KR101839491B1 - Extraction Method of Houttuynia cordata Thunberg Extract and Cosmetic materials Using the same - Google Patents
Extraction Method of Houttuynia cordata Thunberg Extract and Cosmetic materials Using the same Download PDFInfo
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- A—HUMAN NECESSITIES
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
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- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
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Abstract
The present invention relates to a method for extracting an active ingredient from a plant by hydrothermal extraction or methanol extraction method and extracting the extracted extract to inhibit the free radical reaction without causing irritation and safety to the skin of the human body, The present invention relates to a method for extracting a herbal extract having an antioxidative effect by increasing the resistance of a cell and a cosmetic composition using the same.
In order to solve the above problems, the present invention provides a cosmetic composition for antioxidation containing Houttuynia cordata Thunberg extract as an active ingredient.
Description
More particularly, the present invention relates to a method for extracting Hwasungi extract and a cosmetic composition using the same, and more particularly, to a method for extracting an active ingredient from a Hwasungcho extract using a hot water extraction method or a methanol extraction method, The present invention relates to a method of extracting a herring root extract having an antioxidative effect by increasing the resistance of skin cells against ultraviolet rays and the like by inhibiting free radical reaction without inducing skin diseases, and a cosmetic composition using the same.
Due to the development of medical technology, the lifespan of the human body has been extended, and there has been a growing interest in health care and prevention of skin aging.
Free radicals that cause aging and diseases of the human body are formed by physical, chemical and biological stresses during normal metabolic processes in the body, which damage the cell membrane, cause proteolysis and lipid peroxidation, Disorder or the like. Furthermore, by attacking lipsome, deoxyribose and protein, it induces oxidation and promotes aging of human body and various adult diseases such as arteriosclerosis, rheumatoid arthritis, chronic inflammation and cancer.
The theory of free radicals was presented by D. Harman in the mid-1950s, and has recently attracted attention from the academic and related industries.
There are many causes of free radicals in the human body. These radicals cause cell destruction, breakage of the connective tissue of the dermal layer of the skin, or cross-linking, leading to wrinkles, skin cancer, cell killing, rheumatoid arthritis, Dermatitis, and acne.
Free radicals can be caused by the action of white blood cells, the electron transfer system, myeloperoxide (MPO), ultraviolet rays, tobacco, normal metabolism, stress, pollutants and bacteria during the production of ATP in mitochondria .
Of course, the body has antioxidants (radical scavenging agents) such as superoxide dismutase (SOD), catalase, vitamin E, vitamin C, and uviquinol. However, gradually the antioxidant system is disintegrated by age, pollution, ultraviolet rays and stress, the antioxidant system is disabled, and free radicals are gradually increased.
This increased free radical destroys collagen, elastin, and hyaluronic acid, which are connective tissues of the dermis, causing a settling of the skin (wrinkles) and oxidizing the lipid part of the cell membrane, Causing skin diseases, acne, skin cancer and the like. In addition, the free radicals are involved in a spontaneous oxidation reaction (dopaquinone → melanin) during melanin formation, and cause free radicals and cause wrinkles.
Recent studies have shown that lipid peroxidation by oxidative stress causes Alzheimer's disease (AD), which is considered to be a degenerative neurological disorder.
These physiological actions that inhibit free radicals such as oxidative stress include hydrogen peroxidase, catalase, and superoxide dismutase (SOD), which converts superoxide anion radicals into steady state oxygen, and donates electrons to free radicals There is a non-enzymatic reaction system such as electron donating action and analogous activity for inhibiting oxidation.
On the other hand, Houttuynia cordata Thunberg belonging to Saururus chinensis is the underside of the flowering period of the wheat wheat, and is named because of the fishy smell of the leaves. In ancient China 's Qin country, it was called the author (菹 子), a plant that smells like a salted fish.
It is used for pneumonia, acute chronic bronchitis, enteritis, urinary tract infections and boils. It is also used when there is a lot of heat and urine. Antimicrobial activity, immune enhancement, antiinflammatory action, diuretic action and vasodilating action were reported by pharmacological action of Hwasungcho. In addition, Horseshoe purifies the blood, increases the substances of isoquercetrin and quercetrin plus alpha, and promotes blood circulation of the capillaries.
In addition, it has been reported that Hwasungcho is a traditional medicinal plant and has a wide range of therapeutic effects including species, syphilis, cystitis, hemorrhoids, pneumonia, and stroke. Up to now, studies on Hwasungcho have been conducted on the antimicrobial activity, And hypercholesterolemia. Quercitrin, a physiologically active substance, has been reported to have various physiological activities.
