttattcct cacagttcag atgctacggt 162420 gattacagct tcaatgtttt ctgctgagcg tttaatgtca agatacacat taccattttt 162480 agcgatttta catgacatac cgatatcagt aaatttctga atatgatgtt ccatcatttt 162540 gtatccaaaa attcgcatat ttccattgtt gttaatttca aaattacgaa ttccgtgagt 162600 gcgtttttct aaaatagcga gatagttact acgataagtt tcaacctttt taagaacaaa 162660 tccattttca tctaaaagtt ttaacatgaa gtctttatct tcttccatat cagaagtaat 162720 ctcgcgagct ttacgagttg ctcgtttttt cagcagttcc ggagcgtttt cctgtgcgta 162780 taaagttgct gcatttgaaa taatatcctg agcttcacca gtaatgatta atccatcacc 162840 agatttctct accaggcctt ttttaatcaa taccccaata ttactattaa ctactgcatt 162900 acctaaatct ggatgcacct cacgaacttc tgcagctgta atgaaatctt tcttagcaat 162960 agtaattaaa atcgcagcag ttttttcatt cagaatatcg ttagaagctt tgatgatgta 163020 agttacttta gacattttct aatctccgta attctgtatc agtagttgat agttgtatag 163080 taccacagta tgctttggtt gtaaaccgtt ttgtgaaaaa aatttaaaat aaaaaaggga 163140 gagcctcggc tctccctaaa attactgcat gacagttatc acagtcatga taacacgttg 163200 aatgccgaac gcaagaagac ctcccgctac agctggaaca acacctagac ccgctagtaa 163260 aatgctacca gatactaatg cagcgcttgt aataccaatg aatggactca tttgatttcc 163320 tctaaatctt tggtgtattc tgtaactaca tcagtagttt tccaatattc gttttcttct 163380 tttttagctt tagcttcttc agcaagtttc tttgcttcgt cggaagtcat atgaaaaata 163440 ttcattccga ctagtttatc aacataagaa gaatacatat caattttaga aagttcttcg 163500 gtcagttctt tgcgagtttt accctgcaca acaatttcac ctgaaattac tttcttaatg 163560 aaatgtgcct tggcaaaggc taaacgaaat gctgattcag tttctttgat tttgttatca 163620 attcgttttt ggacataagt tttacgaact tcaacaaagt ctttaattaa atcaactacg 163680 ttatcgtaaa cttgtagctt tcctttctca ttaatgactg taatattctg agaacgacgc 163740 tcaatcaacc caaagtcttt cataattttt gcatgacgtt cttcttcgtt atcactcaaa 163800 gagtattctt tgcggaattt aactttaaag ccaaagccat gctcaccgca agcatcatcc 163860 catgtaatga agcctttatc ttcaagcggg tctaagattt tactcacgta agtttcacga 163920 tcatacttat acggaatctc agtgatattc atttgagttc gtgaagtaaa cttatatgtt 163980 ccacgaattt catattgccc gtcaatctca acgacttcac cgcgaaattc tgggaattct 164040 actttcggtt tagttacttt ctttccttga agagcttgta atacagcttt cttaacagaa 164100 gaaacactat gaggaagaat gtaagttgca taaccagttg caataccgga aacaccatta 164160 agaagaacag taggaataat aggcaaatag aaagcaggag gaatgtgttc tttatcttga 164220 tgtaccggag catattcagt atctttatat acgttataga aatttttact tacacgagca 164280 aaaatataac gacttgccgc tgctttttga acagtacgag aaccaaagtt tccttgacca 164340 tctaacaaag gaaagttatt attccatgta ttagccatca aagcccccgc atcttgtgca 164400 gagttttcac cgtggtgata cccaaggtca gctacaccac ctgcaataga agcaagtttg 164460 tgaaacttat ctttatttcc ccgtgccaaa tcaagagctc gagcgataac aaatcgttga 164520 actggcttaa atccatcaat catatttggg atagcacgat tttcaaccgt gtacatagca 164580 taagccaatg cttcattatc aatgatactt tttaaatcgc gattattcag ttgcataaat 164640 ttaccatact agtgaatgta gtgccataat aacatcagaa atgaaaagca cgacttgaat 164700 taatccgaac attactccat aatatagtgc taccaataaa gcagcaaggg ctactgagta 164760 gcccaagatt ttcttaatca ttagtagata acaacacaaa tgttaaatat gcacacatac 164820 cctgggctaa agcttgtgaa aacacactgc tagcatcaat acaaatagtt aaaacacatg 164880 ctactatcca acaaataaat gaaataactc ctaataattt tgcaatattc atattttcct 164940 cactagcgtc cgaagatgcc tttagtttta agattgttac gatagaactg cattacatgt 165000 tcgttatgga aattactcat tagtatgcct gcaaaacaaa tttaaagtta tcagccaaca 165060 tacgattcat ttcttcaagc gtttgatact cagaatgatg attacgagta aacgctaaag 165120 ctaactgacc ttttccaaat cccgtcgtca gaggtttcat cttagaagca ggtagataaa 165180 atactgtgta tggaacattg ttatttgcaa tagtacgcgc aagctgagac cgacgctggc 165240 gaatatgact tagaactgca ctgaatcctt gcttagaacg ctgattacct acataaaatc 165300 gtgcagatac gcatcgacta ccaaatggac gaccatctaa tttactcgct aaaaagtaaa 165360 atccagggtt agacaaaatg tctttatgtg gagttccaaa aacccattca ccgcccttga 165420 ttgtaccaat aacagttgcg cctgcattat tcaaatcagt aacagtcata tatttcatgt 165480 taatttcctc taattatttt ctactccaag gccgcatgaa tacacacggc cgataaatta 165540 atcgtcgcag tcgacgctca attcccagaa ctcttctaca gtataagttt cagtatcatt 165600 ttcaatacag aaacgttcat tactgttatt tgctaaagta gcgttaactg tcattttctc 165660 gctggtgctc ttaagaggcg aaatacgaat taactgatca ccattatcta agcaaaaaat 165720 ttcgccaact tttacatctt taaaaatttt cataattcac ctcaaggagt ataaaatcca 165780 aatgcagttg ttgaccatcc catccaatat gggggatatt tgcgccaatg taaaatacaa 165840 gaatataaaa ccaaatgctt agtaaattca ttattttaca ccattccaaa ttgtttcaac 165900 cacagatttt aaaccatttt ggtgaatatc cattccgaca accgccatca aatagattcc 165960 aaccacaact gaacccaagg caaaaatcag catgaaaatg aataaagctg gaaaaatatt 166020 atcgaaaaac cattccataa atgtaaaagc actacgttta cgcttcatat tttcctcaca 166080 taaatccaaa gtaagcgttt aatacatcaa tcattaaaac gattgggaat atactcaaaa 166140 ctactagtat tataactaca ttccatatag ctttaacaat ctttttcatt ttctgttcct 166200 ccgtagttga tagagtaata ataccacaga ggaacagtct tgtaaacaac ttttttaaaa 166260 atattcgtaa taaatgtgaa taccaatcac tactgccgaa acttgcgcaa cccaccacgc 166320 acaagcaata agtacagaat ttaaaatttt cataataacc tcatcacaaa agtaaatgtt 166380 aaacaaatta atggaatact aattaaccaa acaaaacacc accataatga actcatagtt 166440 caatctcagc gattttcatt tcattactat taatagccgc tttaagacta tctgaaagaa 166500 ttacattcca gtggtcattc atatgaccat taactaagcg tgtaatttct tcgggagttg 166560 aaaaataagg cgtatcagac tcccaatgcg atagtcccaa gcgagtataa atcatacctt 166620 catcgtcgct agaatattca actgacacaa actcatcagt tattttatgt ttagcgtaat 166680 aaaatttaaa tttcattttc cgctcctccg tagttgatag ttgtatagta ccacggtcct 166740 tgtggtatgt aaaccgtttt gtgaaaattt ttaaatggaa agataccatc cattgtagtt 166800 gctttttctt acaaccttac gaaggtcttc tctgtcaccg atgaacttcg gagtgtactg 166860 gatgacacct ggatgaattt ctttagtgtt gaatataatt atacagtcag cgacttgatg 166920 attcagaatg ggccctagat ttattccaga accgtatgga tactctccgc tgcatccggt 166980 tgttaccgaa atccaacgtg agtcagtttg atgtgtctta acttctacac gaagcccgca 167040 gtatcttgga tgcgccaata catcccatgc atatgtatac gggtcatcga catcttcttg 167100 acctttgtta acatacccgc tcagccaatc tgctacaaaa aactctgcgt acacagcgat 167160 acggcatctt tcgataactt ctgccttatc ctgattcgga ttttgtttta aagagtatct 167220 tgctgtatca gcaattttga ccttcatttc actagtcaag tcaccgttcg atagggtaaa 167280 tgtcggaatc tgaaatagtc tctgtaaacc cggattcgtt ttctgcattt agactttcct 167340 ttttaccact gagataagcg ttatatactt taagagtgcc gtaataaatt cggtcatttt 167400 catctaaaga ctcgcggtca agttcatcga gctccttttt atccatgact ataacatcat 167460 tacagtaaag aaacccaagt ttttcgtgac caaactcaaa tttattacag tacacaatat 167520 tagcgtgatg atttccgtgc agtttaatct cttttatatc ggaatcaccg atattcatac 167580 aataaatcat aatttttcct taaaacaaaa gggccgaagc cctttatttt acttgaattg 167640 tgcaattctt ttctctagac attcagcata agatttcatt gagataaact gtgaaagtaa 167700 cagttcttgc tcaactgcac taactgttag aaactttgcg ctttctaaaa atttactcag 167760 tgcattaatt ttgagcatta attgatcgta ttcttctttt actcgtgctt gataacctaa 167820 cataattttc cttaatgtga taagggccga agcccttatt taaattgttc agtaacgtct 167880 tcaactactt cgtattggca ggtacgcatt ttagcatcgt tgtaatcaat cggaattgat 167940 actacatcgc gaggatgaac tttaactttt acaactcggc tggttgaact gccaaagtga 168000 cgaatataag atttagaaca cacatgcaga ccgcgagaac aagtttgcgt atcatcgtca 168060 ttcacacgag tacgtggcat tttaactact ttaccaggac tgttatcaaa ggtatttgag 168120 tgacaatcaa agtaattgct gcgaactact ttccaagcat agaagtaacc atcttctgta 168180 atttcaatat cgtttgctac caagaaatca aagagtcgag aaaccgcttt ctggcttggg 168240 ttttccagca gattttccaa gaacggaaaa taaaattcaa agttttcgcc tttttccatc 168300 gaatcaagaa tacgatcaac caaaccagac cgcaattcaa tattttgata gaacaagctt 168360 ccaccttcaa ttcgaacatc gccggaaata tatttttcaa cagcgcgacg aacattaatt 168420 ttttgtgctg cttcttctaa cttatctgct acaagcagat taagaatttc ctggaagttt 168480 gaatgagtat taggagttgc gttataagtt acgccatcaa cagtaattga aatgaatttt 168540 ttagatgcat tccaaataat gtcagattta gcaactggag caatagctgt atcgctatca 168600 actttaaccg taatgtcacc gctaatagta actttaggac gtttagcttc ttcagcattt 168660 ttcaaaacac gacggattgt gtcaaccgat acatccttcc aataagctaa ttcctgctgg 168720 gtgtaattac cgcttgaata cagtttgaca atttcagctt gttcgttttt ggtcaggcat 168780 ttaatattgt acataatttt cctta 168805                          SEQUENCE LISTING <110> Optipharm.CO., LTD   <120> Novel pathogenic Escherichia coli specific bacteriophage EC121        and antibacterial composition comprising the same <130> 34 <160> 1 <170> PatentIn version 3.2 <210> 1 <211> 168805 <212> DNA <213> bacteriophage <400> 1 ttaggccgca agggccttca tagttttagc gatttgggaa acttcatcat cactcaaaga 60 gctgcgataa ccgatgaagt cggaaacaat acggaatttc ttggtaaact cagcaaccat 120 tttatcactg ttttttgaag cattatttga taatacatca aaaagattag ttattgtcca 180 gatgtcatga ccgatggtat cttttccacc gttgaaatat acaccctgta atgaactaac 240 catattagcg agtcgtgtat attcttcaga aacttcatct atactgaagt acttcatcat 300 aaaatctaat tcaggatact taataatttt atcaatatat cgtttagctg aacttgaata 360 acctacatac ttatcataat ctacagcatc aaaagcatct acatataaat cacgtagagt 420 ttcaaaaata cattggcact gaccaagttc ttttaccttt ttctgtaaaa gtggacgaat 480 aacataaaat tcattaatgc caataagatt agccatacga gtcaaaatac tcgtagatgg 540 atgacaaagc gatgtagtac catccataga gaaaatatca gaacgatgca tatacgctac 600 ataaccagta atttcatctg cttctgatgt gagtgtaaac agttcctctt tttcccagcg 660 tccgtcttta atttcaaact taaatgcagt agcagcttta ggacgaggag ctttactttt 720 aactaccttc ggaatataac ttttaactaa agcttcaatt tctgacaaat aatgaatgtt 780 aacttcatca ctttcaaaca ttgccataat atcagggagt aaatcaatct gcgattctac 840 ttccggatta ataaacagaa gacgctcatt gtgatgaata tttaaagtgt tattaaattc 900 actatcatct aatgcacgtg ctaatccacg gataatatta acacgatttt taatattatc 960 aatgacgata ttaatttttg ttgtgttaat accaaacaaa cgatagcttg acgcaacggc 1020 tgaagtttca tgactttgct taatgcgttt cagtcgaggg tcaagattta cttcatacac 1080 aacccctgca ttgcataact tactgtcagg ttcaaacatg ctctgcatct tcttatatga 1140 cagattttta gtcgtgaatt tgaccgaatt actaatcata taatctcgag cagaataccc 1200 catcttcatc aattcacggt atgtatgacg aggagatgta gattctttaa atcgttttac 1260 atcttcatta aatgccttct cactgagttc tttaacacgc tcaataatat ttttacgagt 1320 acgatcatct aatgaaagag cctcacgcga tggagcaata tcaagtgaac ccattggaaa 1380 cttaatgtaa ttcacttcat tgcggatgct taaccagtta cggtctctaa taacaccatc 1440 aataggataa acaataccgc catagatagc gtacaatcca ccacgatctg gccaatatct 1500 ttctggattt acaccgtaat agtcatcaaa atccggaaaa taatcaattt cacggtcaag 1560 accattaatg atagccaaat ctttgaatgg tcgcatgata taagaaactt cataagcaaa 1620 gtttctaaag tctttttctt caactggaac tacgatttca ataccagttt tatcgtttgg 1680 acccatttct tttacgaatg taggtttaat ctgcggaccg tcaccatcca tgtaagctac 1740 ataaccgcga atttcacctt tatggtacga agtaatacta aacgtatcag tataactaaa 1800 cggagattta gaacctaaac caaatccacc aatgaaatcg ttagattcag ccttagatga 1860 actaaagtat gaattataca acccgggaga attatcatca ccttgaatat caaaatcgct 1920 catacctgga ccaaaatctc ggcaaacaaa tcgtggatct aaacgtccag gaacttgaat 1980 gataaatttt tcaggatttc cattgagagc atgggcatca atcatgttgg taatcaattc 2040 acggactact gcgcgaatct tgtttgtata caagtcagat gacagaattt taaatacttt 2100 aggagatgct gtgatgctaa atgcttttga tttagaacca ttaccaagaa ttgtttcttt 2160 ttcagtggtg ataatcataa tttcctcatt aattcatatt gcgtttaata acttcagcaa 2220 cttctagtag ttcatcttta gttgcggtgt cggattgaat tttatctcta atatccttaa 2280 agcggttttt aaactcttca gcttctccca tatcgaaaaa gcgttgaatg attctatatt 2340 ctcgatgaac tgctttatca aaaagttcta aatttacttt atatgatttc atttcaatat 2400 cctcatttgc ccaattaatt ataccacatc cttgtggtaa agtaaactac tggctcatcc 2460 attctttacg aaggtcagca ttatccccca tgagcatttc aaaaagctct ttccaattct 2520 caggaagttt aacaacatca tatactgggt tttgaatcat ctcacgatat tcagattttt 2580 ccaaagagcc aagtccctta atataacgga tgctatgttt aggtagagca tctttggcac 2640 tctcatattc agcgaccgta taaaaccatt cttgtttttt accgacctga gcgatgatta 2700 cgggagtttt gacgaagcga attcttcctt gttcaaacag ttctggccaa ttactaaaaa 2760 atccgagcag agaaggataa atgcttccta gaccatcgtg gtcagcatca gtcataatag 2820 caatattatg ataattcaag ttttcagcct tttcaccaag aactaatcca gtgattgcgc 2880 aaatatcaaa cagttctttg tttttaagca tatcagcata tgacataccc caactgttga 2940 gaactttacc acgtaatgga taaccgccat gaagttcttt atcacgaaca tcaataagat 3000 atccgatagc agaatcaccc tcagtcaaga aaagagtagt gtcagcgtct ttaccgcaaa 3060 gattcgcttt aatatgttta tgaaccttag ctttagaagc ctttttagct gctttagttt 3120 ctgctgcctt ttctgccgcc aatttacgag ccaaagcagc ttcaataatt ggcattaaaa 3180 ttgcttcatt atttaaaata gcacgtgaaa tctttttagc atcaagctga atatgactac 3240 gaatttcacc aaatggagaa gtcaaacgct ctttagtctg agaatcaaat cgcatgtttt 3300 tcatatcacg aacaaacata acgatagtca aacattcttt aacccgtgct ttagttacat 3360 caattttgaa cttacgtttg atttgtggaa taaggtcttc acaaatatca tccataacgc 3420 agtcaatgtg atggccgcca ttcttagtat gaatgttatt aacgtatgtt aattgacgaa 3480 aaccatccag tgaacgacca atcgcaatag aacaattttc ttgttcttga acgatagcat 3540 gctcatcata ttggcgtgcg tatttcttaa aattgccctg aaccttttta ccattaaagg 3600 taaattgaat atcaggataa actactgcaa gtgtctggag acgatctagt gtaatgtcaa 3660 gataaacctg agatagctca ttagtttcaa atgacataaa atcaggaatg aaagtaacac 3720 gagttccttt ccattttcca ggaatagttt cccatgattt attttccatg ccatttgaac 3780 aacgaactac aatattattt tgaccatcgc cagtttcacc gacaaacatc acagaaaaaa 3840 tgttagttaa actagaacca acaccgttca taccgccagt gacgcgttct ttatcatcac 3900 cgaagttacc acctgctttt ggaatagtcc aggcggcaac aggaccagga atttcttcgc 3960 cagtaggtgt tttaaccatc gcttgtggaa taccacgacc gttatcttca acagttactt 4020 gattgttttt aatagtaaca ttaattttat tcgcgaattt aaacttagta cgaatacctt 4080 catctaccga gttatcgata atttcatcaa taagcttaac aagaccaggt acatactgaa 4140 cactttccca tttaccaaac agaaagcgct catgcatttc attagcggaa gagccaatgt 4200 acatgccgct acgctttttg atatgttcaa tatcgctcag aattttaatt tcattcttaa 4260 tcatcactta tcctcgtttg gtttcgggaa tattatactc cggtaatcat aaagctaaag 4320 gcccgaaggc cttttattta aaacggatag tcgaatcctt gaagaataga ccagaacata 4380 cggttccttc tactttctgc ccggtaggtc caatagcacg aaatccagta tgttggaaat 4440 cattttcaga gcaaccgaac caattgtatc cagtgatttc aatattagta aaaccacttg 4500 aagataaaac tttggttgca ttatcagcat cagtacatcc tgctaaagac actgctaata 4560 ctaatgctgc gatagaacga ttaatatatt tcatagtttt cactcaaatt taatggcttg 4620 aaggagacta ataattctca agcgacttct ttcatcttta actgtaaaag aaagagggtc 4680 gccagatttc atagtgatag tgcattcaaa atcaaaatct tcaggaactt cttcgaagaa 4740 gtcaaattct tcatcataaa ttagaacttc actccgcaga ctgtgaagaa tttttccagc 4800 atttctgcta gttgctgtac taatcattgt aacattatga cctttcatat cttcaacgat 4860 aaattcgctt gtagatatta cggcattaat agaaccattc ctattactag cagaaagtag 4920 atatttcttt tcttcacctt cgcgaatgcg atatttctta ccaattttaa acataattac 4980 cctttaagta agtcgtaaaa accaccattc acatgcttag gagcggaaac taaccgaata 5040 gcaacccgat gacaatcagg acatacatca gtatcccttt cagaaatttt cttgattttt 5100 tcgtattctt ttgcacagtc tttggattga catttataat cataaagcgg cataattatt 5160 ccttaaagtg agctttcaac atctgataca aagaccatgc ctgtacatta ttttcaatag 5220 taacgttcat aaccgggaat tcagatggat cagttattgt tgcagattct tcctgctctt 5280 cagctgcctg gtatggattt tcaacttcat taaagaattc agcttcattc gatgaaagcc 5340 aaataaaatc ttcatccaaa atatctttac cagaagatag tactaaattt ccagcaaatg 5400 acataatttt aataggacgc ccaagagcat ccacatctaa aattttaaaa ggatgcatac 5460 ctaaacggcg tgcatagatt ccgttatcag tatggtcttt aataaaattt tcttgagctt 5520 gtttattttt aaattgatac catttattaa cttcaaattt aatagccatt aataaatttc 5580 cttccagtaa gttgtaccat cttcagtgat ttcacgaaat acaccgtaaa ttggttgttt 5640 atccccaacc ttttcataca cataaaccga agtcaagtga gtaaacttag cagtgtgttc 5700 cttttgaact actaccaaat ctggatcgaa taacacatct tcaaattcgt cattagtgca 5760 gctctgaaca attttacgtt tcattacaat ttcctcatta attgaacatt ggagcgatgc 5820 gtttcagaag agtagcagca cctttggcaa attttccatt ttattctcca agttattttc 5880 tgtatcagta gttgatattg atatagtacc ataatcaact actgatgtat acagttttat 5940 gaaaaaattt taaactttat gcatagagag ctttgctata gtgtttaatc cagctttcag 6000 gaatgacttt gtatgttcct aaaaatacca cattatacag cttaacaccg tcttctaccc 6060 actgatcggt aatgtatgcg cacatagcac gagtataaac agccaaacca tcatctttga 6120 taaatttaaa ttcacaagga gcaatgaact taatagcctg accgagtttc cacttaaagt 6180 ctacacctac atgcgaagta tcaatcgttt caattccttt agcaggaaca gctttcaaaa 6240 acgcagattc aagaaatttc gcacgaacat agccaaactg aggtttagac tttccatctt 6300 taggaatgat acgcactttt acttcagaat cttcatcttt aacgccgtgt ttaagctgaa 6360 tgcttacaat ttcgaccaat tttcctgctg ctttagaacg ggatttatca gatacacgag 6420 caatttcacc aatattaata atcatagtta tctctcactt gttaaaaaga ttttatactc 6480 cacaggacca ttatactctg gtcccaagag tttgtaaact attaattcaa aatagctacc 6540 actgcactac gaggtactac gctaaaatca cctgcatgaa caacgttcag aagttcaaca 6600 ccatcttcaa tccattggtc tgttacccaa ccacagaccg aaataaatgg agtcttgata 6660 gctactgcac gagtcaaaag gtcagtagga tcaacttctt tgaagaggat aagctctgct 6720 tcaaagacta tagttttaat tacttcatca ttatctaagc gatgtgctcg aatcacgtaa 6780 gctttattct tatcatacca attacttttt gaaaaacttt taaccacaaa ctcgccttca 6840 ccaaaaacac tagtcaatgc tttataaccc aaatctagtt cagtagtttt aatttcagtt 6900 tcaaccagtt tgtaggtttt gccaatttcg atggtccgag cagtcataaa ggtttcctta 6960 atttctaatg gtttaacaag agtgccgtac atgcttgcta tatccatatc aaatatttta 7020 tctataggat ttgggggtgt attcaggatt ataattaaat ttcataatta tctcatttca 7080 ataaaatcta caagttcagc atgggatttg cggaacatta cttggtgtcc gccaatgata 7140 acttcatctt caggaacttc ataaatcgca atgtacattc cacgatcttt taagtcttca 7200 cgctcttctc gggtgaacca tctcatcata tcatattcac tagcgaaagc aaaatggtat 7260 aatgcaataa accgcgatgg aatatacttt tcagacggtg aataattttt atcccattta 7320 gttttaatag cattattagc attttcaact aataacttat catcgtgtgg aataggaata 7380 ctttcatggc tttcataatt atcgctatga tgatgaaatg acgatgaatt aataccacaa 7440 aattttagcc aagttcgagt tttcatagaa tcaaatccac gataaggagt tgattgcacg 7500 cataactctt gcctaatttt cactatacca ctatcatcat ttaatgcgct aaacgatgat 7560 tcaacacgat aaattttcat tttattatcc tcagtagcta tggtgttata ataccacaac 7620 taaccgagga agtaaacaac tttttatcgt tttgttggaa gagatagagg atcgcactct 7680 tcctctgacg gagcatcttc aagacccata gcataccgca aagcatactt catcatcagg 7740 atgtctttcg cacagtcatg aatagaatca tgcgcaacga acccgtctaa agttcccttt 7800 ggaagaggac atgtggtcat atcacgaaca agcagaagtg cttcaattct ggtgcgaata 7860 tcgcgttgat tccagaattt acaaggttct aacttaaacg tatcaagctc attctcggaa 7920 acgccgttaa gacgttgaat atcgcgaatg agatcaacta aaattggaaa atcaaacgac 7980 attccacggc accagccctg agatttccaa ggatcgatat tatgcgcatt gatgtaatca 8040 ttaaattttg caataccatc gatagtgctt acatcttcat ctgatggcgc aatatttttt 8100 cgagcttcag gagattgatt tttccaccat tcgatagtgc ttttagtaaa aagacgatgt 8160 cctttttggc tttttaaatc aaatttgatt ttaatgccgc gtgaaactaa ttcatcaaat 8220 gtttcaacta cttctggatt agggtcaaag gcaataacag ccaaatcaat aacagctgcc 8280 ttttcaccgc ttcccattgt ttcaaaatct ataataaaat caaacattaa attttcctcg 8340 ctaaatcgcg aatttgacct acagtataat cttggatata aactttatta ataggctcat 8400 caataaattt tgccatagat tcaatatctt tttgtatctc ttcaagactg tatactatct 8460 ttaaagcttt ttcgcgaata gtaacattat caggtcctga attttcttgg atgacagctt 8520 taacatttgt cataagagat ttaaactgct gcaaacttaa ttcaatcatt aataaccgcc 8580 ttataaagat ggctaatttc acctaaaaca taatcactga ttgtaacagt tttcacttcg 8640 ccgcaaaaga attctaacgc aatcaaatct cgttcaattt cttccaattg aagcattaac 8700 ttgcctgatt caattttcac gtttttgcga tttttactat aagctatttc ataaatttcg 8760 ctcactttat cttgaagcag ataaaactgg tctttagtta tttccacgaa tagcttcctc 8820 aaatttaatc agcagcttac agacactttc atctaatgta attaccgtgt ctgtattact 8880 atgatatgat tgtttttcaa ttcgtttaat tgctagtata gtatcactta taagattaag 8940 cttataaagg agctcagctc ctgttatcat aacactgagg ttatcttgct tatcagtatg 9000 cttctttata ccatctatta gacgatttaa atattttgaa ttgatgttaa tcatatatcc 9060 tcacacataa aacacatcat aacgaccacg agtgacacca acataaagaa gctgctgagc 9120 tagttcagca tctgcataat gaatacaagg cgtatagatg aaagcacggt ctacagacat 9180 gccctgagct ttatggaatg ttgatgcagg aagtgctttc actttactaa actgtgattt 9240 agcatcccaa aaatcactcc acggagcttt tccaccttta ttccaatttt tatacgtttc 9300 tgccgtttta cctaaaaata agttaaactt atacagctct tcatcagatg aaattatttt 9360 aatcttttca cgataatatt catcatcgcc gtaagtttct actgttaaat cccaataacg 9420 aattagatat tctccagaaa caccacgagc tttaacaaat gttgatgtat actctgcttc 9480 tataatacga actaattgtc cgttattaaa aataatttct gacacaggct ttccatcaat 9540 tttatatgtt ttaattaatg gttcctgcat tacaataatt tcaccaacga taaaatcttt 9600 atcagtttca aaaatctttt tgcgaataat gctatttaac ttgtcgacag atttattcgt 9660 aaatgccatt acgcgatttt caaacaaatc atctagcgat tttacgattg aaaaataatt 9720 taccataaaa tcgcgtaaag cggtatcacc agtaaatcca cgtactccat gcccgtcaac 9780 aactttatca taaatccact taccgttgcg aacatcagta gctacatcaa taataggagc 9840 attactgcgt ttaacttcag tgagttcaca ctgataaaaa tctttatgcg taaagaatgg 9900 actgatataa gcagtgtttt ctcctgggtc aacaggtcta atttgcttat tatcgcctat 9960 tccaattata gtacaccacg gcgggatagt tgaaagcaga attttaaata gctttctatc 10020 atacattgac acttcgtcgc agattaatac tctgcattta gctaaatccg gtacttcttt 10080 ttgttcaaaa agaacgtttt cttcatatgt taccgggtta attttgagaa tactgtgaat 10140 agtactcgct tctttccctg acagtttaga aagaatcttt ttagctgcat gagtaggagc 10200 tgctaaaata atgccagttt cgcccgtaga tattaaggct tcaatgatga acttagtaag 10260 agtagtctta ccagtaccag caggtccatt aatagttaca tgatgtttct tttctttaat 10320 agccctcata acgatgttaa aggcattttt ctggccttcg gtcaaatcat caaatgtcat 10380 cgtaaattcc ctgcaattgg tatactaaca atacgcccag tatctaaaat tcgccgatat 10440 aatctttgtg tgtctacatc aggcttaaca tgtttaactt ctattttatt aaaccaaaac 10500 ttgcgtggag tctcaactaa tctcggaatt cccataccta aagctagtcg atactgatct 10560 ttaagagtgg taaatacttt atcagcaatc tccctttcaa aaaatacagc agggcggtgt 10620 tcatcaagag gaacaggcac tgcaaatcca tctttgtctc tatacactat cgcatataca 10680 taaaacatat tatcctcgga taagtttaaa aattgaacaa tttagcgggt atcctctttt 10740 cagtttaagt ttatcaataa aagacaagtt ttgataccgc tctacacctt gaataatttt 10800 atcacacata tcatattgca tttctgcttc tgacaacttt ttcacagttt tccaatcaga 10860 gcctttaaga agaacgttca atttaacaac ttcagcgcct tctgctatac gagaaccatc 10920 aatacgagct ttgagtgcta caatcgttag cttaatgtca gaggtttgtt ttgatttaga 10980 aagctgagaa atgtgttcaa ttcggttttc acgttttttc tgtatagctt taatttgatt 11040 ataagtcttt ttgattttag cccatttctt ttcatctaaa tttagtttat gaactttttt 11100 cgcagatgaa cgaccaattc gcaaagcaaa taaatcacgc ttttcaatca actcttctaa 11160 agtataatca gaacgaaatg tattatactt tttctttact gcaataacat tccctttaat 11220 gtatccaacg ttattatcaa aacgttctaa tgataatttc tctccttcaa tacgattatc 11280 aaaaggttct cctgagtaag cgcaaacttt ctggtctaaa atgttcttaa tgtaattgaa 11340 gtctaagtta aaatctttag aacgtctttt tgcagatgcc tgagtatgct ctaaacgacg 11400 tttaatttta cgaatttgat tattagacag tttcatattt ttctcacatc ttacggacga 11460 ttgactacta tactataaca tttttacctt ggcttgtaaa caactttatg caaaaatgct 11520 ttaaaacttt cgtggtataa tgaatctaag tccttccatt atagattaaa tccttcaaaa 11580 tcaagagtat agatagtgta tgttgaatac tttttatact catatctatc tgcaattcta 11640 aatacacttc cagctggtat cattacttcc tgttcatctg aaactaattc catattacga 11700 taacgatggc tatctggaaa cttaaaactc ggactatatt ctttacaacg tagagctttt 11760 atagcatact cctggaaatt aaacaccata ggagctttga attcaaaaat aacttgtgtg 11820 ttgtattcta atccagaagc aaagtgtaga gctatatttt tatcatatga agctgatact 11880 actttatcaa atgtaataat atcaattcct tgatttaaca cctgtttagt ctcaactgga 11940 acacctctcc aaagaggttt atcgtttgga accaaacgag atttgattat ttcatttaac 12000 caagaatgat cgtctggctt attagtaata caatgaatta aaagttcaat ttcggataaa 12060 ttaaatcctt cagaaagtaa ttcttcacga atagaagcac gcaccgatgc atccattgat 12120 ttgattttaa aatcttttaa ttgcattgct gaatatttca ttcaactacc tcaacatcat 12180 acactttaaa tgttccaaat gaatcgtgta atttttcttt tgaaatagaa gttattttat 12240 actttccaat tggaatcatc cattcttgtt cacgtacaat catcattaag ttatcagtac 12300 gttctgaatc taatccatca gtatcttcat atgtatactt aaactcagta ttaggagaag 12360 aaagtataat atcgctgata tggtcagaat aattaaaagc tttatcagtt tttaagcgaa 12420 atattatttc agtggaatat tcaacataag aaaaagaaca cgctgtgtgc aaactagtag 12480 taaatgaatc tactctgctc gttgaaaaca cttctccgac ttgtaaatct ttaatgagtt 12540 cttttgtcga ttttgatata ccacgatata gctgataagg cgatttagtt aaatgctttt 12600 taacgatttt attcaactgc tgatgaagag cttcattctt tttggcttcc atacattgcc 12660 aaagaattga ctgttcaaag tcagtaaatt tttcacagac ctttttatac atatcatatt 12720 gaaaatcgac actttcagct tttatagata actgttcaac atctgcaaga ttaataatca 12780 tgatagcctc cgtatacttc agaagctatc atatcattgt taggaaggaa agtaaacaac 12840 ttttttgaat tattttgccc agggagccca gggcggaggg tcaagatggt atgaagctag 12900 ttcttctaga agagcatctg gggcttcaat tccataattc tgtaatacta tacggtactc 12960 tttcttataa tcactagaat cattctggat attcgtagaa tgattatctt ctaacatctc 13020 aaataaatcc atattaattc ctagcgataa aaaccaaaat gacgattagc ttcaataatc 13080 tttctttctt cttcggacat tctccagcgt agtccaacat caaaatgagc ccagaccatc 13140 ttaacaaatg catttatatc tttaatatct tcaataatga atgttttact tttataaggt 13200 tgactagcta atttaacttt atcgtcttca aacaggtcaa aaagaccata ttcatgagct 13260 cttttatagc ctttaatagt taaagcttca gaagaagaaa acggtgaatc agtattccgt 13320 aaaatatctt cagtatgctt tataattaga ataacatttt ctggatattt tctttctttt 13380 atatctttaa ttaaaagatc cggattttct gctaaaggaa taattaatga acacttttta 13440 tcaagtgtat ttactgattt accttcttta gacataaatt ctattgaata acgttttgct 13500 acttcaatca tgtgatttcc ttttgcctac taatggaccg tcaggaattt tgttttcctg 13560 aatgtatttc tcattttctt ccatcatttt actgccaatt ttaagaagca aatccattgc 13620 ttcatttgct ttagctttag cctcttctaa cgtcatatct ttgttcatga tttatcccca 13680 tagatgtctc tcatcaattt aagcgctgag cgttctaatt tcttttcttt ctcagcacta 13740 atcattgatt tcatccattc ttctgattcg ttctgcattt ctttatttac ttgttcaacc 13800 caaccatcat caatatacat tgagtttggt ctattgaacc attcaagcat cttcttcaga 13860 actttcattt gttttaccta aaacaatagt aggagcatcg tcaaatttat gaatttttag 13920 taaatttgga tttaaattat tccataaaga ggtaataaaa tatgatagcg cattttcttc 13980 tgtaattata aatttatttc ccttatctat tttccagtca tatattgaat catatgaata 14040 taatggcaat ggtttattgt tataatatga ttcagcaaca tcaatatagt tagatttagt 14100 aaatgcttga attgacataa atggagaatt tcgtacagtt tcaataattc cgatcttttt 14160 aagttttatt tcaacatctt ctggaactgg cattgaaata aaatcttcta ctagatacat 14220 gttattatca tatcttttat caatcattac tgctacggta attggaacgt ctttagcaaa 14280 cgacaaacta ttactgctaa tatacatttc aaacaaaatc gcttccataa ttttcctcaa 14340 tcacaagatg tagatgaaca actagaatca caagaacttc cacatgaatc gcccgtccat 14400 acatgaacag gaacattagt gtcatatgaa tcagaactag actgtgtatt ctgcgtatta 14460 gatgatgtag gtgttgacca acgccaagga tttttataat attcctgggc ttcttcataa 14520 gtcatagtaa ctgcttctac tgttccatct cccatataaa catattcaac tacagttaaa 14580 ggaaggtagt catttgaaat aggaactaca ccttctcccg gagtcgtaga gaaaaaatcc 14640 gtaaagaaac ttttaaacca attaaagata aacattacaa aaagcctctt tgaaattcga 14700 ctctttgaaa tccaccccag tcagtatatc gcatttcagc attgaactcg actgaaccat 14760 ctgcatgcat catgaatgaa tgcgtgacga tatcacaatc ccagcttttc ataccccatt 14820 tatcagagat agctttatca agaaccttct ggaggtcttc atttggttta atccaacgat 14880 ttaacatagt gctctcctct ataagataat tctattatac catactcatt gtggaaagta 14940 aaccggtaaa atgaaaaaag gactcccgaa ggagtccctg aattattaac caccagttac 15000 tttccacaaa tcttcgtttg cagtaatcca tgcatcacgt tgattttctt cgtatacagt 15060 agtatatgct gctttttctg aagggaatgt ctggtaatga gcgccagaaa ttttgtgaac 15120 gtcagaataa agagggaaag ctacagaaat ttcctttcct tcaattttct tatttccgtc 15180 taatttctgc tcaaatgttt taatattaac ataaccgcga gtactagcca tgtaattctc 15240 cttttattta aattacatga ctatttataa taaattctca cagcttttaa gccgtcgttt 15300 atattaataa cctcggtctt gacgagcgaa gttttcagca tttttcagat aataaagttt 15360 aaagatttct tcagccgtaa gaccgagacc ttggaacatg ttcagaacga aatgaagaat 15420 atcaatcatt tcgaatttaa tttccaactg gtcttgtgga gataaatcag taatcagagt 15480 ttcacgacgt tcaccgtgtt gcgacttcca aggcttccat acagcagacg catctttttc 15540 gccattgctc ataccaccaa gagaagtcag aagttcgcgg aattcatcat caatataatc 15600 tttctgatta cgcagccaat caacaacttc acctgcagta gccaaatcat