KR101664877B1 - Cosmetic composition comprising niosome containing nitro fatty acid - Google Patents
Cosmetic composition comprising niosome containing nitro fatty acid Download PDFInfo
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- KR101664877B1 KR101664877B1 KR1020150090908A KR20150090908A KR101664877B1 KR 101664877 B1 KR101664877 B1 KR 101664877B1 KR 1020150090908 A KR1020150090908 A KR 1020150090908A KR 20150090908 A KR20150090908 A KR 20150090908A KR 101664877 B1 KR101664877 B1 KR 101664877B1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/14—Liposomes; Vesicles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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Abstract
The present invention relates to a cosmetic composition comprising a non-ionic surfactant-containing elastomer containing a nitro-fatty acid as an active ingredient, and more particularly to a cosmetic composition comprising a non-ionic surfactant polyglyceryl-6 behenate and an auxiliary surfactant sodium stearoylglutamate The present invention relates to a cosmetic composition for preparing a niozyme and containing a nitro fatty acid in the endoplasmic reticulum space.
Description
The present invention relates to a cosmetic composition comprising a non-ionic surfactant microcapsule containing nitro-fatty acid (Nitro Fatty acid) as an active ingredient, comprising a polyglyceryl-6 behenate as a nonionic surfactant and sodium stearate The present invention relates to a cosmetic composition for producing NSV (Nonionic Surfactant Vesicles) niozyme using sunglutamate and containing nitro fatty acid in the endoplasmic reticulum space.
A delivery system for delivering the active ingredient to the desired site to obtain maximum effect and to prevent the disappearance of the unnecessary ingredient has been continuously studied. Liposomes have been studied extensively as a delivery system. Liposomes are lipid bilayer membranes that are spherical vesicles surrounding the inner aqueduct. Liposomes can enclose both polar and nonpolar components and can increase the duration of action. Despite these advantages, it is difficult to store and handle the phospholipid used, and new materials are being studied due to the disadvantage of high cost. The material being developed through these studies is a liposome-like niozyme that forms a bilayer using non-ionic surfactants. Niobium is a dual membrane transporter composed of a nonionic surfactant, which can contain polar and nonpolar components and is stable and easy to store and handle with surfactants used in manufacturing, and has an advantage in price. These double membranes are not generated spontaneously and require energy such as physical agitation or heat. Thus, liposomes composed of nonionic surfactants are called nioids and also called nonionic surfactant vesicles (NSV).
Depending on the number of bilayers, Niosom has a structure such as Small Unilamellar Vesicle (SUV), Large Unilamellar Vesicle (LUV), Giant Unilamellar Vesicle (GUV) and Multilamellar Vesicle (MLV) Is known. Manufacture methods include the hand-shaking method (thin film method), ether injection method, sonication, and reversed phase evaporation.
The stable nonionic surfactant used in the NSV may be a polyoxyethylene alkyl ether, a polyoxyethylene alkyl ester, a saccharose diester or the like, Various non-ionic surfactants have been used for the development of active agents. The niosome and liposomes are similar in structure but different, and the stabilization of these vesicles is governed by the cholesterol component that maintains the membrance.
One of the nonionic surfactants used in the manufacture of niobium (NSV) is polyglyceryl-6 behenate raw material, which is a 100% natural plant-derived ingredient and is often used as an emulsifier in an underwater type emulsion. Glycerin derived from vegetable oil is converted into polyglycerol-6 by dehydration condensation and esterified with behenic acid which is a fatty acid derived from vegetable oil. Various polyglycerin surfactants are produced depending on the degree of polymerization of polyglycerol, the type of fatty acid and the degree of esterification.
HLB products having a wide range of hydrophilicity to lipophilicity can be obtained according to the average degree of polymerization of polyglycerol used as a hydrophilic group, the type of fatty acid used as a lipophilic group, and the number of fatty acids to be bonded (degree of esterification). Sodium stearoyl glutamate is an excellent emulsifier for anionic type water-in-oil emulsions. It can achieve the desired effect even when used in a small amount and can be mixed with water or oil phase, and can be used at high temperature or low temperature.
