KR101780191B1 - Re-useable injector device for syringe - Google Patents
Re-useable injector device for syringe Download PDFInfo
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- KR101780191B1 KR101780191B1 KR1020157027577A KR20157027577A KR101780191B1 KR 101780191 B1 KR101780191 B1 KR 101780191B1 KR 1020157027577 A KR1020157027577 A KR 1020157027577A KR 20157027577 A KR20157027577 A KR 20157027577A KR 101780191 B1 KR101780191 B1 KR 101780191B1
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- housing
- assembly
- injector device
- syringe
- outer housing
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
- A61M5/2033—Spring-loaded one-shot injectors with or without automatic needle insertion
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
- A61M5/31566—Means improving security or handling thereof
- A61M5/3157—Means providing feedback signals when administration is completed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
- A61M5/3202—Devices for protection of the needle before use, e.g. caps
- A61M5/3204—Needle cap remover, i.e. devices to dislodge protection cover from needle or needle hub, e.g. deshielding devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/46—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for controlling depth of insertion
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
- A61M2005/2006—Having specific accessories
- A61M2005/202—Having specific accessories cocking means, e.g. to bias the main drive spring of an injector
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
- A61M2005/206—With automatic needle insertion
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
- A61M2005/2073—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically preventing premature release, e.g. by making use of a safety lock
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
- A61M2005/2073—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically preventing premature release, e.g. by making use of a safety lock
- A61M2005/208—Release is possible only when device is pushed against the skin, e.g. using a trigger which is blocked or inactive when the device is not pushed against the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
- A61M2005/2403—Ampoule inserted into the ampoule holder
- A61M2005/2407—Ampoule inserted into the ampoule holder from the rear
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
- A61M2005/2418—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic comprising means for damping shocks on ampoule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
- A61M2005/2485—Ampoule holder connected to rest of syringe
- A61M2005/2492—Ampoule holder connected to rest of syringe via snap connection
Abstract
The injector device includes an injector body for receiving the injector; And an injection assembly configured to dispense the medicament from the syringe at a dispensing step. Certain types of injection devices include a rapid completion indicator that indicates when the injection is complete. Certain types of injector devices are configured to dispense two different pharmaceutical agents having different viscosities from a syringe without any change to the injector devices without altering the syringes. Certain types of injector devices include safety devices that inhibit the firing of the injector device until the front and rear housing assemblies are positioned at predetermined rotational and axial positions relative to one another.
Description
The medicament may be dispensed from the syringe using an injector device. Some injector devices are spring-loaded so the user only needs to trigger the trigger to dispense the drug. Certain types of injector devices also automatically inject the needle into the injection site prior to dispensing the drug. For example, certain types of injector devices start to operate when the forward of the injector device is pushed against the injection site. Certain types of injector devices are "one-shot" devices. Other types of injector devices are configured to be reused by allowing the used syringe to be switched out to a replacement syringe. Certain types of injector devices include an indicator that provides an indication of how many times the injector device has injected the drug or how many drugs have been dispensed.
According to some aspects of the present disclosure, an injector device includes a first housing assembly configured to hold a syringe; A second housing assembly; A locking member; And an interlocking assembly configured to rotatably attach the first housing assembly to the second housing assembly in a specific rotational position. The second housing assembly includes an outer housing and an inner housing. The inner housing is configured to be axially fixed relative to the first housing assembly. The outer housing is configured to move axially relative to the first housing assembly between an extended position and a retracted position. The second housing assembly includes an injection assembly configured to actuate a syringe to inject a medicament from the syringe. The second housing assembly includes a trigger member configured to fire the injection assembly only when the outer housing is in the retracted position. The second housing assembly includes a biasing member that biases the outer housing to an extended position. The locking member securely holds the outer housing in the extended position. The interlocking assembly is configured to release the locking member such that the outer housing is retracted relative to the first housing assembly in a retracted position against deflection of the deflection member.
