KR101845639B1 - Composition for Anti-Allergy Using an Extract of Amsonia elliptica - Google Patents
Composition for Anti-Allergy Using an Extract of Amsonia elliptica Download PDFInfo
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- KR101845639B1 KR101845639B1 KR1020160166448A KR20160166448A KR101845639B1 KR 101845639 B1 KR101845639 B1 KR 101845639B1 KR 1020160166448 A KR1020160166448 A KR 1020160166448A KR 20160166448 A KR20160166448 A KR 20160166448A KR 101845639 B1 KR101845639 B1 KR 101845639B1
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Abstract
Description
본 발명은 정향풀(Amsonia elliptica) 추출물을 이용한 항알러지용 조성물에 관한 것이다.The present invention relates to an amphiprotic elliptica ) extract of the present invention.
알러지(Allergy)는 그리스어의 '변한다'는 의미의 'allos'와 '작용'의 의미인 'ergo'가 결합되어 생성된 합성어로 생체 이상 반응의 뜻을 가지고 있다. 어원이 이러하듯, 알러지는 보통 사람에게는 아무런 반응도 나타내지 않은 물질인 알러지원(allergen)이 선천적 또는 후천적 면역기능의 이상으로 특정 사람에는 두드러기, 가려움, 콧물, 기침 등의 과민반응을 일으키는 것을 말한다. 전형적인 알러지원은 꽃가루, 약물, 식물성 섬유, 세균, 곰팡이, 집먼지진드기, 음식물(난알부민, 우유단백질, 땅콩), 염색약, 화학 물질 등이 있으며, 최근 실내 생활의 증가, 신소재 화학물질 등과 같은 알레르기 유발 물질의 증가, 환경오염, 스트레스로 인한 면역기능 저하, 그리고 식생활의 변화 등으로 이러한 알러지 질환은 전세계적으로 증가하고 있는 추세이다. Allergy (Allergy) is a combination of 'allos' meaning 'change' in Greek and 'ergo' meaning 'action'. As the etymology shows, allergies are allergens, which are substances that do not respond to common people, cause irritable reactions such as urticaria, itching, runny nose, cough, etc. in certain people due to inherited or acquired immune function abnormality. Typical allergenic circles include pollen, medicines, vegetable fibers, bacteria, fungi, house dust mite, food (egg albumin, milk protein, peanut), dye and chemicals. These allergic diseases are increasing worldwide due to increased substances, environmental pollution, decreased immunity due to stress, and changes in diet.
알러지 반응은 Ⅰ형 anaphylaxis형, Ⅱ형 세포용해형, Ⅲ형 면역복합체형, Ⅳ형 세포중개형, Ⅴ형 자극성 과민반응형의 5가지 유형으로 분류되는데, 대부분은 제Ⅰ형에 속하며, 일반적으로 알러지 반응이라 하면 제Ⅰ형과 동일한 의미로 사용된다(Roitt I, Brostoff J, Male D. Immunology 6th eds. U.S.A.. Mosby. 2001:323-383). Allergic reactions are classified into five types: type Ⅰ anaphylaxis type, type Ⅱ cell type, type Ⅲ immunocomplex type, type Ⅳ type cell mediated type and type Ⅴ type irritable hypersensitivity type. Most of them belong to type Ⅰ, Allergic reactions are used in the same sense as Form I (Roitt I, Brostoff J, Male D. Immunology 6th eds USA, Mosby 2001: 323-383).
대표적인 알러지 질환으로는 아토피성 피부염, 기관지 천식, 알러지성 비염, 알러지성 각막염, 피부 두드러기 등이 있으며, 이들 알러지 질환에는 비만세포(mast cell)가 중요한 작동세포로 알려져 있다(Wills-Karp M., et al., Science, 282:2258-61, 1998; Grunig G., et al., Science, 282:2261-2263, 1998). 비만세포는 피부, 호흡기, 림프관 주위, 위장관의 점막, 혈관 주위, 뇌 등 전신의 장기에 널리 분포하고 있는 세포이다(Ishizaka t., et al. J. Immunol. 119:1589, 1997).Major allergic diseases include atopic dermatitis, bronchial asthma, allergic rhinitis, allergic keratitis, and skin rash. Mast cells are known to be important working cells in these allergic diseases (Wills-Karp M., et al., Science, 282: 2258-61, 1998; Grunig G., et al., Science, 282: 2261-2263, 1998). Mast cells are widely distributed in the organs of the body, including skin, respiratory system, lymphatic vessels, mucous membranes of the gastrointestinal tract, blood vessels and the brain (Ishizaka et al., J. Immunol. 119: 1589, 1997).
알러지 반응은 이러한 비만세포 표면의 IgE 고친화성 수용체 (FcεRI)에 결합되어 있는 IgE에 알러지원이 결합할 때 세포내 신호전달경로의 활성화를 통해 유도된다. 구체적으로 알러지원이 생체에 침입하면 T-조력세포(T-helper cell)와 B 세포가 순차적으로 활성화되어 IgE가 생성된다. 생체에 침입한 알러지원은 항원제시세포에 의해 인지되며, 이 항원제시세포는 알러지원 제시를 통해 Th0(T helper cell type 0)를 Th2 세포로 분화시킨다. 이렇게 분화된 Th2 세포는 IL-4, IL-5 및 IL-13과 같은 사이토카인을 분비하며, 이들은 골수에서의 산성백혈구 발달을 촉진시켜 염증이 발생한 조직으로 산성백혈구를 유도할 뿐만 아니라, B세포에 작용하여 IgE 및 IgG1의 생성을 유도한다.The allergic response is induced through the activation of intracellular signaling pathways when allergen binds to IgE bound to the IgE high affinity receptor (FcεRI) on the surface of these mast cells. Specifically, when the allergen enters the living body, T-helper cells and B cells are sequentially activated to produce IgE. The allergen entering the living body is recognized by the antigen presenting cell, and the antigen presenting cell differentiates Th0 (T helper cell type 0) into Th2 cell through allergen source presentation. These differentiated Th2 cells secrete cytokines such as IL-4, IL-5 and IL-13, which stimulate acidic white blood cell development in the bone marrow to induce acidic leukocytes as inflammatory tissue, To induce IgE and IgG1 production.