Nitro fatty acids are compounds in which a nitro group is substituted for a carbon chain of a fatty acid and are known to help a cardiovascular disease such as hypertension, stroke, myocardial infarction and the like as a compound which is formed by bonding of a nitrogen compound to an unsaturated fatty acid easily (The Journal Proceedings of National Academy of Science, Arterioscler Thromb Vasc Biol . 2010; 30: 938-945).
In addition, nitrofatty acid has been reported to have excellent anti-inflammatory effects through previous studies (The Journal of Biological Chemistry vol. 284, No. 3, 14611473, January 16, 2009).
The present invention provides a cosmetic composition which is improved in stability of contents when the nitro fatty acid is applied to a cosmetic composition and at the same time promotes skin percutaneous absorption by controlling the particle size and thereby imparts radiance and elasticity to the skin, The purpose.
The present invention relates to a cosmetic composition comprising a non-ionic surfactant-containing elastomer containing a nitro-fatty acid as an active ingredient, and more particularly to a cosmetic composition comprising a non-ionic surfactant polyglyceryl-6 behenate and an auxiliary surfactant sodium stearoylglutamate The present invention relates to a cosmetic composition for preparing a niozyme and containing a nitro fatty acid in the endoplasmic reticulum space.
Preferably, the niozyme may comprise from 5.0 to 10.0% by weight of polyglyceryl-6 behenate and from 0.1 to 1.0% by weight of sodium stearoylglutamate based on the total weight of the niozyme.
Preferably, the niozyme comprises 5.0 to 30.0% by weight of a nitro fatty acid, 5.0 to 10.0% by weight of polyglyceryl-6 behenate, 0.1 to 1.0% by weight of sodium stearoylglutamate, 1.0 to 5.0 wt% of PEG-5 rapeseed oil sterol, 1.0 to 5.0 wt% of cholesterol, 10.0 to 20.0 wt% of heavy chain triglyceride, 10.0 to 20.0 wt% of jojoba seed oil % And residual water.
Preferably the nitro fatty acid is selected from the group consisting of 9-nitro-9-cis-octadecenoic acid, 10-nitro-9-cis-octadecenoic acid, 9- Octadeca-9,11-dienic acid, and the like.
Preferably, the niozyme may have a particle size of 110-150 nm.
Preferably, the cosmetic composition may be for improving skin elasticity.
Preferably, the cosmetic composition is in the form of a solution, suspension, emulsion, paste, gel, cream, lotion, powder, soap, surfactant-containing cleansing, oil, powder foundation, And may have a formulation to be selected.
The composition prepared according to the method of the present invention has an advantage of improving solubility in water, quick penetration of drug and stability of formulation, and the cosmetic composition of the present invention containing such niobose (NSV) Wrinkle and gloss improvement effect.
BRIEF DESCRIPTION OF THE DRAWINGS Figure 1 is a particle size distribution chart of a niobose (NSV) containing nitro fatty acid prepared according to the present invention.
Figure 2 is a frozen electron micrograph of a niobose (NSV) containing nitro fatty acid prepared according to the present invention.
The present invention relates to a cosmetic composition comprising a niozyme containing a nitro fatty acid.
The term "nitro fatty acid" used in the present invention is generically referred to as a compound in which a nitro group is bonded to a carbon chain of a fatty acid. Specifically, 9-Nitro-9-cis-octadecenoic acid, 10-Nitro-9-cis-octadecenoic acid, 9-Nitro-octadeca-9,11-dienoic acid, 12-nitro-octadeca-9, 11-dienoic acid), and the like. Preferably 9-nitro-9-cis-octadecenoic acid or 10-nitro-9-cis-octadecenoic acid. The nitro fatty acid may be included in an amount of 5.0 to 30.0% by weight based on the total weight of the niozyme. When the content of the nitro fatty acid is less than 5.0% by weight, the effect is insignificant. When the content is more than 30.0% by weight, skin irritation may be caused.
