KR101778773B1 - Composition for Improving, Preventing or Treating Obesity Comprising Ashwagandha and Glycyrrhiza uralensis Extract - Google Patents
Composition for Improving, Preventing or Treating Obesity Comprising Ashwagandha and Glycyrrhiza uralensis Extract Download PDFInfo
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- KR101778773B1 KR101778773B1 KR1020160027735A KR20160027735A KR101778773B1 KR 101778773 B1 KR101778773 B1 KR 101778773B1 KR 1020160027735 A KR1020160027735 A KR 1020160027735A KR 20160027735 A KR20160027735 A KR 20160027735A KR 101778773 B1 KR101778773 B1 KR 101778773B1
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Images
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2200/00—Function of food ingredients
- A23V2200/30—Foods, ingredients or supplements having a functional effect on health
- A23V2200/332—Promoters of weight control and weight loss
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
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- Polymers & Plastics (AREA)
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- Food Science & Technology (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
Description
The present invention relates to a composition for improving, preventing or treating obesity comprising Ash extract and licorice complex extract.
Obesity is caused by metabolic diseases such as diabetes, arteriosclerosis, cardiovascular disease and hyperlipidemia which are caused by this rather than the severity of obesity itself as serious social problems. Obesity is primarily caused by the accumulation of excess energy in the form of triglycerides and other fatty substances in fat tissue, and is a disease caused by comprehensive metabolic abnormalities due to such energy metabolism imbalance, as well as dietary regulation, appetite regulating hormone metabolism, Such as adipocyte differentiation, lipid synthesis and degradation processes, and heat production.
The research on the development of anti-obesity materials is based on the cytokine signaling 3 suppressor, which induces the resistance of leptin, which is an appetite suppressant, cannabinoid receptor antagonist, which is involved in the regulation of food intake in the hypothalamus receptor 1 antagonist), a neuropeptide Y antagonist that causes an appetite stimulation, and a β3-adrenergic receptor agonist that promotes fat metabolism, metabolic rate-enhancing activity, and growth hormone compounds. Such as PPARδ, which is associated with increased energy expenditure is going to reduce weight.
In the meantime, drugs developed for the treatment of obesity are urgently required to develop a substance having a new action mechanism, which has a serious side effect compared with the effect and has a high anti-obesity effect and a low side effect.
Numerous papers and patent documents are referenced and cited throughout this specification. The disclosures of the cited papers and patent documents are incorporated herein by reference in their entirety to better understand the state of the art to which the present invention pertains and the content of the present invention.
The present inventors have sought to find a natural material having an anti-obesity effect. As a result, the inventors of the present invention have completed the present invention by confirming that the extracts of Ashi agar and licorice complex inhibit the differentiation of adipocytes more effectively than the single extracts.
Accordingly, an object of the present invention is to provide a composition for improving, preventing or treating obesity.
Other objects and advantages of the present invention will become more apparent from the following detailed description of the invention, claims and drawings.
According to one aspect of the present invention, the present invention provides a process for producing Ashwagandha and Glycyrrhiza The present invention provides a pharmaceutical composition for the prevention or treatment of obesity, which comprises an extract of Uralensis as an active ingredient.
The present inventors have sought to find a natural material having an anti-obesity effect. As a result, it has been confirmed that the extracts of Ashi agar and licorice complex inhibit the differentiation of adipocytes more effectively than the single extracts.