As a technique relating to a cosmetic composition using an extract of Aspergillus oryzae, Patent Document 10-200-0058332 discloses a cosmetic or pharmaceutical composition for the treatment and prevention of acne, comprising the extract of Aspergillus oryzae, A cosmetic composition containing a combination of a sari, a monocotyledonous extract and a semi-synthetic extract having anti-inflammatory effect, a cosmetic composition containing a mixture of a sardine, a fennel, a jojoba oil, a tea trioyl, a flaxseed oil, Cosmetic composition for improvement of atopic skin related to flushing and whitening of atopic skin using mint oil, spinach, spinach, cabbage, propolis and rice flour, Patent Document 10-2015-0136677, A cosmetic composition which comprises the composition of the present invention and a composition containing the composition of the present invention as disclosed in Korean Patent Publication No. 10-2015-0010691, And a herbal cosmetic composition for scalp protection and hair loss prevention, and a process for producing the same.
The above technologies are related to functional foods and pharmaceutical compositions using Hwasungcho extract. Various functional foods and pharmaceutical compositions using Hwasungcho have been studied. However, studies on antioxidant cosmetic compositions have been limited.
Disclosure of Invention Technical Problem [8] The present invention has been made to solve the above-mentioned problems, and it is an object of the present invention to provide a cosmetic composition using an extracted active ingredient.
In order to solve the above problems, the present invention provides a cosmetic composition for antioxidation containing Houttuynia cordata Thunberg extract as an active ingredient.
The cosmetic composition of the present invention is characterized by containing 0.1-20.0% by weight of the extract of Rhododendron syrup extract according to the total weight of the cosmetic composition.
At this time, the Hwasungcho extract is extracted using hot water extraction method or solvent extraction method using methanol.
In the hot water extraction method described above, the dried whiting plant is washed with water, and water is removed and weighed to produce a whitening powder sample. The whitening powder is added to the
In the solvent extraction method using the methanol, the dried greens were washed with water, the water was removed, and the greens were weighed and weighed. The greens were pulverized and then washed with 100 g of 60% methanol, And the mixture was refluxed and cooled for 2 hours. The extracted extract was filtered with a filter paper, concentrated using a rotary evaporator, and dried.
The extract of Hwasung extract obtained by the hot water extraction method and the methanol extraction method according to the present invention contains a large amount of an active ingredient of antioxidant function and the cosmetic composition prepared using the active ingredient has a problem of causing non-irritating and safe skin diseases Can be improved.
In addition, the cosmetic composition using the extract of Hwasung extract according to the present invention has an advantage in antioxidant ability, wrinkle improvement and inflammation treatment which increases the resistance of skin cells against ultraviolet rays and the like by inhibiting free radical reaction.
FIG. 1 is a graph showing the cell survival rate of the Houttuynia cordata extract prepared by the extraction method of Houttuynia cordata extract according to the present invention.
FIG. 2 is a graph showing the total phenol content of the Houttuynia cordata extract prepared by the extraction method of Houttuynia cordata extract according to the present invention.
FIG. 3 is a graph showing the DPPH radical scavenging activity of the Houttuynia cordata extract prepared by the extraction method of Houttuynia cordata extract according to the present invention.
Hereinafter, preferred embodiments of the present invention will be described in detail with reference to the accompanying drawings.
The present invention relates to a method for extracting an active ingredient from a perennial herb by hot water extraction or methanol extraction and then extracting the extracted active ingredient to inhibit the free radical reaction without causing irritation to the skin of the human body, The present invention relates to a method for extracting a herbal extract having an antioxidative effect by increasing the resistance of a cell and a cosmetic composition using the same.
The method for extracting Hwasungsus extract according to the present invention and the components contained in Hwasungcho used in the cosmetic composition using the same will be described below.
Houttuynia cordata Thunberg includes, but is not limited to, methylene-nonyl ketone, decanoyl acetaldehyde, laurylaldehyde, caprylaldehyde, cortalin, quercitrin, isoquercitrin, quercetin, rutin, rainotrine, It contains geranil, calcium chloride, and calcium sulfate. It has been found to have capillary strengthening, vasodilating, and diuretic effects. According to studies on antiviral activity in Rhizoctonia sp., It is known that antiviral functions against herpes virus and the like are known to exist in the extracts obtained by high temperature steam extraction method in Rhizoctonia spp.