According to other aspects of the present disclosure, an injector device includes an injector body including a front assembly and a rear assembly that cooperate to form an interior; syringe; And an injection assembly disposed within the interior of the syringe body. The front assembly includes a front housing, a syringe carrier movable between a rearward position and a forward position relative to the front housing, a first damper disposed rearward of the front housing, and a second damper disposed rearward of the syringe carrier. The syringe carrier engages the first damper when in the forward position and the syringe carrier is spaced from the first damper when in the back position. The syringe is configured to be coupled to the syringe carrier for movement with the syringe carrier. The syringe includes an ampoule, a needle, and a plunger. The needle extends from the first end of the ampoule and the plunger extends from the second end of the ampoule. At least a portion of the ampoule engages the second damper. The ampoule is configured to hold a common volume of any one of the two or more different pharmaceutical agents in the injector device without modification. The first of the two different pharmaceutical agents has a first viscosity and the second of the two different pharmaceutical agents has a second viscosity different from the first viscosity. The injector assembly is configured to dispense the drug formulation held by the syringe. The injector assembly includes a ram driven by a constant load spring. The release of the constant force spring drives the syringe carrier from the rearward position to the forward position until the syringe carrier engages the first damper. The constant force spring drives the plunger within the ampule of the syringe after the syringe carrier is positioned in the forward position. The first and second dampers cooperate to prevent damage to the ampoule during movement of the syringe carrier and plunger movement.
According to certain aspects of the present disclosure, the injector device includes a sudden completion indicator member disposed within the interior of the injector body. The quick completion indicator member is configured to move between a first position and a second position with respect to the injector body. The rapid completion indicator member is visible through the window in the injector body when in the first position and through the window when in the second position. The movement of the rapid completion indicator member from the first position to the second position is activated upon completion of the dispensing step.
Additional aspects of the various aspects of the invention will be set forth in the detailed description which follows. Aspects of the present invention may relate to individual features and combinations of features. It is to be understood that both the foregoing general description and the following detailed description are exemplary and explanatory only and are not restrictive of the invention's inventive concepts, on the basis of the disclosed embodiments.
BRIEF DESCRIPTION OF THE DRAWINGS The accompanying drawings, which are incorporated in and constitute a part of the specification, illustrate several aspects of the present disclosure. A brief description of the drawing is as follows:
1 is a front perspective view of an exemplary injector apparatus constructed in accordance with the principles of the present disclosure;
Figure 2 is a front perspective view of the injector device of Figure 1 with the lid remover removed from the injector device;
Figure 3 is an exploded view of the injector device of Figure 1;
Figure 4 is a side view of the injector device of Figure 1 with the front assembly separated axially from the rear assembly;
Figure 5 is an axial cross-sectional view of the injector device of Figure 4 with the front assembly flipped to face the rear assembly;
Figure 6 is a side view of the injector device of Figure 4 with the front end of the front assembly inserted into the front end of the rear assembly to mount the injection system of the injector device;
Figure 7 is an axial cross-sectional view of the injector device of Figure 6;
Figure 8 is an axial cross-sectional view of the front assembly of the injector device of Figure 1 shown with the syringe loaded into the front assembly;
Figure 9 is an enlarged view of a cross section of the forward end of the injector device of Figure 1 with the syringe loaded so that the cover remover of the front assembly engages the needle cover;
Figure 10 shows a lid remover and needle cover removed from the injector device of Figure 9;
11 is a side view of the front assembly of FIG. 10 with the syringe loaded therein and the lid remover removed;
Figure 12 is a perspective view of the rear assembly of Figure 4, shown in axial cross-section and separated from the front assembly;
Figure 13 is a side view of the injector device of Figure 1 disposed in an extended position of the rear housing;
Figure 14 is a side view of the injector device of Figure 13, with the rear housing disposed in a retracted position;
Figure 15 is an axial cross-sectional view of the injector device of Figure 13;
Figure 16 is an axial cross-sectional view of the injector device of Figure 14,
Figure 17 is a perspective view of the inner housing of the rear assembly that is positioned relative to the illustrated front assembly away from the outer housing of the rear assembly so that the interlocking arms and the rearwardly extending tabs are visible;
18 is an enlarged perspective view of a portion of Fig. 17;
Figure 19 is a rear perspective view of the front assembly of Figure 16 showing a lateral cross-section of the interlocking arm;
20 is a perspective view of a trigger button disposed about the ledge structure of the inner housing;
FIG. 21 is an axial cross-sectional view of the injector device of FIG. 16 wherein the trigger button is depressed and the ram of the injection assembly is released from the cocked position and the syringe carriage is bottomed out;
22 is an axial cross-sectional view of the injector device of FIG. 21 in which the plunger is fully drawn out of the syringe and a rapid completion indicator is located in the forward position;
Figure 23 is a perspective view of the injector device of Figure 2, in which the needle of the injector projects from the front of the injector device and the completion indicator is located in the forward position.