Various extracting solvents can be used in the case of obtaining the Ashiana and Licorice extracts used in the composition of the present invention by treating the Ashiana and Licorice with an extractive solvent. Preferably, a polar solvent or a non-polar solvent can be used. Suitable polar solvents are (i) water, (ii) alcohols (preferably methanol, ethanol, propanol, butanol, n-propanol, iso-propanol, n-butanol, 1-pentanol, Or ethylene glycol), (iii) acetic acid, (iv) dimethyl-formamide (DMFO) and (v) dimethyl sulfoxide (DMSO). Suitable nonpolar solvents are acetone, acetonitrile, ethyl acetate, methyl acetate, fluoroalkane, pentane, hexane, 2,2,4-trimethylpentane, decane, cyclohexane, cyclopentane, diisobutylene, 1- But are not limited to, pentane, 1-chlorobutane, 1-chloropentane, o -xylene, diisopropyl ether, 2- chloropropane, toluene, 1- chloropropane, chlorobenzene, benzene, diethyl ether, diethylsulfide, Methane, 1,2-dichloroethane, aniline, diethylamine, ether, carbon tetrachloride, and THF.
More preferably, the extraction solvent used in the present invention is (a) water, (b) anhydrous or hydrated lower alcohol having 1 to 4 carbon atoms (methanol, ethanol, propanol, butanol, etc.) (E) ethyl acetate, (f) chloroform, (g) butyl acetate, (h) 1,3-butylene glycol, (i) hexane and (j) diethyl ether. . Most preferably, the ash agar and licorice extract of the present invention are obtained by treating ethanol with ash ganoderma and licorice.
The extract of the present invention can be extracted by a known natural substance extraction method. For example, the extract may be extracted by a cold extraction, a hot water extraction, an ultrasonic extraction, a reflux cooling extraction, or a heating extraction. According to one embodiment of the present invention, the extract of the present invention can be extracted through hot water extraction or reflux cooling extraction, 1 to 10 times, 1 to 8 times, or 1 to 6 times.
As used herein, the term " extract " means that it is used in the art as a crude extract as described above, but broadly includes fractions obtained by further fractionating the extract. That is, the Ashiana Gochiae extract or licorice extract includes not only those obtained by using the above-mentioned extraction solvent, but also those obtained by further applying a purification process thereto. For example, a fraction obtained by passing the above extract through an ultrafiltration membrane having a constant molecular weight cut-off value, and a separation by various chromatography (manufactured for separation according to size, charge, hydrophobicity or affinity) The fraction obtained by the purification method is also included in the Ashi Kanda extract or licorice extract of the present invention.
The Ashiana extract or licorice extract used in the present invention can be prepared in powder form by an additional process such as vacuum distillation and freeze drying or spray drying.
As used herein, the term " comprising as an active ingredient " means an amount sufficient to attain the efficacy or activity of the following Ashiana and Licorice complex extracts. Since the present invention is a composition extracted from natural plant materials such as Ashiana and licorice, there is no adverse effect on human body even when it is administered in an excessive amount. Therefore, the quantitative upper limit of the amount of Ashiana and licorice extract contained in the composition of the present invention can be selected by a person skilled in the art .
According to one embodiment of the present invention, the combined extract comprises Asa Ganoderma extract and licorice extract at a weight ratio of 1: 1 to 4: 1. According to another embodiment of the present invention, the mixture is constituted at a weight ratio of 1: 1 to 3: 1.
The composition of the present invention can improve, prevent or treat obesity.
The term " obesity " as used herein refers to a state of excess fat tissue in the body. Obesity is defined as the body mass index (BMI), which is the body mass index (BMI) divided by the square of height (m) The fatty acids and glucose that enter the adipocyte from the plasma are esterified and accumulate primarily in the form of triglycerides. Such obesity increases the likelihood of diabetes and hyperlipemia, increases the risk of sexual dysfunction, arthritis, cholelithiasis and cardiovascular disease.