caggatgacg 15660 gttatattca ggtttatctt tagctaaacg aacttgcaga gatttctgca tatcaagcat 15720 aacctgcagc gggtcttttt catcaccgag aatatcccag tattcatttt gagctttatc 15780 agcgccttca atcagttgac tacattcgtt aaagtatgcc attatttttc ctttcaattc 15840 atgggttagt agattaatta tacaataaat atataaagca ataaggagga tatatggtac 15900 aaaaattaat ggcacttgtt aatgccataa aaggtaataa aaaacgtata gcttttacta 15960 tttctgctat ggtaggaatt ttactctgga attttgtttt atcaccaatt gctattgctc 16020 atggtgttaa tattccagta attactcttg atacattcgt agatttagca tttgctttag 16080 ttgggttaat ttaaatctta gcatatttag atagccgcat tttagccatc aacccttgag 16140 caatattatt tttcatatat tccataattt gttcaggggt tgcaccttcc tttctaatca 16200 tatcattaac atcttttgat ttccagggag atttgtccca aaacataacc ctttctcctg 16260 catcaactaa tttagtcatt cgtttaatag tgtcagggtg acgaggttca ttatctaaaa 16320 cccatacacg tctatcttta aatggaacaa tttctaggtc taattgacca cccgtaatag 16380 ctataccatt ttcaataaaa agtgaatcta taggtccttc tagaacatat acatcaccat 16440 ctttgactcg ttcaactcca tagatttttg ttgcctcagg ataagctttg atggtgatat 16500 atttttgagg agcatctttc tttaatgcac gtccttgaaa agactcggct tttccgttag 16560 cattataaat tggaataaca agacgaggct cgggcatttc ctttttatat gttcctggcg 16620 ctatactatt aactaattta ggccattcgg ttgtaaacca aagatatttc catttatcct 16680 ttggaataca acgagctttt acatatttta taattggatg gtcttccgcc agtttatcta 16740 gtctaatgca tgacggaaga gatttaatta ttttcttctc aggttgttta gaaagttctt 16800 taggtttttc tactggacga cttttacctt tttcttttct tatttcaaag atatactcac 16860 gatataaatc aggttcaaac tcctttaaat atattccgat tggtgcatga tagttacagt 16920 tataacaatg aatatttcct tcattattat cgccataata ccatccacgg gctttatttt 16980 gatcggtttt tgaatctcca caaacaggac atctaaaccg taatttaaaa gttgaactat 17040 tatttacttg tgcgaattta ggtaaatgag ctaatgcacg gtatgcaaac tcattatcaa 17100 tccaaggtat tgatgacatt tttactcttc tttttcttta gattcctctt ttttcttttt 17160 aggaatctgt tcaggacctt tatttactac agcgcctgac gttgttccag tggagatatt 17220 ttcaggatta ccacctgaat ctccagctac catatcttct ttgataaatt ctttatatgt 17280 tttcatatta acctctattc ataaaagcat taaaaatttg gtcatcaata gaaacattta 17340 ctttagactg tttttctgat ggtaattcat atccacatat tacaattttg tgatcaatat 17400 caaaatacac agaagcaata tgattaatga tgttttcagt aaagtctaaa tcaacatcaa 17460 tatctttttg accacagccc aaaggataaa taatgcgagt aattcgatta tctttaacaa 17520 agattccacc gatatactct gtgctgcgtt taaagtctac acgccgacga aatgaaaaat 17580 attcaggctc tttatgagct ctgctcatag gacacaacga gtaactagaa taagagatgt 17640 caaatcctac gccttcgata tgagccaaag tgtcatgatt aaaccaatta taatcgtacg 17700 ccaaatccat tagattataa tatgtaaagg gcaccggatt aacatcatta gtcacaagca 17760 tgtaattagc aactgctata atttcattgt ttttaacgaa tacaaaccgt gattgatgtg 17820 aatgacctgg acccgcgttt tcacgattaa tgatataaca ctgggcacct ttatatttgt 17880 atgtatcttt gcacttgtgc atttgataga gcattattca cctaccactt cagcgatgat 17940 atttttatta ttaaagtttt tatcgcaata cagaacataa ttatactgca ttacaccacc 18000 agacttaagc tgtttttgca cttcagcttt catttcagga cggtcacgct caacgatatt 18060 cataatatct gcttcaattt gagtttcaac ttcagtctga tctgcagtca tagaccactc 18120 gcacaaatct ttgtcataac ccgccatagc aggctgagca gcgcaagaag ataaagcaaa 18180 aattgcagca aagataaatt ttttcatgat aatctcctca gtagtttatg tttatatagt 18240 atctcaattt ccaataaaag taaacagtta ttttaaaact tctgcataat cacatgttac 18300 aaactgtttc tctaacttgg cgattttacg aaagtatctt ttgcattgac gaatctgtcg 18360 cttcgtaggg cgcacagcaa acttaataaa ttccactcga ccaaatggag gactttcttc 18420 tgctggaata tctaatacta attcccacgt atctgcaata agtgctttga attgagtatt 18480 tttcctaaca ttatacggag taggtttaaa taaaacgata tgcatattat cctcggcaat 18540 ccacttcgca tactttcttg tcatcaatga aagctttaac tagtgcttta ttaacttcag 18600 catattgatt agtagcccag tgaacgtcat ctttcatcat tgtgatttct ttagtaaaca 18660 tgctttcatt cttaaaccac cccataaaaa ctacctttac caattccata acaatctcct 18720 catttaacca acaagactac tataccatag tcttgtcagc ttgtaaacta aaattttaat 18780 tcatttgcca aagcatctaa ctgagctcga gcggattcgt ttctttgata gcgattctgt 18840 tcagcttgaa tctgctgtga acctgctact tcgttcactt cagttggagt agaatcttgt 18900 tcaatttcta cccatttctg atttcctttt tgaacaccca tcaaaaactt attccattta 18960 ttcttatcac cgtatcgtga tttgatttgc ttaatgagtt gttgttcagc agctgctagc 19020 tcctcggttt caatgaccgc aagcataaaa tcggctgttg ctggaagacc ggcagattcc 19080 gcaatatcgc tcatgttaac atcagaagaa tcccaagctt gcttaccaac ctgtgctgca 19140 gtccaaagaa cggtttcggt ttcaacagcc agagcacgca attcctctgc gatagcttta 19200 acagttgtgt aactattttc tgaataaact ctgatgcggc aagatttaca aatacctaga 19260 tagtcaacaa taatgattgt tggaacaaaa ttcttcttga gctttaattc atttaaaagc 19320 gaccgaaatg tattagcgtc tgctccacca gtaggatact gtttaacgat taaacgaccg 19380 agagtagatt tctcacgcca tttttccatc tttcctttat actcagcgta agaaatatgc 19440 ccatcatcaa tgtcatcaag agaaacatca agcatattag cgtcaatacg cttagcacaa 19500 acttcttctg ccatttccat ggaaatgtaa agaacattat gtccgagctg caaataatct 19560 gctgccaatg aacacagacc taatgactta ccgacgttaa caccagccat taaaacgttc 19620 agtgttccag tttcagctcc acctttagta attttgttta gaattctgag tttaaatgga 19680 actttacgag ctttattcat ataagatagc cagcgtgctt cgtagtcatc catccaatca 19740 tgaccaacgt agctatcaaa tgaaattgat aatgcttggc gcatgatgtc aggaatagca 19800 ccaacgtccg gcattttctt atttcgtttt tccggaggaa gctcagcatt agtttgaatt 19860 tcgattattt tagacgtagc attaaacatc gccctttgct gaacatattt ttctgtttct 19920 tttattaacc aactgtggtc ttctggagaa tcggctagtt tcgaaataag tgtttttta 19980 ccagaatatt ctgtttcagt aaatgaacta ttttctaatg caacatttaa cgcattaata 20040 gatggaacgc tatggtactc attaacatga gatttaatta atttgaatgt atttttagct 20100 ggaccacttt caaaatattc tgaatccata tatggccaaa cttttgaaaa ataagcttga 20160 tcaaatatga gatgagaaag aataatttct accacactta ctccttaaaa gaatttaaat 20220 tttttctttg accttttatt aaatgcatct tgtagttgca ttgtaataca tttttctaca 20280 tgaggagcta actcagcttt tctttcttgg tcaagaacag caaagtccat tacgactttt 20340 ccatcaaccc aatctaattt tgtcacatac acaatgtgtg tagaaccgtc ttctagttta 20400 atgacaatct cctggataac attttccatg gcagatttaa ttatcttaag agattcatta 20460 aaaagacgtt cttttctttc ttcttccccc tccgaagagg gggattcatc gataatttct 20520 agatctaaat ctaaatcatc tttattcatt aaattcttcc atatcactta actgatctag 20580 gtcagtttct aaatcagctg ctgatttact tttactttct ggagatttaa atttttcaac 20640 ctttgagtta atcaattcat caacttcagc ttcaacaatt tcattactat caatagcacc 20700 taactgataa gcacgtttaa tagcatctcg gaatggttga tgcttaaata aaggacccca 20760 gaatgtagtg caattggtat cttttgcacg ccaagatttt tcttcgcgaa tcatctcgcc 20820 ggtttcttcg tcaagaaatt cacgagcata ccagccattt ttaggtttta ccacaaatcc 20880 taattcaaga gccatatcta acaatccaga ataaggatcg ataccaccgt caaatttaac 20940 atcaataaag aatttacttt tttctttaac ggtacgagat ttttctacat ttagaacaaa 21000 ttgatacccc tgaagatcag aaccatcttt aatctggcgc ttaccgataa tgaatacagt 21060 atcagccgaa tacattacgc ctgtaccacc tgtcatcacg gttttactaa acatttcaat 21120 tgtttcaatt gtatggttaa ccgcaacaca tggaatgttt ttaatactaa aataaggagt 21180 aacaatacgg aataatgact tcagtgattt agcacgagtc atatctgcca cagatttttc 21240 attcaaggca tcttccgttt ctttcttaga agccatatta ccaattgagt cgatgaatac 21300 aataactttt tcaccacgct caatagcttc aagctgattc accatatcaa ttttcagctg 21360 ttcaactgac tggattggtg tatgaattac tcgttccggg tcaactccca tggatcgcaa 21420 ataagctgga gtaataccaa attcgctatc atagaataga cataccgcgt caggatattt 21480 gttcaaatac gccgcaacca tagtcaaaga catatttgat ttaaagtgtt tagaaggacc 21540 tgcaaaaatg gttaaaccag actgcatacc accgtcaatc gcaccagaaa tagcgatatt 21600 aagcattggg atttttgtac ggattacatc cttttcatta aagaatttag atgtagtcag 21660 ttcagcagtc attttagaag tggaagcttt aatcaaacgg gattttaaat ctgcaataga 21720 cattcatttt ttccataggc aacattatat tttcctcact ggttaaagat agaataatta 21780 taacacaata aatttaggca ttaatcaact gctattggat gaatagcatt aaacttatga 21840 aacgcttctg atttttcttt gcgcgaaaca cacatgcgaa gaacttttaa tggctcgtct 21900 tcttcaccca acgattttct cttttcgata ttcgatgttt tccaacgagc ttgctctgga 21960 aactctctat tgatttgctc aagagctcta ttatgttttg aattactacg aattgaacta 22020 catccgcctg gagcttgtgc ttttccagat acaaccagat atttgaacaa ggccaaatgc 22080 ggataacctt gattaattaa attgagaaat gcatacatat cttcgcataa atcaattttt 22140 ccatacccaa tttgttctgt cgtaagtttt ccaaggtcat accatgtatt cgtgaatcca 22200 tatgaatttt cacgataatt accccaagat gaagtaattt taaaaattgg tagacgagca 22260 tggccatgat aatatccgca atccatggca tcctcaacat attgaatcaa ttcatagaac 22320 tgttcacgag ttaattgatt aattttatct acacagcgac gatcatcttt ctttcgcatt 22380 gaactcatac gaatagtagt atcatcgtca atcatccaaa ttcgttgacc tgcatacata 22440 tcagtaattg ctttacgagt accagcaatt ccattgacat catcaggaat agttataatt 22500 ttagctctag acccataagc gtcataataa gctttttctt cgtgtttacg tactacaata 22560 tgaggttcat aatcagatgg aaacatatca agggcagaaa ctgccccgac acgctgataa 22620 cttggaatta cgaattgaat catttaagtg ccttacattt gtcaaaatgg tatcttgtca 22680 ttttggccc acgtcctttt agtccgcaat gcggacatat tttttctatc aaattatgag 22740 gttttccttt acgattttta gacatcgttt ctttaattat tttagctttt tctacgccaa 22800 aaatttcttc ataagtttta ccagaatttt ccttggctcg atttataatt ccatatgcct 22860 gctcattttt accatacatt ggattacctt cgcctttcat tcttttagaa tgatcaggac 22920 gcttgattcc acgaaaggca tttccgcact tatatctttc ttctggagat agttttttac 22980 cgtacattcc atttaatttg cctggaaaac ttcctcccca tgcttcattc tttaaattat 23040 atgaatccgg acaattagca gcatctaaac aagttaaaat aatttcttca acctgtctaa 23100 acattggtcc ttcatataat atttctttat taaaggattt tattccatat ttctttttag 23160 catgttgcca aactacaccc gaaccatcat aattcgggtt gtgaccatca tgacttccta 23220 tataccactt tttagtttta ggatgtttat acttataaac atgtggcaca tttacttcca 23280 ttttccagta taatcctttt tagcaatatg agtctcaccg gtgttccacc aatggtcaac 23340 taaataaaac tgattttcgt acacatgaag acttccaacg ttccatataa tagaacctgc 23400 tttatattgc cgcgatgggt cgcctgcatt caaatcagat actaatttat ctagtacgta 23460 tttttgccaa gcataatcat tacgatagcc tgcccagcaa tcattgcttc tcatgctaac 23520 aaccgcattg actttcttat cacgaatcag gtactgtact gtattagtac acatgaaatc 23580 tgacatacca tctttattgt agtcaaattg catggatgga cgagtataaa tcatgatacc 23640 acgtcgagaa tcaggatttt gaccaagttc agctaaacac atatcatact gggcatagtt 23700 attttctgac caaatagccc aaccataatt cgagttaatt tcgcctttag aagatgctac 23760 ctgctgccaa atctttggtg tttcacctgg aatatcttta acaaacaagc tcttagattt 23820 ataccattca agttcgcgct gaatgtattc atcattaaga gcgccaaaaa taaacggttc 23880 atctgctata aatgatgcgc caataatttc aatagtttta acgccagttt tatcaactac 23940 gaaatctttt tcttttaatg caagccccaa atgaagacgg atttcttcaa ctgtcataga 24000 gtcactaatc atttaaacct caattgatac attcatattt aacttgtaac agtaataaac 24060 cccaccctat gataagagtt ggaatcatag caggaactgt tacgctatag tatatactta 24120 ttataaccat caagattaaa agcaacactg ctataatttt gcttttcatt ccttctctct 24180 gatgataatt acctgatttg gttgtgcaga ctttttagtt tcacccacaa ttgaccaaat 24240 aaatgtaata aaccaaccaa taattgacca gttaaacagt aaagatgtga aaaagattcc 24300 tactgtcgat tttgacccac gcatcaaggc gataaaccat ggaagcatgt atataataat 24360 agccaacaca cctgaaacta aaaccataaa aattgaacct gctactaaag tttccatgtt 24420 ttcctcactt agtcaaattt tttacacatg aattataaga attcactaca tactccatcg 24480 gagcattttt accagtacgc cattggtaat tattagccca attagcccaa atttcggcgc 24540 agtaattttc aattttttct tcgcgtgtaa ttacatccga attacgatat gcttgagcag 24600 attcatctgg acgaatagct tcgtcaaaat tcgcctgcat ttgttcgact gtttgctttg 24660 gagcttcttt ataacacttg acattaggat tataaaattt gcttgaacag tttacaattt 24720 ttcctacatc agactgattt actaccggtc cttgagctac acaaccagta agacctaatg 24780 caataaccaa aatagcgatt ttcataataa tttcctcaaa tgcaagtagt aattactcca 24840 gtagtgctta tgcaggtatt acccatttgc acacctaaag atccatttgt attcacatga 24900 agattatcat caattttaac tgatatttta ccattagtgt gaataacggt gctagattta 24960 atcacaggtt gagtatcatt ttcaacacta acaaatggaa ctgctactaa tgcaactaaa 25020 caaactgcta aacatcccat aacaattttc attttattct ccaaatctgt atcagtagtt 25080 gatagttgta tagtaccaca gaagaacagt cttgtaaaca gttttgtgaa aattttttag 25140 ggaattctaa aggtccagaa tcatctgttt ttcataagta tagatttata ttacttgtat 25200 gaaaaaggga cccggaggtc cctagattta ttctatcagc caaacaggaa gtctaacgaa 25260 gctttttctt catagtccat accagccgat tcacacatgc ctgcaagcgg tttaacaaac 25320 gatttttgga acaaagttga gtagtcaatc caagacagta catcagaacg aatttctttt 25380 ggaagttctg tacccgacgg ccaagcaatg cacttgtcac caaatggatt tccctcacgt 25440 aatggaagaa ccattacttt atttccatcc aaaattggag ctacacccag accactaaca 25500 gctcgacgat aagttagcac cccacgaata tggaacgggc atttaaatcc tggccaacct 25560 ttatcatcat atttcgctat atcgttcgca gtttttactt cagcaataac tttatagtca 25620 agttgacgat attctttctc aaagttctta taatattctt gaacagactc ttcgccttct 25680 tgaagaatac gcggatact ttcttcaaga gcttcttgga ccgctttagg cgttgaactc 25740 tgctgagttt ccatacccat gatttttaga tgcggttcag caaatcgctt atcttccata 25800 tcataaacgt tcagagcata acgctttttc gctttccaaa atccaccaac gccctttgaa 25860 ccaagtggag ggcaagaaat agcttcacgg tccatatgca tcagatgctc gcggttattc 25920 atataatcac ataactcacg atatgcaaca tcaatcatag gttccatctt tttcttaccg 25980 aactgattca tgaattcaac taaatcgttc tgctctttga atcggtcaag accaactttt 26040 tcaataactt tatctacaca aacatatacc gaatcagtat cacctgctgc gatgaaatct 26100 tcgccattag ttccacatac tttattcaga tactcattaa ttttacgagc aatccactga 26160 ataccgactt ggccgaaaat tgtgatagca gtagcatttc gcaaatcata gtagcggaaa 26220 tgaatattac caagagcacc gtaaaggctg ttaataagaa ttttacggtt cagctgattt 26280 gtattagcaa gtgtagccgc tttttcacat tcttcaatca aactattgag aacagattca 26340 gtataattcg atagttcatt taagaaatca tcactgaact taacatatcg tttaacttca 26400 ggtttagttg aacaagaccc tgcgcctttc ataataatct ttttaatagc ttcggcattc 26460 atttcttcgg cgaacatttt ctttttccag tctttacgct ggaaaaatac tttagcgatt 26520 tcctttggaa tgataccttc ttgatgctta tcatacatcc atccattcgg agaacaagaa 26580 tattcatcac tcggtttagg agctgttcct gcgatatatt catgaattgg atgaacttta 26640 aactgaccac gaatagtctc aggactaatg ttaacctgac gaataatgct aggatacaga 26700 gacgtcaagt caaaactcat aatatatcga cgagcaattg gtttaggttc aaacacaaat 26760 gcacccggaa aactttgttt aacgtgcgaa ccttgttgag gaataacctt atgttcacct 26820 ttcaatgagt taaaaataat agcatcccaa gttttaatag gactcattac accagaaaaa 26880 ggcattttag cgtaataaga catacttaaa actagatcga taaacccgcg aattttatca 26940 attgcttgaa ctgattctac gtcaatgatg ttataactga tatatcgttg atgattagtc 27000 tcacgaagtt tattaatagg accatcgtac ggtaatttac cttttttggt ttcatgctga 27060 gcaactgatt ccaaagagaa tgacggcaaa ttagtaaatg cgaatttctt atacaaatct 27120 aaataatcaa gaatagatac gccatcaata gaataaattt ctttgctacc gtacatattt 27180 tgaattagtt tagattttac tcgaccgatt ggagagaaac gtttcatact gcgttcaccg 27240 agaaccattt taacgcgatt catgatatac ggaacgtcaa atccctcaat attccaacca 27300 gtaaaaatag caggtcgttt ctgttcccaa agattgatat attccatgag catatcgcgc 27360 tcattatcga atggcatata aattactcgg tcaagaattt cttgaggaac ttcatcacca 27420 ccttcacagt caagcttagc agctaacttt gcgtcccatt ttgatactga accatacatt 27480 gaattcaaaa ggtcgaaaac ataaaaacga tcatcaattg aatcgtaatg agtgatagca 27540 tcaatttcat attcagcttt cattgggtca ggaaatttat caccagtaac ctcaatgtca 27600 cagttagcta cacgaacaaa ttttcggtca taaacaattt ctgaaccgta tgtatcactg 27660 atataagcga gtttaaaatc gttcataccg agagcttcga gaccgatgtc ttccattcgt 27720 ttcatccaat ctcgagcatc tttcattgat ggaaattttt gaggagcgca gtttttacca 27780 tagatgtctt tgtactttga ctcttcctta caatgtctaa acatagttgg aagatattct 27840 acttcacgag tacgttcctt tccgttttca tcaatataac gttcaacaat gttatttccg 27900 actgtttcga tagagatata aaattctttc atagatattc cttagtttat agcccgagtt 27960 attaggctct tgatatatta tactccaatt aagggggccg aagccccttg cttaattacc 28020 aatcgtatat ttaggaacga gtttccattc atgtttttgt ttaaaagaaa taactcggaa 28080 gttattagtt aaatctttca taaaagttct ttgaccagga acgatttcaa tcagtcccca 28140 atcttctaac agccatgcaa tcgaatcacg acgaacttca tcttcttctg tcatttcaac 28200 ttgacgacca tccatacgaa gcatttcttt aaaatgaacg atatagtata gtcctttttt 28260 ctgaagaata tgacaggact gatacagaac tttatcttta ttattagcaa ttcccatacg 28320 agtcaaagtt tcttttactt tcagaaaatc ttcaggtttt ttaagagtaa tttcaatcat 28380 tttaccattc caatgctagt tttttgagtt gtttctgttc ttttacgttc ttagtcactt 28440 ctttcaaaaa atcatccgtg actaaacctt ttagttcttt taatactaaa ggaagttttc 28500 catttttagt aagaattgat ttatagttaa ttgcatcatt tgtattaact tgataccgct 28560 tagcaagtaa cttaataatc aatacttcgg tagaatcttc gaccagtttt gcccatttac 28620 catatctttt accccgagga acagcagcca tcagataatt aaaatgggct tcatcgctta 28680 aacctgatcc aattaaattc atcgcatata cagctggcat gcattcagga aattgtgata 28740 atgcattctc aaccatgtat tttgaataat ctttttgagc aatagagcat ttagttttat 28800 tattaatagc tccaattatt tcaaaaaatt cattttcagc tttttcctta aaagaatcag 28860 cagcagattg gacagctgtc caatcttttg aataccaagc aacttgatgc tcgtttaatt 28920 gaatatcatc ttcaaataag ctcatatcac ttccactgca tttcgcatgc taattgaatg 28980 aaaagatatg ctaaatgtaa ttccgtatta gccgcaattc cgtgatactg gttattttca 29040 ccaacaattt catacatacg aataatactt tgtggagtta cgcgtgtata gatttcttcg 29100 gcaagtttac ctacgaacca cgaataatca gctgcatatt ttggtgctaa agctctgagc 29160 tgtttaacat ctttattttt gagagactca agaacatcat caatagcacc acgatcgtta 29220 gtaaccagtg ataaaatacc agcatccaaa acacctttag atgaataact atcgagctca 29280 ccaatagttt tacgaaaatc aggaaaattc tttttaacta aagctgctac aactttcata 29340 tcagctatag caattccttc atgcttacag atttcagtca atcgacgaat catctgcttc 29400 atcatttcaa ttttatcttc atcggtcggt tgaccgaacg taataactcg gcagcgtgac 29460 tgaagcggtt taataatacc atcaatattg ttagcagtaa taataatact acagtttgaa 29520 ctataagctt ccataaagga acgaagatgt cgctgagact ctgctaatcc tgaacggtca 29580 aattcatcaa taacgattac tttttgacga ccatcaaatg aagctgcgct ggcaaaatta 29640 gtcaaaggac cgcgaacgaa atcaatttta caatctgacc cattcacaaa catcatatca 29700 gcatttacat catgacacaa tgcttttgct acagttgttt tacctgttcc tggagaagga 29760 gaatgaagaa taatatgtgg aatcttacct ttacttgtaa tagatttaaa ggtttcttta 29820 tcaaaggcgg gaagaataca ttcatcgata gtagatggac gatatttctg ttcaagaatg 29880 tgttcttttt catttacggt aatcataatt tcctcattca agttttagtg taaattataa 29940 agggccgaag ccctctatta aaaatcgtgg gtagaatcag cttcaagagc tactacataa 30000 ttcgcgtgtt caccttcaaa tttagcagca ccttgtttac cttttgccca gagcagaagt 30060 ttataatttc ctggttgcat tttcatattt gccatattga taatgaaatt aaatgtattt 30120 tcaccatcat aatcaccaag agtcaaagaa tatttaacac gggtcaaagc agaatcttct 30180 actttattaa aaccgttaat tacgatttta ccttctttta ctgtgatagc aattgtatca 30240 atctgcagac cacgagatac acgcaacagt tgttgaaggt cttcagcttt aatttcagta 30300 acaacagatg ctaccgggaa tggaattggt ttattaggag caactactgt actcggatcg 30360 gctgctggcc aaaaaattgt tgaacgggca tcagcaattt taatatttcc atcttctgac 30420 tgggaaattt ctgcatcatc attaactaga gacagaatac cgagaaaacc gttcaaatcg 30480 taaattgcta catcaaaatc aataacgtca gaaatatttg cttccgcata agttgtacca 30540 ttaactgcgc gagtcataat aaattgacct gatttaagca taatgccaga gttaatagta 30600 gcgaaatttt tcaaaatatt cagtgtgtct ttagataatt tcatttcaat ttcctattta 30660 cataatagtt agaccaggac cgtacagcac cctgataaga ttcgtcgtta aacccattag 30720 ctactgcaat tttacgaaat ttattataac ttggttttcc gtaagcatgc cataaagatt 30780 ttaattcatc ttcatgttca atccaagttc ctctagcttt agattttcta aattttgatt 30840 tgaattccgg taaattattt ctaacagttg cttgaattga agctctctgt cttctttcag 30900 cattattcca taattctttt tgagatttag aaatttttga tcttacactt tctgaattca 30960 ttatatcact aaacttttta gcataactac aatcaagata tttcaatttc atcttatttg 31020 agagtttaag ctttttctca tcggtccagt gattcttcat tgaattagat attttgtatt 31080 ttacttcaga actatgtttg taacctttac gaataccgac atactcaggc gtaatttcag 31140 attgcgaaag ctttacaatt tttccagtta aaacattttt atatgttcca tatcctttag 31200 caccaattaa agtattttca tctgcgtatg ctttattaaa atattttata ttactttttg 31260 ctttaacttt taattgaaaa aatctctcca attttcttgg atctaatata gtttcagcta 31320 aaattttgac ggtatattta gtggttttaa taagttcaaa atattcatcg ctataactcg 31380 atgacacgct tccagtataa atctttccag ctgaatcaat tatatttgtt ccatcgaaaa 31440 ttgcgttaat ttttgaacct atataataac acgggaaaaa tatttttagc ttcccgctct 31500 ggaaagctaa taagatatac taaattcatt tattaaactc ggccacaatt gtttccgcaa 31560 caatttgtgc agcaacaatc agacgttcat ctgcattacc gcaataatca tcttcaaggc 31620 gttcaccaca tgaagtcata ataaatttag caccggcgtt tagggattct gcagtatgtt 31680 tgcgcattag ttcaatccat ttattactta cttcacgatc gatagcttca taatacgcat 31740 gacgagcagg tgcagattta attttgttct gaataacttc cattgcgtta tcagaaagag 31800 acaaaaccca tgcgcgacga attttatttt ggttttgcgg atttgagtca gaacgcacgt 31860 gtttggctg aatatctttt acatcaacag tataattcac agtaatttta gtcataatac 31920 acctttagtc ataataatca gtaacagtcc aagcttcatt tctattggac attatttttg 31980 tatattctgc tttaaatgca ttcctaagca tagattcagt aactatatgc tcttcattag 32040 aaaaattatt tctcagaata tatcgtttta tttcaggaaa agttaataga tgctgtccag 32100 ttgaatattc catgtttttc ctccatagag attatactct aataaattaa agcataatct 32160 cttataaatt aaaccattac agtaaatcga ccaactttct tcatttgaag atgctgaccg 32220 tattcttgcg ggtcatggtc tttatgcgaa attataaaaa cattagtgtt tttcattgaa 32280 tttataatat tagctacacc tttaatacct tcggcatcaa atgacccatc aaacacttca 32340 tcgagtatta atgtactaat actaacacca gatacaatag aagcaatatc acgccaagta 32400 aataaaagag caatatcaat tcttgctttt tcaccttcac taaatgaagc ataactaaaa 32460 tcttcgcgac cacgggattt aattgtctca ttaaattctt catctaatgt aaacacataa 32520 tccgcttcca ttattttaag ataatggtta atctgcttat taaataatgg aatgtacttt 32580 ttaataatag cacctttaat accagaatct ttgagcatat cagtcaaaat tcctcggtgg 32640 tatttttcca ttactaaatt agtttttgtc ttaacaattt tatcaagttc ttcttgaagc 32700 agtgctattt catcagcatg gtcaataaac tcagaagatg ctttttctat agccgcttta 32760 acctttttag ctttatctac tgtcgtgatt agagattgct ttttattgcg aatatcattt 32820 gccaacgact gttgggtttt aatattatct cggtattcat caacaagaac ttttaaatta 32880 tcacgatgcg ttgaaagctg ctcaaacgaa tgcgtgcatt cagaaacttt atctttaatt 32940 ttagaaacaa ctttatcacc ggaactcaat tgtgacaaac aggttggaca taatccacct 33000 tcgtgataca tattaatgac tttattatac gagtcaattt tcgatttaat taaaaatgct 33060 tcttggccga ttttattaaa tgcatcagtc gggtcttcat ccaaaacaat attaactaat 33120 ctttcattag cttcttctat ttccgatttt agcgttctag cttcttttgc taaatcatca 33180 tacatatttt gcagacgagt aaggttgtca cccgttaatt ttttctggcg ttcaacgtta 33240 tcattatata ttttaatttg ttggataata ttatcttttt taacatcaag cacctggttc 33300 tgcgaattta attcacgtat tagtgcttta ttaagcttat ccatttcagc taatgttcct 33360 acctcaagca ggtcttccac aagctttctt cgcgcagggg tcgacaaacc catgaaaggg 33420 gtataccctg ctgtaccaag gacaacaatc tgcttgaaac tggcatatga cattccgata 33480 agctgttcaa attctgcttg gaaatcttta ctgctggcag attcattaag acgtgtaccg 33540 ttaacggtga tttcgaaaac gtttggtttt tgtcctcttt tgatatagta ctttttctca 33600 tcatattcca tccacagttc aactaaaagt tctttcttat ttgtgctgtt tattaattga 33660 cctttcttta catcacgaaa tggcttgcca aaaagcccaa atgtgatggc ttctagcata 33720 gtagacttac caccgccatt tcgtccagta ataagagttt tttgaacctt atctaattga 33780 atgtcaactc cattttgacc aactgacatt atatttttat attttactct attaagttta 33840 aatgatttca ttttgtatcc aattgttcac aatgaagaaa attctttaac taaagcctgt 33900 aatgaagcct ctattggata tccattctta actaacattt tcctaaacat tacatgttta 33960 ggacgattat atgatatcca caattcatac aatttatctt tattatccca atgatagcct 34020 tttcgtcgag atgctatatg agcttttcta atctccggat ttttccaact agcagctact 34080 gaatttgata tagctatttt atattcaggt tttgataaag cagcacgaac agccttttgg 34140 tgtttaattt tattttcttc gttattaaac cattcccttg aagccattga aattttttgt 34200 tttgttttaa aattatttaa tctttcttta ttatctttcc tattttttgc tactgaaaaa 34260 tattttaatg ccctttctct agcagcattt ctattttgcg gatttgaata atactgttga 34320 agcctttttg atattgtgtc acttacatct tgttttataa aactatattc agcagctatt 34380 aaatcaactt cggctaaaga taaattttta tatgtttttc ctgacatcat tctatttaaa 34440 gcatttaaca tttttccatt tttacctttt gctaataaga agtgtgcttt aaaatgatta 34500 aaatgactta aattaactaa attccatgta gattttaaat attcaggaaa tattgattta 34560 ggaagcacgt ggtgtgcttc cgttttacct ggagttttaa cagttgaatt cacagaaata 34620 aaattaatgt aagacttggc gtcttcttca ctcaacgcta atttttcaac taattccttt 34680 attaaaaatt catcattaat gtcaagttta aaattcttca caaaagattc cttttaatgt 34740 atcttttaga ccattctatc atatcatcat aatctaaaaa gtattcatca aattcagcca 34800 tgcaaacaac accttgtgct gcttttgatg tgatataaat tattccaaca tatctagaat 34860 cttcttcggt ataatcaata tttgctatga attcatcgtt aatgtcaaat gtcgaaaact 34920 tcacaatatg catccttaat acaagataca gccatatctt gtaatgattt aggtgtgtca 34980 ttatctaaaa tgttgaagtt aaaagataca gcccagtcag tgcagaccgt aaccttttta 35040 atacaattat cttcaacctc tagcggttca aaccaatatt caataatttc tttatgccca 35100 atatcatctt ttacttcgca ttcaaaatgc tgactcatca taacattttt aaattcatca 35160 aaagtcattg tgttgcctct acatatagct gattcgcata ttgaataagt gcttcacggt 35220 cagaatcagt gatgtctgga attgcattaa tgtattcttc catcaacgtc tgaagagatt 35280 gaacttcaac ttcttcactg tcatctgact cgacagagtt atcaatcttt gacacaactc 35340 gtaacgaatg cacaactttt tctagttcag attcgaactt cgtcagattt ttgtctactt 35400 cagttactat aacacgtact gatagatttg taaaatcttt atagtcaatt tttcccttaa 35460 atggatattg aattcgacga tgccaggtag tgttgtttgg aataaattcc attcgttctg 35520 tttctgtgtc aaacatccag aacccacgag ggtcattctc gtcacctgca gttagtgtcc 35580 atggtgtccc aatatatctg acgtttgcag cctcagaaat agtatggaag tgaccagacc 35640 acacttcttt ataagtctta aggaaatcag gttcaagacc gtgagatttc attcctttat 35700 aaaaataaaa tccattcagt tcccagtgac caacacaaaa agaagcagat gaagttttga 35760 tgtgttcaag aatttcacca gtattttctt cgcacatcca aggaattaaa tcaatcaaac 35820 acccgtcaaa atctactgtt gtaggcttat catatacttt aacattagga tatttagcca 35880 aaagctcagt agaggcattt ggatgcatta catttttgta gtggagatcg tgatttccta 35940 caatagtatg tagggtaata ccagcaccat caagcatttg aactatttca cgggcaaact 36000 ccatagtttt atgcgtgatc gcttttcgca catcaaaaat atcaccgtat tgaatccata 36060 ccgtaattcc atttttctta gaatattcta tcgcttgctt aattccatca atttgaatac 36120 cgcgaatcca ctcatcatca gctttaacgc ctaaatgcca atcacctaaa tttaaaattt 36180 tcatatatca agaaccgtca ttgaaatgca aaataaaatt attgaaataa atccatctgg 36240 agtgctaaag aacccaatcc aacatgctct agtgaataga taaaatgcaa gaaaaagtat 36300 cacatatcca agaaatatca ttatatcaaa ctccgtataa agctaaaggg ccgaagccct 36360 ttattttgta ataatgtcaa actgttcttt aaagcagaag cttgaatctt gatgctgata 36420 caaaaattca taagcttttt cacgttcgcg gtcataaaga gttcggtcag atgacagttc 36480 tttaatacgt tcaaatgttg attccatgtc attttcatca aaccaaacga taccgctatc 36540 atgagaaatt aatggagtat tatcaacacg gaattttaaa ttttcgcctg tagatttcca 36600 aaataccgga attgttccac atgcaccaag ctcgagatga gtatattcta aagaacgttg 36660 tagatatttt ttatccaact tactcaactg ataaccaaat ccggatttac tcatgcgttc 36720 aagcatttcg ctatttacat aacggtcaag aatttgcgtt ggcaaattag gagcaatttt 36780 aatttggtct acttgatgaa gacgataata ctcgtatgga attccttttt ctttaatagg 36840 aatgaacgct ggagaacgtt ccagaccttc cataatagta cttagtcctg caggtttaag 36900 atgtttttca tgaaaatcaa acatctgata aaaacctttc catgtagtcg tacgaccaat 36960 ccaacggtta acattcatgt taacttcaga aacatctttc cagtaggttg accgaacctt 37020 cgcaatatcc ataggaggct gaaagttata tacggtcggt gcttcttcaa tatcatcaaa 37080 cagagaaact gtttctggat accattcttt catcaaaact ttattaaaat cgccattatc 37140 agaatgacta aaaataacat cagctcgacg aacagtttct tctaatccca aatttcggcg 37200 caaagaaaga gaagaatggt catgttgata aactacaaca cgaaccgaag gcttaatgtt 37260 atcaataatt tttttatagt tattaatagt gtcttcttcg accgaagtag caggaactga 37320 attgataatt agaatatcac aatcatttac cagcttaagt gttttatcgt attcttttgc 37380 caataaaacc ggaattgaaa atgatttata atcatgcgca caattacgag taaatgattt 37440 atctttagca taaaccaaag ttacttcatg accattttta ataaaccaat cacgttgctc 37500 aagagaaaat ttagttacac cacaaccttc aagacctcga gccataaaaa tacatacttt 37560 catttaatat cctcattgtt ttggtttatt ttaccaaaaa tttataaagc aatataggag 37620 ccgaagctcc tatccgcata atacaccata cagaggctca ttagagcttc taaattttat 37680 acgcttatat gttatagttc cttctgcttt agctttatca tgagactctt taaagcgtct 37740 catcatttct gctttagagg aacgaatttt attataatct atttcagaag tctgggtgtt 37800 catctttcac agttgccacc attttttgac ttgataggaa tcaacccaca ctttcatatt 37860 agggtctgct cttacaatag gaggattaac ttctttaatt gaactatcat