DETAILED DESCRIPTION OF THE INVENTION Reference will now be made in detail to the exemplary aspects of the present disclosure illustrated in the accompanying drawings. Wherever possible, the same reference numbers will be used throughout the drawings to refer to the same or like parts.
In general, the present disclosure relates to an injector device configured to hold a syringe and an injection assembly. The injection assembly is configured to dispense the drug from the syringe (i.e., to release fluid from the syringe) in a dispensing step. In some embodiments, the injection assembly is also configured to move the syringe from the retracted position to the extended position to inject (i.e., insert the needle into the injection position) into the syringe in the injection step. In certain embodiments, the injector device is reusable. For example, the syringe can be removed after use and replaced with a new syringe.
According to some embodiments, the injector device has a completion indicator indicating that the medicament has been dispensed and the user can withdraw the needle from the injection position. In certain embodiments, the completion indicator is a quick completion indicator. For example, the completion indicator only operates at the completion of the distribution step. As used herein, the term " at completion "refers to a time including a moment of completion, a time immediately after completion, a time within a few milliseconds before and after completion (i.e., Quot;). The display provided by the quick completion indicator is not changed until the dispensing is complete. In some implementations, the quick completion indicator includes a window and a color change is visible through this window when the distribution is complete. In certain implementations, the expedited completion indicator includes an audible tone that is generated when distribution is complete. In certain implementations, the quick completion indicator includes both a color change and an audible tone.
According to some embodiments, the injector device is configured for use with syringes that can have any one of two or more different formulations. The formulation used in the syringe can be switched between the two formulations without adjustment to the injector device. For example, the injector device may be used with a first syringe having a special medication of 20 milligrams in a particular volume. The first syringe can be replaced with a second syringe containing 40 milligrams of the drug in the same volume after injection. The injector device may be injected and dispensed into the second syringe without any adjustment to the injector device.
The same injector device may receive either the first or second syringe. For example, the sizes of the first syringe and the second syringe may be substantially the same. Parts of the injector device need not be modified to switch to a formulation that is scaled or moved or otherwise being loaded. For example, the same constant load spring, the same ram arrangement and the same plunger depth can be used with both syringes. Thus, prior to each injection, the user may select whether to inject the injector device with either the first or second agent. The syringe carrier and the damping zones on the carrier holder suppress the breakage of the syringe during scanning and dispensing. For example, the damping zones may be damaged by syringe breakage during injection (e.g., cracking, breaking, and / or fracturing of the ampoule, deformation or displacement of the needle hub relative to the ampule, Or other impairments). ≪ / RTI >
According to some embodiments, the injector device includes safety devices that precisely assemble the injector device and press it against the injection position in a predetermined amount of force and inhibit the firing of the injector device until the trigger is actuated. For example, even when the trigger button of the injector device is depressed when a predetermined amount of force is not applied to the injector device, the injection assembly will not operate to inject into the syringe or dispense the drug. In some embodiments, the injector device includes a front assembly and a rear assembly, which are rotationally aligned and axially moved toward each other before the trigger will trigger the injection assembly.