The extracts of Ashi agar and licorice extract of the present invention showed a superior mast cell differentiation inhibitory effect as compared with those of Ashi agar or licorice extract alone. The extracts of Ashi agar and licorice extract showed remarkable synergistic effect on obesity ≪ / RTI >
When the composition of the present invention is manufactured from a pharmaceutical composition, the pharmaceutical composition of the present invention includes a pharmaceutically acceptable carrier. The pharmaceutically acceptable carriers to be contained in the pharmaceutical composition of the present invention are those conventionally used in the present invention and include lactose, dextrose, sucrose, sorbitol, mannitol, starch, acacia rubber, calcium phosphate, alginate, gelatin, But are not limited to, calcium silicate, microcrystalline cellulose, polyvinylpyrrolidone, cellulose, water, syrups, methylcellulose, methylhydroxybenzoate, propylhydroxybenzoate, talc, magnesium stearate and mineral oil. It is not. The pharmaceutical composition of the present invention may further contain a lubricant, a wetting agent, a sweetening agent, a flavoring agent, an emulsifying agent, a suspending agent, a preservative, etc. in addition to the above components. Suitable pharmaceutically acceptable carriers and formulations are described in detail in Remington ' s Pharmaceutical Sciences (19th ed., 1995). The pharmaceutical composition of the present invention can be administered orally or parenterally, and is preferably administered orally.
The appropriate dosage of the pharmaceutical composition of the present invention may vary depending on factors such as the formulation method, administration method, age, body weight, sex, pathological condition, food, administration time, administration route, excretion rate, . Typical dosages of the pharmaceutical compositions of the present invention are in the range of 0.001-1000 mg / kg on an adult basis.
The pharmaceutical composition of the present invention may be formulated into a unit dose form by formulating it using a pharmaceutically acceptable carrier and / or excipient according to a method which can be easily carried out by a person having ordinary skill in the art to which the present invention belongs. Or by intrusion into a multi-dose container. The formulations may be in the form of solutions, suspensions, syrups or emulsions in oils or aqueous media, or in the form of excipients, powders, powders, granules, tablets or capsules, and may additionally contain dispersing or stabilizing agents.
According to another aspect of the present invention, the present invention provides a method for producing Ashwagandha and licorice ( Glycyrrhiza) The present invention also provides a food composition for preventing or ameliorating obesity, which comprises a combination extract of uralensis as an active ingredient.
When the composition for improving obesity containing the active ingredient of the Ash extract and licorice complex according to the present invention is prepared from a food composition, not only the Ash extract and the licorice extract but also the ingredient And includes, for example, proteins, carbohydrates, fats, nutrients, flavoring agents, and flavoring agents. Examples of the above-mentioned carbohydrates are monosaccharides such as glucose, fructose, and the like; Disaccharides such as maltose, sucrose, oligosaccharides and the like; And polysaccharides such as dextrin, cyclodextrin and the like, and sugar alcohols such as xylitol, sorbitol and erythritol. Natural flavorings such as tau martin and stevia extract (e.g., rebaudioside A and glycyrrhizin) and synthetic flavorings (saccharine, aspartame, etc.) can be used as flavorings. For example, when the food composition of the present invention is prepared as a drink, it may further contain citric acid, liquid fructose, sugar, glucose, acetic acid, malic acid, juice, mulberry juice, jujube extract, etc., .
The features and advantages of the present invention are summarized as follows:
(a) The present invention provides a composition for improving, preventing or treating obesity comprising an extract of Ashi agar and licorice as an active ingredient.
(b) The composition of the present invention effectively inhibits differentiation of adipocytes.
(c) The present invention can improve side effects caused by the use of conventional long-term drug treatment of obesity by using natural material.
Fig. 1 shows the results of measurement of inhibitory effect on mast cell differentiation by extracts of Ashi agar, licorice extract and mixtures thereof.
Hereinafter, the present invention will be described in more detail with reference to Examples. It is to be understood by those skilled in the art that these embodiments are only for describing the present invention in more detail and that the scope of the present invention is not limited by these embodiments in accordance with the gist of the present invention .
Example
Experimental Method
extract
Ash agar and licorice were extracted with 70% ethanol.
10% of 70% ethanol was added to each of Ashaganda and licorice powder, and the mixture was extracted with an extraction device equipped with a reflux condenser for 2 hours at 80 ° C, filtered, and concentrated under reduced pressure. The concentrate was lyophilized after freezing and powder was obtained.