ggtattcttt 37920 ttcagaaatt ttcacacaaa gatgaccgtt caaagattca gtaaatcctg cattaatttt 37980 aagacgcttg aattttacgt ttgtaagcat caatcatatc ctcaatctgc gatctagtag 38040 tcttccaaag aatactaatg agttcatcgt tatatggctg ttttagaata tcccgacttt 38100 tcttgatagc atattcgtat tgagcaaaat tattgttttc agctgcaatc tgagcgtgct 38160 tataaagacg gttcagttcg cgtttgtttt tagacaataa cttatttgct tttctttctg 38220 cttcaagacg gttcttttct tcaatagaag aaataagctt ttccacttca gcattaattt 38280 cgggtttatc agtcatatta tttctctaat ataaaataaa aatcatcatc tgttaaatga 38340 taccgatagt ttaattctac accattagat ttaaaagcgg tatcatacgg attttctgga 38400 tcaatatcaa tgtcaagagc taaaacttcc ctgagataca ttttaagtaa atagggaata 38460 gcttcaactt caggtatttc ttccaggaat ccggagaggt taatcgttag cctcatataa 38520 aaaatccaaa ctaggagaat cgtctacaac acttttcttt tcagcccccg gtgttctata 38580 ggttgattct tcgtaatgcg tcattttatc gtagatgtct tgaataaaag tttcatctac 38640 taacgcaacc atatcgtcgt cacgactgtc atagacattg tgaacgaagt aactgtattt 38700 ctttgcaact tccttacgtt cttttttaat acgttggacg aatgcattaa aacaagcttg 38760 agttatatat gcatgtgggt ttttatattt cgtttcatca aaattatgaa gccccttaat 38820 agaagcttct ataccatctg caatcatttc ttgtttccag gattgggtgt atcctgaaaa 38880 gttgaaacgt ttagataagc cttctgcaat aagcataatg gctaatccga tagtatcatt 38940 ctgacgaact actttatttg gatctttatt atttgctaat tctgttttcc aatcaataat 39000 agcttgtaaa agctctttat tgtttacgta attatattta ggcttagttt ctgacatttt 39060 cacctcttag ctcaattcat agatctatta tatcataata tttgaagatc tatcttaaag 39120 catagaggat atcagttatc taagtaagca gtatgcttgg aacactttct ccatcatctt 39180 tttaaattca tgaatatcta tgtaatgact agttaaatca gcgtgatata aaaagtctaa 39240 aaacttttca tgcgtgctaa catattcact ttcatttaat tcagaaacat ggctttccca 39300 atatccaaca ccagtcttat ttgggaaaaa tgaaattttc atgtattgat caacatagaa 39360 aatgccataa ttttcaatag taatagaaat attaataaat ttcatacatt catcaactta 39420 gccgcttcaa gagctgcatc tagtgaatca aattggtcaa catattcaat caattcgccg 39480 taattagcat ataaccacca ttggctaaat tcatactcaa ggatgaatcc gtttccttca 39540 atttgagtta aaccaatgcc atttgtattt acttcatatc cagcaagacg caaatcgtta 39600 ataagagctt cgttcataat tataccttag taattttcag gtctgcaaat tttttcttgc 39660 gttgattttt catgcgacga atagttttat cggaaatttc atgcttttga taagctttag 39720 attctacacc aaaagcttta acatcaaatt ctgacaagat atattgaacc aacaattcac 39780 ggacagtgtt gcgtccaatc ttctgatcat tctgtttcat cgtctgatga agttcttttt 39840 cccatttatc caaaatttga ggagttacaa tatcgccttt ttctagcaaa gaaactactt 39900 tatcatatgc gtaagaattg atggcgtttt taatttgaat agtcatacat tatcctcaat 39960 tgcgttaaaa ttttattatc caaaaaaggg ccgaagccct tagctaaact gtttggcacc 40020 cttccagcct tcgtacatca ttgcggctga tattaatatt gctcctgagc aacttgaata 40080 tttgtgattc caaaaccagt ttagaaaaac ttcgtcatca ataccttgag ctatcatatt 40140 ttcaaagaac tgacgacgag cttcagcaat tcgttgcgat aatttagatt caggattcat 40200 ttaaattttc cagttaccat tttcatcaat aaatttaatc cagtcattta ctgaccactt 40260 ggtcgtatcg ccctttggag caacatttaa agtgtataat ccttgtttaa aaagcattcg 40320 tttgatattc atattttcct cagctgtaac gatagcactc gtttgattta cgcttagcaa 40380 ctcgttgaga agtattataa tcaaaatcat catcaatgta aactgatttt ttcaactttc 40440 ttacttcacc acgtaattgg cgatttagct catctttaac ttctgaatca atgcctttca 40500 ttctacgcca tttatcagag cgaaaaatgt tttcgacaat atctttatga cttacaccat 40560 caggagcttt acgctttccg aaatagtcat aatcacgaac tttcaagtct ttacgacgat 40620 acgttttacc catggagttt aatttcctta gcaactgaac taaatacagc acggtcacaa 40680 atcatctgtt tatgtaactt gagtataaga taataaactt caaaaccgtt tacataagta 40740 acacgaacaa cattaccatt aataaaataa tattgtccct tttttaattt ctttatcaac 40800 cacaaccata tcaaatcctc aaaggcaatt catgtgttaa taataccaca gtttgaactt 40860 cttgtaaaca actttgtgaa aattatttta gggaatgata agaagggaac gataatatac 40920 agaatgtgag aaagaaaggc ccagagggcc cgtcttagtc ttctatgata tctctatcat 40980 atccaagtga aatgagagtt tctttgaagt gtttaatgtt cttttgtcta gaatcattaa 41040 tgaaaatgac tggataacga atgttaagag atgtaaatcc agcgcgttta gcaagagata 41100 caatcagtgg acgatcatac tcgatcttac cattatttgt aagaacttta tagaaagtaa 41160 aaggagcatt gagctccttt agaagttttg taactgattg acatccagga caacgaccaa 41220 cttcatctgg aattccatag acttcaatct tattctttaa gttcgagttt tgttccacga 41280 gaaataattc cttgataagc ccaatatggc gggttaacag aatcatcgcc agaattttct 41340 tcaggaaaat aaacctggat aacaaatcca gattcatcaa aggtaaaata aaccgtaggt 41400 aattcaccta acaattcagc acgattatta atttcttcga gttctcgttc acgtccggcc 41460 caaaaactag gatttagact acattcatag aaataatagt cattaccgaa catatcaaaa 41520 ccattccaac tctctaccac ataccgctca aaactaatca taattaagcc tttttatcaa 41580 gaacagcatt cagtttgcta gtaattttat ccagacgctc attgaactcg ctagaagaca 41640 gtcctttttc tggagaaatc aaactaatca cgaaaaatat agcaataaaa ggaataagga 41700 aaatagctcc aactgccata aacagaaaga atgttacagt tgtaagaaaa tcagctaaac 41760 ctttacgaaa tttatacata ttttaccctt aattgattaa ccaagcattg ataagcacta 41820 aactatactg tgaataaaat tctggaccaa aatgaaaaat catatcattt atagtatcca 41880 taatataatt caatttaatc atgtttccac accccatcgg tatttgacca aagtcgctga 41940 ttatctgatc ctcgccacag ctttttagtc ggaagatttt tctcatactt cccatcaata 42000 ataacatcaa catatttaag catttctagt tgtttaatat cttcaaactt atatcctgtc 42060 cacaaccaaa tgcttttatt tggataaaga ttttttactg tttgaacaat gcaatgaaca 42120 gcatctcggt tatcaggata gagagggtct cctccagtta tagttaatcc ttctatataa 42180 tcgttattca aacattcaat taattgttcc agcgtttcac cagtgaatgg aacaccattt 42240 ctagcattcc atgttgattt attataacac ccttcgcatt tatgcaaaca acctgtaacg 42300 aaaagaacga ccctgcaacc agggccattc acaaagcagc acgggtatat tctgtcataa 42360 ttcataataa tatccaattt ttccaagctt catcagtaga attacagcgt tttagtataa 42420 gatgtctaga aacttttatg gcatttgagc actttttaat tgaatcatat ttaataccgt 42480 caactgaaac ggttttgcta gttggagaaa tttttccata cattggattt tttgaaccaa 42540 cttgaagtcc ttttaaagct tttgaaagct tttgtctaga ttccaatgac atgggagaat 42600 tctttttacc ttcaataatt cgcttgcgat gaagttcgcg ttcttcttca ctcaaagaat 42660 tgtaatattt tttaacaccg tttgatatag ataatttatc tttctcagac cgctctccag 42720 ctaatttact tctaacatct tttcgcttca tagctatgct tacggcttta tttaaatttg 42780 cttgatgctc tggcgtacgt ttatatttct ttaaagcacg tgaaatagct attttagttt 42840 cttctgttct ctttttacct ttatttgcta aactattttt gcggcgatgt tcaagtgtct 42900 gttcataggc agttccacct tttccaccag gtttaatatt atatgtattt tcttttagac 42960 aatactcttc ggttacaagt tcagcttctt tatcatacat ttgtttttca ttatcaaaaa 43020 catgtaaaat ttctttatta aaattttttc taccatattt taataaagcg gcacgaatca 43080 atgttcctga ccccatataa ccgtcattta tgttatcggt gctatgcgca ccgatatatt 43140 cctttgaatt aattatattt gttattttat aaattatata atacctatgc atgttttact 43200 cgttttacca tttctttcat tttacctaaa ttccatggaa caacgctagg agttccaaga 43260 tatccgcatg ttcttcttat tgtgttcatc tttttaggat cagtttctcc acaaatagaa 43320 caaacaaacc cgttttcagt aggagtcatt tcatgggtac ttccgcatgt aaaacactta 43380 tctactggca tgttaacacc aaaataatct aaatgttgtg cagcataatc ccacacggcc 43440 tcaagacctt ttaagttatt tttcatatca ggaagttcaa cataagaaat gtgaccacct 43500 gtcgcaatga aatgatatgg cgcttcacga gaaatctttt caaacggagt aacattttct 43560 tctactgaaa cgtggaaact gttagtgtac cagcctttat cagtaacatc ctttacactt 43620 ccatattttt ctgtatcaag tttacagaag cgatagcaaa ggttttcagc aggagtagaa 43680 tacaagctaa aagcaaaacc agttctttca gtccactgtt taagatgagc attcatttta 43740 gttaaaattt cttgtccaat atcacgaccg acaagaatat tcaattcgtg aataccaatg 43800 tatcccaaag acactgaact tctaccgttt ttaaataact caattatgtc gtcatcaggt 43860 ttaagacgaa ccccaaatgc accttcttgg taaagaatag gagcaacagt agctttaact 43920 ccttttaagg aactaattct acacatcaaa gcttcaaaac acaaatccat tcgctcattg 43980 aataattcag taaatttctg ttcattgaat tgtgttccaa tataagaatc taacgcaata 44040 cgaggaagat tcagtgttac aacaccaaga ttattacgtc catcaagaat ttcattacca 44100 gtcgaatctt tccatacgct caagaaacta cggcaaccca ttggagaaac aggaacagat 44160 gaaccagtga tagctttatt gttcttagct gaaataatat caggatacat ccttttgctt 44220 gcacactcta aagcaagctg cttaatatca tagttcggat cgtctttata aagattaaca 44280 ccttcttcaa cgaacataac aagtttaggg aaaataggag ttatcccatc acgaccaaga 44340 cctttaatac gatttttcag aattgctttc tgaatcattc gttcagtcca gtcagttccc 44400 gtaccaaatg taattgttac aaagggtgtt tgtccgtttg aactaaagag agtatttact 44460 tcatattcat aagcttggaa tgcatcgtat acatcttttt ctgttttaga ttgagcataa 44520 ttcaatgcat cagcgatttg ccatttttct gcatcctcaa tatgttttgc ataggtgcgt 44580 ttaacataag gagaaagtac tttatctaca ttagcaaaag tcgttccgcc gtattggtgg 44640 gaagcaacct gtgcagtaat ttgtgccata attgcagtag caacgccaat tgatttagga 44700 gtttcaatct gcgcattacc tagcttaaat ccgttctcaa gcattccttt taaatctact 44760 aaacaacaat tagtaaatgg aagagcaggg gaataatcaa tatcatggaa atgaataatt 44820 ccgctttcat gcgctttcat aataaaagac gggaccatat ttttggcaat gtgtttagac 44880 acaataccag ccataaggtc ccgttgagtt ggaaaaacac gagaatcttt attagcattc 44940 tcgttcaaaa ggtctttatt agttttatga atcaatcctt caatttcttt ttcaattgtc 45000 attttaaact ctttctaagc tgcttcttga atgaagctat taattgtgtt ttggtgtcag 45060 attcattata ttcaaatcct ctttgaagca tctcggccat catttcctct tttcctaaac 45120 gagaaaattc ctttgattta tctccaacga agttagggtg aatattattt tgggtgtaat 45180 cggattttaa ataagtaagt aaattttcta accattcaag ataatcaaca ccttgtccct 45240 ttaagccaga acgattaaat ttatgcttca tttgaccttc tgcggcattg cagagattac 45300 aaagcaatcc acgtaccttt cctgcttttg gtccatttaa ttcatggtca tggtcgaggt 45360 gattagcttg aacgtcagga tttagttctc gttggcaaat taagcattta ccattttgtg 45420 catcataaaa tttctgtttt tcttctttgt ataatttgcc agtcaataac ataataaaac 45480 ccttacctta aatagataag ggtatttatt atttttcaag tattgtaaaa catttgatgc 45540 aatcgcttat attgctgaat cattcggtca gaaaaagaaa tttgagtttc aagccattca 45600 atgtattctg cggcagcttg catcaggtta ccttcatagc catcgttatt ttcttgcgca 45660 gctaatttag ctaatgcgta tgaaatacgt tcaccttgaa aatcggcttt aggcttctga 45720 acaacttgat tagttcgctc tacaacttct tcaatttcgc cattttcgac tgattcagta 45780 ttccataagc accaatacgt aattgactta tcatagatat taataatctt tccgtcggaa 45840 agttcaattt caataattcc agtatcaggc tctatatcat cttcacattc ttttgcaagt 45900 tcacgaactt taaagacagt acctgcacta agttccggcc agtaattaca cagccctgta 45960 tcagcacgat taattctaaa ccacttatct actgtaatca tgtcccatct ccatatcaat 46020 taagtcattt atcgttggtt cattatatat tgtttcttca tcagtgtaaa ccggttcttc 46080 cggctctggc tctacagttt cccatctagc cgcccaccaa ggttttatag cgtaatccat 46140 tctcgtactg tctgagttac tacacgttca tggggctcga ctagttcaac agtcggaact 46200 gcataatacc agtcagaatg ataagaacct gaccgagatt catttaccgc tacatgtacg 46260 ttatgttttg gactaaaata aacacactga cgatattgac atttgccgtc ttgtacccag 46320 tcttctattt cgacaggttt aagataatcg gaaaaatcga aatcatagtt ttccgaaaat 46380 gcatcatggt cttcaatgat ttcgctcaga actgcatcaa catctaattt attttcaata 46440 gtcatttttc accaattaat ttcgcaattt attaagttct tcatcatcaa tccaggattc 46500 tagtcctgat ggcagggcac attcaatttc ccaaagaagt tcttcaattt tctgaagacg 46560 ttctagttct tcggctggaa tagcaaccat tgacggagct cgtgatacat taatatcgta 46620 aatcatattt accccaattt aaccacacaa tcgccgtatt tccacttaga aatagacttt 46680 tcaccattag aataataaac ttcgagttta gcacgattat ttttaatttg aataaccttt 46740 gctgtcatca aagttccata cccataataa actgcaactt catcacctac atataccgcg 46800 cttccgcggt aatcatggat ataatcagtt ccttcgagaa tcatttaaag tattcccgca 46860 attggtcaaa tccaccaata tgacttccat caggagcaaa tacctgaggc atcgtcaaac 46920 caatttgagt atcacgacct agtttcgtta gaagctcagc gattttctca tcatcaaaaa 46980 cacctttttc cggcataatg ttgataaatt caaacggctg tttcttcaca gtcaagagac 47040 gttttgcatt atcgcaatac acacatttat ggatgttgct atcataacca tatactttaa 47100 acatattatt ccttaattcc tagtacttgt ttaaaagtct cgtcgtaatc aagactttga 47160 cctgtttgtt ctttatgttt gtatataata tcacttactt ctgatagcat atttttatat 47220 gaacgagtta aagcagattt aagcacgctg tatctatcag gaaatttacc atgttcatta 47280 taataagcta ttgctaattc acggactgcc ttttcagcaa tctccatata ttctttacgc 47340 tttgtcattt taatccaaaa tattattagg cattggttga acactcgcaa gttctttaaa 47400 gaactcagta gagtcaggta atttaaccat ttccggagca tgcttactaa atttatgttt 47460 gcaatgacgg catttatatt caagttccgg tttacgccag ttaatcaatt gaacttgttc 47520 agtaccgcat tcaggacaat taggaacgtt tttagaagcc ctttcgcgac gttcaaccat 47580 aaccataata gcatcccagg ctggaggttt aaaatctaaa tcatcacaac catgaatctt 47640 tccgcgcatt tccagatcgt cttcttcacc agccataata attttaatta gactggaatt 47700 acttgaagct gcaatatctt ctaatagacg ctttttcatt tcaatacctc aatagcatta 47760 cgtaaaccat ttgcttttgc attaagagct tttaacaatt tagtgtgttc ggcaatctga 47820 gcttcaactt caaccagtcg agatttgaga tattcacgtt cttcactcat gttatcaatc 47880 ttttctactt taggctcttt tacaactgtc ttatatgtat taggattctt cagtttaatt 47940 agaatacgtg aactgtataa cattgaacca ttatcttcga tttcgtcata catttctact 48000 acgtccataa tttttaacat catgcgaagt ttataagaca acgaacgaat agttttgttg 48060 tgcttattaa tttctctagc tgtcatggtg ccgagattac gtgagtaata ataaggaacc 48120 tggatattaa ttaatactga tgaaccacct ggcttgtgtg ttacttcatc agcaataacc 48180 cagtccttaa catgaactgt atttgtacgg tcatcgcctg cggtaaatag tttgcgagca 48240 tgcttaaaaa gcatattcac ttgggtattg aattgacaag caaatttatc agcaaattta 48300 gtttcaggaa tggtagataa ccaatcagct aaatgggtct ttttaacatc gttaacaata 48360 gtaaattcaa ccaaatcgat tatagatgtc gcagatttaa tgaagcttgg cttcataaag 48420 tttttaatgt tatcgcgagc tacagtagaa gataacatac gagaacgttt aaaccattca 48480 agcaaattgc ctaacgaatg agaataagcg ttttgagtat ctttacagat atgattttcc 48540 tggccaacat attgaaggaa atcacgaaga atattattaa ttactgatct gtgtccgatc 48600 tgataattgc ggtgtttagt aataagactg tcaaaataat caatataatg tttacgagtc 48660 atattaatct cctcagtaga aagtaagaac attataccac atccttgtgg cgaagtaaac 48720 tagtttagtg catttagtgc attgttcagt ttagaacgtt gcttcgtgag atttttgact 48780 ttttcttgag ctttttctag catcttttca gcttctaaca cttcattagt tgctttaacg 48840 agttcatcat ctactgcctt aagggacttc tcaatcgcat ccgcgtgcca tttttcaaca 48900 ggtttaagac tcggattttc aacaggaaga aaattcgctt tattgaattt ccatgcatcc 48960 ttattacctg aactatacat ccaaaattta ggatcgtttg atgagtaatt ggataaattt 49020 aagatatctt gcacttcctg ctttttctct tgcgggattt cgtcctttct caaaaaatcg 49080 tatttaaatg aaacgatcat atcaagttca tatattgttg tgtctaattt aaatcgctca 49140 aaacgaggta aaatcttaga ctgaacagcg gcaacaacat ccatatactt aaatgcttct 49200 gccaactgcg atttaaggca ttcgcaaatt gaaagagaat tttttgtatt aggtttaaag 49260 ctaattcgtg cagttctgtt attttctttt aatggtctta cttccatctg aagagtataa 49320 ccatcaaatt tcaggttctt taagttaatg tcagaacctt ttaatcgact agccgtcgac 49380 aaaatttgct ttaattgttt acggaataga gcaataaatc tccattcaat acgataatga 49440 tttggattaa aaaatccaga tgataaatcg accttactct gaccaacgcc ttgaacaaat 49500 agaggatttt tataatcaat agttttacag aaatcggtga gctgctcacg agccgtcatt 49560 tgtgtaatat accccgcttt actaaaatga cgtaaccatt cactgctatt catatattta 49620 aagtgaatat cacgattaac tttatcaggg tctaaattat tttggcacaa aaatgtcata 49680 acatcacgag tatagctggc attacgaacc atatcttcaa tttgagaacg agttttcatg 49740 gtgttcctta agatttaagt aaatcgacaa ttttaattaa cttttcacgc tcagatttag 49800 ctttactact cagtccagat agtctgaaaa tttcatcatc atattgttga atagaaatat 49860 tcagctcttc aatctgttta ttaaaataat caatttgttc agaatgtttt tcgttactac 49920 gaactggtac aggtttcgta ggcaatttag ttaaactgga ttcatccggg cgataaatta 49980 aaatacaact tgaaccaatc gggcattttg caccagatga atattctaat gttccagctt 50040 cttttaaaac ttcaaaagct aaacagagat gatgccccat attaacataa tctgtagagc 50100 gagctctgat gtaataatca tctccgcgaa tactaaattt aaagcattta aggtcttctg 50160 tattattggt cttaaaaatc atttgtttat ctagaccttt agctaatcga gcgcctaatg 50220 ctaataatcg tcgttgattt ttccacaaat ccgcaatcat ttgatcgaat gataattttg 50280 gcattagtcg accataaagg tcatatcctt tattataatt acgaaggatt tcactcgcat 50340 taatgcgaga caacgctcca attttattaa gggctttcat gatacgatta gataaactca 50400 ttccagaccc gtttgttcgc tgtagatgtt tttctaatcc aaatccaata tcaactttaa 50460 acttatctaa aatttctgca tgaacatctt tgtcgataac attcaaatcc aaagttgggt 50520 taaatctatg aaaaaattta tctggctctc cacggcgaag tacagtccat tcattcaatt 50580 ttttattaac taaagattta attactgcat tgacattatt aattactact gacatatttt 50640 cctcactcat tttcaatttt actaaataca cagaatatga ttgaacagac tacataagca 50700 ccacacacag attgaactaa taccattcca aagaaccaga caatattatc aaaccatgtc 50760 tgttttacgt cgaaaggacg taaacttaca gtaatattat cacctttttc tattgaagaa 50820 tacatctctg gggaaatata ttcactaaat ctataaccgt ctttgagttc atatacagca 50880 ataaacgata aactagaccc ctttccttga gttcctgtaa gggtattaac tacagtaaca 50940 tcataatctt tataatgcat ataatcatta atagcataat aaccatatgc aattgctata 51000 cataaacaac atatcaataa attcaatctt ttaattatca actgtttcat aataatctca 51060 attaaaaggg cttagaacca ttataccatc cttggtataa agcggttatg cgagtaccgt 51120 ctttaaccgt tcttcaaact tccgaagagt attttggcgt tcagctcttt gctttttgta 51180 agtttcaata cgctctgaaa tgagagtgta tcgttcattt actgattctt tcataaaatc 51240 aggaatttca cgagaagctt taatctcgtc aaatttatca ataacagctt gctcttcagc 51300 aattaagtta tcatacatta aaatatcttt cttgatgaac tcaatatctt cttgagttac 51360 acgagataat ttagatgctt tatccttttt gtactgttcg ttagtatcac gagaccagtg 51420 taatgtacga tttttattcg tatttttgta aatttctaca ataccgatct catcaataat 51480 aacgatccaa ttccaacgcg atttgtaaat ttgtcctcca tcaacagtga tttcacctcc 51540 gattgagatg tcattaaaga acttgctttg tgcttctgat ttaaatttac catcgttgta 51600 atttaccagg ttgaaaatat ctttagcgtt cattttgtgt tcctccgtag ttgatagggt 51660 aataatacca cagaggaaca gtcttgtaaa ccactaaaag aaacttcttt cacaattttt 51720 tccactgaac catgcgctca ctgctttctt agtctcagga gcagtgttat ccataaacca 51780 ttcaaaggca gcctttttat gattctggag ggcttctcgg gctttaatct gctcacggtc 51840 tattaacact aacatatgag cctttcttgt caccatgggc ttcttatgat tttttgaata 51900 ctcccaatca tttgtccatc gcattgttgt tgcgaactga aatactgctt ctttaatttt 51960 agtttcgtaa atttcacgag cctttgagta taacatcact acctccattc accagtttaa 52020 ttctagtcat ctttttaatg gcagtccata taatctattt ctgaactgcc tttttgtcat 52080 agaagtcctc ttatgaatta tttcagaaga gtaacctcag cgatttcttc ccaaccgttt 52140 ttgtcggtca taataaagtc agcaagataa agagcagtac gcagtgaaac attgcgtaaa 52200 cgattaacat tgactttcat ccatgataat gctttataag tttcttcatc agaaagaccg 52260 cgcttttgca tcatgtcagt tgaaagaata acatcttcaa ccctgaccat aatttcttca 52320 ttagtgtgaa cacccaaatc caaataaact gagcgggaca ctaatgcttg taaatgtgga 52380 gcaagtttag taccacggtc taattcgcgg tcaatatcaa cgtttgtgat aaaaacaata 52440 gttcctttaa attcaaactc gcgctcaatg cctttttctt ctaagtaaga agatgcagtg 52500 ctccagcaga ctttacgggt ctctccagtg tccagagcag cttttagaag attaagaatg 52560 tccatatcag agaaaacatc cacatcatca atcaaaagga cagaattctc ttcacgatta 52620 ttccaaagct gttcataaag accaatacca gagattttac cattaatgct tttatactca 52680 atgtatccaa tatcatttgc tttatttaaa gctttatcta aagaatacgt tttaccaata 52740 cctgctgctc ccgagataat taatgaacga atgtttccgt taataatacc attcgtcatc 52800 attcccataa cattaaatct tttattaatg cgggttttca tatcttcata cgattcttta 52860 acttcttcaa cttttacacc atcatatgaa atgtctgatt tgtaaaccca aacaccgcga 52920 cgcttaccgt caatttcaac aaaaacttta ccatctcctt gtgcatctac cggagcatta 52980 tctgggaacc attcgcctaa gagttcaaaa gttccagaga tttctttacc gaagtagata 53040 ccctcttatt gatagttaca gttttcattt tattctccaa atctatatca gttgatagtt 53100 gtatagtacc ataactcttt atgcttgtaa acagttttgt gaaaaatttt tgaaataaaa 53160 aagggagccc gaaggctccc tatcatttat aataacttct gtggttttca agatagacct 53220 tctcaaggaa gtcatcccag aaactcatgt ctactgtttt aggcataccg ttcttagaag 53280 cttcagtaga tgctgcttct acttgatcga ccacatcttc taaaaactct tgaaccgttt 53340 taaatggatg cttacccaac ttcacgtcga gaataaatgg agcgtcttga agtggataaa 53400 tcaagtcgcc agttttgtaa atttccaata gttggagtcc accacgacaa gcatgactta 53460 gtgctttcca atcaatacct tcattagctt cggctttacg agcacgttca ccatattcag 53520 catctaattt gttcagtgac tgcttaagct caataagaga aagcgttgtc tgatatttac 53580 gacccagcac tgtatagaac gtttgtggac ctgttttctc atgattatgg aacacccatt 53640 cacagaattc gttctctgga agacgatgct taatatcttc aattttagtg cgacgttgtc 53700 cttgtgttcc atcttctcgg taaacattcc gttgatcagg aatttgatta actactttca 53760 atacatcacg taatgcagcc aaacgagaac ctttaacacc atatttagag gcttgtttac 53820 gaacatatcc taaataggat ttcatgttag tcgtataaaa acgagaacgg ttgtcttgaa 53880 taaacttcca cacatcaggc aaatcagatt taaccactag ttcaggtgga gtgtgaagca 53940 tatccaatgc tacagtttca ccatctgctg ctaatttaaa gaaatattta agactgtata 54000 gttcatggtc aatatcatct ttagtgtttt tagatgatgt gttgttagtg tttttactca 54060 tgtgctcttt gacatttccg ataagaatat cgcgagcagg aggaacaaag atttctttaa 54120 aatctacatc agattctggg gtagaagttc cataaagatg actaccgaaa tagcttttca 54180 ttactgtttt catcattcag ccttatattc aataacagga catactttag ctttacgagc 54240 ttttaaaaat tcaacgataa tcgatttctt gggttgaata agaggtaaac ctttattttt 54300 cctatcaatg ttttctacgt gtaaagcata atcctttttc catttataat ctttatattt 54360 ttcacgcaaa tgtacaggaa taacaaatga accaataata agtaaaacaa ccaaaagcgc 54420 aagtataaat gctgatggaa gcaaagtcca taaactacca aaaataagcc agcgctgtaa 54480 actttctgca caaataattg tcagccctac gagtatagca cacccaaaaa tagaaacgaa 54540 aaatgtaggg ataacaatag accaaaagta tgcacatagc gtcttaggtc gttgccattc 54600 gtcgttaaac aatttgaata atttataatg ccaagagttt tcattaataa tcataattat 54660 cctttcattg gaggcgtaac ggttgttaaa tacttaatca tagcttcagc ttctgatttt 54720 gataatgaaa tttcttcatt gttttgacga atagaaataa aatccggatg acggtcacca 54780 ccagctttta aaacacacat ataagtatca acttcgcctt caatatttga aatgattgaa 54840 gcagttccac atgaatgcgg tttttgataa atcaatacagi cttttcttcc accgtttgac 54900 tgttcatagg cttttaatac atcaagcaaa tcagttcttt tatcaatagc taaaatatta 54960 ttttcatctt caatgttaaa tccttcggat acttcataaa gcgttaccca taaatcaccg 55020 atgtcaataa cagcatttac ttttccacgg ctttcaagag tatgacaaat tttcttgatt 55080 tcgtcataac tcattttaat aatatcatct ccttgactaa gaaagatgtc atttttaaat 55140 tcaacacgaa ttaaaccgct tccacttgaa ataaacatat ttcctcactt tgaaatcata 55200 gttggaatga cagaatcaag ataagtcttt agtgcaatag cttcatcttt ggtaaatgtg 55260 acaatatgtg ctcgagaatc atcaatttgg cgaacaagta cgacatcgcc atcttcataa 55320 gaagtcttga catccaaagt cgtagtataa tttgcagcta ctggattaat aatgctagca 55380 ccgcgatctt tagcccattg aagtttagcc ttttcgggtg tttcgattgt ttcagattcc 55440 aagaattctt tcaccttggt aacgaatgtt gcccaattgt tgatagaaag acacataaat 55500 tcagtttcaa tattaccgcc gtaaaggcca cgataaaaac gaacttggag gtcgcctgta 55560 atattagtta caccggtaac tcctgaggga gcataagata aaatcgcagc cagttccata 55620 ggaagaatag taatattatc gtcttcctgc gtcagaacgt atacattatc acgtttttcg 55680 ataaccaggt caccgaacaa atcagttgtt tcaattacag ctttcatatt atttaccaat 55740 taaagtttca atataagaat caagatttac tttagcttct tccataagag ttttgtattt 55800 aatcttgtta gcatgtccgg agaaagctga ttcatcaata attgttgatg tatgaacagc 55860 tctactatac gtctcaatta attctcttaa tttaaaagcc tgctcacttg tcattacata 55920 ctcctttgaa taatatcaat aatgttgttc accaaattat acgtaaacat tgggtaatta 55980 tattgaatca tcacatacac aacaaacaaa actttcattc tcttctcctt ggcagttgac 56040 aagattacta taccataacc ttgccaactt gtaaaccatt aaatgacgtt ttcgataaaa 56100 ttctgaagct ttgtatgagc atcaaccatg attttcattt cttcctttgc gaaagctgtg 56160 cctctttcac gagaagaaca ttcatagtca gaaactgcat tagcatattc ttcaattagc 56220 ttcattaaaa acatctgctt ttcagttttc attattccac ctaatcattt caagatattg 56280 aactaactta gctttggatt tatccaaatc ctttttagct gtttctatac cgtcgtatga 56340 atatccttca caatgctcaa ctgctaattg atatgaatct atttcaacat cacgtgctaa 56400 tttaatgatt ttttcaaact gttcgtgtgt tagcatactt aaactctcgt attatgatcg 56460 ataatttcat caagaaacat atctaacgct tctaaagcat tatcaacttt agtttcaaag 56520 tctttaatgc ctttattcga aatacccgat gaataccaag caaagtcaat cagctcttca 56580 tctgctttac gaattgaagc cactaattcc ttgattttat ctgcttgctc tatactaatc 56640 attattccac cacatatgac agagagaata ttgcacacgc catgtgagtt gcaacttcat 56700 cacacatatt ataacgtttc ttaagaagtt ctaccagttc ttcactagta acttcatcca 56760 tgtcgacgaa aaaatcacca ttaatgatga cgtagatatt tccttcttga ttgagtgctt 56820 caattttcat gatgttctcc tctttatccg atagttgtat agtatcacag ctcaaacgga 56880 aagtaaaccg gtaaaatgaa aaaagtctcc cgaaggagac taatgttatt cgagggaaag 56940 aagatactta ctctggtaaa acatcccagt aatatcatct atcgtgcttt gaatggctgg 57000 aggcatttct ttataaatgc tgttagattg gtctagtatg cgatcaatca ttttaattgt 57060 gtcggtagga agtttactgg catctggaat tgaaggtgtg tattttctac cagaataccc 57120 caaatattgc tcaccaaatt tatcaatcaa atctggcaat tcggagaaaa taaaatcgta 57180 tgctttgtgt ctagcataac ttttagtttc aaaatgtgca gaatgaaaat aagcttgtgc 57240 agccattaat aaacctaagt attcatctgc ctttgaaggt tttccacttt gtgaaaagtc 57300 gctgaatttc attcagtctc caatttaatg ttcataattc tagcgtatga ttgtgccatc 57360 tccgcgcctc gttctataca ttcgaaatca gaagagcacg ggtcattttt ataggtcgtt 57420 ctcataaaac tatagaattg ttcagatgat tctacgcttt tattttcaaa aagcatataa 57480 acatgtctaa taccagattc cataaattta tcaaaatgag gatcgacatt cgcttcaatc 57540 gatggagata aaacaaatga caatcctagc atggcaaata gtgccgttgc ttttaaggcc 57600 ataaaggcct cctatcattt ttgtcctgta tttactttat gccgatgcac ggccttaact 57660 ttatcaaggt atttttcaaa atttcgcaat ctagtatagt ctgccggaga ttggttgagt 57720 gatacttctc gacgcaaagc tgaaatgata tttccaactt ccctacgaat ttcatctaat 57780 tgaagcacag taagattgcg aagttgcttt tcagttaatt gtagcatata taccccttta 57840 gttagataaa cctatttata acttttgcac taaccgagct ttttagttaa ttcgttccag 57900 tgttttctac acaaagaaac ataaatttca tcaccaatac agatttgatt accttcttta 57960 actggtgttc catcttccat taatcgagct gtcataatcg cttttttgcc gcaatgacaa 58020 actgccttta gttcaataag tttatctgca atcgctaaaa gttctttaga accttcaaac 58080 aattttccag cgaaatcagt ccttaatcca taagccataa caggaacatt atatgtatca 58140 acaattcggc ttaattggtg cacctgttca gtttttaaaa actgagcttc atctacaaat 58200 acgcaatgaa tatctttttg tgcttcagcc catttataga actcgaaaat atccatatca 58260 tctgtaataa tattcgcttc ctgtttaatt ccaatgcgag aaacgacttc gcagacagaa 58320 tcgcgagtat caatagcagg cttaagaact aatacaccca ttccacgttc tttataatta 58380 tgtgcagcag tcaaaagaga agcagatttt ccagcattca ttgctgcata agtaaaaatt 58440 aaactcgcca tcttagtcct tagttaaatt ttctaaatat gtttctaaat cattttcagc 58500 tttatcgata gattttacta attcgtaata tgtttcggca tctccatatt cagaagatat 58560 ttcaaaagac aaatcctttt ctaaactaac aatttcacta actaaaaata atatttcgtt 58620 cttttgttcg cgagtaatca taatgaattt atataatcaa tgagttcttg ttctttatta 58680 tcgaattctt tagaaagttc ttcgtactcg tttgcactaa aaggaccgca ttcattacaa 58740 actttttcca attcgctatt tttatccata acttcgtgga taagagaaaa gagtttgtct 58800 ttttgttctt tactcagact catatattaa atcctagaag ttttaagata attcgctttt 58860 gcttaaatat ttccatcgtt aaatgatcag tatctttttg accaattcca atagcaaaac 58920 ccttatttac ggcaagttca attaaattat caatattgcg taaaacttca tagcgtaact 58980 caaaattatt cattttggtt caccttcttt aacgaaatcc ggataaggat taaatccaga 59040 ataaaatcct tcacctttat gattgctaca acccttgttc gagcaatagc accaataatc 59100 gaaatcacaa gccatttcat cgttgcataa agcaaaaaca accggccact tacacttttc 59160 acagtgggca tttttaagaa tactagtttg gctcataacc atgtaacctt taagcaatat 59220 tcttctacat gttgtttacg acctttctta tcaataaagg tatattcaac gaatgttcca 59280 atgtagtctt tatctacatc atgtggacta ttaattggac atttagtacg gcaaatgcgt 59340 tcccattgac gaataattac tgctttgttt ttaggatcaa acggatgcgg gtaatgtact 59400 ttcataatcc accactatta aatcaatatc aggagtaaac atgtcgatta atttagaaac 59460 cttatcccaa tcgccgccag caataccaca acctatacgc ggaatgtaaa ttactggttt 59520 gt; atcaagatta ggacctggtt cgtattgcgt atacaggtta tagcatatgc caaaaccatt 59640 aggtttatgt ttaaaaacaa tagacatatc gcctaattta tcacgagaac cgtactcagt 59700 agtggtttta tctatttcta aaattttggg ataggctctt gctaattgac ccgctacgcc 59760 tgaacccata gtatgaaaac aattgcaccc gtgcgcaata atattacctt gaagaaatag 59820 ggcgacaata tcgcccttga tatattttac aatcatctag tactcaatcc tcgattataa 59880 gaatctacta aacggtcaac cattgaatga caagcggctt tatctttctc ctccgcaact 59940 gaacattcta aggtattcca ctttttagca tatcgtttta acaatgtatc atttttgtat 60000 ctgcttgatt tatctctttc tccgtcttta tatgcatata ttaatttctg cgcaaattca 60060 gcttggcatg ctttattttt cccacaataa tccgcggcag tacggtttac atactctcta 60120 atttcagtat atgatgtatc tgctgatgca gaagcagaaa atgaaattaa tcctatacat 60180 aaaaccaaaa ttttagtcat ttactatttc caaaagttta