이렇게 생성된 IgE는 비만세포막의 고친화성 IgE 수용체(FcRIα)에 결합하고 여기에 진드기, 꽃가루 등의 알러지원이 결합하여 가교를 이루면 수용체 (FcRIα)가 응집한다. 수용체(FcRIα)의 가교 및 응집에 의하여 비만세포는 활성화되어 세포질 내의 칼슘이온(Ca++) 농도 등이 상승한다. 칼슘이온 농도의 상승은 세포막의 콜레스테롤이나 세포골격계 등 여러 종류의 세포 내 조절인자에 작용하여 과립을 세포막에 이동시킴과 동시에 과립의 공포화, 과립 상호의 융합 및 과립과 세포막의 융합 등을 거쳐 탈과립을 일으킨다. 탈과립이 되면 히스타민(histamine)과 같이 비만세포 내에 미리 저장되어 있는 화학전달물질(preformed mediator)이 유리됨과 동시에 새로 합성된 프로스타글란딘(prostaglandin), 류코트리엔(leukotriene) 등이 함께 분비된다. 탈과립으로 유리되는 화학전달물질에는 혈관확장, 혈관투과성 항진, 기관지 평활근의 수축이나 분비항진 등의 작용을 갖는 히스타민, 세로토닌(serotonin) 및 류코트리엔 이외에 호산구나 호중구등 염증 세포의 주화성 인자로 작용하는 NCF, ECF, PAF등이 있어서 알러지 반응이 일어나게 된다(Ennis M, et al., Br J Pharmacol 70:329-334, 1980; Metcalfe DD, et al., Crit Rev Immunol 3:23-74, 1981; Miyajima I, et al., J Clin Invest 99:901-914, 1997; Church MK, et al., J Allergy Clin Immunol 99:155-160, 1997; Jones DA, et al., J Biol Chem 268:9049-9054, 1993).The resulting IgE binds to the high affinity IgE receptor (FcRIα) of the mast cell membrane, and the allergic circle such as mites and pollen binds to the IgE receptor (FcRIα). Through the crosslinking and aggregation of the receptor (FcRIα), mast cells are activated and the calcium ion (Ca ++ ) concentration in the cytoplasm increases. The increase in calcium ion concentration acts on various kinds of intracellular regulators such as cholesterol and cytoskeleton of the cell membrane to move the granules to the cell membrane, and at the same time, the granules are released into the air, the granules are fused and the granules and cell membranes are fused, ≪ / RTI > When degranulation is achieved, a preformed mediator, such as histamine, pre-stored in mast cells is liberated and newly synthesized prostaglandins, leukotrienes, and the like are secreted together. In addition to histamine, serotonin, and leukotrienes, which act as vasodilators, vasoconstrictive agents, and bronchial smooth muscle contractions and secretion enhancement, the chemical messengers released by degranulation include NCF, which acts as a chemotactic factor for inflammatory cells such as eosinophils and neutrophils, , ECF, PAF, and the like, allergic reactions occur (Ennis M, et al., Br J Pharmacol 70: 329-334, 1980; Metcalfe DD, et al., Crit Rev Immunol 3: 23-74, 1981; Miyajima Jones et al., J Biol Chem 268: 9049-914, 1997; Church MK, et al., J Allergy Clin Immunol 99: 155-160,1997; 9054, 1993).
사이클로옥시게나제(cyclooxygenase, COX)와 리폭시게나제(lipoxygenase, LO)는 아라키돈산(arachidonic acid)으로부터 알러지 증상 유발 물질인 프로스타글란딘류와 류코트리엔류를 만들어내는 과정의 일부를 촉매한다고 알려져 있다(Sekiya K, et al., Biochem Biophys Acta 713:68-72, 1982)Cyclooxygenase (COX) and lipoxygenase (LO) are known to catalyze a part of the process of producing allogical symptom-inducing prostaglandins and leukotrienes from arachidonic acid (Sekiya K , et al., Biochem Biophys Acta 713: 68-72, 1982)
따라서 비만세포의 활성화를 억제하거나, 히스타민 방출을 억제하거나 프로스타글란딘류와 류코트리엔류의 합성을 억제하는 물질 등은 알러지의 유효한 치료약이 될 수 있다.Therefore, a substance that inhibits the activation of mast cells, inhibits histamine release, or inhibits the synthesis of prostaglandins and leukotrienes, can be an effective therapeutic drug for allergies.
현재 항알러지 약물로서는 항히스타민제(alkylamines, desloratadine 등), 비만세포 안정화제(cromoglycate 등), 류코트리엔 차단제(montelukast 등), 항-IgE 항체(Omalizumab) 등이 사용되고 있다. 그러나 이러한 약물은 그 효과가 일시적인 경우가 대부분이고 부작용이 심한 경우도 많다. 따라서 알러지 질환의 예방 및 개선효과를 가지면서 부작용이 적고 효과가 지속적인 새로운 물질의 개발이 여전히 필요하다고 할 수 있으며, 특히 천연물은 상대적으로 독성이 적은 장점을 가진다.At present, anti-allergic drugs are used such as alkylamines, desloratadine, mast cell stabilizer (cromoglycate etc.), leukotriene blockers (montelukast etc.) and anti-IgE antibodies (Omalizumab). However, these drugs often have a temporary effect and often have severe side effects. Therefore, it is necessary to develop a new substance which has the effect of prevention and improvement of allergic diseases and has a low side effect and a continuous effect. Especially, the natural product has a relatively low toxicity.
본 발명은 정향풀 추출물의 항알러지 활성을 개시한다.
[선행기술문헌]
명칭: 식물 추출물을 포함하는 진드기 알레르기원 중화제 및 이를포함하는 조성물
문헌번호: 한국 공개특허 제10-2007-0065927호
공개일자: 2007년06월27일The present invention discloses the anti-allergic activity of the extract of Clove grass.
[Prior Art Literature]
Name: Mite allergen neutralizer containing plant extracts and compositions comprising same
Document No.: Korean Patent Publication No. 10-2007-0065927
Published on June 27, 2007
본 발명의 목적은 정향풀 추출물을 이용한 항알러지용 조성물을 제공하는 데 있다.It is an object of the present invention to provide a composition for anti-allergy using an extract of Clover grass.
본 발명의 다른 목적이나 구체적인 목적은 이하에서 제시될 것이다.Other and further objects of the present invention will be described below.
본 발명은 아래의 실시예 및 실험예에서 확인되는 바와 같이, 정향풀 추출물이 IgE 및 항원(DNP-BSA)으로 활성화된 비만세포주 RBL-2H3(rat basophilic leukemia)에 처리될 때 탈과립을 억제함을 확인함으로써 완성된 것이다.The present invention inhibits degranulation when treated with an IgE and antigen (DNP-BSA) -activated mast cell line RBL-2H3 (rat basophilic leukemia), as demonstrated in the following Examples and Experimental Examples It is completed by confirmation.