In one embodiment according to the present invention, the niozyme may comprise from 5.0 to 10.0% by weight of polyglyceryl-6 behenate and from 0.1 to 1.0% by weight of sodium stearoyl glutamate based on the total weight of the niozyme. In still another embodiment of the present invention, the niozyme comprises 5.0 to 30.0% by weight of nitro fatty acid, 5.0 to 10.0% by weight of polyglyceryl-6 behenate, 0.1 to 10% by weight of sodium stearoyl glutamate, 1.0 to 5.0 wt.% Of PEG-5 rapeseed oil sterol, 1.0 to 5.0 wt.% Of cholesterol, 10.0 to 20.0 wt.% Of heavy chain triglyceride, 1.0 to 5.0 wt.% Of glycerin, 5.0 to 10.0 wt.% Of glycerin, 1.0 to 5.0 wt. 10.0 to 20.0% by weight of jojoba seed oil and the balance water.
Polyglyceryl-6 behenate raw material, one of the non-ionic surfactants used in the manufacture of niobium, is an effective O / W emulsifier of PEG-free as a 100% natural plant-derived ingredient. Glycerin derived from vegetable oil is converted into polyglycerol-6 by dehydration condensation and esterified with behenic acid which is a fatty acid derived from vegetable oil. Various polyglycerin surfactants are produced depending on the degree of polymerization of polyglycerol, the type of fatty acid and the degree of esterification. The weight of the polyglyceryl-6 behenate according to the present invention is preferably 5.0 to 10.0% by weight based on the total weight of the niozyme. There is a problem that formation of niozyme is difficult or it is difficult to maintain the formulation of niozyme within the above range.
In addition, sodium stearoylglutamate in the niozyme composition is used as a secondary emulsifier and may be included in an amount of 0.1 to 1.0 wt% based on the total weight of the niozyme. Glycerin may be included in 5.0 to 10.0% by weight and used as a solvent with water. 1.0 to 5.0% by weight of Ceteth-3, 1.0 to 5.0% by weight of PEG-5 rapeseed oil sterols, and 1.0 to 5.0% by weight of cholesterol in order to facilitate formation of bezicel, 10.0-20.0% by weight of triglycerides and 10.0-20.0% by weight of jojoba seed oil.
The nanosomes according to the present invention may have a particle size of 110-150 nm. Preferably, it may have a particle size of 120 to 140 nm. Since the intercellular lipids are 100 to 200 nm, the nioxia having particle sizes different from those of the present invention are effective for transdermal absorption.
The niozyme according to the present invention can be prepared as follows. Polyglyceryl-6 behenate, Ceteth-3, PEG-5 rapeseed oil sterol, cholesterol, and sodium stearoylglutamate are dissolved by heating at 80 to 100 ° C and then mixed with the heated solvent. The mixture is wetted at 80 to 100 占 폚 for 1 to 2 hours, and then cooled to 30 to 40 占 폚. Then, the nitric acid is added and oil is added to emulsify. Thereafter, the mixture is passed through a high-pressure homogenizer for about 1,000 times continuously five to ten times, followed by cooling and defoaming to obtain a niozyme according to the present invention.
The cosmetic composition according to the present invention can be used for improving skin elasticity.
The cosmetic composition according to the present invention may be selected from the group consisting of solutions, suspensions, emulsions, pastes, gels, creams, lotions, powders, soaps, surfactant-containing cleansing, oils, powder foundations, emulsion foundations, wax foundations and sprays ≪ / RTI >
Hereinafter, the present invention will be described in detail with reference to examples. However, the examples are given for the purpose of helping understanding of the present invention, and thus the scope of the present invention is not limited thereto.
Example One : Nitro fatty acids Containing Vezic Produce( NSV )
Table 1 below shows the composition of constituents for preparing nioxides containing nitroso fatty acids according to the present invention.