ttatttttaa ggtaattagc 60240 cttttctagg acttcagaag catatttaga acctgcttta acattccatc ccgaattata 60300 agaggatatc gcctttctta tatcgccctt atgtatattt aaccaataag aaagttcaat 60360 gtacgcccag gaagctgaat tggaccgttt attcaacatt ctttttattt cagcatcggt 60420 catattataa ccaagttcct taactcttgc tcgcatggtc ggcaaataat tttggaacat 60480 tccataggca tgatgctttg gtttagattt taaattaact ccggcagagc tttcttgcca 60540 taaaatagca gccattatat gacccaatcc gctcttgtgg atatttttgt gtgttttata 60600 ttttccatcc ttagaaaatt gttccccgaa ttgatatgcg taacgcatgt tatcgagttg 60660 gacattactg aaagtatgct cggagctatg tgccatcatt gaaatggcca atagaccagc 60720 gagtagtgct tttctcatgc ttacctcatt gagttttaat tactgcttta gaagcctttc 60780 ctggtaaacg acgactgttg ataattgcca tcctgcactg aagcgacggg tctttgaact 60840 ttgcattagg tttacaaact gtaaatccaa gccaaagatt tccatctgtg atttctaaac 60900 gcccagggcg atattcaacc ccatcaataa aatcctcatc aatgtcagga cgcggaggca 60960 tactcaggaa ttcattaact tctaaaacat ggtcttttat tttgtggaat aattcaaaaa 61020 catatgtctc atcaatctcc cgttgaattg cacgatcaag aagatgctga gaatatttta 61080 gatgaaacga tgagactcct gctgcttttg atgcctcacg aatctcattg ttaatttgac 61140 gaaactccga ctcaaagtga cgacggagct tatttcgacg gataaaaact tctgtgttga 61200 tagtcatgtt attctcctct taactgatag aaaaattata ccacagtcaa gaggaaaagt 61260 aaacagttat tctttaaatc taatcaattt attcatagac tttgaaactt cttcacgaac 61320 ctcatgtaga tttttaagct gttcaagacg ctgctcatag taagcaattt catcttcttc 61380 gagacagtcc tgtgaatctt ctttaagata acgtgcgtag tcctggaaag ctttacggac 61440 tacttcttgg aagtcatcaa gactttgaat tttcttagga gcaacagata cacgacgagg 61500 ggcagtataa tactcgtaac caaaccctgc gcttaattga gccattaata tttttcctct 61560 ggttggaaca ctgcgcgaca agcccacata ctagcttctt tgagtttcgt tttagcaata 61620 gttaactgat cgaggctttc agcataattc ttcgcgagtt catcatcttc acagctatcg 61680 aatgcttccc agaattcatc gtataaagca tcaaagataa gtcctaaacg aacttcagcg 61740 tctttgatag cattcacttt accgattttc tcttcagtat gcggcttata acctttaatg 61800 tcttcaatca tatttgactt cctcaccagt acataaatca tattcaacta aacgaatagg 61860 ttcatgaatg ccatatcctt gaacagaaat ttctgtcgta ggataaattc catcaatatc 61920 acccatattc caggcttcat taaattgttg ttcgcctgaa ttactaaacc actcggcgaa 61980 agcatttagc acatctttag aaccttcaat aattatcttt gccattacaa actctcagta 62040 aaggtacgag cgataacgtc gcgctgctgt tccggagtca gagagttaaa gcgaactgca 62100 taaccggata cacggatggt cagctgcgga tatttttccg gatgcttaac tgcatcttcc 62160 agagtttcac gacgcagaac gtttacgttc aggtgttgac caccttcaat tttaactgta 62220 ggttgtgttt caatttcaat ttcacgggca tgcaaaccgt agaaaatttc tgggtctaca 62280 aaagagtcct ctttaaaggt tttagagaca ataattcgtg cttgaatacc atcttcaaaa 62340 taaatagtac ctttatgtgt gccttcaaga atttgatatg ctttcatata aacctcaatt 62400 agaaaataaa tttatccaag attgttcttt aattaaaaat ggctcagaat catatgccat 62460 taaactttgg gtgattagtc ctttaaaagg tccatcaata aattccatgg taaaatatgg 62520 aattttattc attaactgcg cgttaggagc agtgcacaaa actctgcatc ctttgaatac 62580 gcctttttgt aatttgtatt gcttgggata aaattcgctc aaaatgttat tatttgccaa 62640 aatttcaaaa tgattcacca atttattttt aatagttttt ggcgaaaaat aaagatattc 62700 gaaaagctgt gtgtctgtca tcattgcatt ccaatcacaa aaaattgagg acgaactgtt 62760 tcacctgttt cagcattata gcttcgacaa cagtgttgta ccgttttaat atggatattg 62820 taaatcttat ccatatcagg agctttaata ggttcgtcaa ttatgtacaa gatacgagaa 62880 agcgataacc cacggaattt atgaccttca ttaccgataa aactacggac agaatcagta 62940 aataaacgga atcgaatatc atcattagaa taacgcgaaa attccttttt aatgttattt 63000 gcagaaattt tagcgtaagc tgaagtatta gaaagaacaa taactgttcc gccatcatac 63060 aaccaattag cagcaaagtt agtcacagca attgatttac cggattgacg tccaccatct 63120 agtcgaagtg tacaatactg tttaagtaag tcttcaaatg gcgggatata ttcgttttta 63180 caaatttctt ctactctagc atcagaatgg tgtgtaaaag cattcatcag ggatagataa 63240 ggaccggtta aaaatgttct cattttattc tctctaagtt tgggccattc cgtggcgcat 63300 gaattgtcca tttctgcatt tacccattac cgcacttggg ctcgacctta tcacaggttg 63360 gcgggaatcc ctcacagaat catgaggtcc aggttgttcc catattattt gaacgattta 63420 acgtactgaa tagaaccctt actattcacg aaagcgattt taccattttt gttatacatg 63480 gtagcagtac gttgataacc ataagtttgt ttaccagatt gataaccaac taatgcaaaa 63540 ttatcttcac ccattttatt ctgcttagcg cgaatgcgtt catggccatg tgccataaga 63600 accttagcat cacccgttgc aatggatcta cgagtttttt catcttcaac tgtattaaca 63660 aagtcgtcaa atgaatcaaa tttagcatga gatttattat acagttttcc atctactgca 63720 taattatatc cttgtacatc catctcaact tctgtaccgt catccaatac agcagtgatt 63780 ttctgtcctt ttttaaattt caaaagatca gtaaaagatt cagcaataat ttgagaatta 63840 atagctgctt cagtaataaa ttcttgatat gttttcatgt gtatccttta atttttattc 63900 tttagggaag tttttagaat atgcatcata aagcttattt ccaatacggc ggaaaactct 63960 agccgcaaaa cgattttctg ggtttttaat catgatttgc atcatataag tacccgcgtc 64020 agaaagagct tcttcatagt acccgttaat ttctttaaga gtcctacgtt taccaccagg 64080 accatcaaca gtgattttcc atttacctgt agaagtgcga cttggcggct caacttgttc 64140 aatccagata taaccgcctt ctacacgttg tcctgcagca gattctgcaa taaattcttt 64200 atacgttttc atgtgtttcc tttaaatatt ttaattagta actgtgaata tactatcaca 64260 gttctaggag aaagtaaaca actttataga tttttatacg cgtcccacgt accagttcta 64320 aacgtggcaa tgactcgttt tgcacggtta ggtgtttgat tataccatct acttttagct 64380 aagttaactg ctgcttcatc ccagcgtttt tgttgaagca tacgtaaaga attagtaaat 64440 cctgctacgc cggtttctcc catttggaag accatattaa tcaatgcgca acggcgaaca 64500 gcatcaagag aatcataaac tggttttaat ttagcatttc tcagaattcc gcgaacagca 64560 gcatcaacat cctgattaaa gagtttttca gcctcatctt ttgtaattac accattgcaa 64620 ttacgcccaa tagctttatc taattcagat ttagcaacac ttagtgatgg acttttagta 64680 agcaaatgac caatgccaat agtgtaatag ccttctgtgt ctttatagat tttaagtcta 64740 agaccttcat ctatacgtaa catttcaaat atattcataa tacctcctaa gtatttatag 64800 aaggtattta taaattaaaa gaggttgttc attattcggt aaagtgaagg acccatcaca 64860 tattgccact gagtgcgagg aataagagca aaagcatcca tctctggaat cataacgcca 64920 tctttatttt caaaataaga ctcgcaatgg caatttctga acatctcatg ctctactgga 64980 atcgtataat aaaacaactg taggtcttta ttactagaat atttaaatac acctaggtct 65040 tctagaaggt ctggattata attgctaaaa ccggtctctt ctaagcattc tcttcgtgct 65100 gcatctaatg cgcttaaatc agaattttct acacggccct ttggaatatc ccaacgatgt 65160 gccatcattc caggcttacg agaaccagta acccgaccca taaataaatc tttatcttct 65220 gtcataaaaa taataccagc tgataatgtt ttcattttaa tttcctgcat tcagtgataa 65280 agttatttaa attttgagta tatttctttt catcaaaaat cttttgctgc ctacgtaacc 65340 gccatggcat ttcaatgaac acgcaccata ttcctgatag tactgctgct gtaaaaatat 65400 taacaagtat aattaaaaga atccaatctt ccgttctgcc tactggactt tctccaaaga 65460 agcaaaatac aaatgatgtc acaggaaaac taataatata ccacagaata accttcttat 65520 ctgtgaacca atcagcgttc gttaacttag cacgaccatt ttgaatacac acgaatttat 65580 catctgttac agtagatggc ttaactgctt gatatcccat tctaaactcc ctaattaatc 65640 gtttctttgt atcttcagaa cagccgctcc agtcaactct atcgactgaa atgccatcgt 65700 ccccatcatc taaatcatac cagcgagttt ttaaaatcat ttgattttcc tacaatcatt 65760 cacgaattct ttcattgatt cattttcaat ataagacatg tagttattat attcttttaa 65820 ttgtattttg taatcctttt ttctttgcca atttatttta aaattatcat aatgaaaata 65880 taaaatgata ctaaagaatg aaaataatga aattgctata gtataatgaa gttcactcca 65940 aacttctatt atatctacta taccgctgac gttactgcgg atgtttaaaa taatacagtc 66000 aatcattaat ccaataagac taccagcaag agctgcagcc aacgccacag caaaaattaa 66060 aaatgactca gaaaaagaat atttgacttt atttagtttt ggcttttgca tcgtgattcc 66120 ttaacaaatt tcataatttc attaaattca tacatattta gtttaagctg gtgttccttt 66180 ttaatctttt tacactgagc tttccattcg cgtacgcgtt tacgataatg tcttccttga 66240 taccagtatc ctacccaatt tacaggtact aataaaagtg gaactattaa tggaagaatt 66300 agcattaaca caagtatttc gccagaatca atatcagtca taacatctaa aacacctcca 66360 ataatcaata gaattacaaa tgatataagt ataacaggac ctattaatac atcagtagaa 66420 attatctgac gctttaattc atacttcaaa ggtttacttg gaaggtatag tgatggcttt 66480 gacatattct ctacattcct taacaaattt ttctagtaat aaatcgcttt caaaattggg 66540 attttccact aatttatcaa aaagatcatc aacaatagtc aaaatattct ttttactaag 66600 aatacgctta ttttcatgct tcgtttcaga atcaactata agagtaaaga aatatttctt 66660 tccctgaaat tttaccgtag tatcaatata gaataaattt gacttttgta aattacgttt 66720 aaaccatgcg tcacttaaac tataaacacc gagataatca aaatcgtcgt ttaaataaca 66780 aactgaccat tcaggagaaa tgaaatcagt aaattcaaca tcaaaatcac atgtcaatga 66840 ataaattgat tcaatattgt taataagtat tccaggacgt attaaagact ttttacctct 66900 agaaaatctt ccagaaagac tttcatcagt ttcatatgaa gaaccccaat aataattacg 66960 tccttctgcc atacgtttaa gagcatttaa taattggtct ggaacatcaa cttgtctttg 67020 gaattcttca aacattgaat tgaaatcact ttgcattttc attcctattt actccaagta 67080 ataggggccg aagccccttt atcattattt cagagaatta atgtattcct gaacatcagc 67140 agaggtagtt tcaaccccag aaatattgcc attaaaggtt tcaactcggg caagagtatc 67200 ttcaatatca accttagtca gcgctgcaat ttcaactaca tcatcagcag tactaattcc 67260 gagggcattc gcggcgcgag tttcacggat atattccaat ttaactgcaa gttcttggcg 67320 agcatcatct aactcaacta ctttcttggc gatttcaatt cgcatttcag cataaccatc 67380 agctttagta gtcaactgct cagctgttcg acgatatagt aaaccaagtt tagcatgcat 67440 tgttacatct tgaccttccg aaagaagctt gcgaatttca cgctcttttg attcggcctg 67500 cttattcttt tcgacaataa gttcacgaat acgtttttct tcattaatag atttaataga 67560 agcagttttt agatctttaa ttttatcaag tagttttgct gctgcggcag tatactgttc 67620 ttcaacagat agatttttag ccatagcaga accaagttta gtgcgaataa actcaacaat 67680 tttcttcagt gtgttcatag tatttcctta ggttgattaa gatttaaaat ccgtgagagt 67740 attagtatta tactctatct tcaagttatg ggctcataat atctcaatca tgagcctatg 67800 taaacttatt tcatattatt gaaattattct tctgcgattt cgtcgttatc atggtaaact 67860 ttagaagaca atttaacata accttcagca gtgaacatgt taatcacaac ctttacagta 67920 taccactgac cgtcttcatt gcccattacc gcataagttt caaacatcgg atgatcagga 67980 ccgataactt taatatcatt cactgtacga ccgaaatctt ctgaaacaca tttcataaag 68040 aagttgaaca gttcgccgta attatccatt tcgttctcca agttgttttc tgtatcagta 68100 gttgatagtt gtatagtacc atggaagaac agggatgtaa acagttttgt gaaaaaattt 68160 ttaaaaagtt ttggggaatt ctagggcagg gaggggaaat caaaggatag gataatatat 68220 tataaagggt agaaactaaa tgatgtctag agaggcctgg aaaggcctag ataccaaaaa 68280 gccccaacct ttcggctggg gctaagaatg ttatttgatt tgtttagcag accaaatgcg 68340 gtctttaata attttttgga tgtcttcaac atacccaaga gagtgagcat gtgggttatc 68400 tttgaaacta taagcacgag ccagtttttg gccttcagtt ttgattacta aaagctcttt 68460 aagaatagct tcatatttgg agataattcc tttaacaata tttttctctt gtgcgacttt 68520 aggatctgct ttaggagcag gtttacctga agcctttgca aaagcagcgc cagtagcaac 68580 taaacttttc caggccatac taactgcatt tcccgtaaat ccttccgctt tcatgtcgcg 68640 tgcgaactgg aatcgcgatt catcagaagc atctttgtaa gaatatttac ccgctgcaat 68700 ggctgctttt gcgacagctt gaatttcggt gctagatgct tcatttaaca ccgcttcatt 68760 taaaaattga gtatatgatt tcatcttatt tcctgtttta attcgtggtt ttaatatact 68820 actatattta taccaaaaag ccccaacctt tcagtcgggg ctaagccttg cggcaacctt 68880 gtcggggttc cacctgctaa ggcaagtgtt tgtacgaaac gccgggattc gaacccggtt 68940 attaagcagt tgacgctact caatattttt aaaaggccat atctcgacca tatccgaacg 69000 ttccgtcaaa aacgctactc ggtttacggc aaagatattt cctcgaatcg ataattcggt 69060 gcgccgtttc tgctgtgata gtaaagagcc agaacacagt aaaactgtgg gaggaaacta 69120 tactccaggg aacatcagtc cgacgactta ccggtagcga cccggtttct tagtattctt 69180 ttaaagcatc aacctgttca cgacgtttac gccataaatc aattacttca tacgcagatt 69240 cagcatttcg aattggacgg catttatata aagacttgtg attttgatat tgtgtagata 69300 acggaatttt atctaaaagg tctttacgtt caaaatattc gtaaccatct aaaccaaatg 69360 aacgattttt gagaaattgc caatgaccaa attcgttttc gacataaa taatctgcat 69420 gctgataaag caaattaatt acacgttcag aaataacagt atcattatga ttaaaataga 69480 atgttaaatc atgaactact aaataaacat tacctttcat attttcctca cttataattg 69540 gtcgaggcag tagggatcga acctacgacc caggacttag aaggtccttg ctcttccttc 69600 tgagctatgc cccgtaattg gggtgaccga tgggagtcga acccatgact acgagaatca 69660 caatctcgag ttctaccaac tgaactacgg ccacattaat acctactcca acaatcatga 69720 tgtcttcaca cgaaattaag agaagagtga tcagttcaac ccctataatc gcgtcaagta 69780 gatattaatg tgacagttgt cacaaatttg gcggacgtga taggattcga acctataacc 69840 aatcgcttaa caggcgatcg ctctgccatt gagctacaca tccaaattgg tggggagtga 69900 tggagtcgaa ccacccgagt cgcaatgaca atgaatttac agtccacacc gctacctcta 69960 cgggataact cccccttaat ttggtggccc tgggtggaat tgaaccacca tctggcgatt 70020 atgagtcgct tgcttgaacc ttccagctac agggccttgg tgctgattga cggaatcgaa 70080 ccgccgacat cctcattaca agtgaggtgc tctacctact gagctaaatc agcaaaactg 70140 gcggaggcga taggatttga acctatgagt cgccggagcg actgccggtt ttcaagaccg 70200 gtgcattaaa ccactctgcc acgcctccag tctccataca aggatttgaa cctacgacat 70260 tctgctccca aagcagacgc tctaccaaac tgagctacac ggagtaaatt aaattggagc 70320 ggataatgag aatcgaactc acatcatcag attggaagtc tgaggtaatg ccattatacg 70380 atatccgcaa atttggtgcg agaagtggga ctcgaaccca caaggaaata attccgcagc 70440 attttaagtg ctgtgccttt accaatttga ccattctcgc gctgggaata aaggactcga 70500 acctttgcat ctagcagtca aagtgctatg ccttaccaac ttggctaatt cccaattatt 70560 aacaaaggct ctctaacaag aacccttgat gatagagggt attaatcagt gcggtatgag 70620 ttaataataa caaataattc ttaaagcata tttaccattt atgataatac atatttacga 70680 tgcattcaag gcccaaagga ttcttgaaaa tatcatattc aagaggacct ttttctgttt 70740 caataaagaa atcaaaattt actgtattaa atttacggtc ttccttcact aatttaactt 70800 gagaagatga acggtcaaca taaacctttt caacttcaaa acatgttaaa acgccataat 70860 catcaatcaa ggctttagct gcttcttgat catatttata tccattttca atggatgata 70920 ctttcgcata aagaatcatt attaaccttt atcaacaata gtatgtgtat gggcatttac 70980 gatttgccac cagtcaaaac tatcgccaaa tcgttttgat ttattgtctt caataatttg 71040 gcgtaattca tcttctgttt cagcatacgc aatcaaatca tcatatccac cgcaaggata 71100 gtaattatcg cctgcgaaca aaagaaaatt tactttagat gggtctacat aataatgctc 71160 tttaggatat ttagttcctt tccaatcagt tacttcaaca taacaataag aaaatccatt 71220 tttactttca acccaactcc acgcttcaaa aggagtatta aaaactctat caggtattaa 71280 attaccttca aaatgagaag gatttgcata atccccagca taaacataat attcgttaat 71340 attcatttat tcacctttag aaattttatc cataacaata gcgattaaac caattaaaaa 71400 tgctactaca agtgaaaaaa cattttctgc tgtagtcaat aatccgcata taaatccaac 71460 aaacattgaa aaactaaatg cagaagcaga aattgcaata gcaacatttc gaattaattc 71520 acagcgtttc attttattct cctcagtagt tgatagggta atagtatcac aactaaaacc 71580 ctatgtaaac aactttgtga aaaatttatt acaaaagatt tttagcaata attttaagct 71640 gagctactga aatatgcttg gctttaaaca aagcagtttc ttcagcaggg gagataatga 71700 ttgtggcacc atctttctta gcggaccatc catcacccag gtaaacagta cctttaactt 71760 cctcaccatc aaccaggcta atcatcggtt taccttcacg tcctttgttt gctttaataa 71820 cttcagaagt aagggtcgct tcagtcaaag tagaagcgtt agtggttgaa gtgaattctt 71880 gataagtttt cattttattt tcctaattaa ttttgacgag gtaatagtat cactacctca 71940 tcagcatgta aacaactttg tgaaattatt ttaaatcatc tgcccaatcg aatttaagag 72000 gctctttgta ttcacgatct aatacgaccg gaatttgtac atcaccgcta aatgataagg 72060 gcccaacatt ataagacaat gttatatgcg gtgtgtaatc atcaaaatca tgtgtagcac 72120 ctagtgcccg cgcatacatg tgtcgacaac gcagatattc agaatctagt acaagtacaa 72180 gagtcgatcc atcttgtgtt ttccatactt ctaaatgtcc agaagaagct acttcaaaac 72240 ttccgcttga tggaacatac ggaacattta ctcttgaata acatatggtc gaatgaattt 72300 tttctctagg aactggatta ggaacacgta aagagcgctg gagttcttcc agcgcatcaa 72360 gtgttaattc tgaaaactta gctgctacat aaagacccgt tgaaaagtct ttaaattcca 72420 tcattcttca tcttttgctt catctgcaga ttcagcagta agattcttga cagcttcaac 72480 gatttcttca actttaatag tatcgccagt gatacctact gcacgagcaa tttcagccaa 72540 agttccttgc agaattttgg attcttccat tagacgagtc gcttggtcct gcgtatcaag 72600 aatgcgagat ttcagagtta cgatttcagc agacagtttt tgttcaatag tttgttcaga 72660 cattatagta cctttagtgt atttttaatt ttagaaaaaa gttcttcaag agaaccatcg 72720 tttgtaatta ctaaatcgcc atcacgaatt ggcaatccag cttctgtaat atgtgtatca 72780 ttggattttt gaccaggacg aactacatga attactgtag cacccatcgc cctagccgca 72840 tccatttcat gatcttgacg ggtatcagga acgatataat aatcataacc tgagttaaat 72900 ttatcaagat aatctaaagc aaataatttt acccagtaca tgcggtcgaa gttattaaca 72960 atcaaatccg tacctagggc ttgcatcaga cgacggactg accattgatc ttcaatatta 73020 tttataacgt cagcaatctt gttaaatgct acgaaattaa ctgcgtcatc aaaaacaaac 73080 acacctttaa ttgggctttt actattaaga tagcaaaatg cttgttccat aatcgtaatt 73140 acttctaatt tagtcagatt taaattagtc tcacgatcat agtcaattcc ttcaaactct 73200 ttacgagtta agcaaggata gtcagtgttt gctgcaaata caccccatgc ataagccaat 73260 gcatccttaa taggaccagc aagttgatat ttaactgcag aataattatt cataataaaa 73320 tctgcagtag tatcttttcc actacgcttt acaccactta aaaagattag tttcatatgt 73380 ttctcctcaa atttagttaa gattataaca catgaaactg aagcattaaa cttctgctat 73440 aattttgcca tctttttcta cttgaaaata cgtataagga atcgttgctg tgcatactaa 73500 ggctgggtct gaatcttccg tgtagctaaa ttctacttca gacaggtcag aaacccaagg 73560 cttataaaaa tttattgaca tcacgatttc agttttacta ttatctaaaa tgtaaagcgt 73620 aatgtattca ggacctgttt tttgggcagt attttcgcct gtaagatagt tactagttcc 73680 tagcatccat tcatacattc ctatccacga cttaagctct tcatcaacta taaatctcac 73740 gatgagtggg tcgtactcaa atgtaacacc tggacgttgc gctcggccta gtccaaatgg 73800 cccagtcacg gtatcagtaa caggtattct aattcctgga ataggaactg actgagcatt 73860 taaagtaaaa gcagatgtag tattactatg tggtattgat actacaaagt tagttgtatt 73920 tgcttggtta aaaatttgtt gcagagcttg cgacatatat tcctcataat gctttatagc 73980 tgttggtggt ataatgggtc taagtccctt ccattcaatt ccatttagaa caaacaacag 74040 aaaagaatgg aagataatag aattagatat ttgaccagac tttgtttgca gagaaacgtt 74100 ttccttttga aacgaactgc tgaagtggca ttaacacaac gttcgcccag tctttcgggg 74160 cgatttcaac taggctaccc ataatattac caggtatata tgccttaatc atttggtctg 74220 cacccctaaa tcctttcact tgactccaat caatttttaa tttcgtttta ttagtaatag 74280 taggtgtatt tgcatattgc tttaaaagct cttctagaaa ttgctgacga gctttaggtg 74340 gaatatagtg caagtttaat ccgtacatta aattatgctt acctaaacca aggtaaatta 74400 tcaaaggaaa tttatcccaa taaggaagag tttctttgtg tttagcatcg taagcaaaag 74460 catatattcg tcccggctga gggcgaacaa ctttatgtcc ttttacttgc ttaatagttt 74520 cagcaaacca ttttctggtt ttattattaa ttgctgcacc ttcattacga attttatcgc 74580 gcaatgtttg tctgaatgaa tttatcataa gcagttgtct ttcttgctta ttgagcttat 74640 tcattggttt tgattcaagc ttttgaatct tttcagctgt tttaattcct gaagcatatt 74700 ttgacattgc cgaagtaaac gtagagtatt tgattcctct ttcttcagca aattgttttc 74760 ctgtcattcc ttttgctttg gcctttttat attcaagacc tatttgaatc catttctttt 74820 cgtttaatga ttgcttaacc tttggaactt ggggagtgct ttcattaatt atttgaaaaa 74880 tagccattat gcccccttaa agccaagagc tcgtaatcca tcttctgtta gaattctaaa 74940 ttttattcca cgcttttcag ctaaagattg tgctgctttc catttgtcag tgttcacaga 75000 ccaggtataa atttcattca taaatctttt cttcgctgcg gttgttagat gtgctggttt 75060 aactggtggt tgtgtttctt ttttaggttt tatttcaata aaaaattctt gtccagaaga 75120 atctttcatc caaatatcca tgaagtatct acgttttttc ccttctgcat tacaaaaata 75180 aggaattact gctgtttcac taccccatgc aataatttct ggatttttat ctaaccattc 75240 aaaaaagaat ttttcccaat ttgatctata cgtaattttt ttagggtcac ctctatattt 75300 tgatatattt ttaggaaccc attttccaga atatgccatt ggattctcct tataaataga 75360 taatatattt ataaacagga gggcccatgc tctttacatt ttttgatccg attgaatatg 75420 cggccaaaac ggtgaataaa aacgcgccga ctattcctat gacagatatt tttagaaact 75480 ataaagacta ttttaaacgc gctcttgcgg gataccgctt acgtacttat tatattaaag 75540 gttcaccacg cccggaagaa ttagcaaata ctatatatgg aaatccgcag ttgtattggg 75600 ttttattgat gtgtaatgat aattatgacc cgtactatgg atggattact tcgcaagaag 75660 ctgcttatca agcatctata caaaaataca aaaacgtagg tggagaccaa atagtatatc 75720 atgtgaatga gaacggtgaa aaattttata atttaatatc atacgatgat aatccatatg 75780 tttggtatga caaaggcgat aaagctagaa aatatcctca atatgaagga gcgcttgctg 75840 cggtcgatac gtatgaagct gctgttcttg aaaatgaaaa acttcgtcaa ataaaaataa 75900 tagcaaaatc agacatcaat tcatttatga acgaccttat acgtataatg gagaaatctt 75960 atggaaatga taagtaataa ccttaattgg tttgttggtg ttgttgaaga tagaatggac 76020 ccattaaaat taggtcgtgt tcgtgttcgt gtggttggtc tgcatccacc ccaaagagcg 76080 caaggcgatg taatgggtat tccaaccgat aaattaccat ggatgtcagt tattcaacct 76140 ataacttctg cagcaatgtc tggaattgga ggttctgtta caggaccagt agaaggaact 76200 agagtttatg gtcatttttt agacaaatgg aaaactaacg gaattgtcct tggcacgtat 76260 ggtgggatag ttcgcgaaaa acctaataga cttgaaggat tttctgaccc aactgggcag 76320 tatcctagac gtttaggaaa tgatactaac gtattaaacc aaggcggaga agtaggatat 76380 gattcgtctt ctaatattat ccaagatagc aatctagaca ctgcgataaa tcctgatgat 76440 agaccgctat cagagattcc aaccgatgat aatccaaata tgtcaatggc tgaaatgctt 76500 cgccgtgatg aaggattaag actaaaagtt tattgggata ccgaaggata tccgacaatt 76560 ggtattggtc atcttatcat gaagcagcca gttcgtgata tgacccaaat taataaagtt 76620 ttatcaaaac aagttggtcg tgaaattaca ggaaatccag gttctattac aatggaagag 76680 gcgacgactt tatttgagcg tgatttggct gatatgcaac gtgacattaa atcacattct 76740 aaagttggcc cagtttggca agcagttaat cgttctcgtc aaatggcgtt agaaaatatg 76800 gcattccaaa tgggcgttgg tggcgtagct aaatttaaca caatgttaac tgctatgtta 76860 gcaggagatt gggaaaaagc atataaagcc ggtcgtgatt cattgtggta tcaacaaaca 76920 aaaggccgtg catcccgtgt taccatgatt attcttacgg ggaatttgga atcatatggt 76980 gttgaagtga aaacaccggc taggtctttg tcagcaatgg ctgctactgt ggcgaagtct 77040 tctgacccag ctgatcctcc tattccgaat gattcgagaa ttttatttaa agaacctgtt 77100 tcttcatata aaggcgaata tccatatgtt cacacaatgg aaactgaaag cggtcatatt 77160 caggaatttg atgatacccc agggcaagaa cgatacagat tagttcatcc gactggaaca 77220 tatgaggaag tgtcaccatc aggaagaaga acaagaaaaa ctgttgataa tttgtatgat 77280 ataacaaatg ctgatggtaa ttttttggtt gctggagata aaaagaccaa tgttggcgga 77340 tctgaaattt attacaacat ggataatcgt ctccaccaaa tagatggaag caatacgata 77400 tttgttcgag gcgatgaaac taagacggtt gaaggtaatg gaactatcct agtcaaaggt 77460 aatgttacta ttgtagttga aggtaatgct gacattacagta ttaaaggaga tgctaccact 77520 ttagttgaag gaaatcaaac taatacagta aatggaaatc tttcttggaa agttgctggg 77580 acagttgatt gggacgttgg cggtgattgg acagaaaaaa tggcatctat gagttctatt 77640 tcatctggtc aatacacaat tgatggatcg aggattgaca ttggctaata tacttccaat 77700 gagcgctgat ttaggagaat ccatggaagg ttcttctatc gacgtcacct ttaccgctca 77760 attagaaaca ggtgaaacgt tagtatctat aaatataact agttacgaag aaactcctgg 77820 ggttttagta gaagaaagtc gcttatacgg aacatatgaa tctgtgtttg gatttggaaa 77880 tgacgcgttg aaatatcgtt taggtgatga atttaaaact gctgcttcat gggaagaact 77940 tcctactgat tctgacactc agttgtattt gtggaaagct cctcagaatc tccagaagac 78000 attcacttac gaagtaacat taatatatga ctaccaagaa caaagtgaat ctggaggttc 78060 tggcagtaat tctaggtcat cttctgatac tactgaaccg acagatcctc ctgctccagt 78120 aagaaaaact ctcgttaaaa attatactaa aactatagtt ggaaattgga gtcgttgggc 78180 taataaatta agaagctatg tgtatgagag gtcatagatg tcaggattaa gttatgataa 78240 atgtgttact gctggtcatg aagcatggcc tccaacagtt gtgaatgcta cacaaagtaa 78300 agtattcact ggaggaattg ctgttctcgt agcaggtgat ccaattacag aacatacaga 78360 cataaggaaa tgtcacagga aagaaagctg tccaaatggc tgatccaata tcatgcggtg atactgtggc 78480 tcaggcatca tctaaagtat tcattaaata ggatttaaaa tggcaaatac ccctgtaaat 78540 tatcaattaa caagaacagc aaatgctatt cccgagatat tcgtcggggg tacgtttgct 78600 gaaataaaac aaaacctcat tgaatggctt aatggccaaa atgaattttt ggattatgat 78660 tttgaaggct caagattaaa cgttctgtgc gaccttttag cttataatac attgtacatt 78720 cagcagtttg gtaatgctgc cgtgtatgaa agctttatgc gtactgctaa cttacgaagt 78780 tcagttgttc aggctgcaca agataatgga tatttaccta cttcaaaatc cgctgcacag 78840 accgaaatta tgttaacgtg tacagatgca ttgaatagaa attacattac tattcctcgc 78900 ggtactcgct ttttagcata tgcaaaggat acttctgtta atccatataa cttcgtttct 78960 accgaagacg ttattgctat tcgtgataaa aataaccaat attttccacg attaaaatta 79020 gcccagggac gtatagtaag aactgaaatc atttatgata aattaacacc tattatcatt 79080 tatgacaaaa acatagatag aaaccaagtt aaactatacg ttgatggagc agaatggatt 79140 aactggacaa gaaagtcaat ggttcatgct ggttctacat caacaattta ctacatgcgt 79200 gaaactattg atggaaacac tgaattctat tttggcgaag gtgaaatttc tgttaatgcg 79260 gcagaaggag ctctaactgc taactatatt ggaggtctta aacctaccca gaactctact 79320 attgttattg agtacatcag tactaacggt gcagatgcga acggtgcagt cggattttca 79380 tacgcagata cattaacaaa tataactgtc atcaatatta acgaaaatcc aaatgatgac 79440 ccagattttg ttggggcaga tggcggtggc gatccagaag atattgagcg tattcgcgaa 79500 ttgggtacta ttaaacgcga aacccagcaa cgctgcgtaa ctgcgaccga ctatgataca 79560 ttcgtttcag agagatttgg ttctattatt caagctgtgc agactttcac tgattctact 79620 aaacctgggt atgcatttat tgctgctaaa cctaaatcag gattgtattt aactactgtg 79680 caacgtgaag atattaaaaa ttatctcaaa gactataatt tagcgcctat tacaccgtca 79740 attatttctc ctaattatct ttttattaag actaatttaa aagtcacata tgctttaaat 79800 aaactacaag aatccgaaca gtggcttgaa ggtcaaataa ttgataaaat tgatcgctat 79860 tataccgaag atgtagaaat ttttaactca tcttttgcca agtctaagat gttaacttac 79920 gtagatgatg cagatcattc tatcattggt tcatcagcga ctattcaaat tgttcgtgaa 79980 gtacaaaact tctataaaac gcctgaagca ggtattaaat acaataatca aataaaagat 80040 cgttctatgg aatctaatac gttttcattt aattctggac gaaaggttgt aaatcctgat 80100 accggtttag aagaagatgt attatatgac gttcgtatag tatcaacaga ccgagattct 80160 aaaggaattg gtaaagttat tattggtcca tttgcttctg gcgatgttac agaaaatgaa 80220 aacattcagc cgtatacagg caacgatttt aacaaattag caaattctga tggacgcgac 80280 aaatactatg ttatcggtga aataaattat ccagctgaca tgatttattg gaatatcgct 80340 aaaattaatt taacatctga aaaatttgaa gttcagacta ttgaattata ttctgaccca 80400 accgatgatg ttatctttac tcgcgatggt tcactgattg tatttgaaaa tgacttacgt 80460 ccacaatact taactatcga tttggagcct atatcacaat gacagtaaaa gcaccttcag 80520 tcactagtct cagaatttcc aagttatccg ctaatcaggt gcaagtacgc tgggatgacg 80580 ttggtgctaa tttctactat tttgtagaaa tcgctgagac aaaatcaaac tcgggaaaaa 80640 atctcccgag taatcaatat cgttggatta atttaggata tacagcaaat aatagtttct 80700 tttttgatga tgctgatcca ttgacatcat atgttattag agtagctaca gctgcacaag 80760 attttgagca gtctgattgg atttataccg aagagtttga aacttttgct acaaatgctt 80820 atacatttca aaacatgatt gaaatgcaat tagctaataa attcattcag gaaaaattta 80880 ctcttaataa ttctaactat gttaatttta ataatgacac tataatggct gcattgatga 80940 atgaatcgtt ccaattcagc ccatcatacg ttgacgtttc atcaataagt aattttatta 81000 ttggtgaaaa tgaatatcat gaaatacaag gttctattca gcaagtatgt aaggatatta 81060 accgagttta tttgatggaa tcagaaggga ttctatatct ttttgagcgc tatcagcctg 81120 tagttaaagt atccaatgat aaaggacaaa catggaaagc tgtaaagctc ttcaatgacc 81180 gcgtaggata tcctttatct aagacggtat attaccaatc tgcaaacaca acatacgttc 81240 taggatacga taagattttc tatggccgta aatcgactga tgttagatgg tcagcagatg 81300 atgtcagatt cagttcacag gatataacat ttgctaaatt aggagaccaa cttcatttag 81360 gattcgatgt tgaaatcttc gctacttatg cgactttacc agcgaatgta tatcgtatag 81420 ctgaagccat tacttgtacg gatgattata tctatgttgt tgccagagat aaagttagat 81480 atataaaaac gagtaatgca cctatagatt ctgacccgtt atcaccaaca tactcggaaa 81540 gactttttga acctgacaca atgactataa ccggaaatcc taaagcagta tgctataaaa 81600 tggattctgt tggtgataaa gtttttgctc ttattattgg tgaagttgaa acattaaatg 81660 ctaatcctag aacttcaaaa ataattgatt ctgctgataa aggaatatat gttttaaatc 81720 atgacacaaa aacatggaaa agagtttttg gcaacactga agaagaaaga agacgtattc 81780 aaccggggta tgcgaatatg tcaactgatg gtaaattagt ttcgctatct tcgagtaatt 81840 ttaaattttt aagtgataat attgttaatg actctgaaac tgcagcaaag tatcagttaa 81900 ttggtgccgt taaatatgaa tttcctcgtg aatggttagc tgataagcat tatcatatga 81960 tggcatttat agcagatgaa aaatctgatt gggaaacttt tacgcctcag ccaataaaat 82020 actatgcaga accattcttt aactggtcta aaaaatctaa cacacgatgt tggataaaca 82080 actctgatag agctgtagtg gtttatgctg atttaaaata cactaaagtt attgaaaatt 82140 ttccagaaac atctccagac agattagttc atgaatactg ggatgacggc gattgcacta 82200 tagtaatgcc aaatgttaaa ttcactggat ttaaaaaata tgcatctggg atgctttttt 82260 ataaatcctc cggtgaaata atttcttact atgattttaa ttatcgtgtt agagatacag 82320 tagaaattat ttggaagcca actggagtat ttttaaaggc atttttacaa aaccaagaac 82380 atgaaactcc ttggtcgcct gaagaagagc gtggattagc tgaccctgat ttaagaccat 82440 taattggcac aatgatgcct gattcttatt tgttgcagga ttcgaatttt gaagcatttt 82500 gcgaagcata tattcaatat