Figures 1 and 2 illustrate an
The
As shown in Figure 3, the
In some embodiments,
In some embodiments, the
In some embodiments, the
The
The display portion 121 (Figs. 1 and 2) is provided on the outer surface of the
The
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As shown in FIG. 9, the
3, the
The
3, the
The
The
The
The
In some embodiments, an
The
The
The rear
The
In some embodiments, one or both of the
The interlocking
In some embodiments,
As shown in FIG. 12, the
When the rear
FIGS. 4-7 illustrate how the
The front end of the
FIGS. 8-11 illustrate mounting the
As shown in FIG. 8, the
10, when the
12 illustrates a cross-sectional view of the
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While the
As shown in FIG. 12, the
Figures 13-19 illustrate how the
15 and 16 are axial cross-sectional views of the
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FIGS. 17-19 illustrate how
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In some embodiments, the interlocking
FIGS. 16 and 20-22 illustrate the operation of the
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As shown in Fig. 21, the
As shown in FIG. 22, the
Referring to Figures 16, 21, and 22, a
22, the
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As noted above, the phrase "at completion" includes the time of completion, time immediately after completion, or time within a few milliseconds before or after completion (e.g., by tolerance within the injection device) Frame can be referred to. When multiple events occur "on completion", they can occur simultaneously, in another event immediately following an event, or within several milliseconds within each other. In some embodiments, when the
In some embodiments, the
The
COPAXONE® is a trade name for a formulation containing glatiramer acetate as an active ingredient. Glatiramer Acetate is approved to reduce the frequency of recurrences in relapsing-remitting multiple sclerosis (RRMS). Glatiramer Acetate contains four naturally occurring amino acids: L-glutamic acid, L-alanine, L-tyrosine, and L-lysine, which have an average molar fraction of COPAXONE® of 0.141, 0.427, 0.095 and 0.338, It consists of acetate salts of synthetic polypeptides. In COPAXONE®, the average molecular weight of glatiramer acetate is 4,700 to 11,000 daltons. Chemically, glatiramer acetate is a designated L-glutamic acid polymer with L-alanine, L-lysine and L-tyrosine, acetate (salt). Its structure is as follows:
(Glu, Ala, Lys, Tyr ) x ACH 3 COOH
(C 5 H 9 NO 4 AC 3 H 7 NO 2 AC 6 H 14 N 2 O 2 AC 9 H 11 NO 3 ) P APC 2 H 4 O 2
CAS-147245-92-9.
Recurrent relief The recommended dosing schedule for COPAXONE® for multiple sclerosis is subcutaneously injected at 20 mg / d (Physician's Desk Handbook). Additional information on dosing schedules may also be found in U.S. Patent Nos. 3,849,550; 5,800,808; 5,859, 964, 5,981, 589; 6,048, 898; 6,054, 430; 6,214, 791; 6,342, 476; And 6,362,161, the disclosures of which are hereby incorporated by reference herein.
Although the mechanism of its action is not fully described, it is believed that the GA is bound to a major histocompatibility complex (MHC) molecule and displayed as an antigen in the groove of this molecule. Alternatively, GA is thought to be enveloped by antigen presenting cells (APCs) and fragments are then provided. Either way, the provision of GA results in the generation of GA-specific T cells. Through still unclear mechanisms, GA-specific T-cells are mostly biased T helper 2 (Th2). Th2 cells produce Th2 cytokines that inhibit the production of cytokines by Th1 cells or macrophages, and are intended to be anti-inflammatory agents. Unlike interferon-beta, which has a distinctly strong action in the blood-brain barrier (BBB) that reduces the migration of inflammatory cells to the CNS, GA has a negligible effect on BBB, suggesting that GA- specific Th2 lymphocytes (Young et al., 2002).
Some aspects of the injector device include (a) a first housing assembly configured to hold a syringe; (b) a second housing assembly including an outer housing and an inner housing; (c) a locking member firmly holding the outer housing in an extended position; And (d) an interlocking assembly configured to rotatably attach the first housing assembly to the second housing assembly at a particular rotational position. The inner housing is configured to be axially fixed relative to the first housing assembly. The outer housing is configured to move axially relative to the first housing assembly between the extended and retracted positions. The second housing assembly includes an injection assembly configured to actuate the syringe to inject the medicament from the syringe. The second housing assembly includes a trigger member configured to launch the injection assembly only when the outer housing is in the retracted position. The second housing assembly includes a biasing member that biases the outer housing to an extended position. The interlocking assembly is also configured to release the locking member when the first and second housing assemblies are in a particular rotational position. The outer housing is actuated relative to the first housing assembly in the depressed position against deflection of the biasing member when the locking member is released.