전술한 바를 고려할 때, 본 발명은 정향풀 추출물을 유효성분으로 포함하는 항알러지용 조성물로 파악할 수 있다.In view of the above, the present invention can be understood as an antiallergic composition comprising an extract of clove extract as an active ingredient.
본 명세서에서, "정향풀 추출물"이란 추출 대상인 정향풀의 줄기, 잎, 열매, 꽃, 뿌리, 전초 등을 물, 탄소수 1 내지 4의 저급 알콜(메탄올, 에탄올, 부탄올 등), 메틸렌클로라이드, 에틸렌, 아세톤, 헥산, 에테르, 클로로포름, 에틸아세테이트, 부틸아세테이트, N,N-디메틸포름아미드(DMF), 디메틸설폭사이드(DMSO), 1,3-부틸렌글리콜, 프로필렌글리콜 또는 이들의 혼합 용매를 사용하여 침출하여 얻어진 추출물, 이산화탄소, 펜탄 등 초임계 추출 용매를 사용하여 얻어진 추출물 또는 그 추출물을 분획하여 얻어진 분획물을 의미하며, 추출 방법은 활성물질의 극성, 추출 정도, 보존 정도를 고려하여 냉침, 환류, 가온, 초음파 방사, 초임계 추출 등 임의의 방법을 적용할 수 있다. 분획된 추출물의 경우 추출물을 특정 용매에 현탁시킨 후 극성이 다른 용매와 혼합·정치시켜 얻은 분획물, 상기 조추출물을 실리카겔 등이 충진된 칼럼에 흡착시킨 후 소수성 용매, 친수성 용매 또는 이들의 혼합 용매를 이동상으로 하여 얻은 분획물을 포함하는 의미이다. 또한 상기 추출물의 의미에는 동결건조, 진공건조, 열풍건조, 분무건조 등의 방식으로 추출 용매가 제거된 농축된 액상의 추출물 또는 고형상의 추출물이 포함된다. 바람직하게는 추출용매로서 물, 에탄올 또는 이들의 혼합 용매를 사용하여 얻어진 추출물, 더 바람직하게는 추출용매로서 물과 에탄올의 혼합 용매를 사용하여 얻어진 추출물을 의미한다.In the present specification, the term "clove extract" refers to water, a lower alcohol having 1 to 4 carbon atoms (methanol, ethanol, butanol, etc.), methylene chloride, ethylene (DMF), dimethylsulfoxide (DMSO), 1,3-butylene glycol, propylene glycol, or a mixed solvent thereof is used as the organic solvent, for example, acetone, hexane, ether, chloroform, ethyl acetate, butyl acetate Extracts obtained by extracting with supercritical extraction solvents such as carbon dioxide and pentane or fractions obtained by fractionating the extracts, and the extraction method refers to a method of extracting the extracts obtained by extracting the extracts using a method of extracting the extracts using a method of extracting , Heating, ultrasonic irradiation, supercritical extraction, and the like can be applied. In the case of the fractionated extract, a fraction obtained by suspending the extract in a specific solvent and mixing and leaving with a solvent having a different polarity, the crude extract is adsorbed on a column packed with silica gel, and then a hydrophobic solvent, a hydrophilic solvent, Quot; means fractions obtained as a mobile phase. Also, the meaning of the extract includes a concentrated liquid extract or a solid extract in which the extraction solvent is removed by a method such as freeze drying, vacuum drying, hot air drying, spray drying and the like. Preferably an extract obtained by using water, ethanol or a mixed solvent thereof as an extraction solvent, and more preferably an extract obtained by using a mixed solvent of water and ethanol as an extraction solvent.
또 본 명세서에서 "유효성분"이란 단독으로 목적하는 활성을 나타내거나 또는 그 자체는 활성이 없는 담체와 함께 활성을 나타낼 수 있는 성분을 의미한다.In the present specification, the term " active ingredient "alone means an ingredient which exhibits the desired activity or which can exhibit activity together with a carrier which is not itself active.
또 본 명세서에서, "항알러지"는 아래에서 정의되는 알러지 질환의 개선(증상의 경감), 치료, 그러한 질환의 예방(발병 억제 또는 지연)을 포함하는 의미이다.In the present specification, the term "anti-allergy " is meant to include improvement (symptom relief), treatment, prevention (prevention or delay of onset) of an allergic disease as defined below.
또 본 명세서에서, "알러지 질환"은 비만세포의 탈과립 등 비만세포의 활성화가 매개된 알러지 반응으로 인하여 초래되는 병리적 증상을 의미하며, 이러한 알러지 질환에는 아토피 피부염(atopic dermatitis), 천식(asthma), 알러지성 비염(allergic rhinitis), 알러지성 결막염(allergic conjunctivitis), 알러지성 피부염(allergic dermatitis), 알러지성 접촉성 피부염(allergic contact dermatitis), 알러지성 각막염 등이 포함된다. In the present specification, the term "allergic disease" means a pathological symptom caused by an allergic reaction mediated by mast cell activation such as degranulation of mast cells. Such allergic diseases include atopic dermatitis, asthma, Allergic rhinitis, allergic conjunctivitis, allergic dermatitis, allergic contact dermatitis, allergic keratitis, and the like.
본 발명의 항알러지용 조성물에서 그 유효성분은 항알러지 활성을 나타낼 수 있는 한, 용도, 제형, 배합 목적 등에 따라 임의의 양(유효량)으로 포함될 수 있는데, 통상적인 유효량은 조성물 전체 중량을 기준으로 할 때 0.001 중량 % 내지 20.0 중량 % 범위 내에서 결정될 것이다. 여기서 "유효량"이란 항알러지 효과를 유도할 수 있는 유효성분의 양을 말한다. 이러한 유효량은 당업자의 통상의 능력 범위 내에서 실험적으로 결정될 수 있다. The active ingredient in the anti-allergy composition of the present invention may be contained in any amount (effective amount) as long as it can exhibit anti-allergic activity, depending on the purpose of use, formulation, compounding purpose and the like. By weight, and in the range of 0.001% by weight to 20.0% by weight. Here, "effective amount" refers to the amount of active ingredient capable of inducing an allergic effect. Such effective amounts can be determined experimentally within the ordinary skill of those skilled in the art.
본 발명의 조성물이 적용(처방)될 수 있는 대상은 포유동물 및 사람이며, 특히 사람인 경우가 바람직하다.The subject to which the composition of the present invention can be applied (prescription) is preferably a mammal and a person, particularly a human.