ctttctgatg gatatggaac tcagtataac aatttacgaa 82560 atttaattcg taacaaatat ccacgagaag agcatgcgtg ggagtatttg tggtcagaga 82620 tatataaaag aaacatttat ttaaatgctg acaaacgtga tgctgttgca agatttttcg 82680 aatcacgtag ctatgatttt tattctacta aaggaattga agcatcatac aaatttcttt 82740 ttaaagttct ttataatgaa gaagttgaaa ttgaaattga atctggggct ggtactgaat 82800 atgacataat cgttcaatct gattctttga ctgaagattt agtaggacaa acgatttata 82860 cagccacagg aagatgtaat gttacttata tagaaagaag ttattctaat ggtaaattgc 82920 aatggaccgt aactattcat aatcttttgg gaagattgat tgccggtcaa gaagttaaag 82980 cagaaagact tcctagtttt gaaggcgaaa ttattcgtgg ggttaaagga aaggatttgc 83040 ttcaaaataa tatagactat attaatagaa gtcgatcata ttatgtaatg aaaattaaat 83100 ccaatttacc ttcttcccgc tggaaatctg acgttattcg ttttgttcat ccagtaggat 83160 ttggatttat agcaattacc cttttaacta tgtttattaa tgttggttta actcttaaac 83220 atacagagac cataattaat aaatacaaaa actacaaatg ggattctgga ttgcctactg 83280 aatatgctga tagagtagct aaattgactc cgactggtga aattgagcat gattcggtaa 83340 caggcgaagc aatttatgaa cctggcccaa tggctggcgt agaatatcct cttcctgatg 83400 actataatac tgaaaataac aattcaatat ttcaaggtca attgccgtct gaacgacgca 83460 aattaatgag tcctctattt gatgcatctg gaacaacatt tgcacaattt agggatttag 83520 ttaataaacg tctaaaagat aatataggaa atccaagaga ccctgaaaat ccaacacagg 83580 ttaaaataga tgaatgattc aagtgttatc tatcgtgcga tagttacttc aaaatttaga 83640 acagaaaaaa tgttgaattt ttataattca attggaagtg gtccggataa aaacactatc 83700 tttatcacat ttggaagatc agaaccgtgg tcatcaaatg aaaatgaggt gggctttgct 83760 ccaccttatc caactgattc tgtattgggt gtaactgaca tgtggactca tatgatggga 83820 actgtaaagg ttcttccatc tatgcttgat gcagttattc ctcgtagaga ttggggagat 83880 actagatatc cggatccata cacatttaga attaacgata ttgtagtgtg taactcagct 83940 ccttacaatg ctactgaatc aggcgcaggc tggttagtat atcgttgttt agatgttcct 84000 gataccggaa cgtgttcaat agcatcttta actaataagg atgaatgtct taagttaggt 84060 ggaaaatgga ctccttctgt taggtcaatg actcctcctg aaggtcgagg agacgctgaa 84120 ggaacaatcg aacccggcga cggttatgtt tgggaatatc tttttgagat tccgcctgat 84180 gtatctataa atagatgcac gaatgaatat atcgtagttc cttggcctga ggaattaaaa 84240 gaagaccctg ctagatgggg gtatgaagat aatctcactt ggcaacaaga tgattttgga 84300 ttaatttacc gtgttaaggc aaatactatc cgttttaaag catatttaga ttcagtttac 84360 tttcctgatg ctgcattacc gggaaataaa ggatttagac aaatatcaat aatcaccaat 84420 cctcttgaag ctaaagttca tccaaatgac ccaaacgtta aagctgaaaa ggattattat 84480 gatccggaag atttaatgag gcattcgggc gaaatgattt atatggaaaa taggccacct 84540 attatcatgg caatggatca aacagaagaa atcaatattc tgtttacatt ttaaattaag 84600 ggagcccatg ggctcccttt ttctttataa atactataaa ctcataagga aaccgctatg 84660 ttcattcaag aaccaaagaa attgattgat accggcgaaa ttggtaacgc ttctactggt 84720 gatatcttat tcgacggtgg taataaaatt aatagtgatt ttaacgcaat ttataatgcg 84780 tttggcgatc agcgcaaaat ggcagtagca aatggcactg gagcagatgg ccaaattatt 84840 catgctactg gatattatca aaaacactct attgcagagt acgcaactcc agtaaaagtt 84900 ggcactaggc atgatattga tacctctact gtaggtgtta aagttatcat tgaaagaggc 84960 gaacttggtg actgcgttga atttattaac tcaaatggat ctatatcagt tactaatcct 85020 ttaacgattc aagcaattga ttcaattaaa ggtgtttcag gcaatttagt agtaactagc 85080 ccatatagta aagtaacttt acgctgtatt tcatctgata attctacatc ggtttggaat 85140 tattctattg aaagtatgtt tggacaaaag gaatcaccag ctgaaggtac atggaatatt 85200 tctacatccg gatcagttga tattccatta tttcatcgta ctgaatacaa tatggctaaa 85260 ttgctagtta catgccagtc agtagatgga agaaaaatta aaacagcaga aataaatatt 85320 cttgtggata ctgttaattc agaggtcatt tcttctgaat atgctgtcat gcgagttggg 85380 aatgaaaccg aagaagacga aatcgctaat attgcattta gtgttaaaga aaattatgta 85440 acggcgacta taagttcttc aactgtcggt atgagagcag cagttaaagt tatcgctacg 85500 cagaaaatcg gggtggctca ataatgaaac aaaatattaa tatcggtaat gttgtagatg 85560 atggtaccgg tgactacctg cgtaaaggtg gtataaaaat aaatgaaaac tttgatgagc 85620 tttattatga actcggtgat ggtaatgttc catattcagc cggtgcttgg aaaacttata 85680 atgcttcatc tgggcaaaca ttaaaagctg aatggggaaa atcatacgct attaatactt 85740 cgtctggaag agtaacactg caacttccta aaggaactgt taatgattat aataaagtaa 85800 ttagagctag ggatgtattt gcaacatgga atgttaatcc agttacttta gtagccgctt 85860 ctggtgatac tatcaaagga tcatcgtcat cggttgaaat taacgttcaa tttagtgatt 85920 tagagctagt ttattgcgct ccgggccgtt gggaatatgt caaaaataaa caaattgaca 85980 aaattattag ttcagacatt agcaatgtag ctcgtaaaga atttttagtc gaagttcaag 86040 gacaaacaga ctttttagat attttccgtg gaactagtta taatgttaat aacatcagag 86100 taaaacaccg cggtaatgaa ttgtattacg gcgatgtttt tagcgaaaat agcgactttg 86160 gttctcctgg agaaaatgaa ggcgaattag ttcctcttga tggatttaat attcgattaa 86220 gacagccttg taatattggt gacactgttc aaattgaaac atttatggat ggtgtatcac 86280 aatggagaag ttcatataca agacgccaaa taaaagtact ggattcaaaa ctaacatcaa 86340 agacttcttt agaaggaagt atttacgtta ctgatttatc gacgatgaaa tcaattccat 86400 tttccgcatt tggattaatt ccaggagaac ctattaatcc taattctctt gaagttcgtt 86460 ttaatggaat tttacaacaa caagctggaa cagctggata tcctctgttt ttgtgtgaag 86520 gcgctagttc agatacgcaa gaaggatgta tatctcttgg tggtgaatgg aaagaatcaa 86580 acacagatta ttctatagaa tatgaagatg gaaaacctac cagtctttta tttgatagaa 86640 aatttgaatc aggcgatata atcgttataa cgtggttcaa taatgattta ggaactcttt 86700 tagaaaaaga tgacatcatt gaattgactg atgaccgtta tgttagcaaa ggatcatcta 86760 ccgaagttac tggtgatgta gccttaacag attttgataa aatcggttgg ccaaatgttg 86820 aaaaagttga ttcttatact agaacgtata attcaatatc atctattttc gatagcattt 86880 atcctgtagg ttcaatttat gaaaatgcta taaacccaaa taatccagta acttatatgg 86940 gatttggttc atggaaatta tttggtaaag ggcaggtttt agtaggatgg aatgatgatg 87000 tcacagatcc aaactttgca ttaaacaata atgatttaga ttctagcgga aatccttcac 87060 ataccgccgg tggaacagtt ggtacaacat cagtaacgct tgaaaacgca aatcttcctg 87120 cgactaaaac tgatgaaaga gttttaattg aagacgaaaa tggatcagtt attattggag 87180 gatgtcaata tgacccagac gaaactggtc ctatatatac aaaatatcgt gaagactacg 87240 caacaacaaa ctcttcacat actcctcctg ctaatattag taatattcaa ccgtctatta 87300 ctgtataccg ttggataagg attgcataat gagtttactt aataataaag cgggagttat 87360 ttcccgctta gcagattttc ttggttttag aactaagaaa aatgatattt cggttatgaa 87420 taatcagcca gtaggtgctg taacaatttc acaaatagca aaaggttttt atgacccaaa 87480 tgtagaatct gctatcaatg atgttagaaa tatggcagag caacaggttg gagctgtatt 87540 agttaatata agtggcgtat ctcctactgg cgtgcagcaa acagactatt ggtcatttga 87600 aggaactgtt actgatactt cagccaaacc aggtgacaca gttattgtta atatgtttgg 87660 cattcctgtt aaagctacta atggaatgac ttcaatcgaa tttaccagtg ccgttagaac 87720 agctctgcag gaaatggttg caaaatttat tgcaattgat tcatttgaag accatcctac 87780 cataggaaat aaaatacaag ttaagtattt agataaccaa gaacatatct tagaacaata 87840 ctctgataaa ggaattactt tcaaacaaga aataatttct ccttctaaac ctggatacgg 87900 aacttggcaa ttattaggtg cgcaaactgt cacgctagat agtcacacac aacctacggt 87960 attttattat tttgagagaa tagcatgagt aacaatacat atcagcacgt atcaaatgaa 88020 tcaaaatatg ttaaattcga tccagtagga tcgaattttc ctgacactgt cacgacagtg 88080 cagtctgcat tatcaaaaat aagtaatatc ggcgtaaatg gtattcctga tgcaactatg 88140 gaagttaaag gaatagcaat gattgcgtca gagcaagagg ttttagatgg aactaataat 88200 tctaaaatcg ttacaccagc tacattagca acaagattat tgtatccaaa tgctactgaa 88260 actaagtatg gtttaacgcg ctattcaaca aatgaagaaa cattagaagg ctcagataat 88320 aattaccaa taacgccgca aaaactgaaa taccatactg acgatgtgtt ccaaaataga 88380 tattcgtctg agtcatcaaa cggggttatt aaaatatcat ctacacctgc agctttagct 88440 ggagttgatg atactacggc aatgactcca ttaaaaacgc aaaaacttgc aataaaatta 88500 atttcacaaa tagctccttc cgaagatact gcatcagaat ctgtgagagg tgtagttcaa 88560 ttatctactg ttgcgcaaac tcgtcaagga actctccgcg aaggatatgc aatttctccg 88620 tataccttta tgaattctgt tgcaacacaa gaatataagg gtgttatacg tttaggaaca 88680 caatcggaaa ttaacagtaa tttgggagat gttgcagtaa cgggtgaaac gctaaatggt 88740 cgaggagcta ctggttctat gcgtggagta gttaaattaa cgacgcaagc cggtattgcc 88800 cctgaaggtg atagctctgg tgcattagca tggaacgcag atgtaattaa tactcgtggt 88860 ggacaaacta ttaatggttc tttaaattta gaccatctta cagcaaacgg aatttggtcg 88920 cgcggcggaa tgtggaaaaa tggcgatcaa cctgttgcca ctgaaagata cgcgtccgaa 88980 agggttccag ttggaactat tatgatgttt gctggagatt cagcacctcc gggttggatt 89040 atgtgccacg gcggaaccgt gtcaggagat caatatcctg attatagaaa cacagttgga 89100 acgagatttg gtggcgattg gaataatcct ggcattcctg atatgcgagg tctttttgtt 89160 agaggagcgg gcaccggcgg tcatatttta aatcaacgag gacaagatgg ttatgggaag 89220 gatagacttg gtgtaggatg tgatggaatg catgttggtg gtgttcaagc acaacaaata 89280 tcataccata aacatgctgg tgcctggggg gaaaatggaa ataacagagg ttatgcaccg 89340 tttggcgcat ctaatggcaa tggatatttg ggcaatggta aaagcgccga ctgggacaac 89400 catttgttct ttactaatga cggatttgaa atgggtggtc ctcgtgactc gtttggcacg 89460 ttaaatcgcg aaggattaat tggttatgaa actagaccat ggaatatatc attaaactat 89520 attattaaaa ttcattacta aggattacaa atgattgaat taaaagagtt accttttgtt 89580 gatagcgttc ctggcgaagg tcaggaacgt atttcatgga ttaaaaatgg tgaagaaata 89640 ctaggagcta gtactaagta tggaaacgat ggatcaatga atagaccaac tgtttccgtg 89700 tttaaaaacg tcgaagttct tgatgaaaat gtgggaattc ttaaaactgc tgttgaaaca 89760 tcacaggaag atattaaaac aattcaaggc attttagatg tatcaggaga tatagaagcg 89820 ctatcacaaa tcagcgttaa taaaaatgac atatcaaatt taaaaacgct tacgagtgaa 89880 catactgata tattaaatgg tacaaatact acggttgata atattctttc tgatattggt 89940 ccatttaatt cgcaagcaaa ttcagtttat agaacgatta gaaatgattt gttatggatt 90000 aaaagggaat taggacaata tgctgggcaa gatattaatg gtcttcctgt tgtaggaaat 90060 agcagcacgg ggatgaagca ccgtatcatt aataatacag atgctataac ttcccaagga 90120 atacgtctaa gtgatttgga agaaaaattt attgaatctg atgtaggttc actgacaatt 90180 gaagtcggaa atcttagaca agaacttgga caaagaccat cttcatttag tgaaagcata 90240 tattcacgtg tgcataattt agatcaatca cagattaatc ttagttccga aattaaatct 90300 atcaaaactt ctattggata tccaggaaat acttcaataa tcacagatgt caatgtcaac 90360 agtcaagaaa tttcagcttt aaatgatgaa ctaaataaaa gtggcggcgt taaacagcga 90420 ttaactgtta ttgaaacatc gattggttca gatgatattc cttctagtat taaaggtcaa 90480 attaaagata ataccacttc tattgaatct ttaaatggaa ttgtaggtga aaacacctcg 90540 tccggtttaa gagctaacgt ttcatggcta aatcagatag ttggaactga ttctagcgga 90600 ggtcaacctt ctcctccggg gtctctttta aatagagttt caactgttga aacctctgtt 90660 aatagactta acaatgatgt tcaaaactta caggttgaaa ttggtaataa cagttccgga 90720 attaaagggc aagttgtaac actaaataaa ttagtaagtg gaacaaatcc gaatggttca 90780 actgtcgaag aacgcggatt gactaattca ataaaagcta atgagactaa catttcttca 90840 attaatcaag agattcgtag tattaaaggt aatgtgtcct cattgcagag ggatgtccag 90900 actttacaag aagctggtta tattcctgaa gctccaaaag atggtcaagc ttacgttcgt 90960 aaagacggcg aatgggtatt gctttctacc tttttatcac cagcataaca tggggccgca 91020 aggccctaaa ggattttaaa tgtcaggata taattctcag aatccaaagg aactcaaaga 91080 tgtcattcta agacgtttag gggctccaat tattaatgtt gagttaacac ccgatcaaat 91140 ttatgattgt atccagcgtg ccctagaatt atacggtgaa taccattttg atggacttaa 91200 caaaggtttt catgtatttt atgtaggaga tgatgaagaa aagtataaga ctggagtatt 91260 tgatttaaga ggttctaacg tatttgcagt aactcgcatt ttgcgcacga atattggatc 91320 aataacgtca atggacggaa acgctacata tccatggttt actgactttc ttttaggaat 91380 ggctggtatt aatggtggca tgggaacttc ttgtaataga ttttatggac caaatgcctt 91440 tggagctgat ttaggatatt ttacccagct taccagttac atgggaatga tgcaagatat 91500 gctttcgcct attccagact tttggtttaa ttcagcaaat gaacaactca aagtcatggg 91560 aaacttccaa aaatatgatt tgattatcgt agaaagctgg actaaatcat acattgatac 91620 aaacaaaatg gttggaaata cagtaggata tggaacagtc ggtccacaag atagctggtc 91680 attatctgaa cgatataata atccagaccg caatttagta ggccgtgttg ttggtcaaga 91740 tccagatgtt aagcaaggtg cttataataa tcgttgggtg aaagactatg caacagcttt 91800 agctaaagaa ttgaatggtc aaattttagc acgtcaccaa ggaatgatgc ttcccggcgg 91860 cgttacaatt gatggtcaac gtttaataga agaagctcgt ttagaaaaag aagcactgcg 91920 cgaagaatta tacttacttg accctccatt tggaattttt gtaggttaat atggctactt 91980 acgataaaaa tctctttgct aaattggaaa accgcacagg ttattctcag accaatgaaa 92040 cagaaatact aaatccttat gtaaatttta accactatca aaacagccaa atactagctg 92100 atgtattagt agctgaaagc attcaaatgc gaggtgtaga atgctattat gttccaagag 92160 agtatgtttc ccctgatttg gtattcggcg aagacctaaa aaataaattt actaaagcat 92220 ggaaatttgc tgcatattta aattcatttg aaggatatga aggagctaaa tcgttctttg 92280 gtaactttgg tatgcaagta caggatgaag taactttgtc cattaatcca aacctgttta 92340 aacatcaagt aaatggaaaa gaacccaagg aaggtgattt gatatatttt cctatggata 92400 acagcttatt tgaaatcaac tgggttgaac catatgaccc attttatcaa ttaggccaaa 92460 acgctattcg taaaattaca gcaggtaaat tcatttattc tggagaagaa attaatccgg 92520 ttctacagaa aaatgaagga attaacattc cagaattcag tgaattagaa ttaaatcctg 92580 ttcgtaatct taatggcatt catgatatta atattgatca gtatgctgaa gtagatcaaa 92640 ttaattctga agctaaagaa tatgttgaac cttatgttgt tgtcaataac agaggaaaat 92700 ctttcgaatc tagcccattt gataatgatt tcatggatta ataaatacta taaattaatt 92760 aaagcccaga ttaggagaaa tcatgtttgg ttatttttat aattcgtctt ttagacgata 92820 tgctaccttg atgggcgatt tgttttcaaa tatccaaatc aaacgtcagt tagaatctgg 92880 tgataagttt atacgtgttc ctattacgta tgcatcaaag gaacacttca tgatgaaatt 92940 aaataaatgg acatcgataa attcgcaaga agatgtagct aaagttgaaa ctattctacc 93000 tcgtataaat ttacatttag ttgattttag ctataatgct ccatttaaaa caaacatttt 93060 aaatcagaat ttactgcaaa aaggcgcaac ttctgtagta tcacagtata atccatctcc 93120 tattaaaatg atttatgaat tgagtatctt tactcgatac gaagacgata tgtttcaaat 93180 agttgaacag attcttccat attttcaacc tcattttaat acaactatgt acgaacagtt 93240 tggaaatgat attccattta aaagggatat taaaattgta ctgatgtctg ctgctataga 93300 tgaagctata gatggagata atttatctcg tcgtagaatt gaatggtcac taacatttga 93360 agtaaatggg tggatgtatc ctccagtaga tgatgcagaa ggattaattc gtactactta 93420 tacagatttt cacgccaata caagagattt gcctgatggc gaaggtgttt ttgaatctgt 93480 cgatagcgaa gttgttcctc gagatattaa cccagaagac tgggatggaa cagtaaaaca 93540 aactttcacc agcaatgtaa atagaccaac accgccagaa cctcctggcc caagaacata 93600 gaggttatta tggaaggtct tgatataaac aaacttttag atatttctga cctccccgga 93660 attgacgggg aggaaattaa agtatatgaa cctctgcaat tagtagaagt taaaagcaat 93720 cctcaaaacc gtactcctga cttagaagat gattatggag tagttcgtcg aaatatgcat 93780 tttcaacaac aaatgctaat ggacgcagcc aagatttttc ttgagacggc aaagaatgct 93840 gattctcctc gtcacatgga agtatttgca actcttatgg ggcaaatgac tacgacgaac 93900 agagaaatac tgaagcttca caaagatatg aaagatatta catctgaaca ggttggcacc 93960 aaaggcgctg ttcctacagg tcaaatgaat attcagaatg cgacagtatt catgggttca 94020 ccaacagaat taatggacga aattggtgat gcttacgagg ctcaagaagc tcgtgagaag 94080 gtgataaatg gaacaaccga ttaatgcatt aaatgatttc caccctttaa atgaagctgg 94140 aaaaatttta ataaaacacc caagcttagc agaaagaaaa gatgaagatg gaattcattg 94200 gataaaatca cagtgggatg gaaaatggta tcctgaaaaa ttcagcgatt atcttcgttt 94260 acacaaaata gtaaaaatcc caaataattc tgataagcct gaattatttc aaacttataa 94320 agataagaat aataaaagat ctcggtatat gggtcttcct aacttaaaac gagctaatat 94380 taaaacacaa tggactcgtg aaatggttga ggaatggaaa aaatgccgag acgatattgt 94440 ttattttgcg gaaacatact gcgctattac tcatattgac tatggtgtca taaaggttca 94500 attacgtgac taccaacgtg atatgctcaa aataatgtca tctaaacgta tgactgtttg 94560 taatttatca cgtcagcttg gtaaaacaac tgtagtagct atttttcttg cacactttgt 94620 atgctttaac aaggataaag ctgtaggtat tcttgcgcac aaaggctcaa tgtctgcaga 94680 agttttagat cgtactaagc aagcaattga actgcttcct gactttttac aacccggaat 94740 tgttgaatgg aataaagggt ctattgaact tgataatggt tcctcaatcg gagcctatgc 94800 ttcctctcct gacgcagttc gtggtaactc gttcgcaatg atttatattg acgaatgcgc 94860 gtttattcca aacttccatg attcctggct tgctattcaa ccggtaattt catctggtcg 94920 tcgttcgaaa attattatta ctacgactcc taatggatta aatcattttt atgatatttg 94980 gactgctgct gttgaaggta aatcagggtt tgaaccatac actgctattt ggaattcagt 95040 taaagagcgt ctttataacg atgaagatat ttttgacgat ggatggcaat ggagcataca 95100 aaccattaat ggttctactt tagctcaatt tcgtcaagaa cacaccgcag cgtttgaagg 95160 gacttctggt acattaattt caggaatgaa attagctgtt atggatttca tcgaagtaac 95220 accagatgat cacggttttc atcgatttaa aagctctgaa ccagatagaa aatatattgc 95280 aactttagac tgctcagaag gtcgtggaca agattatcat gctttacata ttattgatgt 95340 cacagatgat gtgtgggaac aagttggggt tttacattca aacacaattt ctcatttaat 95400 tctacctgac atcgttatgc gttatttagt agaatataat gaatgcccag tttatattga 95460 attaaatagt actggtgtgt cagttgcgaa atcgctttat atggatttag aatacgaagg 95520 cgttatttgc gattcatata ctgatttagg aatgaagcaa actaaacgaa cgaaagcagt 95580 aggatgctct acattaaaag accttattga aaaagataag cttattattc atcaccgcgc 95640 aactattcag gagtttagaa cgtttagtga aaaaggcgtg tcttgggcgg ctgaagaagg 95700 ttatcatgat gatttagtaa tgtctttagt gatttttgga tggttatcaa cacaatcaaa 95760 atttattgat tatgctgaca aagatgacat gcgattagca tctgaagtgt tttcaaaaga 95820 acttcaagat atgggtgatg aatacgctcc agttatattt gttgattcgg ttcattctgc 95880 tgagtatgtt ccagtatctc atggtatgtc aatggtataa atatattaaa gcatattaaa 95940 gaggattaaa aatgacttta ttatctccgg gcattgagct caaagaaact acggttcaaa 96000 gcaccgtggt taataactct actggtacag cagctttggc cggtaaattc cagtggggtc 96060 ctgcttttca gatcaaacag gttacaaatg aagtagattt agttaatact tttggtcaac 96120 ctacagctga aactgctgat tattttatgt ctgcaatgaa tttcttacaa tatggaaatg 96180 atttgcgagt tgtgcgtgct gtcgatagag ataccgctaa aaactcatct ccgattgccg 96240 gtaatattga atacactatt tctaccccag gtagtaacta cgcggttgga gataaaatca 96300 cggttaagta tgtttcagaa gatgttgaaa cagaatgtaa agttaccgaa gtagatgctg 96360 atggaaaaat taagaaaatt aatattccta ccgcaaaaat tatcgctaaa gcgaaagaag 96420 taggcgaata tccagcatta ggttctaact ggaccgcgga aatttcttcg tcttcctctg 96480 gtttagctgc agtaataact cttggaaaaa ttattactga ttctggtatt ttattagctg 96540 aaattgaaaa tgctgaagct gctatgacag ctgttgactt tcaagcaaat ctcgaaaaat 96600 atggaattcc aggagtagta gctctttatc caggcgagtt gggcgataaa atcgaaattg 96660 aaatcgtatc taaagctgac tacgcaaaag gtgcttctgc attacttcca atttatccag 96720 gtggcggaac acgcgcatct actgccaaag cagtgtttgg atatggacca caaactgatt 96780 cacaatacgc tattatagtt cgtcgcaatg atgctattgt tcaaagcgtt gttctttcga 96840 caaagcgagg tgaaaaagat atttacgata gtaacatcta tattgacgac tttttcgcaa 96900 aaggtggttc agaatatatt ttcgcaactg cacaaaactg gccagaaggc ttctctggaa 96960 ttttaactct gtctggtgga ttatcatcaa atgctgaagt aacagcagga gatttgatgg 97020 aagcttgggg cttctttgct gaccgtgaat ctgttgatgt tcagttgttt attgcgggtt 97080 cttgtgccgg tgaatcttta gaaacagcat ctactgtcca aaaacacgtc gtttcaattg 97140 gggatgctcg ccaagattgc ttagtactgt gctcgccacc gcgtgaaact gtagttggaa 97200 ttcctgtaac tcgtgctgtt gataacttag tcaattggag aactgccgca ggttcatata 97260 ctgataataa ctttaatatt agttcaacct acgcagcaat tgatggtaac tacaagtatc 97320 agtatgacaa atataatgat gtaaatcgtt gggttccatt agcagctgat attgccggat 97380 tgtgcgcaag aactgacaac gtatctcaga cttggatgtc tccagctggt tataatcgtg 97440 gccagattct taacgttatt aaacttgcta ttgaaactcg ccaggctcag cgcgaccgtt 97500 tataccaaga agctatcaac ccggtaactg gtacaggtgg tgatggttac gtattatatg 97560 gtgataaaac agctacttct gttccttctc catttgatcg tattaacgtt cgtcgtctgt 97620 ttaatatgtt gaaaacgaat atcggacgta gttcaaaata tcgtttgttc gaattaaaca 97680 acgcgtttac tcgttcatca ttccgcacag aaactgccca gtacttacag ggaattaaag 97740 ctctcggtgg aatttatgaa tatcgtgtag tttgcgatac aacaaataac actccgtcag 97800 taattgatag aaatgagttt gttgcaacat tctacattca accggcgcgc agtataaatt 97860 atattacttt gaatttcgtc gcaactgcta ctggtgcaga tttcgatgag ttaactggtc 97920 ttgcaggtta atacggtgca ttctaaaggc ctgtttcggc aggccatata aatacactat 97980 atccttaatt ctttaattct atatgcccta ggttaaacat agggatataa atactacaga 98040 ggctaatatg tttgtagatg atgtaacacg agcgtttgaa tctggtgatt ttgctcgacc 98100 taacttattc caagtagaaa tttcttatct tggacaaaat tttacgtttc aatgcaaagc 98160 cactgcttta ccagctggta ttgtagaaaa aattccagtc ggatttatga accgtaaaat 98220 taacgtagca ggcgatcgta cattcgatga ctggactgtt acagtaatga acgatgaggc 98280 acatgatgct cgccagaagt ttgttgattg gcaaagcatt gctgctgggc aagggaacga 98340 aattactggt ggaaaaccag cagagtataa aaagagcgct gttgttcgcc aatacgctcg 98400 tgatgctaaa acagtaacaa aagaaattga aattaaaggt ctatggccta ctaacgttgg 98460 tgaacttcaa ttagattggg attcaaacaa tgaaatccaa acatttgaag taactcttgc 98520 tctcgattat tgggaataaa atgaatgggg agaaatcccc atcctgcttt aagcagagaa 98580 gtccattata aatataacta taattcccat ttggagaata caatgaaatt taatgtatta 98640 agtttgtttg ctccatgggc taaaatggac gaacgaaatt ttaaagacca agaaaaagaa 98700 gatcttgttt ccattacagc cccaaagctt gatgatggag caagagaatt tgaagtaagc 98760 tcgaatgaag ctgcttctcc ttataatgct gcattccaaa caatttttgg ttcatatgaa 98820 ccgggaatga aaaccactcg tgagcttatt gatacatatc gtaatctcat gaataactat 98880 gaagtagata atgcagtttc agaaatcgtt tcagatgcta tcgtctacga agatgatact 98940 gaagtcgtag cgttaaattt ggataaatct aaatttagcc caaaaattaa aaatatgatg 99000 ttagatgaat ttagtgatgt attaaatcat ctatcgtttc aacgaaaagg ttctgatcat 99060 tttagacgtt ggtatgtcga ttcaagaatt ttcttccata aaatcattga tccaaaacgt 99120 ccaaaagaag gcataaaaga attacgtaga ttagaccctc gccaagttca gtatgttcgt 99180 gaaattataa ccgaaactga agctggcaca aaaatagtta aaggttacaa agagtatttt 99240 atatatgata ctgcccatga gtcatatgcg tgtgatggta gaatgtatga agctggcaca 99300 aaaataaaaa ttcctaaagc tgctgtcgtt tatgcccatt ctggattagt cgattgttgt 99360 ggtaaaaata tcatcgggta tttacatcgt gctgttaaac ctgctaacca attaaaatta 99420 ttagaagatg ctgtagtcat ttatcgcatt actcgtgctc ctgaccgtcg tgtttggtat 99480 gtagacacag gtaatatgcc tgctcgtaaa gctgccgagc acatgcaaca tgtcatgaac 99540 acgatgaaaa accgtgtagt atatgacgca tcgaccggta aaataaaaaa tcaacagcat 99600 aatatgtcta tgaccgaaga ctattggtta cagcgccgcg atggtaaagc tgtgacagaa 99660 gttgatactc ttcctggtgc cgataatact ggtaatatgg aagatgttcg ttggtttaga 99720 caagctcttt atatggcatt acgtgttcct ctttcacgca tcccgcaaga ccaacaaggc 99780 ggtgtgatgt ttgattctgg aactagcatt acacgtgatg aattaacgtt tgctaaattt 99840 attcgtgagt tacagcataa gtttgaagaa gttttcctgg atccgcttaa aacaaatctg 99900 ttgcttaaag gtataatcac agaagatgag tggaatgatg aaataaataa tattaagata 99960 gaatttcatc gggatagcta ctttactgaa ctcaaagaag cagaaatttt ggaacgaaga 100020 attaatatgc taaccatggc agaaccattt attggtaaat atatttctca cagaactgct 100080 atgaaagata ttttgcagat gactgatgaa gaaatagaac aagaagccaa gcaaattgaa 100140 gaagagtcta aagaggctcg tttccaagac cccgaccaag aacaagagga tttttaatgg 100200 aaggtttaat tgaagctatt aaatcaaacg acctcgtagc cgctcgtaaa ttctttgctg 100260 aagccatggc tgcaagaacg attgatttaa ttaaagaaga aaaaatcgct atcgctcgta 100320 atttcttaat cgaaggtgaa gaacctgatg atgaggatga cgaagacgag gatgatgacg 100380 aagatagcga tgataaagac gacaaaaaag gcaaagactc tgacgaagat gacgaagacg 100440 aggatgatga ataatgcttc tgatccctga aactcatgaa ttagttctcg agaatgtcga 100500 agcacttatt cctgaagcac agggtcgctt tgacgaattg tcttctgctt taaataaaga 100560 cgatataaat acaattgtcg agaatatgct tgatgatgaa actgatttag cgattgcatt 100620 agcttctatt aatgaagata tgccgctaaa tgaattcatc gttaaacatg tttctgctcg 100680 tggtgaaatt acacgtacta aagaccgcaa gacgcgtgaa cgtaatgcat ttcaaaccac 100740 cgggctgtct aaagcaaaac gtagacaaat tgctcgcaaa gctaccaaaa cgaagattgc 100800 caacccagca ggtcaatctc gtgctcagcg taagcgtaaa aaagctctta aacgccgtaa 100860 agcattagga ttaagctaat gaatgaaccc caattactaa ttgaaacttg gggtcaacct 100920 ggcgaaatta ttgatggcgt gccaatgctt gaatcccatg atggaaaaga cttaggttta 100980 aaacctggtt tatacatcga aggaatattc atgcaagcag aagtcgtcaa tagaaataaa 101040 cgtctttatc caaaacgtat attagaaaaa gcggtaaaag actatattaa tgagcaagtt 101100 ttaactaaac aagctctcgg agaattaaat catcctccac gcgctaatgt tgacccgatg 101160 caagccgcta tcattataga agatatgtgg tggaaaggaa atgacgtata cggacgagct 101220 cgtgttattg aaggtgacca tggtcctgga gataaattag cagctaatat tcgtgccgga 101280 tggattccag gagtttcttc tcgtggatta ggttcattga ctgacacaaa taaaggttat 101340 cgtatcgtaa acgaaggatt caaattaact gtaggtgttg atgcagtatg gggtccaagt 101400 gctccagatg catgggtaac tcctaaggaa attaccgaat cacagacggc ggaagccgat 101460 acaagtgccg atgacgccta tatggctctc gcagaggcca tgaaaaaagc gttataaata 101520 ttattatcta aacaacagga ctacaaaatg cttaaagaac aactgattgc tgaagcgcaa 101580 aaaattgatg cttccgttgc tcttgatagt attttcgaat cagttaatat ttctccggaa 101640 gcaaaagaaa ctttcggcac tgtattcgaa gctaccgtca agcagcacgc cgttaaatta 101700 gctgaatctc atatcgctaa aattgctgaa aaagcagaag aagaagtaga aaaaaataaa 101760 gaagaagccg aagaaaaagc tgagaagaaa attgctgagc aagcttctaa attcatcgac 101820 catcttgcaa aagaatggct cgctgaaaat aaattagcag ttgataaagg catcaaagcc 101880 gaactgtttg aatccatgct aggtggatta aaagagctct ttgttgaaca caacgtcgtt 101940 gttccagaag aatcagttga tgttgtagct gaaatggaag aagagctgca agaacataaa 102000 gaagaatcag ctcgtctgtt cgaagaactc aatatgcgcg acgcatatat caattatgtg 102060 cagcgtgaag tggcattgag cgaaagtact aaagatctga ctgagtctca aaaagaaaaa 102120 gtctctgctc tggtcgaagg tatggattat tcagatgcat tctcaagtaa attgagtgcc 102180 atcgtagaaa tggtgaagaa gtctaataaa gatgaaagca ctattactga gggataaat 102240 actcctgata ctgaagcagc cggactgaat ttcgtcactg aagctgtaga agataaaact 102300 gcacctggtg cagaagatat tgtaagtgta tatgcgaaag tcgcatctcg tttctaattt 102360 taaaggttaa cacaaatgac tatcaaaact aaagctgaac ttttgaacaa atggaagcca 102420 ttactggaag gtgaaggttt accggaaatt gctaatagca aacaagcgat tatcgctaaa 102480 atctttgaaa accaggaaaa agatttccag acagctccag agtacaaaga cgaaaaaatc 102540 gctcaggcgt tcggttcttt cttaacagaa gctgaaatcg gtggtgacca cggttacaac 102600 gctactaaca tcgctgctgg tcagacttct ggcgcagtaa ctcagattgg cccagctgtt 102660 atgggtatgg tacgtcgtgc tattcctaac ctgattgctt tcgatatttg tggtgttcag 102720 ccgatgaaca gcccgactgg ccaggtattc gcactgcgtg cagtatatgg taaagaccca 102780 atcgctgccg gtgctaaaga agcattccac ccaatgtatg gtccagatgc aatgttctct 102840 ggtcagggtg ctgctaagaa attcccagct ctggctgcta gcacacaaac cacagtaggt 102900 gatatctata ctcacttctt ccaggacact ggtactgtgt atctgcaggc ttctgctcaa 102960 gtaacaatta gttctactgc agatgatgca gctaaattag atgctgaaat taagaaacaa 103020 atggaagctg gcgtactggt agaaattgct gaaggtatgg ctacttctat cgctgaactc 103080 caggaaggtt tcaacggttc taccgataac ccatggaatg aaatgggctt ccgtatcgat 103140 aaacaagtta tcgaagctaa atctcgccag ctgaaagctg cttactctat cgaattagca 103200 caagacctcc gcgctgttca cggtatggat gctgatgctg aactgtctgg tattctggct 103260 accgaaatca tgttggaaat caaccgtgaa gttgttgatt ggattaacta ctcagctcag 103320 gttggtaaat ctggtatgac cctgactcct ggttctaaag ctggtgtatt tgacttccag 103380 gatccgattg atattcgtgg tgctcgctgg gcgggtgaat cctttaaagc tctgttgttc 103440 cagattgaca aagaagcagt tgaaattgct cgtcagaccg gtcgtggtga aggtaacttc 103500 attatcgctt cccgtaacgt agttaacgtt ctggcttcag ttgatactgg catttcttat 103560 gctgcacagg gtctggctac cggctttaac actgatacta ccaagtcagt atttgctggt 103620 gttctgggtg gtaaataccg tgtatatatc gaccagtatg ctaaacagga ttatttcact 103680 gtaggttata aaggtccgaa cgaaatggat gctggtattt actatgctcc atatgtagct 103740 ctgactccgc tgcgtggttc cgatccgaag aacttccaac cagtaatggg attcaaaact 103800 cgttacggta tcggtatcaa cccatttgca gaatccgctg ctcaggctcc ggcttctcgc 103860 atccagagcg gtatgccttc tattctgaat agccttggta aaaacgctta cttccgccgt 103920 gtatatgtta aaggtatcta atctttgacg atttaaggga ccttcgggtc cctttagttg 103980 tttttatggt ataaataaat catataaacc aaaaggaaag cgcaatggct aaaatcaacg 104040 aacttctgcg cgaatcaacc acaacgaata gcaactcaat cggtcgccca aatctcgttg 104100 ctttgactcg cgctaccact aaattaatat attctgacat tgtagcaacg caaagaacta 104160 atcaacctgt tgctgctttt tatggtatca aataccttaa cccagacaac gaatttacat 104220 ttaaaactgg tgctacttac gctggcgaag ctggatatgt agaccgagaa caaatcacag 104280 aattaacaga agagtctaaa ttaactctca ataaaggcga tttattcaaa tataataata 104340 tcgtttataa agtattagaa gatactccat tcgctgatat tgaagaaagc gacttagagt 104400 tagctcttca gattgcaatt gttcttttaa aggttcgtct attttctgac gcagcgtcaa 104460 caagcaaatt tgaaagctct gatagtgaaa ttgcggatgc tagatttcag attaataaat 104520 ggcaaaccgc ggttaaatct cgtaaactta aaactggcat cacagttgaa ttagcgcaag 104580 atttagaagc aaatggattc gatgctccta atttcttgga agatttgctt gcaactgaaa 104640 tggcagatga aatcaataaa gatattctgc agtctttgat tacagtgtca aaacgctata 104700 aagttacagg