In certain example implementations, the first housing assembly includes a first alignment indicator, and the outer housing of the second housing assembly includes a second alignment indicator, wherein the first and second alignment indicators are positioned between the first and second alignment indicators, 2 When the housing assemblies are oriented to a particular rotational position.
In certain example implementations, the interlocking assembly includes an interlocking band visible between the first housing assembly and the second housing assembly when the outer housing is disposed in an extended position, wherein when the outer housing is in the retracted position Interlocking bands are not visible.
In certain example implementations, the locking member includes a flexible latching hook disposed on the inner housing, the latching hook configured to engage a shoulder disposed on the interior of the outer housing, wherein the interlocking assembly includes a first And a tab that bends the latching hook away from the shoulder when the second housing assemblies are directed to a particular rotational position.
In certain example implementations, the trigger member is mounted to the outer housing and includes a button configured to move between a ready position and a pushed position. The button is spaced far enough away from the injection assembly when the outer housing is located in the extended position, thereby inhibiting the button from firing the injection assembly even when in the depressed position. By moving the outer housing to the retracted position, the button is moved sufficiently close to the injection assembly to allow firing of the injection assembly when the button is moved to the depressed position.
In certain example implementations, the injection assembly includes a ram and a spring biasing the ram toward the syringe. The ram includes a flexible latch arm that engages a shoulder formed by the inner housing to hold the ram against deflection of the spring. Moving the buttons sufficiently close to the injection assembly involves moving the button within the range of the flexible latch such that movement of the button to the depressed position biases the flexible latch away from the shoulder to release the ram.
In certain example implementations, the biasing member deflects the outer housing toward the extended position by deflecting the button away from the inner housing and toward the ready position.
In certain example implementations, the outer housing moves relative to the first housing assembly when the first housing assembly is abutted against the injection side and the user grasps the outer housing and pushes the outer housing toward the injection site.
In certain example implementations, the syringe contains a formulation comprising glatiramer acetate. In one exemplary implementation, the formulation comprises 20 mg glatiramer acetate per ml of formulation. In one exemplary implementation, the formulation comprises 40 mg of glatiramer acetate per ml of formulation.
In certain example implementations, the syringe includes a needle configured to extend from a first housing assembly during a dispensing step, wherein the first housing assembly includes a depth adjuster that changes the length of the needle extending from the first housing assembly.
In certain example implementations, the depth adjuster is actuated between separate stop positions, each separate stop position corresponding to a different needle depth, by moving the depth adjuster to one of the different stop positions, Select the needle depth.
In certain example implementations, the needle cover remover is assembled on the depth adjuster. The needle cover remover is configured to couple with the depth adjuster such that the depth adjuster is fixed in the axial and rotational directions during any movement of the needle cover remover.
In certain example implementations, a number is displayed on the depth adjuster to indicate the needle depth, wherein the displayed number is at least 4 mm in size.
In certain example implementations, the second housing assembly includes a compressible gripping surface that extends over a portion of the exterior of the second housing assembly.
In certain example implementations, each of the first and second housing assemblies includes a threaded region that secures to the other threaded region for coupling the first and second housing assemblies.
In certain example implementations, each of the threaded regions includes a thread extending approximately within the inner periphery of the respective housing assembly.
In certain example implementations, the threads of each threaded region extend approximately half of the inner circumference of each housing assembly.
In certain example implementations, the first housing assembly includes a first tab and the second housing assembly defines a snap-over surface, wherein when the first and second housing assemblies are threaded together, Over surface, wherein the first tab creates an audible sound when the first tab is raised over the snap-over surface.
In certain example implementations, a rapid completion indicator member is disposed within the interior of the outer housing. The quick completion indicator member is configured to move relative to the outer housing between the first and second positions. Wherein the rapid completion indicator member is visible through the window when in the first position but not through the window formed in the outer housing and in the second position wherein movement from the first position to the second position of the quick completion indicator member is effected by the dispensing It is activated upon completion of the step.
In certain example implementations, the color change is visible through the window as the fast completion indicator member moves from the first position to the second position.
In certain example implementations, the injector device generates an audible tone upon completion of the dispensing step.