본 발명의 항알러지용 조성물은 유효성분 이외에, 항알러지 활성의 상승·보강을 위하여 이미 안전성이 검증되고 항알러지 활성을 갖는 것으로 공지된 임의의 화합물이나 천연 추출물을 추가로 포함할 수 있다. The composition for anti-allergy of the present invention may further contain, in addition to the active ingredient, any compound or natural extract known to have safety and anti-allergic activity for the purpose of raising or reinforcing the anti-allergic activity.
구체적으로 그러한 화합물 또는 추출물로서는 건강기능식품에관한법률에 따라 '과민 면역반응 완화' 기능성으로 개별인정을 받은 Enterococcus faecalis 가열 처리 건조 분말, 구아바 잎 추출물 등의 복합물, 다래 추출물, 소엽 추출물, 피카오프레토 분말 등의 복합물, PLAG(1-palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol)와, '과민 피부상태 개선' 기능성으로 개별인정을 받은 L. sakei Probio 65, 감마리놀렌산 함유 유지, 과채 유래 유산균(L. plantarum CJLP133), 프로바이오틱스 ATP 등을 들 수 있다.Specific examples of such compounds or extracts include Enterococcus , which is individually recognized as a function of 'hypersensitive immune response' function according to the Act on Health Functional Foods complexes such as faecalis heat-treated dry powder, a guava leaf extract, Actinidia extract, lobular extract, Picard off retrograde complexes, such as powder, PLAG (1-palmitoyl-2 -linoleoyl-3-acetyl-rac-glycerol) , and a "sensitive skin L. sakei Probio 65, L. plantarum CJLP133, gamma-linolenic acid-containing oil, and probiotic ATP.
이러한 화합물 또는 천연 추출물은 본 발명의 항알러지용 조성물에 그 유효성분과 함께 하나 이상 포함될 수 있다.Such compounds or natural extracts may be included in the antiallergic composition of the present invention in combination with one or more thereof.
본 발명의 항알러지용 조성물은 구체적인 양태에 있어서, 식품 조성물로서 파악할 수 있다.The anti-allergy composition of the present invention can be identified as a food composition in a specific embodiment.
본 발명의 식품 조성물은 어떠한 형태로도 제조될 수 있으며, 예컨대 차, 쥬스, 탄산음료, 이온음료 등의 음료류, 우유, 요구루트 등의 가공 유류, 껌류, 떡, 한과, 빵, 과자, 면 등의 식품류, 정제, 캡슐, 환, 과립, 액상, 분말, 편상, 페이스트상, 시럽, 겔, 젤리, 바 등의 건강기능식품 제제류 등으로 제조될 수 있다. 또 본 발명의 식품 조성물은 법률상·기능상의 구분에 있어서 제조·유통 시점의 시행 법규에 부합하는 한 임의의 제품 구분을 띨 수 있다. 예컨대 건강기능식품에관한법률에 따른 건강기능식품이거나, 식품위생법의 식품공전(식약처 고시, 식품의 기준 및 규격)상 각 식품유형에 따른 과자류, 두류, 다류, 음료류, 특수용도식품 등일 수 있다.The food composition of the present invention can be prepared in any form and can be used in various forms such as beverages such as tea, juice, carbonated drink, ionic drink, processed milk such as milk and request route, gum, rice cake, Korean confectionery, Such as foods, tablets, capsules, rings, granules, liquids, powders, flakes, pastes, syrups, gels, jellies, bars and the like. In addition, the food composition of the present invention may be classified into any product category as long as it meets the laws and regulations on the time of manufacture and distribution in the legal and functional category. For example, it may be a health functional food according to the Act on Health Functional Foods, or a confectionery, bean curd, beverage, beverage, special-purpose food, etc. according to each food type in the Food Code (Food Standards, .
본 발명의 식품 조성물에는 그 유효성분 이외에 식품첨가물이 포함될 수 있다. 식품첨가물은 일반적으로 식품을 제조, 가공 또는 보존함에 있어 식품에 첨가되어 혼합되거나 침윤되는 물질로서 이해될 수 있는데, 식품과 함께 매일 그리고 장기간 복용되므로 그 안전성이 보장되어야 한다. 식품위생법에 따른 식품첨가물공전(식약처 고시, 식품첨가물 기준 및 규격)에는 안전성이 보장된 식품첨가물이 화학적 합성품, 천연 첨가물, 혼합 제제류로 구분하여 한정적으로 규정되어 있는데, 이러한 식품첨가물은 기능적 측면에 있어서는 감미제, 풍미제, 보존제, 유화제, 산미료, 점증제 등으로 구분될 수 있다. The food composition of the present invention may contain food additives in addition to the active ingredients thereof. Food additives are generally understood to be substances that are added to foods and mixed or infiltrated into food in the manufacture, processing or preservation of food, and their safety must be ensured since they are taken daily with food and for long periods. The Food Additive Ordinance according to the Food Sanitation Law (Food Additives Standards, Standards and Standards for Food Additives) is limited to the classification of safe food additives as chemical synthetic, natural additives and mixed preparations. Sweeteners, flavors, preservatives, emulsifiers, acidifiers, and thickeners.
감미제는 식품에 적당한 단맛을 부여하기 위하여 사용되는 것으로, 천연의 것이거나 합성된 것을 사용할 수 있다. 바람직하게는 천연 감미제를 사용하는 경우인데, 천연 감미제로서는 옥수수 시럽 고형물, 꿀, 수크로오스, 프룩토오스, 락토오스, 말토오스 등의 당 감미제를 들 수 있다. A sweetener is used to impart a sweet taste suitable for foods, and natural or synthetic sweeteners can be used. Preferably, natural sweeteners are used. Examples of natural sweeteners include sugar sweeteners such as corn syrup solids, honey, sucrose, fructose, lactose and maltose.
풍미제는 맛이나 향을 좋게 하기 위하여 사용될 수 있는데, 천연의 것과 합성된 것 모두 사용될 수 있다. 바람직하게는 천연의 것을 사용하는 경우이다. 천연의 것을 사용할 경우에 풍미 이외에 영양 강화의 목적도 병행할 수 있다. 천연 풍미제로서는 사과, 레몬, 감귤, 포도, 딸기, 복숭아 등에서 얻어진 것이거나 녹차잎, 둥굴레, 대잎, 계피, 국화 잎, 자스민 등에서 얻어진 것일 수 있다. 또 인삼(홍삼), 죽순, 알로에 베라, 은행 등에서 얻어진 것을 사용할 수 있다. 천연 풍미제는 액상의 농축액이나 고형상의 추출물일 수 있다. 경우에 따라서 합성 풍미제가 사용될 수 있는데, 합성 풍미제로서는 에스테르, 알콜, 알데하이드, 테르펜 등이 이용될 수 있다. Flavors may be used to enhance taste or flavor, both natural and synthetic. Preferably, a natural one is used. When using natural ones, the purpose of nutritional fortification can be performed in addition to the flavor. Examples of natural flavoring agents include those obtained from apples, lemons, citrus fruits, grapes, strawberries, peaches, and the like, or those obtained from green tea leaves, Asiatica, Daegu, Cinnamon, Chrysanthemum leaves and Jasmine. Also, those obtained from ginseng (red ginseng), bamboo shoots, aloe vera, banks and the like can be used. The natural flavoring agent may be a liquid concentrate or a solid form of extract. If desired, a synthetic flavor agent may be used. As the synthetic flavor agent, esters, alcohols, aldehydes, terpenes and the like may be used.