aattactgat agtggattca tcgatttgag ttatgcatct gcacctgaag 104760 cgggtcgttc attatatcga atggtatgtg aaatggtttc gcatatccaa aaagaatcaa 104820 cttatacagc aacgttctgt gttgcttcag ctcgtgccgc tgcgattctt gctgcatcag 104880 gttggttaaa acataaacca gaagatgata aatatctttc acaaaatgcc tacgggttct 104940 tagctaatgg tttaccgctt tattgcgata ctaacagccc attagattat gtaatcgttg 105000 gtgtagtaga aaatatcggt gaaaaagaaa ttgttgggtc aattttctat gctccgtata 105060 cagaaggtct tgacttagat gaccctgaac atgtaggtgc atttaaagtt gtagttgatc 105120 cgaaagttt gcagccatct atcggtttat tagttagata tgctttatct gcaaatcctt 105180 acactgtagc aaaagatgaa aaagaagcaa gagtaattga cggtggagac atggataaaa 105240 tggcgggtcg ttcagatttg tctgttttat taggtgttaa gctaccaaaa attatcattg 105300 atgaataaaa caaagggacc gaaaggtccc tttttattta acttaccaat tcaatccaag 105360 ccggacgaag tacatcttgt accattttaa ctaattcctt cttaatcaaa gaaggattat 105420 ccgcttgagt tagagtaata ccttcacgag aagtttcttc caaaatatct tgaaccgtta 105480 gtcccatcac ctttccaaaa tcctttggac caatttcgcc aattttagaa ataacgttat 105540 ttacgcggtt tagtgtaacg taacaagcta aaattccaac caatttgtta tcagcttctg 105600 atagttcaac tttagcttta ataggcttat cagacttttt cttttcacta aatttagagt 105660 tcttgcattt aatcgctaca cgagcaccgt ttggcagcca tttagggaaa caaggcttca 105720 gaacataacc ttctgcagta ttatcaccaa taacattagc atcaaataca caattatttg 105780 cttcgacaag gtcttccgat gccgtaacgt tataagcggc taagacggaa tcaaggtcgt 105840 ttggaatcat gataagagca tcaaatgttc cacgtccaag cattggtgcc attttaaaac 105900 caaacgtatt acagaaatct tgcatttcgt aatcactcat gtaataagta tcaccgcttt 105960 ccgtgtttat gatgatatcg aatacataga aatctttttc accgtagtca acacctttct 106020 gaattccacc accagcgaat tcaccaaaga cttgatatgt caccggcact gaagttgaaa 106080 tactgtccat gacttcttga acgcctttaa tagctttatc atactttttg agtactattt 106140 catagccata aaaatcttct gctggaagaa taggaccagt acgtttagcg caagttactt 106200 tatcacgctc aataatcaat gagaaatttg taccatgaat cttttcacga gctacccact 106260 ccccaccagt caatcccaag ctataaagtt tttcaatgaa tttagaattg taatgatttt 106320 caagactgct atacttttta aacataatta atcctcaaaa tgtaatttct aaccaatcac 106380 catcacgctg atcactattg actttaaagc taaatccttc ttttctcagc caatcaccaa 106440 tttcttcagt aatcaattta tcgcgagcag tacaataata actaaaatat gttttacctt 106500 gttcagctgc tttattagca agttccgaaa aatctttaat aaaacactct aacttaaact 106560 gtttactttt aagtgctttt tcacgtaatt gattagcaaa agattcattt tcataaagat 106620 catactgttc catttttcac ctttttatta atatgccttt ttctatagac aactttttct 106680 cgagtttcaa atttattctt agcagtcata gctcgagccc ataatacagc cacttccttt 106740 gcctgtaagt tcaattcacg agcaatttca atgaatgact ttccagactc atgaagagta 106800 aacaccacaa cctcagttct cataatcaat ctcatgttat cgagttggtg ccattatata 106860 catcattttc tgagtgtgtt ttgtgtgctt tcaaaatgaa gaaaggggcc gaagcccctt 106920 atgattatgg ataggatatag atgataccag tttctaaagc agttttatga atgatgtatc 106980 cattacgtga ttcttgaaca tcaacttctg gatagtcttt catcatcttc tgaagggtgt 107040 aacgatgcag gtagtattta ctatctggat cttcagtttt ccaatcttta ccttcttcgg 107100 tcattttttg gatttcatcc ataacccacc aaccgcacca gatataagcc gaagtacgat 107160 gtggaagagg atgaacataa ggcaattcac cttctggttc tggagcaact ttatcagtta 107220 cctgaacttg accttctgct gtgatagttt tgctatcata atcagtagca gtaacagttg 107280 cagtaacttc aatagtttga cttccaatag atgatgtatc aacggtgtat acattagttg 107340 acccttctac tggagaagaa tctttcttcc atgaatattc gatttgcgct tcttctggag 107400 catcagtgac attagcagta aatgtagccg aagcatcttg ctgaacgtta atagaaggag 107460 gagtcaatgt aacctgtgga ttcattgttt tcttattaac agtcaatgat acttcattag 107520 aagtaactgt ttttgcgtca taatctgttg ctgttacttg cgctacgcat ttaattcttt 107580 ttactccact tgtagttgga gtatagctaa atgtagcaga agtcgcttca ccaatttgag 107640 aatcatctac ataccattga tatgtagcag acgctccatc gggttgagaa gctaaggcag 107700 cagtaaattg aactggggtt ccaattactc cagcagcggg actattggga gttactgcca 107760 atgtagttgt ctgagttttg tttttgactg tgatagttgt agtagcttct gctatttcag 107820 cttcagattc tggaactgta tttgttgcaa caactttaat agtcttttga ccagcaggac 107880 cttttaatac ataatcaaaa gttgccgctg atccttcttg cggagcatta tctacactcc 107940 aagcataggt aatagttcca cctccagttt caccactggg tgcagcagta aactgcttag 108000 tttcatcaat aactccagta ggtgttttag gagttatatc aactgtaaaa gccataagtt 108060 atccttattt taatgttacg aaagaagaat tgcgtgtttc acgaattaga actgatccgt 108120 cgcgattaat gtaataaatt aagctaaata aagtttggtg cgccgacgcg tgttcaaaac 108180 tagttgggtg agatttccaa tccggagttt cagcaatcca ctggtaaatc caccaaggaa 108240 cggtacagaa tcctggattt tttccaatca gttgaagatt cggactaaag ttttccggaa 108300 gagtaaatac agacggcttt tcagattcaa taatcttatc tacagcttgt tcaaactttt 108360 cttcaacaaa aggagtatct tcaatcaaaa catcggtatt ttcaggaatt ttatccgttt 108420 ctactacttc aattttaatg tcagatttaa ccggagaatc aatcagaagt gctgcctctg 108480 gattgacttc ttcatcgtca tattttaatc cgtctgcagc atcagcagca tcaattaagt 108540 ctttaataga taacccatca gtctctggca taggttcact agcgagcttc tggagggctt 108600 cttcaatatc attaacgata ttatcaaaag atttattctt tttgactttt ataccaaact 108660 gttcagcata ttcagctaat ttagctttag cttctttatt atcatcaaga gccttcagct 108720 ctgcaatata atctttatct atcataatat ttcctcagta taaatataga tatatttatt 108780 actcggaaaa tagtatgtac cactttgtat atgaaacaac aaatctaata aatggtaaaa 108840 agtatatagg aaaacactct actgatgact tgaatgatgg ttaccttggt tccggtaagg 108900 caattcagca ggctataaag aaatatggtg aaaacaattt ctctagaaca atactaaaag 108960 agtttaaaac ttccgaagaa gcgtacatgt atgaagaaga aattataact cctgaactaa 109020 taaaaagcaa aaattattat aatatgaaac ctggtggaat tggtggaatt gttatgactg 109080 cagaggttat agcaaagatg aaagaatctt ccgctaagag atttgaaaac tcaccgggca 109140 cggtattagg tacaacttgt tacactaatg gaactaaaaa tatttttatt aaacctggag 109200 aacttgttcc agaaggattt gtaaaaggga tggttcatct taatagaaag tccagaaaag 109260 gatgtaaagt caaaccgact accacaggaa ctttttgggt caataatgga gcaataaata 109320 aattaataca accagacggt attattcccg acggatttat taaaggtcgt ctcatgaaaa 109380 gagactctaa aggcaaattt agtaaggcat aattatggat attaaagtac attttcacga 109440 cttcagtcat gtacgcatcg attgtgaaga gagcacgttc cacgaattaa gagatttctt 109500 ttcgtttgag gccgatggat ataggtttaa tcctcgcttc agatatggca actgggatgg 109560 acgaatccgt cttttagatt ataatcgcct tcttccattc ggtttagtcg ggcaaattaa 109620 aaagttctgt gataactttg gctataaagc ctggattgac ccgcaaatta acgaaaaaga 109680 agaattatca agaaaagatt ttgatgaatg gctttctaaa ttagaaatct attcaggaaa 109740 taaaagaatt gaaccgcatt ggtatcaaaa agatgcagtg ttcgaaggat tagttaatcg 109800 tcgtagaatt cttaatcttc caacatccgc aggtaaatct ttaattcaag ctttgcttgc 109860 tcggtattat ttggaaaatt atgaaggtaa aattcttatc attgttccaa caactgctct 109920 gacaactcag atggctgatg actttgttga ctatcgttta ttcagtcatg caatgataaa 109980 gaaaatcggc ggtggagcat caaaagatga taaatataaa aatgatgcac cagtcgttgt 110040 tggtacatgg caaactgtag taaaacaacc gaaagaatgg ttctcacagt ttggaatgat 110100 gatgaatgat gaatgtcatc ttgctacagg aaaaagtatt tcatctatca tatcaggttt 110160 aaataactgt atgtttaaat ttggtttgtc tggttcatta cgtgatggca aagctaatat 110220 catgcagtat gttggaatgt ttggcgaaat atttaagcca gtaacgactt ctaaattaat 110280 ggaagatgga caagtaactg agttaaaaat taatagtatt tttcttcgct atcccgatga 110340 gttcactact aaattaaagg gaaaaactta ccaagaagaa ataaaaatta ttactggact 110400 cagtaaaaga aataaatgga tcgctaaatt agctattaag cttgcacaaa aagatgaaaa 110460 cgcttttgtc atgtttaaac acgtatcgca cggtaaagct attttcgatt taattaaaaa 110520 tgaatacgat aaagtttatt acgtatcagg ggaagttgat accgaaacac gcaacgtaat 110580 gaaaacctta gctgaaaacg gtaaaggaat aattatagta gctagttatg gtgtattttc 110640 tactggtatt tcagttaaaa atctgcatca cgttgtttta gcgcacggtg ttaaatcaaa 110700 aatcattgta ttacaaacaa tcggtcgtgt attacgtaag cacggttcta agacaatagc 110760 aacggtctgg gacctcatag atgacgcggg cgtagtttct aaatcaaaaa catcttctaa 110820 aaaatactcg catttaaact atcttttaaa acatggactt gatcgtattc agcgttatgc 110880 tgatgagaag tttaattatg tgatgaaaga ggttaaactt tgaattataa attaatatac 110940 gataatttaa ttaatagagc ccagaatcgg gctcgcctta atggatacac tgaaactcat 111000 catataattc ctagatgtat gggcggtaca gatgataagt gtaatttggt agaactaaca 111060 gctgaagagc attttatagc tcataaactt ttagctaaaa ttcatccaaa ccattacggt 111120 ataattaaag ccgttatatg tatggggatg aattcaaaga ctcatgaaag acacgttaat 111180 aaatcttacg cctgggaacg tcgtaaaatg gcagaacttc aatcaggtga aggtaatcca 111240 ttttacggaa aacaccatac ggaagaacat aaacaatata tgtcaaaact catgaaaaat 111300 cgtccaatta catggggaag taaaattagt aaaactaaaa gaatgaaccc aacaaaatgg 111360 actgaagaag ctaaaagatt gcattctatc aatcaatcag gtaaaaataa tggcatgtat 111420 ggaaggaaac attccgctaa atctattcag aaaattaaag ataatatgcc agataattca 111480 ggagctaata acccagctgc taaacctata gaagtaaatg gtgttaagta taaatgtatg 111540 aaagatgctt ctaaagctac tggattatca atgtacaaac taagaatact tagaaaaaca 111600 gttaatttat aagggcttcg gccctttgga gaaaaagatg ttactagaat ttaaacaat 111660 tctttatgaa gcttctattg atgaatttat gggtaaaatt gcctcttgtc aaacattaga 111720 aggtttagaa gaacttgaag cttattataa gaaaagagtc aaagaaactg aattaaaaga 111780 tactgatgac atctccgtga gagatgcttt ggcaggaaaa agagctgaat tagaagattc 111840 agacgatgaa gtagaagaaa gcttttaaat taaaaaaggc ccaaccaaaa aggaagggcc 111900 aaaactatag actaaaggtc acactatagc aaaagttgtg tttcatttaa ttgttcttcc 111960 gaactttctg aaactggtag ttctttaatg taattatagc aaggcccagg atgtakhga 112020 cctttgtctg tttcaacaac caatgcagaa tcgattggag ttttacagac aacacaaatc 112080 ttatctgaca tgattgtctc ctctgaatta tatatctatt tatacaactc tcatatgcat 112140 atcaatgccc atatctttag aataaaaata ttcatcaaga tatccggcaa attttccttt 112200 aatataaagg acatcttcac tgcacgggtg gtcggccagg atacgaatat cctgacgctt 112260 aagattatac tttttcatta agaattgaat ttccgtttca aattcttctt cataattaaa 112320 agcatcatca atgttatatc tcattatttt ccagcctcaa atgcccgcat gtcttgaata 112380 tgcttaatag caaatccacg tgatttaata gcatcaagag ctccgctaca gaaatctaat 112440 aaaatccccc aatactgtaa cgaggtatca acctttaaaa catccttatc agctgataga 112500 actgttttca tttctgattt ctcataacga tccatactaa attcatcacc atctcctcgt 112560 cccgagtagt agtctaattt agctttaaga gcaacttttt tctgtgcttc aattctaagc 112620 atttcctttt taatacttga atgcttatta agccatttac tatataacat cacattatta 112680 gctgcttcat actgtaattt agtcgaatct ataaacacat ctttcttcaa ttcttcttga 112740 agatcttcta atctcatatt gttctctatt caattgttat tggatggact tagattcatt 112800 ataccacgtt ttaacgtgaa gcattatact ctattactgg aagccagttg cagttttatc 112860 tgctcaatat catcagggtt atcaatgacc gaaaagcgta tttctactat cagagtataa 112920 tcatcataaa ctggtattac attaactgct aatttatcaa tacgcggctc gtagtttctt 112980 actgcgcttt caatgttacg ctcaacagta tcagcagtaa gaggagtcat attctcaaaa 113040 agctgatcag ataaatcaca tccaaattcc gggtcaaatg gtctcgaccc ttttctggtt 113100 gtaataattc ccaaaaggct atttttaatt gaccttaatc caagagatct agaaacatct 113160 ttgtcccaat ccattttcat ttctgggtca atgtcagaat aaagcttatt aatatttgcc 113220 attacaatag ctcaaagaat tctttgagtc ctcttattac atgagcgtga gattttccac 113280 actctggaca cttaattgga acagccaaat acacagtagg ctttaaaagc atatctttta 113340 tagctacaat atctgactct gtgatgatag aatataaatc ttccaactct ttttcattta 113400 agtcttcaat tggaatgctt tcaccgttag catgaatcgt ttctatacat gatactatca 113460 tgtgggctat atttttatca tcaaaaattt tagggtaatg gaacttaatt ttaatgtcac 113520 ccagtgtata ccagaggtct tctggtgcat ctatttgtgt atgtaataga tttatatggg 113580 ttggtatttc agttccgcag gtgcacttcc aggagttttc gtgattaact tcgccgagag 113640 aatgtgccca taaatgaatc aacaatagtt ctgattcttg gcggtttaaa tcttttgcat 113700 ttgtgcagtc tttgattagc tttttaacaa ttacttctac ggaaccatta tttttggcag 113760 taataagttc tagatattct ttaagcgtga atgcgcgaca attgattatt ttagaaccaa 113820 ctctcacatc aaatttgtat tcatacatat tttagctcct ttatttatca tatttataaa 113880 tagaataaaa ggagcatcta tggcaaacat tattcgttgt aaattaccag atggtgttca 113940 tcgttttaaa ccatttacgg tagaagatta tcgagatttt ttgttagttc gaaacgatat 114000 agaacatcgg tcaccacaag aacaaaaaga aataattact gatttaattg atgattattt 114060 tggagactat ccgaagactt ggcaaccatt tatatttttg caggtatttg tagggtcaat 114120 aggtaaaact aaagtaccgg tcacatttgt atgtccaaaa tgtaaaaaag aaaagacagt 114180 tccatttgaa atatatcaaa aagaattaaa ggaacctatt tttgatgtag ctaatgttaa 114240 aattaaatta aagtttcctt ctgagtttta tgaaaataaa gcaaagatga ttactgaaaa 114300 tattcattct gttcaagtag atgaaatatg gtatgattgg aaggaaatta acgagtccag 114360 tcaaatagaa ctagttgacg ccatcgagat agaaacatta gaaaaaattc tcaatgcaat 114420 gaatcctatt aatttaactc tacatatgtc atgctgtaat aagtacatta aaaaatacac 114480 tgatatagta gacgtgttta agctattagt taacccagat gagatattta ctttttatca 114540 aattaatcac acactcgtaa aaagtaatta tagcttaaat tcaataatga aaatgattcc 114600 tgctgagcgc ggattcgtat taaaactgat tgagaaggat aaacaataat gagtatgctg 114660 caacgcccag gatatccaaa tctcagcgtt aaattatttg atagctacga cgcttggagt 114720 aataatagat ttgttgaatt agctgctact attaccacat taactatgcg ggattctctt 114780 tatggccgaa atgaaggaat gctgcagttt tatgattcta aaaatatcca tacaaaaatg 114840 gatggaaatg aaataattca gatttctgta gctaatgcaa acgatattaa taatgttaaa 114900 acacgaattt atggatgtaa gcatttttct gtatctgtag attcaaaggg tgataacatc 114960 attgctattg aattgggaac tattcattcc atagaaaatc ttaaatttgg cagaccgttt 115020 ttctctgatg caggtgaatc tataaaggaa atgcttggcg tcatttatca ggatcgcacg 115080 ttattaactc cagcaataaa tgctataaat gcttatgttc ctgatattcc atggactagc 115140 acatttgaaa actatttgtc gtatgtcaga gaagttgctc tagctgtagg aagtgacaaa 115200 tttgtatttg tgtggcaaga catcatggga gttaacatga tggactatga tatgatgata 115260 aatcaagaac cgtatccaat gattgtcggt gagccatctt taataggtca attcatccaa 115320 gaattaaaat atccattagc atatgatttc gtttggttga ctaaatcgaa tcctcacaaa 115380 cgcgacccaa tgaaaaatgc tactatttat gctcattcat ttttagattc ttcattgcca 115440 atgattacta caggaaaggg cgaaaactct attgtagtgt caaggtcagg tgcttattct 115500 gaaatgactt ataggaatgg ctatgaagaa gctattcgtc ttcaaactat ggcgcaatat 115560 gacggctatg ctaaatgttc tactgtcggt aattttaact tgactcctgg cgttaaaatt 115620 atttttaatg atagtaaaaa ccaatttaaa acagaatttt acgttgatga agttatccat 115680 gaattatcca ataataattc agtaactcat ctatatatgt tcactaatgc aacgaaactg 115740 gaaacaatag acccagttaa ggttaaaaat gaatttaaat ctgatactac cactgaagaa 115800 agtagttctt ccaataagca ataaagaagt ttctattcct aaaatgggtc ttaaacatta 115860 taacattttg aaagatgtta aaggtcctga tgaaaattta aaacttctta ttgattctat 115920 ttgtccgaat ttatcaccag cagaagttga tttcgtttcc attcatttat tggaatttaa 115980 tggaaagatt aaatctcgta aagaaataga tggttatact tatgacatta atgatgttta 116040 tgtatgccaa agattagaat ttcaatacca aggaaataca ttttatttta gacctcctgg 116100 aaaatttgaa caatttttaa cggtgagcga tatgttatcc aaatgcttgc ttaaggtcaa 116160 tgatgaagtt aaagaaatta attttcttga gatgccagca ttcgttttaa aatgggcaaa 116220 tgatattttt acaactttag caattcctgg ccctaatggt ccaataaccg gaattggcaa 116280 tattattgga ttatttgaat gaaaaagcca caagaaatgc aaacgatgcg tagaaaagtt 116340 atttcagata ataaaccaac acaggaagcg gctaaatccg cttctaacac tttatctgga 116400 cttaacgata tatctacgaa attggatgat gctcaagctg cttctgaatt aattgctcaa 116460 actgttgaag aaaaatcgaa tgaaataatt ggagcaattg acaatgtaga aagcgcagtg 116520 agtgatacta ctgctggttc tgagttaatt gctgaaactg tagaaattgg caacaatatt 116580 aataaagaaa tcggtgaatc actcggaagt aaattagata aattaacaag tttactagag 116640 caaaaaatcc agacagctgg aattcaacag actggaacta gtttagctac ggttgaaagc 116700 gctattcctg ttaaagttgt tgaggacgat acagctgaat ctgtgggtcc tttattaccg 116760 gctcctgaag cagttaataa tgatcctgat gctgattttt tccctacccc tcagccagtt 116820 gaacctaaac aagaatcgcc agaagaaaaa cagaaaaaag acgcatttaa cttaaaatta 116880 tctcaagctt tagataaatt aacaaagact gttgatttcg gatttaagaa atctatttca 116940 attactgata aaatatcaag catgctattt aagtataccg tcagtgctgc tattgaagct 117000 gctaaaatga cagcaatgat attggctgtt gttgtcggaa tagacctgtt gatggttcat 117060 ttcaaatatt ggtcagataa attttcacag gcttgggatt tgtttagttc aaactttact 117120 aaattctcta gtgaaacagg aacatggggt cctttattac agagcatctt tagttctatt 117180 gatgaaatta aaaaattctg ggaagaggga gattggggcg gtttgacggt agctattgta 117240 gaagggcttg gaaaggttct ttataattta ggagaactta ttcagcttgg aatggctaaa 117300 ttatctgctg caattcttcg agtcattcct ggcatgaagg ataccgctga tgaagtagaa 117360 ggaagagcac tagaaaattt ccaaaattct actggagcat ctctcaataa agaagaccag 117420 gaaaaagttg caaattatca agataaacga atgaacggag accttggtcc gatagcaaaa 117480 ggattagata aaattgctaa ttggaaaact cgtgcatcta actggattcg tggcgttgat 117540 aataaagaag cattgacaac cgatgaagaa cgcgcagcag aagaagaaaa attaaagcag 117600 ctttcaccag aagaaagaaa aaatgcttta atgaaggcta atgaagctcg ggccgcgatg 117660 attcgttttg aaaaatatgc tgattcagct gatatgagta aagactcaac ggttaaatca 117720 gttgaagctg cctatgaaga ccttaaaaaa cggatggatg acccggattt aaataattca 117780 ccggcagtta aaaaagaact tgctgctaga ttttctaaaa ttgatgctac ttatcaagag 117840 ctcaagaaaa atcagcctaa tgccaaacct gaaacttctg ctaaatcgcc agaagcaaaa 117900 caagtccagg taatagaaaa gaacaaagca cagcaagctc ctgttcaaca agcatctcct 117960 tcgatcaata atactaataa tgttgttaag aaaaatactg tcgttcataa tatgacaccc 118020 gtaacgagca cgactgctcc tggtgtattt gatgcgaccg gagttaatta aggaataata 118080 tggcaattgt taaagaaata actgctgatt taattaaaaa gtccggtgag aaaatttcag 118140 ccggacagag tactaaatca gaagtagcaa ctaaaacata cactgcccag tttccaactg 118200 ggcgtgctag tggtaatgac actacagggg acttccaggt aacagatcta tataagaatg 118260 gattattatt tactgcatac aatatgtcat ctagggattc tggaagtctt agatcgatga 118320 gatctaacta ctcttcttca tcttcgagta ttttaagtac agctagaaac actattagta 118380 gtacagtatc aaaactatca aatggattaa tatcaaataa taattcagga acaataagta 118440 aagctcctgt cgcaaacatt cttttaccga gatctaaatc tgacgttgat acatcatcac 118500 atagatttaa tgatgttcaa gaaagtctta ttagcagagg cggaggtact gctactggtg 118560 tgttaagtaa tattgcttca actgcagtat ttggggcact ggaaagtata acacaaggta 118620 taatggctga taataatgaa cagatttata cgacagctag aagtatgtat ggcggtgctg 118680 agaatagaac taaagtgttt acatgggatt tgacgccacg ttcaacagaa gatttaatgg 118740 ctattattaa tatctatcaa tattttaact atttttctta tggtgaaacg ggtaaatctc 118800 aatatgctgc tgaaataaag gggtatttag atgattggta tcgttctacg ttaattgaac 118860 ctttatctcc ggaagacgca gctaaaaata aaacactatt tgagaaaatg acatcgagtt 118920 taactaacgt tctagtagtt tcaaacccga caatttggat ggtgaaaaac tttggtgcaa 118980 catctaagtt tgatggaaaa acggaaatat ttggcccatg ccaaatacag agcatcagat 119040 ttgataaaac gcctaatggt aactttaacg gattagctat tgctccaaac ctccctagta 119100 catttactct tgagattact atgagagaaa ttatcacgtt aaaccgtgct tctttatatg 119160 cggggacttt ttaatgtatt ctttagagga atttaataat caagcaataa acgcagattt 119220 ccaacgtaat aatatgttta gctgcgtttt tgcgacaact ccatcaacta aaagctcttc 119280 gttgataagt tcaattagca acttttctta taataacttg ggtctaaatt cagattggtt 119340 aggattgact caaggcgata ttaatcaggg aattaccacg ctaattaccg ctggcacaca 119400 aaaactgata agaaaatcag gggttagtaa atatcttatt ggtgccatga gtcaacgtac 119460 agttcaaagt ttattgggct catttacagt tggtacatat ttaattgact tctttaacat 119520 ggcatataac tcatctggat tgatgatata ttctgtaaaa atgccagaga atagattatc 119580 ctatgaaact gactggaact ataattctcc taatattcgt ataactggga gagaattaga 119640 ccctttggtt atttcattta ggatggattc agaagcttgt aactatcgtg cgatgcaaga 119700 ctgggttaac gctgttcaag acccagtaac tggattgcgt gctttgccac aagatgtcga 119760 ggcagatatt caggttaatc ttcatgctcg taatggatta cctcatactg cggtgatgtt 119820 cactggatgc attccaatgt cagtgagcgc tcctgagcta tcatatgatg gagataacca 119880 aataactaca tttgatgtta cttttgcgta tagagtcatg caggctgggt cggttgatag 119940 acaagctgcg cttgagtggc ttgaatctgc tgctataaac ggtattcaaa gcgttctcgg 120000 aaatagtgga ggtgttactg gattatctaa ttcgctttca cgacttagta gattaggagg 120060 aactgctgga agcatttcaa acattaatac tatgacggga attgtcaact cgcaaagtaa 120120 aatattagga gcaatataac aatggggacc gaaaggtccc catattttta tttacggaat 120180 gaaatgaaag cagcaactga agcaactaaa ctgtcttcaa tataaacttc aatttttacc 120240 ggagcttctg actcaaattt acctgttact acaccttgga aaatgctttc agtctgttct 120300 ggctttgaaa aattttcaga aggaaaaatt ccgaactttt tatctgttcc aaaaattttg 120360 ataaattcat cataaactgc ttcattaaaa gcgttatcag caggaataac gccttcaact 120420 acaagttctt gacctaaaaa gcgtaaagaa gatttcattt tgtgttcctc atgttatgtc 120480 agtaagacta ctataacaca acacgaggga cttgtaaact acattttgaa ctttttagac 120540 attccgttga tgttaaccaa agaagctaag atttgagaaa cttcgttttc ctcttctttt 120600 gattcttcta caaggaattg attaaatcca gccattggac gaacttcacc agtttccatt 120660 agatggtcgc catcatatac tgattcttct aattgttcag aaggaggaac gattgtgcct 120720 tcaattagat acttgttata agcagtttct ttcatcatgt acgtgcttac tttattaatc 120780 ttcaacaaaa ttccacgcgg tagaataact tcagcttctg atggaaatcc tgataaatga 120840 cctggaacga taactttaat tcgctcagct ccttttatta ccatacccac gctagtttca 120900 gcatcttcat tagcatatgc ggaatgacta cccatatgca ttaaatcttc ggcatcaaca 120960 gaaccttctc cttcaccaga aaatactgcg ccggaatcat ctagagccat atagttttta 121020 ccatgctcac cgaagatatt tggtttaagc gatgttgata cgaagttctt gaaatagaac 121080 attttatttt caatattatg gcgtaaagtt ttaaaagtaa cttcttgtcc acgataaagc 121140 gtagttcccg gaggaagaac tgatcctttg gcgaatgcag aatccaacgt ctcgatgtgt 121200 ttaatagctc gttccatgta ttcttcacgg gtagaatctg gtttacccaa gaggaacgag 121260 ttcatttcaa catatgaatc tgcacaataa tcttcaatta catcagactc agcctgagtc 121320 agtccttttg gagttacttc ggtgcttgcg tattcatatg cctgagcagc agattcatta 121380 atcaatttat aaatgccatt catgacaaat tgaataatag ctaccttttc gtctggtgtg 121440 gctttagaac ctttaactaa atcattgata attttcttaa taacatcaaa gctattagaa 121500 atattaatgt cagcgagatc gctcaaaatt ttatcggttt tataatcaaa aaattcttta 121560 ttctttaaat attcttgaga accttgatgt gttatatcgc tctgcagtct gatagacgga 121620 tcacgtaaac gtgcatgggc caatgcaata tgatttcgga agctttctag ttcataatcg 121680 ttagatttaa aacgagaagc acttctcata ccaccgatag ctcctttgcc gaagtttgaa 121740 ccaatctgaa taacgccaga gttcattggt ccttctgctt tatatacagg aactttagat 121800 tcaaactctt gatatttctt ggcagcgaag ctatcaccct gaagtgaagc atcgacagta 121860 gaatattgag cttgcgctgc taatcgacga ctaattttag ttttctgaat aacagcttga 121920 tccgtgcgct tatcattttc taaagcaata gaagcagcaa cagcaacagc tttaggaaca 121980 gcattacctg ttttaacatc tacataaaca tcaccaacct ttgattcaac ttttgtgaat 122040 aactcagttg aaataggagg tacgcctgga atgtcttcta aattggcatt tttacggtaa 122100 accataatat atgcatactt tttatcataa tcccagattt cctttaaaag aacatatcga 122160 cctgctcctt tagtacgtac taaacgatca gcaataactt gcatttgacg agctgcgcca 122220 tttgttttac tttttagtac gcggaatagg catgcgtcaa ttttatactg tttcattgtt 122280 tgaagagcag tatcaaaaac cgcattaatg acaccaattg gatttccacc caagttttta 122340 agtttaacta atgatagttt ctcattaaca cctatcatta cgatatgcat cattttatcg 122400 cctggcttaa cgtttttatt tgtatcacca ccagaggtgt atgtacaaaa tctaaatcca 122460 ggaagcacac tttcttcgcc ggcttgaata gcaaaaattt gaggattatttt atgcttagga 122520 tttaagttaa caaccggcgc cgaagcgccg tcaaataatt ctgtaataag ttccatgatt 122580 tatccttgaa cgaacttgta aggcatgttt gtaatatcta tgcaagacgc aataattcca 122640 agagatgatt ctactttttg tttaacattt gatgaaacaa atgatgcaaa gtcaactctg 122700 tcttctattt caatatcacc tgtcattgca actacttcac cagtttccat tagacggtca 122760 ccgtcataaa ttactgattc ggtgagttct tccgtagtca taacttcagc ttgaatgagt 122820 tttgtattat tagatgttgt tccgtcatta ttagaagcat cagttatttt attaactttg 122880 accatcaatc cgcgtggtag aataacttca gcttctgttg ctattccgag acttcctgga 122940 tatacaacat taactttatg agctccatca attgcccatc ctatttgaac tttaacgtat 123000 tcaggatttt ctttatacgc tcttatttcg tttggattaa tagttattcc ttcttcattt 123060 ttatcaactg ttaattcatt acgagcttct ggttctaaaa gaccaatacc agcatgtgta 123120 attccaaaac gtccaaaaat gataggagtt aaagaagtag atacaaaatt tctgaaatag 123180 aatactttat ttttaactag tgcttcgtat ataggagcag tcatactttg agcacgataa 123240 actgtaatgc cttctggtat acggtcacca ttttcaaaag ctgaatctaa gttattata 123300 gcagattcaa tttctttttc actcattaca tcatatcgtt ctggattgta gcgtcctaaa 123360 agaagattat tgatgtcagt atatcctgaa ccgcaatact ctctaatgcc gcgcttttgt 123420 gatggagtat atttagaacc atcacgggca atagtaatat caatcattgg acctgcacca 123480 attccagaaa agctataaat cattcgtttg aggaatttag tttttgctgc gttccaggaa 123540 tttttagtta tttcttccca gacttcatct ggctgtcctt tacgggtttt attatgttta 123600 tcaagccaat tatctttata ttcttcaaag agttgattaa cagctgctgc gtatttctcc 123660 aaacatttta ttgaagtagt tggttcattt ttaatcgcat taagaattac atctttaatc 123720 ttttcagaaa cttcattaac ctcacttttt gaaaagaatt tatagtcata atgaagttca 123780 tctgcagttc cttcagcaat aatttttgct gccttagttt tagaagctaa tgaattaatt 123840 ccaagcttca tttcttctgc ttcgggaatt aaaggagctg tagcaggttt attgaaatta 123900 gctgcggtag attcatactt ctggaataat tcactttcaa atctagaaga ttctaatgat 123960 tgactttgtg caattgctct acgggaaatt ttaactttaa cgattacagc ttggtcagaa 124020 cgtttatcgt tttcttgcgc aatagatgct gcaattgcct catttttagt tacttgagct 124080 ccggtatctt tattgatata aacatcaccg accttcgatt caactttagt aaagagctcg 124140 gtactaattt ctggaactcc tggaatgtct tctagtgata catttttacg atgtataaga 124200 atatatgcat actttttatc gtaatcccag agttccttaa gaaggacgta tctgccacct 124260 gaacgactac ggataagtct atcagcaata acttgaattt gtcgagcttg gccagcagtt 124320 ttagacttaa gaatacgaag catacaagca tcaattttat attgacgcat tgtttgcatt 124380 gcaacagtaa aaactgaatt gatataatta attgggcttg gaccaagacc ttttaattta 124440 gcaattgaac ctttagcagt taatgtaaaa ggaacaatgt gcatcatttt gtcgcccatt 124500 tttaaatcgc gattagtatc acctccagat gtatatgtac ataaacgaaa gcctggttgt 124560 tcaattgcat catcaacatg aactgaaaaa atttgtggta ttttcttctt tggatttaag 124620 tttgtaatcg gaagagtagt atcttcgtca aataattctg taataagttc catcatagcc 124680 tctctagtgt ttattctatt tataaaatta aaggcccgaa ggcctttagt aatctagtgg 124740 taagagagta cgatatattt caaactttgg tcctttttca taggcatcaa atgtttctgt 124800 aaatttattg taagcatatg catctacaaa ttcgagaatg acttgtgata cagaagtaga 124860 aacatctcca ccttcttttt gagcaatgac aattgtttct aagtaagctt tcataaacca 124920 gttacctcat gaaaatcgcc aaatacatcc tcgaatgtat tagctttagt tttatcttca 124980 cgtaaacgaa tcgcaatcgg aagaaataat ttaacgtaat cagtgcggcc atcagatttt 125040 aaccaaccgt tgcattcgca ctctagaatt tttccaatat aataattttg gttttccata 125100 atgcgagtac ggtcaagttc atgcgatttt acaccagctt tatcttttaa gcctgaacca 125160 gcatttactt taatttttcc acactctgac tcaagaataa atccacccgc tttagtaggg 125220 tctttacggt gaggataaat tcctacaatt tttaaatcaa catcaattac ttctttaaat 125280 ttataaagat tttttgaacg agcattttcc cataatccat cgatattttt gagaataata 125340 ccttcaagac cttggtcaat atactttttg taaattacct tagcttcatc taggttattt 125400 actacctggt tttcaattaa aattacttta tcatatcccg atgtcatttg ttctagttta 125460 gaaaaacgta catcatattt caaacgaaat gctggaagac catatatttc tactaatgga 125520 acataatccc agacctgaaa cttcatgcat tgagcttctt tttctgaaat ggttcccttt 125580 aaagatttat tagcgattcc attagaagta gtacgtgatt cagctacttc ggcgaattct 125640 ttagctttac taatttcagg ataagcatca aaaagaaaat ctaggccttc tggttccttt 125700 tcaacttgct catggtatac caattcgcca tcaattaaca caccttctgg atgaatctgg 125760 cgagcttctg cagtcatttt gattaactct tccttgagaa gatctaatcc tagatattca 125820 ttaccagctc gtgataaaag acgaacatca tctaattcat cacctctgac ttcagcaaag 125880 caccgagctc catcagcttt taactgggca aaagctggaa atttgatatt cttattaatg 125940 cctttttcat cataagaact tgccagcatt tgaggttgtt caggaattaa acctggccaa 126000 actttgtttg caatagatac tgatgcacca cattcaaggt ctcgcatcat cacccgacgc 126060 aaaacttcaa catcatcttt tttaccgtca gcaatatatc cagttaattc ctcaattgcc 126120 gcatttccgg tcaatttccg agtagctaac gtgaattcaa tgaagtcaag catatcggta 126180 agagttaaca ttccaaaact ctgggtagaa atacccggtt taggccattt cttgatataa 126240 tactgcaacc cacgagaata agtcagacga tatactcgtt taagcaattc attatcttta 126300 ttcttttcaa gaattgcttg cttctgctta gttgaaccaa tagatgctat ttcgttcaga 126360 attttaagaa tcattgttca tcctttagag tttggtttac agctctatta taaatcaatt 126420 catcattaag ctcagtcaaa gacttgtggt acgtggttct aactttattt ccttgcatcc 126480 agtgcttgac gtaaatgaaa ccttgctcta cacatttttt aaaaattcgt tcgtcttttt 126540 gagctcggaa ttctggattg catctaaaaa attgatttac gtgaccgtaa tcacgtgtag 126600 tattaccttc attttcataa atagtgtgaa caacaaacat tagaatgctc cttggaaaat 126660 