Polyglyceryl-6 behenate, Ceteth-3, PEG-5 rapeseed oil, cholesterol, and sodium stearoylglutamate were dissolved by heating at 90 ° C, glycerin and purified water were heated to a temperature of 80 ° C or higher, , Wetted at 90 캜 for 1 hour, and cooled to 40 캜. Nitro fatty acid was added, oil was added to emulsify the oil, and the mixture was passed through a high-pressure homogenizer five times in succession for 1,000 times, followed by cooling and defoaming to obtain a niozyme.
Comparative Example One: Nitro fatty acids Used general emulsion
A general emulsion was prepared with the composition shown in Table 2 below.
The above components were introduced into a vessel and dissolved at a temperature of 80 DEG C, followed by mixing for 5 minutes using a homomixer, followed by cooling and defoaming to obtain a general emulsion (Comparative Example 1).
Experimental Example One: Nio Particle distribution ( Photal , ELS-Z measurement)
The particle distribution of the niozyme prepared in Example 1 was measured using Photal and ELS-Z, and it was found that the average particle size was 128 nm.
Fig. 1 is a particle distribution chart of a niozyme containing a nitro fatty acid prepared according to the present invention.
Experimental Example 2: Nio Particle photograph (frozen electron microscope measurement)
The nanosome prepared in Example 1 was measured using a freezing electron microscope (Photo Graphing Freeze-Fracture Scanning Electron Microscopy) because the particle size was too small to measure with a general optical microscope.
FIG. 2 shows a frozen electron micrograph of a niozyme containing a nitro fatty acid prepared according to the present invention, and it can be confirmed that niozyme is well formed.
Experimental Example 3: Nitro fatty acid Nio Percutaneous Experiment of absorbing acceleration
8 weeks of female guinea pig strain (strain IAF / HA-hrBR) was used. The skin of the abdomen of guinea pig was cut and tested in a Franz-type diffusion cell (Lab fine instruments, Korea). The diffusion cells were mixed and dispersed at 32 ° C and 600 rpm in 50 mM phosphate buffer (pH 7.4, 0.1 M NaCl) in a Receptor container (5 ml) of a Franz-type diffusion cell. 50 mu l of the general emulsion of Example 1 and Comparative Example 1 was placed in a donor vessel. Absorbed and diffused according to a predetermined time, and the skin on which absorption diffusion occurred was made to be 0.64 cm < 2 & gt ;. After the absorption and diffusion of the active ingredient is completed, the emulsions remaining on the skin that can not be absorbed by the dried kimwipes or 10 ml of ethanol are washed, and the skin in which the active ingredient is absorbed and diffused is worn by using a tip- Nitrogen fatty acid absorbed inside was extracted with 4 ml of dichloromethane. After that, the extract was filtered with a 0.45 μm nylon membrane filtration membrane, and the content was measured by HPLC method under the following conditions, and the results are shown in Table 3.
- Column: C18 (4.6 x 200 mm, 5 m)
- mobile phase: methanol: hexane = 2: 1
- flow rate: 0.8 ml / min
- Detector: UV 275 nm
From the results of the experiment, it was found that the niozyme containing the nitro fatty acid prepared according to the present invention had a higher effect on the skin than the normal emulsion. It was found that the nanosome was very well formed as a result of the particle photograph.
Experimental Example 4: Nitro fatty acid Nio Skin roll Improvement effect
The skin elasticity improvement effect of the nioxia (Example 1) and the general emulsion (Comparative Example 1) containing the nitro fatty acid was evaluated as follows.
The emulsion of Example 1 was applied to the right side of the face and the emulsion of Comparative Example 1 was applied to the left side of the face for 15 consecutive months for 15 consecutive months.
The skin elasticity was measured by using a skin elasticity meter (SEM 575, C + K Electronic Co., Germany) before use and after 1 month of use. The results are shown in Table 4 below as the ΔR8 value of Cutometer SEM 575, where the value of R8 indicates the viscoelasticity of the skin.