보존제로서는 소르브산칼슘, 소르브산나트륨, 소르브산칼륨, 벤조산칼슘, 벤조산나트륨, 벤조산칼륨, EDTA(에틸렌디아민테트라아세트산) 등이 사용될 수 있고, 또 유화제로서는 아카시아검, 카르복시메틸셀룰로스, 잔탄검, 펙틴 등이 사용될 수 있으며, 산미료로서는 연산, 말산, 푸마르산, 아디프산, 인산, 글루콘산, 타르타르산, 아스코르브산, 아세트산, 인산 등이 사용될 수 있다. 산미료는 맛을 증진시키는 목적 이외에 미생물의 증식을 억제할 목적으로 식품 조성물이 적정 산도로 되도록 첨가될 수 있다.As the preservative, calcium sorbate, sodium sorbate, potassium sorbate, calcium benzoate, sodium benzoate, potassium benzoate, EDTA (ethylenediaminetetraacetic acid) and the like can be used, and as the emulsifier, acacia gum, carboxymethyl cellulose, xanthan gum, pectin And acidulant, malic acid, fumaric acid, adipic acid, phosphoric acid, gluconic acid, tartaric acid, ascorbic acid, acetic acid, phosphoric acid and the like may be used as the acidulant. The acidulant may be added so that the food composition has a proper acidity for the purpose of inhibiting the growth of microorganisms other than the purpose of enhancing the taste.
점증제로서는 현탁화 구현제, 침강제, 겔형성제, 팽화제 등이 사용될 수 있다.Examples of the thickening agent include suspending agents, sedimentation agents, gel-forming agents, bulking agents and the like.
본 발명의 식품 조성물은 전술한 바의 식품첨가물 이외에, 기능성과 영양성을 보충, 보강할 목적으로 당업계에 공지되고 식품첨가물로서 안정성이 보장된 생리활성 물질이나 미네랄류를 포함할 수 있다.The food composition of the present invention may contain physiologically active substances or minerals which are known in the art and which are stable as a food additive in addition to the above-mentioned food additives in order to supplement and supplement functional and nutritional properties.
그러한 생리활성 물질로서는 녹차 등에 포함된 카테킨류, 비타민 B1, 비타민 C, 비타민 E, 비타민 B12 등의 비타민류, 토코페롤, 디벤조일티아민 등을 들 수 있으며, 미네랄류로서는 구연산칼슘 등의 칼슘 제제, 스테아린산마그네슘 등의 마그네슘 제제, 구연산철 등의 철 제제, 염화크롬, 요오드칼륨, 셀레늄, 게르마늄, 바나듐, 아연 등을 들 수 있다. Examples of such physiologically active substances include catechins contained in green tea and the like, vitamins such as vitamin B1, vitamin C, vitamin E and vitamin B12, tocopherol, dibenzoyl thiamine, etc. Examples of minerals include calcium preparations such as calcium citrate, magnesium stearate , Iron preparations such as iron citrate, chromium chloride, potassium iodide, selenium, germanium, vanadium, zinc and the like.
본 발명의 식품 조성물에는 전술한 바의 식품첨가물이 제품 유형에 따라 그 첨가 목적을 달성할 수 있는 적량으로 포함될 수 있다.The food composition of the present invention may contain an appropriate amount of the above-mentioned food additives according to the product type so as to achieve the purpose of addition thereof.
본 발명의 식품 조성물에 포함될 수 있는 기타의 식품첨가물과 관련하여서는 식품위생법에 따른 식품공전이나 식품첨가물 공전을 참조할 수 있다.With regard to other food additives that may be included in the food composition of the present invention, reference may be made to the Food Code or the Food Additive Code in accordance with the Food Sanitation Law.
본 발명의 조성물은 다른 구체적인 양태에 있어서는 약제학적 조성물로 파악될 수 있다.In another specific embodiment, the composition of the present invention can be identified as a pharmaceutical composition.
본 발명의 약제학적 조성물은 유효성분 이외에 약제학적으로 허용되는 담체를 포함하여 당업계에 공지된 통상의 방법으로 투여 경로에 따라 경구용 제형 또는 비경구용 제형으로 제조될 수 있다. 여기서 "약제학적으로 허용되는" 의미는 유효성분의 활성을 억제하지 않으면서 적용(처방) 대상이 적응 가능한 이상의 독성을 지니지 않는다는 의미이다.The pharmaceutical composition of the present invention may be prepared into oral formulations or parenteral formulations according to the route of administration by conventional methods known in the art, including pharmaceutically acceptable carriers in addition to the active ingredient. The term "pharmaceutically acceptable" as used herein means that the application (prescribing) subject does not have the above-mentioned toxicity that is adaptable without inhibiting the activity of the active ingredient.
본 발명의 약제학적 조성물이 경구용 제형으로 제조될 경우, 적합한 담체와 함께 당업계에 공지된 방법에 따라 분말, 과립, 정제, 환제, 당의정제, 캡슐제, 액제, 겔제, 시럽제, 현탁액, 웨이퍼 등의 제형으로 제조될 수 있다. 이때 약제학적으로 허용되는 적합한 담체의 예로서는 락토스, 글루코스, 슈크로스, 덱스트로스, 솔비톨, 만니톨, 자일리톨 등의 당류, 옥수수 전분, 감자 전분, 밀 전분 등의 전분류, 셀룰로오스, 메틸셀룰로오스, 에틸셀룰로오스, 나트륨 카르복시메틸셀룰로오스, 하이드록시프로필메틸셀룰로오스 등의 셀룰로오스류, 폴리비닐 피롤리돈, 물, 메틸히드록시벤조에이트, 프로필히드록시벤조에이트, 마그네슘 스테아레이트, 광물유, 맥아, 젤라틴, 탈크, 폴리올, 식물성유 등을 들 수 있다. 제제화활 경우 필요에 따라 충진제, 증량제, 결합제, 습윤제, 붕해제, 계면활성제 등의 희석제 및/또는 부형제를 포함하여 제제화할 수 있다.When the pharmaceutical composition of the present invention is prepared into an oral formulation, it may be formulated into powder, granules, tablets, pills, sugar tablets, capsules, solutions, gels, syrups, suspensions, wafers And the like. Examples of suitable pharmaceutically acceptable carriers include sugars such as lactose, glucose, sucrose, dextrose, sorbitol, mannitol, xylitol, starch such as corn starch, potato starch and wheat starch, cellulose, methylcellulose, ethylcellulose, Cellulose derivatives such as sodium carboxymethyl cellulose and hydroxypropylmethyl cellulose, polyvinyl pyrrolidone, water, methylhydroxybenzoate, propylhydroxybenzoate, magnesium stearate, mineral oil, malt, gelatin, talc, And the like. In case of formulation, a diluent such as a filler, an extender, a binder, a wetting agent, a disintegrant, a surfactant, and / or an excipient may be formulated according to need.