attatcacca ctagtaggtc tattatacaa atactctatg ccaccaggtt taatatagtt 126720 ccatgtctga aacggacgtg tctgatatgg atgatataga tgattataag gattaaatcc 126780 aggagttctc caggtagtgt tccaaggaaa agaatcgttt ttaaccatct tctcgattac 126840 atcttttata gctttttcac aatcaaaact ttctttattt tccttcggtg aaaaaagctt 126900 attctctaca tcattccatg tataaactcg ctgcgcagtt tttggaatac tgtcacgctc 126960 ccctcgagcc atccaataaa caggaacatt taatatttca ctcgcgtgat cgcagtggtg 127020 agcgagatcg tcaatataac aaattacgtt atatttctct tttgcctttt tgaacaactc 127080 ttcttttgaa gaatcatgac cacacatcaa tacttctgag aaggcaccag gaaaaagagc 127140 attcaaatta aattgacgat ttagcagagc gtcaatagaa tcacccaatg ctgtaacagc 127200 tacaaaatta taatcttctt ttaatttgtt aattacacac agggcatctt tatacggaga 127260 caagtaacga ataaaatctg aacgattata cttttcgatt aatttaacac caagttcttc 127320 atcgcaatta aagagcttac caggagaaat aaatttttcg tcctgaatca tttttaaaat 127380 atgttccaac ggaagattat atttttgggc aaaataagga aggcccgatt gccagcttaa 127440 acacaccccg tcaatatcag tcaaaatagt aggcttcata gagagtctct taataggttt 127500 aacacatcaa taaattcagc ttcggttagt attgtatcat cttttgttag accactagcc 127560 atgctatgct tcaaaacttt tcctttcgag gctagtaatg catcacgaaa gcccttgttt 127620 tgaatcgctg cttcaaaata tgcatttgtg tacaactctt tccacgctgg tgagtatctt 127680 gaaaacggaa ctccaagcca gaagagggtc ccacggtcct gagctctagc ataagacctt 127740 ccagcttgtt gggcggcaag cccggataac ccaaatacac gacgttgctg ttcaacattt 127800 ttcaccttac atccttggag gaatccttcg agacctccaa attgaatgcc atccataacg 127860 aaaggccaat aggcgaaatt acttaatgca catgatggcc acctaaaatt acttctaatc 127920 tctaactcag acattttcaa tgcttataat ttcaacatca gcccaatgac catagtttgg 127980 tagacgaaat tcaactggcc agtcactgcc tttttctaat ataatagact taacttgcgg 128040 ttcttcatgt tcatcagtat atggattttt atctgttact ttatatgtga ccttaatgta 128100 ctgaattcca aaaatcttat taattatatt catactaatt cctttaatcc gtaaatagga 128160 gataattcat cacccatacg aaggtcttca tttccatcta cccaggaaac aatataagcc 128220 tcttttattt gaacaccact ccatttaaat ggaggtagaa ccttagaaat taatccaggt 128280 ataccaactc cctttaattc aacagtttga cctaaaaaga atttcatcag aacctcatct 128340 gaaagccgtg tgatttaaca ttaccgccgc caatatcaga aatattaatt tcacgcgcaa 128400 ttgaagggtc aatgtcaatt tcacgattaa gtttagcgat agctaaagta tcacgcccat 128460 ttactgtacg gaattctaaa ggacaaacca catcaacata atttttaatc gattcactgg 128520 taggttgcaa atgagcagga aggtctttag gcgccttaga gaaaacaact tcacagaaat 128580 ttttgcgggt atcaaaataa gtagtcataa acatagtatt ttcctcagta aggggccgaa 128640 gcccctgttt tattttaaat atcaaattcg ttaagaacta catcaaagat tgcttcaaga 128700 tgctcaggtt tagctctgtt actcaaaata tgacgaatcc aagttttaac cagaagctta 128760 cgattagcgc cattccagca aggatgggtc cctaaatcgc gttgacgaaa atcatcatcc 128820 agagcgattt tgaagtttga accttccatt gtgattgaaa ccgtgatgcc attttcaaat 128880 cgcatataaa cgtagttagg agtcatatac tgttcaattt cgcatactga tccattttga 128940 tgtttccaaa ggcaaatagt atcaatagaa cctgcaatac cattagaaac atatttacgt 129000 tcaaagttga tgtagttcat ttttattctc cgagatgttt aattgcggta caggtatata 129060 atatcatatc ctgtaccaaa gtaaacaatt attttactac tttccagtgc ttcatgtcaa 129120 gtttaccaac ttttttcatc ttctcaatca aacgttcggc acgttggcga gctgtaacat 129180 aataccattc gcctaattca ttttgttcaa tttttccaac gattactgta ttcaattcat 129240 aaatccaacc agtaaagaaa ttatgaactt gaattgtaaa ggtgaaatct gttcccatac 129300 cttctgttgt ttctacttca ataatatcac cttcaattgc cattaagaac cacatagttt 129360 catcatattt accattgaag catttagtct taactgcagc gttcagatta atcgttttca 129420 ttttattctc ctttgtttgt gtaagataat actatcacaa aggaaccata ctgtaaacaa 129480 ctttatgcaa tctttggaaa ataaaaaagg actcccgaag gagtccttaa cttatgcttt 129540 ctgcttacca aaacgagaag catcatctcg aagaaccgca cgtgctcggc gcatgatctt 129600 ctcaacagtt tgattgatac gagagttcga cccacgcttg tagccagcgc gtttagaatc 129660 accaactttc ttttcaactg ctttctttgc tttagcttgt tttgccatta taaattctct 129720 tttaaatgaa aatgcaggac ttattggcat tgcctgcgca agccctcaag gggaacatag 129780 gtttggata tttaacgaca ggataaccat aaacccgtca tcattcacat tcaagaggta 129840 caccataaaa ctgccggggt cttaaaacta taatgattcg caaatcatta atcagacagt 129900 tcgatggctc ctcgatttta gctcacacta aggcagtgaa tctccaataa attacttcag 129960 tgttaccaca aagtgacgaa ctgcttttcg tgcagcagaa gccagaggct tagcatactt 130020 aagttcatct ttttcctgaa gctcagcagc taatgcagtt tgagcaggat tcagatgttt 130080 gaaataacgc aggatttcaa gagcttcggc ttcaacatca atagatgcgc catagttttc 130140 gtgaccatta ttccatgcgt ttcgttgcag ttcaagagcg tgttgtaatt gtttaatcat 130200 ttaaaaattc tcgttagaga ttaaaactcg gtagtcacgt tcttctgaat ttcatcttct 130260 ttcgacagat ctctcagttg tagactacca catagaattg ttcggttaac ttattattcc 130320 gacacccaat tcatattatt atttatatca cttataaaga cacggaatag ctttatagtg 130380 acaagtaacg aatttttgtt taatttcttt tggctgctta agacccagag ctacaaaagg 130440 atgcggaaca tttcgaattt gaccaactgg aagagaagtc aaatcaccaa cttcgcagaa 130500 accttcagga acatcaggac caacagagtg aattacacac agttcaggaa cttcaccttg 130560 aacacgttta ccgataataa gtcctgattc tgtaacttct tcatcaccgg cttgtgcagg 130620 ttcagaaact aaaataacat attcaccgac agcacgaatt ggtaactgtt gtacttcaga 130680 catcgttttt cctttttgtt aatagatgaa ttaataataa caaataattc ttaaagcatt 130740 tatttaccaa taaattggag taaatgctca actttcatac cattaacaga aatcaatttg 130800 tcaatagaaa aacctcgcca tgcaccaagt tcaacatcaa atactggaat catgtcagta 130860 gattctttcc gagtcgattc agtcaattta ccagtttgca tggttggcat aaagtctgcg 130920 tcacgagtac ctttcatagt acgaatagta ccatcagact tttcaaaaac tacgtttgaa 130980 acacccatgg acagtttagt tttcaaaatt tcacgaattg ctactttttg ttcagtcgtc 131040 agtttcattt atttacctat tacagtttta atatgagttc ttccacgttc tttaagagtg 131100 gaaagtaatt tttggcattt ttctaaatca gatttccaac tatatggtct atctatacta 131160 gtccaatcag ttttataata ctgtttccat ttagagaaaa aatatttctt atactctaca 131220 gcaaacgaga tgttctcgtt agaataagaa ctaattgctg taagctttac caaacgaaat 131280 ttcattattc accacagaat tcgttgatat tttcccagtt taacttattc aagtttttct 131340 taggaacatt aaacacttca atacctgcat ttcgcagaat atcatcccag ccaggtttat 131400 ttttatcgta tgtttcgcaa taaaccagtt ttttaatacc agattgagct atcgcttttg 131460 cacaatctgg acaaggagaa agtgttacat acatagtagc accttcaata gaagaaccat 131520 ttcgtgcagc aaacaaaatt gcatttagtt cagcatgaat ttcattttta gacgaccatt 131580 cagagtgagc gctccggtgt tcttttgcca agacaaaacg atcagttgaa ccaaatgata 131640 cacattcggg cttatgacct tggatgatag tatgtttagg cttattcagc aaccaacctt 131700 gctcagcagc ataatcacaa cagttcacac caccagcagg tgaaccatta tatccggtag 131760 aaataatacg tccattcttt tcaattactg ctcctacctt ccaggagcaa cattttgatt 131820 cctgcgatac taaatatgca atttgaagta ctgtactcgc tttcatttca taatcaccag 131880 ataagcagat ttagcagttt caacacgata aatttcgtga cgaagtttag ttatactttt 131940 aataacagaa ctaattatat tctgcccatc tttaaagcgg tttttcttat caataaaaat 132000 tgcgccaacc atctttttgt gaagctcaac tggatacttc gtcacaataa tagcatcata 132060 tacggaagga tgaatactat ttactagagt gtcattcatt aaagttattc taatgaactg 132120 tgctgtttca gagtcaagcg ctctatgatc gccagtatca ttttcaagac aattatcaat 132180 tatatcagtt aaattcatca tagtacgcca tacacccttt gtgcttcaac taatccatca 132240 aaatctaatt taagatgcga tatttgatcg ccatcacctg gattcacaat tactaatact 132300 gaacgaggag tttcagtaat aacacgaacc gatgtttcag gaaatcgttc agaaacctta 132360 tttaccaatt cctgtgcaaa tagcttaact ttttcttgga attctttaac agtaatcggt 132420 ttttcactta gcagcatttt gttttcctca tttgtttggt agagccataa tatcacaact 132480 ctaccataaa gtaaactatt aaatcgcttt gaattccgca gtttgagatt caaagcgaat 132540 gtcgcctttg ataactaact cagcatcaag accgaatacg acaatgatat gcgcggaacc 132600 tggatacagc gtaatggcaa cagaatccac ctggtctgga agcaaagtgt tcaatacatg 132660 agtcacttga gcatgaattc gaagctcggc tgcgttatca agcttttcaa acatattatt 132720 agcgataatt tgactaaaca ctacttctac aattttagaa taagtcggaa acatatttac 132780 ctcacataat tttcttcaag ccaatcaata acatccaacg cattatcaaa agttgaacca 132840 tctactttgt cttctgtttc ataatcaaga acatctaaac ctactcttcc atcaacaata 132900 ggccataaac aaaatagata tttcttttct ttttcaattt tatcacaaag acgataaatc 132960 ttttctaggt tattcataag ttttccatgg taaaggcagt ttagttttct ttactgttag 133020 ttcaacatca ggattctttt ctcttaattt aaggcattcc tcccaagctc tgatttcact 133080 agtgaataca caaaattgcc cattactagt accgactaaa ccactattta caataatagc 133140 ccaagtttca tgatgccacg ccattaaaaa tctcccgagt caacttgcca gcattcaaca 133200 ccgatgcggc gccacatttc aactacttga gttcggtcat caatagctaa tttcacatca 133260 aaatgtggtg cgatgtgttt ccagaaaatt tcttctttga ctacatcatc tttacgggta 133320 tcaccttgtt cgcgttgaca ttgcataact aatggaacgc cagcaatatc ctcaacccat 133380 ttacgggtca tacgataata tttcgttggg tcttcttcgg ttccactttc acggcctgaa 133440 acgactacga tgtaatatcc ttgcttatcg tacatcttag ctagttcaac aatcatagga 133500 ttgataacat cggtatcaca tttttcaagg tcataaggac cgcgaccatt catttttgct 133560 aatgtgccat caacatcaaa aataactgct tttggtttac caggagtccc tttatatacc 133620 ggaagaccga gatactctcg catgctttta tacattgagc gtaaaatatc aattggtact 133680 gctttagttc cgcgttttga gttgcgttta accaattcag tccaaggaac atcaaacact 133740 ttatattcaa tttgatgccc aagctctttg gcaaactctt cccagacctt acgtcgttca 133800 ggatttagat tagtatctga aacaattaca cccttcgtta tgtcttggca tagaatcatg 133860 ttagcaacat catgctgcat gtaagttacg atgccttctt tctttttggt atacttgtac 133920 tcgtcacgtt cttcatgacc catgatggat tgacgataat catcacgatt aatattataa 133980 aatccaggat ttttagcaat aaattcacga gcccaagtac tcttaccaga accaggacag 134040 ccaatagtca aaataatctt tttcatcatt taattcctaa gaaaacttca agaatacgaa 134100 tattatgctc acgccgtcct ttgtacaatt cagctgttga ttgattcgct gatttactct 134160 gaacattgga tgaaataaat tttatcatgt gatttttaag ctgatacata tcaagcccac 134220 gagctttcgc ttcttttcgc agggctttac cagcatcatc taaagcttta gcatgttcaa 134280 tatcttggct aatgcttgat acattttcac ggcatgcatc aatgtaacgg tctgaacatt 134340 caatataacg ttctaacaga gttttcattt atttttctca accaatgatt gaatataatc 134400 atgcaggtct ttagatgctt taccccactt attttgatat tcatttttga gattagcgcg 134460 tgattgagct aataaaacat cattagttgg aggtaaagat tctaatcgtt gaatctgtcg 134520 tccataaatc attgcagcca tctcggattc ataaattaat ccttttagat gttcaaattg 134580 ataccatgaa atcatttaca tttatcctct tttagctctt gacgataata acatatcata 134640 gttttctggt catgtacata tcgttttaca tcattaagcc aaatacgaaa ttcctgagaa 134700 tcttcaaatg gcatacctac ccaagcttta ccatcaataa ctttaacttg ccaagatagt 134760 ttagcttcgt catatgactt tatttgcaca ggccaattag gatgaactgt ttctttcttt 134820 acttctagag gctttgtcga acaaccaact agaagaccaa tagataatat tactgcagat 134880 aatttaatca tttagaaagg tcctggatgt cttctgcgaa cttgttgaag gagttgttga 134940 tttgtttttc aaccaatcct ggcttacgag ccaccacatc cgccttcttt gcatctttgc 135000 gcagtttttc attttcacgc tcaatagcag caatcgcctc acgattttta ttattcatcg 135060 catcaatata attatactga attcgcaaat tatttaatgc taaggcgttt tcattggccg 135120 tttttgtaat ttctacaaca gacgtttcta atctttctac cttatttttt aaaataatag 135180 atgttccgcc aaatgctatt acaagtaata gcaatccagc tgtaaaatta cttacatgca 135240 taaagtttta ataacctcta taatatcgtc ttgagaaaga ccgttaatta aaatatgatg 135300 ttcagccgga gatttagaaa ttttaaagca cgccgcaaca tcttctgcca tatccgatgc 135360 gctacgattt ggattactaa ttccaagacg atgctttcct gtcaaaggat taacgatgat 135420 atagcatttg cagctattga tatgaacatt aggttgagtc tgattaataa acacttcaca 135480 atcatactta gcgagttgat tttctaaaaa gactttcatc tcctcaaccg catcaggaag 135540 catatcacgg gcttgctcaa gacgacgatt tcgatattct ttaatggtcg ttttccgctt 135600 gacttgctta gctaaatctt tcttaagatc ggtgatatat ccaactcgac gatttccttt 135660 gaatacagaa atcccatctg tagtatcacc gtatgcttca acgaccattt cagtagtaat 135720 aatctgcaaa tccatcataa agtcctcatg ttatgtcagt aagattacta taacacaaca 135780 cgagggactt gtaaacagct tagtatcctt ctgggataaa ttttttataa tttttcaaaa 135840 aattctgttc gatttcgcac atgacctttt cttgactatc gtacccctga tataggctca 135900 taatgatacc gaacaggtga tccattccag cacctttagc aacaccttgc gcttccatcg 135960 cataagtctt tctatcctta ccacaatgct tattatgaca gtcaagaact aaaaacagag 136020 ctcggtctaa gtacttcaga taagtcgttt caaatgcttc aatttttctg tatgaatatt 136080 catcgtcagc atacattgct ttaagatcat ctgatgcacc atcaataata gtcttaaaca 136140 atttttctgg attatctaat gaactttttg tgctatgaag agacacgtac cagtcagact 136200 taattttaaa atgagaacca tctttcatca cagcaacata gccttcgatg ttttccgcat 136260 ttttagcttc ttctacccat ttagggctat cgatttcgta tcgttcaact agatatggac 136320 gaagagcagc atctttataa atatcatcat atgaaatgta ttcgcctgtt tcattttcac 136380 gaatattcaa taaaatgatt ttcatctctt gataagcaag aacgattcta ttagttggag 136440 cgacgaattc gaagttagca gtaaatccat cttcagctaa ttctttaagt ctatcacgca 136500 accgatggtg attaatattc atcaaaatac cattagccat taaagcctgt tcggatttga 136560 ttgaaccctt tgatttgaac agaatttcat caccatctaa ataagttgat accaaagacc 136620 catcttcctt tgtcagaatg taatcaacat catttaaatc gatattcatc gtgaatggat 136680 tttcgttcaa gttaaaaaac ttttccatgg gacgagaggc aattcttact ggtttttctc 136740 catccatttc aaacatgatt ccacgacatt ctagtgcgtc tggaagtaac caatcagaat 136800 aagatgcata attatatgag aaaattctgt aagttcttcc agatgcactt acatcatccg 136860 agtaaaaaaa cttacgctgt gaatccttac atagttccat taaattgtta aaaagttctt 136920 gcattgtgta tcctcttttg tgttttgaat atagtaccac actccatgtg gaagcatcat 136980 tttttcttgt gttgaatatt ccaaggcggg ttaaacagtt taatgaatag cggctcctct 137040 aggtcaatcg ttgcgattgt cattgtacct aactcatttg tcatagaaag attaaaacat 137100 tggcgggcgt aaaattcaac tttgcttcct tcctttagcg cagcatgaat taatgcagat 137160 ttagtagaat cagacgtttt gtctttacga ttaatagcag ttctataata atttattctt 137220 ttacgtaaat ttttagtttt tccaatataa acaagctcat catttatagc aatagcataa 137280 attacgttat acttatttgg aatagatagt tgttttatac ttccgttgtc gtctaattct 137340 aactcagtat atttaataaa tgaatattct gttgcaattt ctttcataat aaaatgggcc 137400 ttgcggccca ctccttaaaa gtatttttta aaactcatca taactttatc atcaacatca 137460 ttatcaatct gtgcaacaag ataagatgac agttctactt cttgcggcgc ggattgaaca 137520 ttatcagaat taaggtattc acgaatccaa ggatatggat gtttaaccgg agcatcggta 137580 atcgggcatg gaagaccaca ctgtttcata cgagatacag ttaagtaatc aataaagctc 137640 cacatgctat ttgtatttaa tccaggaaca tcgccatctt taaataaatg aactgcccaa 137700 tctttttctt gacggttaac ttccatgaaa atatcaactg cttcttgttc acactctttg 137760 gcaattttaa cccattcatc gccatcagta ccagattgaa gttgacgaat aatatattgt 137820 gtacctttaa gatgaagctg ctcatcacgt gcaataaatt tcataatctt cgcattacct 137880 tccatgattt ccatgttctt atggaagttg aaagtacatg caaaggatac ataaaaacga 137940 atagcttcca gagcattgat aacgtgcaga cagagataaa gcgacttcat caggtctcgt 138000 ttacattctt ccaaatgagt gagactgttt gaatatgctt ctaaatcata ttcattttca 138060 gcaaaataac taaagttttc tttggcgttt tcccaaatac gtgtcttgtc cagaacatca 138120 tcataataac gcccataga ttcagcacgt ttcatgatag ctttatctaa tacaatctca 138180 tcaaataccc ttgacggatc agtataaaga tttcgcataa tatgagtgta tgaacgactg 138240 tgaatagttt cactaaaagt ccatgtagca acccatgtat caaggcttgg gtctgaaatc 138300 aatgacataa gtacagcaga cggtgcacga ccctgaatgc tatccagaag tgattgatac 138360 ttcagattat tagtaaaaat attctgctga tattgaggaa gcttattaaa ctgtgcagca 138420 tccatcatta agtttacttc ttcaggacgc cagaaaaatg ataattgctt ttcggtcaaa 138480 tcttcaaaaa ctttatggcg ttgaatatca taacgcgcaa taccaagacc tgaaccaaaa 138540 aacataggtt cttttaaaac atcaactgga tttgtattaa aaactgtaga cattaatttt 138600 tcctctttaa aattctgccg cgtttccaac ctggcggtat aatatcatct ttacctataa 138660 gcgtgcattc acttccatta ttaatccatt tcttaccgcg gattccttta taatctcttg 138720 gttgattatttt gtcaaacttt gcatcaggtt gatatgccca tctaaatcca taggcatatt 138780 gaaatttacc ctcagcacaa tatttgatat ttgacccgtt tccattaact gacctggacg 138840 ctgccgcaat agagtgaaag gtttctatga aatccccatc taatgagaat ttatgtattt 138900 cgatagatgg gcatgcatac ctattcacgt ttgatacatg tcgtttagtt tcgtttttat 138960 gatgcttgcc taacattcct ctaggatgag gattattttt ccagtatttc ttaaagaaat 139020 cagaattagc tttagcaaat aattttctgt gcaagctata caatctgtta ttaattctat 139080 taccagcttt atctgttgcc attaacgtta acgcagaggc aagcccaaaa tggccttcat 139140 ttatcttaca tagtaataga tgcgctataa aatgttctct agctgttaat tcaactaaat 139200 tttctttatc atcagaacct cccatgcatt tagggactat atgatgtgtc tctttatatt 139260 cggataaagg ttcccgagcc tgagctcggg aaattaggtc gttatagatt ttttgataat 139320 tcattacaat ttacacgctg cacaatcgtc ggcttttgga gtttctattt cataatcatc 139380 agtaccggaa ccatcacggg tattatgata atagaaattt ttaatgccat aataccatcc 139440 gtatagcata tcatcaatca ttattgacat tggaaccttt ccttttggaa aaatctgcgg 139500 gtcataatat gtattcgctg aagctgattg acatacccat ttaagcataa tagctacctg 139560 cgtaagataa ggtttattac ctttcttagc taatttccat gtataatcat agaggtctat 139620 gttatgttca atattgggca cgacttgatt aaaggaaccc tcttttgatt ctttaacaga 139680 gactggtcca cgtggaggct cgataccgtt tgtactgtta gaaacttggg aagatgactc 139740 acatggcata agtgctgata atgtgctatt acggatgcca aagagcttaa ggtcttcccg 139800 cagctccgac cagtcacaaa cgtattttgg agctgcgatt tggtcaatct ttttattgta 139860 ccagtcgata ggtaattcgc ctcgagacca acgagtgtct gaataatatt cgcaaggtcc 139920 tttttctttg gcgagcttaa tggatgcttt aatgagccca tactgtaatc tctcaaatag 139980 ttcatgtgtt aaatcgttag catcttcata agaagcaaag ttacttgcca gccaagctgc 140040 atagttagta acacctacgc caaggtttcg acgcttttta gctttttctg cttcaggaac 140100 tggatatcct tggtaatcca aaagattatc aagagcgcga acttgaactt ctgctaattc 140160 attaatttta tcttggtctt gccaatcaaa gttatccaac acaaatgcag ataacgtgca 140220 caatccaatt tcagcatcag gactattcac atcatttgtt ggaatagcaa tttcacaaca 140280 caggttactc tgacgaatcg gtgccttttc acgaataaat ggagtatagt tattcgtatt 140340 atcaatgaac tgtacataaa tccttgctgt tcctgagcgt tcagtcatga gcaattcaaa 140400 cagttcacgg gctttaatac gctttttacg aatattaggg tctttttctg cagcttcgta 140460 taattcacgg aaacggtctt ggtctttaaa ataagaataa taaagctcgc cacccatttc 140520 atgcggactg aacaaagtaa tgtagtcgtt ctttccgaat cgttccatca tcaaatcatt 140580 cgctggaca ccataatcca tatggcggat acggttttct tctacgcctt tgttattttt 140640 caaaacgaga agattttcaa cttccaaatg ccaaatagga taataagcag tagcagcgcc 140700 gccacgaatt ccaccctgtg agcatgattt aacagcagtc tgaaaatgtt tccaaaaagg 140760 aataacacca gtatggcgta cttcacctgt gccaatctta gaaccttcgg cacgaatcat 140820 accaacgtta ataccaattc cagcgcgttt ggagatatat tcaacaattg aagcggaagc 140880 cttattgata gacttcagcg aatcacctgc ttcaataaca acgcatgaac taaactgccg 140940 ggttggagta cgacatccag ccataatagg agttggcaat gaaatctgtc gagtagatac 141000 cgcttcataa aaacggataa cgtgttttaa tctatcaaca ggttcatctt gatgcaatgc 141060 cattccaata gtcataaatg caaactgtgg agtttcataa atttgaccag tggttttatc 141120 tttaactaga tatttttctt ttaattgcat cgccccggaa taagtaaatt ccatatcccg 141180 ttcatgctta atttttgatt ctaaaaatgt aatttcttct gctgaatatt ttgacaacaa 141240 ttcagggtca tatttacctt catttacgca gtaagaaata tggtcaataa atgaacgtgg 141300 ttcatactgt ccataaacat gcttacgaag agcgaacatt aaacagcgtg cagctacgta 141360 ttgataatca ggctcttcaa ctgaaataga attcgcagca gccttaatta caatggtttg 141420 aatgtcatca gttgtcattc catcacggag atatgattta atattttcat ataattcata 141480 aggatctact gatgttcctt cagctgccca agataaaact ttaataattt tttgtgggtc 141540 aaagctctga gaaacaccac tacttttgat aacattaatt aattgcataa gtcctcaact 141600 tgaaaatcgt ctttaaacaa tcggttaact atatgagcta ttatatcacc atgacacggc 141660 ttcagtttac atgtgcatcc tagcctcatt ccacgtaaag gctctaaatg tgctttagtt 141720 atttctccgg atttaattcg acgtataaaa tcttttttga ataattcaat ggcagcctcc 141780 cggctgccag catctttacc gacgtaattt ccccaaaatg taccacggtg aatattaaca 141840 tcaaagtcgg atttatattt attcactacc tgacatagac ggcccgcgcg gtgataattc 141900 gtcatattgt ttttccgtta aaacagtaat atcataataa caatcagaag aagttttaac 141960 tgtagaaatt ttattatcaa aatactcacg agtcatttta tgagtataat attttttgcc 142020 ataaatgata ataggctgat ttggtcctgg aacttctaac tcgcttggat taggaagtgt 142080 aaaaagaacg acaccagaag tatctttaaa tcgtaaaatc atatatcctc gcaataataa 142140 aattacaccg ccatctttcc tttaatagga ggatgtgatt catagttgtt aagaacaaaa 142200 ttatgaggct ttgcaaattg actcaaccaa aatacctgcg attctgtgtc ccattcatca 142260 aattcatctg gaaattttaa ttgtaattcg cataaatcca taggttcacg acataaaatt 142320 tctttacatt gttctacgtg attcatatag atatgagtat taccaccaga aaatatcaaa 142380 tctccaggaa taagattaca catcttagct acaatatgaa ctaacgtagc atatgatgca 142440 atattaaatg gtagcattat gttcagataa ggtcgttaat cttaccccgg aattatatcc 142500 agctgcatgt caccatgcag atcagactat atctccaact tgttaaagca agttgtctat 142560 cgtttcgagt cacttgaccc tactccccaa agggatagtc gttaggcatt tatgtagaac 142620 caattccatt tatcagattt tacacgataa gtaactaatc cagacgaaat tttaaaatgt 142680 ctagctgcat ctgctgcaca atcaaaaata accccatcac atgaaatctt tttaatatta 142740 ctaggctttt tacctttcat cttttctgat attttagatt tagttatgtc tgaatgctta 142800 tgattaaaga atgaattatt ttcacctgaa cgatttctgc atttactaca agtataagca 142860 gaagtttgta tgcgaacacc gcacttacaa aacttatggg tttctggatt ccaacgcccg 142920 tttttacttc cgggtttact gtaaagagct ttccgaccat caggtccaag tttaagcatc 142980 ttagctttaa cagtttcaga acgtttctta ataatttctt cttttaatgg atgcgtagaa 143040 catgtatcac caaacgttgc atcagcaata ttgtatccat taattttaga attaagctct 143100 ttaatccaaa aattttctcg ttcaataatc aaatctttct catatggaat ttcttccaaa 143160 atagaacatt caaacacatt accatgtttg ttaaaagacc tctgaagttt tatagaagaa 143220 tggcatcctt tttctaaatc tttaaaatgc ctcttccatc tcttttcaaa atctttagca 143280 cttcctacat atactttatt gtttaaagta tttttaatct gataaattcc gcttttcata 143340 aatacctctt taaatataga agtatttatt aaagggcagt cctacaattt agcacgggat 143400 tgtctactag agaggttccc cgtttagata gattacaagt ataagtcacc ttatactcag 143460 gcctcaatta acccaagaaa acatctactg atcgctgata ccactgcaga tccaaatagc 143520 cattacgcac attaaattga tagaacatat gacaaggtgg taatgccatt tgcttgagtt 143580 ctgccggatt ccatgctgaa acaatttgac gtctatcatt tggcagtttt ttaatacgtt 143640 caacaacttc tataatttga tctacgccac caaaatcgcg ccactgtttt ccataaattg 143700 gaccaagttc accgctatgg tatcctaaat cttttgcttg attttcgtaa ttttcatccc 143760 aaactgtttt gccttggatt aacgaatcat gttgaattaa tcgcaaatca ttgacatttg 143820 tgcttcccga taaaaaccat attagctcag caatacaggc tttccatgct aattttttag 143880 ttgttaccac aggaaaacct ttagttaaat cccagcgtaa tttagtaccg aacaaagcaa 143940 ttgttcctgt gcctgttcgg tcatcggttt catagccatt ttccagaata tctttaatta 144000 aaaattggta ttgtttcatt agttcatcca agaatatgta gaaggatatt tggcaaagtt 144060 aggtttatat cctaatttaa ccatttgttt tgctttgcga gtaaatccta aagaacgctc 144120 acctttaaga tactgttttg gtgtcatagg cccttgatgc atctgccgac aaataaaaag 144180 ggccatagca ttaggaacat ccttaacttt taatttattg ctcatttata tactgattcc 144240 gtaagggttg ttacttcatc tattttatac caatgacttt caaccatttc acgtttgctt 144300 atatcatcaa gaaaacttgc atctaattga accgttgaat taacacgatg ccttttaacg 144360 atgcgagaaa caactacttc atctgcataa ggtaatgcag catataacag agcaggacca 144420 ccaattacac ttacattaga attttgatca agaatagtct cgaatggcgc gccagaaatt 144480 gacacttgaa tttcgtcgcc agaaatgtaa tctatatatt gctcccatgt aatatagaaa 144540 tgtgctaaat cgccgtcttt agtttcagga taatcacgcg caaggtcgca cactacaata 144600 tgactacgac ctggaagtaa tgtaggcaat gactggaacg ttttagcacc cataatcata 144660 gttgtgcctt cggtacgagc tttaaaattt tggaggtcct ttttaactcg tccccatggt 144720 aaaccatcac ctaaaccgaa tgctaattca ttaaagcctt cgaccgtttt agttggagaa 144780 taagcgaata ccaatttaat cattacgcaa aacccctttc aataaaccat tcagtggctt 144840 tattagcatc aaagaataat tcttcatatg tcttttcttt gttttcaaag actgtcacac 144900 aaacgcgttg acattctccg cagtattctt ctgacatact caaagcatca gaaaacattt 144960 cattaaattc atttaaatca ggattatgca atgcgttaaa aattgcataa tcgaattcat 145020 cattcataaa ttcaaataca aaaatcatat tatctcctaa tataaaggat cgggaacata 145080 tccactggct ttaatcattt taattaacgt tagcagtcct ttattaactg cttgtgagat 145140 ttcatcaaaa acttcatcac taaaaagttc taacacgccc ttctgaactt ttaatttaca 145200 accaataatt tcgtcatcgc ctatagtaaa ttcgtttccg ccaattccac cgaaaaactt 145260 aattacgcca gttaactgtc ttccacgaga atatgggtcg tgtgataaag taatatgagt 145320 caccccaggt acagttttaa attggcagcg aatgtttact tgggaaattc cagttacgtg 145380 aatgtcagac ataatatttt cctcaaacag actttttcac aattttccaa tcagctttaa 145440 actgttcaac gtcagaatga taaatccaga atcctgcgct ttctccatcc tcataaagag 145500 ggcacccatc gcattcatct tcccatccca tatcacgcaa aagacgttca gctttttcaa 145560 caagttcaga atctttaccg atgatattaa aataccattt acctctaact tctgaatctt 145620 taatgctctg acgttgtaat ctcattttat tctccttagt tgatagggta atagtatcac 145680 actactaccc ttctgtaaac tactttttga aagtttttcg caaaagttca atgatttcat 145740 ctacattgtt ttcgtctaca atgcagtgaa tttttgttac gccagaaatc ttgtctttga 145800 cttcatcttc ttcagaagtc gattctttat actcacgaaa acaatgaaat tcatcttcac 145860 aaatttctaa aagtctatct ttgaggtaaa aatgttttcc atttgcgcat tcaatgtgtt 145920 ttactgcttt atatccatta gcgacggaaa cttctttaac ttcaaaccat ccgccattat 145980 ctcgaatagc tttaactatt gatgaattag aacgtgggct ataattaata aatgtatcaa 146040 taagtcttgg aacaagttca tactttctac cagtatacat tgtgtttcct cattttaata 146100 ggggcttgat agccccttaa taattattgt tcgatcagtc ccatgtaaaa ttctgcgtct 146160 tcagaatcca tgccgtcaca atactcattg gccataaagc gggtgaggtc ttcaagagga 146220 ccttcaataa cgatttgaat actccaaaac ttagaatctt gtacgcttgt gatactaagt 146280 tcaggataac gattacgaat aatttcttca atatattcga aatcaacaat gtcaatatca 146340 actttagcca tattattttc ctctttaatc gtcagcagta ttgccgatag ttgtatagta 146400 ccatagaaga acagagatgt aaacagtttt gtgaaaaaaa tttttttgaa ataaaaaagg 146460 ggacctctag ggtccccaat taattagtaa tataatctat taaaggtcat tcaaaaggtc 146520 atccaggtcc gtgtcatcag cactagatga actgccagag cttgagctca taaaatcatc 146580 ttcagttttt gttttgaagt catcaacatt gaatgcatcc aaatcatcag caactttatc 146640 agctttctta gcagcagttg ctgcggcacc gcccatagca gcagttccca taacttgact 146700 gaacttagtg ctcaattctt caaacgattt gaatttatct ttagaagtca tttcagaaag 146760 gtcaaccatt tgttcgaaca gttctttctg gaaagattca tcatcaatgt ttggaatcgc 146820 agattgattc aggaatttag attcgtcgta gttactaaaa ccagaaactt gtttaacttt 146880 cagtacaaag ttagcacctt cccacggaca agttacatca accggagttt cacccatttc 146940 aacatcaact gcaatcattg cgttgatttt atcccagatt ttcttaccga agcggtattt 147000 aaatacttta ccttcatttt ctggagcagc tgggtctttt actacaagaa tgttagccca 147060 gtaagaagtt ttacgtttaa caagaccgta ctctttattg tcagtgttgt acaaatcatt 147120 tttactgatg tactgacata ctgggcaaga atcgtaatca ccgtgggtag atgaacagtt 147180 ttcaatatac catttaccat ttttcttgaa accgtgattt acaagaattg cgaatggtgc 147240 ttgttcatca tttttagacg gaagaaaacg aattactgct tgaccgttac ccgcattatc 147300 gagtttcagt ttccactcgc ctttatcttc agaagaaaaa ccacctttat ttccagccag 147360 tttagccatt tgtgcagcga gttcagcagt agatttacgt ttaaacattt ttatttcctt 147420 tttaatttaa ttaacagttg gtgctatgac gatgtatgac ctcatagctg gtcagtgaga 147480 taattataat ctatttataa taagcaatta atacttgcaa gatttcacaga tttcaatgaa 147540 aacacttttg gctttctgtg aatcaatatt taaaattttt ctataagctt ttaactttat 147600 agaataatta ttccagacta aattatcagt ctgttcatca tgtttatcaa ttatatttaa 147660 aaacgaatca agcaagataa acgtctcaaa cgaaattata ttcgattgaa gtagtttaaa 147720 aatataactt gattgaactt ttggattata ttcaaaaatt tctttaaaag cagaaacttc 147780 aactttttta ctaaaatagt aaatattgcg aatatcttct tcaaacttaa atttaatttg 147840 ccttaagcgt ccgatatatt cacgataaaa cacaagtgca tcagcgtcag agatgtcacc 147900 aatccaagca tcctggttag caaccagatt gcttataaag attaaagcaa gttcctttaa 147960 tttatatttt tctgataact tctggaaaaa atacttatcc cttcgctttt gataagcggc 148020 atcagacacc cgcatgcacc aattatactt aattacatca tactttccat tcatatgttg 148080 ttttatcatt aagtataatt tataaactga tttaccatca atatatcttt caccaccagc 148140 aggcatgcgg agtttaatca tagcagaaaa tctaatgtat tagttttttc acaacgaaca 148200 acagaaggac gtaaaagatt ttcgtcaata gcttctgact gaattttttc gattataccc 148260 gaaggaataa atttagcaaa ttgagtttca ggaatagaat tttcttctaa gaatgctgtt 148320 gtagcttcaa gataactcat tccaaactct tctaccattt tttcaataat aaatccattt 148380 tcttgacgat caagaagctt tgttatttca tccttttctt tcttgattga aagttctttt 148440 tctgaaagac cggtctcatc gaccggacga atatcattta gagaaaactg tgtcataaag 148500 ttcaactacc tcttcagttt cagcttcaaa cacatcacgg ttatctttat gatacaaagc 148560 taatagacga ttaaacatct taccatcaac gccaagttca tctttggcac