Accordingly, in the present invention, the extract of Houttuynia cordata extract obtained by the hot water extraction method and the solvent extraction method using methanol is used.
Production Example 1. Preparation of Houttuynia cordata extract by hot water extraction
The dried persimmon was purchased from a medicinal plant in Gwangju Metropolitan City. The purchased material was washed in running water, and then water was removed and weighed to make a weighing capacity.
Sodium starch powder samples were sterilized by adding sterilized purified water, which was 10 times the weight of the sample, and boiled at 80 ° C for 24 hours. The extracts were repeatedly extracted three times.
After the extraction, the mixture was filtered through a filter paper (Advantec No. 2), concentrated using a rotary vacuum concentrator (N-1000, Eyela, Japan) and dried to prepare an extract of Houttuynia cordata. At this time, the yield was calculated by gravimetric method, and concentrated herringbone extract was stored at 4 ° C.
Production Example 2. Preparation of Houttuynia cordata extract using methanol extraction method
The sample purchased in Preparation Example 1 was washed with flowing water, and water was removed and weighed to make a weighing capacity.
5 g of the fish starch powder sample was added to 100 mL of 60% methanol and reflux cooled for 2 hours.
After extraction, the mixture was filtered with a filter paper (Advantec No. 2), concentrated using a rotary vacuum concentrator (N-1000, Eyela, Japan) and dried to prepare a Houttuynia cordata extract. At this time, the yield was calculated by gravimetric method, and concentrated herringbone extract was stored at 4 ° C.
As a result of measuring the content of each phenol in the extract of Hwasungcho extract by changing the concentration of methanol to 50%, 60%, 70% and 80% in the preparation example 2, it was found that when 60% of methanol was used, And the methanol extraction method using 60% methanol is used in the present invention.
Experimental Example 1. Cell culture
Human keratinocyte cell line (HaCaT) cells were treated with 10% fetal bovine serum (FBS) and penicillin (100 units / mL) / streptomycin (100 μg / mL) was added to the cells and cultured in a CO 2 cell incubator (NU-4750G, NuAire, USA) under 5% CO 2 feed. Subculture was performed every 2-3 days.
Experimental Example 2. Measurement of cell viability
(HH) by hot water extraction method and Horseradish root extract (HM) by methanol extraction method) and hot water extraction method and methanol extraction method by methanol extraction method (HHM), diluted by the concentration, and each sample was uniformly distributed in a 96-well plate at 5 × 10 3 cells / well. After 24 h, each extract was treated at different concentrations to obtain 72h Lt; / RTI >
Cell proliferation assay was performed using the Cell Titer AQueous One Solution Cell proliferation assay kit (Promega, USA).
After incubation, the medium was removed, and 100 μL of DMEM medium and 100 μL of 3- (4,5-dimethylthia zol-2-yl) -5- (3-carboxymethoxyphenyl) -2- (4-sulfophenyl) solution was added and reacted at 5% CO 2 and 37 ° C for 3 h. The absorbance was measured at 490 nm using an ELISA reader (Infinite ™ F200, TECAN, Switzerland). The culture medium without sample treatment was used as a control.
At this time, the cell viability was calculated according to the following formula 1.
Equation 1)
Cell viability (%) = (absorbance of sample-added group / absorbance of control group) x 100
FIG. 1 is a graph showing the cell survival rate of the Houttuynia cordata extract prepared by the extraction method of Houttuynia cordata extract according to the present invention.
As shown in FIG. 1, the cell viability (cytotoxicity) of the extract of Hwasung extract prepared by the hot water extraction method and the solvent extraction method using methanol was higher than that of the control Survival rate was high. Especially, the extracts of Houttuynia cordata extracts by hot water extraction showed higher or similar cell survival rate than the control and higher than 100 μg / mL. The cell viability was similar to that of the control group up to 100 μg / mL, but the cell survival rate was lowered to 80% or less compared with the control group at 200 μg / mL. Therefore, it is safe to use a concentration of less than 200 μg / mL of the extract or mixture of Hwasung extract extracted by each extraction method in the cytotoxicity experiment.
Experimental Example 3. Analysis of total phenol content
In order to measure the content of phenol which shows antioxidant ability, 4 mL of distilled water was mixed with 0.25 mL of sample solution (HH, HM) and mixture (HHM) 0.25 mL of a Folin-Ciocalteau's reagent was added, vortexed for 30 seconds, allowed to react for 5 minutes, and then 0.5 mL of saturated sodium carbonate was added. The mixture was allowed to stand at room temperature for 30 minutes and absorbance was measured at 725 nm using a UV-VIS spectrophotometer Respectively.