본 발명의 약제학적 조성물이 비경구용 제형으로 제조될 경우, 적합한 담체와 함께 당업계에 공지된 방법에 따라 주사제, 경피 투여제, 비강 흡입제 및 좌제의 형태로 제제화될 수 있다. 주사제로 제제화할 경우 적합한 담체로서는 멸균수, 에탄올, 글리세롤이나 프로필렌 글리콜 등의 폴리올 또는 이들의 혼합물을 사용할 수 있으며, 바람직하게는 링거 용액, 트리에탄올 아민이 함유된 PBS(phosphate buffered saline)나 주사용 멸균수, 5% 덱스트로스 같은 등장 용액 등을 사용할 수 있다. 경피 투여제로 제제화할 경우 연고제, 크림제, 로션제, 겔제, 외용액제, 파스타제, 리니멘트제, 에어롤제 등의 형태로 제제화할 수 있다. 비강 흡입제의 경우 디클로로플루오로메탄, 트리클로로플루오로메탄, 디클로로테트라플루오로에탄, 이산화탄소 등의 적합한 추진제를 사용하여 에어로졸 스프레이 형태로 제제화할 수 있으며, 좌제로 제제화할 경우 그 기제로는 위텝솔(witepsol), 트윈(tween) 61, 폴리에틸렌글리콜류, 카카오지, 라우린지, 폴리옥시에틸렌 소르비탄 지방산 에스테르류, 폴리옥시에틸렌 스테아레이트류, 소르비탄 지방산 에스테르류 등을 사용할 수 있다.When the pharmaceutical composition of the present invention is prepared into a parenteral dosage form, it may be formulated in the form of an injection, transdermal drug delivery, nasal aspirate and suppository together with a suitable carrier according to methods known in the art. As the carrier suitable for injection preparation, sterilized water, ethanol, polyol such as glycerol or propylene glycol, or a mixture thereof, may be used, and preferably, a solution of Ringer's solution, phosphate buffered saline containing triethanolamine or sterilized by injection Water, or isotonic solution such as 5% dextrose may be used. When formulated with a transdermal preparation, it can be formulated in the form of ointments, creams, lotions, gels, external liquids, pastes, liniments, and air-lozenges. The nasal inhalant may be formulated in the form of an aerosol spray using a suitable propellant such as dichlorofluoromethane, trichlorofluoromethane, dichlorotetrafluoroethane, carbon dioxide, etc. When formulated as a suppository, witepsol, tween 61, polyethylene glycols, cacao butter, laurin, polyoxyethylene sorbitan fatty acid esters, polyoxyethylene stearates, and sorbitan fatty acid esters.
약제학적 조성물의 제제화와 관련하여서는 당업계에 공지되어 있으며, 구체적으로 문헌[Remington's Pharmaceutical Sciences(19th ed., 1995)] 등을 참조할 수 있다. 상기 문헌은 본 명세서의 일부로서 간주 된다.The formulation of pharmaceutical compositions is well known in the art and can be specifically described in Remington ' s Pharmaceutical Sciences (19th ed., 1995). This document is considered part of this specification.
본 발명의 약제학적 조성물의 바람직한 투여량은 환자의 상태, 체중, 성별, 연령, 환자의 중증도, 투여 경로에 따라 1일 0.001mg/kg ~ 10g/kg 범위, 바람직하게는 0.001mg/kg ~ 1g/kg 범위일 수 있다. 투여는 1일 1회 또는 수회로 나누어 이루어질 수 있다. 이러한 투여량은 어떠한 측면으로든 본 발명의 범위를 제한하는 것으로 해석되어서는 아니 된다. The preferred dosage of the pharmaceutical composition of the present invention is 0.001 mg / kg to 10 g / kg per day, preferably 0.001 mg / kg to 1 g / day, depending on the patient's condition, body weight, sex, age, / kg < / RTI > The administration can be carried out once or several times a day. Such dosages should in no way be construed as limiting the scope of the invention.
본 발명의 항알러지용 조성물은 구체적인 양태에 있어서, 화장료 조성물로 파악할 수 있다.The composition for anti-allergy of the present invention can be identified as a cosmetic composition in a specific embodiment.
본 발명의 조성물이 화장료 조성물로 파악될 경우에도 그 화장료 조성물은 그 용도상, 법률상 임의의 제품 구분을 띨 수 있으며, 구체적으로 피부 트러블 개선, 아토피 피부염 개선 등의 용도를 가진 기능성 화장품, 비기능성 일반 화장품 등일 수 있다. 제품 형태에 있어서도 임의의 제품 형태를 띨 수 있는데, 구체적으로 용액, 현탁액, 유탁액, 페이스트, 젤, 크림, 로션, 파우더, 비누, 계면활성제-함유 클렌징, 오일, 분말 파운데이션, 유탁액 파운데이션, 왁스 파운데이션, 스프레이 등의 제품 형태를 띨 수 있다. 구체적인 제품 형태에 있어서는 유연 화장수, 영양 화장수, 영양 크림, 마사지 크림, 에센스, 아이 크림, 클렌징 크림, 클렌징 포옴, 클렌징 워터, 팩, 스프레이 또는 파우더의 제형 등일 수 있다.Even when the composition of the present invention is identified as a cosmetic composition, the cosmetic composition may be classified into any product category according to the use of the cosmetic composition. Specifically, the cosmetic composition may contain functional cosmetic products having applications such as improvement of skin troubles and improvement of atopic dermatitis, General cosmetics, and the like. Specific examples of the product form include a solution, suspension, emulsion, paste, gel, cream, lotion, powder, soap, surfactant-containing cleansing oil, powder foundation, emulsion foundation, wax Foundation, spray, and the like. In a specific product form, it may be a form of flexible lotion, nutritional lotion, nutritional cream, massage cream, essence, eye cream, cleansing cream, cleansing foam, cleansing water, pack, spray or powder.