In certain example implementations, the rapid completion indicator member is deflected toward the second right hand by a biasing member, wherein the injection assembly comprises at least one stationary member that holds the quick completion indicator member against deflection of the biasing member, The stop member automatically releases the indicator member upon completion of the dispensing step.
The above specification, examples and data provide a complete description of the manufacture and use of the present invention. Numerous embodiments of the invention can be made without departing from the spirit and scope of the invention, which in the claims hereafter falls within the scope of the appended claims.
references
1. Lampert, autoimmune and virus-induced dehydration diseases, review, Am. J. Path. , 1978, 91: 176-208.
2. Johnson, et al.,
3. Filippi et al., Glatiramer Acetate Reduces the Rate of MS Transition to Black Hole, Neurol . , ≪ / RTI > 2001, 57: 731-733.
4. The table in the doctor's Manual for "COPAXONE®", Thompson Reuters - doctors desk Handbook Inc., Montvale, NJ, 2008, 3110-3113 for.
5. Young (2002) "Differential mechanisms of the action of interferon-β and glatiramer acetate in MS" Neurology , 59: 1-7.
Claims (24)
(a) a first housing assembly configured to hold a syringe;
(b) a second housing assembly comprising an outer housing and an inner housing, wherein the inner housing is configured to be axially fixed relative to the first housing assembly, the outer housing having an outer housing and an inner housing, 1 housing assembly, the second housing assembly including an injection assembly configured to actuate the syringe to inject a medicament from the syringe, wherein the second housing assembly is configured to move the syringe And a trigger member configured to fire the injection assembly only when in the retracted position, the second housing assembly including a biasing member biasing the outer housing to an extended position;
(c) a locking member firmly holding the outer housing in the extended position; And
(d) an interlocking assembly configured to rotatably attach the first housing assembly to the second housing assembly at a particular rotational position, the interlocking assembly further comprising a first housing assembly having the first and second housing assemblies Wherein the outer housing is movable relative to the first housing assembly to the retracted position against deflection of the biasing member when the locking member is released, ,
Injector device.
Wherein the first housing assembly includes a first alignment indicator and the outer housing of the second housing assembly includes a second alignment indicator and wherein the first and second alignment indicators are positioned between the first and second housing assemblies When aligned to the specific rotational position,
Injector device.
Wherein the interlocking assembly includes an interlocking band visible between the first housing assembly and the second housing assembly when the outer housing is disposed in the extended position and wherein when the outer housing is in the retracted position, Mutual locking bands are invisible,
Injector device.
Wherein the locking member comprises a flexible latching hook disposed in the inner housing and the flexible latching hook is configured to engage a shoulder disposed within the outer housing, And a tab that flexes the flexible latching hook away from the shoulder when the housing assemblies are oriented to the particular rotational position.
Injector device.
The trigger member includes a button mounted to the outer housing and configured to move between a ready position and a pushed position,
The button is prevented from launching the injection assembly even when the button is spaced far enough away from the injection assembly and even in the pushed position when the outer housing is disposed in the extended position, Moving the button to a retracted position moves the button sufficiently close to the injection assembly to enable firing of the injection assembly when the button is moved to the pushed position,
Injector device.
The injection assembly includes a ram and a spring biasing the ram toward the syringe, the ram includes a flexible latch arm engaging a shoulder formed by the inner housing to hold the ram against deflection of the spring ≪ / RTI &
Moving the button sufficiently close to the injection assembly includes moving the button into the range of the flexible latch such that movement of the button to the depressed position includes pushing the flexible latch away from the shoulder to release the ram ,
Injector device.
The biasing member deflecting the outer housing toward the extended position by deflecting the button away from the inner housing and toward the ready position,
Injector device.
The outer housing moves relative to the first housing assembly as the first housing assembly is pressed against the injection site and the user grasps the outer housing and pushes the outer housing toward the injection site.
Injector device.
Wherein the syringe comprises a formulation comprising glatiramer acetate,
Injector device.
The formulation is a 1 ml (milliliter) formulation containing 20 mg of glatiramer acetate,
Injector device.
The formulation is a 1 ml formulation comprising 40 mg glatiramer acetate,
Injector device.