FIG. 2 is a graph showing the total phenol contents of the Houttuynia cordata extract prepared by the extraction method of Houttuynia cordata extract according to the present invention.
2, the total phenol content was found to be 78.9 mM Tannic acid / g in the case of Horschia peach extract (HH) by the hot water extraction method, and 77.8 mM Tannic acid / g in the casein extract (HM) There was no significant difference between the two extracts. However, the mixture of Horseradish Horticultural Extract (HHM) extracted by hot water extraction method and methanol extraction method was measured with 67.3 mM Tannic acid / g extract, and relatively low phenol content was detected than the single group Horticultural extracts.
Therefore, the single group extracts were found to be more advantageous in sulfur oxidation ability than the mixed group extracts.
As described above, it is known that phenolic compounds are present in the perennial herb. Examples thereof include qurcitrin, qurcetin and hyperoside, and the presence of the phenol compounds can be confirmed through the graph of the phenol content.
That is, in the present invention, the total phenol content did not show any significant difference in other conditions of the extract, but it was found to be present in both the water extract method and the 60% methanol extract method.
In addition, phenol exhibited excellent efficacy in the deterioration of liver function, diabetes, antiinflammatory renal toxicity, and neuroprotection, which are diseases caused by oxides. According to the results of Experimental Example 3, It can be deduced that the effect depending on the oxide will appear.
Experimental Example 4. Analysis of DPPH radical scavenging ability
The DPPH radical scavenging activity was measured by the Blois method, which is widely used for measuring antioxidant activity.
(HH) by hot water extraction method and Horseradish root extract (HM) by methanol extraction method) and hot water extraction method and methanol extraction method by methanol extraction method DPHH free reducing power against radical scavenging activity was measured using 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical (Sigma, USA).
For the experimental method, 250 μL of a 0.2 mM DPPH solution dissolved in ethanol was added to 500 μL of each sample, mixed well with a shaker, allowed to react at room temperature for 30 min, and then analyzed using a UV / VIS spectrophotometer (Optizen 2120 UV, Mecasys, Absorbance was measured at 517 nm.
As control, ethanol was used instead of DPPH. The activity inhibition rate of DPPH was calculated according to the following equation (2).
Equation 2)
Radical scavenging activity (%) = (1 - (sample absorbance - control absorbance) / control absorbance) × 100
FIG. 3 is a graph showing the DPPH radical scavenging activity of the Houttuynia cordata extract prepared by the extraction method of Houttuynia cordata extract according to the present invention.
3, the DPPH radical scavenging ability was the lowest at 10 μg / mL concentration in the case of Hwanghae extract (HH) by hydrothermal extraction method, H2S extract (HM) and mixture (HHM) by methanol extraction method However, as the concentration increased, free radical scavenging ability was measured in a concentration dependent manner.
Particularly, DPPH radical scavenging ability of DPPH radical scavenging ability was higher than that of DPPH radical scavenging ability when the concentration was 100 μg / mL or more in the case of Hwanghwang extract (HH), methanol extract of Hwasungcho extract (HM) and mixture (HHM) Respectively.
Oxidative stress causes cell damage by free radicals generated in vivo, resulting in aging and disease.
DPPH (2,2-diphenyl-1-picrylhydrazyl) is a free radical compound and is used for the measurement of free radical scavenging ability. It is used to measure antioxidative ability by using reducing ability such as tocopherol and ascorbic acid which are aromatic compounds and amines.
From the above Experimental Example 4, it can be seen that the free radical scavenging reaction proceeds through reduction of DPPH during the DPPH reaction, which is a stable model of free radicals, according to the present invention.
As a result of these experiments, the degree of inhibition of the initial lipid peroxidation reaction is predictable.
That is, active oxygen is sometimes called harmful oxygen. Unsaturated fatty acid is a constituent of cellular membrane, and active oxygen attacks unsaturated fatty acid to induce lipid peroxidation reaction and accumulates lipid peroxidation in the body. This causes deterioration of vital function and at the same time it is known to cause aging and diseases of adult diseases. In addition, antioxidative effects by various kinds of plant components and extracts have been reported.
Accordingly, the extract of Hwasung extract according to the present invention has an antioxidant activity measured by DPPH and has a free radical scavenging ability of 80% or more at a concentration of 100 μg / mL or more.