본 발명의 화장료 조성물은 그 유효성분 이외에 화장료 조성물에 통상적으로 이용되는 성분들, 예컨대, 안정화제, 용해화제, 계면활성제, 비타민, 색소 및 항료와 같은 통상적인 보조제, 및 담체를 포함할 수 있다. The cosmetic composition of the present invention may contain, in addition to its active ingredient, conventional additives such as stabilizers, solubilizing agents, surfactants, vitamins, colorants and antioxidants, and carriers commonly used in cosmetic compositions.
본 발명의 제형이 페이스트, 크림 또는 젤인 경우에는 담체 성분으로서 동물성유, 식물성유, 왁스, 파라핀, 전분, 트라칸트, 셀룰로오스 유도체, 폴리에틸렌 글리콜, 실리콘, 벤토나이트, 실리카, 탈크 또는 산화아연 등이 이용될 수 있다.When the formulation of the present invention is a paste, a cream or a gel, an animal oil, vegetable oil, wax, paraffin, starch, tracant, cellulose derivative, polyethylene glycol, silicone, bentonite, silica, talc or zinc oxide may be used as a carrier component .
본 발명의 제형이 파우더 또는 스프레이인 경우에는 담체 성분으로서 락토스, 탈크, 실리카, 알루미늄 히드록시드, 칼슘 실리케이트 또는 폴리아미드 파우더가 이용될 수 있고, 특히 스프레이인 경우에는 추가적으로 클로로플루오로히드로카본, 프로판/부탄 또는 디메틸 에테르와 같은 추진체를 포함할 수 있다.When the formulation of the present invention is a powder or a spray, lactose, talc, silica, aluminum hydroxide, calcium silicate or polyamide powder may be used as a carrier component. In the case of a spray, in particular, / Propane or dimethyl ether.
본 발명의 제형이 용액 또는 유탁액인 경우에는 담체 성분으로서 용매, 용해화제 또는 유탁화제가 이용되는데, 구체적으로 물, 에탄올, 이소프로판올, 에틸 카보네이트, 에틸 아세테이트, 벤질 알코올, 벤질 벤조에이트, 프로필렌 글리콜, 1,3-부틸글리콜 오일, 글리세롤 지방족 에스테르, 폴리에틸렌 글리콜, 소르비탄의 지방산 에스테르 등이 이용될 수 있다.When the formulation of the present invention is a solution or emulsion, a solvent, a solubilizing agent or an emulsifying agent is used as a carrier component. Specifically, water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, 1,3-butyl glycol oil, glycerol aliphatic ester, polyethylene glycol, fatty acid esters of sorbitan, and the like.
본 발명의 제형이 현탁액인 경우에는 담체 성분으로서 물, 에탄올 또는 프로필렌 글리콜과 같은 액상의 희석제, 에톡실화 이소스테아릴 알코올, 폴리옥시에틸렌 소르비톨 에스테르, 폴리옥시에틸렌 소르비탄 에스테르와 같은 현탁제, 미소결정성 셀룰로오스, 알루미늄 메타히드록시드, 벤토나이트, 아가 등이 이용될 수 있다.When the formulation of the present invention is a suspension, a carrier, such as water, a liquid diluent such as ethanol or propylene glycol, a suspension such as ethoxylated isostearyl alcohol, polyoxyethylene sorbitol ester, polyoxyethylene sorbitan ester, Cellulose, aluminum metahydroxide, bentonite, agar, etc. may be used.
본 발명의 제형이 계면-활성제 함유 클렌징인 경우에는 담체 성분으로서 지방족 알코올 설페이트, 지방족 알코올 에테르 설페이트, 설포숙신산 모노에스테르, 이세티오네이트, 이미다졸리늄 유도체, 메틸타우레이트, 사르코시네이트, 지방산 아미드 에테르 설페이트, 알킬아미도베타인, 지방족 알코올, 지방산 글리세리드, 지방산 디에탄올아미드, 식물성 유, 라놀린 유도체 또는 에톡실화 글리세롤 지방산 에스테르 등이 이용될 수 있다.When the formulation of the present invention is an interfacial active agent-containing cleansing, the carrier component is selected from aliphatic alcohol sulfate, aliphatic alcohol ether sulfate, sulfosuccinic acid monoester, isethionate, imidazolinium derivative, methyltaurate, sarcosinate, fatty acid amide Ether sulfates, alkylamidobetaines, aliphatic alcohols, fatty acid glycerides, fatty acid diethanolamides, vegetable oils, lanolin derivatives or ethoxylated glycerol fatty acid esters.
본 발명의 화장료 조성물은 항알러지 활성을 나타내는 그 유효성분을 포함하는 것을 제외하고는 당업계에 통상적으로 행하여지는 화장료 조성물의 제조방법에 따라 제조할 수 있다.The cosmetic composition of the present invention can be produced by a method for producing a cosmetic composition which is usually carried out in the art, except that it contains the active ingredient exhibiting antiallergic activity.
전술한 바와 같이, 본 발명에 따르면 정향풀 추출물을 이용한 항알러지용 조성물을 제공할 수 있다. As described above, according to the present invention, it is possible to provide a composition for anti-allergy using an extract of Clove grass.
본 발명의 항알러지용 조성물은 알러지 질환의 개선 등의 용도로 식품, 화장품, 약품 등으로 제품화될 수 있다.The antiallergic composition of the present invention can be commercialized into foods, cosmetics, medicines, etc. for the purpose of improving allergic diseases and the like.
도 1은 정향풀 추출물의 IgE 및 항원(DNP-BSA)으로 활성화된 비만세포주 RBL-2H3(rat basophilic leukemia)에서의 탈과립 억제 활성을 보여주는 결과이다.FIG. 1 shows the results of demonstrating the degranulation inhibitory activity in IgE and anti-DNP-BSA-activated mast cell extract RBL-2H3 (rat basophilic leukemia).
이하 본 발명을 실시예 및 실험예를 참조하여 설명한다. 그러나 본 발명의 범위가 이러한 실시예 및 실험예에 한정되는 것은 아니다.Hereinafter, the present invention will be described with reference to Examples and Experimental Examples. However, the scope of the present invention is not limited to these examples and experimental examples.