gaattcgaat 148620 atctttaatc agttcattat aaccggaaat tttcagttta tgatcagatg cttctttaat 148680 aaatttagcc aagtcttcgc catggatagc ttcatcaaat tcaaccattt cttttttagc 148740 cattattcac ctcaaaattc attaatgcta ttagttaatt tagaaagacc cgcttttaca 148800 aaatatgaat aaattttgcc acgcggtggt aatttatatg aattatagta attcacaatg 148860 tttgaagcaa tattatcagg aatataatca aaatcaatta gaactaaatt ttctttataa 148920 cgattatatt cagattctgt gagaagcacc ttagcttgct cacggtcatt agcaatggct 148980 tcaacgattg aagttttcat tgaaggagtt cgttcacctt caactttggt aaaccaaaag 149040 tcagatcgca ctttaactga agcaacgtta tcctttttgt cgcctttaag gattttagtc 149100 atacagtcaa tttcagcaga accgctttta attttaaccc atttcttgtg catcggtgac 149160 cattgcttaa catttgggta tttgtgaagt tgagtaaagt caccatccga tgaaatgatt 149220 aaaatcttat gcccttctaa agagaacttt ttaacaagaa cagcaatatg gtcatctgct 149280 tcatacttat caatatccat aacgatgtat ggcatataag ctttcaattc atctataact 149340 ttatgactgg attcaaaata accttcccag tcccaagtag attcttctcg tgcttttcca 149400 cggtttttct tataataata ggcgaaatca cgacgccaat atccagattt cgcgttatca 149460 atacacagta caattttagt gtatccaagc gtttttgctt ttttgacatt aaacttaatt 149520 gagttcaata tcaaatgacg aaccattgat aaattaattt tttctttatc tggaaagttt 149580 actagagcag tcgaaagtgc aatttgacta aagtcaatta agcaaattcc ttctttgtaa 149640 tcttcatcca gcatcatttc taaatccata tgaacctcgt tcaattagtg agatttctat 149700 tatatactat ccaaatctta aagtaaacaa gtataaatac ttattattga aaacacaata 149760 ggagcccggg agaatggccg agattaaaag aaagttcaga gcagaagatg gtctggacgc 149820 aggtggcgat aaaataatca acgtagcttt agctgatcgt gccgtaggaa ctgacggtgt 149880 taacgttgat tacctaattc aagaaaacac agttcaacaa tatgatccaa ctcgtggata 149940 tttaaaagat tttgtaatca tttatgataa ccgcttttgg gctgctataa atgatattcc 150000 aaaaccagca ggagctttta atagtgtaca atggagagca ttacgtactg atgctaattg 150060 gacaactgtt tcatcaggac cttatcaatt aaagtcaggc gaatcaattt cagttgatac 150120 tgcagctggt aatgacatta catttacttt gccatcttct ccaattgatg gagatactat 150180 cgttcttcaa gatattggtg gaaaacctgg tgttaaccaa gttttaattg tagctccagt 150240 gcaaagtatt gtaaacttca gaggcgaaca agtacgttca gtactaatga ctcatccaaa 150300 atcgcagata gttttaattt ttagtaatcg tctgtggcaa atgtatgttg ctgattatag 150360 cagagaagct gtagtcgtaa caccggcaag tctttatcag gcgcaatcta acgattttat 150420 cgtgcgcaga tttacttcag ccgcggcgat taatattaaa cttccgagat ttgctaatca 150480 tggcgatatt attaatttcg tcgatttaga caaattaaat ccactttatc atacaattgt 150540 tactacatac gatgaaacaa cttcagtgca agaagttgga actcattcca ttgaaggccg 150600 tacatcgatt gatggtttct tgatgtatga tgataatgag aaattgtgga gattgtttga 150660 cggggatagt aaagcacgtt tacgcattat aacaactaat tctaatattc gtccaaatga 150720 agaagtcatg gtatttggcg cgaataatgg aacaacccaa acaattgaac ttcagcttcc 150780 aaccgatatt tccattggtg atactgttaa aatttccatg aattacatga gaaaaggcca 150840 aacagttaaa atcaaagctg ccggtgaaga taaaattgct tcttcagttc agttgttgca 150900 attcccaaaa cgttcagaat atccgcctga agctgaatgg gtgactgttc aagaattagt 150960 ttttaacggt gaaactaatt atgttccagt tttacaactt gcttatatag aagattctga 151020 cggaaaatac tgggttgtac aacaaaacgt tccaacagtt gaaagagttg attctttaaa 151080 tgattctact agagcaagat taggcgtaat agctttagct acacaagctc aagctaacgt 151140 cgatttagaa aattcccgc aaaaagaatt agcaattaca ccagaaacat tagctaatcg 151200 tactgctaca gaaactcgta gaggtatcgc aagaatagca actactgccc aagtgaacca 151260 ggatactaca ttctcttttg ctgatgatat tatcgtcact cctaaaaagc tgaatgaaag 151320 aactgctaca gaaactcgta gaggtgttgc tgaaattgct acgcaacaag aaactaatgc 151380 aggtactgat gatactacaa tcatcactcc taaaaagctt caagctcgtc aaggttctga 151440 atcattatct ggtattgtaa cctttgtatc tactgcaggt gctactccag cttctagccg 151500 tgaattaaat ggtacgaatg tttataataa aaacactaat aatttagttg tttcgcctaa 151560 agctttggat cagtataaag ctactccaac gcaacaaggt gcagtaattc tagcagtcga 151620 aagtgaagta attgctggac aaagccaaga aggatgggca aatgcggttg taacgccaga 151680 aacgttacat aaaaagacat caactgatgg aagaattggt ttaattgaaa ttgctacgca 151740 aagtgaagtt aatacaggaa ctgattatac acgtgcagtc actcctaaaa ctttaaatga 151800 ccgtagagca actgaaagtt taagtggtat agctgaaatt gctacacaag ttgaattcga 151860 cgcaggcgtc gacgatactc gtatctctac accattaaaa attaaaacta gatttaatag 151920 tactgatcgt acttctgttg ttgctctatc tggattagtt gaatcaggaa ctctctggga 151980 ccattatacc cttaatattc ttgaagcaaa tgagacacag cgtggtacac ttcgtgtagc 152040 tacacaagtt gaagctgctg caggaacatt ggataatgtt ctaataactc ctaaaaagct 152100 tttaggtact aaatctactg aagcacagga aggcgttatt aaagttgcaa ctcagtctga 152160 aactgtagct ggaacgtcag caaatactgc tgtatctcca aaaaatttaa aatggattgt 152220 gcagagtgaa cctacttggg cagctactac cctggtaaga ggttttgtta aaacttcatc 152280 tggttcaatt acattcgttg gtaatgatac agttggttca acacagtcat tagaattata 152340 cgagaaaaat agctatgcag tatcgccata tgaattaaac cgtgtattag caaattattt 152400 gccgttaaaa gcaaaagccg tagatagtaa tttactggat ggtctagatt catctcagtt 152460 cattcgtagg gatattgcac aaacggttaa tggttcacta accttaaccc aacaaacgaa 152520 tctgagtgcc cctcttgtat catctagtac tgctacgttt ggtggatcag tttcagcaaa 152580 tagtacacta accatttcta atactgatgg aacagcaact cgtctgattt ttgagaaagg 152640 acctcaaact ggaacgaacc cggctcaaac gatgacagtc agcgtgtggg ggaatcaatt 152700 tagtggggaa tcaaacacaa cacgttctac cgtatttgaa gttagtgatg aaacatctta 152760 tcacttttat tctcaacgcg ataaagatgg taatatagca tttagcatta atggtactgt 152820 aatgccaata aatgtgaatg ctttaggttc tttgaacgcg aacggcgttg caacattcgg 152880 tagttcagtt actgctaatg gcgaatttat cagtaaatcg tcgaatgctt ttagagcaat 152940 aaacggtgat tatggattct ttattcgtaa tgatgctgct aacacctatt ttatgcttac 153000 tgcatctggt gatcagactg gtggatttaa tggattacgt ccattatcaa ttaataatca 153060 atctggtcag gttacaattg gtgaaagctt aatcattgcc aaaggtgcta ctataacttc 153120 aggtggttta actgtcaact cgagaattcg ttctcagggt actaaaacct ctgatttata 153180 tactcgtgcg ccaacatctg atactgtagg attctggtca atcgatatta atgattcagc 153240 cacttataac cagttcccgg gttattttaa aatggttgaa aaaactaatg aagtgactgg 153300 gcttccatac ttagaacgcg gtgaagaggt taaatctcct ggtacgctga ctcaatttgg 153360 taacacactc gattcgcttt accaagattg gattacttat ccaacgaccc cagaagcgcg 153420 caccagtcgc tggacgcgta catggcagaa aaccaaaaac tcttggtcaa gttttgttca 153480 ggtatttgat gggggtaacc ctcctcagcc atctgatatc ggtgctttac catctgataa 153540 tgctataatg gggaatctta ctattcgtga tttcttacga attggtaatg ttcgcattat 153600 tcctgaccca gtgaataaaa cggttaaatt tgaatgggtt gaataagagg tattatggaa 153660 aaatttatgg cagagtttgg acaaggatat gtccaaacgc catttttatc ggaaagcaat 153720 tcagtaagat ataaaataag catagcgggt tcttgcccgc tttctacagc aggaccatat 153780 gtcaaatttc aggataatcc tatcggaagt caaacattta acgcaggtct tcatttaaga 153840 gtttttgacc cttctacggg agcattagtt gatagtaagt catatgcttt ttcggcttca 153900 aatgatacta catcagctgc ttttgttagt ttcatgaact ctttgacgaa taatagactt 153960 gttgctatat taactagcgg aaaggttaat tttcctcctg aggtagtatc ttggctaaga 154020 gccacaggaa cgtctgcttt tccatctgat tctatattgt caagatttga cgtatcatat 154080 gctgcttttt acacttcttc taaaagagct attgcattag aacatgttaa actaagtaat 154140 agaaaaagca cagatgacta tcaaactatt ttagatgttg tatttgacag tttagaagac 154200 gttggagcta cgggatttcc taaaagaaca tatgaaagcg ttgagcaatt tatgtcagcg 154260 gttggtggaa ctaataacga aattgcacgt ttgccaactt catccgcgat aagtaaactc 154320 tctgattata atttaattcc tggcgatgtt ctttatctta aagcacagtt atatgctgat 154380 gccgatttac ttgcgcttgg aactacaaat atatctatcc gtttttatga tgaatcgaat 154440 ggatatattt cttcaacaca tgccgagttt accggacaag ctgggtcatg ggaattaaag 154500 gaagattatg tagttattcc agaaaacgca gtaggattta cgatatatgc acaaagaact 154560 gctcaagctg gtcaaggcgg catgagaaat ttaagctttt ctgaagtatc aagaaatggt 154620 ggaatttcaa aacctgctga atttggcgtc aatggtattc gagttaatta tgtctgtgaa 154680 tctgcttcac ctccggatat aatggtactt cctacgcaag catcgtctaa aactggtaaa 154740 gtgtttggac aagaatttag agaagtttaa attgagggag ccttcgggtt ccctttttct 154800 ttataaatac tattaaaata aaggggcata caatggctga tttaaaagta ggttcaacaa 154860 ctggaggctc tgtcatttgg catcaaggaa attttccatt gaatccagcc ggtgacgatg 154920 tactctataa atcatttaaa atatattcag aatacaataa accacaagct gctgataacg 154980 atttcgtttc taaagctaat ggtggtacat atttaaataa agtaattttt aataaaggaa 155040 tgactgttcc tggtgcaggg tcaggtgaca atggtatttt tgctggtcct ggtgatagtg 155100 ccacgtatga tactacaaat atggatattg tttcgtggta tggtgttggt tttaaatcat 155160 cacaaggaac agcaggtaga actgtagtaa ttaacacacg aaatggagat attagctcaa 155220 agggcgtaat tgaagcatca caaatccgtg taacttcgtt atcaccagta aataattatg 155280 accttacgcg gaaagattat gttgatggag caataaatat tgttacagca aacgcaaact 155340 ctagggtatt acgctctgga gacactatga taggaaattt aactgcgcca aacctttttt 155400 cacagaatcc tgcatctcaa ccctcgcatg ttccacgatt tgaccaaatt gttattaagg 155460 attctgttca agatttcggc tattattaag aggacttatg gctactttaa aacaaataca 155520 atttaaaaga agcaaaactg caggagcacg tcctgccgct tcagtattag ccgaaggtga 155580 attggctata aacttaaaag accgtgtact ttttactaaa gatgaccaag gaaatattat 155640 tgatctgggt tttgctaaag gcggtagtat tgacgggaat gttattcata caggcaatta 155700 taaccaaact ggcgattata ctttaaatgg tgtcttcact cagactggta attttaattt 155760 aactggtatt gctcgagtaa ctcgcgatat tattgccgct gggcagatta tgactgaagg 155820 cggagaactt attacaaaaa gttcaggtac agcgcatgtt cgttttttcg ataacaatag 155880 tcgcgaacgc ggaatcattt atgccccggc taatgatggt ttaactacac aagtacttaa 155940 tatcagggtt caagactacg ccgctggtag cgaaagcact tatgcatttt caggcagtgg 156000 actatttact tcacctgaag tatcagcatg gaaatctatt tcgtctccac aaattctaac 156060 caacaaagtc attactaata ataaatctac gggtgattat gacatctatt cgatggcaga 156120 caatgttcca ttgtctgaaa gcactactgc tattaatcat cttcgtgtca tgcgtaatgc 156180 cgttggttct ggtattttcc atgaagttaa agataatgat ggaataactt ggtatgcagg 156240 tgatggactt gacacctatc tttggtcatt tacttggagc ggcggaatta aatcgagtca 156300 ctcaatttct attggtttaa cacctggtaa taaagattat tcaatattag gaccatctag 156360 tattgcttta ggagataatg atactggatt taaatggcat caagatggat attattttag 156420 cgttaataat ggaacaaaaa cgtttttatt tagtcctagc gaaacaacta gcctaagaaa 156480 atttgtagct ggatattcta ctaacggaac cgatttaact actcctccaa ctgaaaacta 156540 tgctctcgct actgtcgtga catatcacga taataacgcg tttggagatg gtcagactct 156600 tttaggatat tatcaaggcg gtaactatca tcattatttc cgcggcaagg gtaccacaaa 156660 cattaatact catggcggtt tgttagttac tccaggtaat attgatgtta ttggcggttc 156720 tgttaatata gatggtagaa ataattcttc tacactaatg tttagaggca acacaacagg 156780 atacagctcg gttgataata tggatattaa agtttggggt aatacgtttg ttgacccaag 156840 cggaggtatc cgtaaaaaca ttatggaaat ttctgatgca actagctgga tgagctatat 156900 tcaaagactt actactggcg aagtagaaat gaacgttaat ggttcatttg aatcatctgg 156960 tgttactgct ggagatagag gagttcacac aacaggtgaa atttcatctg gggctgtgaa 157020 tgcgcttcgt atttggaacg cagattatgg agctattttt agacgttcag aaggcagtct 157080 tcatattatt ccaactgctt acggtgaagg taaacatggt gatatcggtc cacttcgccc 157140 gtttagtatg gctttagata ccggtaaagt tactattcca gatttacaat caagttacaa 157200 tacgtttgct gctaacggtt atattaaatt tgttggtcat ggagcgggtg ccggcggtta 157260 tgacattcaa tatgctcaag cggctcctat tttccaggaa attgatgatg atgctgtaag 157320 caaatattat cctattgtta aacagaagtt tttaaatggt aaagctgttt ggtctttagg 157380 tactgaaatt agttcaggta cattcgttat tcatcatctg aaagaagatg gttcacaagg 157440 ccatacgtct cgttttaatc aagacggtac tgttaacttc ccagataacg tttctgtcgg 157500 cggcggtgaa gctactattg ctcgcaatgg taatatctgg tctgatatct ggaaaacgtt 157560 tacttcagca ggcgacgtaa ctaatattca cgatgcaata gctactcgtg ttgctaaaga 157620 aggtgatacg atgaccggta ggttgacttt atctgctgga aatgatgccc ttgttttaac 157680 tgcaggcacg ggcgcttcat cgcacatccg tagtgatgta ggtggtacaa ataattggtt 157740 tataggcaaa ggcggcggcg acaatggtct aagtttttac agttacatta cacaaggcgg 157800 tgtgaacata acaaataacg gcgaaatagc gctttctcct caaggacaag gagcgtttaa 157860 ttttaataga gaccgccttc atataaacgg tacacaatgg accgcacacc aggctggcga 157920 ttggggaaat caatggcgcc aggaagctcc tgtatttgtg gattttggta atgtcggtaa 157980 tgatagttat tatcctatta ttaaaggaaa atctggtatt actaatgaag ggtatatatc 158040 tggtgtagat tttggtatgc gacgcattcc taataactgg gcacaaggta ttattcgtgt 158100 aggtaatcag gaaaacggtt ccgacccaca agctatcttc gaattccacc ataatggaag 158160 catgtacgtt cctgacatgg ttaaagctgg agtaagaata tcagctggtg gaggtgaccc 158220 tgcatggaca ggcgcatgtg ttgttattgg tgataatgac accggattag ttcatggtgg 158280 tgacggccga atcaatatgg ttgccaatgg tatacatatt gcaaactggg gagcaggcta 158340 tcaatctcat cctgggcttt gggattcaac cggtgctttt tggacagaag ttggaagagc 158400 tatcgtttct catgggcatc tcgttcaggc aaatgatagt tattcaacgt ttgtccgtga 158460 tgtttatgtc cgttctgata ttcgtgttaa aaaagacctt gttaaatttg aaaatgcttc 158520 tgagaagctt tctaaaatta acggttacac ttatatgcag aagcgaggcc tagatgaaga 158580 aggtaatcag aaatgggaac ctaacgccgg tttgatagct caagaagttc aagctatttt 158640 gcctgaatta gttgaaggtg accctgatgg cgaagcttta cttcgtttga actataacgg 158700 tgtaattggt ttaaatacag ctgcaatcaa tgagcatact gcagaaattg cggaacttaa 158760 atcagaaatt gaagaactta aagcattagt taaatcattg ttaaaataat aagaggggct 158820 tcggcccctt ggaggtttat atggcagtaa caggaccgtg ggtaggatcg tctgcagtag 158880 ttaatacagg acaaaattgg atgggtggtg ccgcgcagag attgagaatg ggaattccgt 158940 tttggatgag taatatgata ggtcgatctg ttgaaataat tcacacgctt ggagcagacc 159000 ataacttcaa tggtcaatgg ttccgagata gatgttttga ggcaggtagt gcacctatag 159060 tgtttaatat tactggagat ttagtatcat attctagaga tgttccttta ttcttcatgt 159120 acggagatac acctaatgaa tacgttcaac tgaacataca cggcgtaacg atgtatggtc 159180 gtggtgggaa tggttgggcc gctggtgcaa ttggagcatc tgatggcggt gtatgtatcc 159240 agaatgatat aggtggacgt ctgcgaatta ataatggcgg agctattgcc ggtggcggcg 159300 gtggcggcgg tggttattca caagccaaca actgggcggg aaaatatgtt tgtggtggcg 159360 gtggcggtcg tccattcggc ttaggcggaa ataatggtgc tcgatggcct ggtggtaatg 159420 ctagtttgg gtctccgggt gccggcggta atactggtac agggtattat gcaggtggcg 159480 gtggtgaagt tggtcagcca ggacaatatg ctaatccagg tgctggttat tcaacacctc 159540 cgacaagtcc tggtgctgct gtagcaggat cagctccaac atggcagaat gttggagcaa 159600 tatatggttc aagagtataa tttgaataaa tatccttaaa aggagggtct atggcagcac 159660 ctagaatatc attttcgccc tctgatattc tgttgggtgt tctagatcgc ttgttcaaag 159720 ataacgctac cgggaaggtt cttgcttccc gagtagctgt cgtaattctt ttatttatga 159780 tggcgattgt ttggtatagg ggagatagtt tctttgagta ctataagcaa tcaaagtatg 159840 aaacatacaga tgaaattatt gaaaaggaaa gaaatgcacg ctttgaatct gtcgccctgg 159900 aacaactcca gatagttcat atatcatctg aggcagactt tagtgcggtg tattctttcc 159960 gccctaaaaa cttaaactat tttgttgata ttatagcata tgaaggaaaa ttaccttcaa 160020 caataagtga aaaatcactt ggaggatatc ctgttgataa aactatggat gaatatgcag 160080 ttcatttaaa tggacgtcat tattattcca actcaaaatt tgctttttta ccaactaaaa 160140 agcctactcc cgaaataaac tacatgtaca gttgtccata ttttaatttg gataatatct 160200 atgctggaac gataaccatg tactggtata gaaatgatca tataagtaat gaccgccttg 160260 aatcaatatg tgctcaggcg gccagaatat taggaagggc taaataatta tttgttcgta 160320 tacatctcta gatatcgata tacaccctca aaaccctcgt tgaattcgtc gatgagggtt 160380 ttcttatctt cctgagttaa ttcagaaaca attttacgga atgaattctg atttaacttt 160440 ctaccttcat gcgttactcc aatctcattc agaaatgcaa taaaattagc acgattttca 160500 acaatatctt ctctggaaaa tttaatcaaa atagacgcaa cagtaataat ttcacgaact 160560 gtatcaatgt ttttattcat taactatacc actcaattag ttgactttgt tataatatca 160620 tcagacgctt gatttgtaaa ctggtctgtg ttattttctt caaaaatttt ttctacgaat 160680 tccttgaacg actcacgttc ctgagctgca ttatgctcga ttaccttttc aagattatga 160740 ctcattcgaa ataatcttca atttcgtaat catggacgta aatcattata gtttttaata 160800 catcatcaat actttttcct ggagctggaa ttacgtaaaa atatcctgct tttgggaggt 160860 ctttataagt tccaattaag aaatcattat tctcaagatg cagttcttca actaattcat 160920 cgacaattga gtggtataaa tttggtagaa acttatatag cttttctaga atgtcaattt 160980 tgattgtata ttgaaccaca gattgagaat caataatcat agaccttccc cttatgtttc 161040 tgtttgcgat tagattcttt aaacgctttc ttcttatctt tatgaacaga agctttatta 161100 aaattatgtt ttgcgactaa attgttcata gtgctgaatt acctctctta aacatttgca 161160 tgtgaatgaa aactttttag ctacaccaca ttcaaatata tgttctctta aatcacgtgt 161220 gtcagtatat cccatctcaa caataaaatg ccgtattaga tttttatctt tatcattgag 161280 agagttaaaa taatcggatt ttgaattaat ttccctggcc aaattgaatc acctccagtt 161340 gacgttttag ctcttttatc atctcttcat tcatcgcaat ataaagatcg cgtaaagcag 161400 gttttaacat tccatttatt ggagaactaa atgggcatac ataatctttt cctacgagct 161460 ttttagtgaa ttccatatca caaaactgaa atgcaggttc attagcataa attccccaat 161520 tagttgacat cattttattg gcatattcta atgcctggat ttgattagta attccatcaa 161580 tttgaaactt tttaatattc attagtaaag gtcctcagag taaagttctt tttcactacc 161640 accacgttca atacgtactt gtccagcgta agttgcaata atcattgctt cttcacgtgt 161700 ccaataatta ctatattggt caataaaccc ttgatcatca tcacaaactt gctgagtaac 161760 taattgaggt ttaactacat ctaaaactgc tgccatatct ttagaataat gacgagcacc 161820 cggaataata agagttcgtc catcttttaa tttaaaacgg ttggctgcgc aaacaattcg 161880 tcgttgatac ttttggtttt catcccagta tgcggtttgc caacagattt caggaacttc 161940 tgcaagaata tcttcttctg tgcatttata accatgcgct ttaaattttt gaacaagact 162000 ttctggagtc tcacgagata aaggaacatt cagcattttt aaacgattaa taaatggatt 162060 catttaaacc atcctttaat acgttgccac aaagttttct gttgagcttt gttaacacca 162120 attgagcgaa taactggttg agattcctgg aattctttat aatcagcaag gtaaatttcg 162180 taagctgaat ccgtaaagga acttatagct gccatgaaat tattgcgaat acccactgga 162240 gcatctttac tttcacgaat aatcatgtat ttgccagtct taatctttac aatagttcca 162300 agataagccc catggtacca gatgtcccac ccctcttgag taggttctgc gcaacgacga 162360 agttcattaa caatttctaa cttgttcatt atttattcct cacagttcag atgctacggt 162420 gattacagct tcaatgtttt ctgctgagcg tttaatgtca agatacacat taccattttt 162480 agcgatttta catgacatac cgatatcagt aaatttctga atatgatgtt ccatcatttt 162540 gtatccaaaa attcgcatat ttccattgtt gttaatttca aaattacgaa ttccgtgagt 162600 gcgtttttct aaaatagcga gatagttact acgataagtt tcaacctttt taagaacaaa 162660 tccattttca tctaaaagtt ttaacatgaa gtctttatct tcttccatat cagaagtaat 162720 ctcgcgagct ttacgagttg ctcgtttttt cagcagttcc ggagcgtttt cctgtgcgta 162780 taaagttgct gcatttgaaa taatatcctg agcttcacca gtaatgatta atccatcacc 162840 agatttctct accaggcctt ttttaatcaa taccccaata ttactattaa ctactgcatt 162900 acctaaatct ggatgcacct cacgaacttc tgcagctgta atgaaatctt tcttagcaat 162960 agtaattaaa atcgcagcag ttttttcatt cagaatatcg ttagaagctt tgatgatgta 163020 agttacttta gacattttct aatctccgta attctgtatc agtagttgat agttgtatag 163080 taccacagta tgctttggtt gtaaaccgtt ttgtgaaaaa aatttaaaat aaaaaaggga 163140 gagcctcggc tctccctaaa attactgcat gacagttatc acagtcatga taacacgttg 163200 aatgccgaac gcaagaagac ctcccgctac agctggaaca acacctagac ccgctagtaa 163260 aatgctacca gatactaatg cagcgcttgt aataccaatg aatggactca tttgatttcc 163320 tctaaatctt tggtgtattc tgtaactaca tcagtagttt tccaatattc gttttcttct 163380 tttttagctt tagcttcttc agcaagtttc tttgcttcgt cggaagtcat atgaaaaata 163440 ttcattccga ctagtttatc aacataagaa gaatacatat caattttaga aagttcttcg 163500 gtcagttctt tgcgagtttt accctgcaca acaatttcac ctgaaattac tttcttaatg 163560 aaatgtgcct tggcaaaggc taaacgaaat gctgattcag tttctttgat tttgttatca 163620 attcgttttt ggacataagt tttacgaact tcaacaaagt ctttaattaa atcaactacg 163680 ttatcgtaaa cttgtagctt tcctttctca ttaatgactg taatattctg agaacgacgc 163740 tcaatcaacc caaagtcttt cataattttt gcatgacgtt cttcttcgtt atcactcaaa 163800 gagtattctt tgcggaattt aactttaaag ccaaagccat gctcaccgca agcatcatcc 163860 catgtaatga agcctttatc ttcaagcggg tctaagattt tactcacgta agtttcacga 163920 tcatacttat acggaatctc agtgatattc atttgagttc gtgaagtaaa cttatatgtt 163980 ccacgaattt catattgccc gtcaatctca acgacttcac cgcgaaattc tgggaattct 164040 actttcggtt tagttacttt ctttccttga agagcttgta atacagcttt cttaacagaa 164100 gaaacactat gaggaagaat gtaagttgca taaccagttg caataccgga aacaccatta 164160 agaagaacag taggaataat aggcaaatag aaagcaggag gaatgtgttc tttatcttga 164220 tgtaccggag catattcagt atctttatat acgttataga aatttttact tacacgagca 164280 aaaatataac gacttgccgc tgctttttga acagtacgag aaccaaagtt tccttgacca 164340 tctaacaaag gaaagttatt attccatgta ttagccatca aagcccccgc atcttgtgca 164400 gagttttcac cgtggtgata cccaaggtca gctacaccac ctgcaataga agcaagtttg 164460 tgaaacttat ctttatttcc ccgtgccaaa tcaagagctc gagcgataac aaatcgttga 164520 actggcttaa atccatcaat catatttggg atagcacgat tttcaaccgt gtacatagca 164580 taagccaatg cttcattatc aatgatactt tttaaatcgc gattattcag ttgcataaat 164640 ttaccatact agtgaatgta gtgccataat aacatcagaa atgaaaagca cgacttgaat 164700 taatccgaac attactccat aatatagtgc taccaataaa gcagcaaggg ctactgagta 164760 gcccaagatt ttcttaatca ttagtagata acaacacaaa tgttaaatat gcacacatac 164820 cctgggctaa agcttgtgaa aacacactgc tagcatcaat acaaatagtt aaaacacatg 164880 ctactatcca acaaataaat gaaataactc ctaataattt tgcaatattc atattttcct 164940 cactagcgtc cgaagatgcc tttagtttta agattgttac gatagaactg cattacatgt 165000 tcgttatgga aattactcat tagtatgcct gcaaaacaaa tttaaagtta tcagccaaca 165060 tacgattcat ttcttcaagc gtttgatact cagaatgatg attacgagta aacgctaaag 165120 ctaactgacc ttttccaaat cccgtcgtca gaggtttcat cttagaagca ggtagataaa 165180 atactgtgta tggaacattg ttatttgcaa tagtacgcgc aagctgagac cgacgctggc 165240 gaatatgact tagaactgca ctgaatcctt gcttagaacg ctgattacct acataaaatc 165300 gtgcagatac gcatcgacta ccaaatggac gaccatctaa tttactcgct aaaaagtaaa 165360 atccagggtt agacaaaatg tctttatgtg gagttccaaa aacccattca ccgcccttga 165420 ttgtaccaat aacagttgcg cctgcattat tcaaatcagt aacagtcata tatttcatgt 165480 taatttcctc taattatttt ctactccaag gccgcatgaa tacacacggc cgataaatta 165540 atcgtcgcag tcgacgctca attcccagaa ctcttctaca gtataagttt cagtatcatt 165600 ttcaatacag aaacgttcat tactgttatt tgctaaagta gcgttaactg tcattttctc 165660 gctggtgctc ttaagaggcg aaatacgaat taactgatca ccattatcta agcaaaaaat 165720 ttcgccaact tttacatctt taaaaatttt cataattcac ctcaaggagt ataaaatcca 165780 aatgcagttg ttgaccatcc catccaatat gggggatatt tgcgccaatg taaaatacaa 165840 gaatataaaa ccaaatgctt agtaaattca ttattttaca ccattccaaa ttgtttcaac 165900 cacagatttt aaaccatttt ggtgaatatc cattccgaca accgccatca aatagattcc 165960 aaccacaact gaacccaagg caaaaatcag catgaaaatg aataaagctg gaaaaatatt 166020 atcgaaaaac cattccataa atgtaaaagc actacgttta cgcttcatat tttcctcaca 166080 taaatccaaa gtaagcgttt aatacatcaa tcattaaaac gattgggaat atactcaaaa 166140 ctactagtat tataactaca ttccatatag ctttaacaat ctttttcatt ttctgttcct 166200 ccgtagttga tagagtaata ataccacaga ggaacagtct tgtaaacaac ttttttaaaa 166260 atattcgtaa taaatgtgaa taccaatcac tactgccgaa acttgcgcaa cccaccacgc 166320 acaagcaata agtacagaat ttaaaatttt cataataacc tcatcacaaa agtaaatgtt 166380 aaacaaatta atggaatact aattaaccaa acaaaacacc accataatga actcatagtt 166440 caatctcagc gattttcatt tcattactat taatagccgc tttaagacta tctgaaagaa 166500 ttacattcca gtggtcattc atatgaccat taactaagcg tgtaatttct tcgggagttg 166560 aaaaataagg cgtatcagac tcccaatgcg atagtcccaa gcgagtataa atcatacctt 166620 catcgtcgct agaatattca actgacacaa actcatcagt tattttatgt ttagcgtaat 166680 aaaatttaaa tttcattttc cgctcctccg tagttgatag ttgtatagta ccacggtcct 166740 tgtggtatgt aaaccgtttt gtgaaaattt ttaaatggaa agataccatc cattgtagtt 166800 gctttttctt acaaccttac gaaggtcttc tctgtcaccg atgaacttcg gagtgtactg 166860 gatgacacct ggatgaattt ctttagtgtt gaatataatt atacagtcag cgacttgatg 166920 attcagaatg ggccctagat ttattccaga accgtatgga tactctccgc tgcatccggt 166980 tgttaccgaa atccaacgtg agtcagtttg atgtgtctta acttctacac gaagcccgca 167040 gtatcttgga tgcgccaata catcccatgc atatgtatac gggtcatcga catcttcttg 167100 acctttgtta acatacccgc tcagccaatc tgctacaaaa aactctgcgt acacagcgat 167160 acggcatctt tcgataactt ctgccttatc ctgattcgga ttttgtttta aagagtatct 167220 tgctgtatca gcaattttga ccttcatttc actagtcaag tcaccgttcg atagggtaaa 167280 tgtcggaatc tgaaatagtc tctgtaaacc cggattcgtt ttctgcattt agactttcct 167340 ttttaccact gagataagcg ttatatactt taagagtgcc gtaataaatt cggtcatttt 167400 catctaaaga ctcgcggtca agttcatcga gctccttttt atccatgact ataacatcat 167460 tacagtaaag aaacccaagt ttttcgtgac caaactcaaa tttattacaga tacacaatat 167520 tagcgtgatg atttccgtgc agtttaatct cttttatatc ggaatcaccg atattcatac 167580 aataaatcat aatttttcct taaaacaaaa gggccgaagc cctttatttt acttgaattg 167640 tgcaattctt ttctctagac attcagcata agatttcatt gagataaact gtgaaagtaa 167700 cagttcttgc tcaactgcac taactgttag aaactttgcg ctttctaaaa atttactcag 167760 tgcattaatt ttgagcatta attgatcgta ttcttctttt actcgtgctt gataacctaa 167820 cataattttc cttaatgtga taagggccga agcccttatt taaattgttc agtaacgtct 167880 tcaactactt cgtattggca ggtacgcatt ttagcatcgt tgtaatcaat cggaattgat 167940 actacatcgc gaggatgaac tttaactttt acaactcggc tggttgaact gccaaagtga 168000 cgaatataag atttagaaca cacatgcaga ccgcgagaac aagtttgcgt atcatcgtca 168060 ttcacacgag tacgtggcat tttaactact ttaccaggac tgttatcaaa ggtatttgag 168120 tgacaatcaa agtaattgct gcgaactact ttccaagcat agaagtaacc atcttctgta 168180 atttcaatat cgtttgctac caagaaatca aagagtcgag aaaccgcttt ctggcttggg 168240 ttttccagca gattttccaa gaacggaaaa taaaattcaa agttttcgcc tttttccatc 168300 gaatcaagaa tacgatcaac caaaccagac cgcaattcaa tattttgata gaacaagctt 168360 ccaccttcaa ttcgaacatc gccggaaata tatttttcaa cagcgcgacg aacattaatt 168420 ttttgtgctg cttcttctaa cttatctgct acaagcagat taagaatttc ctggaagttt 168480 gaatgagtat taggagttgc gttataagtt acgccatcaa cagtaattga aatgaatttt 168540 ttagatgcat tccaaataat gtcagattta gcaactggag caatagctgt atcgctatca 168600 actttaaccg taatgtcacc gctaatagta actttaggac gtttagcttc ttcagcattt 168660 ttcaaaacac gacggattgt gtcaaccgat acatccttcc aataagctaa ttcctgctgg 168720 gtgtaattac cgcttgaata cagtttgaca atttcagctt gttcgttttt ggtcaggcat 168780 ttaatattgt acataatttt cctta 168805

Claims (12)

시가독소 생성 대장균(Shigatoxin producing E. coli, STEC)에 특이적인 사멸능을 갖는, 서열번호 1로 표시되는 염기서열로 이루어진 박테리오파지 EC121 (기탁번호 KFCC11691P).
Bacteriophage EC121 (Accession No. KFCC11691P) consisting of the nucleotide sequence shown in SEQ ID NO: 1, which has a killing activity specific to Shigatoxin producing E. coli (STEC).
삭제delete 삭제delete 제1항에 있어서, 상기 시가독소 생성 대장균은 ESBL(Extended Spectrum β-lactamase) 생성 대장균인, 박테리오파지 EC121.
The method according to claim 1, wherein the cytotoxin-producing Escherichia coli is ESBL (Extended Spectrum β-lactamase) -generating Escherichia coli bacteriophage EC121.
삭제delete 삭제delete 제1항의 박테리오파지 EC121을 포함하는, 항생용 조성물.
An antibiotic composition comprising the bacteriophage EC121 of claim 1.
제1항의 박테리오파지 EC121을 포함하는, 사료 첨가용 조성물.
A composition for feed addition comprising the bacteriophage EC121 of claim 1.
제8항의 사료 첨가용 조성물을 포함하는, 사료.
A feed comprising the feed additive composition of claim 8.
제1항의 박테리오파지 EC121을 포함하는, 소독제.
A disinfectant comprising bacteriophage EC121 of claim 1.
제1항의 박테리오파지 EC121을 포함하는, 세척제.
A cleansing agent comprising the bacteriophage EC121 of claim 1.
제1항의 박테리오파지 EC121을 인간을 제외한 개체에 투여하는 단계를 포함하는, 시가독소 생성 대장균(Shigatoxin producing E. coli, STEC)에 의한 감염성 질병의 예방 또는 치료 방법.A method for preventing or treating infectious diseases caused by Shigatoxin producing E. coli (STEC), comprising the step of administering the bacteriophage EC121 of claim 1 to a subject other than a human.
KR1020160178107A 2016-12-23 2016-12-23 Novel pathogenic Escherichia coli specific bacteriophage EC121 and antibacterial composition comprising the same KR101871347B1 (en)

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Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009037264A2 (en) 2007-09-17 2009-03-26 Da Volterra Colonic delivery of antimicrobial agents

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009037264A2 (en) 2007-09-17 2009-03-26 Da Volterra Colonic delivery of antimicrobial agents

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
GenBank: JN986846.1, 2012.11.01.*
Viruses. 2012, vol. 4, pp. 471-487.*

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