Wherein the syringe includes a needle configured to extend from the first housing assembly during a dispensing step and the first housing assembly includes a depth adjuster that changes the length of the needle extending from the first housing assembly.
Injector device.
The depth adjuster is movable between separate stop positions, and each separate stop position corresponds to a different needle depth, so moving the depth adjuster to one of the different stop positions selects a corresponding needle depth In fact,
Injector device.
Further comprising a needle lid remover fitted over the depth adjuster, wherein the needle lid remover is configured to be coupled to the first housing assembly such that the depth adjuster is axially movable during any movement of the needle lid remover, A fixed state in the rotating direction,
Injector device.
The numbers are displayed to indicate the depth of the needle in the depth adjuster, and the numbers displayed are 4 mm or more in size,
Injector device.
Wherein the second housing assembly includes a compressible gripping surface extending over a portion of the exterior of the second housing assembly.
Injector device.
Wherein each of said first and second housing assemblies includes a threaded region and said threaded region is secured to another threaded region to couple said first and second housing assemblies,
Injector device.
Wherein each of the threaded regions includes a screw extending around the inner circumference so as not to exceed an inner circumference of the respective housing assembly.
Injector device.
The threads of each threaded region extending about half the inner circumference of the respective housing assembly,
Injector device.
The first housing assembly includes a first tab and the second housing assembly forms a snap-over surface, and the first tab is configured such that the first and second housing assemblies are threaded together Over surface and the first tab generates an audible sound as the first tab rides over the snap-over surface,
Injector device.
Wherein the quick completion indicator member is arranged to move relative to the outer housing between a first position and a second position and wherein the quick completion indicator member is configured to move between a first position and a second position, 1 is invisible through the window formed in the outer housing and is visible through the window when in the second position, and wherein movement of the rapid completion indicator member from the first position to the second position is visible through the window formed in the outer housing, On completion,
Injector device.
A color change is visible through the window as the rapid completion indicator member moves from the first position to the second position,
Injector device.
Wherein the injector device generates an audible sound upon completion of the dispensing step,
Injector device.
Wherein the rapid completion indicator member is deflected toward the second position by a biasing member and the injection assembly includes at least one stop member for holding the quick completion indicator against deflection of the biasing member, And automatically releasing the indicator member upon completion of the dispensing step,
Injector device.
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP13158407.0A EP2774639B1 (en) | 2013-03-08 | 2013-03-08 | Re-useable injector device for syringe |
EP13158407.0 | 2013-03-08 | ||
CA2808875 | 2013-03-08 | ||
CA2808875A CA2808875A1 (en) | 2013-03-08 | 2013-03-08 | Re-useable injector device for syringe |
US13/790,487 | 2013-03-08 | ||
US13/790,487 US8652100B1 (en) | 2013-03-08 | 2013-03-08 | Re-useable injector device for syringe |
PCT/IB2014/000860 WO2014140820A2 (en) | 2013-03-08 | 2014-03-07 | Re-useable injector device for syringe |
Publications (2)
Publication Number | Publication Date |
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KR20150126657A KR20150126657A (en) | 2015-11-12 |
KR101780191B1 true KR101780191B1 (en) | 2017-09-21 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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KR1020157027577A KR101780191B1 (en) | 2013-03-08 | 2014-03-07 | Re-useable injector device for syringe |