<< 실시예Example > 정향풀> Cling paste 추출물의 제조 Preparation of extract
건조한 정향풀(Amsonia elliptica) 전초 분말에 5배 중량의 70% 에탄올을 가하여 상온에서 24 시간 1회 침지추출 후 여과지로 여과하였다. 얻어진 70% 에탄올 여액을 감압 농축 후 동결 건조하여 정향풀 추출물을 얻었다. (추출 부위, 용매 등 확인 바랍니다) Dried clove ( Amsonia elliptica) after 24 hours immersion extraction once at room temperature was added a 70% ethanol of 5 times the weight of the sentinel powder was filtered with a filter paper. The resulting 70% ethanol filtrate was concentrated under reduced pressure and then lyophilized to obtain an extract of Clove grass. (Please check the extraction site, solvent, etc.)
<< 실험예Experimental Example 2> 2> 항알러지Anti-allergy 활성 실험 Active experiment
정향풀 추출물의 항알러지 활성을 확인하기 위하여 아래와 같이 β-hexosaminidase assay를 통해 비만세포주의 탈과립 억제 활성을 평가하였다. In order to confirm the antiallergic activity of the extract of clove extract, the degranulation inhibitory activity of the mast cell line was evaluated by β-hexosaminidase assay as follows.
Rat basophilic leukemia 셀 라인인 RBL-2H3 세포주를 15% FBS, 100 unit/ml의 페니실린과 스트렙토마이신을 포함하는 MEM 배지와 37℃, 5% CO2 조건에서 24 well plate에 2×105/well로 분주한 후 24시간 배양하였다. The RBL-2H3 cell line, a Rat basophilic leukemia cell line, was cultured in MEM medium containing 15% FBS, 100 units / ml penicillin and streptomycin at 37 ° C and 5% CO 2 in a 24-well plate at 2 × 10 5 / well Followed by incubation for 24 hours.
상등액을 제거 후 25 ng/ml anti-DNP IgE가 포함된 MEM 배지를 넣고 4시간 배양하였다. 배양 후 PIPES buffer (25mM PIPES, 119mM NaCl, 5mM KCl, 1mM CaCl2, 0.4mM MgCl2, 40mM NaOH, 5.6mM glucose, 0.1% BSA)로 두 번 세척하고 10분 동안 전 배양하였다. 전 배양 후 실시예의 시료를 농도별로 20분간 처리 후 DNP-BSA 20분간 반응시켰다. Ice에 10분간 방치하여 반응을 종결시킨 후 상등액을 96 well plate에 넣고, 1mM P-니트로페닐-아세틸-β-D-글루코사미니드를 넣은 후 37℃에서 1시간 반응시켰다. stop solution(0.1M NaHCO3, O.1M Na2CO3)를 넣고 반응을 종결시킨 후 405nm 파장대에서 ELISA 리더로 흡광도를 측정하였다. 양성 대조군으로는 ketotifen(100 ㎍/ml)을 사용하였다.The supernatant was removed and MEM medium containing 25 ng / ml anti-DNP IgE was added and cultured for 4 hours. After incubation, the cells were washed twice with PIPES buffer (25 mM PIPES, 119 mM NaCl, 5 mM KCl, 1 mM CaCl 2 , 0.4 mM MgCl 2 , 40 mM NaOH, 5.6 mM glucose, 0.1% BSA) and preincubated for 10 minutes. After the pre-incubation, the samples of the examples were treated for 20 minutes by concentration and then reacted for DNP-BSA for 20 minutes. Ice was left for 10 minutes to terminate the reaction. The supernatant was added to a 96-well plate, and 1 mM P-nitrophenyl-acetyl-β-D-glucosaminyl was added thereto, followed by reaction at 37 ° C. for 1 hour. stop solution (0.1 M NaHCO 3 , 0.1 M Na 2 CO 3 ), and the absorbance was measured with an ELISA reader at a wavelength of 405 nm. Ketotifen (100 ㎍ / ml) was used as a positive control.
결과를 [도 1] 에 나타내었는데, 실시예의 시료는 농도 의존적으로 탈과립을 억제함을 알 수 있으며, IC50은 77.65 ㎍/mL로 나타났다. 양성 대조군인 ketotifen의 경우는 IC50이 38.97 ㎍/mL를 보였다. 양성 대조군으로 사용한 ketotifen은 항히스타민제로서 알러지성 비염, 아토피 등 알러지성 피부 질환, 알러지성 천식 등에 쓰이는 약물이다.The results are shown in Fig. 1, which shows that the samples of the examples suppressed degranulation in a concentration-dependent manner, and the IC 50 was 77.65 占 퐂 / mL. In the positive control ketotifen, IC 50 was 38.97 ㎍ / mL. Ketotifen, used as a positive control, is an antihistamine drug used for allergic asthma, allergic skin diseases such as allergic rhinitis and atopy.
Claims (6)
An antiallergic composition comprising an extract of Amsonia elliptica as an active ingredient.
상기 정향풀(Amsonia elliptica) 추출물은 물, 에탄올 또는 이들의 혼합 용매로 추출하여 얻은 추출물인 것을 특징으로 하는 항알러지용 조성물.
The method according to claim 1,
Wherein the Amsonia elliptica extract is an extract obtained by extracting with water, ethanol or a mixed solvent thereof.
상기 항알러지는 알러지성 질환의 개선, 치료, 그러한 질환의 발병 억제 또는 지연을 의미하고,
상기 알러지성 질환은 아토피 피부염(atopic dermatitis), 천식(asthma), 알러지성 비염(allergic rhinitis), 알러지성 결막염(allergic conjunctivitis), 알러지성 피부염(allergic dermatitis), 알러지성 접촉성 피부염(allergic contact dermatitis), 및 알러지성 각막염로 구성된 군에서 선택된 하나인 것을 특징으로 하는 항알러지용 조성물.
The method according to claim 1,
The anti-allergy means improvement, treatment, inhibition or retardation of the onset of an allergic disease,
The allergic diseases are selected from the group consisting of atopic dermatitis, asthma, allergic rhinitis, allergic conjunctivitis, allergic dermatitis, allergic contact dermatitis ), And allergic keratitis. ≪ RTI ID = 0.0 > 21. < / RTI >
상기 조성물은 약제학적 조성물인 것을 특징으로 하는 항알러지용 조성물.
4. The method according to any one of claims 1 to 3,
Wherein the composition is a pharmaceutical composition.
상기 조성물은 식품 조성물인 것을 특징으로 하는 항알러지용 조성물.
3. The method according to claim 1 or 2,
Wherein the composition is a food composition.
상기 조성물은 화장품 조성물인 것을 특징으로 하는 항알러지용 조성물.3. The method according to claim 1 or 2,
Wherein the composition is a cosmetic composition.
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