As shown in the following Table 4, it can be seen that when the niacose containing nitro fatty acid is applied, the skin elasticity improving effect is excellent.
Claims (7)
Wherein the niozyme comprises 5.0 to 30.0 wt% of nitro fatty acid, 5.0 to 10.0 wt% of polyglyceryl-6 behenate, and 0.1 to 1.0 wt% of sodium stearoyl glutamate, based on the total weight of the niozyme.
Wherein the niozyme comprises 5.0 to 30.0% by weight of nitro fatty acid, 5.0 to 10.0% by weight of polyglyceryl-6 behenate, 0.1 to 1.0% by weight of sodium stearoyl glutamate, 5.0 to 10.0% by weight of glycerin, 1.0 to 5.0 wt% of Ceteth-3, 1.0 to 5.0 wt% of PEG-5 rapeseed oil sterols, 1.0 to 5.0 wt% of cholesterol, 10.0 to 20.0 wt% of heavy chain triglycerides, 10.0 to 20.0 wt% of jojoba seed oil, Wherein the composition comprises water.
The nitro fatty acids are selected from the group consisting of 9-nitro-9-cis-octadecenoic acid, 10-nitro-9-cis-octadecenoic acid, 9- , And 11-dienoic acid.
Wherein the nanosome has a particle size of 110-150 nm.
The cosmetic composition may be in the form of a solution, suspension, emulsion, paste, gel, cream, lotion, powder, soap, surfactant-containing cleansing, oil, powder foundation, emulsion foundation, wax foundation and spray .
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20190053438A (en) * | 2017-11-10 | 2019-05-20 | 주식회사 코리아나화장품 | Cosmetic composition having shining pearl surface containing magnolia sieboldii extract |
| KR20220078106A (en) * | 2020-12-03 | 2022-06-10 | 주식회사 코스메카코리아 | Niosomes omega ceramides and cosmetic compositions comprising them as active ingredients |
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| WO2010054495A2 (en) * | 2008-11-14 | 2010-05-20 | Profimed S.R.O. | Non-aqueous colloidal formulation |
| WO2013003689A2 (en) * | 2011-06-30 | 2013-01-03 | Nitromega Corp. | Compositions containing nitro fatty acids |
| US20130028950A1 (en) * | 2010-03-31 | 2013-01-31 | Shiseido Company, Ltd. | Vesicle-Containing Composition |
| KR20130030552A (en) * | 2011-09-19 | 2013-03-27 | 코스맥스 주식회사 | Cosmetic composition containing nonionic surfactant vesicles including red ginseng extract |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010054495A2 (en) * | 2008-11-14 | 2010-05-20 | Profimed S.R.O. | Non-aqueous colloidal formulation |
| US20130028950A1 (en) * | 2010-03-31 | 2013-01-31 | Shiseido Company, Ltd. | Vesicle-Containing Composition |
| WO2013003689A2 (en) * | 2011-06-30 | 2013-01-03 | Nitromega Corp. | Compositions containing nitro fatty acids |
| KR20130030552A (en) * | 2011-09-19 | 2013-03-27 | 코스맥스 주식회사 | Cosmetic composition containing nonionic surfactant vesicles including red ginseng extract |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20190053438A (en) * | 2017-11-10 | 2019-05-20 | 주식회사 코리아나화장품 | Cosmetic composition having shining pearl surface containing magnolia sieboldii extract |
| KR101993376B1 (en) * | 2017-11-10 | 2019-06-26 | 주식회사 코리아나화장품 | Cosmetic composition having shining pearl surface containing magnolia sieboldii extract |
| KR20220078106A (en) * | 2020-12-03 | 2022-06-10 | 주식회사 코스메카코리아 | Niosomes omega ceramides and cosmetic compositions comprising them as active ingredients |
| KR102572588B1 (en) * | 2020-12-03 | 2023-09-01 | 주식회사 코스메카코리아 | Niosomes omega ceramides and cosmetic compositions comprising them as active ingredients |
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