Ash extract and licorice blend extract were prepared in proportions of 75:25, 50:50 and 25:75% by weight, respectively, and used in the experiment.
Cell culture
3T3-L1 adipose precursor cells were cultured in DMEM (Dulbecco's Modified Eagle's Medium) medium containing 10% calf serum at 37 ° C and 5% CO 2 at a cell density of 70% And the cells were subcultured periodically.
Cell differentiation
3T3-L1 cells were seeded in 6 well plates at 4 x 10 cells / well, cultured for 3 days, and differentiated into MDI medium. MDI medium was treated with 0.5 mM IBMX, 1 μM dexamethasone, and 1 μ insulin in 10% FBS / DMEM. At this time, the cells were replaced with 1 μ insulin medium after 2 days of differentiation and maintained for up to 8 days in 10% FBS medium after 2 days of culture. Samples were added on
oil Red O dyeing
10% formalin was added and fixed at room temperature for 1 hour. Remove formalin and rinse wells with 60% isopropanol, then flush isopropanol thoroughly from the hood. The oiled red O solution was added to the dried wells and allowed to stand for 10 minutes. The cells were washed with distilled water and the degree of adipocyte differentiation was confirmed by a microscope. Dyeed wells were dissolved in 100% isopropanol and absorbance was measured at 500 nm.
Experiment result
Compared with the control group treated with MDI, the inhibition of adipocyte differentiation by Ash treatment and licorice treatment was suppressed. However, when the two extracts were mixed and treated with the combination, lipid differentiation inhibition effect (Fig. 1).
While the present invention has been particularly shown and described with reference to exemplary embodiments thereof, it is to be understood that the same is by way of illustration and example only and is not to be construed as limiting the scope of the present invention. It is therefore intended that the scope of the invention be defined by the claims appended hereto and their equivalents.
Claims (4)
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023167493A1 (en) * | 2022-03-02 | 2023-09-07 | 주식회사 에이치엘사이언스 | Composition for preventing, alleviating or treating obesity, comprising, as active ingredient, complex (asc complex) of withania somnifera extract and siberian chrysanthemum extract |
| KR20240058622A (en) | 2022-10-26 | 2024-05-03 | 주식회사 에이치엘사이언스 | Composition for enhancing exercise performance comprising a complex of Withania Somnifera extract and Chrysanthemum zawadskii Herbich var. latilobum (Maxim.) Kitamura extract (ASC complex) as an active ingredient |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005102371A2 (en) | 2004-04-27 | 2005-11-03 | Ramaswamy Rajendran | Use of the pregnane glycosides in the treatment/management of obesity, obesity-related and other disorders |
| US8609163B2 (en) | 2010-08-09 | 2013-12-17 | Srm University | Herbal formulation advocated for the prevention and management of coronary heart disease |
-
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005102371A2 (en) | 2004-04-27 | 2005-11-03 | Ramaswamy Rajendran | Use of the pregnane glycosides in the treatment/management of obesity, obesity-related and other disorders |
| US8609163B2 (en) | 2010-08-09 | 2013-12-17 | Srm University | Herbal formulation advocated for the prevention and management of coronary heart disease |
Non-Patent Citations (1)
| Title |
|---|
| 인용발명 : ROHIT KUMAR VERMA 외 1명. International Journal of Pharmacy and Pharmaceutical Sciences. 2014, Vol 6, Suppl 2, pp. 40-47* |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023167493A1 (en) * | 2022-03-02 | 2023-09-07 | 주식회사 에이치엘사이언스 | Composition for preventing, alleviating or treating obesity, comprising, as active ingredient, complex (asc complex) of withania somnifera extract and siberian chrysanthemum extract |
| KR20240058622A (en) | 2022-10-26 | 2024-05-03 | 주식회사 에이치엘사이언스 | Composition for enhancing exercise performance comprising a complex of Withania Somnifera extract and Chrysanthemum zawadskii Herbich var. latilobum (Maxim.) Kitamura extract (ASC complex) as an active ingredient |
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