As described above, the extract of Rhododendron sulphate according to the present invention can be mixed with the material constituting the cosmetic composition, and the cosmetic composition preferably contains 0.1-20.0 wt% of the Rhododendron sphaericus extract based on the total weight of the cosmetic composition.
The extract of Hwasungcho extract obtained by the hot water extraction method and the methanol extraction method according to the present invention contains a large amount of an active ingredient of antioxidant function and the cosmetic composition prepared using the extract has a problem of causing non-irritating and safe skin diseases And the cosmetic composition using the extract of Rhododendron sulphate according to the present invention has an advantage in antioxidative ability, wrinkle improvement and inflammation treatment which increases the resistance of skin cells against ultraviolet rays and the like by inhibiting free radical reaction.
The ingredients contained in the cosmetic composition of the present invention include, in addition to the above-mentioned effective ingredients, the components commonly used in cosmetic compositions as an active ingredient of the Horseshoe extract, and are commonly used in cosmetics such as antioxidants, stabilizers, solubilizers, vitamins, And a carrier.
In addition, the cosmetic composition of the present invention may be prepared in any form conventionally produced in the art, and examples thereof include solutions, suspensions, emulsions, pastes, gels, creams, lotions, powders, soaps, surfactants- Containing cleansing, oil, powder foundation, emulsion foundation, wax foundation and spray, but is not limited thereto. More specifically, it can be manufactured in the form of a soft lotion, a nutritional lotion, a nutritional cream, a massage cream, an essence, an eye cream, a cleansing cream, a cleansing foam, a cleansing water, a pack, a spray or a powder.
When the formulation of the present invention is a paste, cream or gel, an animal oil, vegetable oil, wax, paraffin, starch, tracant, cellulose derivative, polyethylene glycol, silicone, bentonite, silica, talc or zinc oxide may be used as the carrier component .
When the formulation of the present invention is a powder or a spray, lactose, talc, silica, aluminum hydroxide, calcium silicate or polyamide powder may be used as the carrier component, and in the case of a spray, Propane / butane or dimethyl ether.
When the formulation of the present invention is a solution or an emulsion, a solvent, a dissolving agent or an emulsifying agent is used as a carrier component, and examples thereof include water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, , 3-butyl glycol oil, glycerol aliphatic ester, polyethylene glycol or sorbitan fatty acid esters.
In the case where the formulation of the present invention is a suspension, a carrier such as water, a liquid diluent such as ethanol or propylene glycol, a suspending agent such as ethoxylated isostearyl alcohol, polyoxyethylene sorbitol ester and polyoxyethylene sorbitan ester, Cellulose, aluminum metahydroxide, bentonite, agar or tracant, etc. may be used.
When the formulation of the present invention is an interfacial active agent-containing cleansing, the carrier component is selected from aliphatic alcohol sulfate, aliphatic alcohol ether sulfate, sulfosuccinic acid monoester, isethionate, imidazolinium derivative, methyltaurate, sarcosinate, fatty acid amide Ether sulfates, alkylamidobetaines, aliphatic alcohols, fatty acid glycerides, fatty acid diethanolamides, vegetable oils, lanolin derivatives or ethoxylated glycerol fatty acid esters.
While the present invention has been particularly shown and described with reference to exemplary embodiments thereof, it is to be understood that the invention is not limited to the disclosed exemplary embodiments, but, on the contrary, It will be understood by those skilled in the art that various changes in form and details may be made therein without departing from the spirit and scope of the invention as defined by the appended claims.
Claims (4)
Washing the dried whiting plant with water, removing moisture, crushing the weed by weighing capacity, and then preparing a whitening powder sample;
5 g of the above-mentioned spherical seed powder was added to 100 ml of 60% methanol, and the mixture was refluxed for 2 hours for extraction; And
The extracts of the above-mentioned Hwasung extract are filtered with a filter paper, concentrated using a rotary evaporator and dried,
The method of extracting Hwasung extract according to claim 1, wherein the Hwangsu extract is used in an amount of 50 to 200 占 퐂 / ml based on the cosmetic composition.
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| KR102186282B1 (en) * | 2018-11-13 | 2020-12-03 | 코스맥스엔에스 주식회사 | Detoxification composition comprising houttuynia cordata and zingiber officinale and preparation method thereof |
| CN117653594B (en) * | 2023-12-12 | 2024-06-18 | 海南华研胶原科技股份有限公司 | Preparation method and application of collagenase inhibitor |
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