Country Status (11)
Country | Link |
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JP (1) | JP6073507B2 (en) |
KR (1) | KR101780191B1 (en) |
AU (2) | AU2014229581B2 (en) |
BR (1) | BR112015021548A2 (en) |
CL (1) | CL2015002524A1 (en) |
EA (1) | EA029122B1 (en) |
IL (1) | IL240559B (en) |
MX (1) | MX2015011451A (en) |
NZ (1) | NZ630376A (en) |
PE (1) | PE20151576A1 (en) |
ZA (1) | ZA201506670B (en) |
Citations (4)
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US20080294096A1 (en) | 2005-11-04 | 2008-11-27 | Medrad Inc. | Delivery of Agents Such as Cells to Tissue |
US20100094217A1 (en) | 2004-12-06 | 2010-04-15 | Wyrick Ronald E | Methods Performed by Medicine Injection Apparatuses |
WO2012025639A1 (en) | 2010-08-27 | 2012-03-01 | Novo Nordisk A/S | Medical injection device |
US20120232017A1 (en) | 2009-07-15 | 2012-09-13 | Ayelet Altman | Reduced volume formulation of glatiramer acetate and methods of administration |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI498137B (en) * | 2006-06-30 | 2015-09-01 | Abbvie Biotechnology Ltd | Automatic injection device |
GB2460398A (en) * | 2008-05-20 | 2009-12-02 | Owen Mumford Ltd | Auto-injector having a magnetic injection indicator and a needle sheath retainer |
GB2463034B (en) * | 2008-08-28 | 2012-11-07 | Owen Mumford Ltd | Autoinjection devices |
CA2697570C (en) * | 2009-07-15 | 2011-11-01 | Teva Pharmaceutical Industries, Ltd. | Reduced volume formulation of glatiramer acetate and methods of administration |
GB2474308A (en) * | 2009-10-12 | 2011-04-13 | Pa Knowledge Ltd | Syringe auto-injector system suitable for variable doses |
JP2013544158A (en) * | 2010-11-29 | 2013-12-12 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | Auto-medicinal module for use with a syringe delivery device |
EP4074355A1 (en) * | 2011-04-20 | 2022-10-19 | Amgen Inc. | Autoinjector apparatus |
-
2014
- 2014-03-07 BR BR112015021548A patent/BR112015021548A2/en not_active IP Right Cessation
- 2014-03-07 NZ NZ630376A patent/NZ630376A/en not_active IP Right Cessation
- 2014-03-07 JP JP2015560801A patent/JP6073507B2/en not_active Expired - Fee Related
- 2014-03-07 EA EA201591666A patent/EA029122B1/en not_active IP Right Cessation
- 2014-03-07 MX MX2015011451A patent/MX2015011451A/en unknown
- 2014-03-07 KR KR1020157027577A patent/KR101780191B1/en active IP Right Grant
- 2014-03-07 PE PE2015001894A patent/PE20151576A1/en not_active Application Discontinuation
- 2014-03-07 AU AU2014229581A patent/AU2014229581B2/en not_active Ceased
-
2015
- 2015-08-13 IL IL240559A patent/IL240559B/en not_active IP Right Cessation
- 2015-09-08 CL CL2015002524A patent/CL2015002524A1/en unknown
- 2015-09-09 ZA ZA2015/06670A patent/ZA201506670B/en unknown
-
2017
- 2017-03-22 AU AU2017201949A patent/AU2017201949A1/en not_active Abandoned
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20100094217A1 (en) | 2004-12-06 | 2010-04-15 | Wyrick Ronald E | Methods Performed by Medicine Injection Apparatuses |
US20080294096A1 (en) | 2005-11-04 | 2008-11-27 | Medrad Inc. | Delivery of Agents Such as Cells to Tissue |
US20120232017A1 (en) | 2009-07-15 | 2012-09-13 | Ayelet Altman | Reduced volume formulation of glatiramer acetate and methods of administration |
WO2012025639A1 (en) | 2010-08-27 | 2012-03-01 | Novo Nordisk A/S | Medical injection device |
Also Published As
Publication number | Publication date |
---|---|
AU2014229581B2 (en) | 2016-12-22 |
EA201591666A1 (en) | 2016-01-29 |
EA029122B1 (en) | 2018-02-28 |
IL240559B (en) | 2019-06-30 |
ZA201506670B (en) | 2016-12-21 |
AU2017201949A1 (en) | 2017-04-13 |
IL240559A0 (en) | 2015-10-29 |
MX2015011451A (en) | 2016-06-10 |
CL2015002524A1 (en) | 2016-02-19 |
NZ630376A (en) | 2016-09-30 |
JP6073507B2 (en) | 2017-02-01 |
BR112015021548A2 (en) | 2017-07-18 |
JP2016513485A (en) | 2016-05-16 |
PE20151576A1 (en) | 2015-11-19 |
KR20150126657A (en) | 2015-11-12 |
AU2014229581A1 (en) | 2015-09-17 |
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